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Aliases for CCL4 Gene

Aliases for CCL4 Gene

  • C-C Motif Chemokine Ligand 4 2 3 5
  • Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b) 2 3
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Lymphocyte Activation Gene 1 Protein 3 4
  • G-26 T-Lymphocyte-Secreted Protein 3 4
  • Chemokine (C-C Motif) Ligand 4 2 3
  • T-Cell Activation Protein 2 3 4
  • MIP-1-Beta(1-69) 3 4
  • MIP-1-Beta 3 4
  • SIS-Gamma 3 4
  • PAT 744 3 4
  • SCYA4 3 4
  • LAG-1 3 4
  • MIP1B 3 4
  • LAG1 3 4
  • HC21 3 4
  • Small-Inducible Cytokine A4 4
  • C-C Motif Chemokine 4 3
  • Secreted Protein G-26 3
  • Protein H400 4
  • AT744.1 3
  • MIP1B1 3
  • SCYA2 3
  • ACT-2 4
  • ACT2 3
  • G-26 3

External Ids for CCL4 Gene

Previous HGNC Symbols for CCL4 Gene

  • LAG1
  • SCYA4

Previous GeneCards Identifiers for CCL4 Gene

  • GC17P034201
  • GC17P036466
  • GC17P034279
  • GC17P034576
  • GC17P031421
  • GC17P034431
  • GC17P030617

Summaries for CCL4 Gene

Entrez Gene Summary for CCL4 Gene

  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

GeneCards Summary for CCL4 Gene

CCL4 (C-C Motif Chemokine Ligand 4) is a Protein Coding gene. Diseases associated with CCL4 include Hiv-1 and Meningitis. Among its related pathways are Immune System and Toll-like receptor signaling pathway. GO annotations related to this gene include identical protein binding and chemokine activity. An important paralog of this gene is CCL4L2.

UniProtKB/Swiss-Prot for CCL4 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Gene Wiki entry for CCL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4 Gene

Genomics for CCL4 Gene

Regulatory Elements for CCL4 Gene

Enhancers for CCL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036149 1.5 FANTOM5 Ensembl ENCODE 62.8 +45.9 45857 1.1 PKNOX1 TBL1XR1 ZNF76 ZNF2 RAD21 ZBTB40 YY1 RFX5 ZNF366 ZNF143 CCL4 CCL3 CCL3L3 CCL5 CCL23 GGNBP2 LOC101927369 ENSG00000282738 LOC100420851
GH17F036086 1.6 FANTOM5 Ensembl ENCODE 40.7 -13.5 -13546 6.3 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 NSD2 YBX1 BMI1 RAD21 ZNF335 CCL3 CCL4 CCL3L3 CCL18 TAF5LP1 SLFN12L CCL5 GGNBP2 ENSG00000277089
GH17F036102 1.5 FANTOM5 Ensembl ENCODE 41.3 +2.1 2053 6.9 PKNOX1 ATF1 KLF17 BMI1 SCRT2 CREM EGR2 CEBPB TBX21 ZNF518A CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 ENSG00000270871 PIGW SLFN12L MYO19
GH17F035888 1.4 FANTOM5 Ensembl ENCODE 20.3 -212.3 -212342 5.5 PKNOX1 SIN3A PTRF BMI1 ETV6 ZNF263 ZNF362 CEBPB JUNB ELF1 CCL3 CCL4 CCL3L3 TAF15 GAS2L2 C17orf50 HEATR9 CCL5 SLFN12L LYZL6
GH17F036055 0.5 FANTOM5 43.6 -47.4 -47377 0.5 IRF1 CCL3L3 CCL4 CCL3 CCL5 CCL23 LOC105371746 GC17M036029
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL4 Gene

Chromosome:
17
Start:
36,103,590 bp from pter
End:
36,105,621 bp from pter
Size:
2,032 bases
Orientation:
Plus strand

Genomic View for CCL4 Gene

Genes around CCL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4 Gene

Proteins for CCL4 Gene

  • Protein details for CCL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13236-CCL4_HUMAN
    Recommended name:
    C-C motif chemokine 4
    Protein Accession:
    P13236
    Secondary Accessions:
    • P22617
    • Q13704
    • Q3SXL8
    • Q6FGI8

    Protein attributes for CCL4 Gene

    Size:
    92 amino acids
    Molecular mass:
    10212 Da
    Quaternary structure:
    • Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL4 Gene

neXtProt entry for CCL4 Gene

Post-translational modifications for CCL4 Gene

  • N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Other Protein References for CCL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL4 (CCL4/MIP-1 beta)

No data available for DME Specific Peptides for CCL4 Gene

Domains & Families for CCL4 Gene

Gene Families for CCL4 Gene

Protein Domains for CCL4 Gene

Suggested Antigen Peptide Sequences for CCL4 Gene

Graphical View of Domain Structure for InterPro Entry

P13236

UniProtKB/Swiss-Prot:

CCL4_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4: view

Function for CCL4 Gene

Molecular function for CCL4 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Gene Ontology (GO) - Molecular Function for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,TAS 2462251
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
GO:0031730 CCR5 chemokine receptor binding IPI 10679098
genes like me logo Genes that share ontologies with CCL4: view
genes like me logo Genes that share phenotypes with CCL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL4

miRNA for CCL4 Gene

miRTarBase miRNAs that target CCL4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCL4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL4 Gene

