V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CCNA1 Gene

protein-coding GIFtS: 66

GC13P035904

cyclin A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
cyclin A1 ^²

External Ids
HGNC: 1577¹
Entrez Gene: 8900²
UniProtKB: P78396³
Ensembl: ENSG00000133101⁷

Search outside databases for aliases for CCNA1 gene

Previous GC identifers: GC13P034993 GC13P030993 GC13P035942 GC13P034804

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCNA1:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are

characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins

function as regulators of CDK kinases. Different cyclins exhibit distinct expression and

degradation patterns which contribute to the temporal coordination of each mitotic event. The

cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several

leukemic cell lines, and is thought to primarily function in the control of the germline meiotic

cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase

activities, one appearing in S phase, the other in G2, and thus regulate separate functions in

cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family

proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis)

transitions. May primarily function in the control of the germline meiotic cell cycle and

additionally in the control of mitotic cell cycle in some somatic cells

Gene Wiki entry for CCNA1 (Cyclin_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCNA1 gene

Entrez Gene cytogenetic band: 13q12.3-q13 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q12.3-q13

CCNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P035904: (about GC identifiers)

Start:	35,904,495 bp from pter
End:	35,915,008 bp from pter
Size:	10,514 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396 (See protein sequence)

Recommended Name: Cyclin-A1

Size: 465 amino acids; 52358 Da

Subunit: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase

holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind

CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and

RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1

and KLHDC9

Subcellular location: Nucleus (By similarity)

Developmental stage: Expression increases in early G1 phase and reaches highest levels during the S

and G2/M phases

Secondary accessions: Q5T3V0 Q5U0G2 Q8IY91

Alternative splicing: 2 isoforms: P78396-1 P78396-2

REFSEQ proteins (4 alternative transcripts):

NP_001104515.1 NP_001104516.1 NP_001104517.1 NP_003905.1

ENSEMBL proteins:

ENSP00000255465

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CCNA1
	Recombinant Proteins from Abcam (Cyclin A1)
	Human Recombinant Proteins from Abnova (CCNA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	9041194
GO:0015630	microtubule cytoskeleton	IDA	11256614

About this table

Antibodies for CCNA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CCNA1
	Sigma-Aldrich Antibodies for CCNA1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cyclin A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCNA1)
	Novus Biologicals Antibodies for CCNA1

Assays for CCNA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P78396

ProtoNet protein and cluster: P78396

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCNA1)
		Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CCNA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003914

Applied Biosystems Silencer® siRNAs for CCNA1

Sigma-Aldrich siRNA and siRNA Panels for CCNA1

Sigma-Aldrich shRNA Panels and shRNA for CCNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111045
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111045
untagged cDNA clones in CMV expression vector (see all 5): NM_001111045

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003914

UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396

Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis)

transitions. May primarily function in the control of the germline meiotic cell cycle and

additionally in the control of mitotic cell cycle in some somatic cells

Genatlas biochemistry entry for CCNA1:

cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several

leukemic cell lines,regulator of cell-cycle

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccna1):

endocrine/exocrine gland

reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15232106 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CCNA1 (Your Favorite Gene powered by Ingenuity)

Aryl Hydrocarbon Receptor Signaling
Acute Myeloid Leukemia Signaling

GeneDecks CCNA1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CCNA1

5/110 Interacting proteins for CCNA1 (P78396^{1, 2} ENSP00000255465³) via UniProtKB, MINT, and/or STRING (see all 110 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MCM4	P33991¹^,², ENSP00000262105³	EBI-375065, EBI-374938 MINT-50427 EBI-375065, EBI-374938 MINT-50427 STRING (score=.999)
MCM6	Q14566¹^,², ENSP00000264156³	EBI-375065, EBI-374900 MINT-50428 EBI-375065, EBI-374900 MINT-50428 STRING (score=.999)
CDKN1A	P38936¹^,²	EBI-375065, EBI-375077 MINT-50429 EBI-375065, EBI-375077 MINT-50429
KIAA1967	Q8N163¹	EBI-375065, EBI-355410
MCC	P23508¹	EBI-375065, EBI-307531

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--
GO:0007141	male meiosis I	TAS	9843212
GO:0007283	spermatogenesis	TAS	9843212
GO:0051301	cell division	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CCNA1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CCNA1
2 PharmGKB drug compound relationships for CCNA1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCNA1)
		Millipore RNAi Products for the Analysis of CCNA1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CCNA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003914

Sigma-Aldrich siRNA and siRNA Panels for CCNA1

Sigma-Aldrich shRNA Panels and shRNA for CCNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111045 NM_001111046 NM_001111047 NM_003914

