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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL23 Gene

protein-coding GIFtS: 59
GCID: GC17M034340

chemokine (C-C motif) ligand 23

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA23)

Explore 20 diseases affiliated with
CCL23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 23¹ ²		MIP3² ³
SCYA23¹ ² ³ ⁵		CK-BETA-8²
MIP-3¹ ² ³		Ckb-8-1²
MPIF-1¹ ² ³		C-C Motif Chemokine 23²
CKb8¹ ²		C6 Beta-Chemokine²
Ckb-8¹ ²		Hmrp-2a¹
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23¹ ²		CK-Beta-8¹
Macrophage Inflammatory Protein 3² ³		CKB-8³
Myeloid Progenitor Inhibitory Factor 1² ³		MPIF1³
Small-Inducible Cytokine A23² ³

External Ids:	HGNC: 10622¹	Entrez Gene: 6368²	Ensembl: ENSG00000167236⁷	OMIM: 602494⁵	UniProtKB: P55773³

Export aliases for CCL23 gene to outside databases

Previous GC identifers: GC17U990092 GC17M036375 GC17M034188 GC17M034485 GC17M031364 GC17M030524

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL23:

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted

proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two

adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes and

monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong

suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of

this gene is a potent agonist at CC chemokine receptor 1. Two alternatively spliced variants encoding different active

isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773

Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated

lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind

heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the

small-inducible cytokine A23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL23 gene promoter:
HFH-3 GATA-1 FOXL1 Evi-1 FOXI1 PPAR-gamma1 NF-kappaB2 FOXJ2 (long isoform) PPAR-gamma2 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL23 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2

CCL23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL23 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M034340: view genomic region (about GC identifiers)

Start:	34,340,096 bp from pter	End:	34,345,005 bp from pter
Size:	4,910 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773 (See protein sequence)

Recommended Name: C-C motif chemokine 23 precursor

Size: 120 amino acids; 13411 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for CCL23:

1G91 (3D)

Secondary accessions: B7ZKQ3 O00174 O75950 Q52LD4

Alternative splicing: 2 isoforms: P55773-1 P55773-2

Explore the universe of human proteins at neXtProt for CCL23: NX_P55773

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55773

CCL23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005055.2 NP_665905.1

ENSEMBL proteins:

ENSP00000465954 ENSP00000466499 ENSP00000293280

Reactome Protein details: P55773
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CCL23 Protein
	R&D Systems Recombinant & Natural Proteins for CCL23 (CCL23/MPIF-1, CCL23/Ck beta 8-1)
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	Novus Biologicals CCL23 Proteins Novus Biologicals CCL23 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL23
	Uscn Proteins for CCL23

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL23 for ontologies About GeneDecksing

CCL23 Antibody Products:

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	Search for Antibodies for CCL23 at Abcam
	Uscn Antibodies for CCL23
	Search ThermoFisher Antibodies for CCL23

Assay Products for CCL23:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CCL23
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL23 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P55773

ProtoNet protein and cluster: P55773

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773

Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated

lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind

heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the

small-inducible cytokine A23

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL23
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL23
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL23 OriGene shRNA RFP: CCL23 OriGene siRNA: CCL23
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL23

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL23

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL23 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL23 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCL23 (NM_145898)
		Sino Biological Human cDNA Clone for CCL23
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL23

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL23
		Search LifeMap BioReagents cell lines for CCL23

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL23

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IDA	10660125
GO:0008201	heparin binding	IEA	--
GO:0031726	CCR1 chemokine receptor binding	IPI	10660125

CCL23 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CCL23:

Increased HPV18 LCR reporter a

Synthetic lethal with imatinib

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL23 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

5/10 Reactome Pathways for CCL23 (see all 10)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

2 Kegg Pathways (Kegg details for CCL23):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCL23 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL23

