Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNA1 Gene

protein-coding GIFtS: 66
GCID: GC13P037005

Cyclin A1

Microbiology & Infectious Diseases Congress

37 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Cyclin A1¹ ²
cyclin-A1²

External Ids:	HGNC: 1577¹	Entrez Gene: 8900²	Ensembl: ENSG00000133101⁷	OMIM: 604036⁵	UniProtKB: P78396³

Export aliases for CCNA1 gene to outside databases

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804 GC13P035904 GC13P017817

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNA1 Gene:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in

several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle.

This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the

other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle

regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA1 Gene:

CCNA1 (cyclin A1) is a protein-coding gene. Diseases associated with CCNA1 include polyploidy, and testicular cancer, and among its related super-pathways are Cell cycle Role of SCF complex in cell cycle regulation and Mitotic G1-G1/S phases. GO annotations related to this gene include protein binding and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell

cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NT_024524.14 NC_018924.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNA1 gene promoter:
MyoD IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNA1 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3-q13 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P037005: view genomic region (about GC identifiers)

Start:	37,005,967 bp from pter	End:	37,017,019 bp from pter
Size:	11,053 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)

Recommended Name: Cyclin-A1

Size: 465 amino acids; 52358 Da

Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The

cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin

A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and

CCNE1 (By similarity). Interacts with INCA1 and KLHDC9

Subcellular location: Nucleus (By similarity)

Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases

Secondary accessions: B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91

Alternative splicing: 3 isoforms: P78396-1 P78396-2 P78396-3

Explore the universe of human proteins at neXtProt for CCNA1: NX_P78396

Explore proteomics data for CCNA1 at MOPED

Post-translational modifications:

UniProtKB: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation

by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P78396

CCNA1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001104515.1 NP_001104516.1 NP_001104517.1 NP_003905.1

ENSEMBL proteins:

ENSP00000255465 ENSP00000396479 ENSP00000400666 ENSP00000409873

Reactome Protein details: P78396
Human Recombinant Protein Products for CCNA1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CCNA1 OriGene Protein Over-expression Lysate for CCNA1 OriGene MassSpec for CCNA1 OriGene Custom Protein Services for CCNA1
	GenScript Custom Purified and Recombinant Proteins Services for CCNA1
	Novus Biologicals CCNA1 Protein Novus Biologicals CCNA1 Lysate
	Sino Biological Recombinant Protein for CCNA1 Sino Biological Cell Lysate for CCNA1
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CCNA1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	9041194
GO:0015630	microtubule cytoskeleton	IDA	--

CCNA1 for ontologies About GeneDecksing

CCNA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
	R&D Systems Antibodies for CCNA1 (Cyclin A1)
	OriGene Antibodies for CCNA1 OriGene Custom Antibody Services for CCNA1
	GenScript Custom Superior Antibodies Services for CCNA1
	Novus Biologicals CCNA1 Antibodies
	Abcam antibodies for CCNA1
	Cloud-Clone Corp. Antibodies for CCNA1
	ThermoFisher Antibody for CCNA1
	LSBio Antibodies in human, mouse, rat for CCNA1

Assay Products for CCNA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCNA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNA1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CCNA1 Cloud-Clone Corp. CLIAs for CCNA1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C-dom

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P78396

ProtoNet protein and cluster: P78396

1 Blocks protein domain: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

CCNA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May

primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell

cycle in some somatic cells

Genatlas biochemistry entry for CCNA1:

cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell

lines,regulator of cell-cycle

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15232106
GO:0019901	protein kinase binding	IEA	--

CCNA1 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccna1):

cellular	endocrine/exocrine gland	hematopoietic system	immune system	mortality/aging
reproductive system

CCNA1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ccna1^tm1Djw for CCNA1

inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNA1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNA1

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
		hsa-miR-656
		SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
		OriGene RNAi products in human, mouse, rat for CCNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCNA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CCNA1
			Sirion Biotech Customized adenovirus for overexpression of CCNA1 Customized adenovirus for potent knockdown of CCNA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CCNA1 (see all 20) OriGene ORF clones in mouse, rat for CCNA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
		Sino Biological Human cDNA Clone for CCNA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNA1
		Search LifeMap BioReagents cell lines for CCNA1
		Sirion Biotech Customized stable knockdown cell line services for CCNA1 Customized inducible knockdown cell line services for CCNA1 Customized stable overexpressing cell line services for CCNA1 Customized inducible overexpressing cell line services for CCNA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CCNA1 About (see all 32)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Cell cycle Cell cycle (generic schema)

