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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL25 Gene

protein-coding   GIFtS: 59
GCID: GC19P008117

Chemokine (C-C Motif) Ligand 25

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 25)
(Previous symbol: SCYA25)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 251 2     Thymus Expressed Chemokine1 2
SCYA251 2 3 5     Chemokine TECK2 3
TECK2 3 5     Small-Inducible Cytokine A252 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 251 2     Thymus-Expressed Chemokine2 3
TECKvar1 2     Ckb152
Ck Beta-151 2     C-C Motif Chemokine 252

External Ids:    HGNC: 106241   Entrez Gene: 63702   Ensembl: ENSG000001311427   OMIM: 6025655   UniProtKB: O154443   

Export aliases for CCL25 gene to outside databases

Previous GC identifers: GC19P008076 GC19P008222 GC19P008023 GC19P007788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL25 Gene:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins
involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two
adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells,
thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The
product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Feb 2011)

GeneCards Summary for CCL25 Gene: 
CCL25 (chemokine (C-C motif) ligand 25) is a protein-coding gene. Diseases associated with CCL25 include obstructive jaundice, and pulmonary sarcoidosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include hormone activity and CCR10 chemokine receptor binding.

UniProtKB/Swiss-Prot: CCL25_HUMAN, O15444
Function: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on
thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and
neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_077812.2  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL25 gene promoter:
         RFX1   HSF1 (long)   Lmo2   HNF-4alpha2   MIF-1   Evi-1   C/EBPalpha   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL25 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CCL25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL25 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008117:  view genomic region     (about GC identifiers)

Start:
8,117,646 bp from pter      End:
8,127,547 bp from pter
Size:
9,902 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL25_HUMAN, O15444 (See protein sequence)
Recommended Name: C-C motif chemokine 25 precursor  
Size: 150 amino acids; 16609 Da
Subcellular location: Secreted
Secondary accessions: A1L4J4 A6NI52 A8K9E7 B5MCA5 Q96KJ7
Alternative splicing: 3 isoforms:  O15444-1   O15444-2   O15444-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CCL25: NX_O15444

Explore proteomics data for CCL25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15444

  • CCL25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL25 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001188288.1  NP_005615.2  

    ENSEMBL proteins: 
     ENSP00000253451   ENSP00000375086   ENSP00000401882   ENSP00000324756  
    Reactome Protein details: O15444
    Human Recombinant Protein Products for CCL25: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL25
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCL25
    GenScript Purified and Recombinant Proteins for CCL25
    Novus Biologicals CCL25 Protein
    Novus Biologicals CCL25 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL25
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL25 for ontologies           About GeneDecksing



    CCL25 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL25 (CCL25/TECK)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL25
    GenScript Custom Superior Antibodies Services for CCL25
    Novus Biologicals CCL25 Antibodies
    Abcam antibodies for CCL25
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CCL25
    LSBio Antibodies in human, mouse, rat for CCL25 

    Assay Products for CCL25: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL25
    R&D Systems Flow Cytometry Kits for CCL25 (CCL25/TECK)         (see all)
    GenScript Custom Assay Services for CCL25
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    1 InterPro protein domain:
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O15444

    ProtoNet protein and cluster: O15444

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL25_HUMAN, O15444
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL25_HUMAN, O15444
    Function: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on
    thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and
    neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS9285413
    GO:0005515protein binding ----
    GO:0008009chemokine activity IEA--
    GO:0031735CCR10 chemokine receptor binding IDA10706668
         
    CCL25 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccl25):
     adipose tissue  digestive/alimentary  hematopoietic system  immune system 

    CCL25 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCL25: Ccl25tm1Mal Ccl25tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL25 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL25 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL25 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL25
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL25
    SwitchGear 3'UTR luciferase reporter plasmidCCL25 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL25
    Sirion Biotech Customized adenovirus for overexpression of CCL25

