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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL8 Gene

protein-coding   GIFtS: 60
GCID: GC17P032646

Chemokine (C-C Motif) Ligand 8

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 8...)
(Previous symbol: SCYA8)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 81 2     HC142 3
SCYA81 2 3 5     MCP-22 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte
Chemotactic Protein 2)1 2
     MCP22 3
Monocyte Chemoattractant Protein 22 3     SCYA102 3
Monocyte Chemotactic Protein 22 3     C-C Motif Chemokine 82
Small-Inducible Cytokine A82 3     

External Ids:    HGNC: 106351   Entrez Gene: 63552   Ensembl: ENSG000001087007   OMIM: 6022835   UniProtKB: P800753   

Export aliases for CCL8 gene to outside databases

Previous GC identifers: GC17P032416 GC17P034685 GC17P032791 GC17P029670 GC17P028831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL8 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine
is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays
chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of
inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state
against HIV infection. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL8 Gene: 
CCL8 (chemokine (C-C motif) ligand 8) is a protein-coding gene. Diseases associated with CCL8 include vernal keratoconjunctivitis, and bullous pemphigoid, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not
show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of
CCL2 and CCL5 and CCL8

Gene Wiki entry for CCL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL8 gene promoter:
         Brachyury   C/EBPalpha   NF-AT   YY1   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032646:  view genomic region     (about GC identifiers)

Start:
32,646,055 bp from pter      End:
32,648,421 bp from pter
Size:
2,367 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075 (See protein sequence)
Recommended Name: C-C motif chemokine 8 precursor  
Size: 99 amino acids; 11246 Da
Subunit: Monomer or homodimer; in equilibrium
Subcellular location: Secreted
Sequence caution: Sequence=CAA68168.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CCL8:
1ESR (3D)    
Secondary accessions: A0AV77 P78388

Explore the universe of human proteins at neXtProt for CCL8: NX_P80075

Post-translational modifications:

  • UniProtKB: N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood
    monocytes
  • View neXtProt modification sites for NX_P80075

  • CCL8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_005614.2  
    ENSEMBL proteins: 
     ENSP00000378118  

    Human Recombinant Protein Products for CCL8: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL8
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    Novus Biologicals CCL8 Proteins
    Sino Biological Recombinant Protein for CCL8
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL8
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CCL8 for ontologies           About GeneDecksing



    CCL8 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CCL8 

    Assay Products for CCL8: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL8 (CCL8/MCP-2)         (see all)
    GenScript Custom Assay Services for CCL8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P80075

    ProtoNet protein and cluster: P80075

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL8_HUMAN, P80075
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
    neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not
    show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of
    CCL2 and CCL5 and CCL8
    Induction: By IFNG/IFN-gamma, mitogens and IL1/interleukin-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10734056
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
    GO:0016004phospholipase activator activity IDA10734056
         
    CCL8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL8 

    miRNA
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    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidCCL8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL8
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    Gene Editing
    Products:
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    Clone
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    Sino Biological Human cDNA Clone for CCL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL8
    Sirion Biotech Customized lentivirus for stable overexpression of CCL8 
                         Customized lentivirus expression plasmids for stable overexpression of CCL8 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL8 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CCL8
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL8 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL8
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils



    2         Kegg Pathways  (Kegg details for CCL8):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL8

    5/11 Interacting proteins for CCL8 (P800753) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR2O005903I2D: score=4 
    VCANP136113I2D: score=4 
    CCR1P322463I2D: score=3 
    ACKR4Q9NPB93I2D: score=2 
    CCR5P516813I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10734056
    GO:0006816calcium ion transport IDA10734056
    GO:0006874cellular calcium ion homeostasis IDA10734056
    GO:0006887exocytosis IDA10734056
    GO:0006935chemotaxis IEA--

    CCL8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL8

    1 DrugBank Compound for CCL8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyroglutamic Acid-- 98-79-3target----

    10/15 Novoseek inferred chemical compound relationships for CCL8 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.9 104 7531149 (5), 11090473 (4), 11861332 (4), 7514401 (3) (see all 66)
    ccl3 73.6 8 18565769 (2), 17386409 (1), 19406226 (1), 17698927 (1) (see all 6)
    tarc 57.5 3 9153236 (1), 10372118 (1), 10887135 (1)
    pyroglutamate 42.1 3 9730840 (2), 11087354 (1)
    ccl4 37.6 5 18565769 (2), 17386409 (1), 18340639 (1), 19067439 (1)
    peptidoglycan 32.6 2 16034120 (1), 14707104 (1)
    calcium 32.4 12 8144937 (2), 9558113 (2), 7662986 (2), 9009224 (1) (see all 8)
    fmlp 13.5 2 9688329 (2)
    leukotriene b4 12.1 2 7639692 (1), 8276799 (1)
    threonine 1.64 1 8144937 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL8 gene: 
    NM_005623.2  

    Unigene Cluster for CCL8:

    Chemokine (C-C motif) ligand 8
    Hs.271387  [show with all ESTs]
    Unigene Representative Sequence: Y16645
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000394620(uc002hib.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL8
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL8 (see all 9):
    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidCCL8 3' UTR sequence
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL8

    Additional mRNA sequence: 

    BC126242.1 Y10802.1 Y16645.1 

    1 DOTS entry:

    DT.107818 

    24/39 AceView cDNA sequences (see all 39):

