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Aliases for CCL3 Gene

Aliases for CCL3 Gene

  • C-C Motif Chemokine Ligand 3 2 3 5
  • Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a) 2 3
  • Macrophage Inflammatory Protein 1-Alpha 3 4
  • Tonsillar Lymphocyte LD78 Alpha Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-1 3 4
  • Chemokine (C-C Motif) Ligand 3 2 3
  • MIP-1-Alpha 3 4
  • PAT 464.1 3 4
  • SIS-Beta 3 4
  • G0S19-1 3 4
  • SCYA3 3 4
  • MIP1A 3 4
  • Small-Inducible Cytokine A3 4
  • C-C Motif Chemokine 3 3
  • LD78ALPHA 3

External Ids for CCL3 Gene

Previous HGNC Symbols for CCL3 Gene

  • SCYA3

Previous GeneCards Identifiers for CCL3 Gene

  • GC17M034185
  • GC17M036451
  • GC17M034264
  • GC17M034561
  • GC17M031439
  • GC17M034415
  • GC17M030600

Summaries for CCL3 Gene

Entrez Gene Summary for CCL3 Gene

  • This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

GeneCards Summary for CCL3 Gene

CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Hiv-1 and Rheumatoid Arthritis. Among its related pathways are Immune System and Toll-like receptor signaling pathway. GO annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L3.

UniProtKB/Swiss-Prot for CCL3 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Gene Wiki entry for CCL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3 Gene

Genomics for CCL3 Gene

Regulatory Elements for CCL3 Gene

Enhancers for CCL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036149 1.2 FANTOM5 Ensembl ENCODE 61 -59.3 -59278 1.1 PKNOX1 TBL1XR1 ZNF76 ZNF2 RAD21 ZBTB40 YY1 RFX5 ZNF366 ZNF143 CCL4 CCL3 CCL3L3 CCL5 CCL23 GGNBP2 LOC101927369 ENSG00000282738 LOC100420851
GH17F036055 0.4 FANTOM5 42.1 +34.0 33956 0.5 IRF1 CCL3L3 CCL4 CCL3 CCL5 CCL23 LOC105371746 GC17M036029
GH17F036086 1.6 FANTOM5 Ensembl ENCODE 41.9 +0.1 125 6.3 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 NSD2 YBX1 BMI1 RAD21 ZNF335 CCL3 CCL4 CCL3L3 CCL18 TAF5LP1 SLFN12L CCL5 GGNBP2 ENSG00000277089
GH17F036102 1.3 FANTOM5 Ensembl ENCODE 41 -15.5 -15474 6.9 PKNOX1 ATF1 KLF17 BMI1 SCRT2 CREM EGR2 CEBPB TBX21 ZNF518A CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 ENSG00000270871 PIGW SLFN12L MYO19
GH17F036154 0.4 FANTOM5 37.1 -64.3 -64304 0.4 ZNF316 TBX21 CCL4 CCL3 CCL3L3 CCL4L2 CCL5 CCL23 GGNBP2 ENSG00000282738 LOC100420851 LOC101927369
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL3 Gene

Chromosome:
17
Start:
36,088,256 bp from pter
End:
36,090,169 bp from pter
Size:
1,914 bases
Orientation:
Minus strand

Genomic View for CCL3 Gene

Genes around CCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL3 Gene

Proteins for CCL3 Gene

  • Protein details for CCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10147-CCL3_HUMAN
    Recommended name:
    C-C motif chemokine 3
    Protein Accession:
    P10147

    Protein attributes for CCL3 Gene

    Size:
    92 amino acids
    Molecular mass:
    10085 Da
    Quaternary structure:
    • Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL3 Gene

neXtProt entry for CCL3 Gene

Post-translational modifications for CCL3 Gene

  • N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.

Other Protein References for CCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL3 Gene

Domains & Families for CCL3 Gene

Gene Families for CCL3 Gene

Protein Domains for CCL3 Gene

Suggested Antigen Peptide Sequences for CCL3 Gene

Graphical View of Domain Structure for InterPro Entry

P10147

UniProtKB/Swiss-Prot:

CCL3_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3: view

Function for CCL3 Gene

Molecular function for CCL3 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
UniProtKB/Swiss-Prot Induction:
By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).

