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CCL5 Gene

protein-coding   GIFtS: 66
GCID: GC17M034198

Chemokine (C-C Motif) Ligand 5

(Previous name: small inducible cytokine A5 (RANTES))
(Previous symbols: D17S136E, SCYA5)
  See CCL5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 51 2     Small Inducible Cytokine Subfamily A (Cys-Cys)1
D17S136E1 2 3 5     T-Cell Specific RANTES Protein1
SCYA51 2 3 5     RANTES2
SIS-delta1 2 3     SISd2
TCP2282 3 5     C-C Motif Chemokine 52
Beta-Chemokine RANTES1 2     eoCP2
T-Cell Specific Protein P2881 2     Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted2
Eosinophil Chemotactic Cytokine2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 52
And Presumably Secreted1     EoCP3
Member 51     Small-Inducible Cytokine A53
Normally T-Expressed1     T Cell-Specific Protein P2283
Regulated Upon Activation1     T-Cell-Specific Protein RANTES3
Small Inducible Cytokine A5 (RANTES)1     

External Ids:    HGNC: 106321   Entrez Gene: 63522   Ensembl: ENSG000001615707   OMIM: 1870115   UniProtKB: P135013   

Export aliases for CCL5 gene to outside databases

Previous GC identifers: GC17M033968 GC17M036234 GC17M034344 GC17M031222 GC17M030383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL5 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This
chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper
cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine
is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands
for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the
R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants
that encode different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL5 Gene:
CCL5 (chemokine (C-C motif) ligand 5) is a protein-coding gene. Diseases associated with CCL5 include hiv-1 disease, rapid progression of, and hiv-1 disease, delayed progression of. GO annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of
histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major
HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition
of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68)
acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed
form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and
RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils

Gene Wiki entry for CCL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL5 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL5 promoter sequence
   Search Chromatin IP Primers for CCL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

CCL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034198:  view genomic region     (about GC identifiers)

Start:
34,198,495 bp from pter      End:
34,207,797 bp from pter
Size:
9,303 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501 (See protein sequence)
Recommended Name: C-C motif chemokine 5 precursor  
Size: 91 amino acids; 9990 Da
Mass spectrometry: Mass=7515; Mass_error=1; Method=SELDI; Range=27-91; Source=PubMed:15923218;
Mass spectrometry: Mass=7862.8; Mass_error=1.1; Method=Electrospray; Range=24-91; Source=PubMed:1380064;
Mass spectrometry: Mass=8355; Mass_error=10; Method=Electrospray; Range=24-91; Note=O-glycosylated;
Source=PubMed:1380064;
Selected PDB 3D structures from and Proteopedia for CCL5 (see all 11):
1B3A (3D)        1EQT (3D)        1HRJ (3D)        1RTN (3D)        1RTO (3D)        1U4L (3D)    
Secondary accessions: O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99

Explore the universe of human proteins at neXtProt for CCL5: NX_P13501

Explore proteomics data for CCL5 at MOPED

Post-translational modifications: 

  • N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from
    peripheral blood leukocytes and cultured sarcoma cells1
  • The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are
    assigned by similarity1
  • Glycosylation2 at Ser27, Ser28

  • See CCL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265665.1  NP_002976.2  

    ENSEMBL proteins: 
     ENSP00000293272   ENSP00000375216   ENSP00000465234  
    Reactome Protein details: P13501

    CCL5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCL5 Protein
    R&D Systems Recombinant & Natural Proteins for CCL5 (CCL5/RANTES)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CCL5
    OriGene Protein Over-expression Lysate for CCL5
    OriGene MassSpec for CCL5
    OriGene Custom Protein Services for CCL5
    GenScript Purified and Recombinant Proteins for CCL5
    Novus Biologicals CCL5 Proteins
    Novus Biologicals CCL5 Lysate
    Sino Biological Recombinant Protein for CCL5
    Sino Biological Cell Lysate for CCL5
    ProSpec Recombinant Protein for CCL5
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL5 

