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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL22 Gene

protein-coding   GIFtS: 62
GCID: GC16P057392

chemokine (C-C motif) ligand 22

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA22)
 Explore 68 diseases affiliated with
CCL22 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL22    

Aliases
for CCL22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 221 2     Stimulated T-Cell Chemotactic Protein 12 3
SCYA221 2 3 5     MDC(1-69)2 3
MDC1 2 3     CC Chemokine STCP-12 3
ABCD-11 2     A-152E5.11
DC/B-CK1 2     MGC345541
STCP-11 2     C-C Motif Chemokine 222
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 221 2     Small Inducible Cytokine A222
Macrophage-Derived Chemokine2 3     Stimulated T Cell Chemotactic Protein 12
Small-Inducible Cytokine A222 3     

External Ids:    HGNC: 106211   Entrez Gene: 63672   Ensembl: ENSG000001029627   OMIM: 6029575   UniProtKB: O006263   

Export aliases for CCL22 gene to outside databases

Previous GC identifers: GC16P047788 GC16P057452 GC16P057127 GC16P057168 GC16P055950 GC16P043260


Summaries
for CCL22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL22:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family
of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for
monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild
activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and
resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in
the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte
physiology. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other
aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells.
Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated
T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to
CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

Gene Wiki entry for CCL22


Genomic Views
for CCL22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL22 gene promoter:
         GATA-3   AP-1   ATF-2   IRF-7A   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CCL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL22 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057392:  view genomic region     (about GC identifiers)

Start:
 57,392,684 bp from pter      End:
 57,400,102 bp from pter
Size:
 7,419 bases      Orientation:
 plus strand

Proteins
for CCL22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626 (See protein sequence)
Recommended Name: C-C motif chemokine 22 precursor  
Size: 93 amino acids; 10625 Da
Subcellular location: Secreted
Secondary accessions: A0N0Q6 B2R4W2

Explore the universe of human proteins at neXtProt for CCL22: NX_O00626

Post-translational modifications:

  • The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion
    • from monocyte derived dendrocytes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00626

    • CCL22 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002981.2  
    ENSEMBL proteins: 
     ENSP00000219235  
    Reactome Protein details: O00626
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL22 (CCL22/MDC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CCL22
    OriGene Protein Over-expression Lysate: CCL22
    OriGene Custom Protein Services for CCL22 
    GenScript Purified and Recombinant Proteins for CCL22
    Novus Biologicals CCL22 Proteins
    Novus Biologicals CCL22 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL22
    Uscn Proteins for CCL22

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--


    CCL22 for ontologies           About GeneDecksing



    CCL22 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies (see all 2): CCL22
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    GenScript Custom Superior Antibodies Services for CCL22
    Novus Biologicals CCL22 Antibodies
    Search for Antibodies for CCL22 at Abcam  
    Uscn Antibodies for CCL22
    ThermoFisher Antibodies for CCL22

    Assay Products for CCL22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for CCL22 (CCL22/MDC)         (see all)
    GenScript Custom Assay Services for CCL22
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCL22

    Protein Domains /
    Families
    for CCL22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCL22 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O00626

    ProtoNet protein and cluster: O00626

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Function
    for CCL22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
    Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other
    aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells.
    Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated
    T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to
    CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CCL22
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL22
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL22 (see all 27):
    hsa-miR-194* hsa-miR-4254 hsa-miR-4251 hsa-miR-3614-3p hsa-miR-765 hsa-miR-374a hsa-miR-1285 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CCL22 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL22 (see all 7)
    OriGene shRNA RFP: CCL22
    OriGene siRNA: CCL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL22

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCL22

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL22 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL22
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL22 (NM_002990)
    Sino Biological Human cDNA Clone for CCL22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL22 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCL22
    Search LifeMap BioReagents cell lines for CCL22

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL22

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--


    CCL22 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ccl22):
     nervous system 

    CCL22 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCL22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL22 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    5/6        Reactome Pathways for CCL22 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for CCL22):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL22 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CCL22 (O006262, 3 ENSP000002192354) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091012 I2D: score=3 STRING: ENSP00000353731
    CCL19Q997313, ENSP000003088154I2D: score=3 STRING: ENSP00000308815
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    CCR7P322483, ENSP000002466574I2D: score=1 STRING: ENSP00000246657
    VCAM1P193203, ENSP000002947284I2D: score=4 STRING: ENSP00000294728
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS9151897
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9743322
    GO:0007267cell-cell signaling TAS9151897


