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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL8 Gene

protein-coding   GIFtS: 62
GCID: GC17P032646

chemokine (C-C motif) ligand 8

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA8)
 Explore 43 diseases affiliated with
CCL8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL8    

Aliases
for CCL8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 81 2     Monocyte Chemotactic Protein 22 3
SCYA81 2 3 5     Small-Inducible Cytokine A82 3
HC141 2 3     MCP22 3
MCP-21 2 3     SCYA102 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic
Protein 2)1 2
     C-C Motif Chemokine 82
Monocyte Chemoattractant Protein 22 3     

External Ids:    HGNC: 106351   Entrez Gene: 63552   Ensembl: ENSG000001087007   OMIM: 6022835   UniProtKB: P800753   

Export aliases for CCL8 gene to outside databases

Previous GC identifers: GC17P032416 GC17P034685 GC17P032791 GC17P029670 GC17P028831


Summaries
for CCL8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL8:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted
proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally
related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a
single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils.
By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte
infiltration and to the antiviral state against HIV infection. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show
monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and
CCL5 and CCL8

Gene Wiki entry for CCL8


Genomic Views
for CCL8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL8 gene promoter:
         Brachyury   C/EBPalpha   NF-AT   YY1   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032646:  view genomic region     (about GC identifiers)

Start:
 32,646,055 bp from pter      End:
 32,648,421 bp from pter
Size:
 2,367 bases      Orientation:
 plus strand

Proteins
for CCL8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075 (See protein sequence)
Recommended Name: C-C motif chemokine 8 precursor  
Size: 99 amino acids; 11246 Da
Subunit: Monomer or homodimer; in equilibrium
Subcellular location: Secreted
Sequence caution: Sequence=CAA68168.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CCL8:
1ESR (3D)    
Secondary accessions: A0AV77 P78388

Explore the universe of human proteins at neXtProt for CCL8: NX_P80075

Post-translational modifications:

  • N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood
    • monocytes1
  • View neXtProt modification sites for NX_P80075

    • CCL8 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_005614.2  
    ENSEMBL proteins: 
     ENSP00000378118  

    Human Recombinant Protein Products for CCL8: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CCL8
    OriGene Custom Protein Services for CCL8 
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    Novus Biologicals CCL8 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL8
    Uscn Proteins for CCL8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CCL8 for ontologies           About GeneDecksing



    CCL8 Antibody Products: 
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    Uscn ELISAs and CLIAs for CCL8

    Protein Domains /
    Families
    for CCL8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCL8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P80075

    ProtoNet protein and cluster: P80075

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Function
    for CCL8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL8_HUMAN, P80075
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
    neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show
    monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and
    CCL5 and CCL8
    Induction: By IFNG/IFN-gamma, mitogens and IL1/interleukin-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10734056
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
    GO:0016004phospholipase activator activity IDA10734056
         
    CCL8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCL8 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL8
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL8 (see all 9):
    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmid: CCL8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL8
    OriGene shRNA RFP: CCL8
    OriGene siRNA: CCL8
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CCL8 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCL8 
    Sirion Biotech Customized adenovirus for potent knockdown of CCL8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL8
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL8 (NM_005623)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL8 

    Cell Line
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    Sirion Biotech Customized stable overexpressing cell line services for CCL8
    Sirion Biotech Customized inducible overexpressing cell line services for CCL8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8


    Pathways & Interactions
    for CCL8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5Cell adhesion_Cell-matrix glycoconjugates
    		Cell adhesion_Cell-matrix glycoconjugates1.00
    		Cell adhesion Cell-matrix glycoconjugates0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CCL8
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL8 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL8
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils


    2         Kegg Pathways  (Kegg details for CCL8):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL8

    5/11 Interacting proteins for CCL8 (P800753) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCBP2O005903I2D: score=4 
    VCANP136113I2D: score=4 
    CCR1P322463I2D: score=3 
    CCR5P516813I2D: score=2 
    CCRL1Q9NPB93I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10734056
    GO:0006816calcium ion transport IDA10734056
    GO:0006874cellular calcium ion homeostasis IDA10734056
    GO:0006887exocytosis IDA10734056
    GO:0006935chemotaxis IEA--

