CCNA1 Gene

Aliases
for CCNA1 gene

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817

Summaries
for CCNA1 gene

Genomic Views
for CCNA1 gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_024524.14  

SwitchGear Promoter luciferase reporter plasmid: CCNA1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA1

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037005:  view genomic region     (about GC identifiers)

Proteins
for CCNA1 gene

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CCNA1 OriGene Protein Over-expression Lysate: CCNA1 OriGene Custom Protein Services for CCNA1
	GenScript Custom Purified and Recombinant Proteins Services for CCNA1
	Novus Biologicals CCNA1 Protein Novus Biologicals CCNA1 Lysate
	Sino Biological Recombinant Protein for CCNA1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCNA1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
	R&D Systems Antibodies for CCNA1 (Cyclin A1)
	OriGene Antibodies: CCNA1 OriGene Custom Antibody Services for CCNA1
	GenScript Custom Superior Antibodies Services for CCNA1
	Novus Biologicals CCNA1 Antibodies
	Search for Antibodies for CCNA1 at Abcam
	Uscn Antibodies for CCNA1
	ThermoFisher Antibody for CCNA1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNA1

Protein Domains /
Families
for CCNA1 gene

ProtoNet protein and cluster: P78396

Function
for CCNA1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 4): CCNA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
		hsa-miR-656
		SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNA1 (see all 7) OriGene shRNA RFP: CCNA1 OriGene siRNA: CCNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CCNA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA1 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
		Sino Biological Human cDNA Clone for CCNA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNA1
		Search LifeMap BioReagents cell lines for CCNA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Ccna1)

Pathways & Interactions
for CCNA1 gene

	Super-pathway	contained gene-specific pathways
1	Ubiquitinated Orc1 is degraded by the proteasome	8/16 pathways (see all 16) Degradation of ubiquitinated p27/p21 by the 26S proteasome 0.75 Cyclin E associated events during G1/S transition 0.67 SCF(Skp2)-mediated degradation of p27/p21 0.75 Cyclin A:Cdk2-associated events at S phase entry 0.66 Switching of origins to a post-replicative state 0.70 Regulation of APC/C activators between G1/S and early anaphase 0.62 Orc1 removal from chromatin 0.70 Regulation of mitotic cell cycle 0.58
2	Cell cycle_Cell cycle (generic schema)	Cell cycle_Cell cycle (generic schema) 1.00 Cell cycle Regulation of G1/S transition (part 2) 0.38 Cell cycle Cell cycle (generic schema) 1.00 G0 and Early G1 0.31 Cell cycle_Regulation of G1/S transition (part 2) 0.38
3	G1/S-Specific Transcription	G1/S-Specific Transcription 1.00 E2F mediated regulation of DNA replication 0.45 Activation of E2F target genes at G1/S 1.00
4	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 1.00 G2 Phase 0.43 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes 0.60
5	Cell cycle	Cell cycle 1.00 G1 to S cell cycle control 0.38 Cell cycle 0.57

5/10 EMD Millipore Pathways for CCNA1

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA1

	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling
	Breast Cancer Regulation by Stathmin1
	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry

5/9 GeneGo (Thomson Reuters) Pathways for CCNA1

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell cycle Chromosome condensation in prometaphase
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of APC in cell cycle regulation

4 BioSystems Pathways for CCNA1

	Cell cycle
	G1 to S cell cycle control
	AMPK signaling
	C-MYB transcription factor network

5/30        Reactome Pathways for CCNA1

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	DNA Replication
	G0 and Early G1
	Removal of licensing factors from origins

4         Kegg Pathways  (Kegg details for CCNA1)

	Cell cycle
	Progesterone-mediated oocyte maturation
	Pathways in cancer
	Acute myeloid leukemia

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for CCNA1 gene

Transcripts
for CCNA1 gene

Expression
for CCNA1 gene

CCNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCACCTG

Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)			Endothelium
	Matrigel embedded cells (Derivation of cardio...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

