Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL5 Gene

protein-coding   GIFtS: 66
GCID: GC17M034198

Chemokine (C-C Motif) Ligand 5

(Previous name: small inducible cytokine A5 (RANTES))
(Previous symbols: D17S136E, SCYA5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 51 2     Small Inducible Cytokine Subfamily A (Cys-Cys)1
D17S136E1 2 3 5     T-Cell Specific RANTES Protein1
SCYA51 2 3 5     RANTES2
SIS-delta1 2 3     SISd2
TCP2282 3 5     C-C Motif Chemokine 52
Beta-Chemokine RANTES1 2     eoCP2
T-Cell Specific Protein P2881 2     Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted2
Eosinophil Chemotactic Cytokine2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 52
And Presumably Secreted1     EoCP3
Member 51     Small-Inducible Cytokine A53
Normally T-Expressed1     T Cell-Specific Protein P2283
Regulated Upon Activation1     T-Cell-Specific Protein RANTES3
Small Inducible Cytokine A5 (RANTES)1     

External Ids:    HGNC: 106321   Entrez Gene: 63522   Ensembl: ENSG000001615707   OMIM: 1870115   UniProtKB: P135013   

Export aliases for CCL5 gene to outside databases

Previous GC identifers: GC17M033968 GC17M036234 GC17M034344 GC17M031222 GC17M030383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL5 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This
chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper
cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine
is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands
for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the
R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants
that encode different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL5 Gene: 
CCL5 (chemokine (C-C motif) ligand 5) is a protein-coding gene. Diseases associated with CCL5 include ulcer of lower limbs, and meningoencephalitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Toll-like receptor signaling pathway. GO annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of
histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major
HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition
of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68)
acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed
form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and
RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils

Gene Wiki entry for CCL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL5 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

CCL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034198:  view genomic region     (about GC identifiers)

Start:
34,198,495 bp from pter      End:
34,207,797 bp from pter
Size:
9,303 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501 (See protein sequence)
Recommended Name: C-C motif chemokine 5 precursor  
Size: 91 amino acids; 9990 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7515; Mass_error=1; Method=SELDI; Range=27-91; Source=PubMed:15923218;
Mass spectrometry: Mass=7862.8; Mass_error=1.1; Method=Electrospray; Range=24-91; Source=PubMed:1380064;
Mass spectrometry: Mass=8355; Mass_error=10; Method=Electrospray; Range=24-91; Note=O-glycosylated;
Source=PubMed:1380064;
6/11 PDB 3D structures from and Proteopedia for CCL5 (see all 11):
1B3A (3D)        1EQT (3D)        1HRJ (3D)        1RTN (3D)        1RTO (3D)        1U4L (3D)    
Secondary accessions: O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99

Explore the universe of human proteins at neXtProt for CCL5: NX_P13501

Explore proteomics data for CCL5 at MOPED 

Post-translational modifications:

  • UniProtKB: N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from
    peripheral blood leukocytes and cultured sarcoma cells
  • UniProtKB: The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are
    assigned by similarity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13501

  • CCL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265665.1  NP_002976.2  

    ENSEMBL proteins: 
     ENSP00000293272   ENSP00000375216   ENSP00000465234  
    Reactome Protein details: P13501
    Human Recombinant Protein Products for CCL5: 
    EMD Millipore Purified and/or Recombinant CCL5 Protein
    R&D Systems Recombinant & Natural Proteins for CCL5 (CCL5/RANTES)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL5
    OriGene Protein Over-expression Lysate for CCL5
    OriGene MassSpec for CCL5 
    OriGene Custom Protein Services for CCL5
    GenScript Purified and Recombinant Proteins for CCL5
    Novus Biologicals CCL5 Proteins
    Novus Biologicals CCL5 Lysates
    Sino Biological Recombinant Protein for CCL5
    Sino Biological Cell Lysate for CCL5 
    ProSpec Recombinant Protein for CCL5
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    CCL5 for ontologies           About GeneDecksing



    CCL5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL5
    R&D Systems Antibodies for CCL5 (CCL5/RANTES)
    Cell Signaling Technology (CST) Antibodies for CCL5 
    OriGene Antibodies for CCL5
    OriGene Custom Antibody Services for CCL5
    GenScript Superior Antibodies for CCL5
    Novus Biologicals CCL5 Antibodies
    Abcam antibodies for CCL5
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CCL5
    LSBio Antibodies in human, mouse, rat for CCL5 

    Assay Products for CCL5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL5
    R&D Systems Flow Cytometry Kits for CCL5 (CCL5/RANTES)         (see all)
    GenScript Custom Assay Services for CCL5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P13501

