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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL28 Gene

protein-coding   GIFtS: 56
GCID: GC05M043376

chemokine (C-C motif) ligand 28

 Explore 23 diseases affiliated with
CCL28 via our new
 Human Malady Compendium 
Biological research products
for CCL28
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 281 2     C-C Motif Chemokine 282
MEC1 2 3     CC Chemokine CCL282
SCYA281 2 3     Chemokine (C-C Motif) Ligand 28 Splice Variant Chi2
CCK11 2     Small Inducible Cytokine A282
Mucosae-Associated Epithelial Chemokine2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 282
Small-Inducible Cytokine A282 3     Protein CCK13

External Ids:    HGNC: 177001   Entrez Gene: 564772   Ensembl: ENSG000001518827   OMIM: 6052405   UniProtKB: Q9NRJ33   

Export aliases for CCL28 gene to outside databases

Previous GC identifers: GC05M043684 GC05M044553 GC05M043422 GC05M043229 GC05M043332


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL28:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in
immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.
The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The
product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of
extracutaneous epithelial tissues, including diverse mucosal organs. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
calcium mobilization in a dose-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL28 gene promoter:
         STAT1   p53   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL28 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

CCL28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL28 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043376:  view genomic region     (about GC identifiers)

Start:
43,376,747 bp from pter      End:
43,412,493 bp from pter
Size:
35,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3 (See protein sequence)
Recommended Name: C-C motif chemokine 28 precursor  
Size: 127 amino acids; 14280 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CCL28: NX_Q9NRJ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRJ3

  • CCL28 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_683513.1  
    ENSEMBL proteins: 
     ENSP00000426424   ENSP00000354416   ENSP00000422369   ENSP00000443823  
    Reactome Protein details: Q9NRJ3
    Human Recombinant Protein Products: 
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    Novus Biologicals CCL28 Proteins
    Novus Biologicals CCL28 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL28
    Uscn Proteins for CCL28

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--


    CCL28 for ontologies           About GeneDecksing



    CCL28 Antibody Products: 
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    Uscn ELISAs and CLIAs for CCL28


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCL28 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRJ3

    ProtoNet protein and cluster: Q9NRJ3

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
    calcium mobilization in a dose-dependent manner

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL28
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL28:
    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL28 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL28

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CCL28 (NM_148672)
    Sino Biological Human cDNA Clone for CCL28
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL28 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity TAS10781587


    CCL28 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    PEDF Induced Signaling1.00
    STAT3 Pathway0.47
    MIF Mediated Glucocorticoid Regulation0.73
    Endothelin-1 Signaling Pathway0.44
    MIF Regulation of Innate Immune Cells0.71
    NFAT Signaling and Lymphocyte Interactions0.37
    IL-6 Pathway0.61
    PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    TGF-Beta Pathway1.00
    JNK Pathway0.50
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.29
    3Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Peptide ligand-binding receptors0.61
    GPCR ligand binding0.75
    G alpha (i) signalling events0.44
    4Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases1.00
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL28 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    5/8        Reactome Pathways for CCL28 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCL28):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCL28 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for CCL28 (Q9NRJ32, 3 ENSP000003544164) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDI1Q8WTU03I2D: score=1 
    C3ENSP000002459074STRING: ENSP00000245907
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10781587
    GO:0006955immune response IEA--
    GO:0007204elevation of cytosolic calcium ion concentration IEA--


    CCL28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL28 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL28

    1 HMDB Compound for CCL28    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    4 Novoseek chemical compound relationships for CCL28 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 90.1 6 19003934 (2), 16839611 (1)
    devazepide 70.4 1 15104368 (1)
    anthranilate 55.5 2 14987837 (1), 15922840 (1)
    calcium 0 2 10781587 (2)

    Search CenterWatch for drugs/clinical trials and news about CCL28 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL28 gene (2 alternative transcripts): 
    NM_148672.2  NM_019846.3  

    Unigene Cluster for CCL28:

    Chemokine (C-C motif) ligand 28
    Hs.656904  [show with all ESTs]
    Unigene Representative Sequence: AK307307
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489442(uc003jns.3 uc003jnt.3) ENST00000361115(uc003jnu.3 uc021xyh.1)
    ENST00000513525(uc010ivn.3) ENST00000514421 ENST00000537013

    miRNA
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    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL28
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL28

    Additional cDNA sequence: 

    AF220210.1 AF266504.1 AK307307.1 AK312120.1 BC062668.1 BC069532.1 HM067700.1 

    5 DOTS entries:

    DT.100795712  DT.91667792  DT.99983119  DT.40110226  DT.92044042 

    24/35 AceView cDNA sequences (see all 35):

