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Aliases for CCL4 Gene

Subcategory (RNA class) for CCL4 Gene

lncRNA

Aliases for CCL4 Gene

  • Chemokine (C-C Motif) Ligand 4 2 3
  • SCYA4 3 4 6
  • MIP1B 3 4 6
  • Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b) 2 3
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Lymphocyte Activation Gene 1 Protein 3 4
  • G-26 T-Lymphocyte-Secreted Protein 3 4
  • T-Cell Activation Protein 2 3 4
  • MIP-1-Beta(1-69) 3 4
  • MIP-1-Beta 3 4
  • SIS-Gamma 3 4
  • PAT 744 3 4
  • AT744.1 3 6
  • LAG-1 3 4
  • LAG1 3 4
  • ACT2 3 6
  • HC21 3 4
  • Small-Inducible Cytokine A4 4
  • C-C Motif Chemokine 4 3
  • Secreted Protein G-26 3
  • Protein H400 4
  • MIP1B1 3
  • SCYA2 3
  • ACT-2 4
  • G-26 3

External Ids for CCL4 Gene

ORGUL Members for CCL4 Gene

Previous HGNC Symbols for CCL4 Gene

  • LAG1
  • SCYA4

Previous GeneCards Identifiers for CCL4 Gene

  • GC17P034201
  • GC17P036466
  • GC17P034279
  • GC17P034576
  • GC17P031421
  • GC17P034431
  • GC17P030617

Summaries for CCL4 Gene

Entrez Gene Summary for CCL4 Gene

  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

GeneCards Summary for CCL4 Gene

CCL4 (Chemokine (C-C Motif) Ligand 4) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL4 include stachybotrys chartarum and retinal vasculitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include identical protein binding and chemokine activity.

UniProtKB/Swiss-Prot for CCL4 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Gene Wiki entry for CCL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4 Gene

Genomics for CCL4 Gene

Regulatory Elements for CCL4 Gene

Genomic Location for CCL4 Gene

Start:
36,103,590 bp from pter
End:
36,105,621 bp from pter
Size:
2,032 bases
Orientation:
Plus strand

Genomic View for CCL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4 Gene

Proteins for CCL4 Gene

  • Protein details for CCL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13236-CCL4_HUMAN
    Recommended name:
    C-C motif chemokine 4
    Protein Accession:
    P13236
    Secondary Accessions:
    • P22617
    • Q13704
    • Q3SXL8
    • Q6FGI8

    Protein attributes for CCL4 Gene

    Size:
    92 amino acids
    Molecular mass:
    10212 Da
    Quaternary structure:
    • Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL4 Gene

neXtProt entry for CCL4 Gene

Proteomics data for CCL4 Gene at MOPED

Post-translational modifications for CCL4 Gene

  • N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes

Other Protein References for CCL4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL4 (CCL4/MIP-1 beta)

Protein Products

No data available for DME Specific Peptides for CCL4 Gene

Domains for CCL4 Gene

Gene Families for CCL4 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL4 Gene

Suggested Antigen Peptide Sequences for CCL4 Gene

Graphical View of Domain Structure for InterPro Entry

P13236

UniProtKB/Swiss-Prot:

CCL4_HUMAN :
  • P13236
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4: view

Function for CCL4 Gene

Molecular function for CCL4 Gene

UniProtKB/Swiss-Prot Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
UniProtKB/Swiss-Prot Induction: By mitogens

Gene Ontology (GO) - Molecular Function for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2462251
GO:0005515 protein binding IPI 23597562
GO:0008009 chemokine activity IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
GO:0031730 CCR5 chemokine receptor binding IPI 10679098
genes like me logo Genes that share ontologies with CCL4: view

Animal Model Products

CRISPR Products

miRNA for CCL4 Gene

miRTarBase miRNAs that target CCL4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL4 Gene

Localization for CCL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL4 Gene COMPARTMENTS Subcellular localization image for CCL4 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
cytosol 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL4: view

Pathways for CCL4 Gene

genes like me logo Genes that share pathways with CCL4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
    • Antiviral Response in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat

Interacting Proteins for CCL4 Gene

Gene Ontology (GO) - Biological Process for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9759849
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 10929056
GO:0007163 establishment or maintenance of cell polarity TAS 9759849
genes like me logo Genes that share ontologies with CCL4: view

Compounds for CCL4 Gene

(67) Novoseek inferred chemical compound relationships for CCL4 Gene

Compound -log(P) Hits PubMed IDs
rantes 97 260
ccl3 90.8 95
ccl4 84.6 147
mip 1alpha 84.3 20
groalpha 78.1 15
genes like me logo Genes that share compounds with CCL4: view