Orthologs
for CCNA1 gene

Paralogs
for CCNA1 gene

Paralogs for CCNA1 gene

CCND3²  CCNO²  CCNE1²  CCNB2²  CCNE2²  CCNB3²  CCNB1²  CCND1²  

CCND2²  CCNA2²  

1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries:     CCNA1_HUMAN (see all proteins):

CCNA2

CCNA1 for paralogs           About GeneDecksing

Genomic Variants
for CCNA1 gene

10/264 NCBI SNPs in CCNA1 are shown (see all 264)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1131870871,2		--	37003968(+)	GGTCTG/CGATCT	2	--	us2k1		1		CSA	2
rs714381001,2	C,F,	--	37003990(+)	GATTCG/ACCTGC	2	--	us2k1		6		NA CSA WA EA	364
rs756497191,2	F,	--	37004127(+)	ACACAT/GAGATA	2	--	us2k1		1		WA	118
rs1156062741,2	C,F,	--	37004131(+)	ATAGAT/CATCAG	2	--	us2k1		1		WA	118
rs1129835041,2		--	37004279(+)	AAAAAG/CATGTT	2	--	us2k1		2		CSA WA	120
rs1479809801,2		--	37004595(+)	GACAGG/TTTCCA	4	--	us2k1		0	--	--	--	--
rs1416052531,2		--	37004684(+)	AATCAA/GATGAA	4	--	us2k1		0	--	--	--	--
rs38148051,2	C,	--	37004716(-)	GCTCAC/GGAGAC	4	--	us2k1		10		NA EA WA	726
rs38148041,2	C,F,	--	37004787(-)	ACTCCG/TTCTGG	4	--	us2k1		1		EA	120
rs1505122601,2		--	37004901(+)	AAATGC/TTCCTT	4	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CCNA1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNA1

DNA2.0 Custom Variant and Variant Library Synthesis for CCNA1

Disorders / Diseases
for CCNA1 gene

20/39 diseases for CCNA1

10/13 Novoseek disease relationships for CCNA1 gene (see all 13)    About this table

