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CCL23 Gene

protein-coding   GIFtS: 58
GCID: GC17M034340

Chemokine (C-C Motif) Ligand 23

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 23)
(Previous symbol: SCYA23)
  See CCL23-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 231 2     Ckb-82
SCYA231 2 3 5     Ckb-8-12
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 231 2     C-C Motif Chemokine 232
Macrophage Inflammatory Protein 32 3     C6 Beta-Chemokine2
Myeloid Progenitor Inhibitory Factor 12 3     hmrp-2a2
MIP-32 3     CK-beta-83
MIP32 3     CKB-83
MPIF-12 3     MPIF13
CK-BETA-82     Small-Inducible Cytokine A233
CKb82     

External Ids:    HGNC: 106221   Entrez Gene: 63682   Ensembl: ENSG000001672367   OMIM: 6024945   UniProtKB: P557733   

Export aliases for CCL23 gene to outside databases

Previous GC identifers: GC17U990092 GC17M036375 GC17M034188 GC17M034485 GC17M031364 GC17M030524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL23 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This
chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes,
lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor
of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene
is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript
variants that encode different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL23 Gene:
CCL23 (chemokine (C-C motif) ligand 23) is a protein-coding gene. Diseases associated with CCL23 include sialadenitis. GO annotations related to this gene include CCR1 chemokine receptor binding and heparin binding. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773
Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated
lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind
heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than
the small-inducible cytokine A23




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL23 gene promoter:
         HFH-3   GATA-1   FOXL1   Evi-1   FOXI1   PPAR-gamma1   NF-kappaB2   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL23 promoter sequence
   Search Chromatin IP Primers for CCL23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL23 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034340:  view genomic region     (about GC identifiers)

Start:
34,340,096 bp from pter      End:
34,345,005 bp from pter
Size:
4,910 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773 (See protein sequence)
Recommended Name: C-C motif chemokine 23 precursor  
Size: 120 amino acids; 13411 Da
1 PDB 3D structure from and Proteopedia for CCL23:
1G91 (3D)    
Secondary accessions: B7ZKQ3 O00174 O75950 Q52LD4
Alternative splicing: 2 isoforms:  P55773-1   P55773-2   

Explore the universe of human proteins at neXtProt for CCL23: NX_P55773

Explore proteomics data for CCL23 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCL23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005055.2  NP_665905.1  

    ENSEMBL proteins: 
     ENSP00000465954   ENSP00000466499   ENSP00000293280  

    CCL23 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCL23 Protein
    R&D Systems Recombinant & Natural Proteins for CCL23 (CCL23/MPIF-1, CCL23/Ck beta 8-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL23
    OriGene Protein Over-expression Lysate for CCL23
    OriGene MassSpec for CCL23
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    GenScript Purified and Recombinant Proteins for CCL23
    Novus Biologicals CCL23 Proteins
    Novus Biologicals CCL23 Lysates
    Sino Biological Recombinant Protein for CCL23
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL23
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL23 

    CCL23 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL23 (CCL23/MPIF-1, CCL23/Ck beta 8-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL23
    Novus Biologicals CCL23 Antibodies
    Abcam antibodies for CCL23
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CCL23
    LSBio Antibodies in human, mouse, rat for CCL23

    CCL23 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL23
    R&D Systems ELISAs for CCL23 (CCL23/MPIF-1, CCL23/Ck beta 8-1)
    GenScript Custom Assay Services for CCL23
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL23 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P55773

    ProtoNet protein and cluster: P55773

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL23_HUMAN, P55773
    Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated
    lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind
    heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than
    the small-inducible cytokine A23

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA10660125
    GO:0008201heparin binding IEA--
    GO:0031726CCR1 chemokine receptor binding IPI10660125
         
    Find genes that share ontologies with CCL23           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCL23:
     Increased HPV18 LCR reporter a  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL23
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL23
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL23

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CCL23
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL23
    Predesigned siRNA for gene silencing in human, mouse, rat CCL23

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL23

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL23 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL23 (NM_145898)
    Sino Biological Human cDNA Clone for CCL23
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL23

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL23
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL23 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL23_HUMAN, P55773: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL23 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with CCL23           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL23
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL23 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    2 Kegg Pathways  (Kegg details for CCL23):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL23: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CCL23 (P557733 ENSP000002932804) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR1P322463, ENSP000002961404I2D: score=3 STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR4ENSP000003326594STRING: ENSP00000332659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002548monocyte chemotaxis IC10660125
    GO:0006874cellular calcium ion homeostasis TAS9886417
    GO:0006935chemotaxis TAS9104803
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--

    Find genes that share ontologies with CCL23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL23

    3 Novoseek inferred chemical compound relationships for CCL23 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 69.8 13 12381680 (3), 10213461 (2), 10737895 (2), 15818740 (1) (see all 7)
    ccl3 58.8 3 15818740 (1), 15588486 (1)
    calcium 11.6 9 9886417 (4), 12381680 (2), 9834116 (1)



    Find genes that share compounds with CCL23           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL23 gene (2 alternative transcripts): 
    NM_005064.4  NM_145898.2  

    Unigene Cluster for CCL23:

    Chemokine (C-C motif) ligand 23
    Hs.169191  [show with all ESTs]
    Unigene Representative Sequence: NM_005064
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591423 ENST00000588521 ENST00000293280(uc002hks.1 uc002hkt.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL23 using miScript Target Protectors
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    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCL23
    Predesigned siRNA for gene silencing in human, mouse, rat CCL23
    Clone
    Products:
         
    OriGene clones in human, mouse for CCL23 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL23 (NM_145898)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL23
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL23
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL23
      QuantiTect SYBR Green Assays in human, mouse, rat CCL23
      QuantiFast Probe-based Assays in human, mouse, rat CCL23

    Additional mRNA sequence: 

    BC093970.1 BC143310.1 U58913.1 U67128.1 U85767.1 

    2 DOTS entries:

    DT.100719830  DT.65286450 

    Selected AceView cDNA sequences (see all 135):

    AA515108 AW117461 BI837334 H22089 BC038289 BC045165 AF039955 NM_005064 
    BX284026 AA699362 AA345971 CD743105 NM_032963 BM677878 AK122606 NM_145898 
    BC050647 NM_004590 AW827147 BM728235 AI016701 AX772826 NM_004167 U85767 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL23    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for CCL23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATGCTGA
    CCL23 Expression
    About this image


    CCL23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Lung (Respiratory System)
    CCL23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169191

    UniProtKB/Swiss-Prot: CCL23_HUMAN, P55773
    Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal
    liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only
    in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in
    synovial fluids from rheumatoid patients

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL23: 
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL23
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL23
    QuantiTect SYBR Green Assays in human, mouse, rat CCL23
    QuantiFast Probe-based Assays in human, mouse, rat CCL23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL23 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    29(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378
            Species with no ortholog for CCL23

    ENSEMBL Gene Tree for CCL23 (if available)
    TreeFam Gene Tree for CCL23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL23 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
    CCL52  CCL3L32  CCL182  CCL42  CCL15-CCL142  
    17 SIMAP similar genes for CCL23 using alignment to 2 protein entries:     CCL23_HUMAN (see all proteins):
    CCL15    CCL17    CCL18    CCL14    CCL24    CCL26
    CCL20    CCL3L1    CCL3L3    CCL3    CCL1    CCL4
    CCL4L2    LOC728835    CCL4L1    CCL13    CCL5

    Find genes that share paralogs with CCL23           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL23 (see all 196)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs672466391,2
    C--30526523(+) ACACG-/TTGTTG 2 -- int10--------
    rs577906961,2
    --30526867(+) GGTTAC/TATATA 2 -- int10--------
    rs80655431,2
    C,F,A,H--30526868(+) gttatA/Gtatat 2 -- int14Minor allele frequency- G:0.30NA WA 10
    rs672342541,2
    C--34341224(+) GTTCC-/CATAG 
     CCCGTCC
    TGATC
    2 -- int10--------
    rs340349871,2
    C--34341653(+) AACACT/-GTGTT 2 -- int13Minor allele frequency- -:0.00NA CSA 8
    rs613659451,2
    C--34341995(+) ATATA-/TAACGTA 2 -- int10--------
    rs358942791,2
    C--34346943(+) CATCC-/ATC   
      C
    /CATC
    CAGGG
    2 -- us2k11NA 2
    rs1839829431,2
    --34409858(+) GAAAAA/GCATTT 2 -- ds50010--------
    rs795373411,2
    F--34409989(+) TGTACG/ACAGGA 2 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs1460472391,2
    --34410016(+) CGCTGA/GTGTTC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCL23 (34340096 - 34345005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCL23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833427CNV Loss17160897
    nsv833424CNV Gain17160897
    nsv428340CNV Gain18775914
    dgv945e1CNV Complex17122850
    dgv946e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL23
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602494    OMIM disorders: --

    1 disease for CCL23:    
    About MalaCards
    sialadenitis


    Find genes that share disorders with CCL23           About GenesLikeMe

    3 Novoseek inferred disease relationships for CCL23 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 9.3 2 17513790 (1), 19951712 (1)
    necrosis 4.16 1 10380905 (1)
    tumors 0 1 10380905 (1)

    Genetic Association Database (GAD): CCL23
    Human Genome Epidemiology (HuGE) Navigator: CCL23 (7 documents)

    Export disorders for CCL23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CCL23 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CCL23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PubMed id 9104803)1, 2, 3, 9 Patel V.P.... Garotta G. (J. Exp. Med. 1997)
    2. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. (PubMed id 11060285)1, 2, 9 Rajarathnam K.... Gentz R. (J. Biol. Chem. 2001)
    3. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PubMed id 9558365)1, 2, 9 Youn B.-S.... Kwon B.S. (Blood 1998)
    4. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (J. Interferon Cytokine Res. 1999)
    5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. Proteolytic activation of alternative CCR1 ligands in inflammation. (PubMed id 15905581)1, 2 Berahovich R.D....Schall T.J. (J. Immunol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6368 HGNC: 10622 AceView: CCL16andCCL23 Ensembl:ENSG00000167236 euGenes: HUgn6368
    ECgene: CCL23 Kegg: 6368 H-InvDB: CCL23

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL23 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL23

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCL23 gene:
    Search GeneIP for patents involving CCL23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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