    CCL5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL5 (CCL5/RANTES)
    Cell Signaling Technology (CST) Antibodies for CCL5 
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    OriGene Custom Antibody Services for CCL5
    Novus Biologicals CCL5 Antibodies
    Abcam antibodies for CCL5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CCL5
    LSBio Antibodies in human, mouse, rat for CCL5

    CCL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL5
    R&D Systems Flow Cytometry Kits for CCL5 (CCL5/RANTES)         (see all)
    GenScript Custom Assay Services for CCL5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CCL5:  
                        Human RANTES Instant ELISA 128 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P13501

    ProtoNet protein and cluster: P13501

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL5_HUMAN, P13501
    Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of
    histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major
    HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition
    of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68)
    acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed
    form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and
    RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils
    Induction: By mitogens

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IDA10734056
    GO:0004672protein kinase activity IDA10734056
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity NAS7524281
    GO:0016004phospholipase activator activity IDA10734056
         
    Find genes that share ontologies with CCL5           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl5):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CCL5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccl5tm1Hso for CCL5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL5:
    hsa-mir-98-5p (MIRT005677), hsa-mir-125a-5p (MIRT005678)

    Block miRNA regulation of human, mouse, rat CCL5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCCL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL5
    Predesigned siRNA for gene silencing in human, mouse, rat CCL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL5

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL5 (see all 6)
    OriGene ORF clones in mouse, rat for CCL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    Sino Biological Human cDNA Clone for CCL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5
    Addgene plasmids for CCL5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL5
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14154) for CCL5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL5_HUMAN, P13501: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CCL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL5 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with CCL5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL5
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL5 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for CCL5
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for CCL5
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    Selected BioSystems Pathways for CCL5 (see all 8)
        EBV LMP1 signaling
    Toll-like receptor signaling pathway
    Vitamin B12 Metabolism
    TWEAK Signaling Pathway
    Syndecan-1-mediated signaling events


    2 Reactome Pathways for CCL5
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    Selected Kegg Pathways  (Kegg details for CCL5) (see all 12):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL5 (see all 25): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              Endothelial Cell Biology in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL5 (P135011, 2, 3 ENSP000002932724) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR5P516811, 2, 3, ENSP000002923034EBI-2848366,EBI-489374 MINT-8416147 MINT-8416085 MINT-8416125 MINT-8416173 I2D: score=3 STRING: ENSP00000292303
    DPP4P274872, 3, ENSP000003537314MINT-8090927 I2D: score=2 STRING: ENSP00000353731
    ACKR2O005903, ENSP000002731454I2D: score=4 STRING: ENSP00000273145
    CCR1P322463, ENSP000002961404I2D: score=4 STRING: ENSP00000296140
    VCANP136113, ENSP000002650774I2D: score=4 STRING: ENSP00000265077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 63):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0002407dendritic cell chemotaxis TAS18337562
    GO:0002548monocyte chemotaxis IC10660125
    GO:0002676regulation of chronic inflammatory response TAS10488085
    GO:0006468protein phosphorylation IDA10734056

    Find genes that share ontologies with CCL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL5

    2 DrugBank Compounds for CCL5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heparin Disaccharide I-S-- --target--17139284 17016423
    Heparin Disaccharide Iii-S-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for CCL5 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 99.4 5828 11435978 (13), 9192918 (13), 10336000 (12), 15794069 (12) (see all 99)
    ccl3 87.5 120 16197470 (5), 14761932 (3), 19906920 (2), 20205697 (2) (see all 72)
    tarc 80.3 27 17460400 (2), 9169480 (2), 18691293 (2), 15941911 (1) (see all 23)
    groalpha 79.7 24 16869002 (4), 10337033 (2), 16047084 (2), 19497617 (2) (see all 17)
    mip 1alpha 77.9 16 18403790 (3), 20205697 (2), 10820198 (1), 16211583 (1) (see all 11)
    mcp 4 70.8 1 10640766 (1)
    ccl4 67.2 83 14761932 (2), 12960247 (2), 20046229 (2), 18223665 (2) (see all 52)
    mcp 2 67.1 2 16323127 (1), 10364178 (1)
    ena 78 65.1 1 11503269 (1)
    mcp 1 64.3 9 20205697 (2), 10559777 (2), 16918500 (1), 20332253 (1) (see all 5)