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL25 (see all 6)
    OriGene ORF clones in mouse, rat for CCL25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL25 (NM_001201359)
    Sino Biological Human cDNA Clone for CCL25
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL25
    Sirion Biotech Customized lentivirus for stable overexpression of CCL25 
                         Customized lentivirus expression plasmids for stable overexpression of CCL25 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCL25
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL25


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL25 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL25 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    5/8        Reactome Pathways for CCL25 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCL25):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCL25 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCL25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/155 Interacting proteins for CCL25 (O154442, 3 ENSP000003750864) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR4Q9NPB93, ENSP000002498874I2D: score=3 STRING: ENSP00000249887
    ACKR2O005903, ENSP000002731454I2D: score=2 STRING: ENSP00000273145
    CCR10P460923, ENSP000003325044I2D: score=2 STRING: ENSP00000332504
    CCR9P516863, ENSP000003502564I2D: score=2 STRING: ENSP00000350256
    ACKR3ENSP000002729284STRING: ENSP00000272928
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007166cell surface receptor signaling pathway TAS10640743
    GO:0007186G-protein coupled receptor signaling pathway TAS10544196

    CCL25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL25 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL25

    3 Novoseek inferred chemical compound relationships for CCL25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 99.2 101 15833102 (8), 9285413 (8), 10229797 (6), 11487533 (6) (see all 33)
    rantes 39.3 2 10449163 (1), 17925465 (1)
    calcium 0 4 10640743 (1), 10498628 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL25 gene (3 alternative transcripts): 
    NM_001201359.1  NM_005624.3  NM_148888.1  

    Unigene Cluster for CCL25:

    Chemokine (C-C motif) ligand 25
    Hs.310511  [show with all ESTs]
    Unigene Representative Sequence: NM_005624
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253451(uc002mjd.3 uc002mjc.4) ENST00000390669(uc010dvy.1)
    ENST00000458625 ENST00000315626
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL25
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL25
    SwitchGear 3'UTR luciferase reporter plasmidCCL25 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL25
    Clone
    Products:
         
    OriGene clones in human, mouse for CCL25 (see all 6)
    OriGene ORF clones in mouse, rat for CCL25
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCL25 (NM_001201359)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL25
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                         Customized lentivirus expression plasmids for stable overexpression of CCL25 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL25
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL25

    Additional mRNA sequence: 

    AB046579.1 AK292662.1 BC125136.1 BC130561.1 BC144463.1 U86358.1 

    1 DOTS entry:

    DT.98131785 

    19 AceView cDNA sequences:

    AA295814 CR603063 NM_148888 NM_005624 AB046579 AI091662 AW393076 AA295945 
    BX106823 BX415301 AI185600 U86358 AA295925 AI313430 BX415300 AI961745 
    N73958 AA295958 AI313153 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL25    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for CCL25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL25 expression in normal human tissues (normalized intensities)      CCL25 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTAAAGAA
    CCL25 Expression
    About this image


    CCL25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 5 entries
             ileum   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Thymus
             Thymus   

    See CCL25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL25

    SOURCE GeneReport for Unigene cluster: Hs.310511

    UniProtKB/Swiss-Prot: CCL25_HUMAN, O15444
    Tissue specificity: Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL25: 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCL25
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL25 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl251 , 5 chemokine (C-C motif) ligand 251, 5 63.82(n)1
    54.26(a)1
      8 (2.01 cM)5
    203001  NM_009138.31  NP_033164.11 
     43252105 
    zebrafish
    (Danio rerio)
    Actinopterygii CU693369.16
    ccl25b6
    chemokine (C-C motif) ligand 25b
    33(a)
    32(a)
    many → 1
    many → 1
    2(54170996-54179310)
    11(6296249-6300131)


    ENSEMBL Gene Tree for CCL25 (if available)
    TreeFam Gene Tree for CCL25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL25 gene
    2 SIMAP similar genes for CCL25 using alignment to 3 protein entries:     CCL25_HUMAN (see all proteins):
    CCL26    CCL5

