Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL7 Gene

protein-coding GIFtS: 62
GCID: GC17P032597

chemokine (C-C motif) ligand 7

(Previous name: small inducible cytokine A7 (monocyte chemotactic protein...)
(Previous symbols: SCYA6, SCYA7)

Explore 64 diseases affiliated with
CCL7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 7¹ ²		MARC¹ ²
MCP3¹ ² ³ ⁵		Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3)¹ ²
SCYA7¹ ² ³ ⁵		Monocyte Chemoattractant Protein 3² ³
MCP-3¹ ² ³		Monocyte Chemotactic Protein 3² ³
NC28¹ ² ³		Small-Inducible Cytokine A7² ³
SCYA6¹ ² ³		C-C Motif Chemokine 7²
FIC¹ ²

External Ids:	HGNC: 10634¹	Entrez Gene: 6354²	Ensembl: ENSG00000108688⁷	OMIM: 158106⁵	UniProtKB: P80098³

Export aliases for CCL7 gene to outside databases

Previous GC identifers: GC17P032366 GC17P034636 GC17P032742 GC17P029621 GC17P028782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL7:

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation

and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent

cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades

components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome

17q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098

Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor

activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3

Gene Wiki entry for CCL7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL7 gene promoter:
c-Fos STAT1 AP-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL7 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12

CCL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL7 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P032597: view genomic region (about GC identifiers)

Start:	32,597,240 bp from pter	End:	32,599,261 bp from pter
Size:	2,022 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098 (See protein sequence)

Recommended Name: C-C motif chemokine 7 precursor

Size: 99 amino acids; 11200 Da

Subunit: Monomer

Subcellular location: Secreted

Sequence caution: Sequence=CAA50405.1; Type=Erroneous initiation; Sequence=CAA50406.1; Type=Erroneous initiation;

Sequence=CAA51055.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for CCL7:

1BO0 (3D)

1NCV (3D)

Secondary accessions: Q569J6

Explore the universe of human proteins at neXtProt for CCL7: NX_P80098

Post-translational modifications:

O-glycosylated¹

View neXtProt modification sites for NX_P80098

CCL7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006264.2

ENSEMBL proteins:

ENSP00000367832 ENSP00000378124 ENSP00000378126 ENSP00000200307

Reactome Protein details: P80098
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL7 (CCL7/MCP-3/MARC)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CCL7
	GenScript Purified and Recombinant Proteins for CCL7
	Novus Biologicals CCL7 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL7
	Uscn Proteins for CCL7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL7 for ontologies About GeneDecksing

CCL7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL7 (CCL7/MCP-3/MARC)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CCL7
	GenScript Custom Superior Antibodies Services for CCL7
	Novus Biologicals CCL7 Antibodies
	Search for Antibodies for CCL7 at Abcam
	Uscn Antibodies for CCL7
	ThermoFisher Antibodies for CCL7

Assay Products for CCL7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CCL7 (CCL7/MCP-3/MARC) (see all)
	GenScript Custom Assay Services for CCL7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL7 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P80098

ProtoNet protein and cluster: P80098

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098

Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor

activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL7
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL7 (see all 14):
		hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: CCL7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL7 (see all 7) OriGene shRNA RFP: CCL7 OriGene siRNA: CCL7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL7 (NM_006273)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL7
		Search LifeMap BioReagents cell lines for CCL7

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL7

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IDA	10072545
GO:0008201	heparin binding	IEA	--
GO:0031726	CCR1 chemokine receptor binding	IPI	10660125
GO:0031727	CCR2 chemokine receptor binding	IEA	--

CCL7 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ccl7^tm1Ifc for CCL7
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccl7):

hematopoietic system

immune system

CCL7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCL7

Immune response CCR3 signaling in eosinophils

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL7 (see all 28)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 GeneGo (Thomson Reuters) Pathway for CCL7

Immune response CCR3 signaling in eosinophils

5/6 Reactome Pathways for CCL7 (see all 6)

	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding

2 Kegg Pathways (Kegg details for CCL7):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCL7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for CCL7 (P80098^{2, 3} ENSP00000200307⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AES	Q08117²^,³, ENSP00000221561⁴	MINT-64064 I2D: score=3 STRING: ENSP00000221561
FEZ1	Q99689²^,³, ENSP00000278919⁴	MINT-64011 I2D: score=5 STRING: ENSP00000278919
CCBP2	O00590³, ENSP00000273145⁴	I2D: score=4 STRING: ENSP00000273145
CCR3	P51677³, ENSP00000350003⁴	I2D: score=3 STRING: ENSP00000350003
MMP2	P08253³, ENSP00000219070⁴	I2D: score=3 STRING: ENSP00000219070

