Free for academic non-profit institutions. Other users need a Commercial license

CCL3L3 Gene(Protein Coding)

C-C Motif Chemokine Ligand 3 Like 3

GCID:
GC17M036194
GIFtS:
46
Genes Participants
UDN Logo

Aliases for CCL3L3 Gene

Aliases for CCL3L3 Gene

  • C-C Motif Chemokine Ligand 3 Like 3 2 3 5
  • Tonsillar Lymphocyte LD78 Beta Protein 3 4
  • Chemokine (C-C Motif) Ligand 3-Like 3 2 3
  • G0/G1 Switch Regulatory Protein 19-2 3 4
  • LD78-Beta(1-70) 3 4
  • D17S1718 3 4
  • SCYA3L1 3 4
  • G0S19-2 3 4
  • Chemokine (C-C Motif) Ligand 3-Like, Centromeric 3
  • Small Inducible Cytokine A3-Like 1 3
  • Small-Inducible Cytokine A3-Like 1 4
  • C-C Motif Chemokine 3-Like 1 3
  • CCL3L1 CCL3L3 4
  • PAT 464.2 4
  • LD78BETA 3
  • SCYA3L 3
  • 464.2 3
  • LD78 3

External Ids for CCL3L3 Gene

Previous GeneCards Identifiers for CCL3L3 Gene

  • GC17M031547
  • GC17M034523

Summaries for CCL3L3 Gene

Entrez Gene Summary for CCL3L3 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

GeneCards Summary for CCL3L3 Gene

CCL3L3 (C-C Motif Chemokine Ligand 3 Like 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Interleukin-10 signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.

UniProtKB/Swiss-Prot for CCL3L3 Gene

  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L3 Gene

Genomics for CCL3L3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCL3L3 Gene

Enhancers for CCL3L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G036149 1.6 FANTOM5 Ensembl ENCODE 52.3 +47.4 47393 0.9 PKNOX1 ZNF2 YY1 ZNF207 ZNF143 DEK ZNF263 YY2 REST GLIS1 CCL4 CCL3 CCL3L3 CCL3L1 CCL5 CCL23 GGNBP2 LOC101927369 ENSG00000282738 LOC100420851
GH17G036102 1.5 FANTOM5 Ensembl ENCODE 35.1 +90.8 90754 6.2 PKNOX1 ATF1 KLF17 BMI1 SCRT2 ZNF143 RELB IKZF2 CREM EGR2 CCL4 CCL3 CCL3L1 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L ENSG00000277089
GH17G036092 1.1 FANTOM5 ENCODE 38.2 +104.4 104406 0.5 MTA2 BHLHE40 MAFG BACH1 TBX21 RELA IKZF1 EED NFE2 ETV6 CCL3 CCL3L1 CCL3L3 CCL4 CCL18 CCL5 GGNBP2
GH17G035888 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +305.5 305510 5.5 PKNOX1 SIN3A BMI1 YY1 ZNF207 RELB ETV6 IKZF2 ZNF263 ZNF362 CCL3 CCL4 CCL3L1 CCL3L3 TAF15 GAS2L2 C17orf50 HEATR9 CCL5 SLFN12L
GH17G036055 0.5 FANTOM5 48.1 +140.5 140545 0.5 IRF1 CCL3L1 CCL3L3 CCL4 CCL3 CCL5 CCL23 LOC105371746 GC17M036054
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL3L3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CCL3L3 gene promoter:

Genomic Location for CCL3L3 Gene

Chromosome:
17
Start:
36,194,869 bp from pter
End:
36,196,758 bp from pter
Size:
1,890 bases
Orientation:
Minus strand

Genomic View for CCL3L3 Gene

Genes around CCL3L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL3L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL3L3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL3L3 Gene

Proteins for CCL3L3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL3L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16619-CL3L1_HUMAN
    Recommended name:
    C-C motif chemokine 3-like 1
    Protein Accession:
    P16619
    Secondary Accessions:
    • A6NGK6
    • B2RUX4
    • Q3B7A8
    • Q53YA5
    • Q96I68

    Protein attributes for CCL3L3 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL3L3 Gene

Post-translational modifications for CCL3L3 Gene

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Other Protein References for CCL3L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL3L3 Gene

Domains & Families for CCL3L3 Gene

Gene Families for CCL3L3 Gene

HGNC:

Protein Domains for CCL3L3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL3L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16619

UniProtKB/Swiss-Prot:

CL3L1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3L3: view

Function for CCL3L3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CCL3L3 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL3L3: view
genes like me logo Genes that share phenotypes with CCL3L3: view

Animal Models for CCL3L3 Gene

MGI Knock Outs for CCL3L3:

Animal Model Products

CRISPR Products

miRNA for CCL3L3 Gene

miRTarBase miRNAs that target CCL3L3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL3L3 Gene

Localization for CCL3L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3L3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL3L3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with CCL3L3: view

Pathways & Interactions for CCL3L3 Gene

genes like me logo Genes that share pathways with CCL3L3: view

Interacting Proteins for CCL3L3 Gene

Selected Interacting proteins: P16619-CL3L1_HUMAN for CCL3L3 Gene via IID

Gene Ontology (GO) - Biological Process for CCL3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response TAS 1694014
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CCL3L3: view