Publications
for CCNA1 gene

PubMed articles for CCNA1 gene, integrated from 9 sources (see all 162) (see top 10): (articles sorted by number of sources associating them with CCNA1)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)^{1, 2, 3, 9} Yang R.... Koeffler H.P. (1997)
2. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)^{1, 2, 9} Yang R.... Koeffler H.P. (1999)
3. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)^{1, 2} Diederichs S.... Mueller-Tidow C. (2004)
4. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)^{1, 9} Wegiel B....Persson J.L. (2008)
5. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)^{1, 9} Wegiel B....Persson J.L. (2005)
6. DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)^{1, 9} Ji P....Muller-Tidow C. (2007)
7. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)^{1, 9} Liao C....Wolgemuth D.J. (2001)
8. Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)^{1, 9} Yang R....Koeffler H.P. (1999)
9. NGF inhibits human leukemia proliferation by downregu lating cyclin A1 expression through promoting acinus/CtBP2 association. (PubMed id 19668232)^{1, 9} Chan C.B....Ye K. (2009)
10. Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells. (PubMed id 18787932)^{1, 9} Ekberg J. and Persson J.L. (2009)
11. Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. (PubMed id 16799873)^{1, 9} Rivera A....Maxwell S.A. (2006)
12. Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology. (PubMed id 11172814)^{1, 9} Muller-Tidow C....Serve H. (2001)
13. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. (PubMed id 11264176)^{1, 9} Muller-Tidow C....Koeffler H.P. (2001)
14. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. (PubMed id 10196209)^{1, 9} Muller C....Koeffler H.P. (1999)
15. A distinct cyclin A is expressed in germ cells in the mouse. (PubMed id 8565853)^{1, 9} Sweeney C....Carrington M. (1996)
16. Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2. (PubMed id 19056339)^{1, 9} Joshi A.R....Wolgemuth D.J. (2009)
17. Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice. (PubMed id 12579332)^{1, 9} Muller-Tidow C....Koeffler H.P. (2003)
18. [Expression of cyclin A1 mRNA in patients with myelodysplastic syndrome and its clinical significance.] (PubMed id 19379570)^{1, 9} Jia J.S. and Xu S.R. (2009)
19. The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells. (PubMed id 17530187)^{1, 9} Yang D....Zhou Z. (2007)
20. Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. (PubMed id 16449996)^{1, 9} Shaw R.J....Risk J.M. (2006)
21. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. (PubMed id 15342377)^{1, 9} Tokumaru Y....Sidransky D. (2004)
22. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. (PubMed id 10068472)^{1, 9} Ravnik S.E. and Wolgemuth D.J. (1999)
23. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PubMed id 20457893)^{1, 9} Hsia D.A....Izumiya Y. (2010)
24. Mutations of the cyclin A1 gene are not a common caus e of male infertility. (PubMed id 19886767)^{1, 9} Zhoucun A....Yang Y. (2009)
25. Cyclin A1 shows age-related expression in benign tonsi ls, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate i n HNSCC independently of HPV16. (PubMed id 22712549)¹ Weiss D....Rudack C. (2012)
26. Cyclin-A1 represents a new immunogenic targetable anti gen expressed in acute myeloid leukemia stem cells with characteristics of a can cer-testis antigen. (PubMed id 22529286)¹ Ochsenreither S....Greenberg P.D. (2012)
27. The ubiquitin-specific protease USP2a enhances tumor p rogression by targeting cyclin A1 in bladder cancer. (PubMed id 22370483)¹ Kim J....Freeman M.R. (2012)
28. Human papillomavirus's physical state and cyclin A1 p romoter methylation in cervical cancer. (PubMed id 21412159)¹ Yanatatsaneejit P....Kitkumthorn N. (2011)
29. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
30. Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independe ntly of p53 mutation. (PubMed id 21563216)¹ Weiss D....Rudack C. (2011)
31. Oxidized low density lipoprotein induces cyclin A synt hesis. Involvement of ERK, JNK and NFkappaB. (PubMed id 21764057)¹ Maziere C....Maziere J.C. (2011)
32. MicroRNA-372 is down-regulated and targets cyclin-dep endent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contri bute to tumorigenesis. (PubMed id 21646351)¹ Tian R.Q....Tang H. (2011)
33. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)² Huang X.... Dixit V.M. (2011)
34. Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. (PubMed id 20219923)¹ Briones M.S....Chow S.A. (2010)
35. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
