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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL5 Gene

protein-coding   GIFtS: 68
GCID: GC17M034198

chemokine (C-C motif) ligand 5

(Previous name: small inducible cytokine A5 (RANTES) )
(Previous symbols: D17S136E, SCYA5)
 Explore 232 diseases affiliated with
CCL5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL5    

Aliases
for CCL5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 51 2     SIS-Delta1
D17S136E1 2 3 5     T-Cell-Specific Protein RANTES2 3
SCYA51 2 3 5     MGC171641
TCP2281 2 3 5     Beta-Chemokine RANTES2
RANTES1 2     C-C Motif Chemokine 52
SISd1 2     EoCP3
Small Inducible Cytokine A5 (RANTES)1 2     Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted2
Eosinophil Chemotactic Cytokine2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 52
Small-Inducible Cytokine A52 3     T-Cell Specific Protein P2882
T Cell-Specific Protein P2282 3     EoCP3

External Ids:    HGNC: 106321   Entrez Gene: 63522   Ensembl: ENSG000001615707   OMIM: 1870115   UniProtKB: P135013   

Export aliases for CCL5 gene to outside databases

Previous GC identifers: GC17M033968 GC17M036234 GC17M034344 GC17M031222 GC17M030383


Summaries
for CCL5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL5:
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes,
memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils.
This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural
ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use
CCR5 as a coreceptor. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine
from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors
produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of
HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis
inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced
chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an
unidentified enzyme associated with monocytes and neutrophils

Gene Wiki entry for CCL5


Genomic Views
for CCL5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL5 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

CCL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034198:  view genomic region     (about GC identifiers)

Start:
 34,198,495 bp from pter      End:
 34,207,797 bp from pter
Size:
 9,303 bases      Orientation:
 minus strand

Proteins
for CCL5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501 (See protein sequence)
Recommended Name: C-C motif chemokine 5 precursor  
Size: 91 amino acids; 9990 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7515; Mass_error=1; Method=SELDI; Range=27-91; Source=PubMed:15923218;
Mass spectrometry: Mass=7862.8; Mass_error=1.1; Method=Electrospray; Range=24-91; Source=PubMed:1380064;
Mass spectrometry: Mass=8355; Mass_error=10; Method=Electrospray; Range=24-91; Note=O-glycosylated;
Source=PubMed:1380064;
6/11 PDB 3D structures from and Proteopedia for CCL5 (see all 11):
1B3A (3D)        1EQT (3D)        1HRJ (3D)        1RTN (3D)        1RTO (3D)        1U4L (3D)    
Secondary accessions: O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99

Explore the universe of human proteins at neXtProt for CCL5: NX_P13501

Post-translational modifications:

  • N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from
    • peripheral blood leukocytes and cultured sarcoma cells1
  • The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by
    • similarity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13501

    • CCL5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002976.2  
    ENSEMBL proteins: 
     ENSP00000293272   ENSP00000375216   ENSP00000465234  
    Reactome Protein details: P13501
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CCL5 Protein
    R&D Systems Recombinant & Natural Proteins for CCL5 (CCL5/RANTES)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CCL5
    OriGene Protein Over-expression Lysate: CCL5
    OriGene Custom Protein Services for CCL5 
    GenScript Purified and Recombinant Proteins for CCL5
    Novus Biologicals CCL5 Proteins
    Novus Biologicals CCL5 Lysates
    Sino Biological Recombinant Protein for CCL5
    ProSpec Recombinant Protein for CCL5
    Uscn Proteins for CCL5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IEA--


    CCL5 for ontologies           About GeneDecksing



    CCL5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL5
    R&D Systems Antibodies for CCL5 (CCL5/RANTES)
    Cell Signaling Technology (CST) Antibodies for CCL5 
    OriGene Antibodies: CCL5
    OriGene Custom Antibody Services for CCL5 
    GenScript Superior Antibodies for CCL5
    Novus Biologicals CCL5 Antibodies
    Abcam antibodies for CCL5 
    Uscn Antibodies for CCL5
    ThermoFisher Antibody for CCL5

