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Aliases for CCL4L2 Gene

Aliases for CCL4L2 Gene

  • C-C Motif Chemokine Ligand 4 Like 2 2 3 5
  • Monocyte Adherence-Induced Protein 5-Alpha 3 4
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Chemokine (C-C Motif) Ligand 4-Like 2 2 3
  • MIP-1-Beta 3 4
  • CCL4L 3 4
  • Lymphocyte Activation Gene 1 Protein 4
  • Macrophage Inflammatory Protein-1b2 3
  • Small Inducible Cytokine A4-Like 3
  • Small-Inducible Cytokine A4-Like 4
  • C-C Motif Chemokine 4-Like 3
  • CCL4L1 CCL4L2 4
  • AT744.2 3
  • SCYA4L1 4
  • SCYA4L2 4
  • SCYQ4L2 3
  • SCYA4L 3
  • LAG-1 4
  • LAG1 4

External Ids for CCL4L2 Gene

Previous GeneCards Identifiers for CCL4L2 Gene

  • GC17P031665
  • GC17P034639
  • GC17Pj00266

Summaries for CCL4L2 Gene

Entrez Gene Summary for CCL4L2 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L2 Gene

CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Salmonella infection (KEGG). An important paralog of this gene is CCL4.

UniProtKB/Swiss-Prot for CCL4L2 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Wiki entry for CCL4L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L2 Gene

Genomics for CCL4L2 Gene

Regulatory Elements for CCL4L2 Gene

Enhancers for CCL4L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036589 1.4 FANTOM5 ENCODE 5 +385.6 385598 13.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 SP5 ZNHIT3 MYO19 ENSG00000274756 CCL4L2 DHRS11 GC17P036615 MRM1
GH17F036528 0.9 ENCODE 7.6 +318.1 318090 0.9 HDAC1 TBL1XR1 ARNT ZNF766 GATA2 FOS CREM ZBTB2 ZBTB11 JUNB CCL4L2 GC17M036531 PIR53886
GH17F036154 0.5 FANTOM5 7.4 -56.5 -56452 0.4 ZNF316 TBX21 CCL4 CCL3 CCL3L3 CCL4L2 CCL5 CCL23 GGNBP2 ENSG00000282738 LOC100420851 LOC101927369
GH17F036215 0.7 Ensembl 0.8 +4.6 4578 0.2 SCRT1 CTCF ZNF654 TRIM22 REST RAD21 ZKSCAN1 ZSCAN16 SCRT2 SMC3 CCL4L2 ENSG00000278097
GH17F036209 0.6 Ensembl 0.8 +0.9 877 4.8 ZFP64 ZBTB11 ZBTB8A ZNF623 ZNF518A ZNF781 ZBTB40 ENSG00000267321 CCL4L2 ENSG00000278097
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL4L2 Gene

Chromosome:
17
Start:
36,210,924 bp from pter
End:
36,212,878 bp from pter
Size:
1,955 bases
Orientation:
Plus strand

Genomic View for CCL4L2 Gene

Genes around CCL4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4L2 Gene

Proteins for CCL4L2 Gene

  • Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHW4-CC4L_HUMAN
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Q8NHW4
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L2 Gene

    Size:
    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L2 Gene

neXtProt entry for CCL4L2 Gene

Post-translational modifications for CCL4L2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCL4L2 Gene

Domains & Families for CCL4L2 Gene

Gene Families for CCL4L2 Gene

Protein Domains for CCL4L2 Gene

Suggested Antigen Peptide Sequences for CCL4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHW4

UniProtKB/Swiss-Prot:

CC4L_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4L2: view

Function for CCL4L2 Gene

Molecular function for CCL4L2 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Ontology (GO) - Molecular Function for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

Phenotypes for CCL4L2 Gene

GenomeRNAi human phenotypes for CCL4L2:
genes like me logo Genes that share phenotypes with CCL4L2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L2 Gene

Localization for CCL4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL4L2 gene
Compartment Confidence
extracellular 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL4L2: view

Pathways & Interactions for CCL4L2 Gene

genes like me logo Genes that share pathways with CCL4L2: view

Interacting Proteins for CCL4L2 Gene

Gene Ontology (GO) - Biological Process for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0030593 neutrophil chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for SIGNOR curated interactions for CCL4L2 Gene

Transcripts for CCL4L2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L2 Gene

