Aliases for CCL3L1 Gene
Aliases for CCL3L1 Gene
- C-C Motif Chemokine Ligand 3 Like 1 2 3
- Tonsillar Lymphocyte LD78 Beta Protein 3 4
- Chemokine (C-C Motif) Ligand 3-Like 1 2 3
- G0/G1 Switch Regulatory Protein 19-2 3 4
- Small Inducible Cytokine A3-Like 1 2 3
- LD78-Beta(1-70) 3 4
- D17S1718 3 4
- SCYA3L1 3 4
- G0S19-2 3 4
- C-C Motif Chemokine Ligand 3 Like 3 5
- Small-Inducible Cytokine A3-Like 1 4
External Ids for CCL3L1 Gene
- HGNC: 10628
- Entrez Gene: 6349
- Ensembl: ENSG00000276085
- OMIM: 601395
- UniProtKB: P16619
Previous HGNC Symbols for CCL3L1 Gene
- D17S1718
- SCYA3L
- SCYA3L1
Previous GeneCards Identifiers for CCL3L1 Gene
- GC17U990089
- GC17M036564
- GC17M034769
- GC17M031635
- GC17M034522
- GC17M034623
- GC17Mj00250
Summaries for CCL3L1 Gene
-
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for CCL3L1 Gene
CCL3L1 (C-C Motif Chemokine Ligand 3 Like 1) is a Protein Coding gene. Diseases associated with CCL3L1 include Hiv-1 and Asymptomatic Dengue. Among its related pathways are PEDF Induced Signaling and Innate Immune System. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.
UniProtKB/Swiss-Prot for CCL3L1 Gene
-
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L1 Gene
Genomics for CCL3L1 Gene
Regulatory Elements for CCL3L1 Gene
Enhancers for CCL3L1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCL3L1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CCL3L1 Gene
- Chromosome:
- 17
- Start:
- 36,194,869 bp from pter
- End:
- 36,196,758 bp from pter
- Size:
- 1,890 bases
- Orientation:
- Minus strand
Genomic View for CCL3L1 Gene
Genes around CCL3L1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q21.1 by Entrez Gene
- 17q12 alternate reference locus by HGNC
CCL3L1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL3L1 Gene
Proteins for CCL3L1 Gene
-
Protein details for CCL3L1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16619-CL3L1_HUMAN
- Recommended name:
- C-C motif chemokine 3-like 1
- Protein Accession:
- P16619
- A6NGK6
- B2RUX4
- Q3B7A8
- Q53YA5
- Q96I68
Protein attributes for CCL3L1 Gene
- Size:
- 93 amino acids
- Molecular mass:
- 10161 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CCL3L1 Gene
- The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.
Other Protein References for CCL3L1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCL3L1
-
Cloud-Clone Corp. Antibodies for CCL3L1
- antibodies-online Antibodies for CCL3L1: See all 74
- GeneTex CCL3L1 antibody for CCL3L1
Protein Products
- R&D Systems Proteins and Enzymes for CCL3L1 (CCL3L1/MIP-1 alpha Isoform LD78 beta)
-
OriGene Purified Proteins for CCL3L1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3L1
- Origene Custom Protein Services for CCL3L1
- ProSpec Recombinant Proteins for CCL3L1
-
Cloud-Clone Corp. Proteins for CCL3L1
- antibodies-online Proteins for CCL3L1: See all 27
- Search antibodies-online for peptides
- GeneTex Proteins for CCL3L1
-
ProSci Proteins for CCL3L1
Assay Products
- eBioscience Human MIP-1alpha Instant ELISA 128 tests and Human MIP-1beta Instant ELISA 128 tests for CCL3L1
- antibodies-online Kits for CCL3L1: See all 24
No data available for DME Specific Peptides for CCL3L1 Gene
Domains & Families for CCL3L1 Gene
Gene Families for CCL3L1 Gene
- HGNC:
Protein Domains for CCL3L1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P16619- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
No data available for Suggested Antigen Peptide Sequences for CCL3L1 Gene
Function for CCL3L1 Gene
Molecular function for CCL3L1 Gene
- UniProtKB/Swiss-Prot Function:
- Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0008009 | chemokine activity | IBA | -- |
| GO:0048020 | CCR chemokine receptor binding | IBA | -- |
Phenotypes for CCL3L1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL3L1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL3L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL3L1 gene
- Search ViGene Biosciences for CCL3L1
CRISPR Products
-
OriGene CRISPR knockouts for CCL3L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3L1
miRNA for CCL3L1 Gene
- miRTarBase miRNAs that target CCL3L1
miRNA Products
- Search ViGene Biosciences for CCL3L1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CCL3L1
- Browse OriGene Inhibitory RNA Products For CCL3L1
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL3L1 gene
Clone Products
-
OriGene ORF clones in human for CCL3L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCL3L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCL3L1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL3L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL3L1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3L1 Gene
Localization for CCL3L1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL3L1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IBA | -- |
Pathways & Interactions for CCL3L1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | ERK Signaling |
.61
|
|
| 5 | Toll-like Receptor Signaling Pathway | ||
Pathways by source for CCL3L1 Gene
4 Reactome pathways for CCL3L1 Gene
1 R&D Systems pathway for CCL3L1 Gene
27 Qiagen pathways for CCL3L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002548 | monocyte chemotaxis | IBA | -- |
| GO:0006935 | chemotaxis | IEA | -- |
| GO:0006954 | inflammatory response | TAS | 1694014 |
| GO:0006955 | immune response | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for CCL3L1 Gene
Transcripts for CCL3L1 Gene
mRNA/cDNA for CCL3L1 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCL3L1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL3L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3L1
miRNA Products
- Search ViGene Biosciences for CCL3L1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CCL3L1
- Browse OriGene Inhibitory RNA Products For CCL3L1
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL3L1 gene
Clone Products
-
OriGene ORF clones in human for CCL3L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCL3L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCL3L1 Gene
mRNA differential expression in normal tissues according to GTEx for CCL3L1 Gene
This gene is overexpressed in Whole Blood (x6.5).
