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Aliases for CCL8 Gene

Aliases for CCL8 Gene

  • Chemokine (C-C Motif) Ligand 8 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2) 2 3
  • Monocyte Chemoattractant Protein 2 3 4
  • Monocyte Chemotactic Protein 2 3 4
  • Small-Inducible Cytokine A8 3 4
  • SCYA10 3 4

External Ids for CCL8 Gene

Previous HGNC Symbols for CCL8 Gene

  • SCYA8

Previous GeneCards Identifiers for CCL8 Gene

  • GC17P032416
  • GC17P034685
  • GC17P032791
  • GC17P029670
  • GC17P032646
  • GC17P028831

Summaries for CCL8 Gene

Entrez Gene Summary for CCL8 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL8 Gene

CCL8 (Chemokine (C-C Motif) Ligand 8) is a Protein Coding gene. Diseases associated with CCL8 include purulent labyrinthitis and primary syphilis. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include protein kinase activity and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL8 Gene

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.

Gene Wiki entry for CCL8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL8 Gene

Genomics for CCL8 Gene

Regulatory Elements for CCL8 Gene

Genomic Location for CCL8 Gene

Chromosome:
17
Start:
34,319,036 bp from pter
End:
34,321,402 bp from pter
Size:
2,367 bases
Orientation:
Plus strand

Genomic View for CCL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL8 Gene

Proteins for CCL8 Gene

  • Protein details for CCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80075-CCL8_HUMAN
    Recommended name:
    C-C motif chemokine 8
    Protein Accession:
    P80075
    Secondary Accessions:
    • A0AV77
    • P78388

    Protein attributes for CCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11246 Da
    Quaternary structure:
    • Monomer or homodimer; in equilibrium.
    SequenceCaution:
    • Sequence=CAA68168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL8 Gene

neXtProt entry for CCL8 Gene

Proteomics data for CCL8 Gene at MOPED

Post-translational modifications for CCL8 Gene

  • N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CCL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL8 Gene

Domains & Families for CCL8 Gene

Gene Families for CCL8 Gene

Protein Domains for CCL8 Gene

Suggested Antigen Peptide Sequences for CCL8 Gene

Graphical View of Domain Structure for InterPro Entry

P80075

UniProtKB/Swiss-Prot:

CCL8_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL8: view

Function for CCL8 Gene

Molecular function for CCL8 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma, mitogens and IL1/interleukin-1

Gene Ontology (GO) - Molecular Function for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10734056
GO:0008009 chemokine activity IEA --
GO:0008201 heparin binding IEA --
GO:0016004 phospholipase activator activity IDA 10734056
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL8: view
genes like me logo Genes that share phenotypes with CCL8: view

Animal Model Products

miRNA for CCL8 Gene

miRTarBase miRNAs that target CCL8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL8 Gene

Localization for CCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL8 Gene COMPARTMENTS Subcellular localization image for CCL8 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
GO:0005623 cell IDA 10734056
genes like me logo Genes that share ontologies with CCL8: view

Pathways & Interactions for CCL8 Gene

genes like me logo Genes that share pathways with CCL8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006468 protein phosphorylation IDA 10734056
GO:0006816 calcium ion transport IDA 10734056
GO:0006874 cellular calcium ion homeostasis IDA 10734056
genes like me logo Genes that share ontologies with CCL8: view

No data available for SIGNOR curated interactions for CCL8 Gene

Drugs & Compounds for CCL8 Gene

(11) Drugs for CCL8 Gene - From: NovoSeek, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Pyroglutamic acid Experimental Pharma Target 0
Bindarit Pharma 0
CCL3 Pharma Full agonist, Agonist 0

(6) Additional Compounds for CCL8 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Endotoxin
FMLP
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
pyroglutamate
RANTES
genes like me logo Genes that share compounds with CCL8: view

Transcripts for CCL8 Gene

mRNA/cDNA for CCL8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL8 Gene

Chemokine (C-C motif) ligand 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL8 Gene

No ASD Table

Relevant External Links for CCL8 Gene

GeneLoc Exon Structure for
CCL8
ECgene alternative splicing isoforms for
CCL8

Expression for CCL8 Gene

mRNA expression in normal human tissues for CCL8 Gene

mRNA differential expression in normal tissues according to GTEx for CCL8 Gene

This gene is overexpressed in Colon - Transverse (x6.9) and Adipose - Visceral (Omentum) (x5.3).

SOURCE GeneReport for Unigene cluster for CCL8 Gene Hs.271387

mRNA Expression by UniProt/SwissProt for CCL8 Gene

P80075-CCL8_HUMAN
Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate
genes like me logo Genes that share expression patterns with CCL8: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL8 Gene

Orthologs for CCL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCL8 35
  • 81.14 (n)
  • 68.69 (a)
CCL8 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL8 35
  • 79.8 (n)
  • 70.71 (a)
CCL8 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCL8 35
  • 98.99 (n)
  • 98.99 (a)
CCL8 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ccl12 36
  • 57 (a)
OneToMany
Ccl8 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
Species with no ortholog for CCL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL8 Gene

ENSEMBL:
Gene Tree for CCL8 (if available)
TreeFam:
Gene Tree for CCL8 (if available)

Paralogs for CCL8 Gene

Paralogs for CCL8 Gene

genes like me logo Genes that share paralogs with CCL8: view

Variants for CCL8 Gene

Sequence variations from dbSNP and Humsavar for CCL8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1133763 - 34,320,812(+) AGACC(A/C)AACGG reference, missense
rs3138035 -- 34,318,930(+) CTCTG(C/T)AACAG upstream-variant-2KB
rs3138036 -- 34,320,525(+) AGTCC(A/G)TGAGA intron-variant
rs3138037 -- 34,320,725(+) TCAGT(C/T)CTAGG intron-variant
rs11342894 -- 34,321,860(+) ATACC(-/A)GAGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCL8 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Variation tolerance for CCL8 Gene

Residual Variation Intolerance Score: 76.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL8 Gene

HapMap Linkage Disequilibrium report
CCL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL8 Gene

Disorders for CCL8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
purulent labyrinthitis
  • suppurative labyrinthitis
primary syphilis
  • symptomatic early syphilis
diffuse gastric cancer
  • signet cell adenocarcinoma
- elite association
Search CCL8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL8

Genetic Association Database (GAD)
CCL8
Human Genome Epidemiology (HuGE) Navigator
CCL8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL8
genes like me logo Genes that share disorders with CCL8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL8 Gene

Publications for CCL8 Gene

  1. The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2. (PMID: 9119400) van Coillie E. … Opdenakker G. (Genomics 1997) 2 23 67
  2. Ex vivo TCR-induced leukocyte gene expression of inflammatory mediators is increased in type 1 diabetic patients but not in overweight children. (PMID: 19943328) Rosa J.S. … Galassetti P.R. (Diabetes Metab. Res. Rev. 2010) 23 67
  3. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. (PMID: 19160404) Ebbens F.A. … Fokkens W.J. (Laryngoscope 2009) 23 67
  4. IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay. (PMID: 19193208) Ruhwald M. … Ravn P. (BMC Res Notes 2009) 23 67
  5. A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins. (PMID: 19034645) Cochran S. … Ferro V. (Glycoconj. J. 2009) 23 67

Products for CCL8 Gene

Sources for CCL8 Gene

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