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Aliases for CCL3L1 Gene

Aliases for CCL3L1 Gene

  • Chemokine (C-C Motif) Ligand 3-Like 1 2 3
  • Tonsillar Lymphocyte LD78 Beta Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-2 3 4
  • Small Inducible Cytokine A3-Like 1 2 3
  • LD78-Beta(1-70) 3 4
  • D17S1718 3 4
  • G0S19-2 3 4
  • SCYA3L1 3 4
  • Small-Inducible Cytokine A3-Like 1 4
  • CCL3L1 CCL3L3 4
  • PAT 464.2 4
  • LD78BETA 3
  • SCYA3L 3
  • MIP1AP 3
  • 464.2 3
  • LD78 3

External Ids for CCL3L1 Gene

Previous HGNC Symbols for CCL3L1 Gene

  • D17S1718
  • SCYA3L
  • SCYA3L1

Previous GeneCards Identifiers for CCL3L1 Gene

  • GC17U990089
  • GC17M036564
  • GC17M034769
  • GC17M031635
  • GC17M034522
  • GC17M034623

Summaries for CCL3L1 Gene

Entrez Gene Summary for CCL3L1 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL3L1 Gene

CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1) is a Protein Coding gene. Diseases associated with CCL3L1 include asymptomatic dengue and hiv-1. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL3L1 Gene

  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Wiki entry for CCL3L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L1 Gene

Genomics for CCL3L1 Gene

Regulatory Elements for CCL3L1 Gene

Genomic Location for CCL3L1 Gene

Chromosome:
17
Start:
250,577 bp from pter
End:
252,466 bp from pter
Size:
1,890 bases
Orientation:
Minus strand

Genomic View for CCL3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CCL3L1 Gene

Proteins for CCL3L1 Gene

  • Protein details for CCL3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16619-CL3L1_HUMAN
    Recommended name:
    C-C motif chemokine 3-like 1
    Protein Accession:
    P16619
    Secondary Accessions:
    • A6NGK6
    • B2RUX4
    • Q3B7A8
    • Q53YA5
    • Q96I68

    Protein attributes for CCL3L1 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL3L1 Gene

Proteomics data for CCL3L1 Gene at MOPED

Post-translational modifications for CCL3L1 Gene

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Other Protein References for CCL3L1 Gene

REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL3L1 Gene

Domains & Families for CCL3L1 Gene

Gene Families for CCL3L1 Gene

Protein Domains for CCL3L1 Gene

Graphical View of Domain Structure for InterPro Entry

P16619

UniProtKB/Swiss-Prot:

CL3L1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3L1: view

No data available for Suggested Antigen Peptide Sequences for CCL3L1 Gene

Function for CCL3L1 Gene

Molecular function for CCL3L1 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL3L1: view
genes like me logo Genes that share phenotypes with CCL3L1: view

miRNA for CCL3L1 Gene

miRTarBase miRNAs that target CCL3L1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL3L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3L1 Gene

Localization for CCL3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL3L1 Gene COMPARTMENTS Subcellular localization image for CCL3L1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL3L1: view

Pathways & Interactions for CCL3L1 Gene

genes like me logo Genes that share pathways with CCL3L1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T-cell & B-cell Activation in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat

Interacting Proteins for CCL3L1 Gene

Selected Interacting proteins: P16619-CL3L1_HUMAN for CCL3L1 Gene via I2D

Gene Ontology (GO) - Biological Process for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006954 inflammatory response TAS 1694014
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0008285 negative regulation of cell proliferation TAS 2271120
GO:0030593 neutrophil chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL3L1: view

No data available for SIGNOR curated interactions for CCL3L1 Gene

Drugs & Compounds for CCL3L1 Gene

(3) Drugs for CCL3L1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL3 Pharma Full agonist, Agonist 0
CCL4 Pharma Antagonist 0
Calcium Nutra 0

(1) Additional Compounds for CCL3L1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
RANTES
genes like me logo Genes that share compounds with CCL3L1: view

Transcripts for CCL3L1 Gene

Unigene Clusters for CCL3L1 Gene

Chemokine (C-C motif) ligand 3-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL3L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3L1 Gene

No ASD Table

Relevant External Links for CCL3L1 Gene

GeneLoc Exon Structure for
CCL3L1
ECgene alternative splicing isoforms for
CCL3L1

Expression for CCL3L1 Gene

mRNA expression in normal human tissues for CCL3L1 Gene

mRNA differential expression in normal tissues according to GTEx for CCL3L1 Gene

This gene is overexpressed in Whole Blood (x6.5).

SOURCE GeneReport for Unigene cluster for CCL3L1 Gene Hs.512683

genes like me logo Genes that share expression patterns with CCL3L1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCL3L1 Gene

Orthologs for CCL3L1 Gene

No data available for Orthologs and Evolution for CCL3L1 Gene

Paralogs for CCL3L1 Gene

genes like me logo Genes that share paralogs with CCL3L1: view

No data available for Paralogs for CCL3L1 Gene

Variants for CCL3L1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L1 Gene

P16619-CL3L1_HUMAN
The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies

Sequence variations from dbSNP and Humsavar for CCL3L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs112830445 -- 1(+) TCTGT(C/T)TATAT intron-variant
rs140666182 -- 1(+) TCTAA(A/C)GTGAA upstream-variant-2KB
rs141216390 -- 1(+) AAATA(G/T)ATTTA upstream-variant-2KB
rs142572769 -- 1(+) GTGAA(C/G)AACAG intron-variant
rs144464753 -- 1(+) CATTA(C/T)ACAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL3L1 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv514837 CNV Complex 21397061
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv436845 CNV Insertion 17901297
dgv951e1 CNV Complex 17122850
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv511598 CNV Loss 21212237
nsv514839 CNV Complex 21397061
nsv471397 CNV Duplication 19718026

Variation tolerance for CCL3L1 Gene

Gene Damage Index Score: 0.01; 0.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL3L1 Gene

HapMap Linkage Disequilibrium report
CCL3L1
Human Gene Mutation Database (HGMD)
CCL3L1

Disorders for CCL3L1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL3L1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
asymptomatic dengue
hiv-1
  • aids, slow progression to
papillon-lefevre syndrome
  • papillon-lefevre disease
- elite association

Relevant External Links for CCL3L1

Genetic Association Database (GAD)
CCL3L1
Human Genome Epidemiology (HuGE) Navigator
CCL3L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL3L1
genes like me logo Genes that share disorders with CCL3L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3L1 Gene

Publications for CCL3L1 Gene

  1. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. (PMID: 1296815) Hirashima M. … Shimada K. (DNA Seq. 1992) 2 23 67
  2. Variations in CCL3L gene cluster sequence and non-specific gene copy numbers. (PMID: 20233400) Shrestha S. … Edberg J.C. (BMC Res Notes 2010) 23 67
  3. HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5. (PMID: 19287150) Nakajima T. … Kimura A. (Cytogenet. Genome Res. 2008) 23 67
  4. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. (PMID: 17604289) McKinney C. … Merriman T.R. (Ann. Rheum. Dis. 2008) 23 67
  5. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 23 67

Products for CCL3L1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL3L1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL3L1
    • Block miRNA regulation of CCL3L1 using miScript Target Protectors

    Sources for CCL3L1 Gene

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