Transcripts for CCL4 Gene

mRNA/cDNA for CCL4 Gene

Unigene Clusters for CCL4 Gene

Chemokine (C-C motif) ligand 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4 Gene

No ASD Table

Relevant External Links for CCL4 Gene

GeneLoc Exon Structure for
CCL4
ECgene alternative splicing isoforms for
CCL4

Expression for CCL4 Gene

mRNA expression in normal human tissues for CCL4 Gene

mRNA differential expression in normal tissues according to GTEx for CCL4 Gene

This gene is overexpressed in Whole Blood (19.1) and Spleen (4.0).

SOURCE GeneReport for Unigene cluster for CCL4 Gene Hs.75703

genes like me logo Genes that share expressions with CCL4: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CCL4 Gene

Orthologs for CCL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL4 35
  • 98.19 (n)
  • 96.74 (a)
cow
(Bos Taurus)
Mammalia CCL4 35
  • 88.04 (n)
  • 86.96 (a)
dog
(Canis familiaris)
Mammalia CCL4 35
  • 88.04 (n)
  • 86.96 (a)
mouse
(Mus musculus)
Mammalia Ccl4 35
  • 81.88 (n)
  • 76.09 (a)
Ccl4 16
rat
(Rattus norvegicus)
Mammalia Ccl4 35
  • 82.97 (n)
  • 77.17 (a)
chicken
(Gallus gallus)
Aves CCL4 35
  • 59.93 (n)
  • 50.56 (a)
Species with no ortholog for CCL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL4 Gene

ENSEMBL:
Gene Tree for CCL4 (if available)
TreeFam:
Gene Tree for CCL4 (if available)

Paralogs for CCL4 Gene

genes like me logo Genes that share paralogs with CCL4: view

No data available for Paralogs for CCL4 Gene

Variants for CCL4 Gene

Sequence variations from dbSNP and Humsavar for CCL4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_048702 -
VAR_048703 -
VAR_059211 -

Structural Variations from Database of Genomic Variants (DGV) for CCL4 Gene

Variant ID Type Subtype PubMed ID
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv120e55 CNV Gain 17911159
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv457733 CNV Gain 19166990
nsv9540 CNV Gain+Loss 18304495
essv19054 CNV CNV 17122850
esv29264 CNV Gain+Loss 19812545
nsv908082 CNV Gain 21882294
dgv3143n71 CNV Gain 21882294
dgv3144n71 CNV Gain 21882294
esv2670934 CNV Deletion 23128226
dgv522n67 CNV Gain 20364138
esv2664544 CNV Deletion 23128226
dgv178n21 CNV Loss 19592680
dgv3145n71 CNV Gain 21882294
nsv514836 CNV Gain 21397061
dgv121e55 CNV Gain 17911159
dgv949e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
dgv523n67 CNV Gain 20364138
dgv3146n71 CNV Gain 21882294
nsv471396 CNV Duplication 19718026
nsv517262 CNV Gain+Loss 19592680
esv33107 CNV Loss 17666407

Relevant External Links for CCL4 Gene

HapMap Linkage Disequilibrium report
CCL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4 Gene

Disorders for CCL4 Gene

(1) University of Copenhagen DISEASES for CCL4 Gene

(74) Novoseek inferred disease relationships for CCL4 Gene

Disease -log(P) Hits PubMed IDs
necrosis 67.3 104
immunodeficiency 66.9 30
inflammation 63.1 14
hiv infections 61.4 15
virus infection 43.2 8

Relevant External Links for CCL4

Genetic Association Database (GAD)
CCL4
Human Genome Epidemiology (HuGE) Navigator
CCL4
genes like me logo Genes that share disorders with CCL4: view

No data available for UniProtKB/Swiss-Prot for CCL4 Gene

Publications for CCL4 Gene

  1. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PMID: 9521068) Bernardini G. … Napolitano M. (Eur. J. Immunol. 1998) 3 4 23
  2. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi C.G. … Umland S.P. (Eur. J. Immunol. 1999) 3 4 23
  3. Macrophage inflammatory protein-1. (PMID: 12401480) Menten P. … Van Damme J. (Cytokine Growth Factor Rev. 2002) 3 4 23
  4. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 23 48
  5. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 23

Products for CCL4 Gene

  • Addgene plasmids for CCL4

Sources for CCL4 Gene

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