Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL26 Gene

protein-coding   GIFtS: 61
GCID: GC07M075398

Chemokine (C-C Motif) Ligand 26

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 26)
(Previous symbol: SCYA26)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 261 2     Small-Inducible Cytokine A262 3
SCYA261 2 3 5     MIP-4-alpha2 3
CC Chemokine IMAC1 2 3     TSC-12 3
Macrophage Inflammatory Protein 4-Alpha1 2 3     IMAC2
Thymic Stroma Chemokine-11 2 3     MIP-4a2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 261 2     MIP-4alpha2
Chemokine N11 2     C-C Motif Chemokine 262
eotaxin-31 2     Eotaxin-33
Small Inducible Cytokine A261 2     

External Ids:    HGNC: 106251   Entrez Gene: 103442   Ensembl: ENSG000000066067   OMIM: 6046975   UniProtKB: Q9Y2583   

Export aliases for CCL26 gene to outside databases

Previous GC identifers: GC07M073934 GC07M074997 GC07M075010 GC07M075043 GC07M075236 GC07M070484


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL26 Gene:
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family
of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for
normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines
that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation
in atopic diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL26 Gene: 
CCL26 (chemokine (C-C motif) ligand 26) is a protein-coding gene. Diseases associated with CCL26 include eosinophilic esophagitis, and heart tumor, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
Function: Chemotactic for eosinophils and basophils. Binds to CCR3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL26 gene promoter:
         IRF-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL26 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.2

CCL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL26 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075398:  view genomic region     (about GC identifiers)

Start:
75,398,842 bp from pter      End:
75,419,214 bp from pter
Size:
20,373 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,731,906-74,752,128     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258 (See protein sequence)
Recommended Name: C-C motif chemokine 26 precursor  
Size: 94 amino acids; 10648 Da
Subunit: Monomer
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CCL26:
1G2S (3D)        1G2T (3D)    
Secondary accessions: A0N0Q5 Q52LV8

Explore the universe of human proteins at neXtProt for CCL26: NX_Q9Y258

Explore proteomics data for CCL26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y258

  • CCL26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL26 Protein Expression
    REFSEQ proteins: NP_006063.1  
    ENSEMBL proteins: 
     ENSP00000005180   ENSP00000378365  

    Human Recombinant Protein Products for CCL26: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL26 (CCL26/Eotaxin-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL26
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCL26
    GenScript Purified and Recombinant Proteins for CCL26
    Novus Biologicals CCL26 Proteins
    Novus Biologicals CCL26 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL26
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CCL26 for ontologies           About GeneDecksing



    CCL26 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL26 (CCL26/Eotaxin-3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL26
    GenScript Superior Antibodies for CCL26
    Novus Biologicals CCL26 Antibodies
    Abcam antibodies for CCL26
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CCL26
    LSBio Antibodies in human, mouse, rat for CCL26 

    Assay Products for CCL26: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL26
    R&D Systems ELISAs for CCL26 (CCL26/Eotaxin-3)         (see all)
    GenScript Custom Assay Services for CCL26
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y258

    ProtoNet protein and cluster: Q9Y258

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL26_HUMAN, Q9Y258
    Function: Chemotactic for eosinophils and basophils. Binds to CCR3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    CCL26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCL26:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL26 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL26 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL26 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL26
    SwitchGear 3'UTR luciferase reporter plasmidCCL26 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL26

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL26
    Sirion Biotech Customized adenovirus for overexpression of CCL26

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL26 (see all 6)
    OriGene ORF clones in mouse, rat for CCL26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL26 (NM_006072)
    Sino Biological Human cDNA Clone for CCL26
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL26
    Sirion Biotech Customized lentivirus for stable overexpression of CCL26 
                         Customized lentivirus expression plasmids for stable overexpression of CCL26 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL26
    Search LifeMap BioReagents cell lines for CCL26
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL26


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL26 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL26
        Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL26 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL26
        Immune response CCR3 signaling in eosinophils

    1 BioSystems Pathway for CCL26
        IL4-mediated signaling events



    2         Kegg Pathways  (Kegg details for CCL26):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL26 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for CCL26 (Q9Y2582, 3 ENSP000000051804) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    STAT6ENSP000003001344STRING: ENSP00000300134
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19525930
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS10373330

    CCL26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL26 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL26

    10/12 Novoseek inferred chemical compound relationships for CCL26 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 68.3 7 20457704 (1), 15186745 (1), 19692352 (1), 15578690 (1) (see all 7)
    imac 66.7 26 7511601 (7), 16829228 (2), 9132420 (2), 16814324 (2) (see all 6)
    tarc 63.3 8 17564846 (3), 19236470 (1), 15591886 (1), 11964742 (1)
    rantes 62.2 10 11286614 (3), 15044249 (2), 16385249 (2), 12450563 (1) (see all 6)
    erythrosine 53.5 1 7511601 (1)
    ccl3 36.9 2 17350279 (1)
    fluorescein 8.4 1 7511601 (1)
    atp 0 1 7511601 (1)
    oxygen 0 3 12784909 (1), 16829228 (1), 11286614 (1)
    calcium 0 2 12689946 (1), 10488147 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL26 gene: 
    NM_006072.4  

