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Aliases for CCL4L1 Gene

Aliases for CCL4L1 Gene

  • Chemokine (C-C Motif) Ligand 4-Like 1 2
  • CCL4L 3 4 6
  • Monocyte Adherence-Induced Protein 5-Alpha 3 4
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Small Inducible Cytokine A4-Like 2 3
  • MIP-1-Beta 3 4
  • SCYA4L 3 6
  • LAG1 4 6
  • Chemokine (C-C Motif) Ligand 4-Like 2 3
  • Lymphocyte Activation Gene 1 Protein 4
  • Chemokine (C-C Motif) Ligand 4-Like 2
  • Macrophage Inflammatory Protein-1b2 3
  • Small-Inducible Cytokine A4-Like 4
  • C-C Motif Chemokine 4-Like 3
  • CCL4L1 CCL4L2 4
  • AT744.2 3
  • SCYQ4L2 3
  • SCYA4L1 4
  • SCYA4L2 4
  • CCL4L2 3
  • LAG-1 4

External Ids for CCL4L1 Gene

Previous Symbols for CCL4L1 Gene

  • SCYA4L
  • CCL4L

Summaries for CCL4L1 Gene

Entrez Gene Summary for CCL4L1 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L1 Gene

CCL4L1 (Chemokine (C-C Motif) Ligand 4-Like 1) is a Protein Coding gene. Diseases associated with CCL4L1 include hiv-1. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL4L1 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Wiki entry for CCL4L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L1 Gene

Genomics for CCL4L1 Gene

Genomic Location for CCL4L1 Gene

Start:
36,210,924 bp from pter
End:
36,212,878 bp from pter
Size:
1,955 bases
Orientation:
Plus strand

Genomic View for CCL4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4L1 Gene

Regulatory Elements for CCL4L1 Gene

Proteins for CCL4L1 Gene

  • Protein details for CCL4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHW4-CC4L_HUMAN
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Q8NHW4
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L1 Gene

    Size:
    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L1 Gene

neXtProt entry for CCL4L1 Gene

Proteomics data for CCL4L1 Gene at MOPED

Post-translational modifications for CCL4L1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCL4L1 Gene

Domains for CCL4L1 Gene

Gene Families for CCL4L1 Gene

HGNC:
  • CCL :Chemokine ligands

Protein Domains for CCL4L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHW4

UniProtKB/Swiss-Prot:

CC4L_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • Q8NHW4
genes like me logo Genes that share domains with CCL4L1: view

No data available for Suggested Antigen Peptide Sequences for CCL4L1 Gene

Function for CCL4L1 Gene

Molecular function for CCL4L1 Gene

UniProtKB/Swiss-Prot Function: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Ontology (GO) - Molecular Function for CCL4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity --
genes like me logo Genes that share ontologies with CCL4L1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL4L1 Gene

Localization for CCL4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL4L1 Gene COMPARTMENTS Subcellular localization image for CCL4L1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space --
genes like me logo Genes that share ontologies with CCL4L1: view

Pathways for CCL4L1 Gene

genes like me logo Genes that share pathways with CCL4L1: view

Interacting Proteins for CCL4L1 Gene

Selected Interacting proteins: Q8NHW4-CC4L_HUMAN for CCL4L1 Gene via UniProtKB

Symbol External ID(s) Details
SLC30A2

Gene Ontology (GO) - Biological Process for CCL4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response --
GO:0006955 immune response --
GO:0060326 cell chemotaxis --
genes like me logo Genes that share ontologies with CCL4L1: view

Transcripts for CCL4L1 Gene

Unigene Clusters for CCL4L1 Gene

Chemokine (C-C motif) ligand 4-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L1 Gene

No ASD Table

Relevant External Links for CCL4L1 Gene

GeneLoc Exon Structure for
CCL4L1
ECgene alternative splicing isoforms for
CCL4L1

Expression for CCL4L1 Gene

mRNA expression in normal human tissues for CCL4L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL4L1 Gene

This gene is overexpressed in Whole Blood (15.6) and Spleen (4.2).

SOURCE GeneReport for Unigene cluster for CCL4L1 Gene Hs.515183

mRNA Expression by UniProt/SwissProt for CCL4L1 Gene

Q8NHW4-CC4L_HUMAN
Tissue specificity: Detected in B-cells.
genes like me logo Genes that share expressions with CCL4L1: view

No data available for Protein expression for CCL4L1 Gene

Orthologs for CCL4L1 Gene

Evolution for CCL4L1 Gene

ENSEMBL:
Gene Tree for CCL4L1 (if available)
TreeFam:
Gene Tree for CCL4L1 (if available)

No data available for Orthologs for CCL4L1 Gene

Paralogs for CCL4L1 Gene

genes like me logo Genes that share paralogs with CCL4L1: view

No data available for Paralogs for CCL4L1 Gene

Variants for CCL4L1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L1 Gene

Q8NHW4-CC4L_HUMAN
The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome

Sequence variations from dbSNP and Humsavar for CCL4L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2940985 -- 36,211,948(-) GGCCC(C/T)CTTTA intron-variant, utr-variant-3-prime
rs62078208 -- 36,209,541(+) CATGG(A/G)CATTC upstream-variant-2KB
rs62078209 -- 36,211,739(+) TCCCA(C/T)GGGCA intron-variant
rs141559159 -- 36,212,499(+) AAGAG(G/T)CAAGC reference, missense, utr-variant-3-prime, nc-transcript-variant
rs142100639 -- 36,210,667(+) TTGTT(C/T)TTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL4L1 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv514838 CNV Complex 21397061
nsv436845 CNV Insertion 17901297
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv514839 CNV Complex 21397061

Relevant External Links for CCL4L1 Gene

HapMap Linkage Disequilibrium report
CCL4L1
Human Gene Mutation Database (HGMD)
CCL4L1

Disorders for CCL4L1 Gene

(1) MalaCards Diseases for CCL4L1 Gene

Search for CCL4L1 Gene in MalaCards »

Relevant External Links for CCL4L1

Genetic Association Database (GAD)
CCL4L1
Human Genome Epidemiology (HuGE) Navigator
CCL4L1
genes like me logo Genes that share disorders with CCL4L1: view

No data available for UniProtKB/Swiss-Prot for CCL4L1 Gene

Publications for CCL4L1 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 23 48
  2. Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R. … Palou E. (Genes Immun. 2009) 3 23 48
  3. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 23
  4. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CCL4L1 Gene

Sources for CCL4L1 Gene

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