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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL21 Gene

protein-coding   GIFtS: 63
GCID: GC09M034709

Chemokine (C-C Motif) Ligand 21

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 21)
(Previous symbol: SCYA21)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 211 2     CKb92
SCYA211 2 3 5     ECL2
SLC2 3 5     TCA42
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 211 2     C-C Motif Chemokine 212
Beta Chemokine Exodus-21 2     Beta-Chemokine Exodus-23
Efficient Chemoattractant For Lymphocytes1 2     Secondary Lymphoid-Tissue Chemokine3
Secondary Lymphoid Tissue Chemokine1 2     Small-Inducible Cytokine A213
6Ckine2 3     

External Ids:    HGNC: 106201   Entrez Gene: 63662   Ensembl: ENSG000001370777   OMIM: 6027375   UniProtKB: O005853   

Export aliases for CCL21 gene to outside databases

Previous GC identifers: GC09M035021 GC09M034878 GC09M034699 GC09M034663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL21 Gene:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits
hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells,
but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in
mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for
chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the
cytokine family (small inducible cytokine A19). (provided by RefSeq, May 2013)

GeneCards Summary for CCL21 Gene: 
CCL21 (chemokine (C-C motif) ligand 21) is a protein-coding gene. Diseases associated with CCL21 include chronic inflammatory demyelinating polyradiculoneuropathy, and gastric lymphoma, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and LT-BetaR Pathway. GO annotations related to this gene include CCR7 chemokine receptor binding and chemokine activity.

UniProtKB/Swiss-Prot: CCL21_HUMAN, O00585
Function: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated
T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May
play a role in mediating homing of lymphocytes to secondary lymphoid organs

Gene Wiki entry for CCL21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL21 gene promoter:
         p53   p300   IRF-1   HNF-3beta   Ik-3   E47   GATA-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL21 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

CCL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL21 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034709:  view genomic region     (about GC identifiers)

Start:
34,709,002 bp from pter      End:
34,710,147 bp from pter
Size:
1,146 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL21_HUMAN, O00585 (See protein sequence)
Recommended Name: C-C motif chemokine 21 precursor  
Size: 134 amino acids; 14646 Da
Subunit: Monomer. Binds to CCR7
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CCL21:
2L4N (3D)    

Explore the universe of human proteins at neXtProt for CCL21: NX_O00585

Explore proteomics data for CCL21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00585

  • CCL21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL21 Protein Expression
    REFSEQ proteins: NP_002980.1  
    ENSEMBL proteins: 
     ENSP00000259607   ENSP00000368069  
    Reactome Protein details: O00585
    Human Recombinant Protein Products for CCL21: 
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    OriGene MassSpec for CCL21 
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    GenScript Purified and Recombinant Proteins for CCL21
    Novus Biologicals CCL21 Proteins
    Novus Biologicals CCL21 Lysates
    Sino Biological Recombinant Protein for CCL21
    Sino Biological Cell Lysate for CCL21 
    ProSpec Recombinant Protein for CCL21
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL21 for ontologies           About GeneDecksing



    CCL21 Antibody Products: 
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    Novus Biologicals CCL21 Antibodies
    Abcam antibodies for CCL21
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    Assay Products for CCL21: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for CCL21 (CCL21/6Ckine)         (see all)
    GenScript Custom Assay Services for CCL21
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    1 InterPro protein domain:
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry O00585

    ProtoNet protein and cluster: O00585

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL21_HUMAN, O00585
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL21_HUMAN, O00585
    Function: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated
    T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May
    play a role in mediating homing of lymphocytes to secondary lymphoid organs

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA15778365
    GO:0031732CCR7 chemokine receptor binding ISS--
         
    CCL21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL21:
     Decreased G3BP1 protein expres 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL21 

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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL21:
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    SwitchGear 3'UTR luciferase reporter plasmidCCL21 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Sirion Biotech Customized adenovirus for overexpression of CCL21

    Clone
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    OriGene ORF clones in mouse, rat for CCL21
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    GenScript: all cDNA clones in your preferred vector: CCL21 (NM_002989)
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                         Customized lentivirus expression plasmids for stable overexpression of CCL21 

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    Search LifeMap BioReagents cell lines for CCL21
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL21 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL21
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL21 (see all 28)
        LT-BetaR Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions

    1 GeneGo (Thomson Reuters) Pathway for CCL21
        Apoptosis and survival Lymphotoxin-beta receptor signaling


    5/8        Reactome Pathways for CCL21 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCL21):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway


    CCL21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for CCL21 (O005852, 3 ENSP000002596074) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2862960 I2D: score=3 STRING: ENSP00000357292
    GOT2P005052, 3, ENSP000002452064MINT-8250756 I2D: score=2 STRING: ENSP00000245206
    ACKR4Q9NPB93, ENSP000002498874I2D: score=3 STRING: ENSP00000249887
    CCR7P322483, ENSP000002466574I2D: score=3 STRING: ENSP00000246657
    IGFBP7Q162703, ENSP000002956664I2D: score=3 STRING: ENSP00000295666
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001768establishment of T cell polarity IDA12729902
    GO:0001771immunological synapse formation ISS--
    GO:0001954positive regulation of cell-matrix adhesion IDA15569314
    GO:0002407dendritic cell chemotaxis IDA15778365
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--

    CCL21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL21 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL21

    9 Novoseek inferred chemical compound relationships for CCL21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mip-3beta 84.5 2 12437666 (2)
    teck 75.2 5 10706668 (3), 9886241 (1), 10967023 (1)
    larc 70.7 6 9365118 (2), 10027395 (2), 10967023 (1)
    ccl3 62.1 5 15818740 (1), 12651610 (1), 16106219 (1), 19726994 (1)
    tarc 58.1 5 9365118 (2), 15890946 (2)
    rantes 48.7 7 15818740 (1), 12847218 (1), 15233729 (1), 12667214 (1) (see all 5)
    ccl4 31.9 5 12651610 (1), 16106219 (1), 18250572 (1), 19726994 (1)
    pge2 24.4 5 19545899 (1), 12149218 (1)
    calcium 0 6 9507024 (3), 10339465 (2), 15956285 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL21 gene: 
    NM_002989.3  

    Unigene Cluster for CCL21:

    Chemokine (C-C motif) ligand 21
    Hs.57907  [show with all ESTs]
    Unigene Representative Sequence: BI838628
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259607(uc003zvo.3) ENST00000378792
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL21:
    hsa-miR-370 hsa-miR-331-5p hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidCCL21 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL21

    Additional mRNA sequence: 

    AB002409.1 AF001979.1 AK311901.1 AY358887.1 BC027918.1 CR450326.1 U88320.1 

    2 DOTS entries:

    DT.414858  DT.100748260 

    24/118 AceView cDNA sequences (see all 118):

    BI838571 CB164244 AA234005 AI185579 AI707832 AI718256 AI707973 AI719947 
    AI253757 BM704701 BI834167 AI571892 NM_002989 CR615435 AA331228 AI224371 
    CR450326 BC027918 AI718192 CF530057 AI253634 BI837774 BE501196 AA360212 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL21    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for CCL21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGAGGCA
    CCL21 Expression
    About this image


    See CCL21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL21

    SOURCE GeneReport for Unigene cluster: Hs.57907

    UniProtKB/Swiss-Prot: CCL21_HUMAN, O00585
    Tissue specificity: Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate
    levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver,
    and pancreas. Also found in tonsil, fetal heart and fetal spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL21: 
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL21 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl21b5
    Gm105911
    chemokine (C-C motif) ligand 21B (leucine)5
    predicted gene 105911
    79.95(n)1
    71.43(a)1
      4 (22.12 cM)5
    1005042391  NM_001193668.11  NP_001180597.11 
     422557675 
    chicken
    (Gallus gallus)
    Aves CCL196
    Uncharacterized protein
    37(a)
    1 → many
    Z(8222635-8225085)


    ENSEMBL Gene Tree for CCL21 (if available)
    TreeFam Gene Tree for CCL21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL21 gene
    18/20 SIMAP similar genes for CCL21 using alignment to 3 protein entries:     CCL21_HUMAN (see all proteins) (see all similar genes):
    CCL16    CCL3L1    CCL3L3    CCL19    CCL14    CCL20
    CCL26    CCL3    CCL22    CCL4    CCL4L2    LOC728835
    CCL18    CCL4L1    CCL11    CCL8    CCL5    CCL7

