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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL4 Gene

protein-coding GIFtS: 64
GCID: GC17P034431

chemokine (C-C motif) ligand 4

(Previous name: small inducible cytokine A4 (homologous to mouse Mip-1b)...)
(Previous symbols: LAG1, SCYA4)

Explore 140 diseases affiliated with
CCL4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 4¹ ²		G-26 T-Lymphocyte-Secreted Protein² ³
SCYA4¹ ² ³ ⁵		PAT 744² ³
LAG1¹ ² ³		T-Cell Activation Protein 2² ³
MIP-1-Beta¹		ACT2² ⁵
AT744.1¹ ² ⁵		Act-2¹
MIP1B² ³ ⁵		G-26²
Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b)¹ ²		MIP1B1²
Lymphocyte Activation Gene 1 Protein² ³		SCYA2²
Macrophage Inflammatory Protein 1-Beta² ³		C-C Motif Chemokine 4²
HC21² ³		Secreted Protein G-26²
LAG-1² ³		ACT-2³
MIP-1-Beta(1-69)¹		Protein H400³
SIS-Gamma¹		Small-Inducible Cytokine A4³

External Ids:	HGNC: 10630¹	Entrez Gene: 6351²	Ensembl: ENSG00000129277⁷	OMIM: 182284⁵	UniProtKB: P13236³

Export aliases for CCL4 gene to outside databases

Previous GC identifers: GC17P034201 GC17P036466 GC17P034279 GC17P034576 GC17P031421 GC17P030617

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL4:

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors

produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. (provided

by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: CCL4_HUMAN, P13236

Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive

factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of

HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to

induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of

HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B

Gene Wiki entry for CCL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL4 gene promoter:
CREB AML1a deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL4 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21-q23

CCL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P034431: view genomic region (about GC identifiers)

Start:	34,430,983 bp from pter	End:	34,433,014 bp from pter
Size:	2,032 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL4_HUMAN, P13236 (See protein sequence)

Recommended Name: C-C motif chemokine 4 precursor

Size: 92 amino acids; 10212 Da

Subunit: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69)

Subcellular location: Secreted

Caution: Was originally (PubMed:9521068) thought to be a ligand for CCR8

6/7 PDB 3D structures from and Proteopedia for CCL4 (see all 7):

1HUM (3D)

1HUN (3D)

1JE4 (3D)

2FFK (3D)

2FIN (3D)

2X6L (3D)

Secondary accessions: P22617 Q13704 Q3SXL8 Q6FGI8

Explore the universe of human proteins at neXtProt for CCL4: NX_P13236

Post-translational modifications:

N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood

lymphocytes¹

View neXtProt modification sites for NX_P13236

CCL4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002975.1

ENSEMBL proteins:

ENSP00000250151 ENSP00000378004

Reactome Protein details: P13236
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL4 (CCL4/MIP-1 beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CCL4 OriGene Protein Over-expression Lysate: CCL4 OriGene Custom Protein Services for CCL4
	GenScript Purified and Recombinant Proteins for CCL4
	Novus Biologicals CCL4 Proteins Novus Biologicals CCL4 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL4
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL4 for ontologies About GeneDecksing

CCL4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL4
	R&D Systems Antibodies for CCL4 (CCL4/MIP-1 beta)
	OriGene Antibodies (see all 2): CCL4 OriGene Custom Antibody Services for CCL4
	GenScript Custom Superior Antibodies Services for CCL4
	Novus Biologicals CCL4 Antibodies
	Abcam antibodies for CCL4
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for CCL4

Assay Products for CCL4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for CCL4 (CCL4/MIP-1 beta) (see first)
	R&D Systems ELISAs for CCL4 (CCL4/MIP-1 beta)
	R&D Systems Multiplex/Array Assay Kits & Reagents for CCL4 (CCL4/MIP-1 beta)
	See all other biochemical assays at R&D Systems
	GenScript Custom Assay Services for CCL4
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL4 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P13236

ProtoNet protein and cluster: P13236

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL4_HUMAN, P13236

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL4_HUMAN, P13236

Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive

factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of

HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to

induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of

HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B

Induction: By mitogens

miRNA Products:		miRTarBase miRNAs that target CCL4: hsa-mir-195 (MIRT004669)

