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Aliases for CCL22 Gene

Aliases for CCL22 Gene

  • C-C Motif Chemokine Ligand 22 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22 2 3
  • Chemokine (C-C Motif) Ligand 22 2 3
  • Macrophage-Derived Chemokine 3 4
  • CC Chemokine STCP-1 3 4
  • MDC(1-69) 3 4
  • SCYA22 3 4
  • MDC 3 4
  • Stimulated T Cell Chemotactic Protein 1 3
  • Stimulated T-Cell Chemotactic Protein 1 4
  • Small Inducible Cytokine A22 3
  • Small-Inducible Cytokine A22 4
  • C-C Motif Chemokine 22 3
  • A-152E5.1 3
  • DC/B-CK 3
  • ABCD-1 3
  • STCP-1 3

External Ids for CCL22 Gene

Previous HGNC Symbols for CCL22 Gene

  • SCYA22

Previous GeneCards Identifiers for CCL22 Gene

  • GC16P047788
  • GC16P057452
  • GC16P057127
  • GC16P057168
  • GC16P055950
  • GC16P057392
  • GC16P043260

Summaries for CCL22 Gene

Entrez Gene Summary for CCL22 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL22 Gene

CCL22 (C-C Motif Chemokine Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include Atopic Dermatitis and Eosinophilic Pneumonia. Among its related pathways are Akt Signaling and Th2 Differentiation Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL22 Gene

  • May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Gene Wiki entry for CCL22 Gene

Additional gene information for CCL22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL22 Gene

Genomics for CCL22 Gene

Regulatory Elements for CCL22 Gene

Enhancers for CCL22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H057343 1.1 FANTOM5 Ensembl ENCODE 33.8 -15.1 -15122 0 EED IKZF1 IKZF2 SPI1 CCL22 CX3CL1 LOC105371286 ENSG00000271456
GH16H057298 1.7 Ensembl ENCODE dbSUPER 11.8 -58.7 -58693 2 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A PPARGC1A MEF2D SSRP1 RSPRY1 POLR2C CSNK2A2 FAM192A CCL22 CX3CL1 ARL2BP CIAPIN1 COQ9 NUDT21
GH16H057303 1.5 Ensembl ENCODE dbSUPER 12 -54.1 -54080 2 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ATF7 RUNX3 CCL22 CX3CL1 PLLP ARL2BP TRL-CAG2-2 RPL23AP91
GH16H057387 1.2 FANTOM5 ENCODE 13.3 +29.4 29431 1 HDGF PKNOX1 TBL1XR1 BMI1 BATF ZNF121 ZNF366 ZNF207 ATF7 ETV6 NUDT21 RSPRY1 LOC105371286 CCL22 LOC101927556 CIAPIN1 POLR2C CFAP20 CCL17 GC16M057308
GH16H057416 1.3 Ensembl ENCODE 11.8 +59.2 59175 3 HDGF FOXA2 ARID4B ZNF2 YY1 GATA2 ZNF143 ZNF207 RUNX3 REST CIAPIN1 NUDT21 CX3CL1 CCL22 PLLP POLR2C ARL2BP GC16P057430 CCL17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL22 Gene

Chromosome:
16
Start:
57,358,772 bp from pter
End:
57,366,190 bp from pter
Size:
7,419 bases
Orientation:
Plus strand

Genomic View for CCL22 Gene

Genes around CCL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL22 Gene

Proteins for CCL22 Gene

  • Protein details for CCL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00626-CCL22_HUMAN
    Recommended name:
    C-C motif chemokine 22
    Protein Accession:
    O00626
    Secondary Accessions:
    • A0N0Q6
    • B2R4W2

    Protein attributes for CCL22 Gene

    Size:
    93 amino acids
    Molecular mass:
    10625 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL22 Gene

Post-translational modifications for CCL22 Gene

  • The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CCL22

Assay Products

  • Abcam assays for CCL22

No data available for DME Specific Peptides for CCL22 Gene

Domains & Families for CCL22 Gene

Gene Families for CCL22 Gene

Protein Domains for CCL22 Gene

Suggested Antigen Peptide Sequences for CCL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00626

UniProtKB/Swiss-Prot:

CCL22_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL22: view

Function for CCL22 Gene

Molecular function for CCL22 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Gene Ontology (GO) - Molecular Function for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA,TAS --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL22: view
genes like me logo Genes that share phenotypes with CCL22: view

Animal Models for CCL22 Gene

MGI Knock Outs for CCL22:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL22