    CB068400 CB984769 CB068281 NM_148672 BQ423222 BF034600 BE463561 AI880389 
    NM_019846 CD671712 AF266504 BG530240 BX108072 BG682175 AW083576 BX486632 
    N63913 BC062668 N98285 N20300 AW469978 AF110384 BE748488 CD685600 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATCATTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CCL28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL28

    SOURCE GeneReport for Unigene cluster: Hs.656904

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological
    colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and
    in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL28: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL28 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl281 , 5 chemokine (C-C motif) ligand 281, 5 75.14(n)1
    65.57(a)1
      135
    568381  NM_020279.31  NP_064675.11 
     1196238195 


    ENSEMBL Gene Tree for CCL28 (if available)
    TreeFam Gene Tree for CCL28 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL28 gene
    CCL272  
    10 SIMAP similar genes for CCL28 using alignment to 4 protein entries:     CCL28_HUMAN (see all proteins):
    IK    KIAA0101    ARL6IP5    GALK2    KIAA1651    SH2B3
    COQ5    CCL27    C1orf143    TUBA1C

    CCL28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/521 NCBI SNPs in CCL28 are shown (see all 521    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424454751,2
    C,--43381175(+) GTTAT-/AAACAC 1 -- ds50010--------
    rs1900017951,2
    --43381181(+) TAACAC/TCAAAA 1 -- ds50010--------
    rs727546011,2
    --43381288(+) AACACA/TTACAA 1 -- ds50010--------
    rs1812839811,2
    --43381343(+) TAATAC/TTGTGG 1 -- ds50010--------
    rs1869032201,2
    --43381377(+) GTACCA/CTTCTT 1 -- ds50010--------
    rs77064021,2
    C,F,A,H,--43381580(+) CCTCAG/ACCTCC 1 -- ds5001 ese38Minor allele frequency- A:0.33NA WA CSA EA 251
    rs68654401,2
    C,F,A,H,--43381738(+) ataaaA/Gggtgt 1 -- ut31 ese310Minor allele frequency- G:0.10NS WA CSA 1458
    rs1408443841,2
    C,F,--43382009(+) ATGTGC/TCCTGT 2 T A mis12Minor allele frequency- T:0.00NA EU 5873
    rs1476113561,2
    C,--43382012(+) TGCCCT/CGTTAC 2 /R /G mis11Minor allele frequency- C:0.00NA 4550
    rs1421988851,2
    C,F,--43382029(+) TCTTGC/ACATGG 2 /G /V mis11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for CCL28 (43376747 - 43412493 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCL28: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL28
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCL28 for disorders           About GeneDecksing

    OMIM gene information: 605240    OMIM disorders: --

    20/23 diseases for CCL28 (see all 23):    About MalaCards
    toxic shock syndrome    adult t-cell leukemia    atopic dermatitis    leukemia/lymphoma
    bronchiolitis    t-cell leukemia    dermatitis    atopy
    hepatitis b    gastritis    leukemia    colon cancer
    psoriasis    colorectal cancer    nephropathy    pancreatitis
    obesity    hepatitis    pneumonia    hypoxia

    4 Novoseek disease relationships for CCL28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 14.5 1 16699265 (1)
    inflammation 0 5 15246961 (1), 16581045 (1), 16785557 (1)
    tumors 0 8 15149184 (1)
    cancer 0 1 16391784 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCL28 (8 documents)

    Export disorders for CCL28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL28 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with CCL28)
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    world of online information

    1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PubMed id 10781587)1, 2, 3, 9 Wang W.... Zlotnik A. (2000)
    2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PubMed id 10975800)1, 2, 9 Pan J.... Soler D. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors. (PubMed id 11295038)1, 3 Mickanin C.S....Labow M. (2001)
    5. Serum mucosa-associated epithelial chemokine (MEC/CCL 28) in atopic dermatitis: a specific marker for severity. (PubMed id 19659860)1, 9 Ezzat M.H....Shaheen K.Y. (2009)
    6. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. (PubMed id 12538707)1, 9 Hieshima K....Yoshie O. (2003)
    7. Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC). (PubMed id 19003934)1, 9 Sundstrom P....Quiding-Jarbrink M. (2008)
    8. IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathway. (PubMed id 16581045)1, 9 O'Gorman M.T....Mahon B.P. (2005)
    9. The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. (PubMed id 17912348)1, 9 Castelletti E....Clerici M. (2007)
    10. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. (PubMed id 16785557)1, 9 Eksteen B....Adams D.H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56477 HGNC: 17700 AceView: CCL28 Ensembl:ENSG00000151882 euGenes: HUgn56477
    ECgene: CCL28 Kegg: 56477 H-InvDB: CCL28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL28 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL28

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL28 gene:
    Search GeneIP for patents involving CCL28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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