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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL3 Gene

protein-coding   GIFtS: 63
GCID: GC17M034415

Chemokine (C-C Motif) Ligand 3

(Previous name: small inducible cytokine A3 (homologous to mouse Mip-1a))
(Previous symbol: SCYA3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 31 2     MIP-1-alpha2 3
SCYA31 2 3 5     SIS-beta2 3
MIP1A2 3 5     G0/G1 Switch Regulatory Protein 19-12 3
Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a)1 2     PAT 464.12 3
Macrophage Inflammatory Protein 1-Alpha2 3     LD78ALPHA2
Tonsillar Lymphocyte LD78 Alpha Protein2 3     C-C Motif Chemokine 32
G0S19-12 3     Small-Inducible Cytokine A33

External Ids:    HGNC: 106271   Entrez Gene: 63482   Ensembl: ENSG000000060757   OMIM: 1822835   UniProtKB: P101473   
ORGUL members:         
NONCODE14:n332780 n333666 n342692      

Export aliases for CCL3 gene to outside databases

Previous GC identifers: GC17M034185 GC17M036451 GC17M034264 GC17M034561 GC17M031439 GC17M030600


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL3 Gene:
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory
protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5.
Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human
immunodeficiency virus type 1.(provided by RefSeq, Sep 2010)

GeneCards Summary for CCL3 Gene: 
CCL3 (chemokine (C-C motif) ligand 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL3 include hiv infection, resistance to, and chromoblastomycosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Toll-like receptor signaling pathway. GO annotations related to this gene include protein kinase activity and kinase activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147
Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major
HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of
different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)

Gene Wiki entry for CCL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL3 gene promoter:
         CREB   AML1a   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

CCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034415:  view genomic region     (about GC identifiers)

Start:
34,415,602 bp from pter      End:
34,417,515 bp from pter
Size:
1,914 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCL3

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147 (See protein sequence)
Recommended Name: C-C motif chemokine 3 precursor  
Size: 92 amino acids; 10085 Da
Subunit: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69)
Subcellular location: Secreted
6/8 PDB 3D structures from and Proteopedia for CCL3 (see all 8):
1B50 (3D)        1B53 (3D)        2X69 (3D)        2X6G (3D)        3FPU (3D)        3H44 (3D)    

Explore the universe of human proteins at neXtProt for CCL3: NX_P10147

Explore proteomics data for CCL3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from
    HTLV1-transformed T-cells
  • View neXtProt modification sites for NX_P10147

  • CCL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL3 Protein Expression
    REFSEQ proteins: NP_002974.1  
    ENSEMBL proteins: 
     ENSP00000225245  
    Reactome Protein details: P10147
    Human Recombinant Protein Products for CCL3: 
    EMD Millipore Purified and/or Recombinant CCL3 Protein
    R&D Systems Recombinant & Natural Proteins for CCL3 (CCL3/MIP-1 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL3
    OriGene Protein Over-expression Lysate for CCL3
    OriGene MassSpec for CCL3 
    OriGene Custom Protein Services for CCL3
    GenScript Purified and Recombinant Proteins for CCL3
    Novus Biologicals CCL3 Proteins
    Novus Biologicals CCL3 Lysates
    Sino Biological Recombinant Protein for CCL3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL3
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA10072545
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA19523456

    CCL3 for ontologies           About GeneDecksing



    CCL3 Antibody Products: 
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    Novus Biologicals CCL3 Antibodies
    Abcam antibodies for CCL3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CCL3
    LSBio Antibodies in human, mouse, rat for CCL3 

    Assay Products for CCL3: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for CCL3 (CCL3/MIP-1 alpha)         (see all)
    GenScript Custom Assay Services for CCL3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P10147

    ProtoNet protein and cluster: P10147

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL3_HUMAN, P10147
    Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major
    HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of
    different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)
    Induction: By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin
    (T-cell mitogen))

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10734056
    GO:0004698calcium-dependent protein kinase C activity IDA15764707
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity IDA10072545
    GO:0016004phospholipase activator activity IDA10734056
         
    CCL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL3:
     Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl3):
     behavior/neurological  cellular  digestive/alimentary  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system 

    CCL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl3tm1Unc for CCL3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL3 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidCCL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL3

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CCL3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL3 (see all 7)
    OriGene ORF clones in mouse, rat for CCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL3 (NM_002983)
    Sino Biological Human cDNA Clone for CCL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL3
    Sirion Biotech Customized lentivirus for stable overexpression of CCL3 
                         Customized lentivirus expression plasmids for stable overexpression of CCL3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL3
    Search LifeMap BioReagents cell lines for CCL3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL3 About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL3
        Selected targets of C/EBPbeta