		OriGene 3'-UTR Clone: CCL4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL4
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL4:
		hsa-miR-125a-3p hsa-miR-3919 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: CCL4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL4 (see all 7) OriGene shRNA RFP: CCL4 OriGene siRNA: CCL4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL4 (NM_002984)
		Sino Biological Human cDNA Clone for CCL4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL4
		Search LifeMap BioReagents cell lines for CCL4

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	2462251
GO:0008009	chemokine activity	IEA	--
GO:0031726	CCR1 chemokine receptor binding	IPI	7545673
GO:0031730	CCR5 chemokine receptor binding	IPI	10679098

CCL4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCL4

Apoptosis and survival APRIL and BAFF signaling

1 R&D Systems Pathway for CCL4

IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL4 (see all 28)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 GeneGo (Thomson Reuters) Pathway for CCL4

Apoptosis and survival APRIL and BAFF signaling

2 BioSystems Pathways for CCL4

	Toll-like receptor signaling pathway
	IL12-mediated signaling events

5/6 Reactome Pathways for CCL4 (see all 6)

	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding

4 Kegg Pathways (Kegg details for CCL4):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Toll-like receptor signaling pathway
	Cytosolic DNA-sensing pathway

CCL4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for CCL4 (P13236^{2, 3} ENSP00000250151⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IDE	P14735²^,³, ENSP00000265986⁴	MINT-8087616 I2D: score=1 STRING: ENSP00000265986
CCR1	P32246³, ENSP00000296140⁴	I2D: score=5 STRING: ENSP00000296140
CCBP2	O00590³, ENSP00000273145⁴	I2D: score=4 STRING: ENSP00000273145
CCL3	P10147³, ENSP00000225245⁴	I2D: score=3 STRING: ENSP00000225245
CCR5	P51681³, ENSP00000292303⁴	I2D: score=3 STRING: ENSP00000292303

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	9759849
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007155	cell adhesion	TAS	10929056

CCL4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL4
10/67 Novoseek chemical compound relationships for CCL4 gene (see all 67) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	97	722	10888363 (7), 11861332 (6), 9746565 (6), 16924394 (5) (see all 99)
ccl3	90.8	130	12960284 (3), 15585374 (3), 16773571 (3), 19074730 (3) (see all 74)
ccl4	84.6	232	14761932 (7), 15240137 (6), 15843566 (4), 14673550 (4) (see all 99)
mip 1alpha	84.3	23	16518599 (5), 18403790 (4), 11097208 (2), 9343222 (1) (see all 12)
groalpha	78.1	15	10437780 (2), 16542377 (2), 10419917 (1), 17228323 (1) (see all 13)
tarc	76.6	17	10540332 (3), 9521068 (2), 15941911 (1), 9153236 (1) (see all 12)
grogamma	71	3	10467937 (2), 11808935 (1)
larc	68.8	9	18492658 (3), 9153236 (1), 9169480 (1), 10449163 (1) (see all 7)
mcp 1	59.6	5	10559777 (2), 15660413 (1), 17993576 (1), 11683586 (1)
mdms	58.3	7	16857988 (1), 9870313 (1), 10082122 (1), 11839143 (1)

Search CenterWatch for drugs/clinical trials and news about CCL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL4 gene:

NM_002984.2

Unigene Cluster for CCL4:

Chemokine (C-C motif) ligand 4

Hs.75703 [show with all ESTs]

Unigene Representative Sequence: CD521853

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000250151(uc002hkw.1) ENST00000394495(uc002hkx.1) ENST00000591883

miRNA Products:		OriGene 3'-UTR Clone: CCL4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL4
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL4:
		hsa-miR-125a-3p hsa-miR-3919 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: CCL4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL4 (see all 7) OriGene shRNA RFP: CCL4 OriGene siRNA: CCL4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL4 (NM_002984)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL4

Additional cDNA sequence:

