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Aliases for CCL26 Gene

Aliases for CCL26 Gene

  • C-C Motif Chemokine Ligand 26 2 3 5
  • Macrophage Inflammatory Protein 4-Alpha 2 3 4
  • Thymic Stroma Chemokine-1 2 3 4
  • CC Chemokine IMAC 2 3 4
  • Eotaxin-3 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 26 2 3
  • Chemokine (C-C Motif) Ligand 26 2 3
  • Small Inducible Cytokine A26 2 3
  • Chemokine N1 2 3
  • MIP-4-Alpha 3 4
  • SCYA26 3 4
  • TSC-1 3 4
  • Small-Inducible Cytokine A26 4
  • C-C Motif Chemokine 26 3
  • MIP-4alpha 3
  • MIP-4a 3
  • IMAC 3

External Ids for CCL26 Gene

Previous HGNC Symbols for CCL26 Gene

  • SCYA26

Previous GeneCards Identifiers for CCL26 Gene

  • GC07M073934
  • GC07M074997
  • GC07M075010
  • GC07M075043
  • GC07M075236
  • GC07M075398
  • GC07M070484

Summaries for CCL26 Gene

Entrez Gene Summary for CCL26 Gene

  • This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL26 Gene

CCL26 (C-C Motif Chemokine Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include Esophagitis and Tuberous Sclerosis-1. Among its related pathways are PEDF Induced Signaling and Akt Signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL18.

UniProtKB/Swiss-Prot for CCL26 Gene

  • Chemotactic for eosinophils and basophils. Binds to CCR3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL26 Gene

Genomics for CCL26 Gene

Regulatory Elements for CCL26 Gene

Enhancers for CCL26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F075949 1.5 FANTOM5 Ensembl ENCODE 11.7 -161.0 -161030 2.2 CTCF PKNOX1 SIN3A RAD21 YY1 ZNF316 GATA3 CTBP1 SCRT2 RCOR1 POR CCL26 SRRM3 MDH2 RHBDD2 GTF2IP1 TMEM120A GC07P075946 SNORA14A
GH07F075913 1.4 Ensembl ENCODE 11.6 -128.9 -128864 9.5 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 LOC100133091 RHBDD2 SNORA14A CCL26 POR ZP3 RPL7L1P3 MIR4651
GH07F075841 1.3 Ensembl ENCODE 11.9 -53.3 -53274 2.5 ATF1 FOS KDM4B KLF13 GTF2B JUNB REST TBX21 ZNF592 CREB3 LOC100133091 CCL26 POR MIR4651 SNORA14A NSUN5P1 CCL24 STAG3L1 SRRM3 RHBDD2
GH07F076104 1.4 Ensembl ENCODE 10.5 -317.6 -317617 5.1 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 YY1 STYXL1 MDH2 STAG3L1 SPDYE18 NSUN5P1 LOC100133091 ENSG00000230882 TRIM73 LOC100422695 SRRM3
GH07F075905 1.3 Ensembl ENCODE 11.2 -116.8 -116797 3.0 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GATA2 FOS SNORA14A CCL26 CCL24 SRRM3 UPK3B ZP3 MIR4651 POR RPL7L1P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL26 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL26 Gene

75,769,524 bp from pter
75,789,896 bp from pter
20,373 bases
Minus strand

Genomic View for CCL26 Gene

Genes around CCL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL26 Gene

Proteins for CCL26 Gene

  • Protein details for CCL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C motif chemokine 26
    Protein Accession:
    Secondary Accessions:
    • A0N0Q5
    • Q52LV8

    Protein attributes for CCL26 Gene

    94 amino acids
    Molecular mass:
    10648 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL26 Gene

neXtProt entry for CCL26 Gene

Post-translational modifications for CCL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL26 Gene

Antibody Products

  • R&D Systems Antibodies for CCL26 (CCL26/Eotaxin-3)

No data available for DME Specific Peptides for CCL26 Gene

Domains & Families for CCL26 Gene

Gene Families for CCL26 Gene

Protein Domains for CCL26 Gene

Suggested Antigen Peptide Sequences for CCL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine beta (chemokine CC) family.
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL26: view

Function for CCL26 Gene

Molecular function for CCL26 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for eosinophils and basophils. Binds to CCR3.