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002548	monocyte chemotaxis	IC	10660125
GO:0006874	cellular calcium ion homeostasis	TAS	10770925
GO:0006935	chemotaxis	TAS	9780207
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--

CCL7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL7
10/29 Novoseek chemical compound relationships for CCL7 gene (see all 29) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	94.4	309	7507512 (10), 9311806 (8), 9394815 (7), 11090473 (5) (see all 99)
mcp 3	79.2	41	7589134 (10), 7545673 (9)
ccl3	69	8	12851650 (1), 15818740 (1), 17178797 (1), 16197470 (1) (see all 5)
tarc	68.7	7	9153236 (1), 9430724 (1), 10372118 (1), 11964742 (1) (see all 5)
groalpha	65.3	1	10737895 (1)
larc	63	4	9153236 (1), 10449163 (1), 11792124 (1)
teck	59.3	1	10449163 (1)
mcp 1	56.9	6	7589134 (3), 7545673 (2)
anaphylatoxin	43.6	2	8855287 (1)
calcium	36.7	24	8144937 (3), 7759884 (2), 10733106 (1), 9060459 (1) (see all 14)

Search CenterWatch for drugs/clinical trials and news about CCL7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL7 gene:

NM_006273.3

Unigene Cluster for CCL7:

Chemokine (C-C motif) ligand 7

Hs.251526 [show with all ESTs]

Unigene Representative Sequence: CD521885

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378569(uc002hhz.3 uc010ctf.3) ENST00000394627 ENST00000394630

ENST00000200307

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL7
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL7 (see all 14):
		hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: CCL7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL7 (see all 7) OriGene shRNA RFP: CCL7 OriGene siRNA: CCL7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL7 (NM_006273)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL7

Additional cDNA sequence:

AF043338.1 BC070240.1 BC092436.1 BC112258.1 BC112260.1 X71087.1

1 DOTS entry:

DT.65286829

24/70 AceView cDNA sequences (see all 70):

BC017850 BF197516 NM_002986 AA127067 X72308 AW294260 CA306760 CD640376

CR457421 AI913629 W69315 BU752454 BX108913 CD522731 CD642089 CD641807

CD521785 BF594486 CD641059 W69211 CD520085 CD638789 BU752524 CA843831

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL7 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c
SP1:					-
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for CCL7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGTATTGT

About this image
See CCL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL7

SOURCE GeneReport for Unigene cluster: Hs.251526

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL7 (see all 15):

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

Inflammasomes in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Tumor Metastasis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL7

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL7 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:dkeyp-59a8.2⁶ si:dkeyp-59a8.3⁶ (see all 6)	si:dkeyp-59a8.3 (see all 6)	33(a) 32(a) (see all 6)	many ↔ many many ↔ many (see all 6)	20(38304232-38305101) 20(38310380-38311158)

ENSEMBL Gene Tree for CCL7 (if available)
TreeFam Gene Tree for CCL7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL7 gene

CCL15² CCL16² CCL2² CCL14² CCL24² CCL4L1² CCL11² CCL4L2²

CCL3L1² CCL5² CCL23² CCL3L3² CCL4² CCL8² CCL13² CCL26²

CCL3² CCL18²

18/29 SIMAP similar genes for CCL7 using alignment to 3 protein entries: CCL7_HUMAN (see all proteins) (see all similar genes):

