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CCL22 Gene

protein-coding   GIFtS: 60
GCID: GC16P057392

Chemokine (C-C Motif) Ligand 22

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 22)
(Previous symbol: SCYA22)
  See CCL22-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 221 2     CC Chemokine STCP-12 3
SCYA221 2 3 5     ABCD-12
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 221 2     DC/B-CK2
Macrophage-Derived Chemokine2 3     STCP-12
Small-Inducible Cytokine A222 3     C-C Motif Chemokine 222
Stimulated T-Cell Chemotactic Protein 12 3     Small Inducible Cytokine A222
MDC2 3     Stimulated T Cell Chemotactic Protein 12
MDC(1-69)2 3     

External Ids:    HGNC: 106211   Entrez Gene: 63672   Ensembl: ENSG000001029627   OMIM: 6029575   UniProtKB: O006263   

Export aliases for CCL22 gene to outside databases

Previous GC identifers: GC16P047788 GC16P057452 GC16P057127 GC16P057168 GC16P055950 GC16P043260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL22 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also
displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils,
eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine
may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of
activated T lymphocyte physiology. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL22 Gene:
CCL22 (chemokine (C-C motif) ligand 22) is a protein-coding gene. Diseases associated with CCL22 include atopic keratoconjunctivitis, and mycosis fungoides. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other
aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer
cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically
activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting
T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

Gene Wiki entry for CCL22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL22 gene promoter:
         GATA-3   AP-1   ATF-2   IRF-7A   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL22 promoter sequence
   Search Chromatin IP Primers for CCL22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CCL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL22 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057392:  view genomic region     (about GC identifiers)

Start:
57,392,684 bp from pter      End:
57,400,102 bp from pter
Size:
7,419 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626 (See protein sequence)
Recommended Name: C-C motif chemokine 22 precursor  
Size: 93 amino acids; 10625 Da
Secondary accessions: A0N0Q6 B2R4W2

Explore the universe of human proteins at neXtProt for CCL22: NX_O00626

Explore proteomics data for CCL22 at MOPED

Post-translational modifications: 

  • The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after
    secretion from monocyte derived dendrocytes1
  • Modification sites at neXtProt

  • See CCL22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002981.2  
    ENSEMBL proteins: 
     ENSP00000219235  
    Reactome Protein details: O00626

    CCL22 Human Recombinant Protein Products:

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    OriGene Purified Protein for CCL22
    OriGene Protein Over-expression Lysate for CCL22
    OriGene MassSpec for CCL22
    OriGene Custom Protein Services for CCL22
    GenScript Purified and Recombinant Proteins for CCL22
    Novus Biologicals CCL22 Proteins
    Novus Biologicals CCL22 Lysate
    Sino Biological Recombinant Protein for CCL22
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL22
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL22 

     
    antibodies-online proteins for CCL22 (56 products) 

     
    antibodies-online peptides for CCL22

    CCL22 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL22 (CCL22/MDC)
    Browse OriGene Antibodies
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    Novus Biologicals CCL22 Antibodies
    Abcam antibodies for CCL22
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL22
    antibodies-online antibodies for CCL22 (82 products) 

    CCL22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL22
    R&D Systems ELISAs for CCL22 (CCL22/MDC)         (see all)
    GenScript Custom Assay Services for CCL22
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL22 
    antibodies-online kits for CCL22 (61 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O00626

    ProtoNet protein and cluster: O00626

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL22_HUMAN, O00626
    Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other
    aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer
    cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically
    activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting
    T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CCL22           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccl22):
     nervous system 

    Find genes that share phenotypes with CCL22           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL22

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL22:
    hsa-mir-34a-5p (MIRT006869)

    Block miRNA regulation of human, mouse, rat CCL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL22 (see all 27):
    hsa-miR-194* hsa-miR-4254 hsa-miR-4251 hsa-miR-3614-3p hsa-miR-765 hsa-miR-374a hsa-miR-1285 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCL22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL22
    Predesigned siRNA for gene silencing in human, mouse, rat CCL22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL22

    Clone
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    OriGene clones in human, mouse for CCL22 (see all 6)
    OriGene ORF clones in mouse, rat for CCL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL22 (NM_002990)
    Sino Biological Human cDNA Clone for CCL22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL22

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL22
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL22_HUMAN, O00626: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL22 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71


