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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL28 Gene

protein-coding   GIFtS: 56
GCID: GC05M043376

Chemokine (C-C Motif) Ligand 28

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 281 2     Member 281
Mucosae-Associated Epithelial Chemokine1 2 3     Small Inducible Cytokine Subfamily A (Cys-Cys)1
CC Chemokine CCL281 2     CCK12
Small Inducible Cytokine A281 2     C-C Motif Chemokine 282
Small-Inducible Cytokine A282 3     Chemokine (C-C Motif) Ligand 28 Splice Variant Chi2
MEC2 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 282
SCYA282 3     Protein CCK13

External Ids:    HGNC: 177001   Entrez Gene: 564772   Ensembl: ENSG000001518827   OMIM: 6052405   UniProtKB: Q9NRJ33   

Export aliases for CCL28 gene to outside databases

Previous GC identifers: GC05M043684 GC05M044553 GC05M043422 GC05M043229 GC05M043332


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL28 Gene:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins
involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two
adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T
cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may
play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CCL28 Gene: 
CCL28 (chemokine (C-C motif) ligand 28) is a protein-coding gene. Diseases associated with CCL28 include toxic shock syndrome, and adult t-cell leukemia, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.

UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
calcium mobilization in a dose-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL28 gene promoter:
         STAT1   p53   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL28 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

CCL28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL28 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043376:  view genomic region     (about GC identifiers)

Start:
43,376,747 bp from pter      End:
43,412,493 bp from pter
Size:
35,747 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3 (See protein sequence)
Recommended Name: C-C motif chemokine 28 precursor  
Size: 127 amino acids; 14280 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CCL28: NX_Q9NRJ3

Explore proteomics data for CCL28 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRJ3

  • CCL28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL28 Protein Expression
    REFSEQ proteins: NP_683513.1  
    ENSEMBL proteins: 
     ENSP00000426424   ENSP00000354416   ENSP00000422369   ENSP00000443823  
    Reactome Protein details: Q9NRJ3
    Human Recombinant Protein Products for CCL28: 
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    OriGene Protein Over-expression Lysate for CCL28
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    GenScript Purified and Recombinant Proteins for CCL28
    Novus Biologicals CCL28 Proteins
    Novus Biologicals CCL28 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL28
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL28 for ontologies           About GeneDecksing



    CCL28 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRJ3

    ProtoNet protein and cluster: Q9NRJ3

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL28_HUMAN, Q9NRJ3
    Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces
    calcium mobilization in a dose-dependent manner

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity TAS10781587
         
    CCL28 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL28 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL28 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL28 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL28:
    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL28
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL28 (NM_148672)
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                         Customized lentivirus expression plasmids for stable overexpression of CCL28 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL28 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL28 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    5/8        Reactome Pathways for CCL28 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCL28):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCL28 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for CCL28 (Q9NRJ32, 3 ENSP000003544164) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDI1Q8WTU03I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    C3ENSP000002459074STRING: ENSP00000245907
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10781587
    GO:0006955immune response IEA--
    GO:0007204elevation of cytosolic calcium ion concentration IEA--

    CCL28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL28 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL28

    1 HMDB Compound for CCL28    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for CCL28 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 90.1 6 19003934 (2), 16839611 (1)
    devazepide 70.4 1 15104368 (1)
    anthranilate 55.5 2 14987837 (1), 15922840 (1)
    calcium 0 2 10781587 (2)

    Search CenterWatch for drugs/clinical trials and news about CCL28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL28 gene (2 alternative transcripts): 
    NM_148672.2  NM_019846.3  

    Unigene Cluster for CCL28:

    Chemokine (C-C motif) ligand 28
    Hs.656904  [show with all ESTs]
    Unigene Representative Sequence: AK307307
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489442(uc003jns.3 uc003jnt.3) ENST00000361115(uc003jnu.3 uc021xyh.1)
    ENST00000513525(uc010ivn.3) ENST00000514421 ENST00000537013
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL28:
    hsa-miR-579 hsa-miR-2052 hsa-miR-3926 hsa-miR-19b-2* hsa-miR-19b-1* hsa-miR-19a* hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCL28 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL28 (NM_148672)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL28
    Sirion Biotech Customized lentivirus for stable overexpression of CCL28 
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL28
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL28
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL28

    Additional mRNA sequence: 

    AF220210.1 AF266504.1 AK307307.1 AK312120.1 BC062668.1 BC069532.1 HM067700.1 

    5 DOTS entries:

    DT.100795712  DT.91667792  DT.99983119  DT.40110226  DT.92044042 

    24/35 AceView cDNA sequences (see all 35):

