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Aliases for CCL5 Gene

Aliases for CCL5 Gene

  • Chemokine (C-C Motif) Ligand 5 2 3
  • SIS-Delta 2 3 4
  • D17S136E 3 4 6
  • TCP228 3 4 6
  • SCYA5 3 4 6
  • Eosinophil Chemotactic Cytokine 3 4
  • T-Cell Specific Protein P288 2 3
  • Beta-Chemokine RANTES 2 3
  • EoCP 3 4
  • Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys) 2
  • Small Inducible Cytokine A5 (RANTES) 2
  • T-Cell Specific RANTES Protein 2
  • T-Cell-Specific Protein RANTES 4
  • T Cell-Specific Protein P228 4
  • Small-Inducible Cytokine A5 4
  • Regulated Upon Activation 2
  • And Presumably Secreted 2
  • C-C Motif Chemokine 5 3
  • Normally T-Expressed 2
  • Member 5 2
  • RANTES 3
  • SISd 3

External Ids for CCL5 Gene

Previous HGNC Symbols for CCL5 Gene

  • D17S136E
  • SCYA5

Previous GeneCards Identifiers for CCL5 Gene

  • GC17M033968
  • GC17M036234
  • GC17M034344
  • GC17M031222
  • GC17M034198
  • GC17M030383

Summaries for CCL5 Gene

Entrez Gene Summary for CCL5 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL5 Gene

CCL5 (Chemokine (C-C Motif) Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include ulcer of lower limbs and african tick-bite fever. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot for CCL5 Gene

  • Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gene Wiki entry for CCL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL5 Gene

Genomics for CCL5 Gene

Regulatory Elements for CCL5 Gene

Genomic Location for CCL5 Gene

Start:
35,871,491 bp from pter
End:
35,880,793 bp from pter
Size:
9,303 bases
Orientation:
Minus strand

Genomic View for CCL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL5 Gene

Proteins for CCL5 Gene

  • Protein details for CCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13501-CCL5_HUMAN
    Recommended name:
    C-C motif chemokine 5
    Protein Accession:
    P13501
    Secondary Accessions:
    • O43646
    • Q0QVW8
    • Q4ZGJ1
    • Q9NYA2
    • Q9UBG2
    • Q9UC99

    Protein attributes for CCL5 Gene

    Size:
    91 amino acids
    Molecular mass:
    9990 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL5 Gene

neXtProt entry for CCL5 Gene

Proteomics data for CCL5 Gene at MOPED

Post-translational modifications for CCL5 Gene

  • N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
  • The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
  • Glycosylation at Ser27 and Ser28
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCL5 (CCL5)

Protein Products

No data available for DME Specific Peptides for CCL5 Gene

Domains for CCL5 Gene

Gene Families for CCL5 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL5 Gene

Suggested Antigen Peptide Sequences for CCL5 Gene

Graphical View of Domain Structure for InterPro Entry

P13501

UniProtKB/Swiss-Prot:

CCL5_HUMAN :
  • P13501
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL5: view

Function for CCL5 Gene

Molecular function for CCL5 Gene

UniProtKB/Swiss-Prot Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
UniProtKB/Swiss-Prot Induction: By mitogens

Gene Ontology (GO) - Molecular Function for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IDA 10734056
GO:0004672 protein kinase activity IDA 10734056
GO:0005515 protein binding IPI 23480650
GO:0008009 chemokine activity NAS 7524281
GO:0016004 phospholipase activator activity IDA 10734056
genes like me logo Genes that share ontologies with CCL5: view

Phenotypes for CCL5 Gene

genes like me logo Genes that share phenotypes with CCL5: view

Animal Models for CCL5 Gene

MGI Knock Outs for CCL5:

Animal Model Products

CRISPR Products

miRNA for CCL5 Gene

miRTarBase miRNAs that target CCL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCL5 Gene

Localization for CCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL5 Gene COMPARTMENTS Subcellular localization image for CCL5 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCL5: view

Pathways for CCL5 Gene

genes like me logo Genes that share pathways with CCL5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0002407 dendritic cell chemotaxis TAS 18337562
GO:0002548 monocyte chemotaxis IC 10660125
GO:0002676 regulation of chronic inflammatory response TAS 10488085
GO:0006468 protein phosphorylation IDA 10734056
genes like me logo Genes that share ontologies with CCL5: view