    1 R&D Systems Pathway for CCL3
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL3 (see all 29)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    3 BioSystems Pathways for CCL3
        Senescence and Autophagy
    Toll-like receptor signaling pathway
    IL12-mediated signaling events


    5/6        Reactome Pathways for CCL3 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    5/6         Kegg Pathways  (Kegg details for CCL3) (see all 6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    Salmonella infection
    Chagas disease (American trypanosomiasis)


    CCL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for CCL3 (P101472, 3 ENSP000002252454) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IDEP147352, 3, ENSP000002659864MINT-8087623 MINT-8087747 MINT-8087595 I2D: score=1 STRING: ENSP00000265986
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0001649osteoblast differentiation IEP--
    GO:0001775cell activation IDA10706735
    GO:0002548monocyte chemotaxis IDA10706735
    GO:0006468protein phosphorylation IDA10734056

    CCL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL3

    10/106 Novoseek inferred chemical compound relationships for CCL3 gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 97.5 1169 8616572 (6), 11861332 (6), 9417081 (6), 9746565 (6) (see all 99)
    ccl3 95.3 411 17357337 (9), 20047691 (7), 18619972 (7), 19055602 (7) (see all 99)
    mip 1alpha 87.3 29 18403790 (5), 16211583 (3), 11097208 (2), 20205697 (2) (see all 18)
    ccl4 78.3 152 15585374 (3), 19383907 (3), 16773571 (3), 18447713 (2) (see all 89)
    groalpha 76.6 19 10437780 (2), 10337033 (2), 20308302 (1), 11598150 (1) (see all 13)
    tarc 73.3 18 15941911 (2), 9169480 (2), 15488706 (1), 19270434 (1) (see all 13)
    peedck 63.5 2 1949198 (1), 1343739 (1)
    larc 62.7 9 18492658 (2), 16911361 (1), 9153236 (1), 9169480 (1) (see all 7)
    mcp 1 62.4 8 20205697 (2), 15660413 (1), 11683586 (1), 16918500 (1) (see all 5)
    il 10 53.4 6 9851514 (1), 18403790 (1), 11240512 (1), 15544634 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CCL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL3 gene: 
    NM_002983.2  

    Unigene Cluster for CCL3:

    Chemokine (C-C motif) ligand 3
    Hs.514107  [show with all ESTs]
    Unigene Representative Sequence: AL575305
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225245 ENST00000470334(uc002hkv.3) ENST00000585830
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL3 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidCCL3 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL3 (NM_002983)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL3
    Sirion Biotech Customized lentivirus for stable overexpression of CCL3 
                         Customized lentivirus expression plasmids for stable overexpression of CCL3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL3

    Additional mRNA sequence: 

    AF043339.1 BC071834.1 BC171831.1 BC171891.1 D00044.1 D63785.1 M23452.1 M25315.1 
    X03754.1 

    6 DOTS entries:

    DT.100035793  DT.449023  DT.97858828  DT.100759261  DT.91762186  DT.92038815 

    24/125 AceView cDNA sequences (see all 125):

    AA361920 CR591007 BM918492 BM923819 AA382197 M23452 BX103455 AA381205 
    AA382200 CA431873 AF043339 CR620842 CR595320 CR591252 AA864342 M25315 
    AA894533 CB242004 AA382124 CB241475 CA449967 BM673241 BX356973 AA362355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL3 expression in normal human tissues (normalized intensities)      CCL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCL3 Expression
    About this image


    CCL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Peripheral Blood Immature Myeloid Dendritic Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood Natural Killer Cells (CD56+)   
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes (HEM)   

    See CCL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL3

    SOURCE GeneReport for Unigene cluster: Hs.514107
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL3 (see all 14): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL3
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl35 chemokine (C-C motif) ligand 3   --   11 (51.04 cM) 83647844 
    chicken
    (Gallus gallus)
    Aves --
    CCLI106
    Chemokine; Uncharacterized protein
    40(a)
    37(a)
    many ↔ many
    many ↔ many
    19(4812218-4813843)
    19(4792410-4793550)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.36
    si:dkeyp-59a8.26
    (see all 5)
    si:dkeyp-59a8.2
    (see all 5)
    28(a)
    27(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38310380-38311158)
    20(38304232-38305101)


    ENSEMBL Gene Tree for CCL3 (if available)
    TreeFam Gene Tree for CCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL3 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL52  
    CCL232  CCL3L32  CCL15-CCL142  CCL42  CCL182  
    18/28 SIMAP similar genes for CCL3 using alignment to 2 protein entries:     CCL3_HUMAN (see all proteins) (see all similar genes):
    CCL3L1    CCL3L3    CCL4    CCL4L2    LOC728835    CCL14
    CCL4L1    CCL18    CCL16    CCL5    CCL7    MCP-3
    CCL11    CCL13    CCL15    CCL2    CCL26    CCL8