36. CKS proteins protect mitochondrial genome integrity b y interacting with mitochondrial single-stranded DNA-binding protein. (PubMed id 19786724)¹ Radulovic M....Yu V.P. (2010)
37. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. (PubMed id 20013084)¹ Thorpe J.A. and Schwarze S.R. (2010)
38. Artemis regulates cell cycle recovery from the S phas e checkpoint by promoting degradation of cyclin E. (PubMed id 19423708)¹ Wang H....Legerski R.J. (2009)
39. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)¹ Cunningham J.M....Fridley B.L. (2009)
40. Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia. (PubMed id 18692784)¹ Haraguchi T....Fujisawa M. (2009)
41. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. (PubMed id 19270695)¹ Gao D....Wei W. (2009)
42. Cdh1 regulates cell cycle through modulating the clas pin/Chk1 and the Rb/E2F1 pathways. (PubMed id 19477924)¹ Gao D....Wei W. (2009)
43. Methylation markers for CCNA1 and C13ORF18 are strong ly associated with high-grade cervical intraepithelial neoplasia and cervical c ancer in cervical scrapings. (PubMed id 19843677)¹ Yang N....Wisman G.B. (2009)
44. Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events. (PubMed id 18372919)¹ De Boer L....Gabrielli B. (2008)
45. Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing. (PubMed id 17308064)¹ Ji P....Zhu L. (2007)
46. Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1. (PubMed id 17098733)¹ Pilkinton M....Colamonici O.R. (2007)
47. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. (PubMed id 17274640)¹ Flores-Delgado G....Berndt N. (2007)
48. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
49. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. (PubMed id 16777603)¹ Zhang X....Kuriyan J. (2006)
50. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. (PubMed id 16774918)¹ Ji P....Zhu L. (2006)
51. Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells. (PubMed id 16519687)¹ Komamura-Kohno Y....Ishimi Y. (2006)
52. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PubMed id 17047026)¹ Yatsenko A.N....Matzuk M.M. (2006)
53. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
54. Biochemical characterization of Cdk2-Speedy/Ringo A2. (PubMed id 16191191)¹ Cheng A....Solomon M.J. (2005)
55. The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. (PubMed id 15649124)¹ Barberis M....Alberghina L. (2005)
56. Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. (PubMed id 15829981)¹ Ji P....Muller-Tidow C. (2005)
57. Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator. (PubMed id 15601848)¹ Narayanan R....Weigel N.L. (2005)
58. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. (PubMed id 16159883)¹ Niida H....Nakanishi M. (2005)
59. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
60. Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. (PubMed id 14701826)¹ Harwell R.M....Keyomarsi K. (2004)
61. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
62. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. (PubMed id 15004027)¹ Liu E....Wu X. (2004)
63. Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. (PubMed id 15138268)¹ Nishitani H....Nishimoto T. (2004)
64. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
65. Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. (PubMed id 14681231)¹ Shen W.H....Kelley K.W. (2004)
66. The cyclin A1-CDK2 complex regulates DNA double-strand break repair. (PubMed id 15456866)¹ Muller-Tidow C....Serve H. (2004)
67. Self-assembling protein microarrays. (PubMed id 15232106)¹ Ramachandran N....LaBaer J. (2004)
68. Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein. (PubMed id 15050687)¹ Zhou B.Y. and He J.J. (2004)
69. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
70. CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. (PubMed id 12800980)¹ Peiretti A....Ffrench M. (2003)
71. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. (PubMed id 12628165)¹ Staropoli J.F....Abeliovich A. (2003)
72. Direct activation of cyclin-dependent kinase 2 by huma n papillomavirus E7. (PubMed id 12970441)¹ He W....Fisher C. (2003)
73. Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A. (PubMed id 12383116)¹ Zheleva D.I....Lane D.P. (2002)
74. Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. (PubMed id 12190313)¹ Kim K.S....Webster K.R. (2002)
75. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. (PubMed id 11884610)¹ Leng X.... Harper J.W. (2002)
76. Quantification of cyclin A1 and glyceraldehyde-3-phosphate dehydrogenase expression in testicular biopsies of infertile patients by fluorescence real-time RT-PCR. (PubMed id 12121569)¹ Schrader M....Miller K. (2002)
77. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
78. Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). (PubMed id 11584018)¹ Santaguida M....Nepveu A. (2001)
79. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. (PubMed id 11340163)¹ Sorensen C.S....Lukas J. (2001)
80. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)¹ Yamochi T....Matsuoka M. (2001)
81. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. (PubMed id 11598016)¹ Fojas de Borja P....Mudryj M. (2001)
82. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)
83. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. (PubMed id 10995387)¹ Ma T....Harper J.W. (2000)
84. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. (PubMed id 10652300)¹ Yam C.H....Poon R.Y. (2000)
85. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. (PubMed id 10926775)¹ Liu D....Wolgemuth D.J. (2000)
86. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. (PubMed id 10679238)¹ Ohtoshi A....Hatakeyama M. (2000)
87. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. (PubMed id 10790373)¹ Nakayama K....Hatakeyama S. (2000)
88. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)
89. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. (PubMed id 10373534)¹ Ruffner H....Verma I.M. (1999)
90. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (PubMed id 10559988)¹ Brown N.R....Johnson L.N. (1999)
91. Cyclin A1 is required for meiosis in the male mouse. (PubMed id 9843212)¹ Liu D....Wolgemuth D.J. (1998)
92. The cyclin-dependent kinase inhibitor p27(Kip1) induce s N-terminal proteolytic cleavage of cyclin A. (PubMed id 9860976)¹ Bastians H....Ruderman J.V. (1998)
93. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PubMed id 9663463)¹ Michel J.J. and Xiong Y. (1998)
94. Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. (PubMed id 9636170)¹ Lyapina S.A....Deshaies R.J. (1998)
95. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. (PubMed id 9244350)¹ Wang H....Rao V.N. (1997)
96. Cyclin-binding motifs are essential for the function of p21CIP1. (PubMed id 8756624)¹ Chen J....Dutta A. (1996)
97. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. (PubMed id 7799941)¹ Desai D....Morgan D.O. (1995)
98. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. (PubMed id 7478582)¹ Hall M....Peters G. (1995)
99. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)¹ Xu M.... Piwnica-Worms H. (1994)
100. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
101. Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. (PubMed id 8397207)¹ Pan Z.Q....Hurwitz J. (1993)
102. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. (PubMed id 8463339)¹ O'Connor P.M....Kohn K.W. (1993)
103. Reconstitution of cyclin-dependent cdc2 and cdk2 kinase activities in vitro. (PubMed id 8397206)¹ Pan Z.Q. and Hurwitz J. (1993)
104. Distinct forms of human CDC2 identified by novel monoclonal antibodies. (PubMed id 1628647)¹ Lukas J....Bartek J. (1992)
105. The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. (PubMed id 11090075)⁹ Muller C....Koeffler H.P. (2000)
106. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. (PubMed id 10590070)⁹ Muller C....Koeffler H.P. (1999)
107. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. (PubMed id 18027847)⁹ Wegiel B....Persson J.L. (2008)
108. Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. (PubMed id 16004607)⁹ Ekberg J....Persson J.L. (2005)
109. Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis. (PubMed id 16517207)⁹ Ekberg J....Persson J.L. (2006)
110. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. (PubMed id 10757815)⁹ Muller C....Koeffler H.P. (2000)
111. Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. (PubMed id 16182364)⁹ Holm C....Persson J.L. (2006)
112. Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer. (PubMed id 16524460)⁹ Kitkumthorn N....Mutirangura A. (2006)
113. Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker. (PubMed id 12202422)⁹ Schrader M....Miller K. (2002)
114. Mutant p53 and cyclin A1 protein expression in primary laryngeal squamous cell carcinomas do not correlate to second primary tumours of the head and neck. (PubMed id 19183379)⁹ Farhadieh R.D....Russell P.J. (2009)
115. Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. (PubMed id 18559500)⁹ Jang S.W....Ye K. (2008)
116. Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells. (PubMed id 15489899)⁹ Ekberg J....Persson J.L. (2004)
117. Elevated levels of cyclin A1 and A (A2) mRNA in acute myeloid leukaemia are associated with increased survival. (PubMed id 14510945)⁹ Nakamaki T....Koeffler P. (2003)
118. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation. (PubMed id 9639417)⁹ Kramer A....Hehlmann R. (1998)
119. Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA. (PubMed id 16984381)⁹ Cho N.H....Cho S.H. (2006)
120. IgH and TCRgamma gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias. (PubMed id 16102826)⁹ Golemovic M....Batinic D. (2006)
121. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. (PubMed id 14696091)⁹ Liao C....Wolgemuth D.J. (2004)
122. A novel testis protein, RSB-66, interacting with INCA 1 (inhibitor of Cdk interacting with cyclin A1). (PubMed id 18756329)⁹ Chen X....Wang L. (2008)
123. Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. (PubMed id 18381426)⁹ Coletta R.D....Ford H.L. (2008)
124. Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. (PubMed id 17371803)⁹ Niklaus A.L....Santoro N.F. (2007)
125. [Inhibitory effect of WT1 gene isoform transfection on proliferation of leukemia cell line NB4] (PubMed id 16480579)⁹ Shen H.L....Zhao Y. (2006)
126. Regulation of the cyclin D1 and cyclin A1 promoters by B-Myb is mediated by Sp1 binding sites. (PubMed id 15922873)⁹ Bartusel T....Klempnauer K.H. (2005)
127. Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function. (PubMed id 15215197)⁹ Lele K.M. and Wolgemuth D.J. (2004)
128. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. (PubMed id 15526363)⁹ Xu X.L....Zhu J.D. (2004)
129. Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. (PubMed id 11212263)⁹ Muller-Tidow C....Serve H. (2001)
130. In vivo regulation of the early embryonic cell cycle in Xenopus. (PubMed id 8606001)⁹ Hartley R.S....Maller J.L. (1996)
131. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. (PubMed id 19582787)⁹ Kwok S....Selvamurugan N. (2009)
132. The proto-oncogene expression varies over the course of chronic myeloid leukemia. (PubMed id 18534064)⁹ Vidovic A....Boskovic D. (2008)
133. The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. (PubMed id 18347248)⁹ Shaw R.J....Risk J.M. (2008)
134. [Expression of cell cycle control genes in myelodysplastic syndromes.] (PubMed id 15946501)⁹ Shi J....Tu M.F. (2005)
135. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. (PubMed id 15737994)⁹ Katabami M....Birrer M.J. (2005)
136. The A-type cyclins and the meiotic cell cycle in mammalian male germ cells. (PubMed id 15271198)⁹ Wolgemuth D.J....Salazar G. (2004)
137. Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle. (PubMed id 9272959)⁹ Stack J.H. and Newport J.W. (1997)
138. Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus. (PubMed id 9243501)⁹ Anderson J.A....Maller J.L. (1997)
139. RUNX2 regulates the effects of TNFalpha on proliferat ion and apoptosis in SaOs-2 cells. (PubMed id 20053387)⁹ Olfa G....Jean-Christophe D. (2010)
140. The human RNA polymerase II-associated factor 1 (hPaf 1): a new regulator of cell-cycle progression. (PubMed id 19771162)⁹ Moniaux N....Batra S.K. (2009)
141. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. (PubMed id 19258499)⁹ Pigazzi M....Basso G. (2009)
142. [Influence of DNAzymes against cyclin D1 in tumor cel l cycle] (PubMed id 19499806)⁹ Li D....Liu X. (2009)
143. Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants. (PubMed id 18697815)⁹ Restle A....Wiesmuller L. (2008)
144. Pheophorbide a, an active component in Scutellaria barbata, reverses P-glycoprotein-mediated multidrug resistance on a human hepatoma cell line R-HepG2. (PubMed id 17457045)⁹ Tang P.M....Fung K.P. (2007)
145. Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. (PubMed id 17168675)⁹ Narayanan B.A. (2006)
146. The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. (PubMed id 16301204)⁹ Arnold K....Schwede T. (2006)
147. Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing. (PubMed id 16807314)⁹ Shaw R.J....Liloglou T. (2006)
148. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. (PubMed id 15800920)⁹ Diederichs S....Muller-Tidow C. (2005)
149. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. (PubMed id 15668976)⁹ Jiang Y.M....Sobue G. (2005)
150. Therapeutic targets for HIV-1 infection in the host proteome. (PubMed id 15780141)⁹ Liang W.S....Kashanchi F. (2005)
151. Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. (PubMed id 15492278)⁹ Kokkinakis D.M....Luo J. (2004)
152. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (PubMed id 15367334)⁹ Yu J....Zhu J. (2004)
153. E- and A-type cyclins as markers for cancer diagnosis and prognosis. (PubMed id 14510182)⁹ Yasmeen A....Muller-Tidow C. (2003)
154. Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. (PubMed id 14672555)⁹ Yu J....Zhu J.D. (2003)

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