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Aliases for CCL3L1 Gene

Aliases for CCL3L1 Gene

  • Chemokine (C-C Motif) Ligand 3-Like 1 2 3
  • SCYA3L1 3 4 6
  • Tonsillar Lymphocyte LD78 Beta Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-2 3 4
  • Small Inducible Cytokine A3-Like 1 2 3
  • LD78-Beta(1-70) 3 4
  • D17S1718 3 4
  • G0S19-2 3 4
  • LD78 3 6
  • Small-Inducible Cytokine A3-Like 1 4
  • C-C Motif Chemokine 3-Like 1 3
  • CCL3L1 CCL3L3 4
  • PAT 464.2 4
  • LD78BETA 3
  • SCYA3L 3
  • MIP1AP 3
  • 464.2 3

External Ids for CCL3L1 Gene

Previous HGNC Symbols for CCL3L1 Gene

  • D17S1718
  • SCYA3L
  • SCYA3L1

Previous GeneCards Identifiers for CCL3L1 Gene

  • GC17U990089
  • GC17M036564
  • GC17M034769
  • GC17M031635
  • GC17M034522
  • GC17M034623

Summaries for CCL3L1 Gene

Entrez Gene Summary for CCL3L1 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL3L1 Gene

CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1) is a Protein Coding gene. Diseases associated with CCL3L1 include acquired immunodeficiency syndrome and hiv-1. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway.

UniProtKB/Swiss-Prot for CCL3L1 Gene

  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Wiki entry for CCL3L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L1 Gene

Genomics for CCL3L1 Gene

Regulatory Elements for CCL3L1 Gene

Genomic Location for CCL3L1 Gene

Start:
250,577 bp from pter
End:
252,465 bp from pter
Size:
1,889 bases
Orientation:
Minus strand

Genomic View for CCL3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for CCL3L1 Gene

Proteins for CCL3L1 Gene

  • Protein details for CCL3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16619-CL3L1_HUMAN
    Recommended name:
    C-C motif chemokine 3-like 1
    Protein Accession:
    P16619
    Secondary Accessions:
    • A6NGK6
    • B2RUX4
    • Q3B7A8
    • Q53YA5
    • Q96I68

    Protein attributes for CCL3L1 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL3L1 Gene

Proteomics data for CCL3L1 Gene at MOPED

Post-translational modifications for CCL3L1 Gene

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Other Protein References for CCL3L1 Gene

Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL3L1 Gene

Domains for CCL3L1 Gene

Gene Families for CCL3L1 Gene

HGNC:
  • CCL :Chemokine ligands

Protein Domains for CCL3L1 Gene

Graphical View of Domain Structure for InterPro Entry

P16619

UniProtKB/Swiss-Prot:

CL3L1_HUMAN :
  • P16619
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3L1: view

No data available for Suggested Antigen Peptide Sequences for CCL3L1 Gene

Function for CCL3L1 Gene

Molecular function for CCL3L1 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL3L1: view

Phenotypes for CCL3L1 Gene

GenomeRNAi human phenotypes for CCL3L1:
genes like me logo Genes that share phenotypes with CCL3L1: view

Animal Model Products

CRISPR Products

miRNA for CCL3L1 Gene

miRTarBase miRNAs that target CCL3L1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL3L1 Gene

Localization for CCL3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3L1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL3L1 Gene COMPARTMENTS Subcellular localization image for CCL3L1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL3L1: view

Pathways for CCL3L1 Gene

genes like me logo Genes that share pathways with CCL3L1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
    • Antiviral Response in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat

Interacting Proteins for CCL3L1 Gene

Selected Interacting proteins: P16619-CL3L1_HUMAN for CCL3L1 Gene via I2D

Gene Ontology (GO) - Biological Process for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 1694014
GO:0006955 immune response IEA --
GO:0008285 negative regulation of cell proliferation TAS 2271120
GO:0060326 cell chemotaxis IEA --
genes like me logo Genes that share ontologies with CCL3L1: view

Compounds for CCL3L1 Gene

(4) Novoseek inferred chemical compound relationships for CCL3L1 Gene

Compound -log(P) Hits PubMed IDs
ccl3 78.1 5
rantes 69.4 4
ccl4 52.7 2
calcium 0 2
genes like me logo Genes that share compounds with CCL3L1: view

Transcripts for CCL3L1 Gene

Unigene Clusters for CCL3L1 Gene

Chemokine (C-C motif) ligand 3-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL3L1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3L1 Gene

No ASD Table

Relevant External Links for CCL3L1 Gene

GeneLoc Exon Structure for
CCL3L1
ECgene alternative splicing isoforms for
CCL3L1

Expression for CCL3L1 Gene

mRNA expression in normal human tissues for CCL3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL3L1 Gene

This gene is overexpressed in Whole Blood (6.5).

SOURCE GeneReport for Unigene cluster for CCL3L1 Gene Hs.512683

genes like me logo Genes that share expressions with CCL3L1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CCL3L1 Gene

Orthologs for CCL3L1 Gene

No data available for Orthologs and Evolution for CCL3L1 Gene

Paralogs for CCL3L1 Gene

genes like me logo Genes that share paralogs with CCL3L1: view

No data available for Paralogs for CCL3L1 Gene

Variants for CCL3L1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L1 Gene

P16619-CL3L1_HUMAN
The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies

Structural Variations from Database of Genomic Variants (DGV) for CCL3L1 Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
dgv3145n71 CNV Gain 21882294
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3148n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv514837 CNV Complex 21397061
nsv820772 CNV Deletion 20802225
dgv545e199 CNV Deletion 23128226
nsv436845 CNV Insertion 17901297
dgv951e1 CNV Complex 17122850
nsv821611 CNV Deletion 20802225
dgv546e199 CNV Deletion 23128226
nsv511598 CNV Loss 21212237
nsv514839 CNV Complex 21397061
nsv471397 CNV Duplication 19718026

Relevant External Links for CCL3L1 Gene

HapMap Linkage Disequilibrium report
CCL3L1
Human Gene Mutation Database (HGMD)
CCL3L1

No data available for Sequence variations from dbSNP and Humsavar for CCL3L1 Gene

Disorders for CCL3L1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CCL3L1 Gene including...

Search for CCL3L1 Gene in MalaCards »

(1) OMIM Diseases for CCL3L1 Gene (601395)

(1) University of Copenhagen DISEASES for CCL3L1 Gene

(3) Novoseek inferred disease relationships for CCL3L1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 24.5 3
glioma 22.4 2
aids 21.5 3

Relevant External Links for CCL3L1

Genetic Association Database (GAD)
CCL3L1
Human Genome Epidemiology (HuGE) Navigator
CCL3L1
genes like me logo Genes that share disorders with CCL3L1: view

No data available for UniProtKB/Swiss-Prot for CCL3L1 Gene

Publications for CCL3L1 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 23 48
  2. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. (PMID: 17604289) McKinney C. … Merriman T.R. (Ann. Rheum. Dis. 2008) 3 23 48
  3. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. (PMID: 1296815) Hirashima M. … Shimada K. (DNA Seq. 1992) 2 3 23
  4. Structures of human genes coding for cytokine LD78 and their expression. (PMID: 1694014) Nakao M. … Shimada K. (Mol. Cell. Biol. 1990) 3 4 23
  5. Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. (PMID: 11449371) Struyf S. … Van Damme J. (Eur. J. Immunol. 2001) 3 4 23

Products for CCL3L1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
    • Antiviral Response in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL3L1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL3L1
    • Block miRNA regulation of CCL3L1 using miScript Target Protectors

    Sources for CCL3L1 Gene

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