    Assay Products for CCL5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for CCL5 (CCL5/RANTES)         (see all)
    GenScript Custom Assay Services for CCL5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCL5

    Protein Domains /
    Families
    for CCL5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCL5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P13501

    ProtoNet protein and cluster: P13501

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Function
    for CCL5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine
    from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors
    produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of
    HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis
    inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced
    chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an
    unidentified enzyme associated with monocytes and neutrophils
    Induction: By mitogens

    miRNA
    Products:            		miRTarBase miRNAs that target CCL5:
    hsa-mir-98 (MIRT005677), hsa-mir-125a-5p (MIRT005678)

    OriGene 3'-UTR Clone: CCL5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: CCL5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL5 (see all 7)
    OriGene shRNA RFP: CCL5
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCL5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    Sino Biological Human cDNA Clone for CCL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCL5
    Search LifeMap BioReagents cell lines for CCL5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL5

    Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IDA10734056
    GO:0004672protein kinase activity IDA10734056
    GO:0005515protein binding IPI8699119
    GO:0008009chemokine activity NAS7524281
    GO:0008201heparin binding ----


    CCL5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ccl5tm1Hso for CCL5
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccl5):
     cellular  hematopoietic system  immune system 

    CCL5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCL5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CCL5
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL5 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for CCL5
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for CCL5
        Cell adhesion Cell-matrix glycoconjugates
    Immune response CCR3 signaling in eosinophils

    5/6 BioSystems Pathways for CCL5 (see all 6) 
        EBV LMP1 signaling
    TWEAK Signaling Pathway
    Toll-like receptor signaling pathway
    Validated targets of C-MYC transcriptional repression
    Syndecan-4-mediated signaling events

    5/8        Reactome Pathways for CCL5 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    5/10         Kegg Pathways  (Kegg details for CCL5) (see all 10):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    CCL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for CCL5 (P135012, 3 ENSP000002932724) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR5P516812, 3, ENSP000002923034MINT-8416147 MINT-8416085 MINT-8416125 MINT-8416173 I2D: score=3 STRING: ENSP00000292303
    DPP4P274872, 3, ENSP000003537314MINT-8090927 I2D: score=2 STRING: ENSP00000353731
    CCBP2O005903, ENSP000002731454I2D: score=4 STRING: ENSP00000273145
    CCR1P322463, ENSP000002961404I2D: score=4 STRING: ENSP00000296140
    VCANP136113, ENSP000002650774I2D: score=4 STRING: ENSP00000265077
    About this table

    Gene Ontology (GO): 5/97 biological process terms (GO ID links to tree view) (see all 97):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0002407dendritic cell chemotaxis TAS18337562
    GO:0002544chronic inflammatory response ----
    GO:0002548monocyte chemotaxis IC10660125
    GO:0002676regulation of chronic inflammatory response TAS10488085


    CCL5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCL5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL5

    2 DrugBank Compounds for CCL5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heparin Disaccharide I-S-- --target--17139284 17016423
    Heparin Disaccharide Iii-S-- --target--17139284 17016423

    10/117 Novoseek chemical compound relationships for CCL5 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 99.4 5828 11435978 (13), 9192918 (13), 10336000 (12), 15794069 (12) (see all 99)
    ccl3 87.5 120 16197470 (5), 14761932 (3), 19906920 (2), 20205697 (2) (see all 72)
    tarc 80.3 27 17460400 (2), 9169480 (2), 18691293 (2), 15941911 (1) (see all 23)
    groalpha 79.7 24 16869002 (4), 10337033 (2), 16047084 (2), 19497617 (2) (see all 17)
    mip 1alpha 77.9 16 18403790 (3), 20205697 (2), 10820198 (1), 16211583 (1) (see all 11)
    mcp 4 70.8 1 10640766 (1)
    ccl4 67.2 83 14761932 (2), 12960247 (2), 20046229 (2), 18223665 (2) (see all 52)
    mcp 2 67.1 2 16323127 (1), 10364178 (1)
    ena 78 65.1 1 11503269 (1)
    mcp 1 64.3 9 20205697 (2), 10559777 (2), 16918500 (1), 20332253 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CCL5 

