Aliases for CCL4L2 Gene
Aliases for CCL4L2 Gene
- C-C Motif Chemokine Ligand 4 Like 2 2 3 5
- Monocyte Adherence-Induced Protein 5-Alpha 3 4
- Macrophage Inflammatory Protein 1-Beta 3 4
- Chemokine (C-C Motif) Ligand 4-Like 2 2 3
- MIP-1-Beta 3 4
- CCL4L 3 4
- Lymphocyte Activation Gene 1 Protein 4
- Macrophage Inflammatory Protein-1b2 3
- Small Inducible Cytokine A4-Like 3
- Small-Inducible Cytokine A4-Like 4
External Ids for CCL4L2 Gene
- HGNC: 24066
- Entrez Gene: 9560
- Ensembl: ENSG00000276070
- OMIM: 610757
- UniProtKB: Q8NHW4
Previous GeneCards Identifiers for CCL4L2 Gene
- GC17P031665
- GC17P034639
- GC17Pj00266
Summaries for CCL4L2 Gene
-
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for CCL4L2 Gene
CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and PAK Pathway. An important paralog of this gene is CCL4.
UniProtKB/Swiss-Prot for CCL4L2 Gene
-
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L2 Gene
Genomics for CCL4L2 Gene
Regulatory Elements for CCL4L2 Gene
Enhancers for CCL4L2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G036589 | 1.7 | FANTOM5 ENCODE dbSUPER | 5 | +385.6 | 385598 | 13.7 | HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 | ZNHIT3 MYO19 ENSG00000274756 CCL4L2 DHRS11 GC17P036616 MRM1 |
| GH17G036528 | 0.9 | ENCODE | 7.6 | +318.1 | 318090 | 0.9 | ARNT TCF12 ZNF766 ELK1 GATA2 FOS JUNB MBD2 SMARCA4 MYNN | CCL4L2 GC17M036531 PIR53886 |
| GH17G036154 | 0.5 | FANTOM5 | 7.4 | -56.5 | -56452 | 0.4 | ZNF316 TBX21 | CCL4 CCL3 CCL3L1 CCL3L3 CCL4L2 CCL5 CCL23 GGNBP2 ENSG00000282738 LOC100420851 |
| GH17G036210 | 0.7 | Ensembl | 0.7 | +1.0 | 1041 | 3.0 | ZFP64 ZBTB11 ZNF426 ZNF394 ZBTB8A ZNF623 ZNF781 ZBTB40 ZNF518A ZNF697 | ENSG00000270871 LINC02001 CCL4L2 ENSG00000278097 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCL4L2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCL4L2 gene promoter:
Regulatory Element Products
Genomic Location for CCL4L2 Gene
- Chromosome:
- 17
- Start:
- 36,210,924 bp from pter
- End:
- 36,212,878 bp from pter
- Size:
- 1,955 bases
- Orientation:
- Plus strand
Genomic View for CCL4L2 Gene
Genes around CCL4L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
CCL4L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL4L2 Gene
Proteins for CCL4L2 Gene
-
Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NHW4-CC4L_HUMAN
- Recommended name:
- C-C motif chemokine 4-like
- Protein Accession:
- Q8NHW4
- B2RUZ3
- B7ZMA8
- Q50EM1
- Q50EM2
- Q50EM3
- Q50EM4
- Q50EM5
- Q50EM6
- Q50EM7
- Q50EM8
- Q569J2
- Q6NSB0
Protein attributes for CCL4L2 Gene
- Size:
- 92 amino acids
- Molecular mass:
- 10166 Da
- Quaternary structure:
-
- Interacts with CCR5.
- Interacts with CCR5.