    CCL22 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCL22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL22 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL22
    10/23 Novoseek chemical compound relationships for CCL22 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 98 262 9430724 (9), 12645858 (9), 15813816 (7), 12715916 (6) (see all 87)
    ccl3 81.8 16 15256380 (2), 12534281 (1), 14657379 (1), 16905241 (1) (see all 13)
    rantes 78 34 16343773 (3), 10961862 (2), 17460400 (2), 11238053 (2) (see all 23)
    ccl4 58 10 14657379 (1), 16905241 (1), 17369706 (1), 14747532 (1) (see all 9)
    larc 55.6 2 11001915 (1), 11792124 (1)
    sb 203580 20.7 3 16761312 (1), 17617806 (1)
    pertussis 17.4 1 15167983 (1)
    adp 15.4 10 11172816 (2), 15054038 (2), 11159520 (1), 10891429 (1)
    calcium 9.46 31 15167983 (4), 10069890 (3), 11248289 (3), 9430724 (3) (see all 10)
    leukotriene b4 3.64 4 16055623 (2)

    Search CenterWatch for drugs/clinical trials and news about CCL22 

    Transcripts
    for CCL22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCL22 gene: 
    NM_002990.4  

    Unigene Cluster for CCL22:

    Chemokine (C-C motif) ligand 22
    Hs.534347  [show with all ESTs]
    Unigene Representative Sequence: NM_002990
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000219235(uc002elh.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCL22
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL22
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL22 (see all 27):
    hsa-miR-194* hsa-miR-4254 hsa-miR-4251 hsa-miR-3614-3p hsa-miR-765 hsa-miR-374a hsa-miR-1285 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CCL22 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL22 (see all 7)
    OriGene shRNA RFP: CCL22
    OriGene siRNA: CCL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL22
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL22 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL22
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL22 (NM_002990)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL22 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL22

    Additional cDNA sequence: 

    AK311970.1 BC027952.1 U83171.1 U83239.1 

    2 DOTS entries:

    DT.403562  DT.120667567 

    19 AceView cDNA sequences:

    BX279647 BG235968 NM_002990 AA907433 BM977006 BV198323 AV713579 BI521552 
    CA430446 BV186568 BC027952 U83171 U83239 BV198324 CD698350 CD708976 
    CD703658 CD710019 CD705857 

    GeneLoc Exon Structure


    Expression
    for CCL22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACGGGGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCL22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL22

    SOURCE GeneReport for Unigene cluster: Hs.534347

    UniProtKB/Swiss-Prot: CCL22_HUMAN, O00626
    Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in
    lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen.
    Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and
    CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic
    dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL22 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL22
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL22

    Orthologs
    for CCL22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL22 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ccl221 , 5 chemokine (C-C motif) ligand 221, 5 73.55(n)1
    63.04(a)1    		   8 (46.75 cM)5
    202991  NM_009137.21  NP_033163.11 
     947455905 


    ENSEMBL Gene Tree for CCL22 (if available)
    TreeFam Gene Tree for CCL22 (if available) 

    Paralogs
    for CCL22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CCL22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 NCBI SNPs in CCL22 are shown (see all 214)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2022186391,2
    		--57390787(+) CAACG-/ACAACAAC 1 -- us2k10--------
    rs1423508011,2
    		--57390827(+) ACATCC/TGCAAA 1 -- us2k10--------
    rs348854821,2
    		C,F,--57390934(+) TAAATG/ATTTGC 1 -- us2k15Minor allele frequency- A:0.24NA EA 246
    rs727848941,2
    		C,F,--57390954(+) GAATTG/TGATGA 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs1830643091,2
    		--57391145(+) GGACTC/TTCATT 1 -- us2k10--------
    rs2238871,2
    		C,F,A,H,--57391214(+) CACCGT/GATTCA 1 -- us2k110Minor allele frequency- G:0.44NA WA CSA EA 369
    rs1875348221,2
    		--57391248(+) CCCCAA/GGTAGC 1 -- us2k10--------
    rs1920168331,2
    		--57391267(+) CAGGCG/TCATGC 1 -- us2k10--------
    rs713871621,2
    		C,F,--57391270(+) GCGCAT/AGCCAT 1 -- us2k14Minor allele frequency- A:0.12NA EA 244
    rs713871631,2
    		C,F,--57391273(+) CATGCC/GATCAC 1 -- us2k14Minor allele frequency- G:0.12NA EA 244