    Transcripts
    for CCL5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCL5 gene: 
    NM_002985.2  

    Unigene Cluster for CCL5:

    Chemokine (C-C motif) ligand 5
    Hs.514821  [show with all ESTs]
    Unigene Representative Sequence: BM917378
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293272(uc002hkf.3) ENST00000366113 ENST00000463941

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCL5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL5:
    hsa-miR-617 hsa-miR-3667-3p hsa-miR-150 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: CCL5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL5 (see all 7)
    OriGene shRNA RFP: CCL5
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL5 (NM_002985)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL5

    Additional cDNA sequence: 

    AF043341.1 AF266753.1 AK312212.1 BC008600.1 DQ230537.1 M21121.1 

    4 DOTS entries:

    DT.412343  DT.97862489  DT.87014719  DT.120906134 

    1 AceView cDNA sequence:

    BF996938 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CCL5

    Expression
    for CCL5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAATCGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCL5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL5

    SOURCE GeneReport for Unigene cluster: Hs.514821

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Tissue specificity: T-cell and macrophage specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL5 (see all 25): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              Endothelial Cell Biology in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL5
    Browse OriGene validated miRNA SYBR primer pairs
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    In Situ
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    Orthologs
    for CCL5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCL5 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCL51 chemokine (C-C motif) ligand 5 64.04(n)
    58.43(a)    		   417465  NM_001045832.1  NP_001039297.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1937066
    si:dkeyp-59a8.16
    (see all 6)    		 si:dkeyp-59a8.1
    (see all 6)    		 29(a)
    23(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 25(25902180-25904281)
    20(38282475-38302293)


    ENSEMBL Gene Tree for CCL5 (if available)
    TreeFam Gene Tree for CCL5 (if available) 

    Paralogs
    for CCL5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL5 gene
    CCL152  CCL162  CCL22  CCL142  CCL242  CCL4L12  CCL112  CCL4L22  
    CCL72  CCL3L12  CCL232  CCL3L32  CCL42  CCL82  CCL132  CCL262  
    CCL32  CCL182  
    18/30 SIMAP similar genes for CCL5 using alignment to 3 protein entries:     CCL5_HUMAN (see all proteins) (see all similar genes):
    CCL4    CCL15    CCL24    CCL4L2    LOC728835    CCL3L1
    CCL3L3    CCL4L1    CCL3    CCL26    CCL14    MCP-3
    CCL18    CCL13    CCL8    CCL7    CCL22    CCL16

    CCL5 for paralogs           About GeneDecksing



    Genomic Variants
    for CCL5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CCL5_HUMAN, P13501
    Polymorphism: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3


    10/189 NCBI SNPs in CCL5 are shown (see all 189)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289148151,2
    		C--30383510(-) ACCATA/GAAGCT 1 -- ut317Minor allele frequency- G:0.00NS NA 194
    rs289148141,2
    		C,F,H,--30383587(-) CTTCCG/ACCGTC 1 -- ut31 ese311Minor allele frequency- A:0.02NS NA 764
    rs10653411,2
    		C,F,H,--30383606(-) GGAACA/GCTGCA 1 -- ut31 ese329Minor allele frequency- G:0.13MN NA NS EA CSA WA 2525
    rs413702461,2
    		C,--30383887(+) CCGAGC/TAGCTG 1 -- ut310--------
    rs289148121,2
    		C,F,--30384651(-) GATGAG/AGAAAT 1 -- int17Minor allele frequency- A:0.02NS NA 312
    rs1122935821,2
    		C,--30384693(+) AATTTC/GTGTGC 1 -- int10--------
    rs750620431,2
    		--30384708(+) TAATCG/TCCTTC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs415162461,2
    		C,--30384850(+) AGAGAA/TTAAGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs289148091,2
    		C,--30385484(-) GCTCAT/CGCCTG 1 -- int15Minor allele frequency- C:0.01NS 184
    rs414101451,2
    		C,--30387192(+) TATGCA/GTGTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCL5 (34198495 - 34207797 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCL5: --
    Human Gene Mutation Database (HGMD): CCL5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL5

