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CCNA1 Gene

protein-coding   GIFtS: 65
GCID: GC13P037005

Cyclin A1

  See CCNA1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Cyclin A11 2

External Ids:    HGNC: 15771   Entrez Gene: 89002   Ensembl: ENSG000001331017   OMIM: 6040365   UniProtKB: P783963   

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNA1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and
brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the
germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase
activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This
cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor
E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA1 Gene:
CCNA1 (cyclin A1) is a protein-coding gene. Diseases associated with CCNA1 include male germ cell tumor, and acute myeloid leukemia. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
cell cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNA1 gene promoter:
         MyoD   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNA1 promoter sequence
   Search Chromatin IP Primers for CCNA1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037005:  view genomic region     (about GC identifiers)

37,005,967 bp from pter      End:
37,017,019 bp from pter
11,053 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)
Recommended Name: Cyclin-A1  
Size: 465 amino acids; 52358 Da
Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme
complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro).
The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with
CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9
Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M
Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91
Alternative splicing: 3 isoforms:  P78396-1   P78396-2   P78396-3   

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Explore proteomics data for CCNA1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its
    degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase1
  • Modification sites at neXtProt

  • See CCNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001104515.1  NP_001104516.1  NP_001104517.1  NP_003905.1  

    ENSEMBL proteins: 
     ENSP00000255465   ENSP00000396479   ENSP00000400666   ENSP00000409873  
    Reactome Protein details: P78396

    CCNA1 Human Recombinant Protein Products:

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    OriGene Purified Protein for CCNA1
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    OriGene MassSpec for CCNA1
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    Novus Biologicals CCNA1 Protein
    Novus Biologicals CCNA1 Lysate
    Sino Biological Recombinant Protein for CCNA1
    Sino Biological Cell Lysate for CCNA1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNA1

    Search eBioscience for Proteins for CCNA1 

    Search GeneTex for Proteins for CCNA1 

    antibodies-online proteins for CCNA1 (6 products) 

    antibodies-online peptides for CCNA1

    CCNA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
    R&D Systems Antibodies for CCNA1 (Cyclin A1)
    OriGene Antibodies for CCNA1
    OriGene Custom Antibody Services for CCNA1
    Novus Biologicals CCNA1 Antibodies
    Abcam antibodies for CCNA1
    Cloud-Clone Corp. Antibodies for CCNA1
    ThermoFisher Antibody for CCNA1
    antibodies-online antibodies for CCNA1 (54 products) 

    CCNA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNA1
    Cloud-Clone Corp. CLIAs for CCNA1
    Search eBioscience for ELISAs for CCNA1 
    antibodies-online kits for CCNA1 (9 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR015453 Cyclin_A
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P78396

    ProtoNet protein and cluster: P78396

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily

    Find genes that share domains with CCNA1           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNA1_HUMAN, P78396
    Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
    primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
    cell cycle in some somatic cells

         Genatlas biochemistry entry for CCNA1:
    cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell
    lines,regulator of cell-cycle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0019901protein kinase binding IEA--
    Find genes that share ontologies with CCNA1           About GenesLikeMe

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccna1):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with CCNA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccna1tm1Djw for CCNA1

       genOway: Develop your customized and physiologically relevant rodent model for CCNA1

        Search Taconic Biosciences for animal models for CCNA1 

    miRTarBase miRNAs that target CCNA1:
    hsa-mir-335-5p (MIRT018229), hsa-mir-124-3p (MIRT022823), hsa-let-7b-5p (MIRT032444)

    Block miRNA regulation of human, mouse, rat CCNA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCNA1:
    SwitchGear 3'UTR luciferase reporter plasmidCCNA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for CCNA1
    Predesigned siRNA for gene silencing in human, mouse, rat CCNA1

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for CCNA1

    OriGene clones in human, mouse for CCNA1 (see all 25)
    OriGene ORF clones in mouse, rat for CCNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
    Sino Biological Human cDNA Clone for CCNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for CCNA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNA1 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    CCNA1_HUMAN, P78396: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 