    ProtoNet protein and cluster: P13501

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL5_HUMAN, P13501
    Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of
    histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major
    HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition
    of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68)
    acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed
    form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and
    RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils
    Induction: By mitogens

         Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IDA10734056
    GO:0004672protein kinase activity IDA10734056
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity NAS7524281
    GO:0016004phospholipase activator activity IDA10734056
         
    CCL5 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl5):
     cellular  hematopoietic system  immune system 

    CCL5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl5tm1Hso for CCL5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL5 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL5:
    hsa-mir-98 (MIRT005677), hsa-mir-125a-5p (MIRT005678)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCCL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL5
    Sirion Biotech Customized adenovirus for overexpression of CCL5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL5 (see all 7)
    OriGene ORF clones in mouse, rat for CCL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    Sino Biological Human cDNA Clone for CCL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5
    Sirion Biotech Customized lentivirus for stable overexpression of CCL5 
                         Customized lentivirus expression plasmids for stable overexpression of CCL5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL5
    Search LifeMap BioReagents cell lines for CCL5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL5 About   (see all 27)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CCL5
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL5 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for CCL5
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for CCL5
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/6 BioSystems Pathways for CCL5 (see all 6)
        EBV LMP1 signaling
    Toll-like receptor signaling pathway
    TWEAK Signaling Pathway
    Syndecan-1-mediated signaling events
    Syndecan-4-mediated signaling events


    5/8        Reactome Pathways for CCL5 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/12         Kegg Pathways  (Kegg details for CCL5) (see all 12):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    CCL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for CCL5 (P135012, 3 ENSP000002932724) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR5P516812, 3, ENSP000002923034MINT-8416147 MINT-8416085 MINT-8416125 MINT-8416173 I2D: score=3 STRING: ENSP00000292303
    DPP4P274872, 3, ENSP000003537314MINT-8090927 I2D: score=2 STRING: ENSP00000353731
    ACKR2O005903, ENSP000002731454I2D: score=4 STRING: ENSP00000273145
    CCR1P322463, ENSP000002961404I2D: score=4 STRING: ENSP00000296140
    VCANP136113, ENSP000002650774I2D: score=4 STRING: ENSP00000265077
    About this table

    Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0002407dendritic cell chemotaxis TAS18337562
    GO:0002548monocyte chemotaxis IC10660125
    GO:0002676regulation of chronic inflammatory response TAS10488085
    GO:0006468protein phosphorylation IDA10734056

    CCL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL5

    2 DrugBank Compounds for CCL5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heparin Disaccharide I-S-- --target--17139284 17016423
    Heparin Disaccharide Iii-S-- --target--17139284 17016423

    10/117 Novoseek inferred chemical compound relationships for CCL5 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 99.4 5828 11435978 (13), 9192918 (13), 10336000 (12), 15794069 (12) (see all 99)
    ccl3 87.5 120 16197470 (5), 14761932 (3), 19906920 (2), 20205697 (2) (see all 72)
    tarc 80.3 27 17460400 (2), 9169480 (2), 18691293 (2), 15941911 (1) (see all 23)
    groalpha 79.7 24 16869002 (4), 10337033 (2), 16047084 (2), 19497617 (2) (see all 17)
    mip 1alpha 77.9 16 18403790 (3), 20205697 (2), 10820198 (1), 16211583 (1) (see all 11)
    mcp 4 70.8 1 10640766 (1)
    ccl4 67.2 83 14761932 (2), 12960247 (2), 20046229 (2), 18223665 (2) (see all 52)
    mcp 2 67.1 2 16323127 (1), 10364178 (1)
    ena 78 65.1 1 11503269 (1)
    mcp 1 64.3 9 20205697 (2), 10559777 (2), 16918500 (1), 20332253 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CCL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL5 gene (2 alternative transcripts): 
    NM_001278736.1  NM_002985.2  

    Unigene Cluster for CCL5:

    Chemokine (C-C motif) ligand 5
    Hs.514821  [show with all ESTs]
    Unigene Representative Sequence: BM917378
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293272(uc002hkf.3) ENST00000366113 ENST00000463941
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCCL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL5
    Clone
    Products:
         
    OriGene clones in human, mouse for CCL5 (see all 7)
    OriGene ORF clones in mouse, rat for CCL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5
    Sirion Biotech Customized lentivirus for stable overexpression of CCL5 
                         Customized lentivirus expression plasmids for stable overexpression of CCL5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL5

    Additional mRNA sequence: 

    AF043341.1 AF266753.1 AK312212.1 BC008600.1 DQ230537.1 M21121.1 

    4 DOTS entries:

    DT.412343  DT.97862489  DT.87014719  DT.120906134 

    1 AceView cDNA sequence:

    BF996938 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CCL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL5 expression in normal human tissues (normalized intensities)      CCL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAATCGGC
    CCL5 Expression
    About this image


    CCL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             T-Cytotoxic Cells Thymus
             Peripheral blood Pan-T Cells   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...

