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CCL7 Gene

protein-coding   GIFtS: 65
GCID: GC17P032597

Chemokine (C-C Motif) Ligand 7

(Previous name: small inducible cytokine A7 (monocyte chemotactic protein...)
(Previous symbols: SCYA6, SCYA7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 71 2     Small-Inducible Cytokine A72 3
SCYA71 2 3 5     MCP-32 3
SCYA61 2 3     NC282 3
Monocyte Chemoattractant Protein 31 2 3     FIC2
Monocyte Chemotactic Protein 31 2 3     MARC2
MCP32 3 5     C-C Motif Chemokine 72
Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3)1 2     

External Ids:    HGNC: 106341   Entrez Gene: 63542   Ensembl: ENSG000001086887   OMIM: 1581065   UniProtKB: P800983   

Export aliases for CCL7 gene to outside databases

Previous GC identifers: GC17P032366 GC17P034636 GC17P032742 GC17P029621 GC17P028782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL7 Gene:
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during
inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having
two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme
which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family
members on chromosome 17q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL7 Gene:
CCL7 (chemokine (C-C motif) ligand 7) is a protein-coding gene. Diseases associated with CCL7 include stachybotrys chartarum, and usual interstitial pneumonia. GO annotations related to this gene include CCR1 chemokine receptor binding and heparin binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098
Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte
anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2
and CCR3

Gene Wiki entry for CCL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL7 gene promoter:
         c-Fos   STAT1   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL7 promoter sequence
   Search Chromatin IP Primers for CCL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

CCL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032597:  view genomic region     (about GC identifiers)

Start:
32,597,240 bp from pter      End:
32,599,261 bp from pter
Size:
2,022 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098 (See protein sequence)
Recommended Name: C-C motif chemokine 7 precursor  
Size: 99 amino acids; 11200 Da
Subunit: Monomer
Sequence caution: Sequence=CAA50405.1; Type=Erroneous initiation; Sequence=CAA50406.1; Type=Erroneous initiation;
Sequence=CAA51055.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CCL7:
1BO0 (3D)        1NCV (3D)    
Secondary accessions: Q569J6

Explore the universe of human proteins at neXtProt for CCL7: NX_P80098

Explore proteomics data for CCL7 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Asn29

  • See CCL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006264.2  
    ENSEMBL proteins: 
     ENSP00000367832   ENSP00000378124   ENSP00000378126   ENSP00000200307  
    Reactome Protein details: P80098

    CCL7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL7
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL7
    GenScript Purified and Recombinant Proteins for CCL7
    Novus Biologicals CCL7 Proteins
    Sino Biological Recombinant Protein for CCL7
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL7
    Browse Proteins at Cloud-Clone Corp.

    CCL7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL7 (CCL7/MCP-3/MARC)
    Browse OriGene Antibodies
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    Novus Biologicals CCL7 Antibodies
    Abcam antibodies for CCL7
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL7
    LSBio Antibodies in human, mouse, rat for CCL7

    CCL7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL7 (CCL7/MCP-3/MARC)         (see all)
    GenScript Custom Assay Services for CCL7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P80098

    ProtoNet protein and cluster: P80098

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL7_HUMAN, P80098
    Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte
    anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2
    and CCR3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA10072545
    GO:0008201heparin binding IEA--
    GO:0031726CCR1 chemokine receptor binding IPI10660125
    GO:0031727CCR2 chemokine receptor binding IEA--
         
    CCL7 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl7):
     hematopoietic system  immune system 

    CCL7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl7tm1Ifc for CCL7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL7:
    hsa-mir-26b-5p (MIRT029409)

    Block miRNA regulation of human, mouse, rat CCL7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL7 (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCCL7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL7
    Predesigned siRNA for gene silencing in human, mouse, rat CCL7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL7

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL7 (see all 5)
    OriGene ORF clones in mouse, rat for CCL7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL7 (NM_006273)
    Sino Biological Human cDNA Clone for CCL7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL7_HUMAN, P80098: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL7 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL7
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL7 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL7
        Immune response CCR3 signaling in eosinophils


