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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL26 Gene

protein-coding   GIFtS: 59
GCID: GC07M075398

chemokine (C-C motif) ligand 26

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA26)
 Explore 51 diseases affiliated with
CCL26 via our new
 Human Malady Compendium 
Biological research products
for CCL26
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 261 2     Small-Inducible Cytokine A262 3
SCYA261 2 3 5     Thymic Stroma Chemokine-12 3
TSC-11 2 3     MIP-4-Alpha1
IMAC1 2     CC Chemokine IMAC2 3
MIP-4a1 2     C-C Motif Chemokine 262
MIP-4alpha1 2     Chemokine N12
Eotaxin-33     Small Inducible Cytokine A262
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 261 2     Eotaxin-33
Macrophage Inflammatory Protein 4-Alpha2 3     

External Ids:    HGNC: 106251   Entrez Gene: 103442   Ensembl: ENSG000000066067   OMIM: 6046975   UniProtKB: Q9Y2583   

Export aliases for CCL26 gene to outside databases

Previous GC identifers: GC07M073934 GC07M074997 GC07M075010 GC07M075043 GC07M075236 GC07M070484


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL26:
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood
eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate
chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
Function: Chemotactic for eosinophils and basophils. Binds to CCR3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL26 gene promoter:
         IRF-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL26 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.2

CCL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL26 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075398:  view genomic region     (about GC identifiers)

Start:
75,398,842 bp from pter      End:
75,419,214 bp from pter
Size:
20,373 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,731,906-74,752,128     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258 (See protein sequence)
Recommended Name: C-C motif chemokine 26 precursor  
Size: 94 amino acids; 10648 Da
Subunit: Monomer
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CCL26:
1G2S (3D)        1G2T (3D)    
Secondary accessions: A0N0Q5 Q52LV8

Explore the universe of human proteins at neXtProt for CCL26: NX_Q9Y258

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y258

  • CCL26 Protein expression data from MOPED and PaxDb:    About this image 
    CCL26 Protein Expression
    REFSEQ proteins: NP_006063.1  
    ENSEMBL proteins: 
     ENSP00000005180   ENSP00000378365  

    Human Recombinant Protein Products for CCL26: 
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    OriGene Protein Over-expression Lysate: CCL26
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    Novus Biologicals CCL26 Proteins
    Novus Biologicals CCL26 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL26
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    CCL26 for ontologies           About GeneDecksing



    CCL26 Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCL26 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y258

    ProtoNet protein and cluster: Q9Y258

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL26_HUMAN, Q9Y258
    Function: Chemotactic for eosinophils and basophils. Binds to CCR3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    CCL26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCL26:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCL26 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL26
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    SwitchGear 3'UTR luciferase reporter plasmidCCL26 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL26 (see all 7)
    OriGene shRNA RFP: CCL26
    OriGene siRNA: CCL26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL26
    Sirion Biotech Custom design and validation of potent shRNA sequences against CCL26 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCL26 
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CCL26 (NM_006072)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL26 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for CCL26

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL26


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    PEDF Induced Signaling1.00
    STAT3 Pathway0.47
    MIF Mediated Glucocorticoid Regulation0.73
    Endothelin-1 Signaling Pathway0.44
    MIF Regulation of Innate Immune Cells0.71
    NFAT Signaling and Lymphocyte Interactions0.37
    IL-6 Pathway0.61
    PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    TGF-Beta Pathway1.00
    JNK Pathway0.50
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.29
    3Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Rho Family GTPases
    Rho Family GTPases1.00
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5Immune response _CCR3 signaling in eosinophils
    Immune response _CCR3 signaling in eosinophils1.00
    Immune response CCR3 signaling in eosinophils1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCL26
        Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL26 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL26
        Immune response CCR3 signaling in eosinophils

    1 BioSystems Pathway for CCL26 
        IL4-mediated signaling events


    2         Kegg Pathways  (Kegg details for CCL26):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL26 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for CCL26 (Q9Y2582, 3 ENSP000000051804) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    STAT6ENSP000003001344STRING: ENSP00000300134
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19525930
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS10373330

