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Aliases for CCL28 Gene

Aliases for CCL28 Gene

  • Chemokine (C-C Motif) Ligand 28 2 3
  • Mucosae-Associated Epithelial Chemokine 2 3 4
  • Small Inducible Cytokine A28 2 3
  • Small-Inducible Cytokine A28 3 4
  • CC Chemokine CCL28 2 3
  • SCYA28 3 4
  • MEC 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28 3
  • Chemokine (C-C Motif) Ligand 28 Splice Variant Chi 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys) 2
  • C-C Motif Chemokine 28 3
  • Protein CCK1 4
  • Member 28 2
  • CCK1 3

External Ids for CCL28 Gene

Summaries for CCL28 Gene

Entrez Gene Summary for CCL28 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL28 Gene

CCL28 (Chemokine (C-C Motif) Ligand 28) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.

UniProtKB/Swiss-Prot for CCL28 Gene

  • Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL28 Gene

Genomics for CCL28 Gene

Genomic Location for CCL28 Gene

Start:
43,357,484 bp from pter
End:
43,412,391 bp from pter
Size:
54,908 bases
Orientation:
Minus strand

Genomic View for CCL28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL28 Gene

Regulatory Elements for CCL28 Gene

Proteins for CCL28 Gene

  • Protein details for CCL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRJ3-CCL28_HUMAN
    Recommended name:
    C-C motif chemokine 28
    Protein Accession:
    Q9NRJ3
    Secondary Accessions:
    • D7RIE7

    Protein attributes for CCL28 Gene

    Size:
    127 amino acids
    Molecular mass:
    14280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL28 Gene

Proteomics data for CCL28 Gene at MOPED

Post-translational modifications for CCL28 Gene

Other Protein References for CCL28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL28 Gene

Domains for CCL28 Gene

Gene Families for CCL28 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL28 Gene

UniProtKB/Swiss-Prot:

CCL28_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • Q9NRJ3
genes like me logo Genes that share domains with CCL28: view

Function for CCL28 Gene

Molecular function for CCL28 Gene

UniProtKB/Swiss-Prot Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner

Gene Ontology (GO) - Molecular Function for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008009 chemokine activity TAS 10781587
genes like me logo Genes that share ontologies with CCL28: view

miRNA for CCL28 Gene

miRTarBase miRNAs that target CCL28

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL28 Gene

Localization for CCL28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL28 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL28 Gene COMPARTMENTS Subcellular localization image for CCL28 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CCL28: view

Pathways for CCL28 Gene

genes like me logo Genes that share pathways with CCL28: view

Gene Ontology (GO) - Biological Process for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IDA 18308860
GO:0006935 chemotaxis TAS 10781587
GO:0006955 immune response IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with CCL28: view

Compounds for CCL28 Gene

(1) HMDB Compounds for CCL28 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for CCL28 Gene

Compound -log(P) Hits PubMed IDs
teck 90.1 3
devazepide 70.4 1
anthranilate 55.5 2
calcium 0 2
genes like me logo Genes that share compounds with CCL28: view

Transcripts for CCL28 Gene

Unigene Clusters for CCL28 Gene

Chemokine (C-C motif) ligand 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL28 Gene

No ASD Table

Relevant External Links for CCL28 Gene

GeneLoc Exon Structure for
CCL28
ECgene alternative splicing isoforms for
CCL28

Expression for CCL28 Gene

mRNA expression in normal human tissues for CCL28 Gene

mRNA differential expression in normal tissues according to GTEx for CCL28 Gene

This gene is overexpressed in Minor Salivary Gland (23.7), Breast - Mammary Tissue (5.6), and Colon - Transverse (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCL28 Gene

SOURCE GeneReport for Unigene cluster for CCL28 Gene Hs.656904

mRNA Expression by UniProt/SwissProt for CCL28 Gene

Q9NRJ3-CCL28_HUMAN
Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin
genes like me logo Genes that share expressions with CCL28: view

Orthologs for CCL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL28 36
  • 100 (n)
  • 100 (a)
CCL28 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL28 36
  • 86.09 (n)
  • 77.95 (a)
CCL28 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL28 36
  • 87.57 (n)
  • 80.16 (a)
CCL28 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl28 36
  • 72.5 (n)
  • 67.5 (a)
Ccl28 16
Ccl28 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl28 36
  • 77.69 (n)
  • 72.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 34 (a)
OneToMany
Species with no ortholog for CCL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL28 Gene

ENSEMBL:
Gene Tree for CCL28 (if available)
TreeFam:
Gene Tree for CCL28 (if available)

Paralogs for CCL28 Gene

Paralogs for CCL28 Gene

Selected SIMAP similar genes for CCL28 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL28: view

Variants for CCL28 Gene

Sequence variations from dbSNP and Humsavar for CCL28 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs754527 -- 43,402,335(+) ggacc(C/T)tgaTT intron-variant
rs779850 -- 43,383,296(+) ATATA(C/T)AGTAT intron-variant
rs779851 -- 43,407,741(+) atcta(C/T)ccatc intron-variant
rs779852 -- 43,407,951(+) tctca(C/T)accag intron-variant
rs779853 -- 43,407,974(+) tcatt(A/C)aaaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL28 Gene

Variant ID Type Subtype PubMed ID
nsv508352 CNV Loss 20534489
esv2677437 CNV Deletion 23128226

Relevant External Links for CCL28 Gene

HapMap Linkage Disequilibrium report
CCL28

Disorders for CCL28 Gene

(4) Novoseek inferred disease relationships for CCL28 Gene

Disease -log(P) Hits PubMed IDs
pancreatitis 14.5 1
inflammation 0 3
tumors 0 1
cancer 0 1

Relevant External Links for CCL28

Genetic Association Database (GAD)
CCL28
Human Genome Epidemiology (HuGE) Navigator
CCL28
genes like me logo Genes that share disorders with CCL28: view

No data available for UniProtKB/Swiss-Prot for CCL28 Gene

Publications for CCL28 Gene

  1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PMID: 10781587) Wang W. … Zlotnik A. (J. Biol. Chem. 2000) 2 3 4 23
  2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J. … Soler D. (J. Immunol. 2000) 3 4 23
  3. The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. (PMID: 17912348) Castelletti E. … Clerici M. (PLoS ONE 2007) 3 23
  4. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. (PMID: 16785557) Eksteen B. … Adams D.H. (J. Immunol. 2006) 3 23
  5. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. (PMID: 12538707) Hieshima K. … Yoshie O. (J. Immunol. 2003) 3 23

Products for CCL28 Gene

Sources for CCL28 Gene

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