Cell cycle Regulation of G1/S transition (part 1)	0.39	Cell cycle ESR1 regulation of G1/S transition	0.33
Cell cycle Cell cycle (generic schema)	0.38	G0 and Early G1	0.31
Cell cycle Regulation of G1/S transition (part 2)	0.38

Mitotic G1-G1/S phases

	Mitotic G1-G1/S phases	0.80			G1 to S cell cycle control	0.36
	G1/S Transition	0.80

Cell cycle Transition and termination of DNA replacation

Cell cycle Transition and termination of DNA replication

0.95

Cell cycle Transition and termination of DNA replacation

0.95

Cell cycle

Cell cycle

0.59

Cell cycle

0.59

CDK-mediated phosphorylation and removal of Cdc6

Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.94	Cyclin E associated events during G1/S transition	0.89
Regulation of APC/C activators between G1/S and early anaphase	0.94	Orc1 removal from chromatin	0.89
APC/C-mediated degradation of cell cycle proteins	0.94	Switching of origins to a post-replicative state	0.89
Regulation of mitotic cell cycle	0.94	Cyclin A:Cdk2-associated events at S phase entry	0.88

Pathways by source See SuperPaths
Show all pathways

5/10 EMD Millipore Pathways for CCNA1 (see all 10)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA1 (see all 9)

	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling
	Breast Cancer Regulation by Stathmin1
	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry

5/9 GeneGo (Thomson Reuters) Pathways for CCNA1 (see all 9)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell cycle Chromosome condensation in prometaphase
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of APC in cell cycle regulation

5 BioSystems Pathways for CCNA1

	Cell cycle
	G1 to S cell cycle control
	AMPK signaling
	Gastric cancer network 1
	C-MYB transcription factor network

5/26 Reactome Pathways for CCNA1 (see all 26)

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	DNA Replication
	G0 and Early G1
	Removal of licensing factors from origins

5/8 Kegg Pathways (Kegg details for CCNA1) (see all 8):

	Cell cycle
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Epstein-Barr virus infection
	Pathways in cancer

CCNA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/119 Interacting proteins for CCNA1 (P78396^{1, 2, 3} ENSP00000255465⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 119)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1A	P38936¹^,²^,³, ENSP00000244741⁴	EBI-375065,EBI-375077 MINT-50429 I2D: score=4 STRING: ENSP00000244741
HIST2H3A	Q71DI3³	I2D: score=1
HIST2H3C	Q71DI3³	I2D: score=1
HIST2H3D	Q71DI3³	I2D: score=1
MCM4	P33991²^,³, ENSP00000262105⁴	MINT-50427 I2D: score=4 STRING: ENSP00000262105

About this table

Gene Ontology (GO): 10 biological process terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007067	mitosis	IEA	--
GO:0007141	male meiosis I	TAS	9843212
GO:0007283	spermatogenesis	TAS	9843212
GO:0051301	cell division	IEA	--
GO:0051726	regulation of cell cycle	--	--

CCNA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNA1

2 Novoseek inferred chemical compound relationships for CCNA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	22.1	20	16517207 (6), 11090075 (4), 15489899 (2)
vegf	16.9	14	16007189 (7), 18612129 (5), 18534064 (1)

Search CenterWatch for drugs/clinical trials and news about CCNA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts):

NM_001111045.1 NM_001111046.1 NM_001111047.1 NM_003914.3

Unigene Cluster for CCNA1:

Cyclin A1

Hs.417050 [show with all ESTs]

Unigene Representative Sequence: NM_003914

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000463403 ENST00000255465 ENST00000418263(uc001uvs.4 uc001uvr.4 uc010abr.3)

ENST00000440264(uc010teo.2 uc010abp.3) ENST00000449823(uc010abq.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCNA1:
		hsa-miR-656
		SwitchGear 3'UTR luciferase reporter plasmid: CCNA1 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
		OriGene RNAi products in human, mouse, rat for CCNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CCNA1

Clone Products:		OriGene clones in human, mouse for CCNA1 (see all 20) OriGene ORF clones in mouse, rat for CCNA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCNA1 (NM_003914)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

