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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL27 Gene

protein-coding   GIFtS: 55
GCID: GC09M034662

Chemokine (C-C Motif) Ligand 27

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 27)
(Previous symbol: SCYA27)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 271 2     IL-11 R-Alpha-Locus Chemokine2 3
SCYA271 2 3 5     ALP2
CC Chemokine ILC1 2 3     CTAK2
CTACK2 3 5     ESKINE2
ILC2 3 5     PESKY2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 271 2     C-C Motif Chemokine 272
Cutaneous T-Cell Attracting Chemokine1 2     skinkine2
IL-11 Ralpha-Locus Chemokine1 2     ESkine3
Cutaneous T-Cell-Attracting Chemokine2 3     Skinkine3
Small-Inducible Cytokine A272 3     

External Ids:    HGNC: 106261   Entrez Gene: 108502   Ensembl: ENSG000002139277   OMIM: 6048335   UniProtKB: Q9Y4X33   

Export aliases for CCL27 gene to outside databases

Previous GC identifers: GC09M034974 GC09M034831 GC09M034651 GC09M034616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL27 Gene:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated
memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites.
It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these
protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. (provided by RefSeq, Jul
2008)

GeneCards Summary for CCL27 Gene: 
CCL27 (chemokine (C-C motif) ligand 27) is a protein-coding gene. Diseases associated with CCL27 include chronic recurrent multifocal osteomyelitis, and exanthem, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL28.

UniProtKB/Swiss-Prot: CCL27_HUMAN, Q9Y4X3
Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating
homing of lymphocytes to cutaneous sites. Binds to CCR10




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL27 gene promoter:
         p53   ATF-2   c-Jun   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL27 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

CCL27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL27 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034662:  view genomic region     (about GC identifiers)

Start:
34,661,877 bp from pter      End:
34,664,045 bp from pter
Size:
2,169 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL27_HUMAN, Q9Y4X3 (See protein sequence)
Recommended Name: C-C motif chemokine 27 precursor  
Size: 112 amino acids; 12618 Da
Subunit: Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CCL27:
2KUM (3D)    

Explore the universe of human proteins at neXtProt for CCL27: NX_Q9Y4X3

Explore proteomics data for CCL27 at MOPED 

CCL27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CCL27 Protein Expression

REFSEQ proteins: NP_006655.1  
ENSEMBL proteins: 
 ENSP00000259631  
Reactome Protein details: Q9Y4X3
Human Recombinant Protein Products for CCL27: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL27 (CCL27/CTACK)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CCL27
OriGene Custom MassSpec 
OriGene Custom Protein Services for CCL27
GenScript Custom Purified and Recombinant Proteins Services for CCL27
Novus Biologicals CCL27 Proteins
Novus Biologicals CCL27 Lysates
Sino Biological Recombinant Protein for CCL27
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for CCL27
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

CCL27 for ontologies           About GeneDecksing



CCL27 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL27 (CCL27/CTACK)
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OriGene Custom Antibody Services for CCL27
GenScript Custom Superior Antibodies Services for CCL27
Novus Biologicals CCL27 Antibodies
Abcam antibodies for CCL27
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibodies for CCL27
LSBio Antibodies in human, mouse, rat for CCL27 

Assay Products for CCL27: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL27
R&D Systems ELISAs for CCL27 (CCL27/CTACK)
GenScript Custom Assay Services for CCL27
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands
CCL: Chemokine ligands

1 InterPro protein domain:
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q9Y4X3

ProtoNet protein and cluster: Q9Y4X3

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL27_HUMAN, Q9Y4X3
Similarity: Belongs to the intercrine beta (chemokine CC) family


CCL27 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL27_HUMAN, Q9Y4X3
Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating
homing of lymphocytes to cutaneous sites. Binds to CCR10

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IEA--
     
CCL27 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL27 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL27

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL27 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL27 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL27
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL27
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for CCL27
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL27

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL27
Sirion Biotech Customized adenovirus for overexpression of CCL27

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CCL27 (see all 5)
OriGene ORF clones in mouse, rat for CCL27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL27 (NM_006664)
Sino Biological Human cDNA Clone for CCL27
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL27
Sirion Biotech Customized lentivirus for stable overexpression of CCL27 
                     Customized lentivirus expression plasmids for stable overexpression of CCL27 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCL27
Search LifeMap BioReagents cell lines for CCL27
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL27


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CCL27 About   (see all 10)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
3TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
4Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.46
5Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL27 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway


5/8        Reactome Pathways for CCL27 (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
Signal Transduction
Signaling by GPCR


2         Kegg Pathways  (Kegg details for CCL27):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway


CCL27 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL27

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/152 Interacting proteins for CCL27 (Q9Y4X33 ENSP000002596314) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
InteractantInteraction Details
GeneCardExternal ID(s)
CCR10P460923, ENSP000003325044I2D: score=2 STRING: ENSP00000332504
ACKR2O005903, ENSP000002731454I2D: score=1 STRING: ENSP00000273145
ACKR3ENSP000002729284STRING: ENSP00000272928
APLNRENSP000002572544STRING: ENSP00000257254
CCL16ENSP000002932754STRING: ENSP00000293275
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis TAS10588729
GO:0006955immune response IEA--
GO:0007267cell-cell signaling TAS10588729

CCL27 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL27 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL27

10/15 Novoseek inferred chemical compound relationships for CCL27 gene (see all 15)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 86.3 45 14767451 (8), 16499646 (8), 15335355 (7), 18173519 (3) (see all 11)
ccl3 50.4 2 17369706 (1), 19450895 (1)
deoxypyridinoline 46.6 2 16912030 (1), 17013436 (1)
ccl4 44.2 5 17369706 (1), 18250572 (1), 19054079 (1), 19450895 (1) (see all 5)
rantes 25.3 2 19765644 (1), 16891627 (1)
hydroxyapatite 22.2 2 10817261 (1), 19646460 (1)
alanine 20 6 8988805 (1), 15235890 (1), 19920397 (1), 11127322 (1) (see all 6)
calcium 18.8 9 8156283 (1), 10725697 (1), 15355401 (1), 18431785 (1) (see all 8)
aspartate 16.4 4 15235890 (1), 19920397 (1), 7618165 (1), 16549178 (1)
allergens 7.39 1 15813678 (1)

Search CenterWatch for drugs/clinical trials and news about CCL27

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL27 gene: 
NM_006664.2  

Unigene Cluster for CCL27:

Chemokine (C-C motif) ligand 27
Hs.648124  [show with all ESTs]
Unigene Representative Sequence: BX454404
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000557161 ENST00000259631(uc003zvm.1)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL27
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL27
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CCL27
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL27
Clone
Products:
     
OriGene clones in human, mouse for CCL27 (see all 5)
OriGene ORF clones in mouse, rat for CCL27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL27 (NM_006664)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL27
Sirion Biotech Customized lentivirus for stable overexpression of CCL27 
                     Customized lentivirus expression plasmids for stable overexpression of CCL27 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CCL27
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL27
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL27
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL27

Additional mRNA sequence: 

AB010445.1 AF082393.1 AJ243542.1 BC148263.1 

4 DOTS entries:

DT.91660436  DT.100676503  DT.100020148  DT.95222601 

24/62 AceView cDNA sequences (see all 62):

AF082393 BX458782 AB010445 AI203673 BX396625 AI629021 BM719357 BX282529 
CR625131 NM_006664 AI216900 CA433929 AW304455 AI652758 BI915273 BM796593 
AI949596 AI200754 AJ243542 BE503435 AI032379 AI022040 BC066358 BC037171 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGACTCTGCC
CCL27 Expression
About this image


See CCL27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL27

SOURCE GeneReport for Unigene cluster: Hs.648124

UniProtKB/Swiss-Prot: CCL27_HUMAN, Q9Y4X3
Tissue specificity: Testis, thymus, placenta, ovary and skin

    SABiosciences Expression via Pathway-Focused PCR Arrays including CCL27: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL27
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL27
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL27
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL27

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL27 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccl27a1 , 5 chemokine (C-C motif) ligand 27A1, 5 76.58(n)1
61.26(a)1
  4 (22.08 cM)5
203011  NM_011336.11  NP_035466.11 
 417694675 
lizard
(Anolis carolinensis)
Reptilia --
--
20(a)
1 → many
2(6107171-6118573)


ENSEMBL Gene Tree for CCL27 (if available)
TreeFam Gene Tree for CCL27 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CCL27 gene
CCL282  
1 SIMAP similar gene for CCL27 using alignment to 2 protein entries:     CCL27_HUMAN (see all proteins):
CCL28

