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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNA1 Gene

protein-coding   GIFtS: 66
GCID: GC13P037005

Cyclin A1
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Aliases
for CCNA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cyclin A11 2
cyclin-A12

External Ids:    HGNC: 15771   Entrez Gene: 89002   Ensembl: ENSG000001331017   OMIM: 6040365   UniProtKB: P783963   

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817


Summaries
for CCNA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCNA1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and
brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the
germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase
activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This
cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor
E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA1 Gene: 
CCNA1 (cyclin A1) is a protein-coding gene. Diseases associated with CCNA1 include polyploidy, and testicular cancer, and among its related super-pathways are Cell cycle Role of SCF complex in cell cycle regulation and Mitotic G1-G1/S phases. GO annotations related to this gene include protein binding and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
cell cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1) Gene


Genomic Views
for CCNA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNA1 gene promoter:
         MyoD   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037005:  view genomic region     (about GC identifiers)

Start:
 37,005,967 bp from pter      End:
 37,017,019 bp from pter
Size:
 11,053 bases      Orientation:
 plus strand

Proteins
for CCNA1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)
Recommended Name: Cyclin-A1  
Size: 465 amino acids; 52358 Da
Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme
complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro).
The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with
CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9
Subcellular location: Nucleus (By similarity)
Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M
phases
Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91
Alternative splicing: 3 isoforms:  P78396-1   P78396-2   P78396-3   

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Explore proteomics data for CCNA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its
    degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78396

    • CCNA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNA1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001104515.1  NP_001104516.1  NP_001104517.1  NP_003905.1  

    ENSEMBL proteins: 
     ENSP00000255465   ENSP00000396479   ENSP00000400666   ENSP00000409873  
    Reactome Protein details: P78396
    Human Recombinant Protein Products for CCNA1: 
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    OriGene MassSpec for CCNA1 
    OriGene Custom Protein Services for CCNA1
    GenScript Custom Purified and Recombinant Proteins Services for CCNA1
    Novus Biologicals CCNA1 Protein
    Novus Biologicals CCNA1 Lysate
    Sino Biological Recombinant Protein for CCNA1
    Sino Biological Cell Lysate for CCNA1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNA1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS9041194
    GO:0015630microtubule cytoskeleton IDA--

    CCNA1 for ontologies           About GeneDecksing



    CCNA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
    R&D Systems Antibodies for CCNA1 (Cyclin A1)
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    OriGene Custom Antibody Services for CCNA1
    GenScript Custom Superior Antibodies Services for CCNA1
    Novus Biologicals CCNA1 Antibodies
    Abcam antibodies for CCNA1
    Cloud-Clone Corp. Antibodies for CCNA1 
    ThermoFisher Antibody for CCNA1
    LSBio Antibodies in human, mouse, rat for CCNA1 

    Assay Products for CCNA1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNA1 
    Cloud-Clone Corp. CLIAs for CCNA1

    Protein Domains /
    Families
    for CCNA1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P78396

    ProtoNet protein and cluster: P78396

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    CCNA1 for domains           About GeneDecksing


    Function
    for CCNA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNA1_HUMAN, P78396
    Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May
    primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic
    cell cycle in some somatic cells

         Genatlas biochemistry entry for CCNA1:
    cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell
    lines,regulator of cell-cycle

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0019901protein kinase binding IEA--
         
    CCNA1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccna1):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     reproductive system 

    CCNA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccna1tm1Djw for CCNA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNA1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
    OriGene RNAi products in human, mouse, rat for CCNA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCNA1
    Sirion Biotech Customized adenovirus for overexpression of CCNA1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCNA1 (see all 20)
    OriGene ORF clones in mouse, rat for CCNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
    Sino Biological Human cDNA Clone for CCNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1
    Sirion Biotech Customized lentivirus for stable overexpression of CCNA1 
                         Customized lentivirus expression plasmids for stable overexpression of CCNA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCNA1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1