    CCL25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in CCL25 are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160446101,2
    F--8115657(+) GCCCAT/AAGCCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1869610391,2
    --8115702(+) TAAGTA/GTCATT 2 -- us2k10--------
    rs31366491,2
    H--8115711(+) TTTATC/TTAGTC 2 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs11047681,2
    C,F,H--8115720(-) CGGGGA/CCGTGA 2 -- us2k123Minor allele frequency- N:0.00NS EA NA CSA WA 2558
    rs11098921,2
    H--8115761(-) GCTTAG/CAGGTG 2 -- us2k15Minor allele frequency- C:0.00NS EA NA 408
    rs1902511001,2
    --8115878(+) AAATAA/CCCACA 2 -- us2k10--------
    rs1130744611,2
    C,F--8115893(+) TCAGAT/GGTAGC 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs1814988831,2
    --8115987(+) CGTGTC/TTCCCC 2 -- us2k10--------
    rs1866539581,2
    --8116048(+) CCTTCG/TCCCAT 2 -- us2k10--------
    rs1114660691,2
    F--8116077(+) ACCCCG/CTCTCT 2 -- us2k11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for CCL25 (8117646 - 8127547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCL25:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1497112CNV Deletion17803354
    nsv910994CNV Loss21882294
    nsv833734CNV Loss17160897
    nsv910995CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602565    OMIM disorders: --

    20/31 diseases for CCL25 (see all 31):    About MalaCards
    obstructive jaundice    pulmonary sarcoidosis    allergic asthma    acute graft versus host disease
    jaundice    cystadenoma    graft versus host disease    sarcoidosis
    sclerosing cholangitis    cholangitis    bronchiolitis    crohn's disease
    inflammatory bowel disease    gastritis    endometriosis    chronic lymphocytic leukemia
    asthma    obesity    multiple myeloma    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for CCL25:
    Inflammatory bowel disease

    CCL25 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for CCL25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 41.6 2 15492285 (2)
    inflammation 25.6 4 17101325 (2), 14557062 (1), 15306587 (1)
    inflammatory bowel diseases 20.2 1 19233184 (1)
    metastasis 0 1 15086554 (1)
    tumors 0 2 15492285 (1), 18245522 (1)

    Genetic Association Database (GAD): CCL25
    Human Genome Epidemiology (HuGE) Navigator: CCL25 (7 documents)

    Export disorders for CCL25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL25 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with CCL25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. (PubMed id 9285413)1, 2, 3, 9 Vicari A.P....Zlotnik A. (1997)
    2. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PubMed id 10229797)1, 2, 9 Zaballos A.... Marquez G. (1999)
    3. The human CC chemokine TECK (SCYA25) maps to chromoso me 19p13.2. (PubMed id 9722960)1, 3, 9 Nomiyama H....Matsuda Y. (1998)
    4. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    6. Abnormal regulation of chemokine TECK and its recepto r CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. (PubMed id 20081876)1, 9 Wang Y....Li D. (2010)
    7. Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC). (PubMed id 19003934)1, 9 Sundstrom P....Quiding-Jarbrink M. (2008)
    8. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta- 15 that differ in their sensitivities to ligand. (PubMed id 10640743)1, 9 Yu C.-R.... Farber J.M. (2000)
    9. Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1. (PubMed id 17510295)1, 9 Parmo-Cabanas M....Teixido J. (2007)
    10. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. (PubMed id 11046037)1, 9 Papadakis K.A....Targan S.R. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6370 HGNC: 10624 AceView: CCL25 Ensembl:ENSG00000131142 euGenes: HUgn6370
    ECgene: CCL25 Kegg: 6370 H-InvDB: CCL25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL25 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL25

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL25 gene:
    Search GeneIP for patents involving CCL25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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