No ASD Table

Relevant External Links for CCL4L2 Gene

GeneLoc Exon Structure for
CCL4L2
ECgene alternative splicing isoforms for
CCL4L2

Expression for CCL4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL4L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of CCL4L2 Gene:

CCL4L2

mRNA Expression by UniProt/SwissProt for CCL4L2 Gene:

Q8NHW4-CC4L_HUMAN
Tissue specificity: Detected in B-cells.
genes like me logo Genes that share expression patterns with CCL4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL4L2 Gene

Orthologs for CCL4L2 Gene

Evolution for CCL4L2 Gene

ENSEMBL:
Gene Tree for CCL4L2 (if available)
TreeFam:
Gene Tree for CCL4L2 (if available)

No data available for Orthologs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

genes like me logo Genes that share paralogs with CCL4L2: view

Variants for CCL4L2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene

CC4L_HUMAN-Q8NHW4
The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.

Sequence variations from dbSNP and Humsavar for CCL4L2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1049745 -- 36,210,966(-) GATGA(C/T)GTCAT upstream-variant-2KB
rs141559159 -- 36,212,499(+) AAGAG(G/T)CAAGC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs142100639 -- 36,210,667(+) TTGTT(C/T)TTGGG upstream-variant-2KB
rs145075645 -- 36,210,360(+) TGAGC(A/G)CCATC upstream-variant-2KB
rs145886395 -- 36,211,278(+) TTCTA(G/T)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL4L2 Gene

Variant ID Type Subtype PubMed ID
nsv960473 CNV duplication 23825009
nsv960470 CNV duplication 23825009
nsv953882 CNV deletion 24416366
nsv833427 CNV loss 17160897
nsv820772 CNV deletion 20802225
nsv574788 CNV gain+loss 21841781
nsv574783 CNV gain 21841781
nsv574781 CNV gain 21841781
nsv574780 CNV gain+loss 21841781
nsv574755 CNV gain 21841781
nsv517262 CNV gain+loss 19592680
nsv514838 CNV gain 21397061
nsv514836 CNV gain 21397061
nsv471396 CNV gain 19718026
nsv457733 CNV gain 19166990
nsv433448 CNV gain 18776910
nsv2040 CNV deletion 18451855
nsv1160468 CNV duplication 26073780
nsv1143852 CNV deletion 24896259
nsv1133405 CNV deletion 24896259
nsv1072731 CNV deletion 25765185
nsv1062304 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1061066 CNV loss 25217958
nsv1059795 CNV gain 25217958
nsv1059497 CNV gain+loss 25217958
esv3893005 CNV loss 25118596
esv3893002 CNV loss 25118596
esv3893001 CNV gain 25118596
esv3893000 CNV gain+loss 25118596
esv3554365 CNV deletion 23714750
esv3450833 CNV duplication 20981092
esv3441237 CNV duplication 20981092
esv3345949 CNV duplication 20981092
esv33107 CNV loss 17666407
esv2762388 CNV gain+loss 21179565
esv2760467 CNV gain 21179565
esv2715876 CNV deletion 23290073
esv2670934 CNV deletion 23128226
esv2664544 CNV deletion 23128226
dgv908e212 CNV gain 25503493
dgv5548n54 CNV loss 21841781
dgv5547n54 CNV loss 21841781
dgv5546n54 CNV loss 21841781
dgv5545n54 CNV gain 21841781
dgv5544n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5540n54 CNV loss 21841781
dgv5538n54 CNV gain 21841781
dgv5535n54 CNV gain 21841781
dgv5534n54 CNV gain 21841781
dgv545e199 CNV deletion 23128226
dgv523n67 CNV gain 20364138
dgv522n67 CNV gain 20364138
dgv3147n100 CNV gain 25217958
dgv3146n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv3143n100 CNV gain 25217958
dgv178n21 CNV loss 19592680
dgv121e55 CNV gain 17911159
dgv120e55 CNV gain 17911159

Variation tolerance for CCL4L2 Gene

Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL4L2

Disorders for CCL4L2 Gene

Relevant External Links for CCL4L2

Genetic Association Database (GAD)
CCL4L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL4L2

No disorders were found for CCL4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL4L2 Gene

Publications for CCL4L2 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 22 64
  2. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 22 64
  3. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4 64
  4. Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R. … Palou E. (Genes Immun. 2009) 3 22 64
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64

Products for CCL4L2 Gene

Sources for CCL4L2 Gene

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