    See CCL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL5

    SOURCE GeneReport for Unigene cluster: Hs.514821

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Tissue specificity: T-cell and macrophage specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL5 (see all 25): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              Endothelial Cell Biology in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl51 , 5 chemokine (C-C motif) ligand 51, 5 85.35(n)1
    80.22(a)1
      11 (50.66 cM)5
    203041  NM_013653.31  NP_038681.21 
     835257785 
    chicken
    (Gallus gallus)
    Aves CCL51 chemokine (C-C motif) ligand 5 64.04(n)
    58.43(a)
      417465  NM_001045832.1  NP_001039297.1 


    ENSEMBL Gene Tree for CCL5 (if available)
    TreeFam Gene Tree for CCL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL5 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
    CCL232  CCL3L32  CCL15-CCL142  CCL42  CCL182  
    18/30 SIMAP similar genes for CCL5 using alignment to 3 protein entries:     CCL5_HUMAN (see all proteins) (see all similar genes):
    CCL4    CCL15    CCL24    CCL4L2    LOC728835    CCL3L1
    CCL3L3    CCL4L1    CCL3    CCL26    CCL14    MCP-3
    CCL18    CCL13    CCL8    CCL7    CCL22    CCL16

    CCL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Polymorphism: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3


    10/248 SNPs in CCL5 are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0430434
    ----see VAR_0430432 S F mis40--------
    rs339216451,2
    C--30393697(+) AATAA-/T/T   
       AT
    /TT
    TATTA
    2 -- us2k1 cds10--------
    rs113883791,2
    C--30393698(+) TTATT-/ATT   
      
    /T/TAT
    GAGAC
    3 -- us2k1 cds10--------
    rs289147951,2
    F--30393721(-) TCTCA-/ATAATAAT 1 -- cds15Minor allele frequency- ATA:0.17NS 164
    rs289120691,2
    C,F--30393980(-) ACGGCC/ATGTAA 1 -- us2k18Minor allele frequency- A:0.12NS CSA WA NA 419
    rs2016847661,2
    C--34202042(+) AAAAA-/AGAAAT 1 -- int10--------
    rs3717528481,2
    C--34209310(+) CGTCT-/AAAAAA 1 -- us2k10--------
    rs289148161,2
    C,F--34261437(-) CTTTAA/CGGTGG 1 -- ds50017Minor allele frequency- C:0.05NS NA EA 416
    rs1927608921,2
    --34261539(+) AGGGGC/TAAGAG 1 -- ds50010--------
    rs289148151,2
    C--34261891(-) ACCATA/GAAGCT 1 -- ut317Minor allele frequency- G:0.00NS NA 194

    HapMap Linkage Disequilibrium report for CCL5 (34198495 - 34207797 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCL5: --

    Human Gene Mutation Database (HGMD): CCL5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 187011    OMIM disorders: --

    20/215 diseases for CCL5 (see all 215):    About MalaCards
    ulcer of lower limbs    meningoencephalitis    african tick-bite fever    bullous skin disease
    coronary arteriosclerosis    mast-cell leukemia    griscelli syndrome type 2    griscelli syndrome
    polymyalgia rheumatica    periapical granuloma    meningococcemia    intrinsic asthma
    viral meningitis    viral encephalitis    cryptosporidiosis    genital herpes
    chikungunya    skin disease    localized scleroderma    erythema multiforme

    2 diseases from the University of Copenhagen DISEASES database for CCL5:
    Asthma     Encephalitis

    CCL5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for CCL5 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 76.3 84 15740484 (2), 20459697 (2), 10606930 (2), 16449815 (2) (see all 74)
    necrosis 66.6 180 9003213 (2), 16413378 (2), 11330934 (2), 19291322 (2) (see all 99)
    asthma 59.3 83 17678722 (4), 8970374 (3), 20430255 (3), 11197694 (3) (see all 44)
    nasal polyps 58.7 39 14687706 (4), 16903328 (4), 19522185 (4), 16456693 (3) (see all 18)
    immunodeficiency 58.4 41 10979927 (2), 10364494 (2), 10196243 (2), 9359702 (1) (see all 34)
    hiv infections 55.3 32 10917892 (2), 17671228 (2), 12634395 (2), 16437690 (2) (see all 25)
    eosinophilia 55.2 19 12853519 (2), 15794069 (2), 12388374 (1), 11398366 (1) (see all 15)
    asthma allergic 49.2 7 8626989 (2), 15592421 (1), 20430255 (1), 18716401 (1) (see all 6)
    virus infection 47 39 8977509 (3), 10364494 (3), 12388374 (2), 10799898 (2) (see all 27)
    dermatitis atopic 45.6 22 17117952 (6), 8906106 (3), 15948978 (2), 10444253 (1) (see all 13)

