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CCL8 Gene

protein-coding   GIFtS: 60
GCID: GC17P032646

Chemokine (C-C Motif) Ligand 8

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 8...)
(Previous symbol: SCYA8)
  See CCL8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 81 2     HC142 3
SCYA81 2 3 5     MCP-22 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte
Chemotactic Protein 2)1 2
     MCP22 3
Monocyte Chemoattractant Protein 22 3     SCYA102 3
Monocyte Chemotactic Protein 22 3     C-C Motif Chemokine 82
Small-Inducible Cytokine A82 3     

External Ids:    HGNC: 106351   Entrez Gene: 63552   Ensembl: ENSG000001087007   OMIM: 6022835   UniProtKB: P800753   

Export aliases for CCL8 gene to outside databases

Previous GC identifers: GC17P032416 GC17P034685 GC17P032791 GC17P029670 GC17P028831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL8 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine
is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays
chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of
inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state
against HIV infection. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL8 Gene:
CCL8 (chemokine (C-C motif) ligand 8) is a protein-coding gene. Diseases associated with CCL8 include diffuse gastric cancer, and cholera. GO annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not
show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of
CCL2 and CCL5 and CCL8

Gene Wiki entry for CCL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL8 gene promoter:
         Brachyury   C/EBPalpha   NF-AT   YY1   PPAR-gamma1   NF-AT4   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL8 promoter sequence
   Search Chromatin IP Primers for CCL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032646:  view genomic region     (about GC identifiers)

Start:
32,646,055 bp from pter      End:
32,648,421 bp from pter
Size:
2,367 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075 (See protein sequence)
Recommended Name: C-C motif chemokine 8 precursor  
Size: 99 amino acids; 11246 Da
Subunit: Monomer or homodimer; in equilibrium
Sequence caution: Sequence=CAA68168.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CCL8:
1ESR (3D)    
Secondary accessions: A0AV77 P78388

Explore the universe of human proteins at neXtProt for CCL8: NX_P80075

Explore proteomics data for CCL8 at MOPED

Post-translational modifications: 

  • N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood
    monocytes1
  • Modification sites at neXtProt

  • See CCL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005614.2  
    ENSEMBL proteins: 
     ENSP00000378118  

    CCL8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL8
    OriGene Protein Over-expression Lysate for CCL8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL8
    GenScript Purified and Recombinant Proteins for CCL8
    Novus Biologicals CCL8 Proteins
    Sino Biological Recombinant Protein for CCL8
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL8
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for CCL8: (see all 2
                        Human CCL8 (MCP-2) Recombinant Protein Carrier-Free 100 ug

    CCL8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL8
    R&D Systems Antibodies for CCL8 (CCL8/MCP-2)
    OriGene Antibodies for CCL8
    OriGene Custom Antibody Services for CCL8
    Novus Biologicals CCL8 Antibodies
    Abcam antibodies for CCL8
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL8
    LSBio Antibodies in human, mouse, rat for CCL8

    CCL8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL8
    R&D Systems ELISAs for CCL8 (CCL8/MCP-2)         (see all)
    GenScript Custom Assay Services for CCL8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P80075

    ProtoNet protein and cluster: P80075

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL8_HUMAN, P80075
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in
    neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not
    show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of
    CCL2 and CCL5 and CCL8
    Induction: By IFNG/IFN-gamma, mitogens and IL1/interleukin-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10734056
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
    GO:0016004phospholipase activator activity IDA10734056
         
    Find genes that share ontologies with CCL8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL8:
    hsa-mir-23a-3p (MIRT050431)

    Block miRNA regulation of human, mouse, rat CCL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL8 (see all 9):
    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidCCL8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL8
    Predesigned siRNA for gene silencing in human, mouse, rat CCL8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL8

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL8 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL8 (NM_005623)
    Sino Biological Human cDNA Clone for CCL8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL8
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL8_HUMAN, P80075: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL8 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL8
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL8 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL8
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils



    2 Kegg Pathways  (Kegg details for CCL8):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL8 (see all 8): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL8

    Selected Interacting proteins for CCL8 (P800753) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR2O005903I2D: score=4 
    VCANP136113I2D: score=4 
    CCR1P322463I2D: score=3 
    ACKR4Q9NPB93I2D: score=2 
    CCR5P516813I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10734056
    GO:0006816calcium ion transport IDA10734056
    GO:0006874cellular calcium ion homeostasis IDA10734056
    GO:0006887exocytosis IDA10734056
    GO:0006935chemotaxis TAS9468473

    Find genes that share ontologies with CCL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL8

    1 DrugBank Compound for CCL8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyroglutamic Acid-- 98-79-3target----

    Selected Novoseek inferred chemical compound relationships for CCL8 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.9 104 7531149 (5), 11090473 (4), 11861332 (4), 7514401 (3) (see all 66)
    ccl3 73.6 8 18565769 (2), 17386409 (1), 19406226 (1), 17698927 (1) (see all 6)
    tarc 57.5 3 9153236 (1), 10372118 (1), 10887135 (1)
    pyroglutamate 42.1 3 9730840 (2), 11087354 (1)
    ccl4 37.6 5 18565769 (2), 17386409 (1), 18340639 (1), 19067439 (1)
    peptidoglycan 32.6 2 16034120 (1), 14707104 (1)
    calcium 32.4 12 8144937 (2), 9558113 (2), 7662986 (2), 9009224 (1) (see all 8)
    fmlp 13.5 2 9688329 (2)
    leukotriene b4 12.1 2 7639692 (1), 8276799 (1)
    threonine 1.64 1 8144937 (1)



    Find genes that share compounds with CCL8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL8 gene: 
    NM_005623.2  

    Unigene Cluster for CCL8:

    Chemokine (C-C motif) ligand 8
    Hs.271387  [show with all ESTs]
    Unigene Representative Sequence: Y16645
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000394620(uc002hib.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CCL8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL8 (see all 9):
    hsa-miR-181c hsa-miR-374b hsa-miR-181a hsa-miR-944 hsa-miR-374a hsa-miR-181d hsa-miR-3658 hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidCCL8 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL8 (NM_005623)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL8
    Primer
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    OriGene qPCR primer pairs and template standards for CCL8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL8
      QuantiTect SYBR Green Assays in human, mouse, rat CCL8
      QuantiFast Probe-based Assays in human, mouse, rat CCL8

    Additional mRNA sequence: 

    BC126242.1 Y10802.1 Y16645.1 

    1 DOTS entry:

    DT.107818 

    Selected AceView cDNA sequences (see all 39):

    BQ771777 AI168344 BU623685 AI380244 NM_005623 AV681729 AA989086 CA435963 
    AI872946 BM725214 AI093810 BQ027203 AI085069 AW291258 AI400658 AI379573 
    AV734258 AV681908 BU626657 AI590222 AI268937 AW302168 Y16645 Y10802 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCATCAAG
    CCL8 Expression
    About this image

    CCL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271387

    UniProtKB/Swiss-Prot: CCL8_HUMAN, P80075
    Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate
    levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low
    levels seen in the brain, liver, spleen and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL8 (see all 8): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL8
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL8
    QuantiTect SYBR Green Assays in human, mouse, rat CCL8
    QuantiFast Probe-based Assays in human, mouse, rat CCL8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for CCL8 (if available)
    TreeFam Gene Tree for CCL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL8 gene
    CCL112  CCL132  CCL72  CCL22  CCL242  
    Selected SIMAP similar genes for CCL8 using alignment to 2 protein entries:     CCL8_HUMAN (see all proteins) (see all similar genes):
    CCL11    CCL2    CCL7    MCP-3    CCL13    XCL1
    XCL2    CCL3L1    CCL3L3    CCL4    CCL4L2    CX3CL1
    LOC728835    CCL14    CCL3    CCL4L1    CCL17    CCL5

    Find genes that share paralogs with CCL8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL8 (see all 205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847356211,2
    --32644119(+) GAAAAC/TTTTTT 1 -- us2k10--------
    rs124493081,2
    C,F,H--32644191(+) gagggA/Gtactt 1 -- us2k18Minor allele frequency- G:0.16NS EA NA WA 782
    rs713794731,2
    C,F--32644275(+) TTCTCC/TTAAGA 1 -- us2k16Minor allele frequency- T:0.13NA CSA WA EA 364
    rs1481720381,2
    --32644354(+) CACAAC/TAGCAC 1 -- us2k10--------
    rs1899942471,2
    --32644505(+) CTACAA/GGATAC 1 -- us2k10--------
    rs1813025241,2
    --32644687(+) AAAGAC/TGATCT 1 -- us2k10--------
    rs1848844261,2
    --32644956(+) AAGACA/GGTGTG 1 -- us2k10--------
    rs1882246101,2
    --32645045(+) TACTAC/TATACA 1 -- us2k10--------
    rs1818338261,2
    --32645046(+) ACTATA/GTACAT 1 -- us2k10--------
    rs1419794461,2
    --32645050(+) TATACA/GTACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL8 (32646055 - 32648421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL8
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602283    OMIM disorders: --

    3 diseases for CCL8:    
    About MalaCards
    diffuse gastric cancer    cholera    primary biliary cirrhosis


    Find genes that share disorders with CCL8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL8 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 41.1 5 15901268 (3), 17386409 (1)
    osteosarcoma 32.3 3 9070881 (1), 9730840 (1), 8189067 (1)
    immunodeficiency 23.7 6 11930329 (1), 12539042 (1), 11278962 (1), 12837756 (1) (see all 5)
    necrosis 19.2 12 14693736 (1), 19220953 (1), 17021345 (1), 19551822 (1) (see all 7)
    tumors 13.5 15 9070881 (1), 14693736 (1), 19220953 (1), 17021345 (1) (see all 9)
    cholera 11.3 2 7662986 (1), 9688329 (1)
    leukemia 0 2 16352705 (1), 18565769 (1)
    virus infection 0 1 11467997 (1)
    hepatitis c chronic 0 1 15770052 (1)
    osteoarthritis 0 1 14707104 (1)

    Genetic Association Database (GAD): CCL8
    Human Genome Epidemiology (HuGE) Navigator: CCL8 (19 documents)

    Export disorders for CCL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL8 gene, integrated from 10 sources (see all 200):
    (articles sorted by number of sources associating them with CCL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. (PubMed id 9119400)1, 2, 3, 9 van Coillie E.... Opdenakker G. (Genomics 1997)
    2. Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells. (PubMed id 9070881)1, 2, 9 van Coillie E.... Opdenakker G. (Biochem. Biophys. Res. Commun. 1997)
    3. Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors. (PubMed id 11087354)1, 2, 9 Blaszczyk J.... Ji X. (Biochemistry 2000)
    4. Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP- 2(6-76) as a natural chemokine inhibitor. (PubMed id 9558113)1, 2, 9 Proost P.... Van Damme J. (J. Immunol. 1998)
    5. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)1, 2, 9 van Damme J.... Opdenakker G. (J. Exp. Med. 1992)
    6. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)1, 2, 9 Kim K.-S.... Sykes B.D. (FEBS Lett. 1996)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (Genes Immun. 2010)
    10. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6355 HGNC: 10635 AceView: CCL8 Ensembl:ENSG00000108700 euGenes: HUgn6355
    ECgene: CCL8 Kegg: 6355 H-InvDB: CCL8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL8

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL8 gene:
    Search GeneIP for patents involving CCL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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