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Aliases for CCL27 Gene

Aliases for CCL27 Gene

  • Chemokine (C-C Motif) Ligand 27 2 3
  • CC Chemokine ILC 2 3 4
  • SCYA27 3 4 6
  • CTACK 3 4 6
  • ILC 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27 2 3
  • Cutaneous T-Cell Attracting Chemokine 2 3
  • Cutaneous T-Cell-Attracting Chemokine 3 4
  • IL-11 R-Alpha-Locus Chemokine 3 4
  • IL-11 Ralpha-Locus Chemokine 2 3
  • Small-Inducible Cytokine A27 3 4
  • Skinkine 3 4
  • ESKINE 3 4
  • C-C Motif Chemokine 27 3
  • PESKY 3
  • CCL27 6
  • CTAK 3
  • ALP 3

External Ids for CCL27 Gene

Previous HGNC Symbols for CCL27 Gene

  • SCYA27

Previous GeneCards Identifiers for CCL27 Gene

  • GC09M034974
  • GC09M034831
  • GC09M034651
  • GC09M034616

Summaries for CCL27 Gene

Entrez Gene Summary for CCL27 Gene

  • This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL27 Gene

CCL27 (Chemokine (C-C Motif) Ligand 27) is a Protein Coding gene. Diseases associated with CCL27 include chronic recurrent multifocal osteomyelitis and hypophosphatasia. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL28.

UniProtKB/Swiss-Prot for CCL27 Gene

  • Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL27 Gene

Genomics for CCL27 Gene

Regulatory Elements for CCL27 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCL27 Gene

Start:
34,661,880 bp from pter
End:
34,664,048 bp from pter
Size:
2,169 bases
Orientation:
Minus strand

Genomic View for CCL27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL27 Gene

Proteins for CCL27 Gene

  • Protein details for CCL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X3-CCL27_HUMAN
    Recommended name:
    C-C motif chemokine 27
    Protein Accession:
    Q9Y4X3
    Secondary Accessions:

    Protein attributes for CCL27 Gene

    Size:
    112 amino acids
    Molecular mass:
    12618 Da
    Quaternary structure:
    • Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

    Three dimensional structures from OCA and Proteopedia for CCL27 Gene

neXtProt entry for CCL27 Gene

Proteomics data for CCL27 Gene at MOPED

Post-translational modifications for CCL27 Gene

No Post-translational modifications

Other Protein References for CCL27 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL27 Gene

Domains for CCL27 Gene

Gene Families for CCL27 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL27 Gene

Suggested Antigen Peptide Sequences for CCL27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4X3

UniProtKB/Swiss-Prot:

CCL27_HUMAN :
  • Q9Y4X3
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL27: view

Function for CCL27 Gene

Molecular function for CCL27 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10

Gene Ontology (GO) - Molecular Function for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL27: view

Animal Model Products

CRISPR Products

miRNA for CCL27 Gene

miRTarBase miRNAs that target CCL27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL27 Gene

Localization for CCL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL27 Gene COMPARTMENTS Subcellular localization image for CCL27 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL27: view

Pathways for CCL27 Gene

genes like me logo Genes that share pathways with CCL27: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10588729
GO:0006955 immune response IEA --
GO:0007267 cell-cell signaling TAS 10588729
GO:0060326 cell chemotaxis TAS 10588729
genes like me logo Genes that share ontologies with CCL27: view

Compounds for CCL27 Gene

(15) Novoseek inferred chemical compound relationships for CCL27 Gene

Compound -log(P) Hits PubMed IDs
tarc 86.3 37
ccl3 50.4 2
deoxypyridinoline 46.6 2
ccl4 44.2 5
rantes 25.3 2
genes like me logo Genes that share compounds with CCL27: view

Transcripts for CCL27 Gene

mRNA/cDNA for CCL27 Gene

(62) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL27 Gene

Chemokine (C-C motif) ligand 27:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL27

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCL27
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL27 Gene

No ASD Table

Relevant External Links for CCL27 Gene

GeneLoc Exon Structure for
CCL27
ECgene alternative splicing isoforms for
CCL27

Expression for CCL27 Gene

mRNA expression in normal human tissues for CCL27 Gene

mRNA differential expression in normal tissues according to GTEx for CCL27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (22.2) and Skin - Sun Exposed (Lower leg) (16.2).

