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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL7 Gene

protein-coding   GIFtS: 64
GCID: GC17P032597

Chemokine (C-C Motif) Ligand 7

(Previous name: small inducible cytokine A7 (monocyte chemotactic protein...)
(Previous symbols: SCYA6, SCYA7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 71 2     Small-Inducible Cytokine A72 3
SCYA71 2 3 5     MCP-32 3
SCYA61 2 3     NC282 3
Monocyte Chemoattractant Protein 31 2 3     FIC2
Monocyte Chemotactic Protein 31 2 3     MARC2
MCP32 3 5     C-C Motif Chemokine 72
Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3)1 2     

External Ids:    HGNC: 106341   Entrez Gene: 63542   Ensembl: ENSG000001086887   OMIM: 1581065   UniProtKB: P800983   

Export aliases for CCL7 gene to outside databases

Previous GC identifers: GC17P032366 GC17P034636 GC17P032742 GC17P029621 GC17P028782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL7 Gene:
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during
inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having
two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme
which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family
members on chromosome 17q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL7 Gene: 
CCL7 (chemokine (C-C motif) ligand 7) is a protein-coding gene. Diseases associated with CCL7 include usual interstitial pneumonia, and stachybotrys chartarum, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include CCR1 chemokine receptor binding and heparin binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098
Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte
anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2
and CCR3

Gene Wiki entry for CCL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL7 gene promoter:
         c-Fos   STAT1   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

CCL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032597:  view genomic region     (about GC identifiers)

Start:
32,597,240 bp from pter      End:
32,599,261 bp from pter
Size:
2,022 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098 (See protein sequence)
Recommended Name: C-C motif chemokine 7 precursor  
Size: 99 amino acids; 11200 Da
Subunit: Monomer
Subcellular location: Secreted
Sequence caution: Sequence=CAA50405.1; Type=Erroneous initiation; Sequence=CAA50406.1; Type=Erroneous initiation;
Sequence=CAA51055.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CCL7:
1BO0 (3D)        1NCV (3D)    
Secondary accessions: Q569J6

Explore the universe of human proteins at neXtProt for CCL7: NX_P80098

Explore proteomics data for CCL7 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated
  • View neXtProt modification sites for NX_P80098

  • CCL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL7 Protein Expression
    REFSEQ proteins: NP_006264.2  
    ENSEMBL proteins: 
     ENSP00000367832   ENSP00000378124   ENSP00000378126   ENSP00000200307  
    Reactome Protein details: P80098
    Human Recombinant Protein Products for CCL7: 
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for CCL7
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    Novus Biologicals CCL7 Proteins
    Sino Biological Recombinant Protein for CCL7
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL7
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL7 for ontologies           About GeneDecksing



    CCL7 Antibody Products: 
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    Abcam antibodies for CCL7
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    Assay Products for CCL7: 
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    GenScript Custom Assay Services for CCL7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P80098

    ProtoNet protein and cluster: P80098

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL7_HUMAN, P80098
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL7_HUMAN, P80098
    Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte
    anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2
    and CCR3

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA10072545
    GO:0008201heparin binding IEA--
    GO:0031726CCR1 chemokine receptor binding IPI10660125
    GO:0031727CCR2 chemokine receptor binding IEA--
         
    CCL7 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl7):
     hematopoietic system  immune system 

    CCL7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl7tm1Ifc for CCL7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL7 

    miRNA
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    hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCCL7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCL7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL7

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCL7

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL7
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                         Customized lentivirus expression plasmids for stable overexpression of CCL7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL7 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL7
        Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL7 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL7
        Immune response CCR3 signaling in eosinophils


    5/6        Reactome Pathways for CCL7 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for CCL7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for CCL7 (P800982, 3 ENSP000002003074) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AESQ081172, 3, ENSP000002215614MINT-64064 I2D: score=3 STRING: ENSP00000221561
    FEZ1Q996892, 3, ENSP000002789194MINT-64011 I2D: score=5 STRING: ENSP00000278919
    ACKR2O005903, ENSP000002731454I2D: score=4 STRING: ENSP00000273145
    CCR3P516773, ENSP000003500034I2D: score=3 STRING: ENSP00000350003
    MMP2P082533, ENSP000002190704I2D: score=3 STRING: ENSP00000219070
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002548monocyte chemotaxis IC10660125
    GO:0006874cellular calcium ion homeostasis TAS10770925
    GO:0006935chemotaxis TAS9780207
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--