    1 Reactome Pathway for CCL7
        Chemokine receptors bind chemokines


    2 Kegg Pathways  (Kegg details for CCL7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL7 (see all 15): 
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL7 (P800982, 3 ENSP000002003074) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AESQ081172, 3, ENSP000002215614MINT-64064 I2D: score=3 STRING: ENSP00000221561
    FEZ1Q996892, 3, ENSP000002789194MINT-64011 I2D: score=5 STRING: ENSP00000278919
    ACKR2O005903, ENSP000002731454I2D: score=4 STRING: ENSP00000273145
    CCR3P516773, ENSP000003500034I2D: score=3 STRING: ENSP00000350003
    MMP2P082533, ENSP000002190704I2D: score=3 STRING: ENSP00000219070
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002548monocyte chemotaxis IC10660125
    GO:0006874cellular calcium ion homeostasis TAS10770925
    GO:0006935chemotaxis TAS9780207
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--

    CCL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL7

    Selected Novoseek inferred chemical compound relationships for CCL7 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 94.4 309 7507512 (10), 9311806 (8), 9394815 (7), 11090473 (5) (see all 99)
    mcp 3 79.2 41 7589134 (10), 7545673 (9)
    ccl3 69 8 12851650 (1), 15818740 (1), 17178797 (1), 16197470 (1) (see all 5)
    tarc 68.7 7 9153236 (1), 9430724 (1), 10372118 (1), 11964742 (1) (see all 5)
    groalpha 65.3 1 10737895 (1)
    larc 63 4 9153236 (1), 10449163 (1), 11792124 (1)
    teck 59.3 1 10449163 (1)
    mcp 1 56.9 6 7589134 (3), 7545673 (2)
    anaphylatoxin 43.6 2 8855287 (1)
    calcium 36.7 24 8144937 (3), 7759884 (2), 10733106 (1), 9060459 (1) (see all 14)



    CCL7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCL7 gene: 
    NM_006273.3  

    Unigene Cluster for CCL7:

    Chemokine (C-C motif) ligand 7
    Hs.251526  [show with all ESTs]
    Unigene Representative Sequence: CD521885
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378569(uc002hhz.3 uc010ctf.3) ENST00000394627 ENST00000394630
    ENST00000200307
    miRNA
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    Block miRNA regulation of human, mouse, rat CCL7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL7 (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCCL7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCL7
    Predesigned siRNA for gene silencing in human, mouse, rat CCL7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL7 (NM_006273)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL7
      QuantiTect SYBR Green Assays in human, mouse, rat CCL7
      QuantiFast Probe-based Assays in human, mouse, rat CCL7

    Additional mRNA sequence: 

    AF043338.1 BC070240.1 BC092436.1 BC112258.1 BC112260.1 X71087.1 

    1 DOTS entry:

    DT.65286829 

    Selected AceView cDNA sequences (see all 70):

    CA306760 X72308 AA127067 BC017850 BF197516 AW294260 NM_002986 CD520379 
    CA843078 CR457421 AI537716 CD522731 U46573 BX108913 AI357416 AA910483 
    AW197514 AI913625 BU752454 CA843831 CD640376 CD523198 NM_006273 X71087 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for CCL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTATTGT
    CCL7 Expression
    About this image


    CCL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CCL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.251526
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL7 (see all 15): 
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL7
    QuantiTect SYBR Green Assays in human, mouse, rat CCL7
    QuantiFast Probe-based Assays in human, mouse, rat CCL7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL7 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl75 chemokine (C-C motif) ligand 7   --   11 (49.83 cM) 82045712 


    ENSEMBL Gene Tree for CCL7 (if available)
    TreeFam Gene Tree for CCL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL7 gene
    CCL112  CCL132  CCL82  CCL22  CCL242  
    Selected SIMAP similar genes for CCL7 using alignment to 3 protein entries:     CCL7_HUMAN (see all proteins) (see all similar genes):
    MCP-3    CCL11    CCL2    CCL8    CCL13    CCL3
    CCL3L1    CCL3L3    CCL4    CCL4L2    LOC728835    CCL14
    CCL4L1    CCL16    CX3CL1    CCL5    CCL18    CCL22

