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Aliases &
Descriptions
for CCL5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| D17S136E 2, 3, 5 | | EoCP 3 | | MGC17164 1, 2 | | RANTES 1, 2 | | SCYA5 2, 3, 5 | | SIS-delta 2, 3 | | SISd 1, 2 | | TCP228 1, 2, 3, 5 |
| | | Descriptions |
|---|
| Eosinophil-chemotactic cytokine 3 | | Small-inducible cytokine A5 3 | | T cell-specific protein P228 3 | | T-cell specific RANTES protein 2 | | T-cell specific protein p288 2 | | T-cell-specific protein RANTES 3 | | beta-chemokine RANTES 2 | | chemokine (C-C motif) ligand 5 2 | regulated upon activation, normally T-expressed, and
presumably secreted 2 | | small inducible cytokine A5 2 | | small inducible cytokine A5 (RANTES) 1, 2 | | small inducible cytokine subfamily A (Cys-Cys), member 5 2 |
|
| |
Search outside databases for aliases for CCL5 genePrevious GC identifers: GC17M033968 GC17M036234 GC17M034344 |
Summaries
for CCL5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CCL5:
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines
are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC
cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene
functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It
causes the release of histamine from basophils and activates eosinophils. This cytokine is one of
the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural
ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains
of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq]
UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the
release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5.
One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein
induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian
immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis
inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form
RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68)
and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and
neutrophilsGene Wiki entry for CCL5 |
Genomic Location
for CCL5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the CCL5 gene 
Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12CCL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M031222:
(about GC identifiers)
Start:
|
31,222,608 bp from pter |
End:
|
31,231,910 bp from pter |
Size:
|
9,303 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010799.14
| Proteins
for CCL5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501 (See
protein sequence)Recommended Name: C-C motif chemokine 5 precursor Size: 91 amino acids; 9990 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7515; Mass_error=1; Method=SELDI; Range=27-91; Source=PubMed:15923218;
Mass spectrometry: Mass=7862.8; Mass_error=1.1; Method=Electrospray; Range=24-91;
Source=PubMed:1380064;
Mass spectrometry: Mass=8355; Mass_error=10; Method=Electrospray; Range=24-91; Note=O-glycosylated;
Source=PubMed:1380064;
PDB structures from  and Proteopedia  :1B3A (3D)
1EQT (3D)
1HRJ (3D)
1RTN (3D)
1RTO (3D)
1U4L (3D)
1U4M (3D)
1U4P (3D)
1U4R (3D)
2VXW (3D)
Secondary accessions: O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99Post-translational modifications:
N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after
secretion from peripheral blood leukocytes and cultured sarcoma cells1
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064.
They are assigned by similarity1
REFSEQ proteins: NP_002976.2
ENSEMBL proteins: ENSP00000293272 ENSP00000375216
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CCL5:
Assays for CCL5: | Protein
Domains/
Families
for CCL5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P13501
ProtoNet protein and cluster: P13501 1 Blocks protein family: IPB000827 Small chemokine
UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501Similarity: Belongs to the intercrine beta (chemokine CC) family | Gene Function
for CCL5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002985
 Applied Biosystems Silencer® siRNAs for CCL5
 Sigma-Aldrich siRNA and siRNA Panels for CCL5
Sigma-Aldrich shRNA Panels and shRNA for CCL5
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002985
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002985
untagged cDNA clones in CMV expression vector (see all 7): AK092450
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: AK098099
UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the
release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5.
One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein
induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian
immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis
inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form
RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68)
and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and
neutrophilsInduction: By mitogens2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccl5):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for CCL5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for CCL5 (Your Favorite Gene powered by Ingenuity) (see all 7
)
Gene Network CentralTM Interacting Genes and Proteins Network for CCL5
5/146 Interacting proteins for CCL5 (ENSP000002932723) via UniProtKB, MINT, and/or STRING (see all 146
)About this table
5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14
): About this table
|
Drugs & Compounds
for CCL5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CCL5
10/52  Novoseek chemical compound relationships for CCL5 gene (see all 52
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rantes |
99.38 |
5469 |
11435978 (13), 9192918 (13), 10336000 (12), 15794069 (12) (see all 99) |
| ccl3 |
87.09 |
101 |
16197470 (5), 14761932 (3), 15111638 (2), 12010572 (2) (see all 61) |
| tarc |
81.39 |
27 |
17460400 (2), 9169480 (2), 18691293 (2), 15941911 (1) (see all 23) |
| groalpha |
78.42 |
21 |
