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Aliases for CCL3 Gene

Aliases for CCL3 Gene

  • C-C Motif Chemokine Ligand 3 2 3
  • Chemokine (C-C Motif) Ligand 3 2 3 5
  • Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a) 2 3
  • Macrophage Inflammatory Protein 1-Alpha 3 4
  • Tonsillar Lymphocyte LD78 Alpha Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-1 3 4
  • MIP-1-Alpha 3 4
  • PAT 464.1 3 4
  • SIS-Beta 3 4
  • G0S19-1 3 4
  • SCYA3 3 4
  • MIP1A 3 4
  • Small-Inducible Cytokine A3 4
  • LD78ALPHA 3

External Ids for CCL3 Gene

Previous HGNC Symbols for CCL3 Gene

  • SCYA3

Previous GeneCards Identifiers for CCL3 Gene

  • GC17M034185
  • GC17M036451
  • GC17M034264
  • GC17M034561
  • GC17M031439
  • GC17M034415
  • GC17M030600

Summaries for CCL3 Gene

Entrez Gene Summary for CCL3 Gene

  • This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

GeneCards Summary for CCL3 Gene

CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include hiv-1 and rheumatoid arthritis. Among its related pathways are Toll-like receptor signaling pathway and Chemokine Signaling. GO annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot for CCL3 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Gene Wiki entry for CCL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3 Gene

Genomics for CCL3 Gene

Regulatory Elements for CCL3 Gene

Enhancers for CCL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL3 on UCSC Golden Path with GeneCards custom track

Promoters for CCL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL3 Gene

Chromosome:
17
Start:
36,088,256 bp from pter
End:
36,090,169 bp from pter
Size:
1,914 bases
Orientation:
Minus strand

Genomic View for CCL3 Gene

Genes around CCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL3 Gene

Proteins for CCL3 Gene

  • Protein details for CCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10147-CCL3_HUMAN
    Recommended name:
    C-C motif chemokine 3
    Protein Accession:
    P10147

    Protein attributes for CCL3 Gene

    Size:
    92 amino acids
    Molecular mass:
    10085 Da
    Quaternary structure:
    • Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL3 Gene

neXtProt entry for CCL3 Gene

Proteomics data for CCL3 Gene at MOPED

Post-translational modifications for CCL3 Gene

  • N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.

Other Protein References for CCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL3 (CCL3/MIP-1 alpha)

No data available for DME Specific Peptides for CCL3 Gene

Domains & Families for CCL3 Gene

Gene Families for CCL3 Gene

Protein Domains for CCL3 Gene

Suggested Antigen Peptide Sequences for CCL3 Gene

Graphical View of Domain Structure for InterPro Entry

P10147

UniProtKB/Swiss-Prot:

CCL3_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3: view

Function for CCL3 Gene

Molecular function for CCL3 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
UniProtKB/Swiss-Prot Induction:
By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).
genes like me logo Genes that share phenotypes with CCL3: view

Animal Model Products

miRNA for CCL3 Gene

miRTarBase miRNAs that target CCL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3 Gene

Localization for CCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL3 Gene COMPARTMENTS Subcellular localization image for CCL3 gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CCL3 Gene

Pathways & Interactions for CCL3 Gene

genes like me logo Genes that share pathways with CCL3: view

Interacting Proteins for CCL3 Gene

Gene Ontology (GO) - Biological Process for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001649 osteoblast differentiation IEP 21403648
GO:0001775 cell activation IDA 10706735
GO:0002548 monocyte chemotaxis IDA 10706735
GO:0006816 calcium ion transport IDA 10734056
genes like me logo Genes that share ontologies with CCL3: view

No data available for SIGNOR curated interactions for CCL3 Gene

Drugs & Compounds for CCL3 Gene

(51) Drugs for CCL3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ROX-888 Investigational Pharma Target 0

(56) Additional Compounds for CCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL3: view

