 |
 | Services
| |
 |
Aliases & Descriptions for CCL3L1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 464.2 2 | | D17S1718 2, 3 | | G0S19-2 1, 2, 3 | | LD78 2, 5 | | LD78-beta(1-70) 3 | | LD78BETA 1, 2 | | MGC104178 2 | | MGC12815 2 | | MGC182017 2 | | MIP1AP 2 | | SCYA3L 2 | | SCYA3L1 2, 3, 5 |
| | | Descriptions |
|---|
| G0/G1 switch regulatory protein 19-2 3 | | G0S19-2 protein 3 | | PAT 464.2 3 | | Small-inducible cytokine A3-like 1 3 | | Tonsillar lymphocyte LD78 beta protein 3 | | chemokine (C-C motif) ligand 3-like 1 2 | | small inducible cytokine A3-like 1 1, 2 |
|
| | Search outside databases for aliases for CCL3L1 genePrevious GC identifers: GC17U990089 GC17M036564 GC17M034769 |
Summaries for CCL3L1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CCL3L1: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene and a partial pseudogene. This record represents the more telomeric full-length gene. [provided by RefSeq] UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5Gene Wiki entry for CCL3L1 |
Genomic Location for CCL3L1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CCL3L1 gene 
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12CCL3L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M031635:
(about GC identifiers)
Start:
|
31,647,955 bp from pter |
End:
|
31,649,844 bp from pter |
Size:
|
1,890 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010799.14
| Proteins for CCL3L1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619 (See
protein sequence)Recommended Name: C-C motif chemokine 3-like 1 precursor Size: 93 amino acids; 10161 Da
Subcellular location: Secreted
Secondary accessions: A6NGK6 B2RUX4 Q3B7A8 Q53YA5 Q96I68Post-translational modifications:
The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP41
REFSEQ proteins: NP_066286.1
ENSEMBL proteins: ENSP00000377981 ENSP00000377982 ENSP00000367597
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for CCL3L1: Assays for CCL3L1: | Protein
Domains/ Families for CCL3L1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P16619
ProtoNet protein and cluster: P16619 1 Blocks protein family: IPB000827 Small chemokine
UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619Similarity: Belongs to the intercrine beta (chemokine CC) family | Gene Function for CCL3L1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021006
Applied Biosystems Silencer® siRNAs for CCL3L1
Sigma-Aldrich siRNA for CCL3L1  Sigma-Aldrich shRNA Panels and shRNA for CCL3L1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021006                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021006                                  untagged cDNA clones in CMV expression vector (see all 2): BC027888 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC027888
UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5 | Pathways & Interactions for CCL3L1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/41 Interacting proteins for CCL3L1 (ENSP000003675973) via UniProtKB, MINT, and/or STRING (see all 41
)About this table
|
Drugs & Compounds for CCL3L1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CCL3L1 4 Novoseek chemical compound relationships for CCL3L1 gene
About this table
|
Transcripts for CCL3L1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021006
Sigma-Aldrich siRNA for CCL3L1  Sigma-Aldrich shRNA Panels and shRNA for CCL3L1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021006 REFSEQ mRNAs for CCL3L1 gene: NM_021006.4               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021006                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021006                                  untagged cDNA clones in CMV expression vector (see all 2): BC027888  Additional cDNA sequence: BC027888.1 BC107710.1 BC146914.1 BC146919.1 BC147008.1 BC147013.1 X52149.1 6 DOTS entries: DT.100035793 DT.120948225 DT.449023 DT.97858828 DT.100759261 DT.95371117 24/42 AceView cDNA sequences (see all 42
):AA382113 BU626588 AA362364 AA362273 CA430410 NM_021006 R54639 AA366594 AA382070 AL543270 AA361985 AA380745 N47995 BM992482 CF128666 AA371389 X52149 BC027888 BI839085 AA362365 AA382112 AW959359 AW059858 AV647106
highest scoring ESTs for CCL3L1:AI348011 AV738689 AA366594 AL543270 AV739733 AW959359 BC027888 BF662985 BI839085 BU626588 Unigene Cluster for CCL3L1: Chemokine (C-C motif) ligand 3-like 1 Hs.512683 [show with all ESTs]Unigene Representative Sequence: BF662985
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000394469
ENST00000394470
ENST00000378346
|
Expression for CCL3L1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CCL3L1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CCL3L1
1 / 2 / 3 3 probe-sets matching CCL3L1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.512683
|
Orthologs for CCL3L1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CCL3L1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for CCL3L1
ENSEMBL Gene Tree for CCL3L1 | Paralogs for CCL3L1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CCL3L1 gene
- CCL3L31 2 LOC7288301 2 ENSG000002156272 CCL142 CCL4L12 CCL4L22 CCL32 CCL52
- CCL42 CCL182
|
SNPs/Variants for CCL3L1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619Polymorphism: The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies |
Disorders & Mutations for CCL3L1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601395 disorders: 609423 3 Novoseek disease relationships for CCL3L1 gene
About this table
1 PharmGKB disease relationship for CCL3L1 gene
| Disease |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| HIV Infections | CO  GN   | 15637236 | About this table
Human Gene Mutation Database: CCL3L1 Human Genome Epidemiology Navigator: CCL3L1 (9 documents)
|
Medical News for CCL3L1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CCL3L1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/44 PubMed articles for CCL3L1 gene (see all 44
):- Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. (PubMed id 1972563)2, 3, 4 Irving S.G....Kelly K. (1990)
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PubMed id 17330138)1, 3, 4 Shao W....Kaslow R.A. (2007)
- Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. (PubMed id 11449371)1, 3, 4 Struyf S.... Van Damme J. (2001)
- Structures of human genes coding for cytokine LD78 and their expression. (PubMed id 1694014)1, 3, 4 Nakao M.... Shimada K. (1990)
- Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. (PubMed id 1296815)1, 2, 3 Hirashima M....Shimada K. (1992)
- The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. (PubMed id 15637236)3, 7 Gonzalez E....Ahuja S.K. (2005)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist. (PubMed id 10961862)3, 4 Proost P....Van Damme J. (2000)
- Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PubMed id 2271120)3, 4 Blum S.... Forsdyke D.R. (1990)
|
Search for CCL3L1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CCL3L1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CCL3L1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCL3L1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CCL3L1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CCL3L1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for CCL3L1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|