    CCL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL7

    10/29 Novoseek inferred chemical compound relationships for CCL7 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 94.4 309 7507512 (10), 9311806 (8), 9394815 (7), 11090473 (5) (see all 99)
    mcp 3 79.2 41 7589134 (10), 7545673 (9)
    ccl3 69 8 12851650 (1), 15818740 (1), 17178797 (1), 16197470 (1) (see all 5)
    tarc 68.7 7 9153236 (1), 9430724 (1), 10372118 (1), 11964742 (1) (see all 5)
    groalpha 65.3 1 10737895 (1)
    larc 63 4 9153236 (1), 10449163 (1), 11792124 (1)
    teck 59.3 1 10449163 (1)
    mcp 1 56.9 6 7589134 (3), 7545673 (2)
    anaphylatoxin 43.6 2 8855287 (1)
    calcium 36.7 24 8144937 (3), 7759884 (2), 10733106 (1), 9060459 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CCL7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL7 gene: 
    NM_006273.3  

    Unigene Cluster for CCL7:

    Chemokine (C-C motif) ligand 7
    Hs.251526  [show with all ESTs]
    Unigene Representative Sequence: CD521885
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378569(uc002hhz.3 uc010ctf.3) ENST00000394627 ENST00000394630
    ENST00000200307
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL7 (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-130a* hsa-miR-202 hsa-let-7c hsa-miR-23c hsa-let-7i hsa-let-7g
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    Additional mRNA sequence: 

    AF043338.1 BC070240.1 BC092436.1 BC112258.1 BC112260.1 X71087.1 

    1 DOTS entry:

    DT.65286829 

    24/70 AceView cDNA sequences (see all 70):

    NM_002986 AA127067 CA306760 AW294260 BF197516 X72308 BC017850 AW197514 
    AI913629 CD641807 CD520379 CA843078 CD641158 CD520085 U46573 CD642089 
    CR457421 CD521785 W69211 BV203341 CD523198 CD520542 CA843831 NM_006273 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for CCL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL7 expression in normal human tissues (normalized intensities)      CCL7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTATTGT
    CCL7 Expression
    About this image


    CCL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             umbilical cord reticulocytes   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Fibroblast
             Human Dermal Fibroblasts-fetal (HDF-f)   
     
     Lung (Respiratory System)
             alveolar macrophages   

    See CCL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL7

    SOURCE GeneReport for Unigene cluster: Hs.251526
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL7 (see all 15): 
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL7 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl71 , 5 chemokine (C-C motif) ligand 71, 5 73.61(n)1
    63.54(a)1
      11 (49.83 cM)5
    203061  NM_013654.31  NP_038682.11 
     820457125 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.26
    si:dkeyp-59a8.36
    (see all 5)
    si:dkeyp-59a8.3
    (see all 5)
    34(a)
    32(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38304232-38305101)
    20(38310380-38311158)


    ENSEMBL Gene Tree for CCL7 (if available)
    TreeFam Gene Tree for CCL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL7 gene
    CCL112  CCL132  CCL22  CCL82  CCL242  
    18/28 SIMAP similar genes for CCL7 using alignment to 3 protein entries:     CCL7_HUMAN (see all proteins) (see all similar genes):
    MCP-3    CCL11    CCL2    CCL8    CCL13    CCL3
    CCL3L1    CCL3L3    CCL4    CCL4L2    LOC728835    CCL14
    CCL4L1    CCL16    CX3CL1    CCL5    CCL18    CCL22