    CCL21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 SNPs in CCL21 are shown (see all 109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439033641,2
    C--34708506(+) CAGGGC/TTGGAA 1 -- ds50010--------
    rs1483731981,2
    --34708611(+) CACTTA/GGAGGG 1 -- ds50010--------
    rs1858990821,2
    --34708898(+) TAGATG/TAGAAC 1 -- ds50010--------
    rs109722031,2
    C,F,A,H--34708899(-) TGTTCT/CCATCT 1 -- ds500130Minor allele frequency- C:0.13NA NS EA CSA WA 3050
    rs109722041,2
    C,F,H--34708946(-) GGTGGG/AGTCAC 1 -- ds500118Minor allele frequency- A:0.14NA NS EA CSA WA 2138
    rs1415929521,2
    --34708961(+) AGGAAA/CCTTGG 1 -- ds50010--------
    rs1910587241,2
    --34709039(+) GTTAGA/GTATAA 1 -- ut310--------
    rs18019371,2
    C,F--34709060(-) CCTCTT/GCCTTG 1 -- ut312Minor allele frequency- G:0.07NA WA 162
    rs1475426251,2
    --34709238(+) AGATGA/GGGTGG 1 -- ut310--------
    rs115749161,2
    C,F,H--34709239(-) ACCACC/TCCATC 1 -- ut31 ese311Minor allele frequency- T:0.04NA NS EA WA 1296

    HapMap Linkage Disequilibrium report for CCL21 (34709002 - 34710147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCL21:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509301CNV Insertion20534489
    nsv893040CNV Gain21882294
    nsv831544CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602737    OMIM disorders: --

    20/56 diseases for CCL21 (see all 56):    About MalaCards
    chronic inflammatory demyelinating polyradiculoneuropathy    gastric lymphoma    central nervous system lymphoma    inclusion body myositis
    proliferative vitreoretinopathy    allergic contact dermatitis    contact dermatitis    polyradiculoneuropathy
    guillain-barre syndrome    idiopathic pulmonary fibrosis    common variable immunodeficiency    myositis
    wegener's granulomatosis    psoriatic arthritis    malt lymphoma    adult t-cell leukemia
    sjogren's syndrome    spinal cord injury    myasthenia gravis    hiv type 1


    CCL21 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for CCL21 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sjogrens syndrome 25.8 1 18354239 (1)
    tumors 25.4 15 14613584 (2), 14726959 (1), 15059899 (1), 17016763 (1) (see all 14)
    melanoma b16 23.5 1 16112911 (1)
    inflammation 21.9 8 17982129 (1), 16118351 (1), 19747210 (1), 11943728 (1) (see all 7)
    autoimmune diseases 20.9 2 12393410 (1), 16887149 (1)
    metastasis 14.4 4 20181250 (2), 17891505 (1)
    necrosis 12.4 4 12186835 (1), 16106219 (1), 17223654 (1), 16618517 (1)
    atherosclerotic plaque 12.3 1 10027395 (1)
    cancer 5.06 3 14613584 (1), 16112911 (1), 15671487 (1)
    multiple sclerosis 3.92 2 12576236 (1)

    Genetic Association Database (GAD): CCL21
    Human Genome Epidemiology (HuGE) Navigator: CCL21 (20 documents)

    Export disorders for CCL21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL21 gene, integrated from 9 sources (see all 214):
    (articles sorted by number of sources associating them with CCL21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human CC chemokine secondary lymphoid- tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. (PubMed id 9235955)1, 2, 3, 9 Nagira M.... Yoshie O. (1997)
    2. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. (PubMed id 9507024)1, 2, 9 Yoshida R.... Yoshie O. (1998)
    3. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. (PubMed id 9419363)1, 2, 9 Gunn M.D....Williams L.T. (1998)
    4. Solution structure of CCL21 and identification of a putative CCR7 binding site. (PubMed id 22221265)1, 2 Love M.... Veldkamp C.T. (2012)
    5. Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. (PubMed id 20797713)1, 4 Sundqvist J....D'Hooghe T.M. (2011)
    6. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PubMed id 19674979)1, 4 Hinks A....Packham J. (2010)
    7. Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthrit is patients. (PubMed id 20461788)1, 4 Farragher T.M....Barton A. (2010)
    8. A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. (PubMed id 20049410)1, 4 Wieczorek S....Epplen J.T. (2010)
    9. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-t umour necrosis factor treatment. (PubMed id 20444755)1, 4 Tan R.J....Barton A. (2010)
    10. Genetic variants in the prediction of rheumatoid arth ritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6366 HGNC: 10620 AceView: CCL21 Ensembl:ENSG00000137077 euGenes: HUgn6366
    ECgene: CCL21 Kegg: 6366 H-InvDB: CCL21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL21 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL21

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL21 gene:
    Search GeneIP for patents involving CCL21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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