Gene Ontology (GO) - Molecular Function for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10734056
GO:0004698 calcium-dependent protein kinase C activity IDA 15764707
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 20959807
GO:0008009 chemokine activity IEA,IDA 10072545
genes like me logo Genes that share ontologies with CCL3: view
genes like me logo Genes that share phenotypes with CCL3: view

Animal Model Products

miRNA for CCL3 Gene

miRTarBase miRNAs that target CCL3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3 Gene

Localization for CCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL3 Gene COMPARTMENTS Subcellular localization image for CCL3 gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 20167378
GO:0005622 intracellular IDA 10072545
GO:0005737 cytoplasm IDA 21784977
GO:0005829 cytosol IDA 19523456
genes like me logo Genes that share ontologies with CCL3: view

Pathways & Interactions for CCL3 Gene

genes like me logo Genes that share pathways with CCL3: view

Gene Ontology (GO) - Biological Process for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001649 osteoblast differentiation IEP 21403648
GO:0001775 cell activation IDA 10706735
GO:0002548 monocyte chemotaxis IDA 10706735
GO:0006816 calcium ion transport IDA 10734056
genes like me logo Genes that share ontologies with CCL3: view

No data available for SIGNOR curated interactions for CCL3 Gene

Drugs & Compounds for CCL3 Gene

(57) Drugs for CCL3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ROX-888 Investigational Pharma Target 0

(50) Additional Compounds for CCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL3: view

Transcripts for CCL3 Gene

mRNA/cDNA for CCL3 Gene

Unigene Clusters for CCL3 Gene

Chemokine (C-C motif) ligand 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3 Gene

No ASD Table

Relevant External Links for CCL3 Gene

GeneLoc Exon Structure for
CCL3
ECgene alternative splicing isoforms for
CCL3

Expression for CCL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL3 Gene

mRNA differential expression in normal tissues according to GTEx for CCL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL3 Gene:

CCL3

SOURCE GeneReport for Unigene cluster for CCL3 Gene:

Hs.514107
genes like me logo Genes that share expression patterns with CCL3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCL3 Gene

Orthologs for CCL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL3 34
  • 98.19 (n)
cow
(Bos Taurus)
Mammalia LOC616364 34
  • 80.95 (n)
dog
(Canis familiaris)
Mammalia LOC480600 34
  • 78.99 (n)
Species where no ortholog for CCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL3 Gene

ENSEMBL:
Gene Tree for CCL3 (if available)
TreeFam:
Gene Tree for CCL3 (if available)

Paralogs for CCL3 Gene

Pseudogenes.org Pseudogenes for CCL3 Gene

genes like me logo Genes that share paralogs with CCL3: view

Variants for CCL3 Gene

Sequence variations from dbSNP and Humsavar for CCL3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1049114 -- 36,088,699(-) AAATA(C/T)GTCAG intron-variant, reference, synonymous-codon
rs1049121 -- 36,088,693(-) GTCAG(C/T)GACCT intron-variant, reference, synonymous-codon
rs1049131 -- 36,088,687(-) GACCT(A/G)GAGCT intron-variant, reference, synonymous-codon
rs1049176 -- 36,088,555(-) TGGTT(A/G)TTGCC intron-variant, utr-variant-3-prime
rs1049188 -- 36,088,485(-) TTTTT(A/G)TAATT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCL3 Gene

Variant ID Type Subtype PubMed ID
dgv120e55 CNV gain 17911159
dgv178n21 CNV loss 19592680
dgv3143n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv522n67 CNV gain 20364138
dgv5534n54 CNV gain 21841781
esv2664544 CNV deletion 23128226
esv2670934 CNV deletion 23128226
esv2762388 CNV gain+loss 21179565
esv33166 CNV gain 17666407
esv3554365 CNV deletion 23714750
esv3640463 CNV gain 21293372
esv3893000 CNV gain+loss 25118596
nsv1059795 CNV gain 25217958
nsv1061066 CNV loss 25217958
nsv1062304 CNV loss 25217958
nsv457733 CNV gain 19166990
nsv471395 CNV gain 19718026
nsv514836 CNV gain 21397061
nsv523265 CNV gain 19592680
nsv574755 CNV gain 21841781
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897
nsv960470 CNV duplication 23825009

Variation tolerance for CCL3 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3 Gene

Disorders for CCL3 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CCL3 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
rheumatoid arthritis
  • rheumatoid arthritis, progression of
pneumonia
  • acute pneumonia
bronchiolitis
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search CCL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL3

Genetic Association Database (GAD)
CCL3
Human Genome Epidemiology (HuGE) Navigator
CCL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL3
genes like me logo Genes that share disorders with CCL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3 Gene

Publications for CCL3 Gene

  1. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PMID: 19055602) Paximadis M. … Tiemessen C.T. (Int. J. Immunogenet. 2009) 3 22 46 64
  2. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PMID: 18242850) Li K. … Wang B. (Neurosci. Lett. 2008) 3 22 46 64
  3. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W. … Kaslow R.A. (Genes Immun. 2007) 3 22 46 64
  4. Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP- 1beta, and RANTES. Characterization of active disaggregated chemokine variants. (PMID: 10347159) Czaplewski L.G. … Hunter M.G. (J. Biol. Chem. 1999) 3 4 22 64
  5. Structures of human genes coding for cytokine LD78 and their expression. (PMID: 1694014) Nakao M. … Shimada K. (Mol. Cell. Biol. 1990) 3 4 22 64

Products for CCL3 Gene

Sources for CCL3 Gene

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