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Aliases for CCL26 Gene

Aliases for CCL26 Gene

  • Chemokine (C-C Motif) Ligand 26 2 3
  • Macrophage Inflammatory Protein 4-Alpha 2 3 4
  • Thymic Stroma Chemokine-1 2 3 4
  • CC Chemokine IMAC 2 3 4
  • Eotaxin-3 2 3 4
  • SCYA26 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 26 2 3
  • Small Inducible Cytokine A26 2 3
  • Small-Inducible Cytokine A26 3 4
  • Chemokine N1 2 3
  • MIP-4-Alpha 3 4
  • TSC-1 3 4
  • C-C Motif Chemokine 26 3
  • MIP-4alpha 3
  • MIP-4a 3
  • IMAC 3

External Ids for CCL26 Gene

Previous Symbols for CCL26 Gene

  • SCYA26

Summaries for CCL26 Gene

Entrez Gene Summary for CCL26 Gene

  • This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL26 Gene

CCL26 (Chemokine (C-C Motif) Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include heart tumor and esophagitis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL26 Gene

  • Chemotactic for eosinophils and basophils. Binds to CCR3

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL26 Gene

Genomics for CCL26 Gene

Genomic Location for CCL26 Gene

Start:
75,769,524 bp from pter
End:
75,789,896 bp from pter
Size:
20,373 bases
Orientation:
Minus strand

Genomic View for CCL26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL26 Gene

Regulatory Elements for CCL26 Gene

Proteins for CCL26 Gene

  • Protein details for CCL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y258-CCL26_HUMAN
    Recommended name:
    C-C motif chemokine 26
    Protein Accession:
    Q9Y258
    Secondary Accessions:
    • A0N0Q5
    • Q52LV8

    Protein attributes for CCL26 Gene

    Size:
    94 amino acids
    Molecular mass:
    10648 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for CCL26 Gene

neXtProt entry for CCL26 Gene

Proteomics data for CCL26 Gene at MOPED

Post-translational modifications for CCL26 Gene

No Post-translational modifications

Other Protein References for CCL26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL26 Gene

Domains for CCL26 Gene

Gene Families for CCL26 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL26 Gene

UniProtKB/Swiss-Prot:

CCL26_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • Q9Y258
genes like me logo Genes that share domains with CCL26: view

Function for CCL26 Gene

Molecular function for CCL26 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for eosinophils and basophils. Binds to CCR3

Gene Ontology (GO) - Molecular Function for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL26: view

Phenotypes for CCL26 Gene

GenomeRNAi human phenotypes for CCL26:
genes like me logo Genes that share phenotypes with CCL26: view

miRNA for CCL26 Gene

miRTarBase miRNAs that target CCL26

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL26 Gene

Localization for CCL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL26 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL26 Gene COMPARTMENTS Subcellular localization image for CCL26 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL26: view

Pathways for CCL26 Gene

genes like me logo Genes that share pathways with CCL26: view

Pathways by source for CCL26 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CCL26 Gene
1 BioSystems pathway for CCL26 Gene

Interacting Proteins for CCL26 Gene

Selected Interacting proteins: Q9Y258-CCL26_HUMAN for CCL26 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0006935 chemotaxis TAS 10373330
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS 10373330
genes like me logo Genes that share ontologies with CCL26: view

Compounds for CCL26 Gene

(12) Novoseek inferred chemical compound relationships for CCL26 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 68.3 7
imac 66.7 15
tarc 63.3 6
rantes 62.2 10
erythrosine 53.5 1
genes like me logo Genes that share compounds with CCL26: view

Transcripts for CCL26 Gene

mRNA/cDNA for CCL26 Gene

Unigene Clusters for CCL26 Gene

Chemokine (C-C motif) ligand 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL26 Gene

No ASD Table

Relevant External Links for CCL26 Gene

GeneLoc Exon Structure for
CCL26
ECgene alternative splicing isoforms for
CCL26

Expression for CCL26 Gene

mRNA expression in normal human tissues for CCL26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL26 Gene

This gene is overexpressed in Ovary (12.6), Nerve - Tibial (5.7), and Pituitary (4.1).

SOURCE GeneReport for Unigene cluster for CCL26 Gene Hs.131342

mRNA Expression by UniProt/SwissProt for CCL26 Gene

Q9Y258-CCL26_HUMAN
Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary
genes like me logo Genes that share expressions with CCL26: view

Orthologs for CCL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL26 36
  • 98.94 (n)
  • 96.81 (a)
CCL26 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 37 (a)
ManyToMany
CCL26 36
  • 74.11 (n)
  • 58.51 (a)
dog
(Canis familiaris)
Mammalia CCL26 36
  • 76.7 (n)
  • 60.22 (a)
CCL26 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl26 16
Ccl26 37
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GGCL1 37
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZGC:193706 37
  • 32 (a)
OneToMany
Species with no ortholog for CCL26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCL26 Gene

ENSEMBL:
Gene Tree for CCL26 (if available)
TreeFam:
Gene Tree for CCL26 (if available)

Paralogs for CCL26 Gene

genes like me logo Genes that share paralogs with CCL26: view

No data available for Paralogs for CCL26 Gene

Variants for CCL26 Gene

Sequence variations from dbSNP and Humsavar for CCL26 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1055426 -- 75,769,613(-) CTTTT(C/T)TGAAG utr-variant-3-prime
rs1079953 -- 75,790,321(-) AGGGA(C/G)CTATG upstream-variant-2KB
rs2018179 -- 75,772,668(-) GTTTG(G/T)TTTTT intron-variant, upstream-variant-2KB
rs2240478 -- 75,772,100(-) ACGTA(C/T)GTAGC intron-variant
rs2302008 -- 75,769,875(-) CTAGT(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL26 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
nsv518028 CNV Gain 19592680
nsv888385 CNV Loss 21882294
esv23585 CNV Loss 19812545

Relevant External Links for CCL26 Gene

HapMap Linkage Disequilibrium report
CCL26
Human Gene Mutation Database (HGMD)
CCL26

Disorders for CCL26 Gene

(3) University of Copenhagen DISEASES for CCL26 Gene

(31) Novoseek inferred disease relationships for CCL26 Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 91.2 46
angiomyolipoma 76.1 1
hamartoma 75.7 12
rhabdomyoma 71.2 4
esophagitis 64.8 9

Relevant External Links for CCL26

Genetic Association Database (GAD)
CCL26
Human Genome Epidemiology (HuGE) Navigator
CCL26
genes like me logo Genes that share disorders with CCL26: view

No data available for UniProtKB/Swiss-Prot for CCL26 Gene

Publications for CCL26 Gene

  1. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PMID: 10373330) Guo R.F. … Shi M.M. (Genomics 1999) 2 3 4 23
  2. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. (PMID: 10415065) Shinkai A. … Nishi T. (J. Immunol. 1999) 3 4 23
  3. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. (PMID: 10488147) Kitaura M. … Yoshie O. (J. Biol. Chem. 1999) 3 4 23
  4. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3. (PMID: 11425309) Ye J. … Stone M.J. (Biochemistry 2001) 3 4 23
  5. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PMID: 15207712) Chae S.C. … Chung H.T. (Biochem. Biophys. Res. Commun. 2004) 3 23 49

Products for CCL26 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL26
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL26
    • Block miRNA regulation of CCL26 using miScript Target Protectors

    Sources for CCL26 Gene

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