Aliases for CCL4L1 Gene
Aliases for CCL4L1 Gene
- C-C Motif Chemokine Ligand 4 Like 1 2 3
- Monocyte Adherence-Induced Protein 5-Alpha 3 4
- Macrophage Inflammatory Protein 1-Beta 3 4
- Lymphocyte Activation Gene 1 Protein 3 4
- Small Inducible Cytokine A4-Like 2 3
- Small-Inducible Cytokine A4-Like 3 4
- MIP-1-Beta 3 4
- SCYA4L1 3 4
- SCYA4L2 3 4
- LAG-1 3 4
- CCL4L 3 4
Previous HGNC Symbols for CCL4L1 Gene
- SCYA4L
- CCL4L
Previous GeneCards Identifiers for CCL4L1 Gene
- GC17P034785
- GC17P031664
- GC17P031564
- GC17P034538
- GC17P030726
- GC17P036210
Summaries for CCL4L1 Gene
-
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for CCL4L1 Gene
CCL4L1 (C-C Motif Chemokine Ligand 4 Like 1) is a Protein Coding gene. Diseases associated with CCL4L1 include Omsk Hemorrhagic Fever and Japanese Spotted Fever. Among its related pathways are PEDF Induced Signaling and PAK Pathway. GO annotations related to this gene include chemokine activity.
UniProtKB/Swiss-Prot for CCL4L1 Gene
-
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L1 Gene
Genomics for CCL4L1 Gene
Regulatory Elements for CCL4L1 Gene
- Transcription factor binding sites by QIAGEN in the CCL4L1 gene promoter:
Regulatory Element Products
Genomic Location for CCL4L1 Gene
- Chromosome:
- 17
- Start:
- 266,611 bp from pter
- End:
- 268,581 bp from pter
- Size:
- 1,971 bases
- Orientation:
- Plus strand
Genomic View for CCL4L1 Gene
Genes around CCL4L1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 alternate reference locus by HGNC
Gene Density RefSeq DNA sequence for CCL4L1 Gene
Proteins for CCL4L1 Gene
-
Protein details for CCL4L1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NHW4-CC4L_HUMAN
- Recommended name:
- C-C motif chemokine 4-like
- Protein Accession:
- Q8NHW4
- B2RUZ3
- B7ZMA8
- Q50EM1
- Q50EM2
- Q50EM3
- Q50EM4
- Q50EM5
- Q50EM6
- Q50EM7
- Q50EM8
- Q569J2
- Q6NSB0
Protein attributes for CCL4L1 Gene
- Size:
- 92 amino acids
- Molecular mass:
- 10166 Da
- Quaternary structure:
-
- Interacts with CCR5.
- Interacts with CCR5.
Post-translational modifications for CCL4L1 Gene
No Post-translational modifications
Other Protein References for CCL4L1 Gene
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCL4L1
-
Abcam antibodies for CCL4L1
-
Cloud-Clone Corp. Antibodies for CCL4L1
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Protein Products
-
OriGene Purified Proteins for CCL4L1
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-
Cloud-Clone Corp. Proteins for CCL4L1
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-
Abcam proteins for CCL4L1
Assay Products
No data available for DME Specific Peptides for CCL4L1 Gene
Domains & Families for CCL4L1 Gene
Gene Families for CCL4L1 Gene
- HGNC:
Protein Domains for CCL4L1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
Q8NHW4- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
No data available for Suggested Antigen Peptide Sequences for CCL4L1 Gene
Function for CCL4L1 Gene
Molecular function for CCL4L1 Gene
- UniProtKB/Swiss-Prot Function:
- Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008009 | chemokine activity | IBA | -- |
| GO:0048020 | CCR chemokine receptor binding | IBA | -- |
Phenotypes for CCL4L1 Gene
- GenomeRNAi human phenotypes for CCL4L1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL4L1 gene
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CRISPR Products
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL4L1
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miRNA Products
- Search ViGene Biosciences for CCL4L1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCL4L1
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Clone Products
- Sino Biological Human cDNA Clone for CCL4L1
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCL4L1
-
ViGene Biosciences adenoviral particle packaged cDNA for CCL4L1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL4L1 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L1 Gene
Localization for CCL4L1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL4L1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IBA | -- |
Pathways & Interactions for CCL4L1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | ERK Signaling |
.61
|
|
| 3 | CCR5 Pathway in Macrophages | ||
| 4 | Akt Signaling |
.60
|
.60
|
| 5 | PAK Pathway |
.56
|
|
Pathways by source for CCL4L1 Gene
1 BioSystems pathway for CCL4L1 Gene
6 KEGG pathways for CCL4L1 Gene
17 Qiagen pathways for CCL4L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002548 | monocyte chemotaxis | IBA | -- |
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IBA | -- |
| GO:0030593 | neutrophil chemotaxis | IBA | -- |
| GO:0043547 | positive regulation of GTPase activity | IBA | -- |
No data available for SIGNOR curated interactions for CCL4L1 Gene
Transcripts for CCL4L1 Gene
mRNA/cDNA for CCL4L1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL4L1
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CCL4L1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCL4L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCL4L1 Gene
mRNA differential expression in normal tissues according to GTEx for CCL4L1 Gene
This gene is overexpressed in Whole Blood (x15.6) and Spleen (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of CCL4L1 Gene:
CCL4L1mRNA Expression by UniProt/SwissProt for CCL4L1 Gene:
Q8NHW4-CC4L_HUMAN
Tissue specificity:
Detected in B-cells.
Evidence on tissue expression from TISSUES for CCL4L1 Gene
- Blood(4.8)
- Nervous system(4.4)
- Lymph node(2.7)
- Bone marrow(2.6)
- Spleen(2.5)
- Lung(2.3)
- Liver(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCL4L1
-
OriGene qPCR primer pairs for CCL4L1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL4L1 Gene
Orthologs for CCL4L1 Gene
No data available for Orthologs and Evolution for CCL4L1 Gene
Paralogs for CCL4L1 Gene
(28) SIMAP similar genes for CCL4L1 Gene using alignment to 3 proteins:
No data available for Paralogs for CCL4L1 Gene
Variants for CCL4L1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L1 Gene
- CC4L_HUMAN-Q8NHW4
- The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs36074765 | -- | 36,213,156(+) | TGCTT(-/G)GGGAG | downstream-variant-500B |
Gene Damage Index Score:
5.98;
74.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCL4L1 Gene
Disorders for CCL4L1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| omsk hemorrhagic fever |
|
|
| japanese spotted fever |
|
|
| chronic nk-cell lymphocytosis |
|
|
| human immunodeficiency virus infectious disease |
|
|
Search CCL4L1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCL4L1
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL4L1 Gene
Publications for CCL4L1 Gene
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 46 64
- CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 2 3 4 64
- Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children. (PMID: 19279442) Shostakovich-Koretskaya L. … Ahuja S.K. (AIDS 2009) 22 46 64
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
- Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 64
Products for CCL4L1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL4L1
- VectorBuilder custom plasmid, inducible vectors for CCL4L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL4L1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCL4L1 Gene
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