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Aliases for CCL28 Gene

Aliases for CCL28 Gene

  • C-C Motif Chemokine Ligand 28 2 3 5
  • Mucosae-Associated Epithelial Chemokine 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28 2 3
  • Small Inducible Cytokine A28 2 3
  • CC Chemokine CCL28 2 3
  • SCYA28 3 4
  • MEC 3 4
  • Chemokine (C-C Motif) Ligand 28 Splice Variant Chi 3
  • Chemokine (C-C Motif) Ligand 28 2
  • Small-Inducible Cytokine A28 4
  • C-C Motif Chemokine 28 3
  • Protein CCK1 4
  • CCK1 3

External Ids for CCL28 Gene

Previous GeneCards Identifiers for CCL28 Gene

  • GC05M043684
  • GC05M044553
  • GC05M043376
  • GC05M043422
  • GC05M043229

Summaries for CCL28 Gene

Entrez Gene Summary for CCL28 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL28 Gene

CCL28 (C-C Motif Chemokine Ligand 28) is a Protein Coding gene. Among its related pathways are Akt Signaling and PEDF Induced Signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.

UniProtKB/Swiss-Prot for CCL28 Gene

  • Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Additional gene information for CCL28 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL28 Gene

Genomics for CCL28 Gene

Regulatory Elements for CCL28 Gene

Enhancers for CCL28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H043482 1.1 ENCODE 12.7 -72.6 -72617 5.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF131 TMEM267 EEF1A1P19 C5orf34 NNT RPL29P12 CCL28 ENSG00000249492 HMGCS1 ENSG00000248240
GH05H043554 1.1 ENCODE 7.7 -144.0 -143984 3.2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 ZC3H11A REST SMARCB1 NNT ENSG00000248240 C5orf34 EEF1A1P19 NNT-AS1 RPL29P12 ENSG00000249492 FGF10-AS1 LOC153684 ENSG00000272382
GH05H043601 1.1 ENCODE 7.3 -190.6 -190638 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 SP3 MXD4 NNT-AS1 NNT TMEM267 ZNF131 CCL28
GH05H042546 0.8 dbSUPER 5.1 +860.1 860053 12.6 FOXA2 JUN MAX RAD21 YY1 GATA3 ZNF316 HNF4G FOS MAFK CCDC152 CCL28 ENSG00000272144 FBXO4 GC05P042548 GC05M042543
GH05H043369 0.4 ENCODE 7.6 +42.1 42073 1.4 ATF2 NNT CCL28 ENSG00000248240 NNT-AS1 ENSG00000188850
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL28 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCL28 Gene

Genomic Locations for CCL28 Gene
chr5:43,356,972-43,412,391
(GRCh38/hg38)
Size:
55,420 bases
Orientation:
Minus strand
chr5:43,376,747-43,412,493
(GRCh37/hg19)

Genomic View for CCL28 Gene

Genes around CCL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL28 Gene

Proteins for CCL28 Gene

  • Protein details for CCL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRJ3-CCL28_HUMAN
    Recommended name:
    C-C motif chemokine 28
    Protein Accession:
    Q9NRJ3
    Secondary Accessions:
    • D7RIE7

    Protein attributes for CCL28 Gene

    Size:
    127 amino acids
    Molecular mass:
    14280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL28 Gene

Post-translational modifications for CCL28 Gene

  • Glycosylation at posLast=7878
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL28 Gene

No data available for DME Specific Peptides for CCL28 Gene

Domains & Families for CCL28 Gene

Gene Families for CCL28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCL28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRJ3

UniProtKB/Swiss-Prot:

CCL28_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL28: view

Function for CCL28 Gene

Molecular function for CCL28 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Phenotypes From GWAS Catalog for CCL28 Gene

Gene Ontology (GO) - Molecular Function for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008009 chemokine activity IEA,TAS 10781587
genes like me logo Genes that share ontologies with CCL28: view
genes like me logo Genes that share phenotypes with CCL28: view

