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CCNA1 Gene

protein-coding   GIFtS: 65
GCID: GC13P037005

Cyclin A1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin A11 2
CT1462
cyclin-A12

External Ids:    HGNC: 15771   Entrez Gene: 89002   Ensembl: ENSG000001331017   OMIM: 6040365   UniProtKB: P783963   

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNA1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and
brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the
germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase
activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This
cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor
E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA1 Gene:
CCNA1 (cyclin A1) is a protein-coding gene. Diseases associated with CCNA1 include polyploidy, and male germ cell tumor. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
cell cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNA1 gene promoter:
         MyoD   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNA1 promoter sequence
   Search Chromatin IP Primers for CCNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037005:  view genomic region     (about GC identifiers)

Start:
37,005,967 bp from pter      End:
37,017,019 bp from pter
Size:
11,053 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)
Recommended Name: Cyclin-A1  
Size: 465 amino acids; 52358 Da
Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme
complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro).
The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with
CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9
Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M
phases
Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91
Alternative splicing: 3 isoforms:  P78396-1   P78396-2   P78396-3   

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Explore proteomics data for CCNA1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its
    degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase1
  • Modification sites at neXtProt

  • See CCNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001104515.1  NP_001104516.1  NP_001104517.1  NP_003905.1  

    ENSEMBL proteins: 
     ENSP00000255465   ENSP00000396479   ENSP00000400666   ENSP00000409873  
    Reactome Protein details: P78396

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR015453 Cyclin_A
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P78396

    ProtoNet protein and cluster: P78396

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    CCNA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNA1_HUMAN, P78396
    Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
    primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
    cell cycle in some somatic cells

         Genatlas biochemistry entry for CCNA1:
    cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell
    lines,regulator of cell-cycle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0019901protein kinase binding IEA--
         
    CCNA1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccna1):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     reproductive system 

    CCNA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccna1tm1Djw for CCNA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNA1

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNA1

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    miRTarBase miRNAs that target CCNA1:
    hsa-mir-335-5p (MIRT018229), hsa-mir-124-3p (MIRT022823), hsa-let-7b-5p (MIRT032444)

    Block miRNA regulation of human, mouse, rat CCNA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCNA1:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidCCNA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNA1

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    GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
    Sino Biological Human cDNA Clone for CCNA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNA1_HUMAN, P78396: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS9041194
    GO:0015630microtubule cytoskeleton IDA--

    CCNA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNA1 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    G1 to S cell cycle control0.35
    2Cell cycle Regulation of G1 S transition part 2
    Cell cycle Cell cycle generic schema 0.38
    Cell cycle ESR1 regulation of G1 S transition0.33
    Cell cycle Regulation of G1 S transition part 2 0.38
    G2 Phase0.00
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    DNA Replication0.92
    Regulation of mitotic cell cycle0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cyclin E associated events during G1/S transition0.86
    Switching of origins to a post-replicative state0.93
    Removal of licensing factors from origins0.86
    5Cellular Senescence
    Cellular Senescence0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNA1 (see all 9)
        Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling
    Breast Cancer Regulation by Stathmin1
    G1-S Phase Transition
    Estrogen-mediated S-Phase Entry

    Selected GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cell cycle Chromosome condensation in prometaphase
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of APC in cell cycle regulation

    5 BioSystems Pathways for CCNA1
        Cell cycle
    G1 to S cell cycle control
    AMPK signaling
    Gastric cancer network 1
    C-MYB transcription factor network


    Selected Reactome Pathways for CCNA1 (see all 12) (see first 5)
        SCF(Skp2)-mediated degradation of p27/p21
    G0 and Early G1
    Orc1 removal from chromatin
    E2F mediated regulation of DNA replication
    G1/S-Specific Transcription
    Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
    Senescence-Associated Secretory Phenotype (SASP)
    Regulation of APC/C activators between G1/S and early anaphase
    Cyclin A:Cdk2-associated events at S phase entry
    Cyclin A/B1 associated events during G2/M transition


    Selected Kegg Pathways  (Kegg details for CCNA1) (see all 8):
        Cell cycle
    Progesterone-mediated oocyte maturation
    Hepatitis B
    Epstein-Barr virus infection
    Pathways in cancer


    CCNA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNA1 (P783961, 2, 3 ENSP000002554654) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM4P339912, 3, ENSP000002621054MINT-50427 I2D: score=4 STRING: ENSP00000262105
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    CCNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNA1

    2 Novoseek inferred chemical compound relationships for CCNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 22.1 20 16517207 (6), 11090075 (4), 15489899 (2)
    vegf 16.9 14 16007189 (7), 18612129 (5), 18534064 (1)



    CCNA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts): 
    NM_001111045.1  NM_001111046.1  NM_001111047.1  NM_003914.3  

    Unigene Cluster for CCNA1:

    Cyclin A1
    Hs.417050  [show with all ESTs]
    Unigene Representative Sequence: NM_003914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463403 ENST00000255465 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)
    ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat CCNA1

    Additional mRNA sequence: 

    AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1 
    U97680.1 

    3 DOTS entries:

    DT.113428  DT.75122607  DT.95165865 

    Selected AceView cDNA sequences (see all 68):

