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CCNA1 Gene(Protein Coding)

Cyclin A1

GCID:
GC13P036431
GIFtS:
51
Genes Participants
UDN Logo

Aliases for CCNA1 Gene

Aliases for CCNA1 Gene

  • Cyclin A1 2 3 5
  • Testicular Tissue Protein Li 34 3
  • Cyclin-A1 3
  • CT146 3

External Ids for CCNA1 Gene

Previous GeneCards Identifiers for CCNA1 Gene

  • GC13P034993
  • GC13P030993
  • GC13P035942
  • GC13P034804
  • GC13P035904
  • GC13P037005
  • GC13P017817

Summaries for CCNA1 Gene

Entrez Gene Summary for CCNA1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA1 Gene

CCNA1 (Cyclin A1) is a Protein Coding gene. Diseases associated with CCNA1 include Myeloid Leukemia and Acute Promyelocytic Leukemia. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA2.

UniProtKB/Swiss-Prot for CCNA1 Gene

  • May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Gene Wiki entry for CCNA1 Gene

Additional gene information for CCNA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNA1 Gene

Genomics for CCNA1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CCNA1 Gene

Promoters and enhancers for CCNA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13I036432 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +1.3 1271 0.6 KLF17 SIN3A BMI1 RFX5 GLIS2 EGR2 SP3 USF2 ZEB2 SREBF1 CCNA1 CCDC169 HIST1H2APS6
GH13I036431 Promoter 1 EPDnew 550.8 +0.8 767 0.1 ZNF777 ZBTB6 KLF17 MAX ZIC2 BCL11B ZNF335 ZFHX2 GLIS2 POLR2A CCNA1 HIST1H2APS6
GH13I036772 Enhancer 0.3 ENCODE 10.4 +342.0 342043 0.8 ATF7 CCNA1 LOC102723490 TCEAL4P1
GH13I036373 Enhancer 0.5 dbSUPER 4.6 -56.3 -56306 1.6 FOXA2 JUND ATF3 HNF4A ZBTB33 FOXA1 YY1 CCDC169 SPART-AS1 CCNA1 SPART
GH13I036074 Enhancer 0.5 FANTOM5 ENCODE 4 -356.1 -356088 0.7 POLR2A CCNA1 DCLK1 CCDC169 NMTRQ-TTG10-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCNA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNA1 gene promoter:

Genomic Locations for CCNA1 Gene

Genomic Locations for CCNA1 Gene
chr13:36,431,030-36,442,882
(GRCh38/hg38)
Size:
11,853 bases
Orientation:
Plus strand
chr13:37,005,967-37,017,019
(GRCh37/hg19)

Genomic View for CCNA1 Gene

Genes around CCNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCNA1 Gene

Proteins for CCNA1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78396-CCNA1_HUMAN
    Recommended name:
    Cyclin-A1
    Protein Accession:
    P78396
    Secondary Accessions:
    • B7Z7E3
    • Q5T3V0
    • Q5U0G2
    • Q8IY91

    Protein attributes for CCNA1 Gene

    Size:
    465 amino acids
    Molecular mass:
    52358 Da
    Quaternary structure:
    • Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.

    Alternative splice isoforms for CCNA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNA1 Gene

Protein Expression for CCNA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCNA1 Gene

  • Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Other Protein References for CCNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNA1 Gene

Domains & Families for CCNA1 Gene

Gene Families for CCNA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78396

UniProtKB/Swiss-Prot:

CCNA1_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA1: view

Function for CCNA1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CCNA1 Gene

GENATLAS Biochemistry:
cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell lines,regulator of cell-cycle
UniProtKB/Swiss-Prot Function:
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Gene Ontology (GO) - Molecular Function for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8756624
genes like me logo Genes that share ontologies with CCNA1: view
genes like me logo Genes that share phenotypes with CCNA1: view

Animal Models for CCNA1 Gene

MGI Knock Outs for CCNA1:

miRNA for CCNA1 Gene

miRTarBase miRNAs that target CCNA1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNA1 Gene

Localization for CCNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS 9041194
GO:0015630 microtubule cytoskeleton IDA --
GO:0097123 cyclin A1-CDK2 complex IEA --
genes like me logo Genes that share ontologies with CCNA1: view

Pathways & Interactions for CCNA1 Gene

SuperPathways for CCNA1 Gene

PathCards logo More details on SuperPathways for CCNA1
SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
Orc1 removal from chromatin
.94
Regulation of DNA replication
.94
Switching of origins to a post-replicative state
.94
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
DNA Replication
.93
Synthesis of DNA
.93
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
p53-Dependent G1 DNA Damage Response
.86
p53-Dependent G1/S DNA damage checkpoint
.86
SCF(Skp2)-mediated degradation of p27/p21
.86
Removal of licensing factors from origins
.86
G1/S DNA Damage Checkpoints
.84
S Phase
.78
2 DNA Double-Strand Break Repair
DNA Double-Strand Break Repair
.83
Homology Directed Repair
.83
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
.79
Processing of DNA double-strand break ends
.74
DNA Repair
.53
3 Cell cycle Cell cycle (generic schema)
Cell cycle Cell cycle (generic schema)
.38
Cell cycle Regulation of G1/S transition (part 2)
.38
G0 and Early G1
.31
G2 Phase
.01
4 AMP-activated Protein Kinase (AMPK) Signaling
AMPK signaling pathway
.41
AMP-activated Protein Kinase (AMPK) Signaling
.41
AMPK Signaling Pathway
.33
5 Cellular Senescence (REACTOME)
Cellular Senescence
.64
Senescence-Associated Secretory Phenotype (SASP)
.56
Cellular responses to stress
.44
genes like me logo Genes that share pathways with CCNA1: view

