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CCM2L Gene

protein-coding   GIFtS: 39
GCID: GC20P030601

Cerebral Cavernous Malformation 2-Like

(Previous name: chromosome 20 open reading frame 160)
(Previous symbol: C20orf160)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cerebral Cavernous Malformation 2-Like1 2
C20orf1601 2 3
CCM2-like2 3
Chromosome 20 Open Reading Frame 1601
Cerebral Cavernous Malformations 2 Protein-Like2
dJ310O13.52

External Ids:    HGNC: 161531   Entrez Gene: 1407062   Ensembl: ENSG000001013317   UniProtKB: Q9NUG43   

Export aliases for CCM2L gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCM2L Gene:
CCM2L (cerebral cavernous malformation 2-like) is a protein-coding gene. Diseases associated with CCM2L include cerebral cavernous malformations-2, and cavernous malformation. An important paralog of this gene is CCM2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCM2L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCM2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCM2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

CCM2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCM2L gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030601:  view genomic region     (about GC identifiers)

Start:
30,598,245 bp from pter      End:
30,619,984 bp from pter
Size:
21,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCM2L_HUMAN, Q9NUG4 (See protein sequence)
Recommended Name: Cerebral cavernous malformations 2 protein-like  
Size: 571 amino acids; 62179 Da
Sequence caution: Sequence=AAH32455.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5JYR9 Q8N5F1 Q8N6G8 Q96MD5
Alternative splicing: 3 isoforms:  Q9NUG4-1   Q9NUG4-2   Q9NUG4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCM2L: NX_Q9NUG4

Explore proteomics data for CCM2L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCM2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542192.2  
    ENSEMBL proteins: 
     ENSP00000262659   ENSP00000392448   ENSP00000300415  

    CCM2L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CCM2L Antibody Products:

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    OriGene Custom Antibody Services for CCM2L
    Novus Biologicals CCM2L Antibodies
    Search for Antibodies for CCM2L at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CCM2L
    LSBio Antibodies in human, mouse, rat for CCM2L

    CCM2L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026159 Malcavernin

    Graphical View of Domain Structure for InterPro Entry Q9NUG4

    ProtoNet protein and cluster: Q9NUG4

    UniProtKB/Swiss-Prot: CCM2L_HUMAN, Q9NUG4
    Similarity: Belongs to the CCM2 family


    CCM2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    CCM2L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCM2L:
     Decreased circadian period len 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccm2l):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  muscle 
     normal  tumorigenesis 

    CCM2L for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCM2L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCM2L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCM2L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCM2L

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCM2L:
    hsa-mir-124-3p (MIRT022811)

    Block miRNA regulation of human, mouse, rat CCM2L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCM2L
    SwitchGear 3'UTR luciferase reporter plasmidCCM2L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCM2L
    Predesigned siRNA for gene silencing in human, mouse, rat CCM2L

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCM2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCM2L

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCM2L 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCM2L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    CCM2L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCM2L
    Interactions:

        Search GeneGlobe Interaction Network for CCM2L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CCM2L (Q9NUG43 ENSP000002626594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CCM2L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCM2L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCM2L gene: 
    NM_080625.3  

    Unigene Cluster for CCM2L:

    Cerebral cavernous malformation 2-like
    Hs.382151  [show with all ESTs]
    Unigene Representative Sequence: BC030254
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262659 ENST00000452892 ENST00000300415(uc002wxf.2 uc002wxg.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCM2L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCM2L
    SwitchGear 3'UTR luciferase reporter plasmidCCM2L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCM2L
    Predesigned siRNA for gene silencing in human, mouse, rat CCM2L
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CCM2L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCM2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCM2L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCM2L
    OriGene qSTAR qPCR primer pairs in human, mouse for CCM2L
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CCM2L
      QuantiTect SYBR Green Assays in human, mouse, rat CCM2L
      QuantiFast Probe-based Assays in human, mouse, rat CCM2L

    Additional mRNA sequence: 

    AK057090.1 AK125588.1 BC030254.1 BC032455.1 

    5 DOTS entries:

    DT.441043  DT.95106582  DT.101976907  DT.95366525  DT.101967700 

    2 AceView cDNA sequences:

    BG911322 BC019892 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCM2L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                          -     -     -     -     -     -     -     -                                       
    SP2:                                                  -           -                       -                     
    SP3:                                                  -                                                         
    SP4:                                                                                      -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CCM2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCM2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCM2L Expression
    About this image


    CCM2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
     
     Spleen (Hematopoietic System)
    CCM2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCM2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382151
        Custom PCR Arrays for CCM2L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCM2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCM2L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccm2l1 , 5 cDNA sequence BC0205355
    cerebral cavernous malformation 2-like1
    86.48(n)1
    86.95(a)1
      2 (75.41 cM)5
    2287881  NM_145536.31  NP_663511.21 
     1530659555 
    chicken
    (Gallus gallus)
    Aves C20ORF1601 chromosome 20 open reading frame, human C20orf160 77.58(n)
    80.99(a)
      419279  XM_004947173.1  XP_004947230.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCM2L6
    cerebral cavernous malformation 2-like
    63(a)
    1 ↔ 1
    GL344509.1(32173-50831)
    zebrafish
    (Danio rerio)
    Actinopterygii ccm2l1 cerebral cavernous malformation 2-like 69.53(n)
    71.89(a)
      568661  XM_692004.5  XP_697096.5 


    ENSEMBL Gene Tree for CCM2L (if available)
    TreeFam Gene Tree for CCM2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCM2L gene
    CCM22  
    1 SIMAP similar gene for CCM2L using alignment to 2 protein entries:     CCM2L_HUMAN (see all proteins):
    CCM2

    CCM2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCM2L (see all 493)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899403341,2
    --30596254(+) CTGACA/GCCAAG 1 -- us2k10--------
    rs1172053061,2
    F--30596330(+) CAGAAC/ACCAGG 1 -- us2k12Minor allele frequency- A:0.01NA EA 240
    rs1504215641,2
    --30596401(+) GCAGAA/CTGCAT 1 -- us2k10--------
    rs1122758511,2
    C,F--30596586(+) TGTAAA/CGTGTT 1 -- us2k12Minor allele frequency- C:0.05CSA WA 120
    rs772185761,2
    F--30596670(+) GAACAT/AGGTCA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1825285601,2
    --30596697(+) ACTAAC/TGTTAA 1 -- us2k10--------
    rs1140083691,2
    F--30596870(+) CTTCCG/ACAAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs731026861,2
    C,F--30596931(+) TATTGA/GTCTTT 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs595533111,2
    C--30597173(+) TTTTT-/TCAGTT 1 -- us2k10--------
    rs114811111,2
    C--30597184(+) TTTTTT/-GAGAT 1 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CCM2L (30598245 - 30619984 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCM2L: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCM2L
    DNA2.0 Custom Variant and Variant Library Synthesis for CCM2L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for CCM2L:    
    About MalaCards
    cerebral cavernous malformations-2    cavernous malformation    cerebral cavernous malformation    cerebritis
    hepatitis b    hepatitis


    CCM2L for disorders           About GeneDecksing


    Export disorders for CCM2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCM2L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCM2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140706 HGNC: 16153 AceView: C20orf160.1 Ensembl:ENSG00000101331 euGenes: HUgn140706
    ECgene: CCM2L H-InvDB: CCM2L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCM2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCM2L gene:
    Search GeneIP for patents involving CCM2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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