    F13244 BC035479 CR616879 BE336946 BC036346 AI168235 BM552862 F10846 
    AA420962 AA421060 F10700 AA777001 CN480841 BX281383 BI825398 BE242314 
    BI462532 AW237229 CD171793 BG720085 BI459787 BE242234 BI770824 BP369757 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                    -     -                                                                     
    SP4:                    -     -                                                                     
    SP5:        -     -     -     -                                                                     


    ECgene alternative splicing isoforms for CCNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCACCTG
    CCNA1 Expression
    About this image


    CCNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    CCNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.417050

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell
    lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNA1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccna11 , 5 cyclin A11, 5 83.37(n)1
    84.32(a)1
      3 (26.52 cM)5
    124271  NM_007628.31  NP_031654.21 
     550454695 
    chicken
    (Gallus gallus)
    Aves CCNA11 cyclin A1 69.89(n)
    68.73(a)
      418901  XM_417097.4  XP_417097.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNA16
    cyclin A1
    63(a)
    1 ↔ 1
    3(181635608-181652755)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978852 Xenopus mRNA for cyclin A1 73.47(n)    X53745.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccna11 cyclin A1 61.03(n)
    61.97(a)
      404206  NM_212818.1  NP_997983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycA3 mitosis cyclin-dependent protein
    kinase, regulator
    41(a)   68E1   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCA3;21 CYCA3;2 53.16(n)
    45.83(a)
      841124  NM_103614.4  NP_564499.3 
    rice
    (Oryza sativa)
    Liliopsida AK063476.12   -- 77.16(n)    AK063476.1 


    ENSEMBL Gene Tree for CCNA1 (if available)
    TreeFam Gene Tree for CCNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCNA1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCND22  CCNA22  
    1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries:     CCNA1_HUMAN (see all proteins):
    CCNA2

    CCNA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CCNA1 (see all 325)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131870871,2
    C,F--37003968(+) GGTCTG/CGATCT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs714381001,2
    C,F--37003990(+) GATTCG/ACCTGC 2 -- us2k16Minor allele frequency- A:0.21NA CSA WA EA 364
    rs756497191,2
    F--37004127(+) ACACAT/GAGATA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1156062741,2
    C,F--37004131(+) ATAGAT/CATCAG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1129835041,2
    C,F--37004279(+) AAAAAG/CATGTT 2 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1479809801,2
    --37004595(+) GACAGG/TTTCCA 4 -- us2k10--------
    rs1416052531,2
    --37004684(+) AATCAA/GATGAA 4 -- us2k10--------
    rs38148051,2
    C--37004716(-) GCTCAC/GGAGAC 4 -- us2k110Minor allele frequency- G:0.14NA EA WA 726
    rs38148041,2
    C,F--37004787(-) ACTCCG/TTCTGG 4 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1505122601,2
    --37004901(+) AAATGC/TTCCTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899993CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604036    OMIM disorders: --

    Selected diseases for CCNA1 (see all 42):    
    About MalaCards
    polyploidy    male germ cell tumor    testicular cancer    cervical intraepithelial neoplasia
    acute promyelocytic leukemia    wilms tumor    laryngeal squamous cell carcinoma    male infertility
    osteosarcoma    retinoblastoma    germ cell tumors    myeloid leukemia
    lymphoblastic leukemia    chronic myeloid leukemia    acute myeloid leukemia    azoospermia
    oral cancer    infertility    laryngitis    cervicitis

    1 disease from the University of Copenhagen DISEASES database for CCNA1:
    Acute myeloid leukemia

    CCNA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCNA1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 53 5 11381140 (2), 11090075 (1), 10590070 (1)
    leukemia 34.3 17 19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
    leukemia promyelocytic acute 27.2 3 11090075 (3)
    testicular cancer 26.5 1 14510182 (1)
    retinoblastoma 25 3 17455244 (3)
    tumors 24.6 19 18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
    wilms tumor 23.4 2 15526363 (1)
    osteosarcoma 22.7 1 10757815 (1)
    cancer 14.1 5 11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
    lymphoblastic leukemia acute 8.84 1 16102826 (1)

    Genetic Association Database (GAD): CCNA1
    Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

    Export disorders for CCNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNA1 gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with CCNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)1, 2, 3, 9 Yang R.... Koeffler H.P. (Cancer Res. 1997)
    2. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)1, 2, 9 Yang R.... Koeffler H.P. (Mol. Cell. Biol. 1999)
    3. Mutations of the cyclin A1 gene are not a common cause of male infertility. (PubMed id 19886767)1, 4, 9 Zhoucun A....Yang Y. (Syst Biol Reprod Med 2009)
    4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    5. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)1, 2 Diederichs S.... Mueller-Tidow C. (J. Biol. Chem. 2004)
    6. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)1, 9 Wegiel B....Persson J.L. (J. Natl. Cancer Inst. 2008)
    7. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)1, 9 Wegiel B....Persson J.L. (Oncogene 2005)
    8. DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)1, 9 Ji P....MA1ller-Tidow C. (Int. J. Cancer 2007)
    9. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)1, 9 Liao C....Wolgemuth D.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)1, 9 Yang R....Koeffler H.P. (Blood 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8900 HGNC: 1577 AceView: CCNA1 Ensembl:ENSG00000133101 euGenes: HUgn8900
    ECgene: CCNA1 Kegg: 8900 H-InvDB: CCNA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCNA1 gene:
    Search GeneIP for patents involving CCNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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