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CCL3 Gene

protein-coding   GIFtS: 62
GCID: GC17M034415

Chemokine (C-C Motif) Ligand 3

(Previous name: small inducible cytokine A3 (homologous to mouse Mip-1a))
(Previous symbol: SCYA3)
  See CCL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 31 2     MIP-1-alpha2 3
SCYA31 2 3 5     SIS-beta2 3
MIP1A2 3 5     G0/G1 Switch Regulatory Protein 19-12 3
Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a)1 2     PAT 464.12 3
Macrophage Inflammatory Protein 1-Alpha2 3     LD78ALPHA2
Tonsillar Lymphocyte LD78 Alpha Protein2 3     C-C Motif Chemokine 32
G0S19-12 3     Small-Inducible Cytokine A33

External Ids:    HGNC: 106271   Entrez Gene: 63482   Ensembl: ENSG000000060757   OMIM: 1822835   UniProtKB: P101473   
ORGUL members:         

Export aliases for CCL3 gene to outside databases

Previous GC identifers: GC17M034185 GC17M036451 GC17M034264 GC17M034561 GC17M031439 GC17M030600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL3 Gene:
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory
protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5.
Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human
immunodeficiency virus type 1.(provided by RefSeq, Sep 2010)

GeneCards Summary for CCL3 Gene:
CCL3 (chemokine (C-C motif) ligand 3) is a protein-coding gene. Diseases associated with CCL3 include chromoblastomycosis, and african tick-bite fever. GO annotations related to this gene include identical protein binding and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147
Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major
HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of
different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)

Gene Wiki entry for CCL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187661.1  NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL3 gene promoter:
         CREB   AML1a   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL3 promoter sequence
   Search Chromatin IP Primers for CCL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

CCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034415:  view genomic region     (about GC identifiers)

Start:
34,415,602 bp from pter      End:
34,417,515 bp from pter
Size:
1,914 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCL3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147 (See protein sequence)
Recommended Name: C-C motif chemokine 3 precursor  
Size: 92 amino acids; 10085 Da
Subunit: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69)
Selected PDB 3D structures from and Proteopedia for CCL3 (see all 8):
1B50 (3D)        1B53 (3D)        2X69 (3D)        2X6G (3D)        3FPU (3D)        3H44 (3D)    

Explore the universe of human proteins at neXtProt for CCL3: NX_P10147

Explore proteomics data for CCL3 at MOPED

Post-translational modifications: 

  • N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from
    HTLV1-transformed T-cells1
  • Modification sites at neXtProt

  • See CCL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002974.1  
    ENSEMBL proteins: 
     ENSP00000225245  
    Reactome Protein details: P10147

    CCL3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCL3 Protein
    R&D Systems Recombinant & Natural Proteins for CCL3 (CCL3/MIP-1 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CCL3
    OriGene Protein Over-expression Lysate for CCL3
    OriGene MassSpec for CCL3
    OriGene Custom Protein Services for CCL3
    GenScript Purified and Recombinant Proteins for CCL3
    Novus Biologicals CCL3 Proteins
    Novus Biologicals CCL3 Lysates
    Sino Biological Recombinant Protein for CCL3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL3
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL3 

     
    antibodies-online proteins for CCL3 (101 products) 

     
    antibodies-online peptides for CCL3

    CCL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL3 (CCL3/MIP-1 alpha)
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    Novus Biologicals CCL3 Antibodies
    Abcam antibodies for CCL3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL3
    antibodies-online antibodies for CCL3 (190 products) 

    CCL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for CCL3 (CCL3/MIP-1 alpha)         (see all)
    GenScript Custom Assay Services for CCL3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL3 
    antibodies-online kits for CCL3 (58 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P10147

    ProtoNet protein and cluster: P10147

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL3_HUMAN, P10147
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL3_HUMAN, P10147
    Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major
    HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of
    different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)
    Induction: By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin
    (T-cell mitogen))

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10734056
    GO:0004698calcium-dependent protein kinase C activity IDA15764707
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity IDA10072545
    GO:0016004phospholipase activator activity IDA10734056
         
    Find genes that share ontologies with CCL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL3:
     Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl3):
     behavior/neurological  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system 

    Find genes that share phenotypes with CCL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccl3tm1Unc for CCL3

       genOway: Develop your customized and physiologically relevant rodent model for CCL3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CCL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL3 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidCCL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL3
    Predesigned siRNA for gene silencing in human, mouse, rat CCL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL3

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL3 (see all 7)
    OriGene ORF clones in mouse, rat for CCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL3 (NM_002983)
    Sino Biological Human cDNA Clone for CCL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA4-10821) for CCL3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL3_HUMAN, P10147: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    endosome1
    lysosome1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA10072545
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA19523456