Gene Ontology (GO) - Molecular Function for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,TAS --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL26: view
genes like me logo Genes that share phenotypes with CCL26: view

Animal Model Products

miRNA for CCL26 Gene

miRTarBase miRNAs that target CCL26

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL26 Gene

Localization for CCL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL26 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL26 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with CCL26: view

Pathways & Interactions for CCL26 Gene

genes like me logo Genes that share pathways with CCL26: view

Pathways by source for CCL26 Gene

Interacting Proteins for CCL26 Gene

Selected Interacting proteins: Q9Y258-CCL26_HUMAN for CCL26 Gene via IID

Gene Ontology (GO) - Biological Process for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10373330
GO:0006954 inflammatory response IEA,TAS --
GO:0006955 immune response TAS 10373330
genes like me logo Genes that share ontologies with CCL26: view

No data available for SIGNOR curated interactions for CCL26 Gene

Drugs & Compounds for CCL26 Gene

(7) Drugs for CCL26 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CCL26 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL26: view

Transcripts for CCL26 Gene

Unigene Clusters for CCL26 Gene

Chemokine (C-C motif) ligand 26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL26 Gene

No ASD Table

Relevant External Links for CCL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCL26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL26 Gene

This gene is overexpressed in Ovary (x12.6), Nerve - Tibial (x5.7), and Pituitary (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL26 Gene:


SOURCE GeneReport for Unigene cluster for CCL26 Gene:


mRNA Expression by UniProt/SwissProt for CCL26 Gene:

Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.
genes like me logo Genes that share expression patterns with CCL26: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL26 Gene

Orthologs for CCL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCL26 34 35
  • 98.94 (n)
(Canis familiaris)
Mammalia CCL26 34 35
  • 76.7 (n)
(Bos Taurus)
Mammalia CCL26 34
  • 74.11 (n)
-- 35
  • 37 (a)
(Mus musculus)
Mammalia Ccl26 35
  • 49 (a)
(Gallus gallus)
Aves GGCL1 35
  • 34 (a)
(Danio rerio)
Actinopterygii ZGC:193706 35
  • 32 (a)
Species where no ortholog for CCL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCL26 Gene

Gene Tree for CCL26 (if available)
Gene Tree for CCL26 (if available)

Paralogs for CCL26 Gene

genes like me logo Genes that share paralogs with CCL26: view

Variants for CCL26 Gene

Sequence variations from dbSNP and Humsavar for CCL26 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10236263 -- 75,776,891(+) tatgc(A/G)cactc intron-variant
rs10236735 -- 75,777,211(+) tgcgc(A/G)gcaag intron-variant
rs10240646 -- 75,771,461(+) CACAC(C/T)TGTAA intron-variant
rs10243457 -- 75,780,269(+) ctacc(C/T)tatct intron-variant
rs10243921 -- 75,782,935(+) aggct(A/G)ctcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL26 Gene

Variant ID Type Subtype PubMed ID
nsv607516 CNV gain 21841781
nsv528969 CNV gain 19592680
nsv518028 CNV gain 19592680
esv3613739 CNV loss 21293372
esv3613738 CNV loss 21293372
esv3613737 CNV gain 21293372
esv3613726 CNV gain 21293372
esv2764051 CNV gain+loss 21179565
esv23585 CNV loss 19812545
dgv6468n100 CNV gain 25217958
dgv120n16 CNV deletion 17901297

Variation tolerance for CCL26 Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL26 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL26 Gene

Disorders for CCL26 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CCL26 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute esophagitis
tuberous sclerosis-1
  • tuberous sclerosis
heart tumor
  • intracavitary tumors
eosinophilic gastritis
  • eosinophilic gastritis [ambiguous]
esophagitis, eosinophilic, 1
  • eosinophilic esophagitis
- elite association - COSMIC cancer census association via MalaCards
Search CCL26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCL26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL26 Gene

Publications for CCL26 Gene

  1. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PMID: 10373330) Guo R.F. … Shi M.M. (Genomics 1999) 2 3 4 22 64
  2. [The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma]. (PMID: 16604488) Gao G.M. … He Z.Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006) 3 22 46 64
  3. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PMID: 16391516) Park Y.R. … Chung H.T. (Exp. Mol. Med. 2005) 3 22 46 64
  4. Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. (PMID: 15784470) Chae S.C. … Chung H.T. (Hum. Immunol. 2005) 3 22 46 64
  5. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PMID: 15207712) Chae S.C. … Chung H.T. (Biochem. Biophys. Res. Commun. 2004) 3 22 46 64

Products for CCL26 Gene

Sources for CCL26 Gene

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