    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS9041194
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with CCNA1           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for CCNA1 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle Cell cycle (generic schema)
    Cell cycle Cell cycle (generic schema)0.38
    G2 Phase0.00
    Cell cycle Regulation of G1/S transition (part 2)0.38
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    DNA Replication0.92
    Regulation of mitotic cell cycle0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cyclin E associated events during G1/S transition0.86
    Switching of origins to a post-replicative state0.93
    Removal of licensing factors from origins0.86
    5Cellular Senescence
    Cellular Senescence0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    Cellular responses to stress0.81

    Find genes that share SuperPaths with CCNA1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNA1 (see all 9)
        Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling
    Breast Cancer Regulation by Stathmin1
    G1-S Phase Transition
    Estrogen-mediated S-Phase Entry

    Selected GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cell cycle Chromosome condensation in prometaphase
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of APC in cell cycle regulation

    5 BioSystems Pathways for CCNA1
        Cell cycle
    G1 to S cell cycle control
    AMPK signaling
    Gastric cancer network 1
    C-MYB transcription factor network

    Selected Reactome Pathways for CCNA1 (see all 12)
        SCF(Skp2)-mediated degradation of p27/p21
    G0 and Early G1
    Orc1 removal from chromatin
    E2F mediated regulation of DNA replication
    G1/S-Specific Transcription

    Selected Kegg Pathways  (Kegg details for CCNA1) (see all 8):
        Cell cycle
    Progesterone-mediated oocyte maturation
    Hepatitis B
    Epstein-Barr virus infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat


        GeneGlobe Interaction Network for CCNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNA1 (P783961, 2, 3 ENSP000002554654) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM4P339912, 3, ENSP000002621054MINT-50427 I2D: score=4 STRING: ENSP00000262105
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    Find genes that share ontologies with CCNA1           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNA1

    2 Novoseek inferred chemical compound relationships for CCNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 22.1 20 16517207 (6), 11090075 (4), 15489899 (2)
    vegf 16.9 14 16007189 (7), 18612129 (5), 18534064 (1)

    Find genes that share compounds with CCNA1           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts): 
    NM_001111045.1  NM_001111046.1  NM_001111047.1  NM_003914.3  

    Unigene Cluster for CCNA1:

    Cyclin A1
    Hs.417050  [show with all ESTs]
    Unigene Representative Sequence: NM_003914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463403 ENST00000255465 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)
    ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

    Block miRNA regulation of human, mouse, rat CCNA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCNA1:
    SwitchGear 3'UTR luciferase reporter plasmidCCNA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for CCNA1
    Predesigned siRNA for gene silencing in human, mouse, rat CCNA1
    OriGene clones in human, mouse for CCNA1 (see all 25)
    OriGene ORF clones in mouse, rat for CCNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1
    OriGene qPCR primer pairs and template standards for CCNA1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNA1
      QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
      QuantiFast Probe-based Assays in human, mouse, rat CCNA1

    Additional mRNA sequence: 

    AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1 

    3 DOTS entries:

    DT.113428  DT.75122607  DT.95165865 

    Selected AceView cDNA sequences (see all 68):

    F13244 BC035479 CR616879 BE336946 BC036346 AI168235 BM552862 F10846 
    AA420962 AA421060 F10700 AA777001 CN480841 BX281383 BI825398 BE242314 
    BI462532 AW237229 CD171793 BG720085 BI459787 BE242234 BI770824 BP369757 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP3:                    -     -                                                                     
    SP4:                    -     -                                                                     
    SP5:        -     -     -     -                                                                     

    ECgene alternative splicing isoforms for CCNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CCNA1 Expression
    About this image

    CCNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     Testis (Reproductive System)
             Seminiferous Tubules
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    CCNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.417050

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    OriGene qPCR primer pairs and template standards for CCNA1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNA1
    QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
    QuantiFast Probe-based Assays in human, mouse, rat CCNA1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNA1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ccna11 , 5 cyclin A11, 5 83.37(n)1
      3 (26.52 cM)5
    124271  NM_007628.31  NP_031654.21 
    (Gallus gallus)
    Aves CCNA11 cyclin A1 69.89(n)
      418901  XM_417097.4  XP_417097.1 
    (Anolis carolinensis)
    Reptilia CCNA16
    cyclin A1
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978852 Xenopus mRNA for cyclin A1 73.47(n)    X53745.1 
    (Danio rerio)
    Actinopterygii ccna11 cyclin A1 61.03(n)
      404206  NM_212818.1  NP_997983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycA3 mitosis cyclin-dependent protein
    kinase, regulator
    41(a)   68E1   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCA3;21 CYCA3;2 53.16(n)
      841124  NM_103614.4  NP_564499.3 
    (Oryza sativa)
    Liliopsida AK063476.12   -- 77.16(n)    AK063476.1 