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/18 Interacting proteins for CCL23 (P55773³ ENSP00000293280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCR1	P32246³, ENSP00000296140⁴	I2D: score=3 STRING: ENSP00000296140
CCR10	ENSP00000332504⁴	STRING: ENSP00000332504
CCR2	ENSP00000292301⁴	STRING: ENSP00000292301
CCR3	ENSP00000350003⁴	STRING: ENSP00000350003
CCR4	ENSP00000332659⁴	STRING: ENSP00000332659

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002548	monocyte chemotaxis	IC	10660125
GO:0006874	cellular calcium ion homeostasis	TAS	9886417
GO:0006935	chemotaxis	TAS	9104803
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--

CCL23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL23 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL23
3 Novoseek chemical compound relationships for CCL23 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	69.8	13	12381680 (3), 10213461 (2), 10737895 (2), 15818740 (1) (see all 7)
ccl3	58.8	3	15818740 (1), 15588486 (1)
calcium	11.6	9	9886417 (4), 12381680 (2), 9834116 (1)

Search CenterWatch for drugs/clinical trials and news about CCL23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL23 gene (2 alternative transcripts):

NM_005064.3 NM_145898.1

Unigene Cluster for CCL23:

Chemokine (C-C motif) ligand 23

Hs.169191 [show with all ESTs]

Unigene Representative Sequence: NM_005064

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591423 ENST00000588521 ENST00000293280(uc002hks.1 uc002hkt.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL23
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL23 OriGene shRNA RFP: CCL23 OriGene siRNA: CCL23
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL23

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL23 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL23 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCL23 (NM_145898)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL23

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL23 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CCL23
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL23
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL23

Additional cDNA sequence:

BC093970.1 BC143310.1 U58913.1 U67128.1 U85767.1

2 DOTS entries:

DT.100719830 DT.65286450

24/135 AceView cDNA sequences (see all 135):

BM677878 BC038289 CD743105 NM_032963 BI837334 AA345971 AF039955 BC045165

AA699362 AA515108 H22089 NM_005064 NM_145898 AW827147 BX284026 BC050647

NM_004590 AW117461 AK122606 AW514207 BM728235 BE048821 BI823564 AI016701

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL23 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b
SP1:
SP2:					-

ECgene alternative splicing isoforms for CCL23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGCTGA

About this image

CCL23 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCL23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL23

SOURCE GeneReport for Unigene cluster: Hs.169191

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773

Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver,

adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low

abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from

rheumatoid patients

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL23:

Inflammatory Cytokines & Receptors in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Chemokines & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL23 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL23

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL23

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL23 gene from 2/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCL4⁶	chemokine K203	39(a)	1 → many	19(355105-375322)
zebrafish (Danio rerio)	Actinopterygii	si:dkeyp-59a8.2⁶ si:dkeyp-59a8.1⁶ (see all 6)	si:dkeyp-59a8.1 (see all 6)	29(a) 28(a) (see all 6)	many ↔ many many ↔ many (see all 6)	20(38304232-38305101) 20(38282475-38302293)

ENSEMBL Gene Tree for CCL23 (if available)
TreeFam Gene Tree for CCL23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL23 gene

CCL15² CCL16² CCL2² CCL14² CCL24² CCL4L1² CCL11² CCL7²

CCL4L2² CCL3L1² CCL5² CCL3L3² CCL4² CCL8² CCL13² CCL26²

CCL3² CCL18²

18/20 SIMAP similar genes for CCL23 using alignment to 2 protein entries: CCL23_HUMAN (see all proteins) (see all similar genes):