    Find genes that share SuperPaths with CCL22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL22
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL22 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    1 Reactome Pathway for CCL22
        Chemokine receptors bind chemokines


    2 Kegg Pathways  (Kegg details for CCL22):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL22 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL22 (O006262, 3 ENSP000002192354) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091012 I2D: score=3 STRING: ENSP00000353731
    CCL19Q997313, ENSP000003088154I2D: score=3 STRING: ENSP00000308815
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    CCR7P322483, ENSP000002466574I2D: score=1 STRING: ENSP00000246657
    VCAM1P193203, ENSP000002947284I2D: score=4 STRING: ENSP00000294728
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10861057
    GO:0006954inflammatory response TAS9151897
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9743322
    GO:0007267cell-cell signaling TAS9151897

    Find genes that share ontologies with CCL22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL22

    Selected Novoseek inferred chemical compound relationships for CCL22 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 98 262 9430724 (9), 12645858 (9), 15813816 (7), 12715916 (6) (see all 87)
    ccl3 81.8 16 15256380 (2), 12534281 (1), 14657379 (1), 16905241 (1) (see all 13)
    rantes 78 34 16343773 (3), 10961862 (2), 17460400 (2), 11238053 (2) (see all 23)
    ccl4 58 10 14657379 (1), 16905241 (1), 17369706 (1), 14747532 (1) (see all 9)
    larc 55.6 2 11001915 (1), 11792124 (1)
    sb 203580 20.7 3 16761312 (1), 17617806 (1)
    pertussis 17.4 1 15167983 (1)
    adp 15.4 10 11172816 (2), 15054038 (2), 11159520 (1), 10891429 (1)
    calcium 9.46 31 15167983 (4), 10069890 (3), 11248289 (3), 9430724 (3) (see all 10)
    leukotriene b4 3.64 4 16055623 (2)



    Find genes that share compounds with CCL22           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL22 gene: 
    NM_002990.4  

    Unigene Cluster for CCL22:

    Chemokine (C-C motif) ligand 22
    Hs.534347  [show with all ESTs]
    Unigene Representative Sequence: NM_002990
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000219235(uc002elh.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CCL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL22 (see all 27):
    hsa-miR-194* hsa-miR-4254 hsa-miR-4251 hsa-miR-3614-3p hsa-miR-765 hsa-miR-374a hsa-miR-1285 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCL22 3' UTR sequence
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL22
      QuantiTect SYBR Green Assays in human, mouse, rat CCL22
      QuantiFast Probe-based Assays in human, mouse, rat CCL22

    Additional mRNA sequence: 

    AK311970.1 BC027952.1 U83171.1 U83239.1 

    2 DOTS entries:

    DT.403562  DT.120667567 

    19 AceView cDNA sequences:

    BG235968 AA907433 NM_002990 BX279647 BC027952 U83239 BV198323 BI521552 
    CA430446 U83171 BM977006 AV713579 BV186568 BV198324 CD698350 CD708976 
    CD703658 CD710019 CD705857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGGGGCCC
    CCL22 Expression
    About this image

    CCL22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534347

    UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
    Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found
    in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and
    spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells
    (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy.
    Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL22 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL22
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    QuantiFast Probe-based Assays in human, mouse, rat CCL22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL22 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl221 , 5 chemokine (C-C motif) ligand 221, 5 74.65(n)1
    63.38(a)1
      8 (46.75 cM)5
    202991  NM_009137.21  NP_033163.11 
     947455905 


    ENSEMBL Gene Tree for CCL22 (if available)
    TreeFam Gene Tree for CCL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL22 gene
    Selected SIMAP similar genes for CCL22 using alignment to 1 protein entry:     CCL22_HUMAN(see all similar genes):
    CCL4    CCL4L2    CCL5    CCL15    CCL2    CCL3
    CCL4L1    CCL7    MCP-3    CCL19    CCL13    CCL14
    LOC728835    CCL16    CCL17    CCL21    CCL3L1    CCL3L3

    Find genes that share paralogs with CCL22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL22 (see all 259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2022186391,2
    --57390787(+) CAACG-/ACAACAAC 1 -- us2k10--------
    rs1423508011,2
    C--57390827(+) ACATCC/TGCAAA 1 -- us2k10--------
    rs348854821,2
    C,F--57390934(+) TAAATG/ATTTGC 1 -- us2k15Minor allele frequency- A:0.24NA EA 246
    rs727848941,2
    C,F--57390954(+) GAATTG/TGATGA 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs713827741,2
    C--57391111(+) TCTTT-/C/TTTT
            