    CCL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 SNPs in CCL7 are shown (see all 151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819878851,2
    --32595520(+) CCCCCA/GTGTTC 1 -- us2k10--------
    rs177357051,2
    C,F--32595535(+) CCAACT/GTCATC 1 -- us2k14Minor allele frequency- G:0.01NA 262
    rs1142773501,2
    C,F--32595545(+) CGATCA/CTTCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1857501271,2
    --32595603(+) AGAAAG/TAAAAG 1 -- us2k10--------
    rs362318381,2
    C--32595689(-) TAACAC/TATTAG 1 -- us2k10--------
    rs362318371,2
    C,F--32595800(-) TCTCGA/TTTATC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1511728071,2
    --32595801(+) ATAATA/CGAGAG 1 -- us2k10--------
    rs362318361,2
    C,F--32595830(-) CCCCTA/GTGACT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1402724071,2
    --32595850(+) ACGACA/TTAAAG 1 -- us2k10--------
    rs1440980981,2
    --32595856(+) TAAAGC/GTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL7 (32597240 - 32599261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CCL7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 158106    OMIM disorders: --

    20/60 diseases for CCL7 (see all 60):    About MalaCards
    usual interstitial pneumonia    stachybotrys chartarum    b cell deficiency    intrinsic asthma
    t cell deficiency    vernal keratoconjunctivitis    cholera    pulmonary eosinophilia
    eosinophilia    chorioamnionitis    allergic rhinitis    cerebral palsy
    rhinitis    neurofibromatosis    cytomegalovirus infection    bronchopulmonary dysplasia
    keratoconjunctivitis    pneumonia    laryngeal carcinoma    cutaneous t cell lymphoma

    2 diseases from the University of Copenhagen DISEASES database for CCL7:
    Asthma     Eosinophilia

    CCL7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/34 Novoseek inferred disease relationships for CCL7 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 59.4 18 10205198 (2), 15901268 (2), 15715950 (1), 15103673 (1) (see all 9)
    asthma allergic 43 1 8980953 (1)
    nasal polyps 37.2 1 9532637 (1)
    asthma 35.7 10 15715950 (3), 18579545 (1), 8998072 (1), 10902138 (1) (see all 6)
    eosinophilia 29.3 1 10491000 (1)
    allergic rhinitis 27.6 4 10359883 (1), 11150001 (1), 17982926 (1), 12028117 (1)
    necrosis 27.4 6 8833040 (1), 10205198 (1), 14755722 (1), 19131226 (1) (see all 6)
    sclerosis systemic 23.2 6 12847692 (2), 16344498 (1), 16641048 (1)
    tumors 22.9 23 18533557 (5), 11529662 (2), 19424580 (2), 12393570 (1) (see all 13)
    allergy 19.2 2 9800627 (1), 10640766 (1)

    Genetic Association Database (GAD): CCL7
    Human Genome Epidemiology (HuGE) Navigator: CCL7 (19 documents)

    Export disorders for CCL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL7 gene, integrated from 9 sources (see all 350):
    (articles sorted by number of sources associating them with CCL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PubMed id 8461011)1, 2, 3, 9 Opdenakker G.... van Damme J. (1993)
    2. Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. (PubMed id 8318676)1, 2, 9 Minty A.... Caput D. (1993)
    3. Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PubMed id 15715950)1, 4, 9 Park B.L....Shin H.D. (2005)
    4. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2- q12. (PubMed id 7916328)1, 2, 9 Opdenakker G.... van Damme J. (1994)
    5. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PubMed id 8898111)1, 2, 9 Kim K.-S.... Sykes B.D. (1996)
    6. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (PubMed id 1613466)1, 2, 9 van Damme J.... Opdenakker G. (1992)
    7. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PubMed id 9109648)1, 2, 9 Meunier S.... Darbon H. (1997)
    8. MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. (PubMed id 14571188)1, 4, 9 Modi W.S....Winkler C. (2003)
    9. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6354 HGNC: 10634 AceView: CCL11andCCL7 Ensembl:ENSG00000108688 euGenes: HUgn6354
    ECgene: CCL7 Kegg: 6354 H-InvDB: CCL7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL7 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL7 gene:
    Search GeneIP for patents involving CCL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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