    CCL8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCL8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL8

    1 DrugBank Compound for CCL8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyroglutamic Acid-- 98-79-3target----

    10/15 Novoseek chemical compound relationships for CCL8 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.9 104 7531149 (5), 11090473 (4), 11861332 (4), 7514401 (3) (see all 66)
    ccl3 73.6 8 18565769 (2), 17386409 (1), 19406226 (1), 17698927 (1) (see all 6)
    tarc 57.5 3 9153236 (1), 10372118 (1), 10887135 (1)
    pyroglutamate 42.1 3 9730840 (2), 11087354 (1)
    ccl4 37.6 5 18565769 (2), 17386409 (1), 18340639 (1), 19067439 (1)
    peptidoglycan 32.6 2 16034120 (1), 14707104 (1)
    calcium 32.4 12 8144937 (2), 9558113 (2), 7662986 (2), 9009224 (1) (see all 8)
    fmlp 13.5 2 9688329 (2)
    leukotriene b4 12.1 2 7639692 (1), 8276799 (1)
    threonine 1.64 1 8144937 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL8 

    Transcripts
    for CCL8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCL8 gene: 
    NM_005623.2  

    Unigene Cluster for CCL8:

    Chemokine (C-C motif) ligand 8
    Hs.271387  [show with all ESTs]
    Unigene Representative Sequence: Y16645
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000394620(uc002hib.3)

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL8 (see all 9):
    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmid: CCL8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL8

    Additional cDNA sequence: 

    BC126242.1 Y10802.1 Y16645.1 

    1 DOTS entry:

    DT.107818 

    24/39 AceView cDNA sequences (see all 39):

    NM_005623 CA435963 AI168344 BQ771777 BQ027203 AI380244 BM725214 AI093810 
    AI872946 AA989086 AI085069 BU623685 AW291258 AV681729 AV733664 AW302168 
    AI400658 AV734258 AI379573 Y10802 AI268937 AI590222 AV681908 BM678226 

    GeneLoc Exon Structure


    Expression
    for CCL8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATCATCAAG
    CCL8 Expression
    About this image
    Genevestigator expression for CCL8

    SOURCE GeneReport for Unigene cluster: Hs.271387

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels
    seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in
    the brain, liver, spleen and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL8 (see all 8): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8

    Orthologs
    for CCL8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCL8 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkeyp-59a8.36
    zgc:1937066
    (see all 6)    		 zgc:193706
    (see all 6)    		 34(a)
    32(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 20(38310380-38311158)
    25(25902180-25904281)


    ENSEMBL Gene Tree for CCL8 (if available)
    TreeFam Gene Tree for CCL8 (if available) 

    Paralogs
    for CCL8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL8 gene
    CCL152  CCL162  CCL22  CCL142  CCL242  CCL4L12  CCL112  CCL72  
    CCL4L22  CCL3L12  CCL52  CCL232  CCL3L32  CCL42  CCL132  CCL262  
    CCL32  CCL182  
    18/29 SIMAP similar genes for CCL8 using alignment to 2 protein entries:     CCL8_HUMAN (see all proteins) (see all similar genes):
    CCL11    CCL2    CCL7    MCP-3    CCL13    XCL1
    XCL2    CCL3L1    CCL3L3    CCL4    CCL4L2    CX3CL1
    LOC728835    CCL14    CCL3    CCL4L1    CCL17    CCL5

