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Aliases for CCL8 Gene

Aliases for CCL8 Gene

  • Chemokine (C-C Motif) Ligand 8 2 3
  • SCYA8 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2) 2 3
  • Monocyte Chemoattractant Protein 2 3 4
  • Monocyte Chemotactic Protein 2 3 4
  • Small-Inducible Cytokine A8 3 4
  • SCYA10 3 4
  • MCP-2 3 4
  • HC14 3 4
  • MCP2 3 4
  • C-C Motif Chemokine 8 3

External Ids for CCL8 Gene

Previous HGNC Symbols for CCL8 Gene

  • SCYA8

Previous GeneCards Identifiers for CCL8 Gene

  • GC17P032416
  • GC17P034685
  • GC17P032791
  • GC17P029670
  • GC17P032646
  • GC17P028831

Summaries for CCL8 Gene

Entrez Gene Summary for CCL8 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL8 Gene

CCL8 (Chemokine (C-C Motif) Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include diffuse gastric cancer and cholera. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL8 Gene

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.

Gene Wiki entry for CCL8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL8 Gene

Genomics for CCL8 Gene

Regulatory Elements for CCL8 Gene

Genomic Location for CCL8 Gene

Start:
34,319,036 bp from pter
End:
34,321,402 bp from pter
Size:
2,367 bases
Orientation:
Plus strand

Genomic View for CCL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL8 Gene

Proteins for CCL8 Gene

  • Protein details for CCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80075-CCL8_HUMAN
    Recommended name:
    C-C motif chemokine 8
    Protein Accession:
    P80075
    Secondary Accessions:
    • A0AV77
    • P78388

    Protein attributes for CCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11246 Da
    Quaternary structure:
    • Monomer or homodimer; in equilibrium.
    SequenceCaution:
    • Sequence=CAA68168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL8 Gene

neXtProt entry for CCL8 Gene

Proteomics data for CCL8 Gene at MOPED

Post-translational modifications for CCL8 Gene

  • N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CCL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CCL8 Gene

Domains for CCL8 Gene

Gene Families for CCL8 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL8 Gene

Suggested Antigen Peptide Sequences for CCL8 Gene

Graphical View of Domain Structure for InterPro Entry

P80075

UniProtKB/Swiss-Prot:

CCL8_HUMAN :
  • P80075
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL8: view

Function for CCL8 Gene

Molecular function for CCL8 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma, mitogens and IL1/interleukin-1

Gene Ontology (GO) - Molecular Function for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10734056
GO:0008009 chemokine activity IEA --
GO:0008201 heparin binding IEA --
GO:0016004 phospholipase activator activity IDA 10734056
genes like me logo Genes that share ontologies with CCL8: view

Phenotypes for CCL8 Gene

GenomeRNAi human phenotypes for CCL8:
genes like me logo Genes that share phenotypes with CCL8: view

Animal Model Products

CRISPR Products

miRNA for CCL8 Gene

miRTarBase miRNAs that target CCL8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL8 Gene

Localization for CCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL8 Gene COMPARTMENTS Subcellular localization image for CCL8 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL8: view

Pathways for CCL8 Gene

genes like me logo Genes that share pathways with CCL8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
    • HIV Host Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 10734056
GO:0006816 calcium ion transport IDA 10734056
GO:0006874 cellular calcium ion homeostasis IDA 10734056
GO:0006887 exocytosis IDA 10734056
GO:0006935 chemotaxis TAS 9468473
genes like me logo Genes that share ontologies with CCL8: view

Compounds for CCL8 Gene

(1) Drugbank Compounds for CCL8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyroglutamic Acid
98-79-3 target

(15) Novoseek inferred chemical compound relationships for CCL8 Gene

Compound -log(P) Hits PubMed IDs
rantes 90.9 89
ccl3 73.6 7
tarc 57.5 3
pyroglutamate 42.1 3
ccl4 37.6 5
genes like me logo Genes that share compounds with CCL8: view

Transcripts for CCL8 Gene

mRNA/cDNA for CCL8 Gene

(39) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL8 Gene

Chemokine (C-C motif) ligand 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL8 Gene

No ASD Table

Relevant External Links for CCL8 Gene

GeneLoc Exon Structure for
CCL8
ECgene alternative splicing isoforms for
CCL8

Expression for CCL8 Gene

mRNA expression in normal human tissues for CCL8 Gene

mRNA differential expression in normal tissues according to GTEx for CCL8 Gene

This gene is overexpressed in Colon - Transverse (6.9) and Adipose - Visceral (Omentum) (5.3).

SOURCE GeneReport for Unigene cluster for CCL8 Gene Hs.271387

mRNA Expression by UniProt/SwissProt for CCL8 Gene

P80075-CCL8_HUMAN
Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate
genes like me logo Genes that share expressions with CCL8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CCL8 Gene

Orthologs for CCL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL8 35
  • 98.99 (n)
  • 98.99 (a)
CCL8 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL8 35
  • 81.14 (n)
  • 68.69 (a)
CCL8 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL8 35
  • 79.8 (n)
  • 70.71 (a)
CCL8 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl12 36
  • 57 (a)
OneToMany
Ccl8 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
Species with no ortholog for CCL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL8 Gene

ENSEMBL:
Gene Tree for CCL8 (if available)
TreeFam:
Gene Tree for CCL8 (if available)

Paralogs for CCL8 Gene

Paralogs for CCL8 Gene

genes like me logo Genes that share paralogs with CCL8: view

Variants for CCL8 Gene

Sequence variations from dbSNP and Humsavar for CCL8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1133763 - 34,320,812(+) AGACC(A/C)AACGG reference, missense
rs3138035 -- 34,318,930(+) CTCTG(C/T)AACAG upstream-variant-2KB
rs3138036 -- 34,320,525(+) AGTCC(A/G)TGAGA intron-variant
rs3138037 -- 34,320,725(+) TCAGT(C/T)CTAGG intron-variant
rs11342894 -- 34,321,860(+) ATACC(-/A)GAGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCL8 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Relevant External Links for CCL8 Gene

HapMap Linkage Disequilibrium report
CCL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL8 Gene

Disorders for CCL8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CCL8 Gene including...

Search for CCL8 Gene in MalaCards »

(12) Novoseek inferred disease relationships for CCL8 Gene

Disease -log(P) Hits PubMed IDs
inflammation 41.1 4
osteosarcoma 32.3 3
immunodeficiency 23.7 5
necrosis 19.2 7
tumors 13.5 9

Relevant External Links for CCL8

Genetic Association Database (GAD)
CCL8
Human Genome Epidemiology (HuGE) Navigator
CCL8
genes like me logo Genes that share disorders with CCL8: view

No data available for UniProtKB/Swiss-Prot for CCL8 Gene

Publications for CCL8 Gene

  1. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. (PMID: 9119400) van Coillie E. … Opdenakker G. (Genomics 1997) 2 3 4 23
  2. Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. (PMID: 11087354) Blaszczyk J. … Ji X. (Biochemistry 2000) 3 4 23
  3. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PMID: 1613466) van Damme J. … Opdenakker G. (J. Exp. Med. 1992) 3 4 23
  4. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PMID: 8898111) Kim K.-S. … Sykes B.D. (FEBS Lett. 1996) 3 4 23
  5. Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells. (PMID: 9070881) van Coillie E. … Opdenakker G. (Biochem. Biophys. Res. Commun. 1997) 3 4 23

Products for CCL8 Gene

Sources for CCL8 Gene

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