    ENSEMBL Gene Tree for CCNA1 (if available)
    TreeFam Gene Tree for CCNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for CCNA1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCND22  CCNA22  
    1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries:     CCNA1_HUMAN (see all proteins):

    Find genes that share paralogs with CCNA1           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for CCNA1 (see all 325)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 13 posSequence#AA
    C,F--37003968(+) GGTCTG/CGATCT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    C,F--37003990(+) GATTCG/ACCTGC 2 -- us2k16Minor allele frequency- A:0.21NA CSA WA EA 364
    F--37004127(+) ACACAT/GAGATA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    C,F--37004131(+) ATAGAT/CATCAG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    C,F--37004279(+) AAAAAG/CATGTT 2 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    --37004595(+) GACAGG/TTTCCA 4 -- us2k10--------
    --37004684(+) AATCAA/GATGAA 4 -- us2k10--------
    C--37004716(-) GCTCAC/GGAGAC 4 -- us2k110Minor allele frequency- G:0.14NA EA WA 726
    C,F--37004787(-) ACTCCG/TTCTGG 4 -- us2k11Minor allele frequency- T:0.03EA 120
    --37004901(+) AAATGC/TTCCTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899993CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 604036    OMIM disorders: --

    2 diseases for CCNA1:    
    About MalaCards
    male germ cell tumor    acute myeloid leukemia

    1 inferred disease relationship from the University of Copenhagen DISEASES database for CCNA1:
    Acute myeloid leukemia

    Find genes that share disorders with CCNA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCNA1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 53 5 11381140 (2), 11090075 (1), 10590070 (1)
    leukemia 34.3 17 19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
    leukemia promyelocytic acute 27.2 3 11090075 (3)
    testicular cancer 26.5 1 14510182 (1)
    retinoblastoma 25 3 17455244 (3)
    tumors 24.6 19 18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
    wilms tumor 23.4 2 15526363 (1)
    osteosarcoma 22.7 1 10757815 (1)
    cancer 14.1 5 11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
    lymphoblastic leukemia acute 8.84 1 16102826 (1)

    Genetic Association Database (GAD): CCNA1
    Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

    Export disorders for CCNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNA1 gene, integrated from 10 sources (see all 178) (see top 10):
    (articles sorted by number of sources associating them with CCNA1)