SOURCE GeneReport for Unigene cluster for CCL27 Gene Hs.648124

mRNA Expression by UniProt/SwissProt for CCL27 Gene

Q9Y4X3-CCL27_HUMAN
Tissue specificity: Testis, thymus, placenta, ovary and skin
genes like me logo Genes that share expressions with CCL27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CCL27 Gene

Orthologs for CCL27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL27 35
  • 99.7 (n)
  • 100 (a)
CCL27 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL27 35
  • 84.44 (n)
  • 67.78 (a)
CCL27 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL27 35
  • 83.18 (n)
  • 73.87 (a)
CTACK 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia CCL27 36
  • 42 (a)
OneToMany
CCL27 36
  • 44 (a)
OneToMany
Ccl27a 16
Ccl27a 36
  • 35 (a)
OneToMany
Ccl27b 36
  • 57 (a)
OneToMany
Gm13306 36
  • 42 (a)
OneToMany
LOC100861978 35
  • 77.42 (n)
  • 62.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CCL27 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
OneToMany
Species with no ortholog for CCL27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL27 Gene

ENSEMBL:
Gene Tree for CCL27 (if available)
TreeFam:
Gene Tree for CCL27 (if available)

Paralogs for CCL27 Gene

Paralogs for CCL27 Gene

Selected SIMAP similar genes for CCL27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL27: view

Variants for CCL27 Gene

Sequence variations from dbSNP and Humsavar for CCL27 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2812365 -- 34,663,141(+) TCTGA(C/T)AGGGG upstream-variant-2KB
rs3818630 -- 34,662,886(+) ACTGA(C/T)GGAAC upstream-variant-2KB
rs7865786 -- 34,663,121(+) TCACA(C/T)TAGCA upstream-variant-2KB
rs11575595 -- 34,662,434(+) GGGCC(A/G)TGTGT intron-variant
rs11575596 -- 34,662,453(+) ATCCT(A/G)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL27 Gene

Variant ID Type Subtype PubMed ID
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354
nsv831544 CNV Gain 17160897

Relevant External Links for CCL27 Gene

HapMap Linkage Disequilibrium report
CCL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL27 Gene

Disorders for CCL27 Gene

(22) Novoseek inferred disease relationships for CCL27 Gene

Disease -log(P) Hits PubMed IDs
dermatitis atopic 68.2 17
liver dysfunction 50.5 3
skin diseases 46.4 3
psoriasis 42.3 4
necrosis 39.9 11

Relevant External Links for CCL27

Genetic Association Database (GAD)
CCL27
Human Genome Epidemiology (HuGE) Navigator
CCL27
genes like me logo Genes that share disorders with CCL27: view

No data available for UniProtKB/Swiss-Prot for CCL27 Gene

Publications for CCL27 Gene

  1. CTACK, a skin-associated chemokine that preferentially attracts skin- homing memory T cells. (PMID: 10588729) Morales J. … Zlotnik A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B. … Zlotnik A. (J. Immunol. 2000) 3 4 23
  3. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. (PMID: 10556532) Ishikawa-Mochizuki I. … Yoshie O. (FEBS Lett. 1999) 2 3 4
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PMID: 17703412) Janssen R. … Hoebee B. (J. Infect. Dis. 2007) 3 48
  5. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48

Products for CCL27 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL27
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL27
    • Block miRNA regulation of CCL27 using miScript Target Protectors
    • Addgene plasmids for CCL27

    Sources for CCL27 Gene

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