Primer Products:		OriGene qPCR primer pairs and template standards for CCNA1 OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA1

Additional mRNA sequence:

AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 U66838.1

U97680.1

3 DOTS entries:

DT.113428 DT.75122607 DT.95165865

24/68 AceView cDNA sequences (see all 68):

BC035479 AI168235 AA420962 CR616879 F10700 BM552862 AA421060 BC036346

BX281383 BE336946 F10846 F13244 CN480841 AA777001 BI770520 BI560831

AA758807 AW590053 BP369757 AI637969 F13099 CD617690 AA758620 AW237229

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:
SP3:							-		-
SP4:							-		-
SP5:			-		-		-		-

ECgene alternative splicing isoforms for CCNA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNA1 expression in normal human tissues (normalized intensities) CCNA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCCACCTG

About this image

CCNA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Umbilical Cord (Extraembryonic Tissues)
Human umbilical vein endothelial cells (HUVEC)

Endothelium (Cardiovascular System)
Human umbilical vein endothelial cells (HUVEC)

Bone (Muscoskeletal System)
BONE MARROW

Inner Cell Mass (Early Embryo)
CyT49

Blood (Cardiovascular System)
BONE MARROW

See CCNA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNA1

SOURCE GeneReport for Unigene cluster: Hs.417050

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNA1 (see all 7):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Cytoskeleton Regulators in human mouse rat

Cell Cycle in human mouse rat

Breast Cancer in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CCNA1 OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA1 gene from 9/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccna1^{1 , 5}	cyclin A1^{1, 5}	83.37(n)¹ 84.32(a)¹		3 (26.52 cM)⁵ 12427¹ NM_007628.3¹ NP_031654.2¹ 55045469⁵
chicken (Gallus gallus)	Aves	CCNA1¹	cyclin A1	69.9(n) 68.91(a)		418901 XM_417097.3 XP_417097.1
lizard (Anolis carolinensis)	Reptilia	CCNA1⁶	Uncharacterized protein	62(a)	1 ↔ 1	3(181635608-181652755)
African clawed frog (Xenopus laevis)	Amphibia	LOC397885²	Xenopus mRNA for cyclin A1	73.47(n)		X53745.1
zebrafish (Danio rerio)	Actinopterygii	ccna1¹	cyclin A1	61.06(n) 61.9(a)		404206 NM_212818.1 NP_997983.1
fruit fly (Drosophila melanogaster)	Insecta	CycA³	mitosis cyclin-dependent protein kinase, regulator	41(a)		68E1 --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CLB6⁶ CLB3⁶ (see all 6)	B-type cyclin involved in DNA replication during S... B-type cyclin involved in cell cycle progression; ... (see all 6)	23(a) 20(a) (see all 6)	many ↔ many many ↔ many (see all 6)	VII(705359-706501) IV(176773-178056)
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCA3;2¹	cyclin-A3-2	53.16(n) 45.83(a)		841124 NM_103614.4 NP_564499.3
rice (Oryza sativa)	Liliopsida	AK063476.1²	--	77.16(n)		AK063476.1

ENSEMBL Gene Tree for CCNA1 (if available)
TreeFam Gene Tree for CCNA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNA1 gene

CCNE1² CCND3² CCNO² CCNB2² CCNE2² CCNB3² CCNB1² CCND1²

CCND2² CCNA2²

1 SIMAP similar gene for CCNA1 using alignment to 2 protein entries: CCNA1_HUMAN (see all proteins):

CCNA2

CCNA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113187087^1,2	C,F	--	37003968(+)	`GGTCTG/CGATCT`	2	--	us2k¹		1		CSA	2
rs71438100^1,2	C,F	--	37003990(+)	`GATTCG/ACCTGC`	2	--	us2k¹		6		NA CSA WA EA	364
rs75649719^1,2	F	--	37004127(+)	`ACACAT/GAGATA`	2	--	us2k¹		1		WA	118
rs115606274^1,2	C,F	--	37004131(+)	`ATAGAT/CATCAG`	2	--	us2k¹		1		WA	118
rs112983504^1,2	C,F	--	37004279(+)	`AAAAAG/CATGTT`	2	--	us2k¹		2		CSA WA	120
rs147980980^1,2		--	37004595(+)	`GACAGG/TTTCCA`	4	--	us2k¹		0	--	--	--	--
rs141605253^1,2		--	37004684(+)	`AATCAA/GATGAA`	4	--	us2k¹		0	--	--	--	--
rs3814805^1,2	C	--	37004716(-)	`GCTCAC/GGAGAC`	4	--	us2k¹		10		NA EA WA	726
rs3814804^1,2	C,F	--	37004787(-)	`ACTCCG/TTCTGG`	4	--	us2k¹		1		EA	120
rs150512260^1,2		--	37004901(+)	`AAATGC/TTCCTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNA1 (37005967 - 37017019 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CCNA1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv899993	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNA1