    Find genes that share ontologies with CCL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL3 About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with CCL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CCL3
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL3 (see all 29)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    4 BioSystems Pathways for CCL3
        Senescence and Autophagy
    Toll-like receptor signaling pathway
    IL12-mediated signaling events
    Regulation of toll-like receptor signaling pathway


    1 Reactome Pathway for CCL3
        Chemokine receptors bind chemokines


    Selected Kegg Pathways  (Kegg details for CCL3) (see all 6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway
    Salmonella infection
    Chagas disease (American trypanosomiasis)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL3 (see all 14): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL3 (P101471, 2, 3 ENSP000002252454) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IDEP147351, 2, 3, ENSP000002659864EBI-8459634,EBI-2556886 MINT-8087623 MINT-8087747 MINT-8087595 I2D: score=1 STRING: ENSP00000265986
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
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    Gene Ontology (GO): Selected biological process terms (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0001649osteoblast differentiation IEP--
    GO:0001775cell activation IDA10706735
    GO:0002548monocyte chemotaxis IDA10706735
    GO:0006468protein phosphorylation IDA10734056

    Find genes that share ontologies with CCL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL3

    Selected Novoseek inferred chemical compound relationships for CCL3 gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 97.5 1169 8616572 (6), 11861332 (6), 9417081 (6), 9746565 (6) (see all 99)
    ccl3 95.3 411 17357337 (9), 20047691 (7), 18619972 (7), 19055602 (7) (see all 99)
    mip 1alpha 87.3 29 18403790 (5), 16211583 (3), 11097208 (2), 20205697 (2) (see all 18)
    ccl4 78.3 152 15585374 (3), 19383907 (3), 16773571 (3), 18447713 (2) (see all 89)
    groalpha 76.6 19 10437780 (2), 10337033 (2), 20308302 (1), 11598150 (1) (see all 13)
    tarc 73.3 18 15941911 (2), 9169480 (2), 15488706 (1), 19270434 (1) (see all 13)
    peedck 63.5 2 1949198 (1), 1343739 (1)
    larc 62.7 9 18492658 (2), 16911361 (1), 9153236 (1), 9169480 (1) (see all 7)
    mcp 1 62.4 8 20205697 (2), 15660413 (1), 11683586 (1), 16918500 (1) (see all 5)
    il 10 53.4 6 9851514 (1), 18403790 (1), 11240512 (1), 15544634 (1) (see all 5)



    Find genes that share compounds with CCL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL3 gene: 
    NM_002983.2  

    Unigene Cluster for CCL3:

    Chemokine (C-C motif) ligand 3
    Hs.514107  [show with all ESTs]
    Unigene Representative Sequence: AL575305
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225245 ENST00000470334(uc002hkv.3) ENST00000585830
    miRNA
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    Block miRNA regulation of human, mouse, rat CCL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL3 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidCCL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCL3
    Clone
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    OriGene ORF clones in mouse, rat for CCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL3 (NM_002983)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL3
      QuantiTect SYBR Green Assays in human, mouse, rat CCL3
      QuantiFast Probe-based Assays in human, mouse, rat CCL3
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-10821) for CCL3 

    Additional mRNA sequence: 

    AF043339.1 BC071834.1 BC171831.1 BC171891.1 D00044.1 D63785.1 M23452.1 M25315.1 
    X03754.1 

    6 DOTS entries:

    DT.100035793  DT.449023  DT.97858828  DT.100759261  DT.91762186  DT.92038815 

    Selected AceView cDNA sequences (see all 125):

    CR591007 AA362355 M23452 BX103455 BM673241 AA382124 AA382200 AA382197 
    BM923819 CB241475 AA864342 AA894533 CR591252 CB242004 AA362356 AA361920 
    CR595320 CR620842 CA431873 CA449967 M25315 AA381205 BM918492 BX356973 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCL3 Expression
    About this image


    CCL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    CCL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514107
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL3 (see all 14): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL3
    QuantiTect SYBR Green Assays in human, mouse, rat CCL3
    QuantiFast Probe-based Assays in human, mouse, rat CCL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl35 chemokine (C-C motif) ligand 3   --   11 (51.04 cM) 83647844 
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    34(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378


    ENSEMBL Gene Tree for CCL3 (if available)
    TreeFam Gene Tree for CCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL3 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL52  
    CCL232  CCL3L32  CCL15-CCL142  CCL182  CCL42  
    Selected SIMAP similar genes for CCL3 using alignment to 2 protein entries:     CCL3_HUMAN (see all proteins) (see all similar genes):
    CCL3L1    CCL3L3    CCL4    CCL4L2    LOC728835    CCL14
    CCL4L1    CCL18    CCL16    CCL5    CCL7    MCP-3
    CCL11    CCL13    CCL15    CCL2    CCL26    CCL8

    Find genes that share paralogs with CCL3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCL3
    PGOHUM00000262953