Animal Model Products

miRNA for CCL28 Gene

miRTarBase miRNAs that target CCL28

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL28 Gene

Localization for CCL28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL28 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL28 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CCL28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL28 Gene

Pathways & Interactions for CCL28 Gene

genes like me logo Genes that share pathways with CCL28: view

Gene Ontology (GO) - Biological Process for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IDA 18308860
GO:0006935 chemotaxis TAS 10781587
GO:0006955 immune response IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with CCL28: view

No data available for SIGNOR curated interactions for CCL28 Gene

Drugs & Compounds for CCL28 Gene

(2) Drugs for CCL28 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for CCL28 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL28: view

Transcripts for CCL28 Gene

Unigene Clusters for CCL28 Gene

Chemokine (C-C motif) ligand 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL28 Gene

No ASD Table

Relevant External Links for CCL28 Gene

GeneLoc Exon Structure for
CCL28
ECgene alternative splicing isoforms for
CCL28

Expression for CCL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL28 Gene

mRNA differential expression in normal tissues according to GTEx for CCL28 Gene

This gene is overexpressed in Minor Salivary Gland (x23.7), Breast - Mammary Tissue (x5.6), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for CCL28 Gene

This gene is overexpressed in Milk (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCL28 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCL28 Gene:

CCL28

SOURCE GeneReport for Unigene cluster for CCL28 Gene:

Hs.656904

mRNA Expression by UniProt/SwissProt for CCL28 Gene:

Q9NRJ3-CCL28_HUMAN
Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Evidence on tissue expression from TISSUES for CCL28 Gene

  • Bone(4)
  • Heart(4)
  • Gall bladder(3)
  • Stomach(2.5)
  • Intestine(2.4)
  • Pancreas(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCL28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL28 Gene

Orthologs for CCL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL28 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia CCL28 33 34
  • 87.57 (n)
cow
(Bos Taurus)
Mammalia CCL28 33 34
  • 86.09 (n)
rat
(Rattus norvegicus)
Mammalia Ccl28 33
  • 77.69 (n)
mouse
(Mus musculus)
Mammalia Ccl28 33 16 34
  • 72.5 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
Species where no ortholog for CCL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL28 Gene

ENSEMBL:
Gene Tree for CCL28 (if available)
TreeFam:
Gene Tree for CCL28 (if available)

Paralogs for CCL28 Gene

Paralogs for CCL28 Gene

(1) SIMAP similar genes for CCL28 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL28: view

Variants for CCL28 Gene

Sequence variations from dbSNP and Humsavar for CCL28 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000028138 -- 43,360,048(+) TCCCA(C/T)CTGGC intron-variant
rs1000082254 -- 43,399,961(+) CTGCC(G/T)TAGCT intron-variant
rs1000099907 -- 43,403,766(+) AAAAA(A/T)GATTA intron-variant
rs1000148948 -- 43,412,039(+) AAAAT(C/T)TGTAG intron-variant
rs1000259522 -- 43,405,410(+) ATAAC(A/G)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL28 Gene

Variant ID Type Subtype PubMed ID
nsv508352 CNV deletion 20534489
esv3604901 CNV loss 21293372
esv3604900 CNV gain 21293372
esv3604897 CNV gain 21293372
esv2677437 CNV deletion 23128226

Variation tolerance for CCL28 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL28 Gene

Disorders for CCL28 Gene

Relevant External Links for CCL28

Genetic Association Database (GAD)
CCL28
Human Genome Epidemiology (HuGE) Navigator
CCL28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL28

No disorders were found for CCL28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL28 Gene

Publications for CCL28 Gene

  1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PMID: 10781587) Wang W … Zlotnik A (The Journal of biological chemistry 2000) 2 3 4 22 60
  2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J … Soler D (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 45 60

Products for CCL28 Gene

Sources for CCL28 Gene

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