Localization for CCL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL4 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL4: view

Pathways & Interactions for CCL4 Gene

genes like me logo Genes that share pathways with CCL4: view

Gene Ontology (GO) - Biological Process for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006928 movement of cell or subcellular component TAS 9759849
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA,TAS 10929056
genes like me logo Genes that share ontologies with CCL4: view

No data available for SIGNOR curated interactions for CCL4 Gene

Drugs & Compounds for CCL4 Gene

(35) Drugs for CCL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(32) Additional Compounds for CCL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL4: view

Transcripts for CCL4 Gene

mRNA/cDNA for CCL4 Gene

Unigene Clusters for CCL4 Gene

Chemokine (C-C motif) ligand 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4 Gene

No ASD Table

Relevant External Links for CCL4 Gene

GeneLoc Exon Structure for
CCL4
ECgene alternative splicing isoforms for
CCL4

Expression for CCL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL4 Gene

This gene is overexpressed in Whole Blood (x19.1) and Spleen (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CCL4 Gene:

CCL4

SOURCE GeneReport for Unigene cluster for CCL4 Gene:

Hs.75703
genes like me logo Genes that share expression patterns with CCL4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCL4 Gene

Orthologs for CCL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL4 34
  • 98.19 (n)
cow
(Bos Taurus)
Mammalia CCL4 34
  • 88.04 (n)
dog
(Canis familiaris)
Mammalia CCL4 34
  • 88.04 (n)
rat
(Rattus norvegicus)
Mammalia Ccl4 34
  • 82.97 (n)
mouse
(Mus musculus)
Mammalia Ccl4 34 16
  • 81.88 (n)
chicken
(Gallus gallus)
Aves CCL4 34
  • 59.93 (n)
Species where no ortholog for CCL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL4 Gene

ENSEMBL:
Gene Tree for CCL4 (if available)
TreeFam:
Gene Tree for CCL4 (if available)

Paralogs for CCL4 Gene

genes like me logo Genes that share paralogs with CCL4: view

Variants for CCL4 Gene

Sequence variations from dbSNP and Humsavar for CCL4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10491121 -- 36,102,943(+) AGTCC(A/G)AATAT intron-variant, upstream-variant-2KB
rs1049746 -- 36,103,818(-) ACTGA(C/G)TTGGG intron-variant, upstream-variant-2KB
rs1049750 -- 36,103,894(+) TCTTT(G/T)CCACC intron-variant, utr-variant-5-prime
rs1049752 -- 36,103,939(+) TCCTC(A/G)TGCTA intron-variant, reference, missense
rs1049804 -- 36,105,255(+) GTCTG(C/T)GCTGA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCL4 Gene

Variant ID Type Subtype PubMed ID
nsv960473 CNV duplication 23825009
nsv953882 CNV deletion 24416366
nsv820772 CNV deletion 20802225
nsv574788 CNV gain+loss 21841781
nsv574783 CNV gain 21841781
nsv574781 CNV gain 21841781
nsv574780 CNV gain+loss 21841781
nsv514838 CNV gain 21397061
nsv433448 CNV gain 18776910
nsv2040 CNV deletion 18451855
nsv1143852 CNV deletion 24896259
nsv1133405 CNV deletion 24896259
nsv1072731 CNV deletion 25765185
nsv1061448 CNV gain+loss 25217958
nsv1061066 CNV loss 25217958
esv3893005 CNV loss 25118596
esv3893001 CNV gain 25118596
esv3450833 CNV duplication 20981092
esv3345949 CNV duplication 20981092
esv33107 CNV loss 17666407
esv2762388 CNV gain+loss 21179565
esv2760467 CNV gain 21179565
dgv5548n54 CNV loss 21841781
dgv5547n54 CNV loss 21841781
dgv5546n54 CNV loss 21841781
dgv5545n54 CNV gain 21841781
dgv5544n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5540n54 CNV loss 21841781
dgv5538n54 CNV gain 21841781
dgv545e199 CNV deletion 23128226
dgv3147n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958

Variation tolerance for CCL4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4 Gene

Disorders for CCL4 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CCL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
meningitis
whiplash
demyelinating disease
  • demyelinating disorder
viral infectious disease
  • arthropod-borne viruses
- elite association - COSMIC cancer census association via MalaCards
Search CCL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL4

Genetic Association Database (GAD)
CCL4
Human Genome Epidemiology (HuGE) Navigator
CCL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL4
genes like me logo Genes that share disorders with CCL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL4 Gene

Publications for CCL4 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 22 46 64
  2. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R. … Juan M. (J. Immunol. 2005) 3 4 22 64
  3. Macrophage inflammatory protein-1. (PMID: 12401480) Menten P. … Van Damme J. (Cytokine Growth Factor Rev. 2002) 3 4 22 64
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi C.G. … Umland S.P. (Eur. J. Immunol. 1999) 3 4 22 64
  5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PMID: 9521068) Bernardini G. … Napolitano M. (Eur. J. Immunol. 1998) 3 4 22 64

Products for CCL4 Gene

  • Cloud-Clone Corp. Antibodies for CCL4
  • Cloud-Clone Corp. Proteins for CCL4
  • Cloud-Clone Corp Assay Kits for CCL4

Sources for CCL4 Gene

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