Compounds for CCL5 Gene

(2) Drugbank Compounds for CCL5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Heparin Disaccharide Iii-S
target
Heparin Disaccharide I-S
target

(117) Novoseek inferred chemical compound relationships for CCL5 Gene

Compound -log(P) Hits PubMed IDs
rantes 99.4 844
ccl3 87.5 88
tarc 80.3 26
groalpha 79.7 24
mip 1alpha 77.9 14
genes like me logo Genes that share compounds with CCL5: view

Transcripts for CCL5 Gene

mRNA/cDNA for CCL5 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL5 Gene

Chemokine (C-C motif) ligand 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL5 Gene

No ASD Table

Relevant External Links for CCL5 Gene

GeneLoc Exon Structure for
CCL5
ECgene alternative splicing isoforms for
CCL5

Expression for CCL5 Gene

mRNA expression in normal human tissues for CCL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL5 Gene

This gene is overexpressed in Whole Blood (33.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCL5 Gene

SOURCE GeneReport for Unigene cluster for CCL5 Gene Hs.514821

mRNA Expression by UniProt/SwissProt for CCL5 Gene

P13501-CCL5_HUMAN
Tissue specificity: T-cell and macrophage specific
genes like me logo Genes that share expressions with CCL5: view

In Situ Assay Products

Orthologs for CCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL5 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CCL5 35
  • 85.71 (n)
  • 81.32 (a)
dog
(Canis familiaris)
Mammalia CCL5 35
  • 85.71 (n)
  • 75.82 (a)
mouse
(Mus musculus)
Mammalia Ccl5 35
  • 85.35 (n)
  • 80.22 (a)
Ccl5 16
rat
(Rattus norvegicus)
Mammalia Ccl5 35
  • 88.6 (n)
  • 82.89 (a)
chicken
(Gallus gallus)
Aves CCL5 35
  • 64.89 (n)
  • 62.67 (a)
Species with no ortholog for CCL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL5 Gene

ENSEMBL:
Gene Tree for CCL5 (if available)
TreeFam:
Gene Tree for CCL5 (if available)

Paralogs for CCL5 Gene

genes like me logo Genes that share paralogs with CCL5: view

No data available for Paralogs for CCL5 Gene

Variants for CCL5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL5 Gene

P13501-CCL5_HUMAN
The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3

Sequence variations from dbSNP and Humsavar for CCL5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1065341 -- 35,871,589(-) GGAAC(A/G)CTGCA utr-variant-3-prime
rs1142895 -- 35,872,109(-) cccat(C/G)tctac utr-variant-3-prime
rs1142896 -- 35,872,107(-) catct(C/G)tacta utr-variant-3-prime
rs1800825 -- 35,880,482(-) TTTCT(C/T)TTCCG upstream-variant-2KB
rs2107538 -- 35,880,776(+) TCTTA(C/T)CTCCT upstream-variant-2KB

Relevant External Links for CCL5 Gene

HapMap Linkage Disequilibrium report
CCL5
Human Gene Mutation Database (HGMD)
CCL5

No data available for Structural Variations from Database of Genomic Variants (DGV) for CCL5 Gene

Disorders for CCL5 Gene

(2) University of Copenhagen DISEASES for CCL5 Gene

(97) Novoseek inferred disease relationships for CCL5 Gene

Disease -log(P) Hits PubMed IDs
inflammation 76.3 83
necrosis 66.6 108
asthma 59.3 62
nasal polyps 58.7 35
immunodeficiency 58.4 37

Relevant External Links for CCL5

Genetic Association Database (GAD)
CCL5
Human Genome Epidemiology (HuGE) Navigator
CCL5
genes like me logo Genes that share disorders with CCL5: view

No data available for UniProtKB/Swiss-Prot for CCL5 Gene

Publications for CCL5 Gene

  1. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. (PMID: 1380064) Kameyoshi Y. … Schroeder J.-M. (J. Exp. Med. 1992) 3 4 23
  2. Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type. (PMID: 7537088) Skelton N.J. … Schall T.J. (Biochemistry 1995) 3 4 23
  3. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. (PMID: 8525373) Cocchi F. … Lusso P. (Science 1995) 3 4 23
  4. Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. (PMID: 11125885) McDermott D.H. … Murphy P.M. (AIDS 2000) 3 23 48
  5. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. (PMID: 11197694) Fryer A.A. … Hajeer A.H. (Genes Immun. 2000) 3 23 48

Products for CCL5 Gene

Sources for CCL5 Gene

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