    1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)1, 2, 3, 9 Yang R.... Koeffler H.P. (Cancer Res. 1997)
    2. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)1, 2, 9 Yang R.... Koeffler H.P. (Mol. Cell. Biol. 1999)
    3. Mutations of the cyclin A1 gene are not a common cause of male infertility. (PubMed id 19886767)1, 4, 9 Zhoucun A....Yang Y. (Syst Biol Reprod Med 2009)
    4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    5. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)1, 2 Diederichs S.... Mueller-Tidow C. (J. Biol. Chem. 2004)
    6. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)1, 9 Wegiel B....Persson J.L. (J. Natl. Cancer Inst. 2008)
    7. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)1, 9 Wegiel B....Persson J.L. (Oncogene 2005)
    8. DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)1, 9 Ji P....MA1ller-Tidow C. (Int. J. Cancer 2007)
    9. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)1, 9 Liao C....Wolgemuth D.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)1, 9 Yang R....Koeffler H.P. (Blood 1999)
    11. NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. (PubMed id 19668232)1, 9 Chan C.B....Ye K. (Oncogene 2009)
    12. Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells. (PubMed id 18787932)1, 9 Ekberg J. and Persson J.L. (Mol. Cell. Biochem. 2009)
    13. Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. (PubMed id 16799873)1, 9 Rivera A....Maxwell S.A. (Cell. Mol. Life Sci. 2006)
    14. Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology. (PubMed id 11172814)1, 9 MA1ller-Tidow C....Serve H. (FEBS Lett. 2001)
    15. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. (PubMed id 11264176)1, 9 MA1ller-Tidow C....Koeffler H.P. (Blood 2001)
    16. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. (PubMed id 10196209)1, 9 Muller C....Koeffler H.P. (J. Biol. Chem. 1999)
    17. A distinct cyclin A is expressed in germ cells in the mouse. (PubMed id 8565853)1, 9 Sweeney C....Carrington M. (Development 1996)
    18. Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2. (PubMed id 19056339)1, 9 Joshi A.R....Wolgemuth D.J. (Biochem. Biophys. Res. Commun. 2009)
    19. Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice. (PubMed id 12579332)1, 9 MA1ller-Tidow C....Koeffler H.P. (Int. J. Mol. Med. 2003)
    20. [Expression of cyclin A1 mRNA in patients with myelodysplastic syndrome and its clinical significance]. (PubMed id 19379570)1, 9 Jia J.S. and Xu S.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    21. The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells. (PubMed id 17530187)1, 9 Yang D....Zhou Z. (Mol. Cell. Biochem. 2007)
    22. Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. (PubMed id 16449996)1, 9 Shaw R.J....Risk J.M. (Br. J. Cancer 2006)
    23. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. (PubMed id 15342377)1, 9 Tokumaru Y....Sidransky D. (Cancer Res. 2004)
    24. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. (PubMed id 10068472)1, 9 Ravnik S.E. and Wolgemuth D.J. (Dev. Biol. 1999)
    25. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PubMed id 20457893)1, 9 Hsia D.A.... Izumiya Y. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    26. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. (PubMed id 23972993)1 Fukushima H....Wei W. (Cell Rep 2013)
    27. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    28. Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. (PubMed id 24145166)1 Lu A. and Pfeffer S.R. (J. Cell Biol. 2013)
    29. Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16. (PubMed id 22712549)1 Weiss D....Rudack C. (BMC Cancer 2012)
    30. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. (PubMed id 22529286)1 Ochsenreither S....Greenberg P.D. (Blood 2012)
    31. Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells. (PubMed id 23042265)1 Kloc M....Ghobrial R.M. (Folia Histochem. Cytobiol. 2012)
    32. Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies. (PubMed id 22718346)1 Marlow L.A....Copland J.A. (J. Cell. Sci. 2012)
    33. Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features. (PubMed id 22763964)1 Alekseenko A....Litwin J.A. (Folia Histochem. Cytobiol. 2012)
    34. The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. (PubMed id 22370483)1 Kim J....Freeman M.R. (Cell Cycle 2012)
    35. Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells. (PubMed id 22500553)1 McLenachan S....Edel M.J. (Stem Cells Dev. 2012)
    36. Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer. (PubMed id 21412159)1 Yanatatsaneejit P....Kitkumthorn N. (Int. J. Gynecol. Cancer 2011)
    37. Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation. (PubMed id 21563216)1 Weiss D....Rudack C. (Mol. Carcinog. 2011)
    38. Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB. (PubMed id 21764057)1 MaziA"re C....MaziA"re J.C. (Atherosclerosis 2011)