Transcripts for CCL3 Gene

mRNA/cDNA for CCL3 Gene

Unigene Clusters for CCL3 Gene

Chemokine (C-C motif) ligand 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3 Gene

No ASD Table

Relevant External Links for CCL3 Gene

GeneLoc Exon Structure for
CCL3
ECgene alternative splicing isoforms for
CCL3

Expression for CCL3 Gene

mRNA expression in normal human tissues for CCL3 Gene

mRNA differential expression in normal tissues according to GTEx for CCL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

SOURCE GeneReport for Unigene cluster for CCL3 Gene Hs.514107

genes like me logo Genes that share expression patterns with CCL3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCL3 Gene

Orthologs for CCL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC616364 35
  • 80.95 (n)
  • 75.71 (a)
dog
(Canis familiaris)
Mammalia LOC480600 35
  • 78.99 (n)
  • 69.57 (a)
chimpanzee
(Pan troglodytes)
Mammalia CCL3 35
  • 98.19 (n)
  • 96.74 (a)
Species with no ortholog for CCL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL3 Gene

ENSEMBL:
Gene Tree for CCL3 (if available)
TreeFam:
Gene Tree for CCL3 (if available)

Paralogs for CCL3 Gene

genes like me logo Genes that share paralogs with CCL3: view

Variants for CCL3 Gene

Sequence variations from dbSNP and Humsavar for CCL3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34171309 - 36,088,717(-) AGTGA(G/T)GAGTG reference, missense
rs8951 -- 36,088,374(+) CAGGC(C/T)GATGA utr-variant-3-prime
rs1634497 -- 36,091,599(+) TTTCC(A/G)TACTT upstream-variant-2KB
rs1049114 -- 36,088,699(-) AAATA(C/T)GTCAG reference, synonymous-codon
rs1049121 -- 36,088,693(-) GTCAG(C/T)GACCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCL3 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv120e55 CNV Gain 17911159
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv457733 CNV Gain 19166990
nsv9540 CNV Gain+Loss 18304495
essv19054 CNV CNV 17122850
esv29264 CNV Gain+Loss 19812545
nsv908082 CNV Gain 21882294
dgv3143n71 CNV Gain 21882294
dgv3144n71 CNV Gain 21882294
esv2670934 CNV Deletion 23128226
dgv522n67 CNV Gain 20364138
esv2664544 CNV Deletion 23128226
nsv523265 CNV Gain 19592680
dgv178n21 CNV Loss 19592680
dgv3145n71 CNV Gain 21882294
nsv471395 CNV Duplication 19718026
nsv514836 CNV Gain 21397061
esv33166 CNV Gain 17666407

Variation tolerance for CCL3 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL3 Gene

HapMap Linkage Disequilibrium report
CCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3 Gene

Disorders for CCL3 Gene

MalaCards: The human disease database

(24) MalaCards diseases for CCL3 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
rheumatoid arthritis
  • rheumatoid arthritis, progression of
pneumonia
  • acute pneumonia
bronchiolitis
myeloma
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards
Search CCL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL3

Genetic Association Database (GAD)
CCL3
Human Genome Epidemiology (HuGE) Navigator
CCL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL3
genes like me logo Genes that share disorders with CCL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3 Gene

Publications for CCL3 Gene

  1. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PMID: 19055602) Paximadis M. … Tiemessen C.T. (Int. J. Immunogenet. 2009) 3 23 48 67
  2. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. (PMID: 20015995) Nobile C. … Sol-Foulon N. (J. Virol. 2010) 3 23
  3. TLR activation pathways in HIV-1-exposed seronegative individuals. (PMID: 20124101) Biasin M. … Clerici M. (J. Immunol. 2010) 3 23
  4. Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages. (PMID: 18802359) Ichiyama T. … Furukawa S. (Int. Arch. Allergy Immunol. 2009) 3 23
  5. High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. (PMID: 19074730) Burger J.A. … Rosenwald A. (Blood 2009) 3 23

Products for CCL3 Gene

Sources for CCL3 Gene

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