    CCL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CCL7 (see all 151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819878851,2
    --32595520(+) CCCCCA/GTGTTC 1 -- us2k10--------
    rs177357051,2
    C,F--32595535(+) CCAACT/GTCATC 1 -- us2k14Minor allele frequency- G:0.01NA 262
    rs1142773501,2
    C,F--32595545(+) CGATCA/CTTCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1857501271,2
    --32595603(+) AGAAAG/TAAAAG 1 -- us2k10--------
    rs362318381,2
    C--32595689(-) TAACAC/TATTAG 1 -- us2k10--------
    rs362318371,2
    C,F--32595800(-) TCTCGA/TTTATC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1511728071,2
    --32595801(+) ATAATA/CGAGAG 1 -- us2k10--------
    rs362318361,2
    C,F--32595830(-) CCCCTA/GTGACT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1402724071,2
    --32595850(+) ACGACA/TTAAAG 1 -- us2k10--------
    rs1440980981,2
    --32595856(+) TAAAGC/GTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL7 (32597240 - 32599261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CCL7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 158106    OMIM disorders: --

    Selected diseases for CCL7 (see all 64):    
    About MalaCards
    stachybotrys chartarum    usual interstitial pneumonia    b cell deficiency    t cell deficiency
    intrinsic asthma    vernal keratoconjunctivitis    pulmonary eosinophilia    nephrogenic systemic fibrosis
    eosinophilia    chorioamnionitis    rhinitis    cholera
    allergic rhinitis    neurofibromatosis    cerebral palsy    bronchopulmonary dysplasia
    keratoconjunctivitis    pneumonia    cytomegalovirus infection    cystitis

    2 diseases from the University of Copenhagen DISEASES database for CCL7:
    Asthma     Eosinophilia

    CCL7 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCL7 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 59.4 18 10205198 (2), 15901268 (2), 15715950 (1), 15103673 (1) (see all 9)
    asthma allergic 43 1 8980953 (1)
    nasal polyps 37.2 1 9532637 (1)
    asthma 35.7 10 15715950 (3), 18579545 (1), 8998072 (1), 10902138 (1) (see all 6)
    eosinophilia 29.3 1 10491000 (1)
    allergic rhinitis 27.6 4 10359883 (1), 11150001 (1), 17982926 (1), 12028117 (1)
    necrosis 27.4 6 8833040 (1), 10205198 (1), 14755722 (1), 19131226 (1) (see all 6)
    sclerosis systemic 23.2 6 12847692 (2), 16344498 (1), 16641048 (1)
    tumors 22.9 23 18533557 (5), 11529662 (2), 19424580 (2), 12393570 (1) (see all 13)
    allergy 19.2 2 9800627 (1), 10640766 (1)

    Genetic Association Database (GAD): CCL7
    Human Genome Epidemiology (HuGE) Navigator: CCL7 (19 documents)

    Export disorders for CCL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL7 gene, integrated from 10 sources (see all 352):
    (articles sorted by number of sources associating them with CCL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PubMed id 8461011)1, 2, 3, 9 Opdenakker G.... van Damme J. (Biochem. Biophys. Res. Commun. 1993)
    2. Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. (PubMed id 8318676)1, 2, 9 Minty A.... Caput D. (Eur. Cytokine Netw. 1993)
    3. Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PubMed id 15715950)1, 4, 9 Park B.L....Shin H.D. (J. Biochem. Mol. Biol. 2005)
    4. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2- q12. (PubMed id 7916328)1, 2, 9 Opdenakker G.... van Damme J. (Genomics 1994)
    5. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)1, 2, 9 Kim K.-S.... Sykes B.D. (FEBS Lett. 1996)
    6. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)1, 2, 9 van Damme J.... Opdenakker G. (J. Exp. Med. 1992)
    7. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PubMed id 9109648)1, 2, 9 Meunier S.... Darbon H. (Biochemistry 1997)
    8. MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. (PubMed id 14571188)1, 4, 9 Modi W.S....Winkler C. (AIDS 2003)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6354 HGNC: 10634 AceView: CCL11andCCL7 Ensembl:ENSG00000108688 euGenes: HUgn6354
    ECgene: CCL7 Kegg: 6354 H-InvDB: CCL7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL7 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL7 gene:
    Search GeneIP for patents involving CCL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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