MCP-3 CCL11 CCL2 CCL8 CCL13 CCL3

CCL3L1 CCL3L3 CCL4 CCL4L2 LOC728835 CCL14

CCL4L1 CCL16 CX3CL1 CCL5 CCL18 CCL22

CCL7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181987885^1,2		--	32595520(+)	`CCCCCA/GTGTTC`	1	--	us2k¹		0	--	--	--	--
rs17735705^1,2	C,	--	32595535(+)	`CCAACT/GTCATC`	1	--	us2k¹		4		NA	262
rs114277350^1,2	F,	--	32595545(+)	`CGATCA/CTTCAG`	1	--	us2k¹		1		WA	118
rs185750127^1,2		--	32595603(+)	`AGAAAG/TAAAAG`	1	--	us2k¹		0	--	--	--	--
rs36231838^1,2	C,	--	32595689(-)	`TAACAC/TATTAG`	1	--	us2k¹		0	--	--	--	--
rs36231837^1,2	C,F,	--	32595800(-)	`TCTCGA/TTTATC`	1	--	us2k¹		1		WA	118
rs151172807^1,2		--	32595801(+)	`ATAATA/CGAGAG`	1	--	us2k¹		0	--	--	--	--
rs36231836^1,2	C,	--	32595830(-)	`CCCCTA/GTGACT`	1	--	us2k¹		1		NA	120
rs140272407^1,2		--	32595850(+)	`ACGACA/TTAAAG`	1	--	us2k¹		0	--	--	--	--
rs144098098^1,2		--	32595856(+)	`TAAAGC/GTAAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL7 (32597240 - 32599261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCL7: --
Human Gene Mutation Database (HGMD): CCL7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL7

DNA2.0 Custom Variant and Variant Library Synthesis for CCL7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL7 for disorders           About GeneDecksing

OMIM gene information: 158106    OMIM disorders: --

20/64 diseases for CCL7 (see all 64):    About MalaCards

stachybotrys chartarum usual interstitial pneumonia vernal keratoconjunctivitis allergic rhinitis

familial adenomatous polyposis inflammatory bowel disease intrinsic asthma b-cell lymphomas

ankylosing spondylitis oral squamous cell carcinoma bronchopulmonary dysplasia eosinophilia

rhinitis keratoconjunctivitis squamous cell carcinoma cytomegalovirus infection

pulmonary eosinophilia atopic dermatitis b cell deficiency multiple sclerosis

1 disease from the University of Copenhagen DISEASES database for CCL7:

Asthma

10/34 Novoseek disease relationships for CCL7 gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	59.4	18	10205198 (2), 15901268 (2), 15715950 (1), 15103673 (1) (see all 9)
asthma allergic	43	1	8980953 (1)
nasal polyps	37.2	1	9532637 (1)
asthma	35.7	10	15715950 (3), 18579545 (1), 8998072 (1), 10902138 (1) (see all 6)
eosinophilia	29.3	1	10491000 (1)
allergic rhinitis	27.6	4	10359883 (1), 11150001 (1), 17982926 (1), 12028117 (1)
necrosis	27.4	6	8833040 (1), 10205198 (1), 14755722 (1), 19131226 (1) (see all 6)
sclerosis systemic	23.2	6	12847692 (2), 16344498 (1), 16641048 (1)
tumors	22.9	23	18533557 (5), 11529662 (2), 19424580 (2), 12393570 (1) (see all 13)
allergy	19.2	2	9800627 (1), 10640766 (1)

Genetic Association Database (GAD): CCL7
Human Genome Epidemiology (HuGE) Navigator: CCL7 (19 documents)

Export disorders for CCL7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL7 gene, integrated from 9 sources (see all 350):
(articles sorted by number of sources associating them with CCL7)

Utopia: connect your pdf to the dynamic
world of online information

Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PubMed id 8461011)^{1, 2, 3, 9} Opdenakker G.... van Damme J. (1993)
Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. (PubMed id 8318676)^{1, 2, 9} Minty A.... Caput D. (1993)
Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PubMed id 15715950)^{1, 4, 9} Park B.L....Shin H.D. (2005)
The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2- q12. (PubMed id 7916328)^{1, 2, 9} Opdenakker G.... van Damme J. (1994)
Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)^{1, 2, 9} Kim K.-S.... Sykes B.D. (1996)
Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)^{1, 2, 9} van Damme J.... Opdenakker G. (1992)
Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PubMed id 9109648)^{1, 2, 9} Meunier S.... Darbon H. (1997)
MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. (PubMed id 14571188)^{1, 4, 9} Modi W.S....Winkler C. (2003)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6354	HGNC: 10634	AceView: CCL11andCCL7	Ensembl:ENSG00000108688	euGenes: HUgn6354
ECgene: CCL7	Kegg: 6354	H-InvDB: CCL7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCL7	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CCL7

Intellectual Property for CCL7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCL7 gene:
Search GeneIP for patents involving CCL7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CCL7 (CCL7/MCP-3/MARC)		Browse Cell Culture Products
	ELISAs for CCL7 (CCL7/MCP-3/MARC)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for CCL7 (CCL7/MCP-3/MARC)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CCL7 (CCL7/MCP-3/MARC)

