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CCL3L1 Gene

protein-coding   GIFtS: 51

GC17M031635
chemokine (C-C motif) ligand 3-like 1
(Previous name: small inducible cytokine A3-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: D17S1718, SCYA3L, SCYA3L1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
464.2 2
D17S1718 2, 3
G0S19-2 1, 2, 3
LD78 2, 5
LD78-beta(1-70) 3
LD78BETA 1, 2
MGC104178 2
MGC12815 2
MGC182017 2
MIP1AP 2
SCYA3L 2
SCYA3L1 2, 3, 5
Descriptions
G0/G1 switch regulatory protein 19-2 3
G0S19-2 protein 3
PAT 464.2 3
Small-inducible cytokine A3-like 1 3
Tonsillar lymphocyte LD78 beta protein 3
chemokine (C-C motif) ligand 3-like 1 2
small inducible cytokine A3-like 1 1, 2
External Ids
HGNC: 106281
Entrez Gene: 63492
UniProtKB: P166193
Ensembl: ENSG000002050177
Search outside databases for aliases for CCL3L1 gene

Previous GC identifers: GC17U990089 GC17M036564 GC17M034769

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCL3L1:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein
binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C
motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5
inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have
1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The
human genome reference assembly contains two full copies of the gene and a partial pseudogene.
This record represents the more telomeric full-length gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619
Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an
inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher
chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a
ligand for CCR1, CCR3 and CCR5

Gene Wiki entry for CCL3L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CCL3L1 gene  

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

CCL3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M031635:     (about GC identifiers)

Start:
31,647,955 bp from pter
End:
31,649,844 bp from pter
Size:
1,890 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010799.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619 (See protein sequence)
Recommended Name: C-C motif chemokine 3-like 1 precursor  
Size: 93 amino acids; 10161 Da
Subcellular location: Secreted
Secondary accessions: A6NGK6 B2RUX4 Q3B7A8 Q53YA5 Q96I68

Post-translational modifications:

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic
    cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is
    probably achieved by DPP41


  • REFSEQ proteins: NP_066286.1  

    ENSEMBL proteins: 
    ENSP00000377981 ENSP00000377982 ENSP00000367597 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for CCL3L1 (CCL3L1/MIP-1 alpha Isoform LD78 beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LD78 beta)
    Human Recombinant Proteins from Abnova (CCL3L1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for CCL3L1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LD78 beta), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for CCL3L1

    Assays for CCL3L1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000827 CC_chemkine_sml_CS
     IPR001811 Chemokine_IL8


       GeneDecks  CCL3L1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P16619

    ProtoNet protein and cluster: P16619

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619
    Similarity: Belongs to the intercrine beta (chemokine CC) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CCL3L1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021006

                  Applied Biosystems Silencer® siRNAs for CCL3L1

                  Sigma-Aldrich siRNA for CCL3L1  
                         Sigma-Aldrich shRNA Panels and shRNA for CCL3L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021006
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021006
                                     untagged cDNA clones in CMV expression vector (see all 2): BC027888 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC027888

    UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619
    Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an
    inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher
    chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a
    ligand for CCR1, CCR3 and CCR5

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/41 Interacting proteins for CCL3L1 (ENSP000003675973) via UniProtKB, MINT, and/or STRING (see all 41 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR5ENSP000002923033STRING (score=.993)
    CCR1ENSP000002961403STRING (score=.98)
    CSF2ENSP000002968713STRING (score=.951)
    CSF1ENSP000003498543STRING (score=.92)
    CCR3ENSP000003500033STRING (score=.917)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CCL3L1
    4 Novoseek chemical compound relationships for CCL3L1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 74.37 5 12355456 (2), 17330138 (2)
    rantes 69.90 4 11287590 (2), 15662971 (1), 10449444 (1)
    ccl4 53.66 2 17330138 (2)
    calcium 0.00 2 10449444 (1), 11449371 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CCL3L1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021006

                  Sigma-Aldrich siRNA for CCL3L1  
                         Sigma-Aldrich shRNA Panels and shRNA for CCL3L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021006  

    REFSEQ mRNAs for CCL3L1 gene: 