    Pathways & Interactions
    for CCNA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNA1 About   (see all 32)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle Cell cycle (generic schema)
    		Cell cycle Regulation of G1/S transition (part 1)0.39
    		Cell cycle ESR1 regulation of G1/S transition0.33
    		Cell cycle Cell cycle (generic schema)0.38
    		G0 and Early G10.31
    		Cell cycle Regulation of G1/S transition (part 2)0.38
    2Mitotic G1-G1/S phases
    		Mitotic G1-G1/S phases0.80
    		G1 to S cell cycle control0.36
    		G1/S Transition0.80
    3Cell cycle Transition and termination of DNA replacation
    		Cell cycle Transition and termination of DNA replication0.95
    		Cell cycle Transition and termination of DNA replacation0.95
    4Cell cycle
    		Cell cycle0.59
    		Cell cycle0.59
    5CDK-mediated phosphorylation and removal of Cdc6
    		Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    		Cyclin E associated events during G1/S transition 0.89
    		Regulation of APC/C activators between G1/S and early anaphase0.94
    		Orc1 removal from chromatin0.89
    		APC/C-mediated degradation of cell cycle proteins0.94
    		Switching of origins to a post-replicative state0.89
    		Regulation of mitotic cell cycle0.94
    		Cyclin A:Cdk2-associated events at S phase entry0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for CCNA1 (see all 10)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA1 (see all 9)
        Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling
    Breast Cancer Regulation by Stathmin1
    G1-S Phase Transition
    Estrogen-mediated S-Phase Entry

    5/9 GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cell cycle Chromosome condensation in prometaphase
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of APC in cell cycle regulation

    5 BioSystems Pathways for CCNA1
        Cell cycle
    G1 to S cell cycle control
    AMPK signaling
    Gastric cancer network 1
    C-MYB transcription factor network


    5/26        Reactome Pathways for CCNA1 (see all 26)
        SCF(Skp2)-mediated degradation of p27/p21
    Mitotic G1-G1/S phases
    DNA Replication
    G0 and Early G1
    Removal of licensing factors from origins


    5/8         Kegg Pathways  (Kegg details for CCNA1) (see all 8):
        Cell cycle
    Progesterone-mediated oocyte maturation
    Hepatitis B
    Epstein-Barr virus infection
    Pathways in cancer


    CCNA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for CCNA1 (P783961, 2, 3 ENSP000002554654) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    MCM4P339912, 3, ENSP000002621054MINT-50427 I2D: score=4 STRING: ENSP00000262105
    About this table

    Gene Ontology (GO): 10 biological process terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007141male meiosis I TAS9843212
    GO:0007283spermatogenesis TAS9843212
    GO:0051301cell division IEA--
    GO:0051726regulation of cell cycle ----

    CCNA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNA1

    2 Novoseek inferred chemical compound relationships for CCNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 22.1 20 16517207 (6), 11090075 (4), 15489899 (2)
    vegf 16.9 14 16007189 (7), 18612129 (5), 18534064 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNA1

    Transcripts
    for CCNA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts): 
    NM_001111045.1  NM_001111046.1  NM_001111047.1  NM_003914.3  

    Unigene Cluster for CCNA1:

    Cyclin A1
    Hs.417050  [show with all ESTs]
    Unigene Representative Sequence: NM_003914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463403 ENST00000255465 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)
    ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA1

    Additional mRNA sequence: 

    AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1 
    U97680.1 

    3 DOTS entries:

    DT.113428  DT.75122607  DT.95165865 

    24/68 AceView cDNA sequences (see all 68):

    BC035479 AI168235 AA420962 CR616879 F10700 BM552862 AA421060 BC036346 
    BX281383 BE336946 F10846 F13244 CN480841 AA777001 BI770520 BI560831 
    AA758807 AW590053 BP369757 AI637969 F13099 CD617690 AA758620 AW237229 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                    -     -                                                                     
    SP4:                    -     -                                                                     
    SP5:        -     -     -     -                                                                     


    ECgene alternative splicing isoforms for CCNA1

    Expression
    for CCNA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNA1 expression in normal human tissues (normalized intensities)      CCNA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCACCTG
    CCNA1 Expression
    About this image


    CCNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Human umbilical vein endothelial cells (HUVEC)
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Lymphatic Fibroblasts (HLF)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Smooth Muscle (Muscoskeletal System)
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   

    See CCNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNA1

    SOURCE GeneReport for Unigene cluster: Hs.417050

    UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
    Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell
    lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNA1 (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    Orthologs
    for CCNA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNA1 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ccna11 , 5 cyclin A11, 5 83.37(n)1
    84.32(a)1    		   3 (26.52 cM)5
    124271  NM_007628.31  NP_031654.21 
     550454695 
    chicken
    (Gallus gallus)    		 Aves CCNA11 cyclin A1 69.9(n)
    68.91(a)    		   418901  XM_417097.3  XP_417097.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCNA16
    		 Uncharacterized protein
    		 62(a)
    		 1 ↔ 1
    		 3(181635608-181652755)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3978852 Xenopus mRNA for cyclin A1 73.47(n)    X53745.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ccna11 cyclin A1 61.06(n)
    61.9(a)    		   404206  NM_212818.1  NP_997983.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CycA3 mitosis cyclin-dependent protein
    kinase, regulator    		 41(a)   68E1   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CLB66
    CLB36
    (see all 6)    		 B-type cyclin involved in DNA replication during S...
    B-type cyclin involved in cell cycle progression; ...
    (see all 6)    		 23(a)
    20(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 VII(705359-706501)
    IV(176773-178056)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYCA3;21 cyclin-A3-2 53.16(n)
    45.83(a)    		   841124  NM_103614.4  NP_564499.3 
    rice
    (Oryza sativa)    		 Liliopsida AK063476.12   -- 77.16(n)    AK063476.1 


