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Aliases for CCL3L1 Gene

Aliases for CCL3L1 Gene

  • C-C Motif Chemokine Ligand 3 Like 1 2 3
  • Tonsillar Lymphocyte LD78 Beta Protein 3 4
  • Chemokine (C-C Motif) Ligand 3-Like 1 2 3
  • G0/G1 Switch Regulatory Protein 19-2 3 4
  • Small Inducible Cytokine A3-Like 1 2 3
  • LD78-Beta(1-70) 3 4
  • D17S1718 3 4
  • SCYA3L1 3 4
  • G0S19-2 3 4
  • Small-Inducible Cytokine A3-Like 1 4
  • C-C Motif Chemokine 3-Like 1 3
  • CCL3L1 CCL3L3 4
  • PAT 464.2 4
  • LD78BETA 3
  • MIP1AP 3
  • SCYA3L 3
  • 464.2 3
  • LD78 3

External Ids for CCL3L1 Gene

Previous HGNC Symbols for CCL3L1 Gene

  • D17S1718
  • SCYA3L
  • SCYA3L1

Previous GeneCards Identifiers for CCL3L1 Gene

  • GC17U990089
  • GC17M036564
  • GC17M034769
  • GC17M031635
  • GC17M034522
  • GC17M034623

Summaries for CCL3L1 Gene

Entrez Gene Summary for CCL3L1 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL3L1 Gene

CCL3L1 (C-C Motif Chemokine Ligand 3 Like 1) is a Protein Coding gene. Diseases associated with CCL3L1 include Hiv-1 and Asymptomatic Dengue. Among its related pathways are Immune System and PEDF Induced Signaling. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL3L1 Gene

  • Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Wiki entry for CCL3L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3L1 Gene

Genomics for CCL3L1 Gene

Regulatory Elements for CCL3L1 Gene

Enhancers for CCL3L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F000260 0.4 ENCODE 0.4 -7.9 -7899 0.1 GLIS1 DOC2B GC17P000262 CCL3L1
GH17F000259 0.4 ENCODE 0.4 -7.4 -7399 0.2 GLIS1 DOC2B GC17P000262 CCL3L1
GH17F000261 0.4 ENCODE 0.4 -7.7 -7708 0.3 GLIS1 ZIC2 DOC2B GC17P000262 CCL3L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL3L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL3L1 Gene

Chromosome:
17
Start:
250,577 bp from pter
End:
252,466 bp from pter
Size:
1,890 bases
Orientation:
Minus strand

Genomic View for CCL3L1 Gene

Genes around CCL3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CCL3L1 Gene

Proteins for CCL3L1 Gene

  • Protein details for CCL3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16619-CL3L1_HUMAN
    Recommended name:
    C-C motif chemokine 3-like 1
    Protein Accession:
    P16619
    Secondary Accessions:
    • A6NGK6
    • B2RUX4
    • Q3B7A8
    • Q53YA5
    • Q96I68

    Protein attributes for CCL3L1 Gene

    Size:
    93 amino acids
    Molecular mass:
    10161 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL3L1 Gene

Post-translational modifications for CCL3L1 Gene

  • The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Other Protein References for CCL3L1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for CCL3L1 Gene

Domains & Families for CCL3L1 Gene

Gene Families for CCL3L1 Gene

Protein Domains for CCL3L1 Gene

Graphical View of Domain Structure for InterPro Entry

P16619

UniProtKB/Swiss-Prot:

CL3L1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3L1: view

No data available for Suggested Antigen Peptide Sequences for CCL3L1 Gene

Function for CCL3L1 Gene

Molecular function for CCL3L1 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL3L1: view
genes like me logo Genes that share phenotypes with CCL3L1: view

Animal Model Products

miRNA for CCL3L1 Gene

miRTarBase miRNAs that target CCL3L1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3L1 Gene

Localization for CCL3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL3L1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL3L1: view

Pathways & Interactions for CCL3L1 Gene

genes like me logo Genes that share pathways with CCL3L1: view

Interacting Proteins for CCL3L1 Gene

Gene Ontology (GO) - Biological Process for CCL3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006954 inflammatory response TAS 1694014
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0008285 negative regulation of cell proliferation TAS 2271120
GO:0030593 neutrophil chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL3L1: view

No data available for SIGNOR curated interactions for CCL3L1 Gene

Drugs & Compounds for CCL3L1 Gene

(3) Drugs for CCL3L1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCL3L1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL3L1: view

Transcripts for CCL3L1 Gene

Unigene Clusters for CCL3L1 Gene

Chemokine (C-C motif) ligand 3-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3L1 Gene