    CB068400 BF034600 CD671712 BQ423222 CB984769 CB068281 NM_148672 AI880389 
    NM_019846 AF266504 BE463561 N20300 BC062668 AF110384 BX486632 BX108072 
    BG530240 BG682175 AW083576 N98285 AW469978 N63913 CB177303 BG532385 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCATTAA
    CCL28 Expression
    About this image


    See CCL28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL28

    SOURCE GeneReport for Unigene cluster: Hs.656904

    UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3
    Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and
    pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid,
    psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and
    normal skin

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL28: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL28 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl281 , 5 chemokine (C-C motif) ligand 281, 5 75.14(n)1
    65.57(a)1
      135
    568381  NM_020279.31  NP_064675.11 
     1196238195 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    34(a)
    1 → many
    2(6107171-6118573)


    ENSEMBL Gene Tree for CCL28 (if available)
    TreeFam Gene Tree for CCL28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL28 gene
    CCL272  
    11 SIMAP similar genes for CCL28 using alignment to 4 protein entries:     CCL28_HUMAN (see all proteins):
    IK    KIAA0101    ARL6IP5    GALK2    KIAA1651    ZNF28
    SH2B3    COQ5    CCL27    C1orf143    TUBA1C

    CCL28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/617 SNPs in CCL28 are shown (see all 617)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424454751,2
    C--43381176(+) GTTAT-/AAACAC 1 -- ds50010--------
    rs1900017951,2
    --43381181(+) TAACAC/TCAAAA 1 -- ds50010--------
    rs727546011,2
    --43381288(+) AACACA/TTACAA 1 -- ds50010--------
    rs1812839811,2
    --43381343(+) TAATAC/TTGTGG 1 -- ds50010--------
    rs1869032201,2
    --43381377(+) GTACCA/CTTCTT 1 -- ds50010--------
    rs77064021,2
    C,F,A,H--43381580(+) cctcaG/Acctcc 1 -- ds5001 ese38Minor allele frequency- A:0.33NA WA CSA EA 251
    rs68654401,2
    C,F,A,H--43381738(+) ataaaA/Gggtgt 1 -- ut31 ese310Minor allele frequency- G:0.10NS WA CSA 1458
    rs1408443841,2
    C,F--43382009(+) ATGTGC/TCCTGT 2 T A mis12Minor allele frequency- T:0.00NA EU 5873
    rs1476113561,2
    C--43382012(+) TGCCCT/CGTTAC 2 /R /G mis11Minor allele frequency- C:0.00NA 4550
    rs1421988851,2
    C,F--43382029(+) TCTTGC/ACATGG 2 /G /V mis11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for CCL28 (43376747 - 43412493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL28:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677437CNV Deletion23128226
    nsv508352CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL28
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605240    OMIM disorders: --

    20 diseases for CCL28:    About MalaCards
    toxic shock syndrome    adult t-cell leukemia    atopy    bronchiolitis
    gastritis    atopic dermatitis    t-cell leukemia    dermatitis
    psoriasis    hypoxia    obesity    hepatitis b
    colon cancer    pancreatitis    colorectal cancer    leukemia
    thyroiditis    hepatitis    prostatitis    neuronitis


    CCL28 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CCL28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 14.5 1 16699265 (1)
    inflammation 0 5 15246961 (1), 16581045 (1), 16785557 (1)
    tumors 0 8 15149184 (1)
    cancer 0 1 16391784 (1)

    Genetic Association Database (GAD): CCL28
    Human Genome Epidemiology (HuGE) Navigator: CCL28 (8 documents)

    Export disorders for CCL28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL28 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with CCL28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PubMed id 10781587)1, 2, 3, 9 Wang W.... Zlotnik A. (2000)
    2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PubMed id 10975800)1, 2, 9 Pan J.... Soler D. (2000)
    3. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors. (PubMed id 11295038)1, 3 Mickanin C.S....Labow M. (2001)
    9. Serum mucosa-associated epithelial chemokine (MEC/CCL 28) in atopic dermatitis: a specific marker for severity. (PubMed id 19659860)1, 9 Ezzat M.H....Shaheen K.Y. (2009)
    10. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. (PubMed id 12538707)1, 9 Hieshima K....Yoshie O. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56477 HGNC: 17700 AceView: CCL28 Ensembl:ENSG00000151882 euGenes: HUgn56477
    ECgene: CCL28 Kegg: 56477 H-InvDB: CCL28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL28 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL28

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL28 gene:
    Search GeneIP for patents involving CCL28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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