    ENSEMBL Gene Tree for CCNA1 (if available)
    TreeFam Gene Tree for CCNA1 (if available)

    Paralogs
    for CCNA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNA1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCND22  CCNA22  
    1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries:     CCNA1_HUMAN (see all proteins):
    CCNA2

    CCNA1 for paralogs           About GeneDecksing



    Genomic Variants
    for CCNA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/325 SNPs in CCNA1 are shown (see all 325)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1131870871,2
    		C,F--37003968(+) GGTCTG/CGATCT 2 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs714381001,2
    		C,F--37003990(+) GATTCG/ACCTGC 2 -- us2k16Minor allele frequency- A:0.21NA CSA WA EA 364
    rs756497191,2
    		F--37004127(+) ACACAT/GAGATA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1156062741,2
    		C,F--37004131(+) ATAGAT/CATCAG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1129835041,2
    		C,F--37004279(+) AAAAAG/CATGTT 2 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1479809801,2
    		--37004595(+) GACAGG/TTTCCA 4 -- us2k10--------
    rs1416052531,2
    		--37004684(+) AATCAA/GATGAA 4 -- us2k10--------
    rs38148051,2
    		C--37004716(-) GCTCAC/GGAGAC 4 -- us2k110Minor allele frequency- G:0.14NA EA WA 726
    rs38148041,2
    		C,F--37004787(-) ACTCCG/TTCTGG 4 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1505122601,2
    		--37004901(+) AAATGC/TTCCTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899993CNV Gain21882294

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    Disorders / Diseases
    for CCNA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 604036    OMIM disorders: --

    20/37 diseases for CCNA1 (see all 37):    About MalaCards
    polyploidy    testicular cancer    acute promyelocytic leukemia    cervical intraepithelial neoplasia
    laryngeal squamous cell carcinoma    male infertility    wilms tumor    osteosarcoma
    germ cell tumors    chronic myeloid leukemia    retinoblastoma    acute myeloid leukemia
    lymphoblastic leukemia    myeloid leukemia    azoospermia    oral cancer
    infertility    myelodysplastic syndromes    laryngitis    acute leukemia

    1 disease from the University of Copenhagen DISEASES database for CCNA1:
    Acute myeloid leukemia

    CCNA1 for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for CCNA1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 53 5 11381140 (2), 11090075 (1), 10590070 (1)
    leukemia 34.3 17 19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
    leukemia promyelocytic acute 27.2 3 11090075 (3)
    testicular cancer 26.5 1 14510182 (1)
    retinoblastoma 25 3 17455244 (3)
    tumors 24.6 19 18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
    wilms tumor 23.4 2 15526363 (1)
    osteosarcoma 22.7 1 10757815 (1)
    cancer 14.1 5 11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
    lymphoblastic leukemia acute 8.84 1 16102826 (1)

    Genetic Association Database (GAD): CCNA1
    Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

    Export disorders for CCNA1 gene to outside databases

    Publications
    for CCNA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNA1 gene, integrated from 9 sources (see all 175):
    (articles sorted by number of sources associating them with CCNA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)1, 2, 3, 9 Yang R.... Koeffler H.P. (1997)
    2. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)1, 2, 9 Yang R.... Koeffler H.P. (1999)
    3. Mutations of the cyclin A1 gene are not a common caus e of male infertility. (PubMed id 19886767)1, 4, 9 Zhoucun A....Yang Y. (2009)
    4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    5. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)1, 2 Diederichs S.... Mueller-Tidow C. (2004)
    6. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)1, 9 Wegiel B....Persson J.L. (2008)
    7. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)1, 9 Wegiel B....Persson J.L. (2005)
    8. DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)1, 9 Ji P....Muller-Tidow C. (2007)
    9. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)1, 9 Liao C....Wolgemuth D.J. (2001)
    10. Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)1, 9 Yang R....Koeffler H.P. (1999)

    External Searches for CCNA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8900 HGNC: 1577 AceView: CCNA1 Ensembl:ENSG00000133101 euGenes: HUgn8900
    ECgene: CCNA1 Kegg: 8900 H-InvDB: CCNA1

    Other Databases showing CCNA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CCNA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNA1 gene:
    Search GeneIP for patents involving CCNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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