    Genetic Association Database (GAD): CCL5
    Human Genome Epidemiology (HuGE) Navigator: CCL5 (177 documents)

    Export disorders for CCL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL5 gene, integrated from 9 sources (see all 1923):
    (articles sorted by number of sources associating them with CCL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection. (PubMed id 15978191)1, 4, 9 Duan Z.P....Zheng B.J. (2005)
    2. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. (PubMed id 15368437)1, 4, 9 Wasmuth H.E....Lammert F. (2004)
    3. RANTES promoter genotype and gastric cancer risk in a Japanese population. (PubMed id 19846984)1, 4, 9 Tahara T....Arisawa T. (2009)
    4. Association between RANTES polymorphisms and asthma severity among Tunisian children. (PubMed id 17678722)1, 4, 9 Lachheb J....Hamzaoui A. (2007)
    5. CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis. (PubMed id 17884183)1, 4, 9 van Veen T....Uitdehaag B.M. (2007)
    6. MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease. (PubMed id 17728497)1, 4, 9 Joo K.W....Ahn C. (2007)
    7. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 Sanchez E....Koeleman B.P. (2006)
    8. Resequencing of the CCL5 and CCR5 genes and investiga tion of variants for association with diabetic nephropathy. (PubMed id 20203694)1, 4, 9 Pettigrew K.A....Maxwell A.P. (2010)
    9. RANTES gene polymorphisms and asthma risk: A meta-ana lysis. (PubMed id 20430255)1, 4, 9 Zhang Y.G....Fan H. (2010)
    10. RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma. (PubMed id 17990036)1, 4, 9 Sohn M.H....Kim K.E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6352 HGNC: 10632 AceView: CCL5.1 Ensembl:ENSG00000161570 euGenes: HUgn6352
    ECgene: CCL5 Kegg: 6352 H-InvDB: CCL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccl5/
    Wikipedia http://en.wikipedia.org/wiki/RANTES

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL5 gene:
    Search GeneIP for patents involving CCL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Purified and/or Recombinant CCL5 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL5
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCL5 (CCL5/RANTES)   Browse Cell Culture Products  
     ELISAs for CCL5 (CCL5/RANTES)   Flow Cytometry Kits for CCL5 (CCL5/RANTES)  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules for CCL5 (CCL5/RANTES)   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for CCL5 (CCL5/RANTES)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CCL5 (CCL5/RANTES)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CCL5 (CCL5/RANTES)  
     OriGene Antibodies for CCL5   OriGene RNAi products in human, mouse, rat for CCL5  
     OriGene qPCR primer pairs and template standards for CCL5   OriGene Protein Over-expression Lysate for CCL5  
     OriGene MassSpec something-or-other for CCL5   OriGene clones in human, mouse for CCL5  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCL5   OriGene Purified Protein for CCL5  
     OriGene ORF clones in mouse, rat for CCL5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCL5   OriGene Custom Protein Services for CCL5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL5
     QIAGEN SeqTarget long-range PCR primers for resequencing CCL5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL5
     GenScript Purified and Recombinant Proteins for CCL5 GenScript cDNA clones with any tag delivered in your preferred vector for CCL5
     GenScript Custom Assay Services for CCL5 GenScript Superior Antibodies for CCL5
     GenScript Custom overexpressing Cell Line Services for CCL5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CCL5 

     Regulatory tfbs in CCL5 promoter
     Search Chromatin IP Primers for CCL5
     RT2 qPCR Primer Assay in human, mouse, rat CCL5
     GNC Network for CCL5
     SABiosciences PCR Arrays including human, mouse, rat CCL5
     Search Tocris compounds for CCL5
     Proteins and Antibodies for CCL5
     Cell Lysates for CCL5
     cDNA Clones for CCL5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCL5 antibodies
     CCL5 proteins
     CCL5 lysates
     Antibodies for CCL5
     See all of Abcam's Antibodies, Kits and Proteins for CCL5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CCL5




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CCL5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5
     SwitchGear 3'UTR luciferase reporter plasmids for CCL5
     SwitchGear Promoter luciferase reporter plasmids for CCL5
     ThermoFisher Antibody for CCL5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL5
    Customized:
     lentivirus for stable overexpression of CCL5
     lentivirus expression plasmids for stable overexpression of CCL5
     adenovirus for overexpression of CCL5
     LSBio Antibodies in human, mouse, rat for CCL5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCL5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4