	Browse OriGene Antibodies		OriGene shRNA RFP for CCL7
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL7
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CCL7		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CCL7		OriGene Custom Protein Services for CCL7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL7

	GenScript Purified and Recombinant Proteins for CCL7		GenScript cDNA clones with any tag delivered in your preferred vector for CCL7
	GenScript Custom Assay Services for CCL7		GenScript Custom Superior Antibodies Services for CCL7
	GenScript Custom overexpressing Cell Line Services for CCL7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CCL7 promoter
	Search Chromatin IP Primers for CCL7
	RT² qPCR Primer Assay in human, mouse, rat CCL7
	GNC Network for CCL7
	SABiosciences PCR Arrays including human, mouse, rat CCL7

Search Tocris compounds for CCL7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CCL7 antibodies
	CCL7 proteins

	Search for Antibodies for CCL7 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CCL7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CCL7

CCL7 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CCL7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL7

	SwitchGear 3'UTR luciferase reporter plasmids for CCL7
	SwitchGear Promoter luciferase reporter plasmids for CCL7

ThermoFisher Antibodies for CCL7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCL7 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CCL7 Gene

chemokine (C-C motif) ligand 7

Aliases
for CCL7 gene

Summaries
for CCL7 gene

Genomic Views
for CCL7 gene

Proteins
for CCL7 gene

Protein Domains /
Families
for CCL7 gene

Function
for CCL7 gene

Pathways & Interactions
for CCL7 gene

Drugs & Compounds
for CCL7 gene

Transcripts
for CCL7 gene

Expression
for CCL7 gene

Orthologs
for CCL7 gene

Paralogs
for CCL7 gene

Genomic Variants
for CCL7 gene

Disorders / Diseases
for CCL7 gene

Publications
for CCL7 gene

External Searches for CCL7 gene

Genome Databases showing CCL7 gene

Other Databases showing CCL7 gene

Specialized Databases showing CCL7 gene

Intellectual Property
for CCL7 gene

Products
for CCL7 gene

View Random Gene

Melanoma
Encephalomyelitis
atherosclerotic plaque
Dermatitis Atopic
Colitis Ulcerative
Allergic Reaction
allergy
Leukemia
Osteosarcoma
Asthma
CERVICAL CARCINOMA
Allergic rhinitis
Cancer
Inflammatory Bowel Diseases
Lymphoma
Nasal Polyps
Lymphoma B-Cell
HIV Infections
Eosinophilia
Multiple Sclerosis
Inflammation
Tuberculosis
Lung diseases
immunodeficiency
Neurofibromatosis Type 1
Pneumonia
Tumors
Metastasis
Rhinitis
Necrosis
Cholera
Asthma allergic
Sclerosis Systemic
virus infection

Advanced Search

Export list of displayed genes

CCL7 Gene

chemokine (C-C motif) ligand 7

Aliasesfor CCL7 gene

Summariesfor CCL7 gene

Genomic Viewsfor CCL7 gene

Proteinsfor CCL7 gene

Protein Domains /Familiesfor CCL7 gene

Functionfor CCL7 gene

Pathways & Interactionsfor CCL7 gene

Drugs & Compoundsfor CCL7 gene

Transcriptsfor CCL7 gene

Expression for CCL7 gene

Orthologsfor CCL7 gene

Paralogsfor CCL7 gene

Genomic Variantsfor CCL7 gene

Disorders / Diseasesfor CCL7 gene

Publicationsfor CCL7 gene

External Searches for CCL7 gene

Genome Databases showing CCL7 gene

Other Databases showing CCL7 gene

Specialized Databases showing CCL7 gene

Intellectual Propertyfor CCL7 gene

Productsfor CCL7 gene

View Random Gene

Aliases
for CCL7 gene

Summaries
for CCL7 gene

Genomic Views
for CCL7 gene

Proteins
for CCL7 gene

Protein Domains /
Families
for CCL7 gene

Function
for CCL7 gene

Pathways & Interactions
for CCL7 gene

Drugs & Compounds
for CCL7 gene

Transcripts
for CCL7 gene

Expression
for CCL7 gene

Orthologs
for CCL7 gene

Paralogs
for CCL7 gene

Genomic Variants
for CCL7 gene

Disorders / Diseases
for CCL7 gene

Publications
for CCL7 gene

Intellectual Property
for CCL7 gene

Products
for CCL7 gene