DNA2.0 Custom Variant and Variant Library Synthesis for CCNA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNA1 for disorders           About GeneDecksing

OMIM gene information: 604036    OMIM disorders: --

20/37 diseases for CCNA1 (see all 37):    About MalaCards

polyploidy testicular cancer acute promyelocytic leukemia cervical intraepithelial neoplasia

laryngeal squamous cell carcinoma male infertility wilms tumor osteosarcoma

germ cell tumors chronic myeloid leukemia retinoblastoma acute myeloid leukemia

lymphoblastic leukemia myeloid leukemia azoospermia oral cancer

infertility myelodysplastic syndromes laryngitis acute leukemia

1 disease from the University of Copenhagen DISEASES database for CCNA1:

Acute myeloid leukemia

10/13 Novoseek inferred disease relationships for CCNA1 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	53	5	11381140 (2), 11090075 (1), 10590070 (1)
leukemia	34.3	17	19668232 (4), 10068680 (3), 18559500 (2), 17455244 (2) (see all 7)
leukemia promyelocytic acute	27.2	3	11090075 (3)
testicular cancer	26.5	1	14510182 (1)
retinoblastoma	25	3	17455244 (3)
tumors	24.6	19	18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
wilms tumor	23.4	2	15526363 (1)
osteosarcoma	22.7	1	10757815 (1)
cancer	14.1	5	11212263 (1), 19582787 (1), 16524460 (1), 20457893 (1)
lymphoblastic leukemia acute	8.84	1	16102826 (1)

Genetic Association Database (GAD): CCNA1
Human Genome Epidemiology (HuGE) Navigator: CCNA1 (3 documents)

Export disorders for CCNA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNA1 gene, integrated from 9 sources (see all 175):
(articles sorted by number of sources associating them with CCNA1)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)^{1, 2, 3, 9} Yang R.... Koeffler H.P. (1997)
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)^{1, 2, 9} Yang R.... Koeffler H.P. (1999)
Mutations of the cyclin A1 gene are not a common caus e of male infertility. (PubMed id 19886767)^{1, 4, 9} Zhoucun A....Yang Y. (2009)
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)^{1, 4} Cunningham J.M....Fridley B.L. (2009)
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)^{1, 2} Diederichs S.... Mueller-Tidow C. (2004)
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)^{1, 9} Wegiel B....Persson J.L. (2008)
A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)^{1, 9} Wegiel B....Persson J.L. (2005)
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)^{1, 9} Ji P....Muller-Tidow C. (2007)
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)^{1, 9} Liao C....Wolgemuth D.J. (2001)
Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)^{1, 9} Yang R....Koeffler H.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8900	HGNC: 1577	AceView: CCNA1	Ensembl:ENSG00000133101	euGenes: HUgn8900
ECgene: CCNA1	Kegg: 8900	H-InvDB: CCNA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CCNA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCNA1 gene:
Search GeneIP for patents involving CCNA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CCNA1 (Cyclin A1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for CCNA1		OriGene RNAi products in human, mouse, rat for CCNA1
	OriGene qPCR primer pairs and template standards for CCNA1		OriGene Protein Over-expression Lysate for CCNA1
	OriGene MassSpec something-or-other for CCNA1		OriGene clones in human, mouse for CCNA1
	OriGene qSTAR qPCR primer pairs in human, mouse for CCNA1		OriGene Purified Protein for CCNA1
	OriGene ORF clones in mouse, rat for CCNA1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CCNA1		OriGene Custom Protein Services for CCNA1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNA1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA1