    Find genes that share compounds with CCL5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL5 gene (2 alternative transcripts): 
    NM_001278736.1  NM_002985.2  

    Unigene Cluster for CCL5:

    Chemokine (C-C motif) ligand 5
    Hs.514821  [show with all ESTs]
    Unigene Representative Sequence: BM917378
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293272(uc002hkf.3) ENST00000366113 ENST00000463941
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCCL5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5
    Addgene plasmids for CCL5 
    Primer
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    OriGene qPCR primer pairs and template standards for CCL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL5
      QuantiTect SYBR Green Assays in human, mouse, rat CCL5
      QuantiFast Probe-based Assays in human, mouse, rat CCL5
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-14154) for CCL5 

    Additional mRNA sequence: 

    AF043341.1 AF266753.1 AK312212.1 BC008600.1 DQ230537.1 M21121.1 

    4 DOTS entries:

    DT.412343  DT.97862489  DT.87014719  DT.120906134 

    1 AceView cDNA sequence:

    BF996938 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CCL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAATCGGC
    CCL5 Expression
    About this image


    CCL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    CCL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514821

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Tissue specificity: T-cell and macrophage specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL5 (see all 25): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              Endothelial Cell Biology in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat CCL5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl51 , 5 chemokine (C-C motif) ligand 51, 5 85.35(n)1
    80.22(a)1
      11 (50.66 cM)5
    203041  NM_013653.31  NP_038681.21 
     835257785 
    chicken
    (Gallus gallus)
    Aves CCL51 chemokine (C-C motif) ligand 5 64.89(n)
    62.67(a)
      417465  NM_001045832.1  NP_001039297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    31(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378


    ENSEMBL Gene Tree for CCL5 (if available)
    TreeFam Gene Tree for CCL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL5 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
    CCL232  CCL3L32  CCL15-CCL142  CCL42  CCL182  
    Selected SIMAP similar genes for CCL5 using alignment to 3 protein entries:     CCL5_HUMAN (see all proteins) (see all similar genes):
    CCL4    CCL15    CCL24    CCL4L2    LOC728835    CCL3L1
    CCL3L3    CCL4L1    CCL3    CCL26    CCL14    MCP-3
    CCL18    CCL13    CCL8    CCL7    CCL22    CCL16

    Find genes that share paralogs with CCL5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CCL5_HUMAN, P13501: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3


    Selected SNPs for CCL5 (see all 248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339216451,2
    C--30393697(+) AATAA-/T/T   
       AT
    /TT
    TATTA
    2 -- us2k1 cds10--------
    rs113883791,2
    C--30393698(+) TTATT-/ATT   
      
    /T/TAT
    GAGAC
    3 -- us2k1 cds10--------
    rs289147951,2
    F--30393721(-) TCTCA-/ATAATAAT 1 -- cds15Minor allele frequency- ATA:0.17NS 164
    rs289120691,2
    C,F--30393980(-) ACGGCC/ATGTAA 1 -- us2k18Minor allele frequency- A:0.12NS CSA WA NA 419
    rs2016847661,2
    C--34202042(+) AAAAA-/AGAAAT 1 -- int10--------
    rs3717528481,2
    C--34209310(+) CGTCT-/AAAAAA 1 -- us2k10--------
    rs289148161,2
    C,F--34261437(-) CTTTAA/CGGTGG 1 -- ds50017Minor allele frequency- C:0.05NS NA EA 416
    rs1927608921,2
    --34261539(+) AGGGGC/TAAGAG 1 -- ds50010--------
    rs289148151,2
    C--34261891(-) ACCATA/GAAGCT 1 -- ut317Minor allele frequency- G:0.00NS NA 194
    rs1848739051,2
    C--34261901(+) TTGCAC/TTGAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCL5 (34198495 - 34207797 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCL5: --
    Human Gene Mutation Database (HGMD): CCL5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187011    OMIM disorders: --

