Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL21 Gene

Aliases for CCL21 Gene

  • Chemokine (C-C Motif) Ligand 21 2 3
  • SCYA21 3 4 6
  • SLC 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 21 2 3
  • Efficient Chemoattractant For Lymphocytes 2 3
  • Secondary Lymphoid Tissue Chemokine 2 3
  • Beta Chemokine Exodus-2 2 3
  • 6Ckine 3 4
  • Secondary Lymphoid-Tissue Chemokine 4
  • Small-Inducible Cytokine A21 4
  • Beta-Chemokine Exodus-2 4
  • C-C Motif Chemokine 21 3
  • CKb9 3
  • TCA4 3
  • ECL 3

External Ids for CCL21 Gene

Previous Symbols for CCL21 Gene

  • SCYA21

Summaries for CCL21 Gene

Entrez Gene Summary for CCL21 Gene

  • This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL21 Gene

CCL21 (Chemokine (C-C Motif) Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include chronic lymphocytic leukemia and thymic hyperplasia. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity and CCR7 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL21 Gene

  • Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

Gene Wiki entry for CCL21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL21 Gene

Genomics for CCL21 Gene

Genomic Location for CCL21 Gene

Start:
34,709,005 bp from pter
End:
34,710,167 bp from pter
Size:
1,163 bases
Orientation:
Minus strand

Genomic View for CCL21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL21 Gene

Regulatory Elements for CCL21 Gene

Proteins for CCL21 Gene

  • Protein details for CCL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00585-CCL21_HUMAN
    Recommended name:
    C-C motif chemokine 21
    Protein Accession:
    O00585
    Secondary Accessions:

    Protein attributes for CCL21 Gene

    Size:
    134 amino acids
    Molecular mass:
    14646 Da
    Quaternary structure:
    • Monomer. Binds to CCR7.

    Three dimensional structures from OCA and Proteopedia for CCL21 Gene

neXtProt entry for CCL21 Gene

Proteomics data for CCL21 Gene at MOPED

Post-translational modifications for CCL21 Gene

No Post-translational modifications

Other Protein References for CCL21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL21 Gene

Domains for CCL21 Gene

Gene Families for CCL21 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL21 Gene

UniProtKB/Swiss-Prot:

CCL21_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • O00585
genes like me logo Genes that share domains with CCL21: view

Function for CCL21 Gene

Molecular function for CCL21 Gene

UniProtKB/Swiss-Prot Function: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

Gene Ontology (GO) - Molecular Function for CCL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 15778365
GO:0031732 CCR7 chemokine receptor binding ISS --
GO:0042379 chemokine receptor binding IDA 23341447
genes like me logo Genes that share ontologies with CCL21: view

Phenotypes for CCL21 Gene

genes like me logo Genes that share phenotypes with CCL21: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL21 Gene

Localization for CCL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL21 Gene COMPARTMENTS Subcellular localization image for CCL21 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL21: view

Pathways for CCL21 Gene

genes like me logo Genes that share pathways with CCL21: view

Gene Ontology (GO) - Biological Process for CCL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IDA 12729902
GO:0001771 immunological synapse formation ISS --
GO:0001954 positive regulation of cell-matrix adhesion IDA 15569314
GO:0002407 dendritic cell chemotaxis IDA 15778365
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
genes like me logo Genes that share ontologies with CCL21: view

Compounds for CCL21 Gene

(9) Novoseek inferred chemical compound relationships for CCL21 Gene

Compound -log(P) Hits PubMed IDs
mip-3beta 84.5 2
teck 75.2 5
larc 70.7 5
ccl3 62.1 4
tarc 58.1 4
genes like me logo Genes that share compounds with CCL21: view

Transcripts for CCL21 Gene

mRNA/cDNA for CCL21 Gene

Unigene Clusters for CCL21 Gene

Chemokine (C-C motif) ligand 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for CCL21 Gene

GeneLoc Exon Structure for
CCL21
ECgene alternative splicing isoforms for
CCL21

Expression for CCL21 Gene

mRNA expression in normal human tissues for CCL21 Gene

mRNA differential expression in normal tissues according to GTEx for CCL21 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (11.1) and Thyroid (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCL21 Gene

SOURCE GeneReport for Unigene cluster for CCL21 Gene Hs.57907

mRNA Expression by UniProt/SwissProt for CCL21 Gene

O00585-CCL21_HUMAN
Tissue specificity: Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen
genes like me logo Genes that share expressions with CCL21: view

Orthologs for CCL21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL21 36
  • 100 (n)
  • 100 (a)
CCL21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL21 36
  • 83.97 (n)
  • 72.52 (a)
CCL21 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL21 36
  • 87.22 (n)
  • 79.7 (a)
mouse
(Mus musculus)
Mammalia Ccl21a 37
  • 71 (a)
OneToMany
CCL21A 37
  • 71 (a)
OneToMany
Ccl21b 16
Ccl21b 37
  • 71 (a)
OneToMany
Ccl21c 37
  • 71 (a)
OneToMany
Ccl21c 37
  • 71 (a)
OneToMany
Ccl21c 37
  • 71 (a)
OneToMany
Gm10591 37
  • 71 (a)
OneToMany
Gm13304 37
  • 71 (a)
OneToMany
Gm21541 36
  • 79.95 (n)
  • 71.43 (a)
Gm21541 37
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCL21 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCL21 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl21 36
  • 79.17 (n)
  • 70.31 (a)
Species with no ortholog for CCL21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL21 Gene

ENSEMBL:
Gene Tree for CCL21 (if available)
TreeFam:
Gene Tree for CCL21 (if available)

Paralogs for CCL21 Gene

Selected SIMAP similar genes for CCL21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL21: view

No data available for Paralogs for CCL21 Gene

Variants for CCL21 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL21 Gene

Variant ID Type Subtype PubMed ID
nsv831544 CNV Gain 17160897
nsv893040 CNV Gain 21882294
nsv509301 CNV Insertion 20534489

Relevant External Links for CCL21 Gene

HapMap Linkage Disequilibrium report
CCL21

No data available for Sequence variations from dbSNP and Humsavar for CCL21 Gene

Disorders for CCL21 Gene

(18) Novoseek inferred disease relationships for CCL21 Gene

Disease -log(P) Hits PubMed IDs
sjogrens syndrome 25.8 1
tumors 25.4 15
melanoma b16 23.5 1
inflammation 21.9 7
autoimmune diseases 20.9 2

Relevant External Links for CCL21

Genetic Association Database (GAD)
CCL21
Human Genome Epidemiology (HuGE) Navigator
CCL21
genes like me logo Genes that share disorders with CCL21: view

No data available for UniProtKB/Swiss-Prot for CCL21 Gene

Publications for CCL21 Gene

  1. Molecular cloning of a novel human CC chemokine secondary lymphoid- tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. (PMID: 9235955) Nagira M. … Yoshie O. (J. Biol. Chem. 1997) 2 3 4 23
  2. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. (PMID: 9419363) Gunn M.D. … Williams L.T. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. (PMID: 9507024) Yoshida R. … Yoshie O. (J. Biol. Chem. 1998) 3 4 23
  4. Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. (PMID: 10706668) Gosling J. … Schall T.J. (J. Immunol. 2000) 3 23
  5. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. (PMID: 10861057) Annunziato F. … Romagnani S. (J. Immunol. 2000) 3 23

Products for CCL21 Gene

  • Addgene plasmids for CCL21

Sources for CCL21 Gene

Back to Top

Content