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CCL28 Gene

protein-coding   GIFtS: 56
GCID: GC05M043376

Chemokine (C-C Motif) Ligand 28

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 281 2     Member 281
Mucosae-Associated Epithelial Chemokine1 2 3     Small Inducible Cytokine Subfamily A (Cys-Cys)1
CC Chemokine CCL281 2     CCK12
Small Inducible Cytokine A281 2     C-C Motif Chemokine 282
Small-Inducible Cytokine A282 3     Chemokine (C-C Motif) Ligand 28 Splice Variant Chi2
MEC2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 282
SCYA282 3     Protein CCK13

External Ids:    HGNC: 177001   Entrez Gene: 564772   Ensembl: ENSG000001518827   OMIM: 6052405   UniProtKB: Q9NRJ33   

Export aliases for CCL28 gene to outside databases

Previous GC identifers: GC05M043684 GC05M044553 GC05M043422 GC05M043229 GC05M043332


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL28 Gene:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins
involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two
adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T
cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may
play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CCL28 Gene:
CCL28 (chemokine (C-C motif) ligand 28) is a protein-coding gene. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.

UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
calcium mobilization in a dose-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL28 gene promoter:
         STAT1   p53   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL28 promoter sequence
   Search Chromatin IP Primers for CCL28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

CCL28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL28 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043376:  view genomic region     (about GC identifiers)

Start:
43,376,747 bp from pter      End:
43,412,493 bp from pter
Size:
35,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3 (See protein sequence)
Recommended Name: C-C motif chemokine 28 precursor  
Size: 127 amino acids; 14280 Da
Secondary accessions: D7RIE7
Alternative splicing: 2 isoforms:  Q9NRJ3-1   Q9NRJ3-2   

Explore the universe of human proteins at neXtProt for CCL28: NX_Q9NRJ3

Explore proteomics data for CCL28 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn78

  • See CCL28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_683513.1  
    ENSEMBL proteins: 
     ENSP00000426424   ENSP00000354416   ENSP00000422369   ENSP00000443823  
    Reactome Protein details: Q9NRJ3

    CCL28 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCL28
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    Novus Biologicals CCL28 Proteins
    Novus Biologicals CCL28 Lysates
    Sino Biological Recombinant Protein for CCL28
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL28
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL28 

     
    antibodies-online proteins for CCL28 (57 products) 

     
    Search antibodies-online for peptides for CCL28

    CCL28 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CCL28
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL28
    antibodies-online antibodies for CCL28 (29 products) 

    CCL28 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL28         (see all)
    GenScript Custom Assay Services for CCL28
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL28 
    antibodies-online kits for CCL28 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRJ3

    ProtoNet protein and cluster: Q9NRJ3

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL28_HUMAN, Q9NRJ3
    Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
    calcium mobilization in a dose-dependent manner

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity TAS10781587
         
    Find genes that share ontologies with CCL28           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL28

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL28:
    hsa-mir-148b-3p (MIRT019466)

    Block miRNA regulation of human, mouse, rat CCL28 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCL28:
    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL28
    Predesigned siRNA for gene silencing in human, mouse, rat CCL28

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL28

    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL28 (NM_148672)
    Sino Biological Human cDNA Clone for CCL28
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL28

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL28
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL28 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL28_HUMAN, Q9NRJ3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with CCL28           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL28 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with CCL28           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL28
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL28 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    2 Reactome Pathways for CCL28
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCL28):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL28: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL28 (Q9NRJ32, 3 ENSP000003544164) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDI1Q8WTU03I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    C3ENSP000002459074STRING: ENSP00000245907
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10781587
    GO:0006955immune response IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007584response to nutrient IEA--
    GO:0060326cell chemotaxis TAS10781587

    Find genes that share ontologies with CCL28           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL28

    1 HMDB Compound for CCL28    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for CCL28 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 90.1 6 19003934 (2), 16839611 (1)
    devazepide 70.4 1 15104368 (1)
    anthranilate 55.5 2 14987837 (1), 15922840 (1)
    calcium 0 2 10781587 (2)



    Find genes that share compounds with CCL28           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL28 gene (2 alternative transcripts): 
    NM_148672.2  NM_019846.3  

    Unigene Cluster for CCL28:

    Chemokine (C-C motif) ligand 28
    Hs.656904  [show with all ESTs]
    Unigene Representative Sequence: AK307307
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489442(uc003jns.3 uc003jnt.3) ENST00000361115(uc003jnu.3 uc021xyh.1)
    ENST00000513525(uc010ivn.3) ENST00000514421 ENST00000537013
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL28 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCL28:
    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCL28
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    Primer
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    OriGene qPCR primer pairs and template standards for CCL28
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL28
      QuantiTect SYBR Green Assays in human, mouse, rat CCL28
      QuantiFast Probe-based Assays in human, mouse, rat CCL28