    CCL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCL3
    PGOHUM00000262953


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in CCL3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0487014
    ----see VAR_0487012 E D mis40--------
    rs30622421,2
    C--34418394(+) tatat-/A/ATAT
            
    ttgta
    1 -- us2k10--------
    rs3688796341,2
    ----30602943(+) TATATA/TTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL3 (34415602 - 34417515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for CCL3 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664544CNV Deletion23128226
    esv2670934CNV Deletion23128226
    nsv471395CNV Duplication19718026
    nsv833427CNV Loss17160897
    dgv178n21CNV Loss19592680
    esv33166CNV Gain17666407
    dgv522n67CNV Gain20364138
    dgv3144n71CNV Gain21882294
    dgv3143n71CNV Gain21882294
    nsv514836CNV Gain21397061

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182283   
    OMIM disorders: 609423  
    20/183 diseases for CCL3 (see all 183):    About MalaCards
    hiv infection, resistance to    chromoblastomycosis    stachybotrys chartarum    african tick-bite fever
    acid sphingomyelinase deficiency    lyme disease    alexithymia    aseptic meningitis
    mast-cell leukemia    crescentic glomerulonephritis    toxic shock syndrome    pulmonary eosinophilia
    poems syndrome    pleurisy    tuberculous meningitis    meningitis
    periapical granuloma    genital herpes    htlv-1 associated myelopathy    pulmonary fibrosis

    5 diseases from the University of Copenhagen DISEASES database for CCL3:
    Lung disease     Human immunodeficiency virus infectious disease     Multiple sclerosis     Arthritis
    Multiple myeloma

    CCL3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for CCL3 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.1 266 14693736 (2), 14586377 (2), 20396789 (2), 11083814 (2) (see all 99)
    inflammation 70.6 63 10209033 (2), 9841832 (2), 11803002 (2), 7509730 (1) (see all 46)
    bone destruction 61.1 19 15043189 (4), 11748267 (3), 16263571 (1), 16982321 (1) (see all 9)
    immunodeficiency 59.3 46 9359702 (2), 10979927 (2), 8570619 (1), 9870314 (1) (see all 38)
    hiv infections 56 22 11120614 (3), 10875609 (1), 18332855 (1), 18221152 (1) (see all 16)
    bronchoalveolar lavage fluid 53.4 20 8616572 (1), 15802346 (1), 11790661 (1), 12449175 (1) (see all 18)
    tumors 51.6 283 15139590 (5), 12649140 (4), 10679114 (2), 14693736 (2) (see all 99)
    myeloma 51.2 60 16263571 (5), 12548580 (4), 15043189 (4), 15730850 (4) (see all 25)
    bone diseases 50.5 27 14510950 (4), 17022050 (2), 11748267 (2), 16263571 (1) (see all 12)
    virus infection 44.5 14 18492658 (1), 10501489 (1), 17547763 (1), 10669379 (1) (see all 13)

    Genetic Association Database (GAD): CCL3
    Human Genome Epidemiology (HuGE) Navigator: CCL3 (28 documents)

    Export disorders for CCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL3 gene, integrated from 9 sources (see all 1410):
    (articles sorted by number of sources associating them with CCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PubMed id 19055602)1, 4, 9 Paximadis M....Tiemessen C.T. (2009)
    2. Macrophage inflammatory protein-1. (PubMed id 12401480)1, 2, 9 Menten P.... Van Damme J. (2002)
    3. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PubMed id 18242850)1, 4, 9 Li K....Wang B. (2008)
    4. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PubMed id 17330138)1, 4, 9 Shao W....Kaslow R.A. (2007)
    5. Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients. (PubMed id 12408680)1, 4, 9 Omori K....Gejyo F. (2002)
    6. Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP- 1beta, and RANTES. Characterization of active disaggregated chemokine variants. (PubMed id 10347159)1, 2, 9 Czaplewski L.G.... Hunter M.G. (1999)
    7. Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese. (PubMed id 17625600)1, 4, 9 Chu S.F....Chiang A.K. (2007)
    8. MCP-1 and MIP-1A gene polymorphisms in Japanese patients with sarcoidosis. (PubMed id 12413001)1, 4, 9 Takada T....Gejyo F. (2002)
    9. Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PubMed id 2271120)1, 2, 9 Blum S.... Forsdyke D.R. (1990)
    10. Structures of human genes coding for cytokine LD78 and their expression. (PubMed id 1694014)1, 2, 9 Nakao M.... Shimada K. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6348 HGNC: 10627 AceView: CCL3 Ensembl:ENSG00000006075 euGenes: HUgn6348
    ECgene: CCL3 Kegg: 6348 H-InvDB: CCL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL3 gene:
    Search GeneIP for patents involving CCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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