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Aliases for CCL23 Gene

Aliases for CCL23 Gene

  • C-C Motif Chemokine Ligand 23 2 3
  • Chemokine (C-C Motif) Ligand 23 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23 2 3
  • Myeloid Progenitor Inhibitory Factor 1 3 4
  • Macrophage Inflammatory Protein 3 3 4
  • CK-BETA-8 3 4
  • SCYA23 3 4
  • MPIF-1 3 4
  • Ckb-8 3 4
  • MIP-3 3 4
  • MIP3 3 4
  • Small-Inducible Cytokine A23 4
  • C6 Beta-Chemokine 3
  • Ckb-8-1 3
  • Hmrp-2a 3
  • MPIF1 4
  • CKb8 3

External Ids for CCL23 Gene

Previous HGNC Symbols for CCL23 Gene

  • SCYA23

Previous GeneCards Identifiers for CCL23 Gene

  • GC17U990092
  • GC17M036375
  • GC17M034188
  • GC17M034485
  • GC17M031364
  • GC17M034340
  • GC17M030524

Summaries for CCL23 Gene

Entrez Gene Summary for CCL23 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL23 Gene

CCL23 (C-C Motif Chemokine Ligand 23) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot for CCL23 Gene

  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL23 Gene

Genomics for CCL23 Gene

Regulatory Elements for CCL23 Gene

Enhancers for CCL23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL23 on UCSC Golden Path with GeneCards custom track

Promoters for CCL23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCL23 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL23 Gene

Chromosome:
17
Start:
36,013,056 bp from pter
End:
36,017,975 bp from pter
Size:
4,920 bases
Orientation:
Minus strand

Genomic View for CCL23 Gene

Genes around CCL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL23 Gene

Proteins for CCL23 Gene

  • Protein details for CCL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55773-CCL23_HUMAN
    Recommended name:
    C-C motif chemokine 23
    Protein Accession:
    P55773
    Secondary Accessions:
    • B7ZKQ3
    • O00174
    • O75950
    • Q52LD4

    Protein attributes for CCL23 Gene

    Size:
    120 amino acids
    Molecular mass:
    13411 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL23 Gene

    Alternative splice isoforms for CCL23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL23 Gene

Proteomics data for CCL23 Gene at MOPED

Post-translational modifications for CCL23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL23 Gene

Antibody Products

  • R&D Systems Antibodies for CCL23 (CCL23/Ck beta 8-1)
  • R&D Systems Antibodies for CCL23 (CCL23/MPIF-1)

Assay Products

No data available for DME Specific Peptides for CCL23 Gene

Domains & Families for CCL23 Gene

Gene Families for CCL23 Gene

Protein Domains for CCL23 Gene

Suggested Antigen Peptide Sequences for CCL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55773

UniProtKB/Swiss-Prot:

CCL23_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL23: view

Function for CCL23 Gene

Molecular function for CCL23 Gene

UniProtKB/Swiss-Prot Function:
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
genes like me logo Genes that share phenotypes with CCL23: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL23 Gene

Localization for CCL23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL23 Gene COMPARTMENTS Subcellular localization image for CCL23 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for CCL23 Gene

Pathways & Interactions for CCL23 Gene

genes like me logo Genes that share pathways with CCL23: view

Interacting Proteins for CCL23 Gene

Selected Interacting proteins: P55773-CCL23_HUMAN for CCL23 Gene via I2D

Symbol External ID(s) Details
CCR1

Gene Ontology (GO) - Biological Process for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 9886417
GO:0006935 chemotaxis TAS 9104803
GO:0006955 immune response IEA,TAS 9104803
GO:0007165 signal transduction NAS 9886417
genes like me logo Genes that share ontologies with CCL23: view

No data available for SIGNOR curated interactions for CCL23 Gene

Drugs & Compounds for CCL23 Gene

(2) Drugs for CCL23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCL23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL23: view

Transcripts for CCL23 Gene

mRNA/cDNA for CCL23 Gene

Unigene Clusters for CCL23 Gene

Chemokine (C-C motif) ligand 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL23 Gene

No ASD Table

Relevant External Links for CCL23 Gene

GeneLoc Exon Structure for
CCL23
ECgene alternative splicing isoforms for
CCL23

Expression for CCL23 Gene

mRNA expression in normal human tissues for CCL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL23 Gene

This gene is overexpressed in Cervix - Endocervix (x8.0), Cervix - Ectocervix (x4.3), and Spleen (x4.0).

SOURCE GeneReport for Unigene cluster for CCL23 Gene Hs.169191

mRNA Expression by UniProt/SwissProt for CCL23 Gene

P55773-CCL23_HUMAN
Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
genes like me logo Genes that share expression patterns with CCL23: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL23 Gene

Orthologs for CCL23 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL23 35
  • 99.44 (n)
  • 98.33 (a)
Species with no ortholog for CCL23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL23 Gene

ENSEMBL:
Gene Tree for CCL23 (if available)
TreeFam:
Gene Tree for CCL23 (if available)

Paralogs for CCL23 Gene

(17) SIMAP similar genes for CCL23 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL23: view

Variants for CCL23 Gene

Sequence variations from dbSNP and Humsavar for CCL23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1003645 - 36,013,244(-) TTTGC(A/G)TGAGA nc-transcript-variant, reference, missense
rs1005107 -- 36,013,552(-) GGGAA(A/G)GAAGA intron-variant
rs1051516 -- 36,017,865(-) TGCCT(C/G)ATGCT nc-transcript-variant, reference, synonymous-codon
rs1719203 -- 36,013,939(+) GCTCA(A/G)AAGAG intron-variant
rs1719204 -- 36,014,042(+) GGCCA(C/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL23 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850

Variation tolerance for CCL23 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCL23 Gene

Disorders for CCL23 Gene

Relevant External Links for CCL23

Genetic Association Database (GAD)
CCL23
Human Genome Epidemiology (HuGE) Navigator
CCL23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL23

No disorders were found for CCL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL23 Gene

Publications for CCL23 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel V.P. … Garotta G. (J. Exp. Med. 1997) 2 3 4 23 67
  2. CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. (PMID: 19951712) Kim J. … Ko J. (Life Sci. 2010) 3 23
  3. CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression. (PMID: 20097574) Kim J. … Ko J. (Cytokine 2010) 3 23
  4. Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. (PMID: 17513790) Miao Z. … Berahovich R. (J. Immunol. 2007) 3 23
  5. Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. (PMID: 16378600) Son K.N. … Kim J. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for CCL23 Gene

Sources for CCL23 Gene

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