    Unigene Cluster for CCL26:

    Chemokine (C-C motif) ligand 26
    Hs.131342  [show with all ESTs]
    Unigene Representative Sequence: AY358893
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005180 ENST00000394905(uc003udt.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL26
    SwitchGear 3'UTR luciferase reporter plasmidCCL26 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL26
    Clone
    Products:
         
    OriGene clones in human, mouse for CCL26 (see all 6)
    OriGene ORF clones in mouse, rat for CCL26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL26 (NM_006072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL26
    Sirion Biotech Customized lentivirus for stable overexpression of CCL26 
                         Customized lentivirus expression plasmids for stable overexpression of CCL26 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL26
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL26
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL26
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL26

    Additional mRNA sequence: 

    AB010447.1 AB016542.1 AF096296.1 AF124601.1 AF142434.1 AY358893.1 BC069394.1 BC093773.1 
    BC101665.1 

    1 DOTS entry:

    DT.101080 

    24/41 AceView cDNA sequences (see all 41):

    BM931248 AF096296 AI186047 AY358893 AI990509 BX103172 AI359498 AB016542 
    NM_006072 AI656496 AF124601 AF142434 AI968833 AI657118 AW294854 BQ189479 
    AW593707 AI916052 AA716120 BC069394 AB010447 AI739613 AI916053 BF590082 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL26 expression in normal human tissues (normalized intensities)      CCL26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCGCTGG
    CCL26 Expression
    About this image


    CCL26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             monocyte-derived dendritic cells   

    See CCL26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL26

    SOURCE GeneReport for Unigene cluster: Hs.131342

    UniProtKB/Swiss-Prot: CCL26_HUMAN, Q9Y258
    Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL26: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL26
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL26
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL26
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL26
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL26 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl265 chemokine (C-C motif) ligand 26   --   5 (75.27 cM) 135560448 
    chicken
    (Gallus gallus)
    Aves CCL46
    chemokine-like ligand 1 precursor
    32(a)
    1 ↔ 1
    19(352190-372634)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.26
    si:dkeyp-59a8.16
    (see all 5)
    si:dkeyp-59a8.1
    (see all 5)
    27(a)
    25(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38304232-38305101)
    20(38282475-38302293)


    ENSEMBL Gene Tree for CCL26 (if available)
    TreeFam Gene Tree for CCL26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL26 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL32  CCL52  
    CCL232  CCL3L32  CCL42  CCL182  CCL15-CCL142  
    18/30 SIMAP similar genes for CCL26 using alignment to 1 protein entry:     CCL26_HUMAN(see all similar genes):
    CCL4L2    LOC728835    CCL5    CCL3    CCL3L1    CCL3L3
    CCL4    CCL4L1    CCL17    CCL11    CCL2    CCL23
    CCL19    CCL20    CCL14    CCL24    CCL18    CCL13

    CCL26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/631 SNPs in CCL26 are shown (see all 631)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486318091,2
    C--70507280(+) TAAGG-/TTTTTT 1 -- us2k10--------
    rs1912162301,2
    --70507310(+) TGAGAC/TAGGGT 1 -- us2k10--------
    rs1810968431,2
    --70507364(+) CTCACA/GGCAGC 1 -- us2k10--------
    rs1127192531,2
    C--74740205(+) TTTTTT/-GAGAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs1116994371,2
    C,F--74742108(+) GATCAC/TCGCAG 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs132418981,2
    H--74742945(+) tccttC/Aaagat 1 -- int14Minor allele frequency- A:0.00NS EA 412
    rs561045071,2
    C--74750081(+) GCCTC-/TCAACT 1 -- int10--------
    rs731346781,2
    C--74752398(+) TCCCTC/TCCTTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1173453301,2
    F--74752402(+) TCCCTT/CCCTTC 1 -- us2k12Minor allele frequency- C:0.12NA EA 240
    rs39032251,2
    C--74752560(-) gaaagG/Aaagga 1 -- us2k11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for CCL26 (75398842 - 75419214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CCL26:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv120n16CNV Deletion17901297
    nsv888385CNV Loss21882294
    esv23585CNV Loss19812545
    nsv528969CNV Gain19592680
    nsv518028CNV Gain19592680
    essv14753CNV CNV17122850


    Human Gene Mutation Database (HGMD): CCL26
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCL26
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604697    OMIM disorders: --

