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Aliases for CCL22 Gene

Aliases for CCL22 Gene

  • Chemokine (C-C Motif) Ligand 22 2 3
  • SCYA22 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22 2 3
  • Stimulated T-Cell Chemotactic Protein 1 3 4
  • Macrophage-Derived Chemokine 3 4
  • Small-Inducible Cytokine A22 3 4
  • CC Chemokine STCP-1 3 4
  • MDC(1-69) 3 4
  • MDC 3 4
  • Stimulated T Cell Chemotactic Protein 1 3
  • Small Inducible Cytokine A22 3
  • C-C Motif Chemokine 22 3
  • A-152E5.1 3
  • DC/B-CK 3
  • ABCD-1 3
  • STCP-1 3

External Ids for CCL22 Gene

Previous HGNC Symbols for CCL22 Gene

  • SCYA22

Previous GeneCards Identifiers for CCL22 Gene

  • GC16P047788
  • GC16P057452
  • GC16P057127
  • GC16P057168
  • GC16P055950
  • GC16P057392
  • GC16P043260

Summaries for CCL22 Gene

Entrez Gene Summary for CCL22 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL22 Gene

CCL22 (Chemokine (C-C Motif) Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include atopic keratoconjunctivitis and mycosis fungoides. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL22 Gene

  • May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

Gene Wiki entry for CCL22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL22 Gene

Genomics for CCL22 Gene

Regulatory Elements for CCL22 Gene

Genomic Location for CCL22 Gene

Start:
57,358,772 bp from pter
End:
57,366,190 bp from pter
Size:
7,419 bases
Orientation:
Plus strand

Genomic View for CCL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL22 Gene

Proteins for CCL22 Gene

  • Protein details for CCL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00626-CCL22_HUMAN
    Recommended name:
    C-C motif chemokine 22
    Protein Accession:
    O00626
    Secondary Accessions:
    • A0N0Q6
    • B2R4W2

    Protein attributes for CCL22 Gene

    Size:
    93 amino acids
    Molecular mass:
    10625 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL22 Gene

Proteomics data for CCL22 Gene at MOPED

Post-translational modifications for CCL22 Gene

  • The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CCL22 Gene

Domains for CCL22 Gene

Gene Families for CCL22 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL22 Gene

Suggested Antigen Peptide Sequences for CCL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00626

UniProtKB/Swiss-Prot:

CCL22_HUMAN :
  • O00626
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL22: view

Function for CCL22 Gene

Molecular function for CCL22 Gene

UniProtKB/Swiss-Prot Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

Gene Ontology (GO) - Molecular Function for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL22: view

Phenotypes for CCL22 Gene

MGI mutant phenotypes for CCL22:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CCL22: view

Animal Model Products

CRISPR Products

miRNA for CCL22 Gene

miRTarBase miRNAs that target CCL22

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL22 Gene

Localization for CCL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL22 Gene COMPARTMENTS Subcellular localization image for CCL22 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL22: view

Pathways for CCL22 Gene

genes like me logo Genes that share pathways with CCL22: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10861057
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9743322
GO:0007267 cell-cell signaling TAS 9151897
genes like me logo Genes that share ontologies with CCL22: view

Compounds for CCL22 Gene

(23) Novoseek inferred chemical compound relationships for CCL22 Gene

Compound -log(P) Hits PubMed IDs
tarc 98 213
ccl3 81.8 14
rantes 78 28
ccl4 58 9
larc 55.6 2
genes like me logo Genes that share compounds with CCL22: view

Transcripts for CCL22 Gene

mRNA/cDNA for CCL22 Gene

(19) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL22 Gene

Chemokine (C-C motif) ligand 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL22 Gene

No ASD Table

Relevant External Links for CCL22 Gene

GeneLoc Exon Structure for
CCL22
ECgene alternative splicing isoforms for
CCL22

Expression for CCL22 Gene

mRNA expression in normal human tissues for CCL22 Gene

SOURCE GeneReport for Unigene cluster for CCL22 Gene Hs.534347

mRNA Expression by UniProt/SwissProt for CCL22 Gene

O00626-CCL22_HUMAN
Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans cells (CD1a+ and CD83+). Expressed in Langerhans cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
genes like me logo Genes that share expressions with CCL22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for CCL22 Gene

Orthologs for CCL22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL22 35
  • 99.54 (n)
  • 100 (a)
CCL22 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL22 35
  • 80.65 (n)
  • 73.12 (a)
CCL22 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL22 35
  • 82.42 (n)
  • 71.43 (a)
CCL22 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl22 35
  • 74.65 (n)
  • 63.38 (a)
Ccl22 16
Ccl22 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL22 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCL22 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl22 35
  • 75.12 (n)
  • 64.79 (a)
Species with no ortholog for CCL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL22 Gene

ENSEMBL:
Gene Tree for CCL22 (if available)
TreeFam:
Gene Tree for CCL22 (if available)

Paralogs for CCL22 Gene

Selected SIMAP similar genes for CCL22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL22: view

No data available for Paralogs for CCL22 Gene

Variants for CCL22 Gene

Sequence variations from dbSNP and Humsavar for CCL22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs121565 -- 57,365,437(+) AGGTG(A/G/T)AGCTT utr-variant-3-prime
rs170359 -- 57,361,752(+) CTGGG(A/G)AGGCT intron-variant
rs170360 -- 57,364,038(-) TTCTG(A/G)GTGTC utr-variant-3-prime
rs182668 -- 57,357,479(+) tgctg(A/G)gatta upstream-variant-2KB
rs223816 -- 57,359,375(+) cagtg(A/G)ggcaa intron-variant

Relevant External Links for CCL22 Gene

HapMap Linkage Disequilibrium report
CCL22
Human Gene Mutation Database (HGMD)
CCL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL22 Gene

Disorders for CCL22 Gene

(2) University of Copenhagen DISEASES for CCL22 Gene

(33) Novoseek inferred disease relationships for CCL22 Gene

Disease -log(P) Hits PubMed IDs
dermatitis atopic 71.5 15
inflammation 50 16
pulmonary fibrosis 49.4 7
fibrosis idiopathic pulmonary 47.9 4
mycosis fungoides 47 2

Relevant External Links for CCL22

Genetic Association Database (GAD)
CCL22
Human Genome Epidemiology (HuGE) Navigator
CCL22
genes like me logo Genes that share disorders with CCL22: view

No data available for UniProtKB/Swiss-Prot for CCL22 Gene

Publications for CCL22 Gene

  1. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. (PMID: 9151897) Godiska R. … Gray P.W. (J. Exp. Med. 1997) 2 3 4 23
  2. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. (PMID: 9312138) Chang M.-S. … Andrew D.P. (J. Biol. Chem. 1997) 3 4 23
  3. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PMID: 9430724) Imai T. … Gray P.W. (J. Biol. Chem. 1998) 3 4 23
  4. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. (PMID: 9691168) Nomiyama H. … Yoshie O. (Cytogenet. Cell Genet. 1998) 2 3 23
  5. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. (PMID: 11241286) Vulcano M. … Sozzani S. (Eur. J. Immunol. 2001) 3 4 23

Products for CCL22 Gene

Sources for CCL22 Gene

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