Aliases for CCL8 Gene
External Ids for CCL8 Gene
Previous HGNC Symbols for CCL8 Gene
Previous GeneCards Identifiers for CCL8 Gene
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL8 Gene
CCL8 (C-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include purulent labyrinthitis and diffuse gastric cancer. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL2.
UniProtKB/Swiss-Prot for CCL8 Gene
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.