AY312578.1 AY766446.1 AY766448.1 BC104226.1 BC104227.1 BC107433.1 CR542119.1 J04130.1

M23502.1 M25316.1 M57503.1 X16166.1 X53683.1

11 DOTS entries:

DT.100044914 DT.100044255 DT.97766642 DT.100890234 DT.86854556 DT.100890235 DT.100762795 DT.120948312

DT.95267994 DT.95267995 DT.120948253

24/177 AceView cDNA sequences (see all 177):

AI359523 AA362359 AA362350 AI862912 CR610625 T29074 AA362287 BE326709

AI341064 AI343539 CD522113 BE670804 CA309238 BV203909 AI632318 BM543715

CD641246 CD523031 CA435072 CD639587 CD522220 BX438752 AY312578 AW006861

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATAACACAT

About this image

CCL4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

See CCL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL4

SOURCE GeneReport for Unigene cluster: Hs.75703

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL4 (see all 14):

HIV Host Response in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Antiviral Response in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

T-cell & B-cell Activation in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL4

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL4 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	zgc:193706⁶ si:dkeyp-59a8.3⁶ (see all 6)	si:dkeyp-59a8.3 (see all 6)	34(a) 32(a) (see all 6)	many ↔ many many ↔ many (see all 6)	25(25902180-25904281) 20(38310380-38311158)

ENSEMBL Gene Tree for CCL4 (if available)
TreeFam Gene Tree for CCL4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL4 gene

CCL15² CCL16² CCL2² CCL14² CCL24² CCL4L1² CCL11² CCL4L2²

CCL7² CCL3L1² CCL5² CCL23² CCL3L3² CCL8² CCL13² CCL26²

CCL3² CCL18²

18/28 SIMAP similar genes for CCL4 using alignment to 3 protein entries: CCL4_HUMAN (see all proteins) (see all similar genes):

CCL4L2 LOC728835 CCL4L1 CCL3L1 CCL3 CCL14

CCL5 CCL3L3 CCL11 CCL18 CCL7 MCP-3

CCL2 CCL16 CCL26 CCL8 CCL13 CCL22

CCL4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4993527^1,2	C	--	34429665(+)	`GCACAC/TTCCTG`	1	--	us2k¹		0	--	--	--	--
rs62079736^1,2		--	34429752(+)	`CATGGA/GCATTC`	1	--	us2k¹		0	--	--	--	--
rs59797189^1,2	C,F,	--	34429834(+)	`ACTAGA/GTATAT`	1	--	us2k¹		8		WA NA CSA EA	366
rs2011522^1,2		--	34429906(+)	`caagcG/Tggagt`	1	--	us2k¹		0	--	--	--	--
rs139606400^1,2		--	34430040(+)	`TTTATA/GGAGAC`	1	--	us2k¹		0	--	--	--	--
rs143457996^1,2		--	34430125(+)	`GTGCTA/GGGATT`	1	--	us2k¹		0	--	--	--	--
rs188726623^1,2		--	34430190(+)	`TCTCTA/GTCTGG`	1	--	us2k¹		0	--	--	--	--
rs181035291^1,2		--	34430214(+)	`GATTCC/TTACTG`	1	--	us2k¹		0	--	--	--	--
rs185143631^1,2		--	34430228(+)	`AATTTG/TTCCTG`	1	--	us2k¹		0	--	--	--	--
rs189608513^1,2		--	34430233(+)	`GTCCTA/GTTCTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL4 (34430983 - 34433014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 23 variations for CCL4
15/23 CNVs (see all 23): 7154 88442 88435 8841 8840 30824 88441 88440 77579 8842 34507 3142 77575 72873 34571

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL4 for disorders           About GeneDecksing

OMIM gene information: 182284    OMIM disorders: --

20/140 diseases for CCL4 (see all 140):    About MalaCards

erdheim-chester disease periapical granuloma stachybotrys chartarum diffuse large b-cell lymphoma

human immunodeficiency virus infectious disease meconium aspiration syndrome hemolytic-uremic syndrome pulmonary alveolar proteinosis

mycobacterial infection relapsing polychondritis b-cell lymphomas temporal lobe epilepsy

plasmodium falciparum malaria toxic shock syndrome pre-eclampsia hemophagocytic lymphohistiocytosis

proliferative diabetic retinopathy alopecia areata wegener's granulomatosis proliferative vitreoretinopathy