    Disorders / Diseases
    for CCL5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCL5 for disorders           About GeneDecksing

    OMIM gene information: 187011    OMIM disorders: --

    20/232 diseases for CCL5 (see all 232):    About MalaCards
    african tick-bite fever    hiv-1 disease, rapid progression of    hiv-1 disease, delayed progression of    graft versus host disease
    polymyalgia rheumatica    relapsing-remitting multiple sclerosis    periapical granuloma    toxic epidermal necrolysis
    otitis media    stevens-johnson syndrome    subacute sclerosing panencephalitis    hypersensitivity reaction type ii disease
    lichen planus    complex regional pain syndrome    human immunodeficiency virus infectious disease    west nile virus
    griscelli syndrome type 2    sclerosing cholangitis    ulcer of lower limbs    griscelli syndrome

    2 diseases from the University of Copenhagen DISEASES database for CCL5:
    Asthma     Encephalitis

    10/97 Novoseek disease relationships for CCL5 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 76.3 84 15740484 (2), 20459697 (2), 10606930 (2), 16449815 (2) (see all 74)
    necrosis 66.6 180 9003213 (2), 16413378 (2), 11330934 (2), 19291322 (2) (see all 99)
    asthma 59.3 83 17678722 (4), 8970374 (3), 20430255 (3), 11197694 (3) (see all 44)
    nasal polyps 58.7 39 14687706 (4), 16903328 (4), 19522185 (4), 16456693 (3) (see all 18)
    immunodeficiency 58.4 41 10979927 (2), 10364494 (2), 10196243 (2), 9359702 (1) (see all 34)
    hiv infections 55.3 32 10917892 (2), 17671228 (2), 12634395 (2), 16437690 (2) (see all 25)
    eosinophilia 55.2 19 12853519 (2), 15794069 (2), 12388374 (1), 11398366 (1) (see all 15)
    asthma allergic 49.2 7 8626989 (2), 15592421 (1), 20430255 (1), 18716401 (1) (see all 6)
    virus infection 47 39 8977509 (3), 10364494 (3), 12388374 (2), 10799898 (2) (see all 27)
    dermatitis atopic 45.6 22 17117952 (6), 8906106 (3), 15948978 (2), 10444253 (1) (see all 13)

    Genetic Association Database (GAD): CCL5
    Human Genome Epidemiology (HuGE) Navigator: CCL5 (177 documents)

    Export disorders for CCL5 gene to outside databases

    Publications
    for CCL5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL5 gene, integrated from 9 sources (see all 1902):
    (articles sorted by number of sources associating them with CCL5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection. (PubMed id 15978191)1, 4, 9 Duan Z.P....Zheng B.J. (2005)
    2. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. (PubMed id 15368437)1, 4, 9 Wasmuth H.E....Lammert F. (2004)
    3. RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. (PubMed id 12610055)1, 4, 9 Nakajima K....Kawamori R. (2003)
    4. Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain. (PubMed id 12837926)1, 4, 9 Antinolo G....Molini J.L. (2003)
    5. Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population. (PubMed id 11844139)1, 4, 9 Takada T....Gejyo F. (2001)
    6. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. (PubMed id 11197694)1, 4, 9 Fryer A.A....Hajeer A.H. (2000)
    7. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (1999)
    8. RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese. (PubMed id 15971427)1, 4, 9 Wang C.R....Liu M.F. (2005)
    9. Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. (PubMed id 16024972)1, 4, 9 Moissidis I....Bahna S.L. (2005)
    10. RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children. (PubMed id 15715189)1, 4, 9 Leung T.F....Wong G.W. (2005)

    External Searches for CCL5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCL5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6352 HGNC: 10632 AceView: CCL5.1 Ensembl:ENSG00000161570 euGenes: HUgn6352
    ECgene: CCL5 Kegg: 6352 H-InvDB: CCL5

    Other Databases showing CCL5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCL5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccl5/
    Wikipedia http://en.wikipedia.org/wiki/RANTES

    Intellectual Property
    for CCL5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCL5 gene:
    Search GeneIP for patents involving CCL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCL5 gene

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    About This Section

     Browse Kits and Assays available from EMD Millipore
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