    CCL8 for paralogs           About GeneDecksing



    Genomic Variants
    for CCL8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in CCL8 are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1847356211,2
    		--32644119(+) GAAAAC/TTTTTT 1 -- us2k10--------
    rs359824401,2
    		C--32644155(+) AAAAAA/-CTCTC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs124493081,2
    		C,F,H--32644191(+) GAGGGA/GTACTT 1 -- us2k18Minor allele frequency- G:0.16NS EA NA WA 782
    rs713794731,2
    		C,F--32644275(+) NNNNCC/TTAAGA 1 -- us2k16Minor allele frequency- T:0.13NA CSA WA EA 364
    rs1481720381,2
    		--32644354(+) CACAAC/TAGCAC 1 -- us2k10--------
    rs1899942471,2
    		--32644505(+) CTACAA/GGATAC 1 -- us2k10--------
    rs1813025241,2
    		--32644687(+) AAAGAC/TGATCT 1 -- us2k10--------
    rs1848844261,2
    		--32644956(+) AAGACA/GGTGTG 1 -- us2k10--------
    rs1882246101,2
    		--32645045(+) TACTAC/TATACA 1 -- us2k10--------
    rs1818338261,2
    		--32645046(+) ACTATA/GTACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL8 (32646055 - 32648421 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCL8
         2 CNVs: 49840 49841

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL8
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL8

    Disorders / Diseases
    for CCL8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCL8 for disorders           About GeneDecksing

    OMIM gene information: 602283    OMIM disorders: --

    20/43 diseases for CCL8 (see all 43):    About MalaCards
    graft versus host disease    vernal keratoconjunctivitis    non-hodgkin lymphoma    primary biliary cirrhosis
    bullous pemphigoid    bronchopulmonary dysplasia    systemic lupus erythematosus    keratoconjunctivitis
    allergic rhinitis    lupus erythematosus    hodgkin's lymphoma    cytomegalovirus infection
    inflammatory bowel disease    rheumatoid arthritis    multiple sclerosis    diffuse gastric cancer
    hepatitis c    chorioamnionitis    rhinitis    bronchiolitis

    10/12 Novoseek disease relationships for CCL8 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 41.1 5 15901268 (3), 17386409 (1)
    osteosarcoma 32.3 3 9070881 (1), 9730840 (1), 8189067 (1)
    immunodeficiency 23.7 6 11930329 (1), 12539042 (1), 11278962 (1), 12837756 (1) (see all 5)
    necrosis 19.2 12 14693736 (1), 19220953 (1), 17021345 (1), 19551822 (1) (see all 7)
    tumors 13.5 15 9070881 (1), 14693736 (1), 19220953 (1), 17021345 (1) (see all 9)
    cholera 11.3 2 7662986 (1), 9688329 (1)
    leukemia 0 2 16352705 (1), 18565769 (1)
    virus infection 0 1 11467997 (1)
    hepatitis c chronic 0 1 15770052 (1)
    osteoarthritis 0 1 14707104 (1)

    Genetic Association Database (GAD): CCL8
    Human Genome Epidemiology (HuGE) Navigator: CCL8 (19 documents)

    Export disorders for CCL8 gene to outside databases

    Publications
    for CCL8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL8 gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with CCL8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. (PubMed id 9119400)1, 2, 3, 9 van Coillie E.... Opdenakker G. (1997)
    2. Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells. (PubMed id 9070881)1, 2, 9 van Coillie E.... Opdenakker G. (1997)
    3. Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. (PubMed id 11087354)1, 2, 9 Blaszczyk J.... Ji X. (2000)
    4. Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP- 2(6-76) as a natural chemokine inhibitor. (PubMed id 9558113)1, 2, 9 Proost P.... Van Damme J. (1998)
    5. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)1, 2, 9 van Damme J.... Opdenakker G. (1992)
    6. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)1, 2, 9 Kim K.-S.... Sykes B.D. (1996)
    7. Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal women. (PubMed id 15607028)1, 4 Park B.L....Shin H.D. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. (PubMed id 14647058)1, 4 Hellier S....Hill A.V. (2003)
    10. Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. (PubMed id 2518726)1, 2 Chang H.C.... Reinherz E.L. (1989)

    External Searches for CCL8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CCL8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6355 HGNC: 10635 AceView: CCL8 Ensembl:ENSG00000108700 euGenes: HUgn6355
    ECgene: CCL8 Kegg: 6355 H-InvDB: CCL8

    Other Databases showing CCL8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCL8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL8

    Intellectual Property
    for CCL8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCL8 gene:
    Search GeneIP for patents involving CCL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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