2 diseases from the University of Copenhagen DISEASES database for CCL4:

Human immunodeficiency virus infectious disease Liver disease

10/74 Novoseek disease relationships for CCL4 gene (see all 74) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	67.3	152	14726627 (2), 14586377 (2), 18622277 (2), 10496934 (2) (see all 99)
immunodeficiency	66.9	34	10979927 (2), 9343222 (1), 9359702 (1), 12427015 (1) (see all 29)
inflammation	63.1	15	9841832 (2), 11097208 (1), 12548712 (1), 14761932 (1) (see all 13)
hiv infections	61.4	17	9732062 (2), 9649315 (1), 10461827 (1), 11120614 (1) (see all 14)
virus infection	43.2	8	10501489 (1), 19155475 (1), 17547763 (1), 19846870 (1) (see all 8)
tumors	43.2	132	15126779 (5), 14586377 (2), 18622277 (2), 12473593 (2) (see all 99)
periapical granuloma	39.6	2	11683586 (2)
aids	37.6	17	9466518 (3), 9420304 (2), 10618285 (1), 16773571 (1) (see all 10)
fibrosis idiopathic pulmonary	32.6	5	11031344 (1), 10384061 (1), 19046553 (1)
viremia	27.5	1	18234797 (1)

Genetic Association Database (GAD): CCL4
Human Genome Epidemiology (HuGE) Navigator: CCL4 (17 documents)

Export disorders for CCL4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL4 gene, integrated from 9 sources (see all 946):
(articles sorted by number of sources associating them with CCL4)

Utopia: connect your pdf to the dynamic
world of online information

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PubMed id 15843566)^{1, 2, 9} Colobran R.... Juan M. (2005)
Macrophage inflammatory protein-1. (PubMed id 12401480)^{1, 2, 9} Menten P.... Van Damme J. (2002)
Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)^{1, 2, 9} Bernardini G....Napolitano M. (1998)
The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)^{1, 2, 9} Garlisi C.G....Umland S.P. (1999)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Natural truncation of the chemokine MIP-1beta/CCL4 affects receptor specificity but not anti-HIV-1 activity. (PubMed id 12070155)^{1, 2} Guan E.... Norcross M.A. (2002)
No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans. (PubMed id 11129109)^{1, 4} Kim K.W....Woo J.I. (2000)
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. (PubMed id 8525373)^{1, 2} Cocchi F....Lusso P. (1995)
High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. (PubMed id 8134838)^{1, 2} Lodi P.J.... Clore G.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6351	HGNC: 10630	AceView: CCL4	Ensembl:ENSG00000129277	euGenes: HUgn6351
ECgene: CCL4	Kegg: 6351	H-InvDB: CCL4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCL4	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein

Intellectual Property for CCL4 gene
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Patent Information for CCL4 gene:
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GeneCards and IP:
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CCL4 Gene

chemokine (C-C motif) ligand 4

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CCL4 (Gene Symbol)
Chemokine (C-C Motif) Ligand 4
SCYA4
LAG1
MIP-1-Beta
AT744.1
MIP1B
Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b)
Lymphocyte Activation Gene 1 Protein
Macrophage Inflammatory Protein 1-Beta
HC21
LAG-1
MIP-1-Beta(1-69)
SIS-Gamma
G-26 T-Lymphocyte-Secreted Protein
PAT 744
T-Cell Activation Protein 2
ACT2
Act-2
G-26
MIP1B1
SCYA2
C-C Motif Chemokine 4
Secreted Protein G-26
ACT-2
Protein H400
Small-Inducible Cytokine A4

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Edema
Toxic Shock Syndrome
Asthma
AIDS
Cancer
Uveitis
Lymphoma
Lyme Disease
Meningitis
Bronchoalveolar Lavage Fluid
Osteolysis
Multiple Sclerosis
BONE LESION
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Malaria Falciparum
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STROKE
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CCL4 Gene

chemokine (C-C motif) ligand 4

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