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Aliases for CCL7 Gene

Aliases for CCL7 Gene

  • Chemokine (C-C Motif) Ligand 7 2 3
  • Monocyte Chemoattractant Protein 3 2 3 4
  • Monocyte Chemotactic Protein 3 2 3 4
  • SCYA7 3 4 6
  • MCP3 3 4 6
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3) 2 3
  • Small-Inducible Cytokine A7 3 4
  • SCYA6 3 4
  • MCP-3 3 4
  • NC28 3 4
  • C-C Motif Chemokine 7 3
  • MARC 3
  • FIC 3

External Ids for CCL7 Gene

Previous Symbols for CCL7 Gene

  • SCYA6
  • SCYA7

Summaries for CCL7 Gene

Entrez Gene Summary for CCL7 Gene

  • This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL7 Gene

CCL7 (Chemokine (C-C Motif) Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include demyelinating disease and nephrogenic systemic fibrosis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL7 Gene

  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3

Gene Wiki entry for CCL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL7 Gene

Genomics for CCL7 Gene

Genomic Location for CCL7 Gene

Start:
34,270,216 bp from pter
End:
34,272,242 bp from pter
Size:
2,027 bases
Orientation:
Plus strand

Genomic View for CCL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL7 Gene

Regulatory Elements for CCL7 Gene

Proteins for CCL7 Gene

  • Protein details for CCL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80098-CCL7_HUMAN
    Recommended name:
    C-C motif chemokine 7
    Protein Accession:
    P80098
    Secondary Accessions:
    • Q569J6

    Protein attributes for CCL7 Gene

    Size:
    99 amino acids
    Molecular mass:
    11200 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAA50405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA50406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL7 Gene

neXtProt entry for CCL7 Gene

Proteomics data for CCL7 Gene at MOPED

Post-translational modifications for CCL7 Gene

Other Protein References for CCL7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL7 Gene

Domains for CCL7 Gene

Gene Families for CCL7 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL7 Gene

Suggested Antigen Peptide Sequences for CCL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80098

UniProtKB/Swiss-Prot:

CCL7_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • P80098
genes like me logo Genes that share domains with CCL7: view

Function for CCL7 Gene

Molecular function for CCL7 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3

Gene Ontology (GO) - Molecular Function for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IDA 10072545
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 10660125
GO:0031727 CCR2 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with CCL7: view

Phenotypes for CCL7 Gene

genes like me logo Genes that share phenotypes with CCL7: view

Animal Models for CCL7 Gene

MGI Knock Outs for CCL7:

miRNA for CCL7 Gene

miRTarBase miRNAs that target CCL7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCL7 Gene

Localization for CCL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL7 Gene COMPARTMENTS Subcellular localization image for CCL7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL7: view

Pathways for CCL7 Gene

genes like me logo Genes that share pathways with CCL7: view

Gene Ontology (GO) - Biological Process for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 10770925
GO:0006935 chemotaxis TAS 9780207
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL7: view

Compounds for CCL7 Gene

(29) Novoseek inferred chemical compound relationships for CCL7 Gene

Compound -log(P) Hits PubMed IDs
rantes 94.4 200
mcp 3 79.2 19
ccl3 69 5
tarc 68.7 5
groalpha 65.3 1
genes like me logo Genes that share compounds with CCL7: view

Transcripts for CCL7 Gene

mRNA/cDNA for CCL7 Gene

Unigene Clusters for CCL7 Gene

Chemokine (C-C motif) ligand 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -

Relevant External Links for CCL7 Gene

GeneLoc Exon Structure for
CCL7
ECgene alternative splicing isoforms for
CCL7

Expression for CCL7 Gene

mRNA expression in normal human tissues for CCL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL7 Gene

This gene is overexpressed in Brain - Substantia nigra (5.6) and Lung (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCL7 Gene

SOURCE GeneReport for Unigene cluster for CCL7 Gene Hs.251526

genes like me logo Genes that share expressions with CCL7: view

No data available for mRNA Expression by UniProt/SwissProt for CCL7 Gene

Orthologs for CCL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL7 35
  • 99.33 (n)
  • 98.99 (a)
CCL7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL7 35
  • 82.83 (n)
  • 77.78 (a)
CCL7 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl7 16
Ccl7 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
Species with no ortholog for CCL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL7 Gene

ENSEMBL:
Gene Tree for CCL7 (if available)
TreeFam:
Gene Tree for CCL7 (if available)

Paralogs for CCL7 Gene

Paralogs for CCL7 Gene

genes like me logo Genes that share paralogs with CCL7: view

Variants for CCL7 Gene

Sequence variations from dbSNP and Humsavar for CCL7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2286439 -- 34,272,341(-) CCACA(A/G)TGTGA downstream-variant-500B
rs2302160 -- 34,271,274(-) GTCAT(C/T)GTCCA intron-variant
rs3091237 -- 34,270,784(+) CGTAT(C/T)AGGGA intron-variant
rs3091318 -- 34,268,909(+) CCCCA(C/T)TGAAT upstream-variant-2KB
rs3091319 -- 34,269,882(+) GGATA(A/C)CACTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL7 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Relevant External Links for CCL7 Gene

HapMap Linkage Disequilibrium report
CCL7
Human Gene Mutation Database (HGMD)
CCL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL7 Gene

Disorders for CCL7 Gene

(2) University of Copenhagen DISEASES for CCL7 Gene

(34) Novoseek inferred disease relationships for CCL7 Gene

Disease -log(P) Hits PubMed IDs
inflammation 59.4 11
asthma allergic 43 1
nasal polyps 37.2 1
asthma 35.7 8
eosinophilia 29.3 1

Relevant External Links for CCL7

Genetic Association Database (GAD)
CCL7
Human Genome Epidemiology (HuGE) Navigator
CCL7
genes like me logo Genes that share disorders with CCL7: view

No data available for UniProtKB/Swiss-Prot for CCL7 Gene

Publications for CCL7 Gene

  1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PMID: 8461011) Opdenakker G. … van Damme J. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23
  2. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PMID: 8898111) Kim K.-S. … Sykes B.D. (FEBS Lett. 1996) 3 4 23
  3. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PMID: 1613466) van Damme J. … Opdenakker G. (J. Exp. Med. 1992) 3 4 23
  4. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2- q12. (PMID: 7916328) Opdenakker G. … van Damme J. (Genomics 1994) 3 4 23
  5. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PMID: 9109648) Meunier S. … Darbon H. (Biochemistry 1997) 3 4 23

Products for CCL7 Gene

Sources for CCL7 Gene

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