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CCNA1 Gene

protein-coding GIFtS: 65
GCID: GC13P037005

Cyclin A1

See CCNA1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Cyclin A1¹ ²
CT146²
cyclin-A1²

External Ids:	HGNC: 1577¹	Entrez Gene: 8900²	Ensembl: ENSG00000133101⁷	OMIM: 604036⁵	UniProtKB: P78396³

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNA1 Gene:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by

a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK

kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal

coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and

brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the

germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase

activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This

cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor

E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA1 Gene:

CCNA1 (cyclin A1) is a protein-coding gene. Diseases associated with CCNA1 include male germ cell tumor, and acute myeloid leukemia. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic

cell cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000013.10 NC_018924.2 NT_024524.15

Regulatory elements:

Regulatory transcription factor binding sites in the CCNA1 gene promoter:
MyoD IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNA1 promoter sequence

Search Chromatin IP Primers for CCNA1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P037005: view genomic region (about GC identifiers)

Start:	37,005,967 bp from pter	End:	37,017,019 bp from pter
Size:	11,053 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)

Recommended Name: Cyclin-A1

Size: 465 amino acids; 52358 Da

Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme

complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro).

The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with

CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9

Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M

phases

Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91

Alternative splicing: 3 isoforms: P78396-1 P78396-2 P78396-3

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Explore proteomics data for CCNA1 at MOPED

Post-translational modifications:

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its

degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase¹

Modification sites at neXtProt

See CCNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001104515.1 NP_001104516.1 NP_001104517.1 NP_003905.1

ENSEMBL proteins:

ENSP00000255465 ENSP00000396479 ENSP00000400666 ENSP00000409873

Reactome Protein details: P78396

CCNA1 Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for CCNA1 Sino Biological Cell Lysate for CCNA1
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CCNA1
	Search eBioscience for Proteins for CCNA1
	antibodies-online proteins for CCNA1 (6 products)
	antibodies-online peptides for CCNA1

CCNA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
	R&D Systems Antibodies for CCNA1 (Cyclin A1)
	OriGene Antibodies for CCNA1 OriGene Custom Antibody Services for CCNA1
	Novus Biologicals CCNA1 Antibodies
	Abcam antibodies for CCNA1
	Cloud-Clone Corp. Antibodies for CCNA1
	ThermoFisher Antibody for CCNA1
	antibodies-online antibodies for CCNA1 (54 products)

CCNA1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCNA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNA1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CCNA1 Cloud-Clone Corp. CLIAs for CCNA1
	Search eBioscience for ELISAs for CCNA1
	antibodies-online kits for CCNA1 (9 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C-dom

IPR015453 Cyclin_A

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P78396

ProtoNet protein and cluster: P78396

1 Blocks protein domain: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

Find genes that share domains with CCNA1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic

cell cycle in some somatic cells

Genatlas biochemistry entry for CCNA1:

cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell

lines,regulator of cell-cycle

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15232106
GO:0019901	protein kinase binding	IEA	--

Find genes that share ontologies with CCNA1 About GenesLikeMe

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccna1):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	mortality/aging
reproductive system

Find genes that share phenotypes with CCNA1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Ccna1^tm1Djw for CCNA1

genOway: Develop your customized and physiologically relevant rodent model for CCNA1

miRNA Products:		miRTarBase miRNAs that target CCNA1: hsa-mir-335-5p (MIRT018229), hsa-mir-124-3p (MIRT022823), hsa-let-7b-5p (MIRT032444)

		Block miRNA regulation of human, mouse, rat CCNA1 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate CCNA1:
		hsa-miR-656
		SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCNA1
		Predesigned siRNA for gene silencing in human, mouse, rat CCNA1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCNA1

Clone Products:		OriGene clones in human, mouse for CCNA1 (see all 25) OriGene ORF clones in mouse, rat for CCNA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
		Sino Biological Human cDNA Clone for CCNA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNA1
		Browse ESI BIO Cell Lines and PureStem Progenitors for CCNA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CCNA1_HUMAN, P78396: Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	4
cytosol	4
nucleus	4
mitochondrion	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	9041194
GO:0015630	microtubule cytoskeleton	IDA	--

Find genes that share ontologies with CCNA1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCNA1 About (see all 34)

See pathways by source

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SuperPath

Selected contained pathways About (see all per SuperPath)

Cell cycle Cell cycle (generic schema)

	Cell cycle Cell cycle (generic schema)	0.38			G2 Phase	0.00
	Cell cycle Regulation of G1/S transition (part 2)	0.38

Mitotic G1-G1/S phases

	Mitotic G1-G1/S phases	0.81			G1 to S cell cycle control	0.35
	G1/S Transition	0.81