	GenScript Custom Purified and Recombinant Proteins Services for CCNA1		GenScript cDNA clones with any tag delivered in your preferred vector for CCNA1
	GenScript Custom Assay Services for CCNA1		GenScript Custom Superior Antibodies Services for CCNA1
	GenScript Custom overexpressing Cell Line Services for CCNA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CCNA1 promoter
	Search Chromatin IP Primers for CCNA1
	RT² qPCR Primer Assay in human, mouse, rat CCNA1
	GNC Network for CCNA1
	SABiosciences PCR Arrays including human, mouse, rat CCNA1

Search Tocris compounds for CCNA1

	Proteins and Antibodies for CCNA1
	Cell Lysates for CCNA1
	cDNA Clones for CCNA1
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CCNA1 antibodies
	CCNA1 proteins
	CCNA1 lysates

	Antibodies for CCNA1
	See all of Abcam's Antibodies, Kits and Proteins for CCNA1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for CCNA1
	Antibodies for CCNA1
	ELISAs for CCNA1
	CLIAs for CCNA1

Search LifeMap BioReagents cell lines for CCNA1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA1

	SwitchGear 3'UTR luciferase reporter plasmids for CCNA1
	SwitchGear Promoter luciferase reporter plasmids for CCNA1

ThermoFisher Antibody for CCNA1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNA1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNA1

Customized:

	stable knockdown cell line services for CCNA1
	inducible knockdown cell line services for CCNA1
	design and validation of potent shRNA sequences against CCNA1
	adenovirus for potent knockdown of CCNA1
	stable overexpressing cell line services for CCNA1
	inducible overexpressing cell line services for CCNA1
	adenovirus for overexpression of CCNA1

LSBio Antibodies in human, mouse, rat for CCNA1

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCNA1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CCNA1 Gene

Cyclin A1

Aliases
for CCNA1 gene

Summaries
for CCNA1 gene

Genomic Views
for CCNA1 gene

Proteins
for CCNA1 gene

Protein Domains /
Families
for CCNA1 gene

Function
for CCNA1 gene

Pathways & Interactions
for CCNA1 gene

Drugs & Compounds
for CCNA1 gene

Transcripts
for CCNA1 gene

Expression
for CCNA1 gene

Orthologs
for CCNA1 gene

Paralogs
for CCNA1 gene

Genomic Variants
for CCNA1 gene

Disorders / Diseases
for CCNA1 gene

Publications
for CCNA1 gene

External Searches for CCNA1 gene

Genome Databases showing CCNA1 gene

Other Databases showing CCNA1 gene

Specialized Databases showing CCNA1 gene

Intellectual Property
for CCNA1 gene

Products
for CCNA1 gene

View Random Gene

Advanced Search

Export list of displayed genes

CCNA1 Gene

Cyclin A1

Aliasesfor CCNA1 gene

Summariesfor CCNA1 gene

Genomic Viewsfor CCNA1 gene

Proteinsfor CCNA1 gene

Protein Domains /Familiesfor CCNA1 gene

Functionfor CCNA1 gene

Pathways & Interactionsfor CCNA1 gene

Drugs & Compoundsfor CCNA1 gene

Transcriptsfor CCNA1 gene

Expression for CCNA1 gene

Orthologsfor CCNA1 gene

Paralogsfor CCNA1 gene

Genomic Variantsfor CCNA1 gene

Disorders / Diseasesfor CCNA1 gene

Publicationsfor CCNA1 gene

External Searches for CCNA1 gene

Genome Databases showing CCNA1 gene

Other Databases showing CCNA1 gene

Specialized Databases showing CCNA1 gene

Intellectual Propertyfor CCNA1 gene

Productsfor CCNA1 gene

View Random Gene

Aliases
for CCNA1 gene

Summaries
for CCNA1 gene

Genomic Views
for CCNA1 gene

Proteins
for CCNA1 gene

Protein Domains /
Families
for CCNA1 gene

Function
for CCNA1 gene

Pathways & Interactions
for CCNA1 gene

Drugs & Compounds
for CCNA1 gene

Transcripts
for CCNA1 gene

Expression
for CCNA1 gene

Orthologs
for CCNA1 gene

Paralogs
for CCNA1 gene

Genomic Variants
for CCNA1 gene

Disorders / Diseases
for CCNA1 gene

Publications
for CCNA1 gene

Intellectual Property
for CCNA1 gene

Products
for CCNA1 gene