REFSEQ mRNAs for CCNA1 gene (4 alternative transcripts):

NM_001111045.1 NM_001111046.1 NM_001111047.1 NM_003914.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111045 NM_001111046 NM_001111047 NM_003914

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111045
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111045
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001111045

Additional cDNA sequence:

AK225146.1 AK301897.1 AK314261.1 AK316392.1 BC035479.1 BC036346.1 BT019577.1 CR616879.1

U66838.1 U97680.1

3 DOTS entries:

DT.113428 DT.75122607 DT.95165865

24/68 AceView cDNA sequences (see all 68 ):

F13244 AA420962 AA421060 BC036346 BX281383 BC035479 F10846 CR616879

AA777001 BM552862 AI168235 CN480841 F10700 BE336946 AA843121 BE242234

AA758807 BI770520 AL039286 AW237229 BI459787 BI825398 NM_003914 U66838

highest scoring ESTs for CCNA1:

U66838 AA420962 AA553454 AA758620 AA758807 AA777001 AA843121 AI168235 AI377233 AI431692

Unigene Cluster for CCNA1:

Cyclin A1

Hs.417050 [show with all ESTs]

Unigene Representative Sequence: NM_003914

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:
SP3:							-		-
SP4:							-		-
SP5:			-		-		-		-

About this scheme

ECgene alternative splicing isoforms for CCNA1

1 Ensembl transcript including schematic representation:

ENST00000255465

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCNA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCNA1

¹ / ² / ³

3 probe-sets matching CCNA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1914_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U66838	1.00	1.00	1.00	1
205899_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003914	0.60	1.00	0.82	1
205899_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGCCACCTG

SOURCE GeneReport for Unigene cluster: Hs.417050
Expression variation in blood from EXPOLDB for CCNA1
UniProtKB/Swiss-Prot: CCNA1_HUMAN, P78396
Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid
Leukemia cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCNA1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCNA1¹	--	cyclin A1	88.26(n) 88.26(a)	477302 XM_534494.2 XP_534494.2
chimpanzee (Pan troglodytes)	CCNA1¹	--	cyclin A1	99.43(n) 99.35(a)	467260 XM_522658.2 XP_522658.2
cow (Bos taurus)	CCNA1¹	--	cyclin A1	86.54(n) 87.17(a)	521939 XM_600212.3 XP_600212.3
rat (Rattus norvegicus)	Ccna1¹	--	cyclin A1	83.53(n) 84.56(a)	295052 NM_001011949.1 NP_001011949.1
mouse (Mus musculus)	Ccna1^{1, 5}	3⁵	cyclin A1^{1, 5}	83.14(n)¹ 84.09(a)¹	12427¹ NM_007628.2¹ NP_031654.1¹ AK077114⁵ BB573804⁵ (see all 9)

About this table Species with no ortholog for CCNA1

ENSEMBL Gene Tree for CCNA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCNA1 gene

CCNO² CCNA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in CCNA1 are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7985423^1,2	A,C,F,H	35904463(+)	`CCAGGC/GTGGAA`	2	--	ut5¹		3		EU EA	294
	rs3814803^1,2	C,F,H	35902964(-)	`ATTGCC/TGCAAC`	1	--	ng5¹		8		EU EA WA NA	776
	rs3814805^1,2	C,F	35902716(-)	`GCTCAC/GGAGAC`	1	--	ng5¹		4		NA EA	362
--	rs11839265^1,2	A,C	35904582(+)	`GCCCTG/TCCCCG`	2	--	ut5¹ ese³		0	--	--	--	--
	rs3829943^1,2	C	35903739(-)	`CACGTC/GGTGCT`	1	--	ng5¹		0	--	--	--	--
	rs3829944^1,2	C	35903290(-)	`ATCACA/CGTTTT`	1	--	ng5¹		0	--	--	--	--
	rs2282411^1,2	A,C,F,H,O	35912366(-)	`TTTTAC/TGCTCC`	1	--	int¹		13		EA EU WA NA	2542
	rs4245378^1,2	A,C,F,H	35905040(+)	`TAATTG/ACTGGG`	1	--	int¹		4		EU EA WA	412
	rs947317^1,2	C,F,H,O	35910044(-)	`GGTACC/GATCAG`	1	--	int¹		7		NA EU EA WA	558
--	rs7986631^1,2	A,C,F,H	35908294(+)	`gaaatG/Aaaaag`	1	--	int¹		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for CCNA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604036