    39. MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis. (PubMed id 21646351)1 Tian R.Q....Tang H. (J. Biol. Chem. 2011)
    40. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)2 Huang X.... Dixit V.M. (Mol. Cell 2011)
    41. Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core. (PubMed id 20219923)1 Briones M.S....Chow S.A. (J. Virol. 2010)
    42. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    43. CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein. (PubMed id 19786724)1 Radulovic M....Yu V.P. (amp 2010)
    44. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. (PubMed id 20013084)1 Thorpe J.A. and Schwarze S.R. (amp 2010)
    45. Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. (PubMed id 19423708)1 Wang H....Legerski R.J. (J. Biol. Chem. 2009)
    46. Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia. (PubMed id 18692784)1 Haraguchi T....Fujisawa M. (Fertil. Steril. 2009)
    47. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. (PubMed id 19270695)1 Gao D....Wei W. (Nat. Cell Biol. 2009)
    48. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. (PubMed id 19477924)1 Gao D....Wei W. (Mol. Biol. Cell 2009)
    49. Methylation markers for CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical scrapings. (PubMed id 19843677)1 Yang N....Wisman G.B. (amp 2009)
    50. Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events. (PubMed id 18372919)1 De Boer L.... Gabrielli B. (Oncogene 2008)
    51. Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing. (PubMed id 17308064)1 Ji P....Zhu L. (Mol. Cancer Ther. 2007)
    52. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    53. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    54. Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1. (PubMed id 17098733)1 Pilkinton M....Colamonici O.R. (J. Biol. Chem. 2007)
    55. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. (PubMed id 17274640)1 Flores-Delgado G....Berndt N. (J. Proteome Res. 2007)
    56. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    57. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. (PubMed id 16777603)1 Zhang X....Kuriyan J. (Cell 2006)
    58. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. (PubMed id 16774918)1 Ji P....Zhu L. (J. Biol. Chem. 2006)
    59. Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells. (PubMed id 16519687)1 Komamura-Kohno Y....Ishimi Y. (FEBS J. 2006)
    60. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PubMed id 17047026)1 Yatsenko A.N....Matzuk M.M. (Hum. Mol. Genet. 2006)
    61. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    62. Biochemical characterization of Cdk2-Speedy/Ringo A2. (PubMed id 16191191)1 Cheng A....Solomon M.J. (BMC Biochem. 2005)
    63. The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. (PubMed id 15649124)1 Barberis M....Alberghina L. (Biochem. J. 2005)
    64. Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. (PubMed id 15829981)1 Ji P....MA1ller-Tidow C. (Oncogene 2005)
    65. A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. (PubMed id 16009130)1 Rohaly G....Dornreiter I. (Cell 2005)
    66. Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator. (PubMed id 15601848)1 Narayanan R....Weigel N.L. (Mol. Cell. Biol. 2005)
    67. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. (PubMed id 16159883)1 Niida H....Nakanishi M. (J. Biol. Chem. 2005)
    68. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    69. Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. (PubMed id 14701826)1 Harwell R.M....Keyomarsi K. (J. Biol. Chem. 2004)
    70. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    71. Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. (PubMed id 14985333)1 Park C.S....Song W.K. (J. Biol. Chem. 2004)
    72. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. (PubMed id 15004027)1 Liu E....Wu X. (J. Biol. Chem. 2004)
    73. Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. (PubMed id 15138268)1 Nishitani H....Nishimoto T. (J. Biol. Chem. 2004)
    74. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    75. Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. (PubMed id 15583032)1 Thomas D.M....Hinds P.W. (J. Cell Biol. 2004)
    76. Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. (PubMed id 14681231)1 Shen W.H....Kelley K.W. (J. Biol. Chem. 2004)
    77. The cyclin A1-CDK2 complex regulates DNA double-strand break repair. (PubMed id 15456866)1 MA1ller-Tidow C....Serve H. (Mol. Cell. Biol. 2004)
    78. Self-assembling protein microarrays. (PubMed id 15232106)1 Ramachandran N....LaBaer J. (Science 2004)
    79. Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein. (PubMed id 15050687)1 Zhou B.Y. and He J.J. (Neurosci. Lett. 2004)
    80. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    81. CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. (PubMed id 12800980)1 Peiretti A....Ffrench M. (Eur. J. Cell Biol. 2003)
    82. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. (PubMed id 12628165)1 Staropoli J.F....Abeliovich A. (Neuron 2003)