    NM_021006.4   


                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021006
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021006
                                     untagged cDNA clones in CMV expression vector (see all 2): BC027888 

    Additional cDNA sequence: 

    BC027888.1 BC107710.1 BC146914.1 BC146919.1 BC147008.1 BC147013.1 X52149.1 

    6 DOTS entries:

    DT.100035793  DT.120948225  DT.449023  DT.97858828  DT.100759261  DT.95371117 

    24/42 AceView cDNA sequences (see all 42 ):

    AA382113 BU626588 AA362364 AA362273 CA430410 NM_021006 R54639 AA366594 
    AA382070 AL543270 AA361985 AA380745 N47995 BM992482 CF128666 AA371389 
    X52149 BC027888 BI839085 AA362365 AA382112 AW959359 AW059858 AV647106 

    highest scoring ESTs for CCL3L1:

    AI348011 AV738689 AA366594 AL543270 AV739733 AW959359 BC027888 BF662985 BI839085 BU626588 

    Unigene Cluster for CCL3L1:

    Chemokine (C-C motif) ligand 3-like 1
    Hs.512683  [show with all ESTs]
    Unigene Representative Sequence: BF662985


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000394469  ENST00000394470  ENST00000378346  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CCL3L1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CCL3L1

    1 / 2 / 3

    3 probe-sets matching CCL3L1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36103_at2, 3 U95-A 4 1.00 0.25 1.00 1.00 D90144 0.20 0.20 0.20 1

    205114_s_at2, 3 U133-A 4 1.00 0.25 -- -- NM_002983 0.20 0.33 0.27 2

    205114_s_at2 U133Plus2 4 1.00 0.25 -- -- -- -- -- -- --
    GeneDecks  CCL3L1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.512683
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CCL3L1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4806001   -- similar to Small inducible cytokine A3-like 1 precursor more 77.42(n)
    68.82(a)
    480600  XM_537720.2  XP_537720.1 
    chimpanzee
    (Pan troglodytes)
    LOC7499131   -- similar to Small inducible cytokine A3-like 1 precursor more 94.27(n)
    92.47(a)
    749913  XM_001172226.1  XP_001172226.1 
    cow
    (Bos taurus)
    CCL31   -- chemokine (C-C motif) ligand 3 81.72(n)
    72.04(a)
    282170  NM_174511.2  NP_776936.1 
    rat
    (Rattus norvegicus)
    Ccl31   -- chemokine (C-C motif) ligand 3 79.71(n)
    77.17(a)
    25542  NM_013025.2  NP_037157.2 
    mouse
    (Mus musculus)
    Ccl31   -- chemokine (C-C motif) ligand 3 78.99(n)
    76.09(a)
    20302  NM_011337.2  NP_035467.1 
    About this table        Species with no ortholog for CCL3L1

    ENSEMBL Gene Tree for CCL3L1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CCL3L1 gene
    CCL3L31 2  LOC7288301 2  ENSG000002156272  CCL142  CCL4L12  CCL4L22  CCL32  CCL52  
    CCL42  CCL182  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: CL3L1_HUMAN, P16619
    Polymorphism: The copy number of the CCL3L1 gene varies among individuals; most individuals have
    1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 601395   disorders: 609423  

    3 Novoseek disease relationships for CCL3L1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 25.14 3 11734558 (1), 17330138 (1), 11287590 (1)
    glioma 23.67 2 15662971 (2)
    aids 22.11 8 19287150 (3)
    About this table

    1 PharmGKB disease relationship for CCL3L1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    HIV InfectionsCO  GN  15637236
    About this table

    Human Gene Mutation Database: CCL3L1
    Human Genome Epidemiology Navigator: CCL3L1 (9 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/44 PubMed articles for CCL3L1 gene (see all 44 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6349 HGNC: 10628 AceView: CCL3L1andCCL3L2 Ensembl:ENSG00000205017 euGenes: HUgn6349
    ECgene: CCL3L1 H-InvDB: CCL3L1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CCL3L1:
     TaqMan ® Gene Expression Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CCL3L1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CCL3L1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CCL3L1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (LD78 beta)
     Antibodies (LD78 beta)
     Search OriGene for CCL3L1
     Search Tocris compounds for CCL3L1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for CCL3L1

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