Post-translational modifications for CCL4L2 Gene
No Post-translational modifications
Other Protein References for CCL4L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCL4L2
-
Cloud-Clone Corp. Antibodies for CCL4L2
- antibodies-online Antibodies for CCL4L2: See all 215
- Search GeneTex for Antibodies for CCL4L2
Protein Products
- R&D Systems Proteins and Enzymes for CCL4L2 (CCL4L1/LAG-1)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCL4L2
- Origene Custom Protein Services for CCL4L2
-
Cloud-Clone Corp. Proteins for CCL4L2
- antibodies-online Proteins for CCL4L2: See all 95
- Search antibodies-online for peptides
- GeneTex Proteins for CCL4L2
No data available for DME Specific Peptides for CCL4L2 Gene
Domains & Families for CCL4L2 Gene
Gene Families for CCL4L2 Gene
- HGNC:
Protein Domains for CCL4L2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL4L2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NHW4- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL4L2 Gene
Molecular function for CCL4L2 Gene
- UniProtKB/Swiss-Prot Function:
- Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0008009 | chemokine activity | IBA | -- |
| GO:0048020 | CCR chemokine receptor binding | IBA | -- |
Phenotypes for CCL4L2 Gene
- GenomeRNAi human phenotypes for CCL4L2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL4L2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL4L2 gene
- Search ViGene Biosciences for CCL4L2
CRISPR Products
- Browse CRISPR knockouts for CCL4L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL4L2
miRNA Products
- Search ViGene Biosciences for CCL4L2
Inhibitory RNA Products
- Origene siRNA and shRNA products in human, mouse, rat for CCL4L2
- Browse OriGene Inhibitory RNA Products For CCL4L2
- Search ViGene Biosciences for CCL4L2
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCL4L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCL4L2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL4L2 gene
- Search ViGene Biosciences for CCL4L2
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L2 Gene
Localization for CCL4L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for CCL4L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | ERK Signaling |
.61
|
|
| 3 | CCR5 Pathway in Macrophages | ||
| 4 | Akt Signaling |
.60
|
.60
|
| 5 | PAK Pathway |
.56
|
|
Pathways by source for CCL4L2 Gene
6 KEGG pathways for CCL4L2 Gene
17 Qiagen pathways for CCL4L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006935 | chemotaxis | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IBA | -- |
| GO:0030593 | neutrophil chemotaxis | IBA | -- |
No data available for SIGNOR curated interactions for CCL4L2 Gene
Transcripts for CCL4L2 Gene
mRNA/cDNA for CCL4L2 Gene
- (9) REFSEQ mRNAs :
- (105) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CCL4L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL4L2
miRNA Products
- Search ViGene Biosciences for CCL4L2
Inhibitory RNA Products
- Origene siRNA and shRNA products in human, mouse, rat for CCL4L2
- Browse OriGene Inhibitory RNA Products For CCL4L2
- Search ViGene Biosciences for CCL4L2
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCL4L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCL4L2 Gene
mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene
This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.6).
NURSA nuclear receptor signaling pathways regulating expression of CCL4L2 Gene:
CCL4L2mRNA Expression by UniProt/SwissProt for CCL4L2 Gene:
Q8NHW4-CC4L_HUMAN
Tissue specificity:
Detected in B-cells.
Evidence on tissue expression from TISSUES for CCL4L2 Gene
- Blood(4.9)
- Nervous system(4.2)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL4L2 Gene
Orthologs for CCL4L2 Gene
No data available for Orthologs for CCL4L2 Gene
Paralogs for CCL4L2 Gene
Paralogs for CCL4L2 Gene
(28) SIMAP similar genes for CCL4L2 Gene using alignment to 2 proteins:
Variants for CCL4L2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene
- CC4L_HUMAN-Q8NHW4
- The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002141415 | -- | 36,209,179(+) | GGTTG(C/T)AGGTA | upstream-variant-2KB | |
| rs1014227854 | -- | 36,209,992(+) | AATTC(-/TGTTT)TTATA | upstream-variant-2KB | |
| rs1024303240 | -- | 36,213,214(+) | TGTGG(C/G)GGGAG | downstream-variant-500B | |
| rs1027808767 | -- | 36,211,740(+) | CCCAT(-/GG)GCAGT | intron-variant | |
| rs1043549665 | -- | 36,209,119(+) | TATTG(A/G)CTGGG | upstream-variant-2KB |
Gene Damage Index Score:
0.51;
11.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCL4L2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCL4L2
Disorders for CCL4L2 Gene
Relevant External Links for CCL4L2
No disorders were found for CCL4L2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL4L2 Gene
Publications for CCL4L2 Gene
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 22 64
- Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 22 64
- CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4 64
- Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R. … Palou E. (Genes Immun. 2009) 3 22 64
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
Products for CCL4L2 Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for CCL4L2 (CCL4L1/LAG-1)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCL4L2
- Origene Custom Protein Services for CCL4L2
- Origene shRNA and siRNA products in human, mouse, rat for CCL4L2
- Browse OriGene Inhibitory RNA Products For CCL4L2
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for CCL4L2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL4L2
- GenScript: Next-day shipping cDNA ORF clone for CCL4L2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCL4L2
- GenScript Custom Assay Services for CCL4L2
- GenScript Custom overexpressing Cell Line Services for CCL4L2
- Browse GenScript CRISPR for CCL4L2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL4L2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCL4L2
- Novus Biologicals proteins and lysates for CCL4L2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CCL4L2
- Cloud-Clone Corp. Proteins for CCL4L2
- Browse Assay Kits at Cloud-Clone Corp.
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for CCL4L2: See all 215
- antibodies-online Kits for CCL4L2: See all 87
- antibodies-online Proteins for CCL4L2: See all 95
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CCL4L2
- GeneTex Proteins for CCL4L2
- ViGene Biosciences adenoviral particle packaged cDNA for CCL4L2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCL4L2 gene
- Search ViGene Biosciences for CCL4L2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL4L2
- VectorBuilder custom plasmid, inducible vectors for CCL4L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCL4L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (24) DrugBank
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- (28) RNAdb
- (29) ASD
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
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- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (44) GeneTests
- (45) HGMD
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- (48) BGMUT
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- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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