16869002 (4), 10337033 (2), 16047084 (2), 15975968 (2) (see all 15) |
| mip 1alpha |
77.15 |
11 |
18403790 (3), 10820198 (1), 11097208 (1), 16211583 (1) (see all 9) |
| mcp 4 |
71.42 |
1 |
10640766 (1) |
| mcp 2 |
69.45 |
2 |
16323127 (1), 10364178 (1) |
| ccl4 |
65.95 |
75 |
14761932 (2), 12960247 (2), 15634233 (2), 18223665 (2) (see all 45) |
| ena 78 |
63.00 |
1 |
11503269 (1) |
| mcp 3 |
61.81 |
2 |
7545673 (2) |
About this table
1 PharmGKB drug compound relationship for CCL5 geneAbout this table
|
Transcripts
for CCL5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002985
Sigma-Aldrich siRNA and siRNA Panels for CCL5
Sigma-Aldrich shRNA Panels and shRNA for CCL5
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002985 REFSEQ mRNAs for CCL5 gene: NM_002985.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002985
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002985
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002985
untagged cDNA clones in CMV expression vector (see all 7): AK092450
Additional cDNA sequence: AF043341.1 AF266753.1 AK312212.1 BC008600.1 DQ230537.1 M21121.1 4 DOTS entries: DT.412343 DT.97862489 DT.87014719 DT.120906134 1 AceView cDNA sequence:BF996938
 highest scoring ESTs for CCL5:M21121 AA361990 AA362307 AF266753 AV684977 AV733872 AV735059 AW800229 BC008600 BF965414 Unigene Cluster for CCL5: Chemokine (C-C motif) ligand 5 Hs.514821 [show with all ESTs]Unigene Representative Sequence: BM917378
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL5
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | |
About this scheme
ECgene alternative splicing isoforms for CCL5
2 Ensembl transcripts including schematic representations: ENST00000293272
ENST00000366113
|
Expression
for CCL5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CCL5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CCL5
1 / 2 / 3 8 probe-sets matching CCL5 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAAAATCGGC
SOURCE GeneReport for Unigene cluster: Hs.514821
Expression variation in blood from EXPOLDB for CCL5 UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501Tissue specificity: T-cell and macrophage specific |
Orthologs
for CCL5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CCL5 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for CCL5
ENSEMBL Gene Tree for CCL5 | Paralogs
for CCL5(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CCL5 gene
- ENSG000002156272 CCL142 CCL4L12 CCL4L22 CCL3L12 CCL32 CCL3L32 LOC7288302
- CCL42 CCL182
|
SNPs/Variants
for CCL5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501Polymorphism: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3
HapMap Linkage Disequilibrium images for CCL5 (up to first 250kb)
|
Disorders & Mutations
for CCL5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 187011 10/96 Novoseek disease relationships for CCL5 gene (see all 96
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
76.04 |
78 |
15740484 (2), 10606930 (2), 17711627 (2), 17164972 (2) (see all 70) |
| necrosis |
66.34 |
168 |
9003213 (2), 16413378 (2), 11330934 (2), 19291322 (2) (see all 99) |
| nasal polyps |
59.76 |
33 |
14687706 (4), 16903328 (4), 16456693 (3), 10942140 (3) (see all 17) |
| immunodeficiency |
59.39 |
41 |
10979927 (2), 10364494 (2), 10196243 (2), 9359702 (1) (see all 34) |
| asthma |
58.61 |
68 |
17678722 (4), 8970374 (3), 11197694 (3), 17990036 (3) (see all 40) |
| eosinophilia |
55.52 |
18 |
12853519 (2), 15794069 (2), 12388374 (1), 11398366 (1) (see all 14) |
| hiv infections |
55.50 |
29 |
10917892 (2), 17671228 (2), 12634395 (2), 16437690 (2) (see all 22) |
| asthma allergic |
47.84 |
6 |
8626989 (2), 15592421 (1), 8980953 (1), 18716401 (1) (see all 5) |
| virus infection |
47.30 |
38 |
8977509 (3), 10364494 (3), 12388374 (2), 10799898 (2) (see all 26) |
| dermatitis atopic |
46.66 |
22 |
17117952 (6), 8906106 (3), 15948978 (2), 10444253 (1) (see all 13) |
About this table
Human Gene Mutation Database: CCL5
Genetic Association Database: CCL5
Human Genome Epidemiology Navigator: CCL5 (128 documents)
|
Medical News
for CCL5(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for CCL5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1638 PubMed articles for CCL5 gene (see all 1638
):- RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection. (PubMed id 15978191)1, 3, 6 Duan Z.P....Zheng B.J. (2005)
- Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. (PubMed id 15368437)1, 3, 6 Wasmuth H.E....Lammert F. (2004)
- The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. (PubMed id 15863470)1, 3, 6 Goulding C....Kelleher D. (2005)
- RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. (PubMed id 12610055)1, 3, 6 Nakajima K....Kawamori R. (2003)
- Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain. (PubMed id 12837926)1, 3, 6 Antinolo G....Molini J.L. (2003)
- Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population. (PubMed id 11844139)1, 3, 6 Takada T....Gejyo F. (2001)
- The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. (PubMed id 11197694)1, 3, 6 Fryer A.A....Hajeer A.H. (2000)
- Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 3, 4 Nomiyama H.... Yoshie O. (1999)
- RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese. (PubMed id 15971427)1, 3, 6 Wang C.R....Liu M.F. (2005)
- Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. (PubMed id 16024972)1, 3, 6 Moissidis I....Bahna S.L. (2005)
|
Search for CCL5
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCL5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CCL5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCL5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/ccl5/ | | Wikipedia | http://en.wikipedia.org/wiki/RANTES |
|
| | | About This Section
| --
| Services
for CCL5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for CCL5:
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