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Aliases for CCL25 Gene

Aliases for CCL25 Gene

  • Chemokine (C-C Motif) Ligand 25 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25 2 3
  • Small-Inducible Cytokine A25 3 4
  • Thymus Expressed Chemokine 2 3
  • Thymus-Expressed Chemokine 3 4
  • Chemokine TECK 3 4
  • Ck Beta-15 2 3
  • TECKvar 2 3
  • SCYA25 3 4
  • TECK 3 4
  • Ckb15 3

External Ids for CCL25 Gene

Previous HGNC Symbols for CCL25 Gene

  • SCYA25

Previous GeneCards Identifiers for CCL25 Gene

  • GC19P008076
  • GC19P008222
  • GC19P008023
  • GC19P007788

Summaries for CCL25 Gene

Entrez Gene Summary for CCL25 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL25 Gene

CCL25 (Chemokine (C-C Motif) Ligand 25) is a Protein Coding gene. Diseases associated with CCL25 include intestinal disease. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include hormone activity and chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL25 Gene

  • Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL25 Gene

Genomics for CCL25 Gene

Genomic Location for CCL25 Gene

Chromosome:
19
Start:
8,052,340 bp from pter
End:
8,062,663 bp from pter
Size:
10,324 bases
Orientation:
Plus strand

Genomic View for CCL25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL25 Gene

Proteins for CCL25 Gene

  • Protein details for CCL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15444-CCL25_HUMAN
    Recommended name:
    C-C motif chemokine 25
    Protein Accession:
    O15444
    Secondary Accessions:
    • A1L4J4
    • A6NI52
    • A8K9E7
    • B5MCA5
    • Q96KJ7

    Protein attributes for CCL25 Gene

    Size:
    150 amino acids
    Molecular mass:
    16609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCL25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL25 Gene

Proteomics data for CCL25 Gene at MOPED

Post-translational modifications for CCL25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL25 Gene

Antibody Products

No data available for DME Specific Peptides for CCL25 Gene

Domains & Families for CCL25 Gene

Gene Families for CCL25 Gene

Protein Domains for CCL25 Gene

Graphical View of Domain Structure for InterPro Entry

O15444

UniProtKB/Swiss-Prot:

CCL25_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL25: view

Function for CCL25 Gene

Molecular function for CCL25 Gene

UniProtKB/Swiss-Prot Function:
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

Gene Ontology (GO) - Molecular Function for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 9285413
GO:0005515 protein binding --
GO:0008009 chemokine activity IDA 18308860
GO:0031735 CCR10 chemokine receptor binding IDA 10706668
GO:0042379 chemokine receptor binding IDA 23341447
genes like me logo Genes that share ontologies with CCL25: view
genes like me logo Genes that share phenotypes with CCL25: view

Animal Models for CCL25 Gene

MGI Knock Outs for CCL25:

Animal Model Products

CRISPR Products

miRNA for CCL25 Gene

miRTarBase miRNAs that target CCL25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL25

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCL25 Gene

Localization for CCL25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL25 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL25 Gene COMPARTMENTS Subcellular localization image for CCL25 gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL25: view

Pathways & Interactions for CCL25 Gene

genes like me logo Genes that share pathways with CCL25: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CCL25 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IDA 18308860
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10640743
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 10640743
genes like me logo Genes that share ontologies with CCL25: view

Drugs & Compounds for CCL25 Gene

(1) Drugs for CCL25 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(2) Additional Compounds for CCL25 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
RANTES
TECK
genes like me logo Genes that share compounds with CCL25: view

Transcripts for CCL25 Gene

Unigene Clusters for CCL25 Gene

Chemokine (C-C motif) ligand 25:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for CCL25 Gene

GeneLoc Exon Structure for
CCL25
ECgene alternative splicing isoforms for
CCL25

Expression for CCL25 Gene

mRNA expression in normal human tissues for CCL25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL25 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x46.4).

SOURCE GeneReport for Unigene cluster for CCL25 Gene Hs.310511

mRNA Expression by UniProt/SwissProt for CCL25 Gene

O15444-CCL25_HUMAN
Tissue specificity: Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine
genes like me logo Genes that share expression patterns with CCL25: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL25 Gene

Orthologs for CCL25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCL25 35
  • 69.2 (n)
  • 55.17 (a)
CCL25 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL25 35
  • 68.48 (n)
  • 47.62 (a)
CCL25 36
  • 46 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl25 35
  • 63.82 (n)
  • 54.26 (a)
Ccl25 16
Ccl25 36
  • 44 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCL25 35
  • 99.11 (n)
  • 98 (a)
CCL25 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl25 35
  • 62.16 (n)
  • 48.87 (a)
oppossum
(Monodelphis domestica)
Mammalia CCL25 36
  • 36 (a)
OneToOne
Species with no ortholog for CCL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL25 Gene

ENSEMBL:
Gene Tree for CCL25 (if available)
TreeFam:
Gene Tree for CCL25 (if available)

Paralogs for CCL25 Gene

(2) SIMAP similar genes for CCL25 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL25: view

No data available for Paralogs for CCL25 Gene

Variants for CCL25 Gene

Sequence variations from dbSNP and Humsavar for CCL25 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889316 -- 8,050,490(-) TGAGG(C/T)TGGAC upstream-variant-2KB
rs918638 -- 8,057,400(-) gtgag(A/T)tgtga intron-variant
rs960173 - 8,053,116(-) TTGGG(C/T)GTGGA reference, missense
rs1104768 -- 8,050,836(-) CGGGG(A/C)CGTGA upstream-variant-2KB
rs1129763 - 8,056,485(+) CAACA(C/T)GCAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCL25 Gene

Variant ID Type Subtype PubMed ID
nsv833734 CNV Loss 17160897
nsv910994 CNV Loss 21882294
nsv910995 CNV Loss 21882294
esv1497112 CNV Deletion 17803354

Variation tolerance for CCL25 Gene

Residual Variation Intolerance Score: 81.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL25 Gene

HapMap Linkage Disequilibrium report
CCL25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL25 Gene

Disorders for CCL25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCL25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal disease
  • intestinal diseases
- elite association
Search CCL25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL25

Genetic Association Database (GAD)
CCL25
Human Genome Epidemiology (HuGE) Navigator
CCL25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL25
genes like me logo Genes that share disorders with CCL25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL25 Gene

Publications for CCL25 Gene

  1. The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2. (PMID: 9722960) Nomiyama H. … Matsuda Y. (Genomics 1998) 2 23 67
  2. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. (PMID: 9285413) Vicari A.P. … Zlotnik A. (Immunity 1997) 2 23 67
  3. A differential cytokine expression profile is induced by highly purified human menopausal gonadotropin and recombinant follicle-stimulating hormone in a pre- and postovulatory mouse follicle culture model. (PMID: 19362302) Foster R. … Princivalle M. (Fertil. Steril. 2010) 23 67
  4. Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. (PMID: 20081876) Wang Y. … Li D. (Cell. Mol. Immunol. 2010) 23 67
  5. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. (PMID: 19525985) Inamoto Y. … Naoe T. (Bone Marrow Transplant. 2010) 23 67

Products for CCL25 Gene

Sources for CCL25 Gene

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