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Aliases for CCL4L2 Gene

Aliases for CCL4L2 Gene

  • Chemokine (C-C Motif) Ligand 4-Like 2 2
  • SCYA4L1 3 4
  • LAG-1 3 4
  • CCL4L 3 4
  • LAG1 3 4
  • Chemokine (C-C Motif) Ligand 4-Like 1, Telomeric 3
  • Monocyte Adherence-Induced Protein 5-Alpha 4
  • Macrophage Inflammatory Protein 1-Beta 4
  • Chemokine (C-C Motif) Ligand 4-Like 1 3
  • Lymphocyte Activation Gene 1 Protein 4
  • Macrophage Inflammatory Protein-1b2 3
  • Small Inducible Cytokine A4-Like 3
  • Small-Inducible Cytokine A4-Like 4
  • Lymphocyte Activation Gene 1 3
  • C-C Motif Chemokine 4-Like 3
  • CC Chemokine Ligand 4L1 3
  • CCL4L1 CCL4L2 4
  • MIP-1-Beta 4
  • AT744.2 3
  • SCYA4L2 4
  • SCYA4L 3
  • CCL4L1 3

External Ids for CCL4L2 Gene

Previous GeneCards Identifiers for CCL4L2 Gene

  • GC17P031665
  • GC17P034639

Summaries for CCL4L2 Gene

Entrez Gene Summary for CCL4L2 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L2 Gene

CCL4L2 (Chemokine (C-C Motif) Ligand 4-Like 2) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling.

UniProtKB/Swiss-Prot for CCL4L2 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L2 Gene

Genomics for CCL4L2 Gene

Regulatory Elements for CCL4L2 Gene

Genomic Location for CCL4L2 Gene

Start:
266,769 bp from pter
End:
268,576 bp from pter
Size:
1,808 bases
Orientation:
Plus strand

Genomic View for CCL4L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for CCL4L2 Gene

Proteins for CCL4L2 Gene

  • Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHW4-CC4L_HUMAN
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Q8NHW4
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L2 Gene

    Size:
    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L2 Gene

neXtProt entry for CCL4L2 Gene

Proteomics data for CCL4L2 Gene at MOPED

Post-translational modifications for CCL4L2 Gene

No Post-translational modifications

Other Protein References for CCL4L2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for CCL4L2 Gene

Domains for CCL4L2 Gene

Gene Families for CCL4L2 Gene

HGNC:
  • CCL :Chemokine ligands

Protein Domains for CCL4L2 Gene

Suggested Antigen Peptide Sequences for CCL4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHW4

UniProtKB/Swiss-Prot:

CC4L_HUMAN :
  • Q8NHW4
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4L2: view

Function for CCL4L2 Gene

Molecular function for CCL4L2 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Phenotypes for CCL4L2 Gene

GenomeRNAi human phenotypes for CCL4L2:
genes like me logo Genes that share phenotypes with CCL4L2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL4L2 Gene

Localization for CCL4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL4L2 Gene COMPARTMENTS Subcellular localization image for CCL4L2 gene
Compartment Confidence
extracellular 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CCL4L2 Gene

Transcripts for CCL4L2 Gene

Unigene Clusters for CCL4L2 Gene

Chemokine (C-C motif) ligand 4-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL4L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L2 Gene

No ASD Table

Relevant External Links for CCL4L2 Gene

GeneLoc Exon Structure for
CCL4L2
ECgene alternative splicing isoforms for
CCL4L2

Expression for CCL4L2 Gene

mRNA expression in normal human tissues for CCL4L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene

This gene is overexpressed in Whole Blood (12.6) and Spleen (4.6).

SOURCE GeneReport for Unigene cluster for CCL4L2 Gene Hs.449862

mRNA Expression by UniProt/SwissProt for CCL4L2 Gene

Q8NHW4-CC4L_HUMAN
Tissue specificity: Detected in B-cells.
genes like me logo Genes that share expressions with CCL4L2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CCL4L2 Gene

Orthologs for CCL4L2 Gene

No data available for Orthologs and Evolution for CCL4L2 Gene

Paralogs for CCL4L2 Gene

Selected SIMAP similar genes for CCL4L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL4L2: view

No data available for Paralogs for CCL4L2 Gene

Variants for CCL4L2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene

Q8NHW4-CC4L_HUMAN
The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome

Sequence variations from dbSNP and Humsavar for CCL4L2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs147970464 -- 1(+) AGGAC(A/G/T)GTGGC upstream-variant-2KB
rs151202755 -- 1(+) GTCTG(C/G/T)GCTGA reference, missense, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL4L2 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv514838 CNV Complex 21397061
nsv436845 CNV Insertion 17901297
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv514839 CNV Complex 21397061

Relevant External Links for CCL4L2 Gene

HapMap Linkage Disequilibrium report
CCL4L2

Disorders for CCL4L2 Gene

Relevant External Links for CCL4L2

Genetic Association Database (GAD)
CCL4L2

No disorders were found for CCL4L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CCL4L2 Gene

Publications for CCL4L2 Gene

  1. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4
  2. Functional redundancy of the human CCL4 and CCL4L1 chemokine genes. (PMID: 15240137) Howard O.M.Z. … Modi W.S. (Biochem. Biophys. Res. Commun. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4
  5. The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1. (PMID: 11685466) Modi W.S. … Sanford M. (Immunogenetics 2001) 3 4

Products for CCL4L2 Gene

Sources for CCL4L2 Gene

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