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CCL4 Gene(Protein Coding)

C-C Motif Chemokine Ligand 4

GCID:
GC17P036103
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CCL4 Gene

Aliases for CCL4 Gene

  • C-C Motif Chemokine Ligand 4 2 3
  • Chemokine (C-C Motif) Ligand 4 2 3 5
  • Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b) 2 3
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Lymphocyte Activation Gene 1 Protein 3 4
  • G-26 T-Lymphocyte-Secreted Protein 3 4
  • T-Cell Activation Protein 2 3 4
  • MIP-1-Beta(1-69) 3 4
  • MIP-1-Beta 3 4
  • SIS-Gamma 3 4
  • PAT 744 3 4
  • SCYA4 3 4
  • LAG-1 3 4
  • MIP1B 3 4
  • LAG1 3 4
  • HC21 3 4
  • Small-Inducible Cytokine A4 4
  • Secreted Protein G-26 3
  • Protein H400 4
  • AT744.1 3
  • MIP1B1 3
  • SCYA2 3
  • ACT-2 4
  • ACT2 3
  • G-26 3

External Ids for CCL4 Gene

Previous HGNC Symbols for CCL4 Gene

  • LAG1
  • SCYA4

Previous GeneCards Identifiers for CCL4 Gene

  • GC17P034201
  • GC17P036466
  • GC17P034279
  • GC17P034576
  • GC17P031421
  • GC17P034431
  • GC17P030617

Summaries for CCL4 Gene

Entrez Gene Summary for CCL4 Gene

  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

GeneCards Summary for CCL4 Gene

CCL4 (C-C Motif Chemokine Ligand 4) is a Protein Coding gene. Diseases associated with CCL4 include Omsk Hemorrhagic Fever and Meningitis. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include identical protein binding and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot for CCL4 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Gene Wiki entry for CCL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4 Gene

Genomics for CCL4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCL4 Gene

Enhancers for CCL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL4 on UCSC Golden Path with GeneCards custom track

Promoters for CCL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCL4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CCL4 gene promoter:

Genomic Location for CCL4 Gene

Chromosome:
17
Start:
36,103,590 bp from pter
End:
36,105,621 bp from pter
Size:
2,032 bases
Orientation:
Plus strand

Genomic View for CCL4 Gene

Genes around CCL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL4 Gene

Proteins for CCL4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13236-CCL4_HUMAN
    Recommended name:
    C-C motif chemokine 4
    Protein Accession:
    P13236
    Secondary Accessions:
    • P22617
    • Q13704
    • Q3SXL8
    • Q6FGI8

    Protein attributes for CCL4 Gene

    Size:
    92 amino acids
    Molecular mass:
    10212 Da
    Quaternary structure:
    • Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL4 Gene

neXtProt entry for CCL4 Gene

Proteomics data for CCL4 Gene at MOPED

Post-translational modifications for CCL4 Gene

  • N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Other Protein References for CCL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL4 (CCL4/MIP-1 beta)

No data available for DME Specific Peptides for CCL4 Gene

Domains & Families for CCL4 Gene

Gene Families for CCL4 Gene

HGNC:

Protein Domains for CCL4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13236

UniProtKB/Swiss-Prot:

CCL4_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4: view

Function for CCL4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CCL4 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Gene Ontology (GO) - Molecular Function for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2462251
genes like me logo Genes that share ontologies with CCL4: view

Phenotypes for CCL4 Gene

GenomeRNAi human phenotypes for CCL4:
genes like me logo Genes that share phenotypes with CCL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL4

miRNA for CCL4 Gene

miRTarBase miRNAs that target CCL4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL4 Gene

Localization for CCL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL4 Gene COMPARTMENTS Subcellular localization image for CCL4 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CCL4 Gene

Pathways & Interactions for CCL4 Gene

genes like me logo Genes that share pathways with CCL4: view

Interacting Proteins for CCL4 Gene

Selected Interacting proteins: P13236-CCL4_HUMAN for CCL4 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006928 movement of cell or subcellular component TAS 9759849
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA,TAS 10929056
GO:0007155 cell adhesion TAS 10929056
genes like me logo Genes that share ontologies with CCL4: view

No data available for SIGNOR curated interactions for CCL4 Gene

Drugs & Compounds for CCL4 Gene

Products:

  1. Drug

(32) Drugs for CCL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(35) Additional Compounds for CCL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL4: view

Transcripts for CCL4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCL4 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(177) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL4 Gene

Chemokine (C-C motif) ligand 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4 Gene

No ASD Table

Relevant External Links for CCL4 Gene

GeneLoc Exon Structure for
CCL4
ECgene alternative splicing isoforms for
CCL4

Expression for CCL4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CCL4 Gene

mRNA expression in normal human tissues for CCL4 Gene
mRNA expression by BioGPS for CCL4 GenemRNA expression by GTEx for CCL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL4 Gene

This gene is overexpressed in Whole Blood (x19.1) and Spleen (x4.0).