    83. Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7. (PubMed id 12970441)1 He W....Fisher C. (J. Virol. 2003)
    84. Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A. (PubMed id 12383116)1 Zheleva D.I....Lane D.P. (J. Pept. Res. 2002)
    85. Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. (PubMed id 12190313)1 Kim K.S....Webster K.R. (J. Med. Chem. 2002)
    86. Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. (PubMed id 12191604)1 Johnson L.N....Noble M.E. (amp 2002)
    87. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. (PubMed id 11884610)1 Leng X.... Harper J.W. (Mol. Cell. Biol. 2002)
    88. Quantification of cyclin A1 and glyceraldehyde-3-phosphate dehydrogenase expression in testicular biopsies of infertile patients by fluorescence real-time RT-PCR. (PubMed id 12121569)1 Schrader M....Miller K. (Int. J. Androl. 2002)
    89. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    90. Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication. (PubMed id 11259605)1 Dehde S....Dornreiter I. (Mol. Cell. Biol. 2001)
    91. Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. (PubMed id 11310559)1 Freire J....Freire M. (Biochem. Cell Biol. 2001)
    92. Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). (PubMed id 11584018)1 Santaguida M....Nepveu A. (J. Biol. Chem. 2001)
    93. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. (PubMed id 11340163)1 SA...Lukas J. (Mol. Cell. Biol. 2001)
    94. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1 Yamochi T....Matsuoka M. (Eur. J. Biochem. 2001)
    95. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. (PubMed id 11598016)1 Fojas de Borja P....Mudryj M. (EMBO J. 2001)
    96. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    97. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. (PubMed id 10995387)1 Ma T.... Harper J.W. (Genes Dev. 2000)
    98. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. (PubMed id 10652300)1 Yam C.H....Poon R.Y. (J. Biol. Chem. 2000)
    99. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. (PubMed id 10926775)1 Liu D....Wolgemuth D.J. (Dev. Biol. 2000)
    100. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. (PubMed id 10679238)1 Ohtoshi A....Hatakeyama M. (Biochem. Biophys. Res. Commun. 2000)
    101. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. (PubMed id 10790373)1 Nakayama K....Hatakeyama S. (EMBO J. 2000)
    102. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)
    103. Phosphorylation of B-Myb regulates its transactivation potential and DNA binding. (PubMed id 10593981)1 Johnson T.K....Lewis R.E. (J. Biol. Chem. 1999)
    104. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. (PubMed id 10373534)1 Ruffner H....Verma I.M. (Mol. Cell. Biol. 1999)
    105. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (PubMed id 10559988)1 Brown N.R....Johnson L.N. (Nat. Cell Biol. 1999)
    106. Cyclin A1 is required for meiosis in the male mouse. (PubMed id 9843212)1 Liu D....Wolgemuth D.J. (Nat. Genet. 1998)
    107. The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A. (PubMed id 9860976)1 Bastians H....Ruderman J.V. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    108. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (PubMed id 9663463)1 Michel J.J. and Xiong Y. (Cell Growth Differ. 1998)
    109. Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. (PubMed id 9636170)1 Lyapina S.A....Deshaies R.J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    110. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. (PubMed id 9139732)1 Zarkowska T. and Mittnacht S. (J. Biol. Chem. 1997)
    111. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. (PubMed id 9244350)1 Wang H....Rao V.N. (Oncogene 1997)
    112. Cyclin-binding motifs are essential for the function of p21CIP1. (PubMed id 8756624)1 Chen J....Dutta A. (Mol. Cell. Biol. 1996)
    113. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. (PubMed id 7799941)1 Desai D....Morgan D.O. (Mol. Cell. Biol. 1995)
    114. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. (PubMed id 7478582)1 Hall M....Peters G. (Oncogene 1995)
    115. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. (PubMed id 7969176)1 Xu M.... Piwnica-Worms H. (Mol. Cell. Biol. 1994)
    116. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    117. Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. (PubMed id 8397207)1 Pan Z.Q....Hurwitz J. (J. Biol. Chem. 1993)
    118. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. (PubMed id 8463339)1 O'Connor P.M....Kohn K.W. (J. Biol. Chem. 1993)
    119. Reconstitution of cyclin-dependent cdc2 and cdk2 kinase activities in vitro. (PubMed id 8397206)1 Pan Z.Q. and Hurwitz J. (J. Biol. Chem. 1993)
    120. Distinct forms of human CDC2 identified by novel monoclonal antibodies. (PubMed id 1628647)1 LukA!s J....Bartek J. (Eur. J. Biochem. 1992)
