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CCL24 Gene

protein-coding   GIFtS: 57
GCID: GC07M075440

Chemokine (C-C Motif) Ligand 24

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 24)
(Previous symbol: SCYA24)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 241 2     Eosinophil Chemotactic Protein 22 3
SCYA241 2 3 5     Small-Inducible Cytokine A242 3
CK-beta-61 2 3     MPIF-22 3
Myeloid Progenitor Inhibitory Factor 21 2 3     Ckb-62
MPIF22 3 5     C-C Motif Chemokine 242
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 241 2     Eotaxin-23
eotaxin-21 2     

External Ids:    HGNC: 106231   Entrez Gene: 63692   Ensembl: ENSG000001061787   OMIM: 6024955   UniProtKB: O001753   

Export aliases for CCL24 gene to outside databases

Previous GC identifers: GC07M073976 GC07M075039 GC07M075053 GC07M075085 GC07M075279 GC07M070527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL24 Gene:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins
involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two
adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a
minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a
strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCL24 Gene:
CCL24 (chemokine (C-C motif) ligand 24) is a protein-coding gene. Diseases associated with CCL24 include papillary conjunctivitis, and giant papillary conjunctivitis. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL24_HUMAN, O00175
Function: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils
but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential
hematopoietic progenitor cell line. Binds to CCR3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL24 gene promoter:
         TBP   STAT5B   AP-1   IRF-1   NF-AT   NF-AT4   NF-AT2   NF-AT3   Hlf   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL24 promoter sequence
   Search Chromatin IP Primers for CCL24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

CCL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075440:  view genomic region     (about GC identifiers)

Start:
75,440,983 bp from pter      End:
75,452,674 bp from pter
Size:
11,692 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,774,178-74,776,097     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL24_HUMAN, O00175 (See protein sequence)
Recommended Name: C-C motif chemokine 24 precursor  
Size: 119 amino acids; 13134 Da
2 PDB 3D structures from and Proteopedia for CCL24:
1EIG (3D)        1EIH (3D)    
Secondary accessions: B2R5K2

Explore the universe of human proteins at neXtProt for CCL24: NX_O00175

Explore proteomics data for CCL24 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn115

  • See CCL24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002982.2  
    ENSEMBL proteins: 
     ENSP00000222902   ENSP00000400533  

    CCL24 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CCL24
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL24
    GenScript Purified and Recombinant Proteins for CCL24
    Novus Biologicals CCL24 Proteins
    Novus Biologicals CCL24 Lysates
    Sino Biological Recombinant Protein for CCL24
    Sino Biological Cell Lysate for CCL24
    ProSpec Recombinant Protein for CCL24
    Browse Proteins at Cloud-Clone Corp.

    CCL24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CCL24 Antibodies
    Abcam antibodies for CCL24
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL24
    LSBio Antibodies in human, mouse, rat for CCL24

    CCL24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CCL24
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    1 InterPro protein domain:
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O00175

    ProtoNet protein and cluster: O00175

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL24_HUMAN, O00175
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL24_HUMAN, O00175
    Function: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils
    but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential
    hematopoietic progenitor cell line. Binds to CCR3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0008009chemokine activity IDA10072545
         
    CCL24 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl24):
     hematopoietic system  immune system  respiratory system 

    CCL24 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl24tm1Mer for CCL24

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL24
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL24
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL24

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL24:
    hsa-mir-335-5p (MIRT017589)

    Block miRNA regulation of human, mouse, rat CCL24 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCL24
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL24
    Predesigned siRNA for gene silencing in human, mouse, rat CCL24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL24

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL24 (see all 5)
    OriGene ORF clones in mouse, rat for CCL24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL24 (NM_002991)
    Sino Biological Human cDNA Clone for CCL24
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL24

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL24
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL24_HUMAN, O00175: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CCL24 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL24 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL24
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL24 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL24
        Immune response CCR3 signaling in eosinophils



    2 Kegg Pathways  (Kegg details for CCL24):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL24 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL24 (see all 6): 
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CCL24 (O001753 ENSP000002229024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR4ENSP000003326594STRING: ENSP00000332659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19525930
    GO:0006935chemotaxis TAS9104803
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007010cytoskeleton organization IDA10072545

    CCL24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL24

    9 Novoseek inferred chemical compound relationships for CCL24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 84.7 54 10570327 (4), 11306977 (3), 11467997 (3), 11286614 (3) (see all 29)
    tarc 67.3 4 9794440 (1), 15591886 (1), 11964742 (1)
    ccl3 42.2 2 17350279 (1)
    calcium 13.2 13 10069890 (2), 11237428 (2), 9365122 (1), 9692884 (1) (see all 5)
    actinomycin d 10.1 1 15863444 (1)
    histamine 2.9 1 9182688 (1)
    oxygen 0 7 9692884 (4), 12784909 (1), 11286614 (1)
    steroid 0 1 19522186 (1)
    superoxide 0 1 12192108 (1)



    CCL24 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCL24 gene: 
    NM_002991.2  

    Unigene Cluster for CCL24:

    Chemokine (C-C motif) ligand 24
    Hs.247838  [show with all ESTs]
    Unigene Representative Sequence: BP338501
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222902(uc011kga.2) ENST00000416943
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL24 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCL24
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCL24
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    OriGene clones in human, mouse for CCL24 (see all 5)
    OriGene ORF clones in mouse, rat for CCL24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL24 (NM_002991)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL24
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL24
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL24
      QuantiTect SYBR Green Assays in human, mouse, rat CCL24
      QuantiFast Probe-based Assays in human, mouse, rat CCL24

    Additional mRNA sequence: 

    AJ223461.1 AK312216.1 BC069072.1 BC069391.1 U85768.1 

    1 DOTS entry:

    DT.91821775 

    8 AceView cDNA sequences:

    AJ223461 BP338501 BC069391 NM_002991 BC069072 BP338653 CB141759 U85768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCL24 Expression
    About this image


    CCL24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CCL24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247838

    UniProtKB/Swiss-Prot: CCL24_HUMAN, O00175
    Tissue specificity: Activated monocytes and activated T lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL24 (see all 6): 
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL24
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL24
    QuantiTect SYBR Green Assays in human, mouse, rat CCL24
    QuantiFast Probe-based Assays in human, mouse, rat CCL24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL24 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl241 , 5 chemokine (C-C motif) ligand 241, 5 71.51(n)1
    58.97(a)1
      5 (75.28 cM)5
    562211  NM_019577.41  NP_062523.11 
     1355699375 


    ENSEMBL Gene Tree for CCL24 (if available)
    TreeFam Gene Tree for CCL24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL24 gene
    CCL112  CCL132  CCL72  CCL82  CCL22  
    Selected SIMAP similar genes for CCL24 using alignment to 1 protein entry:     CCL24_HUMAN(see all similar genes):
    CCL5    CCL14    CCL3L1    CCL3L3    CCL18    CCL23
    CCL3    CCL4    CCL11    CCL4L2    LOC728835    CCL26
    CCL4L1    CCL13    CCL15    CCL2    CCL7    MCP-3

    CCL24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL24 (see all 148)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283743871,2
    C,F--75440666(+) GTGGTG/ACACAC 1 -- ds50014Minor allele frequency- A:0.50NA WA 8
    rs607776061,2
    C,F--75440704(+) AGGCAT/CGAGAA 1 -- ds50012Minor allele frequency- C:0.33NA CSA 3
    rs763645451,2
    C--75440752(+) AGATTG/TTGCCA 1 -- ds50010--------
    rs1384667061,2
    C--75440784(+) AGAGCA/GAGACT 1 -- ds50010--------
    rs1492822031,2
    --75440831(+) AACCAA/GGTCAG 1 -- ds50010--------
    rs1434965951,2
    --75440859(+) TTGCCA/CCTGCT 1 -- ds50010--------
    rs114653181,2
    C,F,H--75440876(-) GAAGAT/ACCCAG 1 -- ds50018Minor allele frequency- A:0.02NA EU NS EA 632
    rs1808301101,2
    --75440908(+) AGGGGC/GCTTGG 1 -- ds50010--------
    rs114653171,2
    C,F,H--75440940(-) GTTCCC/TGGGGG 1 -- ds50018Minor allele frequency- T:0.01NA EU NS EA WA 624
    rs1169106671,2
    F--75440977(+) CATAGA/GAGAGA 1 -- ds50011Minor allele frequency- G:0.01EA 120

    HapMap Linkage Disequilibrium report for CCL24 (75440983 - 75452674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCL24:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv120n16CNV Deletion17901297
    nsv528969CNV Gain19592680
    nsv518028CNV Gain19592680
    essv14753CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCL24
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602495    OMIM disorders: --

    Selected diseases for CCL24 (see all 40):    
    About MalaCards
    papillary conjunctivitis    giant papillary conjunctivitis    eosinophilic meningitis    angiostrongyliasis
    eosinophilic esophagitis    vernal keratoconjunctivitis    keratoconjunctivitis    allergic rhinitis
    conjunctivitis    eosinophilia    allergic asthma    rhinitis
    age related macular degeneration    acute promyelocytic leukemia    aspergillosis    rabies
    meningitis    ulcerative colitis    pertussis    tonsillitis

    1 disease from the University of Copenhagen DISEASES database for CCL24:
    Asthma

    CCL24 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCL24 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal polyps 64.6 23 19522186 (6), 17438849 (3), 11141953 (2), 16792175 (2) (see all 7)
    eosinophilia 64.3 13 15805998 (2), 15947325 (1), 10415058 (1), 10491000 (1) (see all 6)
    keratoconjunctivitis vernal 62.4 1 12623809 (1)
    asthma 59.5 18 16304252 (3), 17079258 (3), 15207712 (2), 15744457 (2) (see all 10)
    inflammation 55.4 14 16620281 (1), 15805998 (1), 10415058 (1), 12784909 (1) (see all 12)
    airways disease 46.8 5 14698143 (1), 15695929 (1), 19038554 (1)
    allergic reaction 38.4 4 10491000 (1), 12193745 (1), 15480317 (1)
    asthma allergic 37.5 1 19552640 (1)
    polyps 30.1 8 17438849 (4), 11141953 (2), 16792175 (1), 16682802 (1)
    colitis ulcerative 26.3 3 16391516 (2), 11346206 (1)

    Genetic Association Database (GAD): CCL24
    Human Genome Epidemiology (HuGE) Navigator: CCL24 (19 documents)

    Export disorders for CCL24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL24 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with CCL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PubMed id 9104803)1, 2, 3, 9 Patel V.P.... Garotta G. (J. Exp. Med. 1997)
    2. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. (PubMed id 9365122)1, 2, 9 White J.R....Sarau H.M. (J. Leukoc. Biol. 1997)
    3. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PubMed id 16391516)1, 4, 9 Park Y.R....Chung H.T. (amp 2005)
    4. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. (PubMed id 15580493)1, 4, 9 Chae S.C....Chung H.T. (Immunogenetics 2005)
    5. NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2. (PubMed id 10913244)1, 2, 9 Mayer K.L. and Stone M.J. (Biochemistry 2000)
    6. Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23. (PubMed id 9598329)1, 3, 9 Nomiyama H....Yoshie O. (Genomics 1998)
    7. Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration. (PubMed id 15744457)1, 4, 9 Min J.W....Shin H.D. (J. Hum. Genet. 2005)
    8. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PubMed id 15207712)1, 4, 9 Chae S.C....Chung H.T. (Biochem. Biophys. Res. Commun. 2004)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6369 HGNC: 10623 AceView: CCL24 Ensembl:ENSG00000106178 euGenes: HUgn6369
    ECgene: CCL24 Kegg: 6369 H-InvDB: CCL24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL24 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL24

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL24 gene:
    Search GeneIP for patents involving CCL24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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