    TTTTT
    1 -- us2k11NA 2
    rs1830643091,2
    --57391145(+) GGACTC/TTCATT 1 -- us2k10--------
    rs2238871,2
    C,F,A,H--57391214(+) caccgT/Gattca 1 -- us2k110Minor allele frequency- G:0.44NA WA CSA EA 369
    rs1875348221,2
    --57391248(+) CCCCAA/GGTAGC 1 -- us2k10--------
    rs1920168331,2
    --57391267(+) CAGGCG/TCATGC 1 -- us2k10--------
    rs713871621,2
    C,F--57391270(+) GCGCAT/AGCCAT 1 -- us2k14Minor allele frequency- A:0.12NA EA 244

    HapMap Linkage Disequilibrium report for CCL22 (57392684 - 57400102 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCL22: --
    Human Gene Mutation Database (HGMD): CCL22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL22
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602957    OMIM disorders: --

    14 diseases for CCL22:    
    About MalaCards
    atopic keratoconjunctivitis    mycosis fungoides    allergic bronchopulmonary aspergillosis    atopic dermatitis
    vernal keratoconjunctivitis    erythema multiforme    allergic contact dermatitis    pulmonary fibrosis
    keratoconjunctivitis    interstitial lung disease    pneumonia    abdominal aortic aneurysm
    atopy    idiopathic pulmonary fibrosis

    2 diseases from the University of Copenhagen DISEASES database for CCL22:
    Atopic dermatitis     Asthma

    Find genes that share disorders with CCL22           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL22 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 71.5 17 10602042 (2), 12715916 (2), 15813816 (2), 18266834 (2) (see all 11)
    inflammation 50 19 15993846 (2), 17617806 (2), 18451325 (1), 20170340 (1) (see all 14)
    pulmonary fibrosis 49.4 8 15383605 (3), 19715610 (2), 15293604 (1), 15993846 (1)
    fibrosis idiopathic pulmonary 47.9 6 15293604 (3), 19715610 (1)
    mycosis fungoides 47 2 10602042 (1), 15927812 (1)
    asthma 46.6 14 12645858 (3), 16393265 (2), 12925672 (1), 14616122 (1) (see all 10)
    pneumonia eosinophilic 43.3 1 12757454 (1)
    necrosis 34.1 17 9581805 (2), 11483776 (1), 11923841 (1), 11001915 (1) (see all 13)
    bronchoalveolar lavage fluid 30.6 4 12757454 (2), 15293604 (1), 15751278 (1)
    skin lesion 26.4 4 11241286 (1), 17071491 (1), 16583210 (1), 18266834 (1)

    Genetic Association Database (GAD): CCL22
    Human Genome Epidemiology (HuGE) Navigator: CCL22 (7 documents)

    Export disorders for CCL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CCL22 gene, integrated from 10 sources (see all 291):
    (articles sorted by number of sources associating them with CCL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. (PubMed id 9151897)1, 2, 3, 9 Godiska R.... Gray P.W. (J. Exp. Med. 1997)
    2. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)1, 2, 9 Imai T.... Gray P.W. (J. Biol. Chem. 1998)
    3. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. (PubMed id 11241286)1, 2, 9 Vulcano M.... Sozzani S. (Eur. J. Immunol. 2001)
    4. Genetic polymorphism in chemokine CCL22 and susceptibility to Helicobacter pylori infection-related gastric carcinoma. (PubMed id 19298002)1, 4, 9 Wang G....Lin D. (Cancer 2009)
    5. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. (PubMed id 9312138)1, 2, 9 Chang M.-S.... Andrew D.P. (J. Biol. Chem. 1997)
    6. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. (PubMed id 9691168)1, 3, 9 Nomiyama H....Yoshie O. (Cytogenet. Cell Genet. 1998)
    7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis. (PubMed id 17967467)1, 4 Galimberti D....Scarpini E. (J. Neurol. Sci. 2008)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6367 HGNC: 10621 AceView: CCL22 Ensembl:ENSG00000102962 euGenes: HUgn6367
    ECgene: CCL22 Kegg: 6367 H-InvDB: CCL22

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL22 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL22

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCL22 gene:
    Search GeneIP for patents involving CCL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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