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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNA1 Gene

protein-coding GIFtS: 65
GCID: GC13P037005

cyclin A1

Explore 39 diseases affiliated with
CCNA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin A1¹ ²
Cyclin-A1¹

External Ids:	HGNC: 1577¹	Entrez Gene: 8900²	Ensembl: ENSG00000133101⁷	OMIM: 604036⁵	UniProtKB: P78396³

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNA1:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in

several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle.

This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the

other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle

regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell

cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNA1 gene promoter:
MyoD IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNA1 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P037005: view genomic region (about GC identifiers)

Start:	37,005,967 bp from pter	End:	37,017,019 bp from pter
Size:	11,053 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)

Recommended Name: Cyclin-A1

Size: 465 amino acids; 52358 Da

Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The

cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin

A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and

CCNE1 (By similarity). Interacts with INCA1 and KLHDC9

Subcellular location: Nucleus (By similarity)

Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases

Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91

Alternative splicing: 3 isoforms: P78396-1 P78396-2 P78396-3

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Post-translational modifications:

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation

by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78396

CCNA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001104515.1 NP_001104516.1 NP_001104517.1 NP_003905.1

ENSEMBL proteins:

ENSP00000255465 ENSP00000396479 ENSP00000400666 ENSP00000409873

Reactome Protein details: P78396
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for CCNA1
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	Uscn Proteins for CCNA1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	9041194
GO:0015630	microtubule cytoskeleton	IDA	--

CCNA1 for ontologies About GeneDecksing

CCNA1 Antibody Products:

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	ThermoFisher Antibody for CCNA1

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	GenScript Custom Assay Services for CCNA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P78396

ProtoNet protein and cluster: P78396

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell

cycle in some somatic cells

Genatlas biochemistry entry for CCNA1:

cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell

lines,regulator of cell-cycle

miRNA Products:		OriGene 3'-UTR Clone (see all 4): CCNA1 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
		hsa-miR-656
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15232106
GO:0019901	protein kinase binding	IEA	--

CCNA1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ccna1^tm1Djw for CCNA1
     6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccna1):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	mortality/aging
reproductive system

CCNA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/16 pathways (see all 16)
Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75	Cyclin E associated events during G1/S transition	0.67
SCF(Skp2)-mediated degradation of p27/p21	0.75	Cyclin A:Cdk2-associated events at S phase entry	0.66
Switching of origins to a post-replicative state	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62
Orc1 removal from chromatin	0.70	Regulation of mitotic cell cycle	0.58

Cell cycle_Cell cycle (generic schema)

Cell cycle_Cell cycle (generic schema)	1.00	Cell cycle Regulation of G1/S transition (part 2)	0.38
Cell cycle Cell cycle (generic schema)	1.00	G0 and Early G1	0.31
Cell cycle_Regulation of G1/S transition (part 2)	0.38

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	1.00			G2 Phase	0.43
	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.60

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for CCNA1 (see all 10)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA1 (see all 9)

	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling
	Breast Cancer Regulation by Stathmin1
	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry

5/9 GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell cycle Chromosome condensation in prometaphase
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of APC in cell cycle regulation

4 BioSystems Pathways for CCNA1

	Cell cycle
	G1 to S cell cycle control
	AMPK signaling
	C-MYB transcription factor network

5/30 Reactome Pathways for CCNA1 (see all 30)

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	DNA Replication
	G0 and Early G1
	Removal of licensing factors from origins

4 Kegg Pathways (Kegg details for CCNA1):

	Cell cycle
	Progesterone-mediated oocyte maturation
	Pathways in cancer
	Acute myeloid leukemia

CCNA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/119 Interacting proteins for CCNA1 (P78396^{1, 2, 3} ENSP00000255465⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 119)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1A	P38936¹^,²^,³, ENSP00000244741⁴	EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
HIST2H3A	Q71DI3³	I2D: score=1
HIST2H3C	Q71DI3³	I2D: score=1
HIST2H3D	Q71DI3³	I2D: score=1
MCM4	P33991²^,³, ENSP00000262105⁴	MINT-50427 I2D: score=4 STRING: ENSP00000262105

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

CCNA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNA1
2 Novoseek chemical compound relationships for CCNA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	22.1	20	16517207 (6), 11090075 (4), 15489899 (2)
vegf	16.9	14	16007189 (7), 18612129 (5), 18534064 (1)

Search CenterWatch for drugs/clinical trials and news about CCNA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts):

NM_001111045.1 NM_001111046.1 NM_001111047.1 NM_003914.3

Unigene Cluster for CCNA1:

Cyclin A1

Hs.417050 [show with all ESTs]

Unigene Representative Sequence: NM_003914

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000463403 ENST00000255465 ENST00000491116 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)

ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
		hsa-miR-656
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Additional cDNA sequence:

AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1

U97680.1

3 DOTS entries:

DT.113428 DT.75122607 DT.95165865

24/68 AceView cDNA sequences (see all 68):

F13244 F10700 BM552862 CR616879 AA421060 BC036346 BE336946 BC035479

BX281383 F10846 AI168235 CN480841 AA777001 AA420962 BG722580 AI962852

AI637969 CA943295 CD171793 BE242314 BI560831 AW237229 BI770824 F13099

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:
SP3:							-		-
SP4:							-		-
SP5:			-		-		-		-

ECgene alternative splicing isoforms for CCNA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCACCTG

About this image

CCNA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCNA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNA1

SOURCE GeneReport for Unigene cluster: Hs.417050

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNA1 (see all 7):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Cytoskeleton Regulators in human mouse rat