    CCL26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL26 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL26
    10/12 Novoseek chemical compound relationships for CCL26 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 68.3 7 20457704 (1), 15186745 (1), 19692352 (1), 15578690 (1) (see all 7)
    imac 66.7 26 7511601 (7), 16829228 (2), 9132420 (2), 16814324 (2) (see all 6)
    tarc 63.3 8 17564846 (3), 19236470 (1), 15591886 (1), 11964742 (1)
    rantes 62.2 10 11286614 (3), 15044249 (2), 16385249 (2), 12450563 (1) (see all 6)
    erythrosine 53.5 1 7511601 (1)
    ccl3 36.9 2 17350279 (1)
    fluorescein 8.4 1 7511601 (1)
    atp 0 1 7511601 (1)
    oxygen 0 3 12784909 (1), 16829228 (1), 11286614 (1)
    calcium 0 2 12689946 (1), 10488147 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL26 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL26 gene: 
    NM_006072.4  

    Unigene Cluster for CCL26:

    Chemokine (C-C motif) ligand 26
    Hs.131342  [show with all ESTs]
    Unigene Representative Sequence: AY358893
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005180 ENST00000394905(uc003udt.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL26
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    SwitchGear 3'UTR luciferase reporter plasmidCCL26 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL26 (see all 7)
    OriGene shRNA RFP: CCL26
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CCL26 
    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL26 (NM_006072)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL26 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL26

    Additional cDNA sequence: 

    AB010447.1 AB016542.1 AF096296.1 AF124601.1 AF142434.1 AY358893.1 BC069394.1 BC093773.1 
    BC101665.1 

    1 DOTS entry:

    DT.101080 

    24/41 AceView cDNA sequences (see all 41):

    AI656496 AF096296 AI186047 AF124601 AY358893 AB016542 BM931248 AI359498 
    AI990509 NM_006072 BX103172 AF142434 AI968833 AI916053 AI657118 AW593707 
    BC069394 AI739613 AI655148 AB010447 AA926779 AI928371 BQ189479 BF590082 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCCGCTGG
    CCL26 Expression
    About this image
    See CCL26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL26

    SOURCE GeneReport for Unigene cluster: Hs.131342

    UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
    Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL26: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL26 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1937066
    si:dkeyp-59a8.26
    (see all 6)
    si:dkeyp-59a8.2
    (see all 6)
    29(a)
    26(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    25(25902180-25904281)
    20(38304232-38305101)


    ENSEMBL Gene Tree for CCL26 (if available)
    TreeFam Gene Tree for CCL26 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL26 gene
    CCL152  CCL162  CCL22  CCL142  CCL242  CCL4L12  CCL112  CCL72  
    CCL4L22  CCL3L12  CCL52  CCL232  CCL3L32  CCL42  CCL82  CCL132  
    CCL32  CCL182  
    18/30 SIMAP similar genes for CCL26 using alignment to 1 protein entry:     CCL26_HUMAN(see all similar genes):
    CCL4L2    LOC728835    CCL5    CCL3    CCL3L1    CCL3L3
    CCL4    CCL4L1    CCL17    CCL11    CCL2    CCL23
    CCL19    CCL20    CCL14    CCL24    CCL18    CCL13

    CCL26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/502 NCBI SNPs in CCL26 are shown (see all 502    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138394331,2
    F--74731782(+) AAAAAG/CCCACG 1 -- ds50012Minor allele frequency- C:0.50CSA 4
    rs114653501,2
    C,F,H--74731832(-) TTGCCT/CGGGAG 1 -- ds50018Minor allele frequency- C:0.06NA EU NS EA WA 630
    rs23020081,2
    C,F,H--74732257(-) CTAGTG/AAGAGA 1 -- int120Minor allele frequency- A:0.06EA NA EU NS CSA WA 3505
    rs114653431,2
    C,F,H--74733190(-) AGCCCA/GGTTAC 1 -- int17Minor allele frequency- G:0.01NA EU NS EA 504
    rs114653421,2
    C,F--74733207(-) GGTGGC/GGCAGG 1 -- int14Minor allele frequency- G:0.03NA EU WA 210
    rs1136999811,2
    F--74733345(+) CAACCG/AAAGGA 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs114653411,2
    C,F,H--74733369(-) CACCGA/GGTTTT 1 -- int111Minor allele frequency- G:0.03NA EU NS EA WA 1300
    rs114653401,2
    C,F,H--74733473(-) AAGAGA/GAAAAA 1 -- int1 trp39Minor allele frequency- G:0.06NA EU NS EA CSA WA 632
    rs114653381,2
    C,F,H--74733743(-) AATGTG/AGCTAA 1 -- int18Minor allele frequency- A:0.01NA EU NS EA WA 624
    rs778047251,2
    C--74733943(+) TAACAC/TAAAAA 1 -- int12Minor allele frequency- T:0.04NA 122