SOURCE GeneReport for Unigene cluster for CCL4 Gene Hs.75703

genes like me logo Genes that share expression patterns with CCL4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCL4 Gene

Orthologs for CCL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CCL4 35
  • 88.04 (n)
  • 86.96 (a)
dog
(Canis familiaris)
 Mammalia CCL4 35
  • 88.04 (n)
  • 86.96 (a)
mouse
(Mus musculus)
 Mammalia Ccl4 35
  • 81.88 (n)
  • 76.09 (a)
Ccl4 16
chimpanzee
(Pan troglodytes)
 Mammalia CCL4 35
  • 98.19 (n)
  • 96.74 (a)
rat
(Rattus norvegicus)
 Mammalia Ccl4 35
  • 82.97 (n)
  • 77.17 (a)
chicken
(Gallus gallus)
 Aves CCL4 35
  • 59.93 (n)
  • 50.56 (a)
Species with no ortholog for CCL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL4 Gene

ENSEMBL:
Gene Tree for CCL4 (if available)
TreeFam:
Gene Tree for CCL4 (if available)

Paralogs for CCL4 Gene

Paralogs for CCL4 Gene

(28) SIMAP similar genes for CCL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL4: view

Variants for CCL4 Gene

Sequence variations from dbSNP and Humsavar for CCL4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_048702 -
rs1130750 - 36,103,964(+) CTCTC(C/T)AGCAC reference, missense
rs1719152 - 36,105,271(+) GTGAA(A/T)CCTGG reference, missense
rs940001 -- 36,102,557(+) acttt(C/T)ctggg upstream-variant-2KB
rs1634513 -- 36,102,441(+) ACTAG(A/G)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL4 Gene

Variant ID Type Subtype PubMed ID
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv120e55 CNV Gain 17911159
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv457733 CNV Gain 19166990
nsv9540 CNV Gain+Loss 18304495
essv19054 CNV CNV 17122850
esv29264 CNV Gain+Loss 19812545
nsv908082 CNV Gain 21882294
dgv3143n71 CNV Gain 21882294
dgv3144n71 CNV Gain 21882294
esv2670934 CNV Deletion 23128226
dgv522n67 CNV Gain 20364138
esv2664544 CNV Deletion 23128226
dgv178n21 CNV Loss 19592680
dgv3145n71 CNV Gain 21882294
nsv514836 CNV Gain 21397061
dgv121e55 CNV Gain 17911159
dgv949e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
dgv523n67 CNV Gain 20364138
dgv3146n71 CNV Gain 21882294
nsv471396 CNV Duplication 19718026
nsv517262 CNV Gain+Loss 19592680
esv33107 CNV Loss 17666407

Variation tolerance for CCL4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCL4 Gene

Disorders for CCL4 Gene

MalaCards: The human disease database

(15) MalaCards diseases for CCL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
omsk hemorrhagic fever
  • hemorrhagic fever, omsk
meningitis
demyelinating disease
  • demyelinating disorder
viral infectious disease
  • arbovirus infectious disease
acute cervicitis
- elite association - COSMIC cancer census association via MalaCards
Search CCL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL4

Genetic Association Database (GAD)
CCL4
Human Genome Epidemiology (HuGE) Navigator
CCL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL4
genes like me logo Genes that share disorders with CCL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL4 Gene

Publications for CCL4 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 23 48 67
  2. Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages. (PMID: 18802359) Ichiyama T. … Furukawa S. (Int. Arch. Allergy Immunol. 2009) 3 23
  3. Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production. (PMID: 19057841) Abe M. … Matsumoto T. (J. Bone Miner. Metab. 2009) 3 23
  4. High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. (PMID: 19074730) Burger J.A. … Rosenwald A. (Blood 2009) 3 23
  5. Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species. (PMID: 19328808) Tatara Y. … Rakugi H. (J. Mol. Cell. Cardiol. 2009) 3 23

Products for CCL4 Gene

  • Addgene plasmids for CCL4

Sources for CCL4 Gene

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