No ASD Table

Relevant External Links for CCL3L1 Gene

GeneLoc Exon Structure for
CCL3L1
ECgene alternative splicing isoforms for
CCL3L1

Expression for CCL3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL3L1 Gene

mRNA differential expression in normal tissues according to GTEx for CCL3L1 Gene

This gene is overexpressed in Whole Blood (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of CCL3L1 Gene:

CCL3L1

SOURCE GeneReport for Unigene cluster for CCL3L1 Gene:

Hs.512683
genes like me logo Genes that share expression patterns with CCL3L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCL3L1 Gene

Orthologs for CCL3L1 Gene

No data available for Orthologs and Evolution for CCL3L1 Gene

Paralogs for CCL3L1 Gene

genes like me logo Genes that share paralogs with CCL3L1: view

No data available for Paralogs for CCL3L1 Gene

Variants for CCL3L1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3L1 Gene

CL3L1_HUMAN-P16619
The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.

Structural Variations from Database of Genomic Variants (DGV) for CCL3L1 Gene

Variant ID Type Subtype PubMed ID
dgv5554n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5540n54 CNV loss 21841781
dgv5538n54 CNV gain 21841781
dgv5536n54 CNV gain 21841781
dgv5534n54 CNV gain 21841781
dgv545e199 CNV deletion 23128226
dgv522n67 CNV gain 20364138
dgv3147n100 CNV gain 25217958
dgv3146n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv3143n100 CNV gain 25217958
dgv178n21 CNV loss 19592680
dgv120e55 CNV gain 17911159
nsv960473 CNV duplication 23825009
nsv960470 CNV duplication 23825009
nsv953882 CNV deletion 24416366
nsv833427 CNV loss 17160897
nsv833424 CNV gain 17160897
nsv820772 CNV deletion 20802225
nsv574783 CNV gain 21841781
nsv574781 CNV gain 21841781
nsv574780 CNV gain+loss 21841781
nsv574755 CNV gain 21841781
nsv523265 CNV gain 19592680
nsv514837 CNV gain 21397061
nsv514836 CNV gain 21397061
nsv471397 CNV gain 19718026
nsv471395 CNV gain 19718026
nsv457733 CNV gain 19166990
nsv433448 CNV gain 18776910
nsv2040 CNV deletion 18451855
nsv1160469 CNV duplication 26073780
nsv1143852 CNV deletion 24896259
nsv1133405 CNV deletion 24896259
nsv1072731 CNV deletion 25765185
nsv1066186 CNV gain 25217958
nsv1062304 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1061066 CNV loss 25217958
nsv1059795 CNV gain 25217958
esv3893005 CNV loss 25118596
esv3893001 CNV gain 25118596
esv3893000 CNV gain+loss 25118596
esv3640463 CNV gain 21293372
esv3554365 CNV deletion 23714750
esv3438495 CNV duplication 20981092
esv3397133 CNV duplication 20981092
esv3374119 CNV duplication 20981092
esv3333423 CNV duplication 20981092
esv33166 CNV gain 17666407
esv33107 CNV loss 17666407
esv2762388 CNV gain+loss 21179565
esv2760467 CNV gain 21179565
esv2715876 CNV deletion 23290073
esv2670934 CNV deletion 23128226
esv2664544 CNV deletion 23128226
dgv5557n54 CNV loss 21841781

Variation tolerance for CCL3L1 Gene

Gene Damage Index Score: 0.01; 0.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL3L1 Gene

Human Gene Mutation Database (HGMD)
CCL3L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL3L1

No data available for Sequence variations from dbSNP and Humsavar for CCL3L1 Gene

Disorders for CCL3L1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCL3L1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
asymptomatic dengue
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCL3L1

Genetic Association Database (GAD)
CCL3L1
Human Genome Epidemiology (HuGE) Navigator
CCL3L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL3L1
genes like me logo Genes that share disorders with CCL3L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3L1 Gene

Publications for CCL3L1 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 4 22 46 64
  2. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. (PMID: 17604289) McKinney C. … Merriman T.R. (Ann. Rheum. Dis. 2008) 3 22 46 64
  3. Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. (PMID: 11449371) Struyf S. … Van Damme J. (Eur. J. Immunol. 2001) 3 4 22 64
  4. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. (PMID: 1296815) Hirashima M. … Shimada K. (DNA Seq. 1992) 2 3 22 64
  5. Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. (PMID: 1972563) Irving S.G. … Kelly K. (Nucleic Acids Res. 1990) 2 3 4 64

Products for CCL3L1 Gene

Sources for CCL3L1 Gene

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