CCL15 CCL17 CCL18 CCL14 CCL24 CCL26

CCL20 CCL3L1 CCL3L3 CCL3 CCL1 CCL4

CCL4L2 LOC728835 CCL4L1 CCL13 CCL5 CCL8

CCL23 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79537341^1,2		--	30524722(+)	`TGTACG/ACAGGA`	2	--	ds500¹		2		CSA WA	120
rs78447961^1,2	F,	--	30524806(+)	`CTTCCC/TCACCT`	2	--	ds500¹		2		NA EA	240
rs76875348^1,2		--	30524876(+)	`AGGTGG/AGTTAC`	2	--	ds500¹		2		CSA WA	120
rs73990623^1,2	C,F,	--	30525297(+)	`GCCCCT/CCAGAT`	2	--	int¹		3		WA CSA	122
rs1005107^1,2	C,F,H,	--	30525460(-)	`GGGAAG/AGAAGA`	2	--	int¹ trp³		10		EA NS NA CSA	558
rs73990624^1,2	C,F,	--	30525510(+)	`TGCAGG/TATCTT`	2	--	int¹		4		WA CSA	124
rs1719203^1,2	H	--	30525847(+)	`GCTCAG/AAAGAG`	2	--	int¹		4		NS EA	418
rs73990626^1,2	C,	--	30526359(+)	`TCAGCA/CTCTCC`	2	--	int¹		2		WA	120
rs57790696^1,2		--	30526867(+)	`GGTTAC/TATATA`	2	--	int¹		0	--	--	--	--
rs75530228^1,2	C,F,	--	30527235(+)	`AGGGAA/CTCTCC`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for CCL23 (34340096 - 34345005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCL23
1 CNV: 4031

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL23

DNA2.0 Custom Variant and Variant Library Synthesis for CCL23

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CCL23 for disorders           About GeneDecksing

OMIM gene information: 602494    OMIM disorders: --

20 diseases for CCL23:    About MalaCards

sialadenitis ascariasis trichuriasis pulmonary sarcoidosis

sarcoidosis bronchiolitis rheumatoid arthritis hepatitis b

t-cell leukemia arthritis thyroid cancer gastric cancer

thyroiditis atherosclerosis hepatitis leukemia

hypoxia tuberculosis mycobacterium tuberculosis hiv type 1

3 Novoseek disease relationships for CCL23 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	9.3	2	17513790 (1), 19951712 (1)
necrosis	4.16	1	10380905 (1)
tumors	0	1	10380905 (1)

Human Genome Epidemiology (HuGE) Navigator: CCL23 (7 documents)

Export disorders for CCL23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCL23 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with CCL23)

Utopia: connect your pdf to the dynamic
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Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PubMed id 9104803)^{1, 2, 3, 9} Patel V.P.... Garotta G. (1997)
Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. (PubMed id 11060285)^{1, 2, 9} Rajarathnam K.... Gentz R. (2001)
Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PubMed id 9558365)^{1, 2, 9} Youn B.-S.... Kwon B.S. (1998)
Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)^{1, 2, 9} Nomiyama H.... Yoshie O. (1999)
Proteolytic activation of alternative CCR1 ligands in inflammation. (PubMed id 15905581)^{1, 2} Berahovich R.D....Schall T.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Physical mapping of the CC-chemokine gene cluster on the human 17q11. 2 region. (PubMed id 10409433)^{1, 3} Maho A....Parmentier M. (1999)
The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)^{1, 2} Wells T.N.C. and Peitsch M.C. (1997)
CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. (PubMed id 19951712)^{1, 9} Kim J....Ko J. (2010)
CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. (PubMed id 10737895)^{1, 9} Votta B.J....Gowen M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6368	HGNC: 10622	AceView: CCL16andCCL23	Ensembl:ENSG00000167236	euGenes: HUgn6368
ECgene: CCL23	Kegg: 6368	H-InvDB: CCL23

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL23	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL23

Intellectual Property for CCL23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCL23 gene:
Search GeneIP for patents involving CCL23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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CCL23 Gene

chemokine (C-C motif) ligand 23

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CCL23 (Gene Symbol)
Chemokine (C-C Motif) Ligand 23
SCYA23
MIP-3
MPIF-1
CKb8
Ckb-8
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23
Macrophage Inflammatory Protein 3
Myeloid Progenitor Inhibitory Factor 1
Small-Inducible Cytokine A23
MIP3
CK-BETA-8
Ckb-8-1
C-C Motif Chemokine 23
C6 Beta-Chemokine
Hmrp-2a
CK-Beta-8
CKB-8
MPIF1

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CCL23 Gene

chemokine (C-C motif) ligand 23

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