SIGNOR curated interactions for CCNA1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007141 male meiosis I TAS 9843212
GO:0007283 spermatogenesis TAS 9843212
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with CCNA1: view

Drugs & Compounds for CCNA1 Gene

Products:

  1. Drug

(2) Additional Compounds for CCNA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNA1: view

Transcripts for CCNA1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCNA1 Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNA1 Gene

Cyclin A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: - -
SP4: - -
SP5: - - - -

Relevant External Links for CCNA1 Gene

GeneLoc Exon Structure for
CCNA1
ECgene alternative splicing isoforms for
CCNA1

Expression for CCNA1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNA1 Gene

mRNA expression in normal human tissues for CCNA1 Gene
mRNA expression by BioGPS for CCNA1 GenemRNA expression by GTEx for CCNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNA1 Gene

This gene is overexpressed in Testis (x15.6) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CCNA1 Gene

This gene is overexpressed in Heart (35.9) and Testis (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNA1 Gene



Protein tissue co-expression partners for CCNA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNA1 Gene:

CCNA1

SOURCE GeneReport for Unigene cluster for CCNA1 Gene:

Hs.417050

mRNA Expression by UniProt/SwissProt for CCNA1 Gene:

P78396-CCNA1_HUMAN
Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Evidence on tissue expression from TISSUES for CCNA1 Gene

  • Nervous system(4.4)
  • Blood(4.3)
  • Lymph node(4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with CCNA1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNA1 Gene

Orthologs for CCNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCNA1 33 34
  • 99.68 (n)
dog
(Canis familiaris)
 Mammalia CCNA1 33 34
  • 88.6 (n)
cow
(Bos Taurus)
 Mammalia CCNA1 33 34
  • 86.54 (n)
rat
(Rattus norvegicus)
 Mammalia Ccna1 33
  • 83.53 (n)
mouse
(Mus musculus)
 Mammalia Ccna1 33 16 34
  • 83.37 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCNA1 34
  • 83 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CCNA1 34
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCNA1 33 34
  • 69.89 (n)
lizard
(Anolis carolinensis)
 Reptilia CCNA1 34
  • 63 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccna1 33
  • 66.75 (n)
Str.4034 33
African clawed frog
(Xenopus laevis)
 Amphibia LOC397885 33
zebrafish
(Danio rerio)
 Actinopterygii ccna1 33 34
  • 61.03 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2245 33
fruit fly
(Drosophila melanogaster)
 Insecta CycA 35 34
  • 41 (a)
worm
(Caenorhabditis elegans)
 Secernentea ZK507.6 35
  • 36 (a)
thale cress
(Arabidopsis thaliana)
 eudicotyledons CYCA3;2 33
  • 53.16 (n)
rice
(Oryza sativa)
 Liliopsida Os03g0607600 33
  • 51.75 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10122 34
  • 57 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.5837 33
Species where no ortholog for CCNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNA1 Gene

ENSEMBL:
Gene Tree for CCNA1 (if available)
TreeFam:
Gene Tree for CCNA1 (if available)

Paralogs for CCNA1 Gene

Paralogs for CCNA1 Gene

(1) SIMAP similar genes for CCNA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCNA1: view

Variants for CCNA1 Gene

Sequence variations from dbSNP and Humsavar for CCNA1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000039439 -- 36,436,998(+) T/A intron_variant
rs1000557771 -- 36,436,774(+) C/T intron_variant
rs1000618259 -- 36,433,309(+) T/C intron_variant
rs1000820410 -- 36,431,378(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000968174 -- 36,437,265(+) A/G intron_variant

Variation tolerance for CCNA1 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNA1 Gene

Disorders for CCNA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCNA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
acute promyelocytic leukemia
  • apl
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search CCNA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNA1 Gene

Publications for CCNA1 Gene

  1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PMID: 9041194) Yang R … Koeffler HP (Cancer research 1997) 2 3 4 22 58
  2. Mutations of the cyclin A1 gene are not a common cause of male infertility. (PMID: 19886767) Zhoucun A … Yang Y (Systems biology in reproductive medicine 2009) 3 22 44 58
  3. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PMID: 10022926) Yang R … Koeffler HP (Molecular and cellular biology 1999) 3 4 22 58
  4. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PMID: 20457893) Hsia DA … Izumiya Y (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22 58
  5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 44 58

Products for CCNA1 Gene

Sources for CCNA1 Gene

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