    20/49 diseases for CCL26 (see all 49):    About MalaCards
    eosinophilic esophagitis    heart tumor    angiomatosis    hemimegalencephaly
    perivascular epithelioid cell tumor    tuberous sclerosis    tuberous sclerosis complex    aortic disease
    bullous pemphigoid    churg-strauss syndrome    allergic asthma    angiomyolipoma
    lymphangioleiomyomatosis    gastroesophageal reflux disease    cystic kidney    eosinophilia
    chordoma    age related macular degeneration    cutaneous t cell lymphoma    macular degeneration

    3 diseases from the University of Copenhagen DISEASES database for CCL26:
    Asthma     Atopic dermatitis     Eosinophilic esophagitis

    CCL26 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/31 Novoseek inferred disease relationships for CCL26 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 91.2 48 14633685 (2), 11281455 (2), 10029074 (2), 8824721 (2) (see all 40)
    angiomyolipoma 76.1 1 20457704 (1)
    hamartoma 75.7 12 11468687 (3), 7849709 (2), 8824721 (2), 20146692 (1) (see all 8)
    rhabdomyoma 71.2 4 16940165 (2), 10340649 (1), 11357016 (1)
    esophagitis 64.8 10 17900656 (5), 20208004 (1), 16842447 (1), 16453027 (1) (see all 5)
    renal cyst 56.1 1 12647363 (1)
    phakomatosis 55.4 2 18496427 (1), 12436247 (1)
    eosinophilia 55 9 15947325 (3), 15805998 (2), 17073866 (1), 18397958 (1) (see all 6)
    heart tumor 51.5 1 11357016 (1)
    asthma 48.2 12 15207712 (3), 16304252 (2), 15784470 (1), 16604488 (1) (see all 8)

    Genetic Association Database (GAD): CCL26
    Human Genome Epidemiology (HuGE) Navigator: CCL26 (16 documents)

    Export disorders for CCL26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL26 gene, integrated from 9 sources (see all 216):
    (articles sorted by number of sources associating them with CCL26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PubMed id 10373330)1, 2, 3, 9 Guo R.F.... Shi M.M. (1999)
    2. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. (PubMed id 10488147)1, 2, 9 Kitaura M.... Yoshie O. (1999)
    3. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3. (PubMed id 11425309)1, 2, 9 Ye J.... Stone M.J. (2001)
    4. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. (PubMed id 10415065)1, 2, 9 Shinkai A....Nishi T. (1999)
    5. Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. (PubMed id 15784470)1, 4, 9 Chae S.C....Chung H.T. (2005)
    6. [The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma] (PubMed id 16604488)1, 4, 9 Gao G.M....He Z.Q. (2006)
    7. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PubMed id 16391516)1, 4, 9 Park Y.R....Chung H.T. (2005)
    8. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PubMed id 15207712)1, 4, 9 Chae S.C....Chung H.T. (2004)
    9. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10344 HGNC: 10625 AceView: CCL26 Ensembl:ENSG00000006606 euGenes: HUgn10344
    ECgene: CCL26 Kegg: 10344 H-InvDB: CCL26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL26 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL26

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL26 gene:
    Search GeneIP for patents involving CCL26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCL26 (CCL26/Eotaxin-3)   Browse Cell Culture Products  
     ELISAs for CCL26 (CCL26/Eotaxin-3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CCL26 (CCL26/Eotaxin-3)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CCL26 (CCL26/Eotaxin-3)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCL26  
     OriGene qPCR primer pairs and template standards for CCL26   OriGene Protein Over-expression Lysate for CCL26  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCL26  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCL26   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCL26   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCL26   OriGene Custom Protein Services for CCL26  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL26
     QIAGEN SeqTarget long-range PCR primers for resequencing CCL26
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL26
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL26
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL26
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL26
     GenScript Purified and Recombinant Proteins for CCL26 GenScript cDNA clones with any tag delivered in your preferred vector for CCL26
     GenScript Custom Assay Services for CCL26 GenScript Superior Antibodies for CCL26
     GenScript Custom overexpressing Cell Line Services for CCL26 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCL26 promoter
     Search Chromatin IP Primers for CCL26
     RT2 qPCR Primer Assay in human, mouse / rat CCL26
     GNC Network for CCL26
     SABiosciences PCR Arrays including human, mouse / rat CCL26
     Search Tocris compounds for CCL26
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCL26
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCL26 antibodies
     CCL26 proteins
     CCL26 lysates
     Antibodies for CCL26
     See all of Abcam's Antibodies, Kits and Proteins for CCL26
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CCL26




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CCL26
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL26
     SwitchGear 3'UTR luciferase reporter plasmids for CCL26
     SwitchGear Promoter luciferase reporter plasmids for CCL26
     Search ThermoFisher Antibodies for CCL26
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL26
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL26
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL26
    Customized:
     lentivirus for stable overexpression of CCL26
     lentivirus expression plasmids for stable overexpression of CCL26
     adenovirus for overexpression of CCL26
     LSBio Antibodies in human, mouse, rat for CCL26
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCL26 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4