No data available for SIGNOR curated interactions for CCL3L3 Gene

Drugs & Compounds for CCL3L3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCL3L3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCL3L3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL3L3 Gene

Chemokine (C-C motif) ligand 3-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3L3 Gene

No ASD Table

Relevant External Links for CCL3L3 Gene

GeneLoc Exon Structure for
CCL3L3
ECgene alternative splicing isoforms for
CCL3L3

Expression for CCL3L3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL3L3 Gene

mRNA expression in normal human tissues for CCL3L3 Gene
mRNA expression by BioGPS for CCL3L3 GenemRNA expression by GTEx for CCL3L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL3L3 Gene

This gene is overexpressed in Whole Blood (x7.4).

NURSA nuclear receptor signaling pathways regulating expression of CCL3L3 Gene:

CCL3L3

SOURCE GeneReport for Unigene cluster for CCL3L3 Gene:

Hs.454713

Evidence on tissue expression from TISSUES for CCL3L3 Gene

  • Blood(4.3)
  • Pancreas(4)
  • Spleen(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CCL3L3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL3L3 Gene

Orthologs for CCL3L3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL3L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC749948 34
  • 94.27 (n)
cow
(Bos Taurus)
 Mammalia CCL3 34
  • 82.02 (n)
dog
(Canis familiaris)
 Mammalia CCL3 34
  • 79.71 (n)
rat
(Rattus norvegicus)
 Mammalia Ccl3 34
  • 79.71 (n)
mouse
(Mus musculus)
 Mammalia Ccl3 34 16
  • 78.99 (n)
Species where no ortholog for CCL3L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL3L3 Gene

ENSEMBL:
Gene Tree for CCL3L3 (if available)
TreeFam:
Gene Tree for CCL3L3 (if available)

Paralogs for CCL3L3 Gene

Paralogs for CCL3L3 Gene

(30) SIMAP similar genes for CCL3L3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL3L3: view

Variants for CCL3L3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L3 Gene

CL3L1_HUMAN-P16619
The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.

Sequence variations from dbSNP and Humsavar for CCL3L3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1010790555 -- 36,197,455(+) GGATA(C/G)GGTCA upstream-variant-2KB
rs1022174028 -- 36,197,770(+) GACCC(A/G)GCATC upstream-variant-2KB
rs113266921 -- 36,198,514(-) AACTA(A/G)ATCTA upstream-variant-2KB
rs143191190 -- 36,194,553(+) ACTCA(-/G)TAGGA downstream-variant-500B
rs1801628 -- 36,196,601(-) CTGCA(C/T)CACTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCL3L3 Gene

Variant ID Type Subtype PubMed ID
dgv3144n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3146n100 CNV gain 25217958
dgv3147n100 CNV gain 25217958
dgv545e199 CNV deletion 23128226
dgv5536n54 CNV gain 21841781
dgv5538n54 CNV gain 21841781
dgv5540n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5554n54 CNV loss 21841781
dgv5557n54 CNV loss 21841781
esv2715876 CNV deletion 23290073
esv2760467 CNV gain 21179565
esv2762388 CNV gain+loss 21179565
esv33107 CNV loss 17666407
esv3333423 CNV duplication 20981092
esv3374119 CNV duplication 20981092
esv3397133 CNV duplication 20981092
esv3438495 CNV duplication 20981092
esv3893001 CNV gain 25118596
esv3893005 CNV loss 25118596
nsv1061066 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1066186 CNV gain 25217958
nsv1072731 CNV deletion 25765185
nsv1133405 CNV deletion 24896259
nsv1143852 CNV deletion 24896259
nsv1160469 CNV duplication 26073780
nsv2040 CNV deletion 18451855
nsv433448 CNV gain 18776910
nsv471397 CNV gain 19718026
nsv514837 CNV gain 21397061
nsv574780 CNV gain+loss 21841781
nsv574781 CNV gain 21841781
nsv574783 CNV gain 21841781
nsv820772 CNV deletion 20802225
nsv953882 CNV deletion 24416366
nsv960473 CNV duplication 23825009

Relevant External Links for CCL3L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL3L3

No data available for Variation tolerance for CCL3L3 Gene

Disorders for CCL3L3 Gene

Relevant External Links for CCL3L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL3L3

No disorders were found for CCL3L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL3L3 Gene

Publications for CCL3L3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Structures of human genes coding for cytokine LD78 and their expression. (PMID: 1694014) Nakao M. … Shimada K. (Mol. Cell. Biol. 1990) 3 4 64
  3. Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. (PMID: 1972563) Irving S.G. … Kelly K. (Nucleic Acids Res. 1990) 3 4 64
  4. Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PMID: 2271120) Blum S. … Forsdyke D.R. (DNA Cell Biol. 1990) 3 4 64
  5. Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. (PMID: 26116899) Zahoor M.A. … Aida Y. (Virus Res. 2015) 3 64

Products for CCL3L3 Gene

Sources for CCL3L3 Gene

Content
Loading form....