CRISPR Products

miRNA for CCL22 Gene

miRTarBase miRNAs that target CCL22

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCL22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL22 Gene

Localization for CCL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL22 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,TAS --
genes like me logo Genes that share ontologies with CCL22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL22 Gene

Pathways & Interactions for CCL22 Gene

genes like me logo Genes that share pathways with CCL22: view

Gene Ontology (GO) - Biological Process for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10861057
GO:0006954 inflammatory response TAS,IBA --
GO:0006955 immune response TAS 10861057
GO:0007165 signal transduction TAS 9743322
genes like me logo Genes that share ontologies with CCL22: view

No data available for SIGNOR curated interactions for CCL22 Gene

Drugs & Compounds for CCL22 Gene

(13) Drugs for CCL22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for CCL22 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL22: view

Transcripts for CCL22 Gene

mRNA/cDNA for CCL22 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL22 Gene

Chemokine (C-C motif) ligand 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCL22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCL22 Gene

No ASD Table

Relevant External Links for CCL22 Gene

GeneLoc Exon Structure for
CCL22
ECgene alternative splicing isoforms for
CCL22

Expression for CCL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL22 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL22 Gene:

CCL22

SOURCE GeneReport for Unigene cluster for CCL22 Gene:

Hs.534347

mRNA Expression by UniProt/SwissProt for CCL22 Gene:

O00626-CCL22_HUMAN
Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans cells (CD1a+ and CD83+). Expressed in Langerhans cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.

Evidence on tissue expression from TISSUES for CCL22 Gene

  • Blood(4.6)
  • Lymph node(4.5)
  • Spleen(4.5)
  • Pancreas(4)
  • Skin(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CCL22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL22 Gene

Orthologs for CCL22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL22 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia CCL22 33 34
  • 82.42 (n)
cow
(Bos Taurus)
Mammalia CCL22 33 34
  • 80.65 (n)
rat
(Rattus norvegicus)
Mammalia Ccl22 33
  • 75.12 (n)
mouse
(Mus musculus)
Mammalia Ccl22 33 16 34
  • 74.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCL22 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL22 34
  • 46 (a)
OneToOne
Species where no ortholog for CCL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL22 Gene

ENSEMBL:
Gene Tree for CCL22 (if available)
TreeFam:
Gene Tree for CCL22 (if available)

Paralogs for CCL22 Gene

(22) SIMAP similar genes for CCL22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL22: view

No data available for Paralogs for CCL22 Gene

Variants for CCL22 Gene

Sequence variations from dbSNP and Humsavar for CCL22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000265398 -- 57,364,793(+) TCCCC(A/C)CCCCC utr-variant-3-prime
rs1000431473 -- 57,356,288(+) ATTTA(C/T)TATCC upstream-variant-2KB
rs1000702852 -- 57,360,155(+) GAGGA(A/G)GAAAT intron-variant
rs1001094580 -- 57,366,595(+) TCCAA(A/T)TCTCA downstream-variant-500B
rs1001701101 -- 57,357,489(+) ACAGT(C/T)ATGAA upstream-variant-2KB

Variation tolerance for CCL22 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL22 Gene

Human Gene Mutation Database (HGMD)
CCL22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL22 Gene

Disorders for CCL22 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CCL22 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atopic dermatitis
  • allergic eczema
eosinophilic pneumonia
  • pneumonia, eosinophilic
dermatitis
  • eczema
necatoriasis
apple allergy
  • malus domestica fruit allergy
- elite association - COSMIC cancer census association via MalaCards
Search CCL22 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL22

Genetic Association Database (GAD)
CCL22
Human Genome Epidemiology (HuGE) Navigator
CCL22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL22
genes like me logo Genes that share disorders with CCL22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL22 Gene

Publications for CCL22 Gene

  1. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. (PMID: 9151897) Godiska R … Gray PW (The Journal of experimental medicine 1997) 2 3 4 22 60
  2. Genetic polymorphism in chemokine CCL22 and susceptibility to Helicobacter pylori infection-related gastric carcinoma. (PMID: 19298002) Wang G … Lin D (Cancer 2009) 3 22 45 60
  3. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. (PMID: 11241286) Vulcano M … Sozzani S (European journal of immunology 2001) 3 4 22 60
  4. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PMID: 9430724) Imai T … Gray PW (The Journal of biological chemistry 1998) 3 4 22 60
  5. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. (PMID: 9691168) Nomiyama H … Yoshie O (Cytogenetics and cell genetics 1998) 2 3 22 60

Products for CCL22 Gene

Sources for CCL22 Gene

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