10/12 Novoseek disease relationships for CCNA1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	54.75	5	11381140 (2), 11090075 (1), 10590070 (1)
leukemia	33.32	13	10068680 (3), 18559500 (2), 17455244 (2), 18787932 (1) (see all 6)
leukemia promyelocytic acute	29.40	3	11090075 (3)
testicular cancer	28.81	1	14510182 (1)
retinoblastoma	27.05	3	17455244 (3)
wilms tumor	25.66	2	15526363 (1)
tumors	23.00	19	18612129 (3), 14696091 (2), 18027847 (2), 16799873 (2) (see all 10)
osteosarcoma	12.48	1	10757815 (1)
lymphoblastic leukemia acute	11.34	1	16102826 (1)
cancer	5.98	3	11212263 (1), 16524460 (1)

About this table

1 PharmGKB disease relationship for CCNA1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12086872 12704389 12730115

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/111 PubMed articles for CCNA1 gene (see all 111 ):

Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PubMed id 9041194)^{1, 2, 3, 4} Yang R.... Koeffler H.P. (1997)
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PubMed id 10022926)^{1, 3, 4} Yang R.... Koeffler H.P. (1999)
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PubMed id 15159402)^{3, 4} Diederichs S.... Muller-Tidow C. (2004)
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. (PubMed id 18612129)^{1, 3} Wegiel B....Persson J.L. (2008)
A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. (PubMed id 16007189)^{1, 3} Wegiel B....Persson J.L. (2005)
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. (PubMed id 17455244)^{1, 3} Ji P....Muller-Tidow C. (2007)
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. (PubMed id 11381140)^{1, 3} Liao C....Wolgemuth D.J. (2001)
Cyclin A1 expression in leukemia and normal hematopoietic cells. (PubMed id 10068680)^{1, 3} Yang R....Koeffler H.P. (1999)
Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. (PubMed id 16799873)^{1, 3} Rivera A....Maxwell S.A. (2006)
Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology. (PubMed id 11172814)^{1, 3} Muller-Tidow C....Serve H. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8900	HGNC: 1577	AceView: CCNA1	Ensembl:ENSG00000133101	euGenes: HUgn8900
ECgene: CCNA1	H-InvDB: CCNA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CCNA1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CCNA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CCNA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCNA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCNA1		Antibodies for CCNA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CCNA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CCNA1)
	Antibodies (CCNA1)
	Chimera RNAi (CCNA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Cyclin A1)
	Antibodies (Cyclin A1)

Search OriGene for CCNA1

Search Tocris compounds for CCNA1

	Drugs/Proteins for CCNA1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCNA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CCNA1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

CCNA1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CCNA1

Summaries
for CCNA1

Genomic Location
for CCNA1

Proteins
for CCNA1

Protein Domains/
Families
for CCNA1

Gene Function
for CCNA1

Pathways & Interactions
for CCNA1

Drugs & Compounds
for CCNA1

Transcripts
for CCNA1

Expression
for CCNA1

Orthologs
for CCNA1

Paralogs
for CCNA1

SNPs/Variants
for CCNA1

Disorders & Mutations
for CCNA1

Medical News
for CCNA1

Publications
for CCNA1

Search for CCNA1

Genome Databases showing CCNA1

Other Databases showing CCNA1

Specialized Databases showing CCNA1

Licensable Technologies
for CCNA1

Services
for CCNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCNA1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CCNA1

Summariesfor CCNA1

Genomic Locationfor CCNA1

Proteinsfor CCNA1

Protein Domains/Familiesfor CCNA1

Gene Functionfor CCNA1

Pathways & Interactionsfor CCNA1

Drugs & Compoundsfor CCNA1

Transcriptsfor CCNA1

Expression for CCNA1

Orthologsfor CCNA1

Paralogsfor CCNA1

SNPs/Variantsfor CCNA1

Disorders & Mutationsfor CCNA1

Medical Newsfor CCNA1

Publicationsfor CCNA1

Search for CCNA1

Genome Databases showing CCNA1

Other Databases showing CCNA1

Specialized Databases showing CCNA1

Licensable Technologiesfor CCNA1

Servicesfor CCNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCNA1

Summaries
for CCNA1

Genomic Location
for CCNA1

Proteins
for CCNA1

Protein Domains/
Families
for CCNA1

Gene Function
for CCNA1

Pathways & Interactions
for CCNA1

Drugs & Compounds
for CCNA1

Transcripts
for CCNA1

Expression
for CCNA1

Orthologs
for CCNA1

Paralogs
for CCNA1

SNPs/Variants
for CCNA1

Disorders & Mutations
for CCNA1

Medical News
for CCNA1

Publications
for CCNA1

Licensable Technologies
for CCNA1

Services
for CCNA1