    HapMap Linkage Disequilibrium report for CCL22 (57392684 - 57400102 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCL22: --
    Human Gene Mutation Database (HGMD): CCL22

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL22
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL22

    Disorders / Diseases
    for CCL22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCL22 for disorders           About GeneDecksing

    OMIM gene information: 602957    OMIM disorders: --

    20/68 diseases for CCL22 (see all 68):    About MalaCards
    toxic epidermal necrolysis    stevens-johnson syndrome    langerhans-cell histiocytosis    human t-cell leukemia virus type 1
    allergic bronchopulmonary aspergillosis    mycosis fungoides    allergic contact dermatitis    contact dermatitis
    vernal keratoconjunctivitis    erythema multiforme    necatoriasis    amyotrophic lateral sclerosis
    pulmonary fibrosis    idiopathic pulmonary fibrosis    lateral sclerosis    dermatitis
    eosinophilic pneumonia    cystic fibrosis    keratoconjunctivitis    allergic rhinitis

    2 diseases from the University of Copenhagen DISEASES database for CCL22:
    Atopic dermatitis     Asthma

    10/33 Novoseek disease relationships for CCL22 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 71.5 17 10602042 (2), 12715916 (2), 15813816 (2), 18266834 (2) (see all 11)
    inflammation 50 19 15993846 (2), 17617806 (2), 18451325 (1), 20170340 (1) (see all 14)
    pulmonary fibrosis 49.4 8 15383605 (3), 19715610 (2), 15293604 (1), 15993846 (1)
    fibrosis idiopathic pulmonary 47.9 6 15293604 (3), 19715610 (1)
    mycosis fungoides 47 2 10602042 (1), 15927812 (1)
    asthma 46.6 14 12645858 (3), 16393265 (2), 12925672 (1), 14616122 (1) (see all 10)
    pneumonia eosinophilic 43.3 1 12757454 (1)
    necrosis 34.1 17 9581805 (2), 11483776 (1), 11923841 (1), 11001915 (1) (see all 13)
    bronchoalveolar lavage fluid 30.6 4 12757454 (2), 15293604 (1), 15751278 (1)
    skin lesion 26.4 4 11241286 (1), 17071491 (1), 16583210 (1), 18266834 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCL22 (7 documents)

    Export disorders for CCL22 gene to outside databases

    Publications
    for CCL22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL22 gene, integrated from 9 sources (see all 285):
    (articles sorted by number of sources associating them with CCL22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. (PubMed id 9151897)1, 2, 3, 9 Godiska R.... Gray P.W. (1997)
    2. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)1, 2, 9 Imai T.... Gray P.W. (1998)
    3. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. (PubMed id 11241286)1, 2, 9 Vulcano M.... Sozzani S. (2001)
    4. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. (PubMed id 9312138)1, 2, 9 Chang M.-S.... Andrew D.P. (1997)
    5. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. (PubMed id 9691168)1, 3, 9 Nomiyama H....Yoshie O. (1998)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    8. Cord blood cytokines and chemokines and development o f allergic disease. (PubMed id 19175890)1, 9 Sandberg M....Jenmalm M.C. (2009)
    9. Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. (PubMed id 14747532)1, 9 Nakayama T....Yoshie O. (2004)
    10. CCL22 is involved in the recruitment of CD4+CD25 high T cells into tuberculous pleural effusions. (PubMed id 20337996)1, 9 Wu C....Shi H.Z. (2010)

    External Searches for CCL22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCL22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6367 HGNC: 10621 AceView: CCL22 Ensembl:ENSG00000102962 euGenes: HUgn6367
    ECgene: CCL22 Kegg: 6367 H-InvDB: CCL22

    Other Databases showing CCL22 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCL22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL22 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL22

    Intellectual Property
    for CCL22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCL22 gene:
    Search GeneIP for patents involving CCL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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