    Selected diseases for CCL5 (see all 23):    
    About MalaCards
    hiv-1 disease, rapid progression of    hiv-1 disease, delayed progression of    ulcer of lower limbs    african tick-bite fever
    meningoencephalitis    griscelli syndrome type 2    periapical granuloma    mediterranean spotted fever
    folliculitis    bullous skin disease    meningococcemia    viral encephalitis
    griscelli syndrome    polymyalgia rheumatica    skin disease    cryptosporidiosis
    viral meningitis    genital herpes    lichen planus    mycetoma

    2 diseases from the University of Copenhagen DISEASES database for CCL5:
    Asthma     Encephalitis

    Find genes that share disorders with CCL5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL5 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 76.3 84 15740484 (2), 20459697 (2), 10606930 (2), 16449815 (2) (see all 74)
    necrosis 66.6 180 9003213 (2), 16413378 (2), 11330934 (2), 19291322 (2) (see all 99)
    asthma 59.3 83 17678722 (4), 8970374 (3), 20430255 (3), 11197694 (3) (see all 44)
    nasal polyps 58.7 39 14687706 (4), 16903328 (4), 19522185 (4), 16456693 (3) (see all 18)
    immunodeficiency 58.4 41 10979927 (2), 10364494 (2), 10196243 (2), 9359702 (1) (see all 34)
    hiv infections 55.3 32 10917892 (2), 17671228 (2), 12634395 (2), 16437690 (2) (see all 25)
    eosinophilia 55.2 19 12853519 (2), 15794069 (2), 12388374 (1), 11398366 (1) (see all 15)
    asthma allergic 49.2 7 8626989 (2), 15592421 (1), 20430255 (1), 18716401 (1) (see all 6)
    virus infection 47 39 8977509 (3), 10364494 (3), 12388374 (2), 10799898 (2) (see all 27)
    dermatitis atopic 45.6 22 17117952 (6), 8906106 (3), 15948978 (2), 10444253 (1) (see all 13)

    Genetic Association Database (GAD): CCL5
    Human Genome Epidemiology (HuGE) Navigator: CCL5 (177 documents)

    Export disorders for CCL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL5 gene, integrated from 10 sources (see all 1945):
    (articles sorted by number of sources associating them with CCL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection. (PubMed id 15978191)1, 4, 9 Duan Z.P....Zheng B.J. (Chin. Med. J. 2005)
    2. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. (PubMed id 15368437)1, 4, 9 Wasmuth H.E....Lammert F. (Hepatology 2004)
    3. RANTES promoter genotype and gastric cancer risk in a Japanese population. (PubMed id 19846984)1, 4, 9 Tahara T....Arisawa T. (Anticancer Res. 2009)
    4. Association between RANTES polymorphisms and asthma severity among Tunisian children. (PubMed id 17678722)1, 4, 9 Lachheb J....Hamzaoui A. (Hum. Immunol. 2007)
    5. CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis. (PubMed id 17884183)1, 4, 9 van Veen T....Uitdehaag B.M. (J. Neuroimmunol. 2007)
    6. MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease. (PubMed id 17728497)1, 4, 9 Joo K.W....Ahn C. (J. Korean Med. Sci. 2007)
    7. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)
    8. Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy. (PubMed id 20203694)1, 4, 9 Pettigrew K.A....Maxwell A.P. (J. Hum. Genet. 2010)
    9. RANTES gene polymorphisms and asthma risk: A meta-analysis. (PubMed id 20430255)1, 4, 9 Zhang Y.G....Fan H. (Arch. Med. Res. 2010)
    10. RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma. (PubMed id 17990036)1, 4, 9 Sohn M.H....Kim K.E. (Lung 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6352 HGNC: 10632 AceView: CCL5.1 Ensembl:ENSG00000161570 euGenes: HUgn6352
    ECgene: CCL5 Kegg: 6352 H-InvDB: CCL5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccl5/
    Wikipedia http://en.wikipedia.org/wiki/RANTES

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL5 gene:
    Search GeneIP for patents involving CCL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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