    HapMap Linkage Disequilibrium report for CCL26 (75398842 - 75419214 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CCL26
         3 CNVs: 3686 69961 22956
    Human Gene Mutation Database (HGMD): CCL26

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCL26 for disorders           About GeneDecksing

    OMIM gene information: 604697    OMIM disorders: --

    20/51 diseases for CCL26 (see all 51):    About MalaCards
    churg-strauss syndrome    perivascular epithelioid cell tumor    age related macular degeneration    gastroesophageal reflux disease
    tuberous sclerosis    macular degeneration    bullous pemphigoid    amyotrophic lateral sclerosis
    angiomatosis    angiofibroma    lateral sclerosis    angiomyolipoma
    eosinophilic esophagitis    allergic rhinitis    polycystic kidney disease    hemimegalencephaly
    atopic dermatitis    transitional cell carcinoma    eosinophilia    allergic asthma

    3 diseases from the University of Copenhagen DISEASES database for CCL26:
    Asthma     Atopic dermatitis     Eosinophilic esophagitis

    10/31 Novoseek disease relationships for CCL26 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 91.2 48 14633685 (2), 11281455 (2), 10029074 (2), 8824721 (2) (see all 40)
    angiomyolipoma 76.1 1 20457704 (1)
    hamartoma 75.7 12 11468687 (3), 7849709 (2), 8824721 (2), 20146692 (1) (see all 8)
    rhabdomyoma 71.2 4 16940165 (2), 10340649 (1), 11357016 (1)
    esophagitis 64.8 10 17900656 (5), 20208004 (1), 16842447 (1), 16453027 (1) (see all 5)
    renal cyst 56.1 1 12647363 (1)
    phakomatosis 55.4 2 18496427 (1), 12436247 (1)
    eosinophilia 55 9 15947325 (3), 15805998 (2), 17073866 (1), 18397958 (1) (see all 6)
    heart tumor 51.5 1 11357016 (1)
    asthma 48.2 12 15207712 (3), 16304252 (2), 15784470 (1), 16604488 (1) (see all 8)

    Genetic Association Database (GAD): CCL26
    Human Genome Epidemiology (HuGE) Navigator: CCL26 (16 documents)

    Export disorders for CCL26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL26 gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with CCL26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PubMed id 10373330)1, 2, 3, 9 Guo R.F.... Shi M.M. (1999)
    2. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. (PubMed id 10488147)1, 2, 9 Kitaura M.... Yoshie O. (1999)
    3. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3. (PubMed id 11425309)1, 2, 9 Ye J.... Stone M.J. (2001)
    4. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. (PubMed id 10415065)1, 2, 9 Shinkai A....Nishi T. (1999)
    5. Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. (PubMed id 15784470)1, 4, 9 Chae S.C....Chung H.T. (2005)
    6. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PubMed id 16391516)1, 4, 9 Park Y.R....Chung H.T. (2005)
    7. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PubMed id 15207712)1, 4, 9 Chae S.C....Chung H.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10344 HGNC: 10625 AceView: CCL26 Ensembl:ENSG00000006606 euGenes: HUgn10344
    ECgene: CCL26 Kegg: 10344 H-InvDB: CCL26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL26 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL26

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL26 gene:
    Search GeneIP for patents involving CCL26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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