Cell cycle

Cell cycle

0.59

Cell cycle

0.59

CDK-mediated phosphorylation and removal of Cdc6

APC/C-mediated degradation of cell cycle proteins	0.94	DNA Replication	0.92
Regulation of mitotic cell cycle	0.94	SCF(Skp2)-mediated degradation of p27/p21	0.86
Regulation of APC/C activators between G1/S and early anaphase	0.94	Cyclin E associated events during G1/S transition	0.86
Switching of origins to a post-replicative state	0.93	Removal of licensing factors from origins	0.86

Cellular Senescence

	Cellular Senescence	0.81			Senescence-Associated Secretory Phenotype (SASP)	0.57
	Cellular responses to stress	0.81

Find genes that share SuperPaths with CCNA1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNA1 (see all 9)

	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling
	Breast Cancer Regulation by Stathmin1
	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry

Selected GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell cycle Chromosome condensation in prometaphase
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of APC in cell cycle regulation

5 BioSystems Pathways for CCNA1

	Cell cycle
	G1 to S cell cycle control
	AMPK signaling
	Gastric cancer network 1
	C-MYB transcription factor network

Selected Reactome Pathways for CCNA1 (see all 12)

	SCF(Skp2)-mediated degradation of p27/p21
	G0 and Early G1
	Orc1 removal from chromatin
	E2F mediated regulation of DNA replication
	G1/S-Specific Transcription

Selected Kegg Pathways (Kegg details for CCNA1) (see all 8):

	Cell cycle
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Epstein-Barr virus infection
	Pathways in cancer

Pathway & Disease-focused RT² Profiler PCR Arrays including CCNA1 (see all 7):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Cytoskeleton Regulators in human mouse rat

Cell Cycle in human mouse rat

Breast Cancer in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Interactions:

GeneGlobe Interaction Network for CCNA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCNA1 (P78396^{1, 2, 3} ENSP00000255465⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 174)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MCM4	P33991²^,³, ENSP00000262105⁴	MINT-50427 I2D: score=4 STRING: ENSP00000262105
CDKN1A	P38936¹^,²^,³, ENSP00000244741⁴	EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
HIST2H3A	Q71DI3³	I2D: score=1
HIST2H3C	Q71DI3³	I2D: score=1
HIST2H3D	Q71DI3³	I2D: score=1

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Gene Ontology (GO): 10 biological process terms (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007067	mitosis	IEA	--
GO:0007141	male meiosis I	TAS	9843212
GO:0007283	spermatogenesis	TAS	9843212
GO:0010389	regulation of G2/M transition of mitotic cell cycle	IEA	--
GO:0051726	regulation of cell cycle	--	--

Find genes that share ontologies with CCNA1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CCNA1

2 Novoseek inferred chemical compound relationships for CCNA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	22.1	20	16517207 (6), 11090075 (4), 15489899 (2)
vegf	16.9	14	16007189 (7), 18612129 (5), 18534064 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts):

NM_001111045.1 NM_001111046.1 NM_001111047.1 NM_003914.3

Unigene Cluster for CCNA1:

Cyclin A1

Hs.417050 [show with all ESTs]

Unigene Representative Sequence: NM_003914

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000463403 ENST00000255465 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)

ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat CCNA1 using miScript Target Protectors
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		hsa-miR-656
		SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

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		QuantiFast Probe-based Assays in human, mouse, rat CCNA1

Additional mRNA sequence:

AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1

U97680.1

3 DOTS entries:

DT.113428 DT.75122607 DT.95165865

Selected AceView cDNA sequences (see all 68):

F13244 BC035479 CR616879 BE336946 BC036346 AI168235 BM552862 F10846

AA420962 AA421060 F10700 AA777001 CN480841 BX281383 BI825398 BE242314

BI462532 AW237229 CD171793 BG720085 BI459787 BE242234 BI770824 BP369757

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:
SP3:							-		-
SP4:							-		-
SP5:			-		-		-		-

ECgene alternative splicing isoforms for CCNA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCCACCTG

About this image

CCNA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Testis (Reproductive System)
Seminiferous Tubules

Endothelium (Cardiovascular System)
Human umbilical vein endothelial cells (HUVEC)

CCNA1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CCNA1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.417050

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell

lines

Pathway & Disease-focused RT² Profiler PCR Arrays including CCNA1 (see all 7):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Cytoskeleton Regulators in human mouse rat