Cell Cycle in human mouse rat

Breast Cancer in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA1 gene from 7/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCNA1¹	cyclin A1	69.9(n) 68.91(a)		418901 XM_417097.3 XP_417097.1
lizard (Anolis carolinensis)	Reptilia	CCNA1⁶	--	68(a)	1 ↔ 1	3(181636277-181651308)
African clawed frog (Xenopus laevis)	Amphibia	LOC397885²	Xenopus mRNA for cyclin A1	73.47(n)		X53745.1
zebrafish (Danio rerio)	Actinopterygii	ccna1¹	cyclin A1	61.06(n) 61.9(a)		404206 NM_212818.1 NP_997983.1
fruit fly (Drosophila melanogaster)	Insecta	CycA³	mitosis cyclin-dependent protein kinase, regulator	41(a)		68E1 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCA3;2¹	cyclin-A3-2	53.16(n) 45.83(a)		841124 NM_103614.4 NP_564499.3
rice (Oryza sativa)	Liliopsida	AK063476.1²	--	77.16(n)		AK063476.1

ENSEMBL Gene Tree for CCNA1 (if available)
TreeFam Gene Tree for CCNA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNA1 gene

CCND3² CCNO² CCNE1² CCNB2² CCNE2² CCNB3² CCNB1² CCND1²

CCND2² CCNA2²

1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries: CCNA1_HUMAN (see all proteins):

CCNA2

CCNA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113187087^1,2		--	37003968(+)	`GGTCTG/CGATCT`	2	--	us2k¹		1		CSA	2
rs71438100^1,2	C,F,	--	37003990(+)	`GATTCG/ACCTGC`	2	--	us2k¹		6		NA CSA WA EA	364
rs75649719^1,2	F,	--	37004127(+)	`ACACAT/GAGATA`	2	--	us2k¹		1		WA	118
rs115606274^1,2	C,F,	--	37004131(+)	`ATAGAT/CATCAG`	2	--	us2k¹		1		WA	118
rs112983504^1,2		--	37004279(+)	`AAAAAG/CATGTT`	2	--	us2k¹		2		CSA WA	120
rs147980980^1,2		--	37004595(+)	`GACAGG/TTTCCA`	4	--	us2k¹		0	--	--	--	--
rs141605253^1,2		--	37004684(+)	`AATCAA/GATGAA`	4	--	us2k¹		0	--	--	--	--
rs3814805^1,2	C,	--	37004716(-)	`GCTCAC/GGAGAC`	4	--	us2k¹		10		NA EA WA	726
rs3814804^1,2	C,F,	--	37004787(-)	`ACTCCG/TTCTGG`	4	--	us2k¹		1		EA	120
rs150512260^1,2		--	37004901(+)	`AAATGC/TTCCTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNA1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CCNA1 for disorders           About GeneDecksing

OMIM gene information: 604036    OMIM disorders: --

39 diseases for CCNA1 (see first 20):    About MalaCards

male germ cell tumor cervical intraepithelial neoplasia germ cell tumor amyotrophic lateral sclerosis

myeloid leukemia laryngeal squamous cell carcinoma lateral sclerosis lymphoblastic leukemia

wilms tumor acute promyelocytic leukemia squamous cell carcinoma male infertility

testicular cancer acute lymphoblastic leukemia acute myeloid leukemia chronic myeloid leukemia

leukemia myelodysplastic syndrome laryngitis ovarian cancer

infertility retinoblastoma azoospermia osteosarcoma

cervicitis breast cancer oral cancer acute leukemia

cervical cancer lung carcinoma lung cancer astrocytoma

carcinoma prostate cancer prostatitis immunodeficiency

neuronitis adenocarcinoma pancreatitis

1 disease from the University of Copenhagen DISEASES database for CCNA1:

Acute myeloid leukemia

10/13 Novoseek disease relationships for CCNA1 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	53	5	11381140 (2), 11090075 (1), 10590070 (1)
leukemia	34.3	17	19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
leukemia promyelocytic acute	27.2	3	11090075 (3)
testicular cancer	26.5	1	14510182 (1)
retinoblastoma	25	3	17455244 (3)
tumors	24.6	19	18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
wilms tumor	23.4	2	15526363 (1)
osteosarcoma	22.7	1	10757815 (1)
cancer	14.1	5	11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
lymphoblastic leukemia acute	8.84	1	16102826 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

Export disorders for CCNA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCNA1 gene, integrated from 9 sources (see all 162):
(articles sorted by number of sources associating them with CCNA1)

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Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)^{1, 2, 3, 9} Yang R.... Koeffler H.P. (1997)
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)^{1, 2, 9} Yang R.... Koeffler H.P. (1999)
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)^{1, 2} Diederichs S.... Mueller-Tidow C. (2004)
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)^{1, 9} Wegiel B....Persson J.L. (2008)
A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)^{1, 9} Wegiel B....Persson J.L. (2005)
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)^{1, 9} Ji P....Muller-Tidow C. (2007)
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)^{1, 9} Liao C....Wolgemuth D.J. (2001)
Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)^{1, 9} Yang R....Koeffler H.P. (1999)
NGF inhibits human leukemia proliferation by downregu lating cyclin A1 expression through promoting acinus/CtBP2 association. (PubMed id 19668232)^{1, 9} Chan C.B....Ye K. (2009)
Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells. (PubMed id 18787932)^{1, 9} Ekberg J. and Persson J.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8900	HGNC: 1577	AceView: CCNA1	Ensembl:ENSG00000133101	euGenes: HUgn8900
ECgene: CCNA1	Kegg: 8900	H-InvDB: CCNA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCNA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CCNA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCNA1 gene:
Search GeneIP for patents involving CCNA1

GeneCards and IP:
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