    BQ027203 NM_005623 BM725214 AI380244 AV681729 AW291258 CA435963 AI085069 
    AA989086 AI168344 AI872946 AI093810 BU623685 BQ771777 AV733664 Y10802 
    BU626657 Y16645 AI590222 AI400658 AW302168 AI268937 BM678226 AV734258 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCATCAAG
    CCL8 Expression
    About this image


    Genevestigator expression for CCL8

    SOURCE GeneReport for Unigene cluster: Hs.271387

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate
    levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low
    levels seen in the brain, liver, spleen and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL8 (see all 8): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL8 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.36
    si:dkeyp-59a8.26
    (see all 5)
    si:dkeyp-59a8.2
    (see all 5)
    33(a)
    31(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38310380-38311158)
    20(38304232-38305101)
            Species with no ortholog for CCL8

    ENSEMBL Gene Tree for CCL8 (if available)
    TreeFam Gene Tree for CCL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL8 gene
    CCL112  CCL132  CCL72  CCL22  CCL242  
    18/28 SIMAP similar genes for CCL8 using alignment to 2 protein entries:     CCL8_HUMAN (see all proteins) (see all similar genes):
    CCL11    CCL2    CCL7    MCP-3    CCL13    XCL1
    XCL2    CCL3L1    CCL3L3    CCL4    CCL4L2    CX3CL1
    LOC728835    CCL14    CCL3    CCL4L1    CCL17    CCL5

    CCL8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 SNPs in CCL8 are shown (see all 205)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847356211,2
    --32644119(+) GAAAAC/TTTTTT 1 -- us2k10--------
    rs124493081,2
    C,F,H--32644191(+) gagggA/Gtactt 1 -- us2k18Minor allele frequency- G:0.16NS EA NA WA 782
    rs713794731,2
    C,F--32644275(+) TTCTCC/TTAAGA 1 -- us2k16Minor allele frequency- T:0.13NA CSA WA EA 364
    rs1481720381,2
    --32644354(+) CACAAC/TAGCAC 1 -- us2k10--------
    rs1899942471,2
    --32644505(+) CTACAA/GGATAC 1 -- us2k10--------
    rs1813025241,2
    --32644687(+) AAAGAC/TGATCT 1 -- us2k10--------
    rs1848844261,2
    --32644956(+) AAGACA/GGTGTG 1 -- us2k10--------
    rs1882246101,2
    --32645045(+) TACTAC/TATACA 1 -- us2k10--------
    rs1818338261,2
    --32645046(+) ACTATA/GTACAT 1 -- us2k10--------
    rs1419794461,2
    --32645050(+) TATACA/GTACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL8 (32646055 - 32648421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602283    OMIM disorders: --

    20/42 diseases for CCL8 (see all 42):    About MalaCards
    vernal keratoconjunctivitis    bullous pemphigoid    cytomegalovirus infection    cholera
    chorioamnionitis    diffuse gastric cancer    bronchopulmonary dysplasia    keratoconjunctivitis
    primary biliary cirrhosis    tonsillitis    osteosarcoma    dermatomyositis
    multiple sclerosis    bronchiolitis    allergic rhinitis    rhinitis
    hepatitis c    meningitis    encephalomyelitis    non-hodgkin lymphoma


    CCL8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for CCL8 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 41.1 5 15901268 (3), 17386409 (1)
    osteosarcoma 32.3 3 9070881 (1), 9730840 (1), 8189067 (1)
    immunodeficiency 23.7 6 11930329 (1), 12539042 (1), 11278962 (1), 12837756 (1) (see all 5)
    necrosis 19.2 12 14693736 (1), 19220953 (1), 17021345 (1), 19551822 (1) (see all 7)
    tumors 13.5 15 9070881 (1), 14693736 (1), 19220953 (1), 17021345 (1) (see all 9)
    cholera 11.3 2 7662986 (1), 9688329 (1)
    leukemia 0 2 16352705 (1), 18565769 (1)
    virus infection 0 1 11467997 (1)
    hepatitis c chronic 0 1 15770052 (1)
    osteoarthritis 0 1 14707104 (1)

    Genetic Association Database (GAD): CCL8
    Human Genome Epidemiology (HuGE) Navigator: CCL8 (19 documents)

    Export disorders for CCL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL8 gene, integrated from 9 sources (see all 199):
    (articles sorted by number of sources associating them with CCL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. (PubMed id 9119400)1, 2, 3, 9 van Coillie E.... Opdenakker G. (1997)
    2. Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells. (PubMed id 9070881)1, 2, 9 van Coillie E.... Opdenakker G. (1997)
    3. Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. (PubMed id 11087354)1, 2, 9 Blaszczyk J.... Ji X. (2000)
    4. Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP- 2(6-76) as a natural chemokine inhibitor. (PubMed id 9558113)1, 2, 9 Proost P.... Van Damme J. (1998)
    5. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)1, 2, 9 van Damme J.... Opdenakker G. (1992)
    6. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)1, 2, 9 Kim K.-S.... Sykes B.D. (1996)
    7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    8. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    9. Genetic variants of CC chemokine genes in experimenta l autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (2010)
    10. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6355 HGNC: 10635 AceView: CCL8 Ensembl:ENSG00000108700 euGenes: HUgn6355
    ECgene: CCL8 Kegg: 6355 H-InvDB: CCL8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL8

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL8 gene:
    Search GeneIP for patents involving CCL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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