Cell Cycle in human mouse rat

Breast Cancer in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CCNA1 OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CCNA1
		QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
		QuantiFast Probe-based Assays in human, mouse, rat CCNA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA1 gene from Selected species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccna1^{1 , 5}	cyclin A1^{1, 5}	83.37(n)¹ 84.32(a)¹		3 (26.52 cM)⁵ 12427¹ NM_007628.3¹ NP_031654.2¹ 55045469⁵
chicken (Gallus gallus)	Aves	CCNA1¹	cyclin A1	69.89(n) 68.73(a)		418901 XM_417097.4 XP_417097.1
lizard (Anolis carolinensis)	Reptilia	CCNA1⁶	cyclin A1	63(a)	1 ↔ 1	3(181635608-181652755)
African clawed frog (Xenopus laevis)	Amphibia	LOC397885²	Xenopus mRNA for cyclin A1	73.47(n)		X53745.1
zebrafish (Danio rerio)	Actinopterygii	ccna1¹	cyclin A1	61.03(n) 61.97(a)		404206 NM_212818.1 NP_997983.1
fruit fly (Drosophila melanogaster)	Insecta	CycA³	mitosis cyclin-dependent protein kinase, regulator	41(a)		68E1 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCA3;2¹	CYCA3;2	53.16(n) 45.83(a)		841124 NM_103614.4 NP_564499.3
rice (Oryza sativa)	Liliopsida	AK063476.1²	--	77.16(n)		AK063476.1

ENSEMBL Gene Tree for CCNA1 (if available)
TreeFam Gene Tree for CCNA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCNA1 gene

CCNE1² CCND3² CCNO² CCNB2² CCNE2² CCNB3² CCNB1² CCND1²

CCND2² CCNA2²

1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries: CCNA1_HUMAN (see all proteins):

CCNA2

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113187087^1,2	C,F	--	37003968(+)	`GGTCTG/CGATCT`	2	--	us2k¹		1		CSA	2
rs71438100^1,2	C,F	--	37003990(+)	`GATTCG/ACCTGC`	2	--	us2k¹		6		NA CSA WA EA	364
rs75649719^1,2	F	--	37004127(+)	`ACACAT/GAGATA`	2	--	us2k¹		1		WA	118
rs115606274^1,2	C,F	--	37004131(+)	`ATAGAT/CATCAG`	2	--	us2k¹		1		WA	118
rs112983504^1,2	C,F	--	37004279(+)	`AAAAAG/CATGTT`	2	--	us2k¹		2		CSA WA	120
rs147980980^1,2		--	37004595(+)	`GACAGG/TTTCCA`	4	--	us2k¹		0	--	--	--	--
rs141605253^1,2		--	37004684(+)	`AATCAA/GATGAA`	4	--	us2k¹		0	--	--	--	--
rs3814805^1,2	C	--	37004716(-)	`GCTCAC/GGAGAC`	4	--	us2k¹		10		NA EA WA	726
rs3814804^1,2	C,F	--	37004787(-)	`ACTCCG/TTCTGG`	4	--	us2k¹		1		EA	120
rs150512260^1,2		--	37004901(+)	`AAATGC/TTCCTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CCNA1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv899993	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604036 OMIM disorders: --

2 diseases for CCNA1:
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male germ cell tumor acute myeloid leukemia

1 inferred disease relationship from the University of Copenhagen DISEASES database for CCNA1:

Acute myeloid leukemia

Find genes that share disorders with CCNA1 About GenesLikeMe

Selected Novoseek inferred disease relationships for CCNA1 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	53	5	11381140 (2), 11090075 (1), 10590070 (1)
leukemia	34.3	17	19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
leukemia promyelocytic acute	27.2	3	11090075 (3)
testicular cancer	26.5	1	14510182 (1)
retinoblastoma	25	3	17455244 (3)
tumors	24.6	19	18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
wilms tumor	23.4	2	15526363 (1)
osteosarcoma	22.7	1	10757815 (1)
cancer	14.1	5	11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
lymphoblastic leukemia acute	8.84	1	16102826 (1)

Genetic Association Database (GAD): CCNA1
Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

Export disorders for CCNA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCNA1 gene, integrated from 10 sources (see all 178):
(articles sorted by number of sources associating them with CCNA1)

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Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)^{1, 2, 3, 9} Yang R.... Koeffler H.P. (Cancer Res. 1997)
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)^{1, 2, 9} Yang R.... Koeffler H.P. (Mol. Cell. Biol. 1999)
Mutations of the cyclin A1 gene are not a common cause of male infertility. (PubMed id 19886767)^{1, 4, 9} Zhoucun A....Yang Y. (Syst Biol Reprod Med 2009)
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)^{1, 4} Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)^{1, 2} Diederichs S.... Mueller-Tidow C. (J. Biol. Chem. 2004)
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)^{1, 9} Wegiel B....Persson J.L. (J. Natl. Cancer Inst. 2008)
A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)^{1, 9} Wegiel B....Persson J.L. (Oncogene 2005)
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)^{1, 9} Ji P....MA1ller-Tidow C. (Int. J. Cancer 2007)
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)^{1, 9} Liao C....Wolgemuth D.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)^{1, 9} Yang R....Koeffler H.P. (Blood 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8900	HGNC: 1577	AceView: CCNA1	Ensembl:ENSG00000133101	euGenes: HUgn8900
ECgene: CCNA1	Kegg: 8900	H-InvDB: CCNA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCNA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CCNA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCNA1 gene:
Search GeneIP for patents involving CCNA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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