CCL27 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/25 SNPs in CCL27 are shown (see all 25)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0221034
----see VAR_0221032 I V mis40--------
VAR_0221044
----see VAR_0221042 L F mis40--------
rs115755951,2
C,F--34662431(+) GGGCCA/GTGTGT 1 -- int15Minor allele frequency- G:0.01NS CSA WA EU 1516
rs790153461,2
C,F--34662445(+) GAGGGA/GTCCTG 1 -- int12Minor allele frequency- G:0.00EA EU 1397
rs115755961,2
C--34662450(+) ATCCTG/AACCAA 1 -- int13Minor allele frequency- A:0.02NS WA 212
rs1849378221,2
C,F--34662540(+) AGCTTT/CCTATA 1 -- int11Minor allele frequency- C:0.01EU 1263
rs1417331481,2
C--34662623(+) GGGGCC/TCCTTC 2 E G mis11Minor allele frequency- T:0.00NA 4550
rs2000672901,2
--34662661(+) TCTCTC/GTCTCC 1 -- ut510--------
rs777837051,2
C--34662754(+) GTGACA/GCTCCT 1 -- us2k10--------
rs115755971,2
C,F--34662809(+) AGGATA/GGCCAT 1 -- us2k12Minor allele frequency- G:0.02NS 72

HapMap Linkage Disequilibrium report for CCL27 (34661877 - 34664045 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CCL27:    About this table     
Variant IDTypeSubtypePubMed ID
nsv893038CNV Loss21882294
nsv818699CNV Gain17921354
nsv831544CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CCL27
DNA2.0 Custom Variant and Variant Library Synthesis for CCL27

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604833    OMIM disorders: --

20/62 diseases for CCL27 (see all 62):    About MalaCards
chronic recurrent multifocal osteomyelitis    exanthem    sezary's disease    allergic contact dermatitis
obstructive jaundice    hypophosphatasia    contact dermatitis    onchocerciasis
primary biliary cirrhosis    adult t-cell leukemia    osteomyelitis    cutaneous lupus erythematosus
atopic dermatitis    hiv/aids    molluscum contagiosum    gallbladder cancer
primary hyperparathyroidism    alopecia areata    eczema    dermatitis

4 diseases from the University of Copenhagen DISEASES database for CCL27:
Atopic dermatitis     Allergic contact dermatitis     Mycosis fungoides     Sezary's disease

CCL27 for disorders           About GeneDecksing

10/22 Novoseek inferred disease relationships for CCL27 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dermatitis atopic 68.2 20 16499646 (3), 12642842 (2), 15115514 (2), 18266834 (2) (see all 11)
liver dysfunction 50.5 3 1527903 (1), 11868363 (1), 16549178 (1)
skin diseases 46.4 4 10725697 (1), 15316512 (1), 12642842 (1)
psoriasis 42.3 6 12642842 (2), 15577845 (1), 14510975 (1)
necrosis 39.9 14 15335355 (1), 20512474 (1), 16784723 (1), 18070806 (1) (see all 11)
skin lesion 35.8 3 15577845 (1), 17071491 (1), 18266834 (1)
eczema 34.5 2 16499646 (2)
dermatitis 32.4 3 15577845 (1), 18782672 (1), 11821900 (1)
inflammation 26.6 10 15307136 (1), 14522130 (1), 16499646 (1), 19399744 (1) (see all 6)
dermatitis allergic contact 17.4 2 17581202 (2)

Genetic Association Database (GAD): CCL27
Human Genome Epidemiology (HuGE) Navigator: CCL27 (8 documents)

Export disorders for CCL27 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CCL27 gene, integrated from 9 sources (see all 157):
(articles sorted by number of sources associating them with CCL27)
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  1. CTACK, a skin-associated chemokine that preferentially attracts skin- homing memory T cells. (PubMed id 10588729)1, 2, 3, 9 Morales J.... Zlotnik A. (1999)
  2. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. (PubMed id 10556532)1, 2, 3 Ishikawa-Mochizuki I.... Yoshie O. (1999)
  3. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PubMed id 10725697)1, 2, 9 Homey B.... Zlotnik A. (2000)
  4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  7. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
  9. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. (PubMed id 12642842)1, 9 Kakinuma T....Tamaki K. (2003)
  10. Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. (PubMed id 14767451)1, 9 Hijnen D....Knol E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10850 HGNC: 10626 AceView: CCL27 Ensembl:ENSG00000213927 euGenes: HUgn10850
ECgene: CCL27 Kegg: 10850 H-InvDB: CCL27

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CCL27 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL27

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCL27 gene:
Search GeneIP for patents involving CCL27

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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