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Aliases for CCL4L2 Gene

Aliases for CCL4L2 Gene

  • C-C Motif Chemokine Ligand 4 Like 2 2
  • Chemokine (C-C Motif) Ligand 4-Like 2 2 3 5
  • Monocyte Adherence-Induced Protein 5-Alpha 3 4
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • MIP-1-Beta 3 4
  • CCL4L 3 4
  • Lymphocyte Activation Gene 1 Protein 4
  • Macrophage Inflammatory Protein-1b2 3
  • Small Inducible Cytokine A4-Like 3
  • Small-Inducible Cytokine A4-Like 4
  • CCL4L1 CCL4L2 4
  • AT744.2 3
  • SCYA4L1 4
  • SCYA4L2 4
  • SCYQ4L2 3
  • SCYA4L 3
  • LAG-1 4
  • LAG1 4

External Ids for CCL4L2 Gene

Previous GeneCards Identifiers for CCL4L2 Gene

  • GC17P031665
  • GC17P034639
  • GC17Pj00266

Summaries for CCL4L2 Gene

Entrez Gene Summary for CCL4L2 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L2 Gene

CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a Protein Coding gene. Among its related pathways are Chemokine Signaling and PEDF Induced Signaling. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot for CCL4L2 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Wiki entry for CCL4L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L2 Gene

Genomics for CCL4L2 Gene

Regulatory Elements for CCL4L2 Gene

Enhancers for CCL4L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL4L2 on UCSC Golden Path with GeneCards custom track

Promoters for CCL4L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCL4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL4L2 Gene

Chromosome:
17
Start:
36,210,924 bp from pter
End:
36,212,878 bp from pter
Size:
1,955 bases
Orientation:
Plus strand

Genomic View for CCL4L2 Gene

Genes around CCL4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4L2 Gene

Proteins for CCL4L2 Gene

  • Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHW4-CC4L_HUMAN
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Q8NHW4
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L2 Gene

    Size:
    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L2 Gene

neXtProt entry for CCL4L2 Gene

Proteomics data for CCL4L2 Gene at MOPED

Post-translational modifications for CCL4L2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCL4L2 Gene

Domains & Families for CCL4L2 Gene

Gene Families for CCL4L2 Gene

Protein Domains for CCL4L2 Gene

Suggested Antigen Peptide Sequences for CCL4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHW4

UniProtKB/Swiss-Prot:

CC4L_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4L2: view

Function for CCL4L2 Gene

Molecular function for CCL4L2 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Phenotypes for CCL4L2 Gene

GenomeRNAi human phenotypes for CCL4L2:
genes like me logo Genes that share phenotypes with CCL4L2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L2 Gene

Localization for CCL4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL4L2 Gene COMPARTMENTS Subcellular localization image for CCL4L2 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for CCL4L2 Gene

Pathways & Interactions for CCL4L2 Gene

genes like me logo Genes that share pathways with CCL4L2: view

Interacting Proteins for CCL4L2 Gene

Selected Interacting proteins: Q8NHW4-CC4L_HUMAN for CCL4L2 Gene via UniProtKB

Symbol External ID(s) Details
SLC30A2

Gene Ontology (GO) - Biological Process for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0030593 neutrophil chemotaxis IBA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0048247 lymphocyte chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for SIGNOR curated interactions for CCL4L2 Gene

Drugs & Compounds for CCL4L2 Gene

No Compound Related Data Available

Transcripts for CCL4L2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L2 Gene

No ASD Table

Relevant External Links for CCL4L2 Gene

GeneLoc Exon Structure for
CCL4L2
ECgene alternative splicing isoforms for
CCL4L2

Expression for CCL4L2 Gene

mRNA expression in normal human tissues for CCL4L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.6).

mRNA Expression by UniProt/SwissProt for CCL4L2 Gene

Q8NHW4-CC4L_HUMAN
Tissue specificity: Detected in B-cells.
genes like me logo Genes that share expression patterns with CCL4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL4L2 Gene

Orthologs for CCL4L2 Gene

Evolution for CCL4L2 Gene

ENSEMBL:
Gene Tree for CCL4L2 (if available)
TreeFam:
Gene Tree for CCL4L2 (if available)

No data available for Orthologs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

genes like me logo Genes that share paralogs with CCL4L2: view

Variants for CCL4L2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene

Q8NHW4-CC4L_HUMAN
The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.

Sequence variations from dbSNP and Humsavar for CCL4L2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2940985 -- 36,211,948(-) GGCCC(C/T)CTTTA intron-variant, utr-variant-3-prime
rs4796195 -- 36,212,480(+) TCTAC(A/G)GATTC intron-variant, utr-variant-3-prime
rs62078208 -- 36,209,541(+) CATGG(A/G)CATTC upstream-variant-2KB
rs62078209 -- 36,211,739(+) TCCCA(C/T)GGGCA intron-variant
rs141559159 -- 36,212,499(+) AAGAG(G/T)CAAGC nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCL4L2 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv514838 CNV Complex 21397061
nsv436845 CNV Insertion 17901297
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv514839 CNV Complex 21397061

Variation tolerance for CCL4L2 Gene

Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL4L2 Gene

HapMap Linkage Disequilibrium report
CCL4L2

Disorders for CCL4L2 Gene

Relevant External Links for CCL4L2

Genetic Association Database (GAD)
CCL4L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL4L2

No disorders were found for CCL4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL4L2 Gene

Publications for CCL4L2 Gene

  1. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4 67
  2. Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R. … Palou E. (Genes Immun. 2009) 3 23
  3. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 23
  4. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 23
  5. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. (PMID: 25449536) Suviolahti E. … Toyoda M. (Transpl. Immunol. 2015) 3

Products for CCL4L2 Gene

Sources for CCL4L2 Gene

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