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Aliases for CCL3L3 Gene

Aliases for CCL3L3 Gene

  • Chemokine (C-C Motif) Ligand 3-Like 3 2 3
  • Tonsillar Lymphocyte LD78 Beta Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-2 3 4
  • LD78-Beta(1-70) 3 4
  • D17S1718 3 4
  • G0S19-2 3 4
  • SCYA3L1 3 4
  • Chemokine (C-C Motif) Ligand 3-Like, Centromeric 3
  • Small Inducible Cytokine A3-Like 1 3
  • Small-Inducible Cytokine A3-Like 1 4
  • C-C Motif Chemokine 3-Like 1 3
  • CCL3L1 CCL3L3 4
  • PAT 464.2 4
  • LD78BETA 3
  • SCYA3L 3
  • 464.2 3
  • LD78 3

External Ids for CCL3L3 Gene

Summaries for CCL3L3 Gene

Entrez Gene Summary for CCL3L3 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

GeneCards Summary for CCL3L3 Gene

CCL3L3 (Chemokine (C-C Motif) Ligand 3-Like 3) is a Protein Coding gene. Diseases associated with CCL3L3 include hiv-1. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL3L3 Gene

  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L3 Gene

Genomics for CCL3L3 Gene

Genomic Location for CCL3L3 Gene

Start:
36,194,869 bp from pter
End:
36,196,758 bp from pter
Size:
1,890 bases
Orientation:
Minus strand

Genomic View for CCL3L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL3L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL3L3 Gene

Regulatory Elements for CCL3L3 Gene

Proteins for CCL3L3 Gene

  • Protein details for CCL3L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16619-CL3L1_HUMAN
    Recommended name:
    C-C motif chemokine 3-like 1
    Protein Accession:
    P16619
    Secondary Accessions:
    • A6NGK6
    • B2RUX4
    • Q3B7A8
    • Q53YA5
    • Q96I68

    Protein attributes for CCL3L3 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL3L3 Gene

Proteomics data for CCL3L3 Gene at MOPED

Post-translational modifications for CCL3L3 Gene

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Other Protein References for CCL3L3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL3L3 Gene

Domains for CCL3L3 Gene

Gene Families for CCL3L3 Gene

HGNC:
  • CCL :Chemokine ligands

Protein Domains for CCL3L3 Gene

UniProtKB/Swiss-Prot:

CL3L1_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • P16619
genes like me logo Genes that share domains with CCL3L3: view

Function for CCL3L3 Gene

Molecular function for CCL3L3 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL3L3: view

miRNA for CCL3L3 Gene

miRTarBase miRNAs that target CCL3L3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL3L3 Gene

Localization for CCL3L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3L3 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL3L3: view

Pathways for CCL3L3 Gene

genes like me logo Genes that share pathways with CCL3L3: view

Interacting Proteins for CCL3L3 Gene

Selected Interacting proteins: P16619-CL3L1_HUMAN for CCL3L3 Gene via I2D

Gene Ontology (GO) - Biological Process for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 1694014
GO:0006955 immune response IEA --
GO:0008285 negative regulation of cell proliferation TAS 2271120
GO:0060326 cell chemotaxis IEA --
genes like me logo Genes that share ontologies with CCL3L3: view

Transcripts for CCL3L3 Gene

mRNA/cDNA for CCL3L3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL3L3 Gene

Chemokine (C-C motif) ligand 3-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3L3 Gene

No ASD Table

Relevant External Links for CCL3L3 Gene

GeneLoc Exon Structure for
CCL3L3
ECgene alternative splicing isoforms for
CCL3L3

Expression for CCL3L3 Gene

mRNA expression in normal human tissues for CCL3L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL3L3 Gene

This gene is overexpressed in Whole Blood (7.4).

SOURCE GeneReport for Unigene cluster for CCL3L3 Gene Hs.454713

genes like me logo Genes that share expressions with CCL3L3: view

Orthologs for CCL3L3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL3L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC749913 36
  • 94.27 (n)
  • 92.47 (a)
cow
(Bos Taurus)
Mammalia CCL3 36
  • 82.02 (n)
  • 71.05 (a)
dog
(Canis familiaris)
Mammalia CCL3 36
  • 79.71 (n)
  • 70.65 (a)
mouse
(Mus musculus)
Mammalia Ccl3 36
  • 78.99 (n)
  • 76.09 (a)
rat
(Rattus norvegicus)
Mammalia Ccl3 36
  • 79.71 (n)
  • 77.17 (a)
Species with no ortholog for CCL3L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL3L3 Gene

ENSEMBL:
Gene Tree for CCL3L3 (if available)
TreeFam:
Gene Tree for CCL3L3 (if available)

Paralogs for CCL3L3 Gene

genes like me logo Genes that share paralogs with CCL3L3: view

No data available for Paralogs for CCL3L3 Gene

Variants for CCL3L3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L3 Gene

P16619-CL3L1_HUMAN
The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies

Sequence variations from dbSNP and Humsavar for CCL3L3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1828283 -- 36,196,280(+) CTGTT(C/G)TTCAC intron-variant
rs2282674 -- 36,197,124(-) TGATC(C/T)GCAGC upstream-variant-2KB
rs57561051 -- 36,198,272(+) TTTGC(-/C)AAAAT upstream-variant-2KB
rs57582618 -- 36,197,367(+) AAAAA(-/A)GAATT upstream-variant-2KB
rs138676215 -- 36,195,587(+) CCTGT(C/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL3L3 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv514837 CNV Complex 21397061
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv436845 CNV Insertion 17901297
dgv951e1 CNV Complex 17122850
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv511598 CNV Loss 21212237
nsv514839 CNV Complex 21397061
nsv471397 CNV Duplication 19718026

Relevant External Links for CCL3L3 Gene

HapMap Linkage Disequilibrium report
CCL3L3

Disorders for CCL3L3 Gene

(1) MalaCards Diseases for CCL3L3 Gene

Search for CCL3L3 Gene in MalaCards »
genes like me logo Genes that share disorders with CCL3L3: view

No data available for UniProtKB/Swiss-Prot for CCL3L3 Gene

Publications for CCL3L3 Gene

  1. Structures of human genes coding for cytokine LD78 and their expression. (PMID: 1694014) Nakao M. … Shimada K. (Mol. Cell. Biol. 1990) 3 4
  2. Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. (PMID: 1972563) Irving S.G. … Kelly K. (Nucleic Acids Res. 1990) 3 4
  3. Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PMID: 2271120) Blum S. … Forsdyke D.R. (DNA Cell Biol. 1990) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi W.S. (Genomics 2004) 3

Products for CCL3L3 Gene

Sources for CCL3L3 Gene

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