    Additional mRNA sequence: 

    AF220210.1 AF266504.1 AK307307.1 AK312120.1 BC062668.1 BC069532.1 HM067700.1 

    5 DOTS entries:

    DT.100795712  DT.91667792  DT.99983119  DT.40110226  DT.92044042 

    Selected AceView cDNA sequences (see all 35):

    CD671712 CB068400 NM_148672 AI880389 BF034600 CB068281 CB984769 BE463561 
    AF266504 BQ423222 NM_019846 BX486632 N98285 BC062668 BG682175 AW083576 
    N20300 N63913 AW469978 BG530240 AF110384 BX108072 BE748488 BE748785 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCATTAA
    CCL28 Expression
    About this image

    CCL28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656904

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and
    pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid,
    psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and
    normal skin

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL28: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL28
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL28
    QuantiTect SYBR Green Assays in human, mouse, rat CCL28
    QuantiFast Probe-based Assays in human, mouse, rat CCL28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL28 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl281 , 5 chemokine (C-C motif) ligand 281, 5 72.5(n)1
    67.5(a)1
      135
    568381  NM_020279.31  NP_064675.11 
     1196238195 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    1 → many
    2(6107171-6118573)


    ENSEMBL Gene Tree for CCL28 (if available)
    TreeFam Gene Tree for CCL28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL28 gene
    CCL272  
    1 SIMAP similar gene for CCL28 using alignment to 3 protein entries:     CCL28_HUMAN (see all proteins):
    CCL27

    Find genes that share paralogs with CCL28           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL28 (see all 617)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424454751,2
    C--43381176(+) GTTAT-/AAACAC 1 -- ds50010--------
    rs1900017951,2
    --43381181(+) TAACAC/TCAAAA 1 -- ds50010--------
    rs727546011,2
    --43381288(+) AACACA/TTACAA 1 -- ds50010--------
    rs1812839811,2
    --43381343(+) TAATAC/TTGTGG 1 -- ds50010--------
    rs1869032201,2
    --43381377(+) GTACCA/CTTCTT 1 -- ds50010--------
    rs77064021,2
    C,F,A,H--43381580(+) cctcaG/Acctcc 1 -- ds5001 ese38Minor allele frequency- A:0.33NA WA CSA EA 251
    rs68654401,2
    C,F,A,H--43381738(+) ataaaA/Gggtgt 1 -- ut31 ese310Minor allele frequency- G:0.10NS WA CSA 1458
    rs1408443841,2
    C,F--43382009(+) ATGTGC/TCCTGT 2 T A mis12Minor allele frequency- T:0.00NA EU 5873
    rs1476113561,2
    C--43382012(+) TGCCCT/CGTTAC 2 /R /G mis11Minor allele frequency- C:0.00NA 4550
    rs1421988851,2
    C,F--43382029(+) TCTTGC/ACATGG 2 /G /V mis11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for CCL28 (43376747 - 43412493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677437CNV Deletion23128226
    nsv508352CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL28
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605240    OMIM disorders: --


    Find genes that share disorders with CCL28           About GenesLikeMe

    4 Novoseek inferred disease relationships for CCL28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 14.5 1 16699265 (1)
    inflammation 0 5 15246961 (1), 16581045 (1), 16785557 (1)
    tumors 0 8 15149184 (1)
    cancer 0 1 16391784 (1)

    Genetic Association Database (GAD): CCL28
    Human Genome Epidemiology (HuGE) Navigator: CCL28 (8 documents)

    Export disorders for CCL28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL28 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with CCL28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PubMed id 10781587)1, 2, 3, 9 Wang W.... Zlotnik A. (J. Biol. Chem. 2000)
    2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PubMed id 10975800)1, 2, 9 Pan J.... Soler D. (J. Immunol. 2000)
    3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors. (PubMed id 11295038)1, 3 Mickanin C.S....Labow M. (Int. J. Oncol. 2001)
    9. Serum mucosa-associated epithelial chemokine (MEC/CCL28) in atopic dermatitis: a specific marker for severity. (PubMed id 19659860)1, 9 Ezzat M.H....Shaheen K.Y. (Int. J. Dermatol. 2009)
    10. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. (PubMed id 12538707)1, 9 Hieshima K....Yoshie O. (J. Immunol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56477 HGNC: 17700 AceView: CCL28 Ensembl:ENSG00000151882 euGenes: HUgn56477
    ECgene: CCL28 Kegg: 56477 H-InvDB: CCL28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL28 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL28

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL28 gene:
    Search GeneIP for patents involving CCL28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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