NURSA nuclear receptor signaling pathways regulating expression of CCL3L1 Gene:
CCL3L1SOURCE GeneReport for Unigene cluster for CCL3L1 Gene:
Hs.512683Evidence on tissue expression from TISSUES for CCL3L1 Gene
- Blood(4.4)
- Nervous system(4.2)
- Spleen(4.1)
- Pancreas(4)
- Bone marrow(2.4)
Primer Products
-
OriGene qPCR primer pairs for CCL3L1
-
OriGene qPCR primer pairs and template standards for CCL3L1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL3L1 Gene
Orthologs for CCL3L1 Gene
No data available for Orthologs for CCL3L1 Gene
Paralogs for CCL3L1 Gene
Paralogs for CCL3L1 Gene
(30) SIMAP similar genes for CCL3L1 Gene using alignment to 2 proteins:
Variants for CCL3L1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L1 Gene
- CL3L1_HUMAN-P16619
- The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.
Gene Damage Index Score:
0.01;
0.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCL3L1 Gene
No data available for Sequence variations from dbSNP and Humsavar for CCL3L1 Gene
Disorders for CCL3L1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hiv-1 |
|
|
| asymptomatic dengue |
|
|
Search CCL3L1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCL3L1
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3L1 Gene
Publications for CCL3L1 Gene
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 22 46 64
- Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. (PMID: 17604289) McKinney C. … Merriman T.R. (Ann. Rheum. Dis. 2008) 3 22 46 64
- Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. (PMID: 11449371) Struyf S. … Van Damme J. (Eur. J. Immunol. 2001) 3 4 22 64
- Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. (PMID: 1296815) Hirashima M. … Shimada K. (DNA Seq. 1992) 2 3 22 64
- Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. (PMID: 1972563) Irving S.G. … Kelly K. (Nucleic Acids Res. 1990) 2 3 4 64
Products for CCL3L1 Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for CCL3L1 (CCL3L1/MIP-1 alpha Isoform LD78 beta)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCL3L1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3L1
- Origene Custom Protein Services for CCL3L1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCL3L1
- Browse OriGene Inhibitory RNA Products For CCL3L1
- OriGene qPCR primer pairs and template standards for CCL3L1
- OriGene qPCR primer pairs for CCL3L1
- OriGene CRISPR knockouts for CCL3L1
- OriGene ORF clones in human for CCL3L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL3L1
- GenScript: Next-day shipping cDNA ORF clone for CCL3L1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCL3L1
- GenScript Custom Assay Services for CCL3L1
- GenScript Custom overexpressing Cell Line Services for CCL3L1
- Browse GenScript CRISPR for CCL3L1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL3L1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCL3L1
- Novus Biologicals proteins and lysates for CCL3L1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CCL3L1
- Cloud-Clone Corp. Antibodies for CCL3L1
- Cloud-Clone Corp. Proteins for CCL3L1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for CCL3L1: See all 74
- antibodies-online Kits for CCL3L1: See all 24
- antibodies-online Proteins for CCL3L1: See all 27
- Search antibodies-online for peptides
- GeneTex CCL3L1 antibody for CCL3L1
- GeneTex Proteins for CCL3L1
- ViGene Biosciences adenoviral particle packaged cDNA for CCL3L1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCL3L1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCL3L1 gene
- Search ViGene Biosciences for CCL3L1
- Search for CCL3L1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CCL3L1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL3L1
- VectorBuilder custom plasmid, inducible vectors for CCL3L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3L1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCL3L1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (115) ProteomicsDB
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- (141) ENCODE
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- (143) Horizon
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- (147) VectorBuilder
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer