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Aliases for CCL24 Gene

Aliases for CCL24 Gene

  • C-C Motif Chemokine Ligand 24 2 3 5
  • Myeloid Progenitor Inhibitory Factor 2 2 3 4
  • CK-Beta-6 2 3 4
  • Eotaxin-2 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24 2 3
  • Eosinophil Chemotactic Protein 2 3 4
  • Chemokine (C-C Motif) Ligand 24 2 3
  • Small-Inducible Cytokine A24 3 4
  • SCYA24 3 4
  • MPIF-2 3 4
  • MPIF2 3 4
  • C-C Motif Chemokine 24 3
  • Ckb-6 3

External Ids for CCL24 Gene

Previous HGNC Symbols for CCL24 Gene

  • SCYA24

Previous GeneCards Identifiers for CCL24 Gene

  • GC07M073976
  • GC07M075039
  • GC07M075053
  • GC07M075085
  • GC07M075279
  • GC07M075440
  • GC07M070527

Summaries for CCL24 Gene

Entrez Gene Summary for CCL24 Gene

  • This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL24 Gene

CCL24 (C-C Motif Chemokine Ligand 24) is a Protein Coding gene. Diseases associated with CCL24 include Allergic Asthma and Allergic Hypersensitivity Disease. Among its related pathways are PEDF Induced Signaling and fMLP Pathway. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL13.

UniProtKB/Swiss-Prot for CCL24 Gene

  • Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL24 Gene

Genomics for CCL24 Gene

Regulatory Elements for CCL24 Gene

Enhancers for CCL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G075866 1.3 Ensembl ENCODE 16.3 -43.4 -43365 1.4 HDGF PKNOX1 ATF1 CREB3L1 ARNT ARID4B SIN3A TCF12 ZNF143 NCOA1 CCL24 LOC100129130 ZP3 STYXL1 RHBDD2 POR
GH07G075964 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -144.2 -144189 5.4 HDAC1 GATA2 ZNF366 ETV6 FOS CREM JUNB USF2 ZEB2 REST STYXL1 POR SNORA14A CCL24 SRRM3 ENSG00000230882 MDH2 ZP3 GC07P075946 TMEM120A
GH07G076008 1.6 Ensembl ENCODE dbSUPER 11.3 -187.3 -187295 4.6 SIN3A ZNF2 ZBTB7B ZNF766 ZNF207 ZNF263 REST TBX21 SMARCA4 GLIS1 STYXL1 STAG3L1 NSUN5P1 DTX2P1 MDH2 ENSG00000230882 SNORA14A POR RHBDD2 CCL24
GH07G076068 1.1 Ensembl ENCODE 15.2 -246.1 -246136 1.5 PKNOX1 RB1 NFIB TBL1XR1 SIN3A NFXL1 RAD21 ZNF121 SCRT2 RCOR1 STYXL1 MDH2 CCL24 ENSG00000230882 SRRM3 LOC541473 PIR44690 GC07M076128 PIR46411
GH07G075953 1.5 Ensembl ENCODE dbSUPER 10.7 -135.4 -135404 10.7 PKNOX1 FOXA2 MLX ARID4B DMAP1 GATA2 FOS PAF1 REST PPARG POR ZP3 CCL26 RHBDD2 CCL24 SRRM3 ENSG00000230882 UPK3B MDH2 GTF2IP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL24 Gene

Chromosome:
7
Start:
75,811,429 bp from pter
End:
75,823,356 bp from pter
Size:
11,928 bases
Orientation:
Minus strand

Genomic View for CCL24 Gene

Genes around CCL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL24 Gene

Proteins for CCL24 Gene

  • Protein details for CCL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00175-CCL24_HUMAN
    Recommended name:
    C-C motif chemokine 24
    Protein Accession:
    O00175
    Secondary Accessions:
    • B2R5K2

    Protein attributes for CCL24 Gene

    Size:
    119 amino acids
    Molecular mass:
    13134 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL24 Gene

neXtProt entry for CCL24 Gene

Post-translational modifications for CCL24 Gene

Other Protein References for CCL24 Gene

Antibody Products

  • R&D Systems Antibodies for CCL24 (CCL24/Eotaxin-2/MPIF-2)

Assay Products

No data available for DME Specific Peptides for CCL24 Gene

Domains & Families for CCL24 Gene

Gene Families for CCL24 Gene

Protein Domains for CCL24 Gene

Suggested Antigen Peptide Sequences for CCL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00175

UniProtKB/Swiss-Prot:

CCL24_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL24: view

Function for CCL24 Gene

Molecular function for CCL24 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

Gene Ontology (GO) - Molecular Function for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,IDA 10072545
GO:0031728 CCR3 chemokine receptor binding IDA 11425309
GO:0048018 receptor agonist activity IDA 11425309
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL24: view
genes like me logo Genes that share phenotypes with CCL24: view

Animal Models for CCL24 Gene

MGI Knock Outs for CCL24:

Animal Model Products

CRISPR Products

miRNA for CCL24 Gene

miRTarBase miRNAs that target CCL24

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL24 Gene

Localization for CCL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL24 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL24: view

Pathways & Interactions for CCL24 Gene

genes like me logo Genes that share pathways with CCL24: view

Gene Ontology (GO) - Biological Process for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS,IEA 9104803
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS,IEA 10713092
genes like me logo Genes that share ontologies with CCL24: view

No data available for SIGNOR curated interactions for CCL24 Gene

Drugs & Compounds for CCL24 Gene

(5) Drugs for CCL24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CCL24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL24: view

Transcripts for CCL24 Gene

mRNA/cDNA for CCL24 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL24 Gene

Chemokine (C-C motif) ligand 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL24 Gene

No ASD Table

Relevant External Links for CCL24 Gene

GeneLoc Exon Structure for
CCL24
ECgene alternative splicing isoforms for
CCL24

Expression for CCL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL24 Gene

This gene is overexpressed in Spleen (x30.9), Small Intestine - Terminal Ileum (x9.9), and Colon - Transverse (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL24 Gene:

CCL24

SOURCE GeneReport for Unigene cluster for CCL24 Gene:

Hs.247838

mRNA Expression by UniProt/SwissProt for CCL24 Gene:

O00175-CCL24_HUMAN
Tissue specificity: Activated monocytes and activated T lymphocytes.

Evidence on tissue expression from TISSUES for CCL24 Gene

  • Blood(4.5)
  • Intestine(4.4)
  • Lung(2.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCL24: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL24 Gene

Orthologs for CCL24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL24 34 35
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia CCL24 34 35
  • 75.15 (n)
dog
(Canis familiaris)
Mammalia CCL24 34 35
  • 74.58 (n)
mouse
(Mus musculus)
Mammalia Ccl24 34 16 35
  • 71.51 (n)
rat
(Rattus norvegicus)
Mammalia Ccl24 34
  • 68.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 37 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
Species where no ortholog for CCL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL24 Gene

ENSEMBL:
Gene Tree for CCL24 (if available)
TreeFam:
Gene Tree for CCL24 (if available)

Paralogs for CCL24 Gene

(23) SIMAP similar genes for CCL24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL24: view

Variants for CCL24 Gene

Sequence variations from dbSNP and Humsavar for CCL24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000476293 -- 75,817,012(+) GGTGC(A/C)CGCCA intron-variant, upstream-variant-2KB
rs1000925298 -- 75,811,723(+) CACTG(C/T)GGCTT downstream-variant-500B, utr-variant-3-prime
rs1001847344 -- 75,813,110(+) CTCCT(A/G)AAAAG intron-variant
rs1001922285 -- 75,812,861(+) GGAGG(C/T)GGAGG intron-variant
rs1002204825 -- 75,823,915(+) AGAGT(C/T)TTGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL24 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv2764051 CNV gain+loss 21179565
esv3571926 CNV loss 25503493
nsv1134897 CNV tandem duplication 24896259
nsv518028 CNV gain 19592680
nsv528969 CNV gain 19592680

Variation tolerance for CCL24 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.31; 70.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL24 Gene

Disorders for CCL24 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CCL24 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic asthma
  • atopic asthma
allergic hypersensitivity disease
  • allergic disease
eosinophilic gastritis
  • eosinophilic enteropathy
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search CCL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL24

Genetic Association Database (GAD)
CCL24
Human Genome Epidemiology (HuGE) Navigator
CCL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL24
genes like me logo Genes that share disorders with CCL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL24 Gene

Publications for CCL24 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel V.P. … Garotta G. (J. Exp. Med. 1997) 2 3 4 22 64
  2. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. (PMID: 15580493) Chae S.C. … Chung H.T. (Immunogenetics 2005) 3 22 46 64
  3. Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration. (PMID: 15744457) Min J.W. … Shin H.D. (J. Hum. Genet. 2005) 3 22 46 64
  4. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PMID: 16391516) Park Y.R. … Chung H.T. (Exp. Mol. Med. 2005) 3 22 46 64
  5. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PMID: 15207712) Chae S.C. … Chung H.T. (Biochem. Biophys. Res. Commun. 2004) 3 22 46 64

Products for CCL24 Gene

Sources for CCL24 Gene

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