Aliases for CCL23 Gene
External Ids for CCL23 Gene
Previous Symbols for CCL23 Gene
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for CCL23 Gene
CCL23 (Chemokine (C-C Motif) Ligand 23) is a Protein Coding gene. Diseases associated with CCL23 include sialadenitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include heparin binding and CCR1 chemokine receptor binding.
UniProtKB/Swiss-Prot for CCL23 Gene
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.