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Aliases for CCL24 Gene

Aliases for CCL24 Gene

  • C-C Motif Chemokine Ligand 24 2 3
  • Myeloid Progenitor Inhibitory Factor 2 2 3 4
  • Chemokine (C-C Motif) Ligand 24 2 3 5
  • CK-Beta-6 2 3 4
  • Eotaxin-2 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24 2 3
  • Eosinophil Chemotactic Protein 2 3 4
  • Small-Inducible Cytokine A24 3 4
  • SCYA24 3 4
  • MPIF-2 3 4
  • MPIF2 3 4
  • Ckb-6 3

External Ids for CCL24 Gene

Previous HGNC Symbols for CCL24 Gene

  • SCYA24

Previous GeneCards Identifiers for CCL24 Gene

  • GC07M073976
  • GC07M075039
  • GC07M075053
  • GC07M075085
  • GC07M075279
  • GC07M075440
  • GC07M070527

Summaries for CCL24 Gene

Entrez Gene Summary for CCL24 Gene

  • This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL24 Gene

CCL24 (C-C Motif Chemokine Ligand 24) is a Protein Coding gene. Diseases associated with CCL24 include eosinophilia and allergic asthma. Among its related pathways are Chemokine Signaling and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL24 Gene

  • Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL24 Gene

Genomics for CCL24 Gene

Regulatory Elements for CCL24 Gene

Enhancers for CCL24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL24 Gene

Chromosome:
7
Start:
75,811,429 bp from pter
End:
75,823,356 bp from pter
Size:
11,928 bases
Orientation:
Minus strand

Genomic View for CCL24 Gene

Genes around CCL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL24 Gene

Proteins for CCL24 Gene

  • Protein details for CCL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00175-CCL24_HUMAN
    Recommended name:
    C-C motif chemokine 24
    Protein Accession:
    O00175
    Secondary Accessions:
    • B2R5K2

    Protein attributes for CCL24 Gene

    Size:
    119 amino acids
    Molecular mass:
    13134 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL24 Gene

neXtProt entry for CCL24 Gene

Proteomics data for CCL24 Gene at MOPED

Post-translational modifications for CCL24 Gene

Other Protein References for CCL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL24 (CCL24/Eotaxin-2/MPIF-2)

No data available for DME Specific Peptides for CCL24 Gene

Domains & Families for CCL24 Gene

Gene Families for CCL24 Gene

Protein Domains for CCL24 Gene

Suggested Antigen Peptide Sequences for CCL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00175

UniProtKB/Swiss-Prot:

CCL24_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL24: view

Function for CCL24 Gene

Molecular function for CCL24 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
genes like me logo Genes that share phenotypes with CCL24: view

Animal Models for CCL24 Gene

MGI Knock Outs for CCL24:

Animal Model Products

miRNA for CCL24 Gene

miRTarBase miRNAs that target CCL24

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL24 Gene

Localization for CCL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL24 Gene COMPARTMENTS Subcellular localization image for CCL24 gene
Compartment Confidence
extracellular 4

No data available for Gene Ontology (GO) - Cellular Components for CCL24 Gene

Pathways & Interactions for CCL24 Gene

genes like me logo Genes that share pathways with CCL24: view

Interacting Proteins for CCL24 Gene

Selected Interacting proteins: O00175-CCL24_HUMAN for CCL24 Gene via I2D

Symbol External ID(s) Details
CCR3

Gene Ontology (GO) - Biological Process for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA,TAS 9104803
GO:0006955 immune response IEA,TAS 10713092
GO:0007010 cytoskeleton organization IDA 10072545
genes like me logo Genes that share ontologies with CCL24: view

No data available for SIGNOR curated interactions for CCL24 Gene

Drugs & Compounds for CCL24 Gene

(3) Drugs for CCL24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CCL24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL24: view

Transcripts for CCL24 Gene

mRNA/cDNA for CCL24 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL24 Gene

Chemokine (C-C motif) ligand 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL24 Gene

No ASD Table

Relevant External Links for CCL24 Gene

GeneLoc Exon Structure for
CCL24
ECgene alternative splicing isoforms for
CCL24

Expression for CCL24 Gene

mRNA expression in normal human tissues for CCL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL24 Gene

This gene is overexpressed in Spleen (x30.9), Small Intestine - Terminal Ileum (x9.9), and Colon - Transverse (x4.1).

SOURCE GeneReport for Unigene cluster for CCL24 Gene Hs.247838

mRNA Expression by UniProt/SwissProt for CCL24 Gene

O00175-CCL24_HUMAN
Tissue specificity: Activated monocytes and activated T lymphocytes.
genes like me logo Genes that share expression patterns with CCL24: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL24 Gene

Orthologs for CCL24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCL24 35
  • 75.15 (n)
  • 62.28 (a)
CCL24 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL24 35
  • 74.58 (n)
  • 62.71 (a)
CCL24 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl24 35
  • 71.51 (n)
  • 58.97 (a)
Ccl24 16
Ccl24 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCL24 35
  • 98.59 (n)
  • 98.31 (a)
CCL24 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl24 35
  • 68.66 (n)
  • 56.41 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 14 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
Species with no ortholog for CCL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL24 Gene

ENSEMBL:
Gene Tree for CCL24 (if available)
TreeFam:
Gene Tree for CCL24 (if available)

Paralogs for CCL24 Gene

Paralogs for CCL24 Gene

(23) SIMAP similar genes for CCL24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL24: view

Variants for CCL24 Gene

Sequence variations from dbSNP and Humsavar for CCL24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2302006 - 75,813,412(-) TGGTC(A/C)TCCCC reference, missense
rs11465293 - 75,813,405(-) CCCCT(C/T)TCCCT reference, missense
rs11465312 - 75,811,852(-) CCAGG(A/G)CAGTG reference, missense
rs11465313 - 75,811,828(-) CTGTC(C/G)AGAGA reference, missense
rs873972 -- 75,815,231(-) CTCCC(A/G)AGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL24 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
nsv518028 CNV Gain 19592680

Variation tolerance for CCL24 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.31; 70.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL24 Gene

HapMap Linkage Disequilibrium report
CCL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL24 Gene

Disorders for CCL24 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL24 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilia
  • eosinophil count raised
allergic asthma
  • atopic asthma
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search CCL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL24

Genetic Association Database (GAD)
CCL24
Human Genome Epidemiology (HuGE) Navigator
CCL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL24
genes like me logo Genes that share disorders with CCL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL24 Gene

Publications for CCL24 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel V.P. … Garotta G. (J. Exp. Med. 1997) 2 3 4 23 67
  2. Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23. (PMID: 9598329) Nomiyama H. … Yoshie O. (Genomics 1998) 2 3 23
  3. Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. (PMID: 20236835) Owczarek W. … Kasztalewicz B. (Cytokine 2010) 3 23
  4. [Effects of corticosteroid on Eotaxin and Eotaxin-2 in nasal polyps]. (PMID: 19522186) Wang X. … Gong S. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009) 3 23
  5. Ontogeny of the eotaxins in human lung. (PMID: 18055844) Haley K.J. … Lilly C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008) 3 23

Products for CCL24 Gene

Sources for CCL24 Gene

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