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for CCL3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30622421,2
    C--34418394(+) tatat-/A/ATAT
            
    ttgta
    1 -- us2k10--------
    rs341713091,2,4
    ----see VAR_0487012 mis40--------
    rs3688796341,2
    ----30602943(+) TATATA/TTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL3 (34415602 - 34417515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCL3 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664544CNV Deletion23128226
    esv2670934CNV Deletion23128226
    nsv471395CNV Duplication19718026
    nsv833427CNV Loss17160897
    dgv178n21CNV Loss19592680
    esv33166CNV Gain17666407
    dgv522n67CNV Gain20364138
    dgv3144n71CNV Gain21882294
    dgv3143n71CNV Gain21882294
    nsv514836CNV Gain21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182283   
    OMIM disorders: 609423  
    14 diseases for CCL3:    
    About MalaCards
    chromoblastomycosis    african tick-bite fever    stachybotrys chartarum    generalized pustular psoriasis
    stenotrophomonas maltophilia    aseptic meningitis    tuberculous meningitis    alexithymia
    periapical granuloma    genital herpes    pulmonary fibrosis    tuberculosis
    behcet's disease    malaria

    5 diseases from the University of Copenhagen DISEASES database for CCL3:
    Lung disease     Human immunodeficiency virus infectious disease     Multiple sclerosis     Arthritis
    Multiple myeloma

    Find genes that share disorders with CCL3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL3 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.1 266 14693736 (2), 14586377 (2), 20396789 (2), 11083814 (2) (see all 99)
    inflammation 70.6 63 10209033 (2), 9841832 (2), 11803002 (2), 7509730 (1) (see all 46)
    bone destruction 61.1 19 15043189 (4), 11748267 (3), 16263571 (1), 16982321 (1) (see all 9)
    immunodeficiency 59.3 46 9359702 (2), 10979927 (2), 8570619 (1), 9870314 (1) (see all 38)
    hiv infections 56 22 11120614 (3), 10875609 (1), 18332855 (1), 18221152 (1) (see all 16)
    bronchoalveolar lavage fluid 53.4 20 8616572 (1), 15802346 (1), 11790661 (1), 12449175 (1) (see all 18)
    tumors 51.6 283 15139590 (5), 12649140 (4), 10679114 (2), 14693736 (2) (see all 99)
    myeloma 51.2 60 16263571 (5), 12548580 (4), 15043189 (4), 15730850 (4) (see all 25)
    bone diseases 50.5 27 14510950 (4), 17022050 (2), 11748267 (2), 16263571 (1) (see all 12)
    virus infection 44.5 14 18492658 (1), 10501489 (1), 17547763 (1), 10669379 (1) (see all 13)

    Genetic Association Database (GAD): CCL3
    Human Genome Epidemiology (HuGE) Navigator: CCL3 (28 documents)

    Export disorders for CCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL3 gene, integrated from 10 sources (see all 1416):
    (articles sorted by number of sources associating them with CCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PubMed id 19055602)1, 4, 9 Paximadis M....Tiemessen C.T. (Int. J. Immunogenet. 2009)
    2. Macrophage inflammatory protein-1. (PubMed id 12401480)1, 2, 9 Menten P.... Van Damme J. (Cytokine Growth Factor Rev. 2002)
    3. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PubMed id 18242850)1, 4, 9 Li K....Wang B. (Neurosci. Lett. 2008)
    4. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PubMed id 17330138)1, 4, 9 Shao W.... Kaslow R.A. (Genes Immun. 2007)
    5. Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients. (PubMed id 12408680)1, 4, 9 Omori K....Gejyo F. (Amyloid 2002)
    6. Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP- 1beta, and RANTES. Characterization of active disaggregated chemokine variants. (PubMed id 10347159)1, 2, 9 Czaplewski L.G.... Hunter M.G. (J. Biol. Chem. 1999)
    7. Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese. (PubMed id 17625600)1, 4, 9 Chu S.F....Chiang A.K. (Genes Immun. 2007)
    8. MCP-1 and MIP-1A gene polymorphisms in Japanese patients with sarcoidosis. (PubMed id 12413001)1, 4, 9 Takada T....Gejyo F. (Intern. Med. 2002)
    9. Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PubMed id 2271120)1, 2, 9 Blum S.... Forsdyke D.R. (DNA Cell Biol. 1990)
    10. Structures of human genes coding for cytokine LD78 and their expression. (PubMed id 1694014)1, 2, 9 Nakao M.... Shimada K. (Mol. Cell. Biol. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6348 HGNC: 10627 AceView: CCL3 Ensembl:ENSG00000006075 euGenes: HUgn6348
    ECgene: CCL3 Kegg: 6348 H-InvDB: CCL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL3 gene:
    Search GeneIP for patents involving CCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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