Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL23 Gene

Aliases for CCL23 Gene

  • Chemokine (C-C Motif) Ligand 23 2 3
  • SCYA23 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23 2 3
  • Myeloid Progenitor Inhibitory Factor 1 3 4
  • Macrophage Inflammatory Protein 3 3 4
  • CK-BETA-8 3 4
  • MPIF-1 3 4
  • Ckb-8 3 4
  • MIP-3 3 4
  • MIP3 3 4
  • Small-Inducible Cytokine A23 4
  • C-C Motif Chemokine 23 3
  • C6 Beta-Chemokine 3
  • Ckb-8-1 3
  • Hmrp-2a 3
  • MPIF1 4
  • CKb8 3

External Ids for CCL23 Gene

Previous Symbols for CCL23 Gene

  • SCYA23

Summaries for CCL23 Gene

Entrez Gene Summary for CCL23 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL23 Gene

CCL23 (Chemokine (C-C Motif) Ligand 23) is a Protein Coding gene. Diseases associated with CCL23 include sialadenitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include heparin binding and CCR1 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL23 Gene

  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL23 Gene

Genomics for CCL23 Gene

Genomic Location for CCL23 Gene

Start:
36,013,056 bp from pter
End:
36,018,008 bp from pter
Size:
4,953 bases
Orientation:
Minus strand

Genomic View for CCL23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL23 Gene

Proteins for CCL23 Gene

  • Protein details for CCL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55773-CCL23_HUMAN
    Recommended name:
    C-C motif chemokine 23
    Protein Accession:
    P55773
    Secondary Accessions:
    • B7ZKQ3
    • O00174
    • O75950
    • Q52LD4

    Protein attributes for CCL23 Gene

    Size:
    120 amino acids
    Molecular mass:
    13411 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL23 Gene

    Alternative splice isoforms for CCL23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL23 Gene

Proteomics data for CCL23 Gene at MOPED

Post-translational modifications for CCL23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL23 Gene

No data available for DME Specific Peptides for CCL23 Gene

Domains for CCL23 Gene

Gene Families for CCL23 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL23 Gene

UniProtKB/Swiss-Prot:

CCL23_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • P55773
genes like me logo Genes that share domains with CCL23: view

Function for CCL23 Gene

Molecular function for CCL23 Gene

UniProtKB/Swiss-Prot Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Gene Ontology (GO) - Molecular Function for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 10660125
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 10660125
genes like me logo Genes that share ontologies with CCL23: view

Phenotypes for CCL23 Gene

genes like me logo Genes that share phenotypes with CCL23: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL23 Gene

Localization for CCL23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL23 Gene COMPARTMENTS Subcellular localization image for CCL23 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL23: view

Pathways for CCL23 Gene

genes like me logo Genes that share pathways with CCL23: view

Interacting Proteins for CCL23 Gene

Selected Interacting proteins: P55773-CCL23_HUMAN for CCL23 Gene via I2D

Symbol External ID(s) Details
CCR1

Gene Ontology (GO) - Biological Process for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 9886417
GO:0006935 chemotaxis TAS 9104803
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL23: view

Compounds for CCL23 Gene

(3) Novoseek inferred chemical compound relationships for CCL23 Gene

Compound -log(P) Hits PubMed IDs
rantes 69.8 11
ccl3 58.8 2
calcium 11.6 7
genes like me logo Genes that share compounds with CCL23: view

Transcripts for CCL23 Gene

mRNA/cDNA for CCL23 Gene

Unigene Clusters for CCL23 Gene

Chemokine (C-C motif) ligand 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CCL23 Gene

GeneLoc Exon Structure for
CCL23
ECgene alternative splicing isoforms for
CCL23

Expression for CCL23 Gene

mRNA expression in normal human tissues for CCL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL23 Gene

This gene is overexpressed in Cervix - Endocervix (8.0), Cervix - Ectocervix (4.3), and Spleen (4.0).

SOURCE GeneReport for Unigene cluster for CCL23 Gene Hs.169191

mRNA Expression by UniProt/SwissProt for CCL23 Gene

P55773-CCL23_HUMAN
Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
genes like me logo Genes that share expressions with CCL23: view

Orthologs for CCL23 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL23 36
  • 99.44 (n)
  • 98.33 (a)
Species with no ortholog for CCL23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL23 Gene

ENSEMBL:
Gene Tree for CCL23 (if available)
TreeFam:
Gene Tree for CCL23 (if available)

Paralogs for CCL23 Gene

Selected SIMAP similar genes for CCL23 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL23: view

No data available for Paralogs for CCL23 Gene

Variants for CCL23 Gene

Sequence variations from dbSNP and Humsavar for CCL23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs854655 -- 36,018,186(+) TGGAT(A/C)CTTCC upstream-variant-2KB
rs854656 -- 36,018,624(+) cccta(A/C)ttcca upstream-variant-2KB
rs854657 -- 36,018,997(+) gagtg(A/G)gtttg upstream-variant-2KB
rs860559 -- 36,019,230(+) atcct(C/T)tcatg upstream-variant-2KB
rs861273 -- 36,019,161(+) ttagt(A/G)atcag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL23 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850

Relevant External Links for CCL23 Gene

HapMap Linkage Disequilibrium report
CCL23

Disorders for CCL23 Gene

(1) MalaCards Diseases for CCL23 Gene

Search for CCL23 Gene in MalaCards »

(3) Novoseek inferred disease relationships for CCL23 Gene

Disease -log(P) Hits PubMed IDs
inflammation 9.3 2
necrosis 4.16 1
tumors 0 1

Relevant External Links for CCL23

Genetic Association Database (GAD)
CCL23
Human Genome Epidemiology (HuGE) Navigator
CCL23
genes like me logo Genes that share disorders with CCL23: view

No data available for UniProtKB/Swiss-Prot for CCL23 Gene

Publications for CCL23 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel V.P. … Garotta G. (J. Exp. Med. 1997) 2 3 4 23
  2. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PMID: 9558365) Youn B.-S. … Kwon B.S. (Blood 1998) 3 4 23
  3. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. (PMID: 11060285) Rajarathnam K. … Gentz R. (J. Biol. Chem. 2001) 3 4 23
  4. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 4 23
  5. CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. (PMID: 19951712) Kim J. … Ko J. (Life Sci. 2010) 3 23

Products for CCL23 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL23
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL23
    • Block miRNA regulation of CCL23 using miScript Target Protectors

    Sources for CCL23 Gene

    Back to Top

    Content