    121. The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. (PubMed id 11090075)9 MA1ller C....Koeffler H.P. (Blood 2000)
    122. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. (PubMed id 10590070)9 MA1ller C....Koeffler H.P. (Blood 1999)
    123. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. (PubMed id 18027847)9 Wegiel B....Persson J.L. (Int. J. Cancer 2008)
    124. Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. (PubMed id 16004607)9 Ekberg J....Persson J.L. (Eur. J. Haematol. 2005)
    125. Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis. (PubMed id 16517207)9 Ekberg J....Persson J.L. (amp 2006)
    126. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. (PubMed id 10757815)9 MA1ller C....Koeffler H.P. (Mol. Cell. Biol. 2000)
    127. Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. (PubMed id 16182364)9 Holm C....Persson J.L. (Leuk. Res. 2006)
    128. Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer. (PubMed id 16524460)9 Kitkumthorn N....Mutirangura A. (BMC Cancer 2006)
    129. Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker. (PubMed id 12202422)9 Schrader M....Miller K. (Hum. Reprod. 2002)
    130. Mutant p53 and cyclin A1 protein expression in primary laryngeal squamous cell carcinomas do not correlate to second primary tumours of the head and neck. (PubMed id 19183379)9 Farhadieh R.D....Russell P.J. (ANZ J Surg 2009)
    131. Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. (PubMed id 18559500)9 Jang S.W.... Ye K. (Cancer Res. 2008)
    132. Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells. (PubMed id 15489899)9 Ekberg J....Persson J.L. (Oncogene 2004)
    133. Elevated levels of cyclin A1 and A (A2) mRNA in acute myeloid leukaemia are associated with increased survival. (PubMed id 14510945)9 Nakamaki T....Koeffler P. (Br. J. Haematol. 2003)
    134. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation. (PubMed id 9639417)9 KrAomer A....Hehlmann R. (Leukemia 1998)
    135. Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA. (PubMed id 16984381)9 Cho N.H....Cho S.H. (Cancer Sci. 2006)
    136. IgH and TCRgamma gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias. (PubMed id 16102826)9 GolemoviA8 M....BatiniA8 D. (Leuk. Res. 2006)
    137. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. (PubMed id 14696091)9 Liao C....Wolgemuth D.J. (Int. J. Cancer 2004)
    138. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). (PubMed id 18756329)9 Chen X....Wang L. (Biochem. Cell Biol. 2008)
    139. Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. (PubMed id 18381426)9 Coletta R.D....Ford H.L. (Cancer Res. 2008)
    140. Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. (PubMed id 17371803)9 Niklaus A.L....Santoro N.F. (Hum. Reprod. 2007)
    141. [Inhibitory effect of WT1 gene isoform transfection on proliferation of leukemia cell line NB4]. (PubMed id 16480579)9 Shen H.L....Zhao Y. (Ai Zheng 2006)
    142. Regulation of the cyclin D1 and cyclin A1 promoters by B-Myb is mediated by Sp1 binding sites. (PubMed id 15922873)9 Bartusel T....Klempnauer K.H. (Gene 2005)
    143. Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function. (PubMed id 15215197)9 Lele K.M. and Wolgemuth D.J. (Biol. Reprod. 2004)
    144. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. (PubMed id 15526363)9 Xu X.L....Zhu J.D. (World J. Gastroenterol. 2004)
    145. Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. (PubMed id 11212263)9 MA1ller-Tidow C....Serve H. (Cancer Res. 2001)
    146. In vivo regulation of the early embryonic cell cycle in Xenopus. (PubMed id 8606001)9 Hartley R.S....Maller J.L. (Dev. Biol. 1996)
    147. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. (PubMed id 19582787)9 Kwok S....Selvamurugan N. (J. Cell. Biochem. 2009)
    148. The proto-oncogene expression varies over the course of chronic myeloid leukemia. (PubMed id 18534064)9 VidoviA8 A....BoskoviA8 D. (Hematology 2008)
    149. The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. (PubMed id 18347248)9 Shaw R.J....Risk J.M. (amp 2008)
    150. [Expression of cell cycle control genes in myelodysplastic syndromes]. (PubMed id 15946501)9 Shi J....Tu M.F. (Zhonghua Xue Ye Xue Za Zhi 2005)
    151. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. (PubMed id 15737994)9 Katabami M....Birrer M.J. (J. Biol. Chem. 2005)
    152. The A-type cyclins and the meiotic cell cycle in mammalian male germ cells. (PubMed id 15271198)9 Wolgemuth D.J....Salazar G. (Int. J. Androl. 2004)
    153. Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle. (PubMed id 9272959)9 Stack J.H. and Newport J.W. (Development 1997)
    154. Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus. (PubMed id 9243501)9 Anderson J.A....Maller J.L. (Mol. Biol. Cell 1997)

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    Entrez Gene: 8900 HGNC: 1577 AceView: CCNA1 Ensembl:ENSG00000133101 euGenes: HUgn8900
    ECgene: CCNA1 Kegg: 8900 H-InvDB: CCNA1

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