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CCL20 Gene

protein-coding   GIFtS: 65
GCID: GC02P228678

Chemokine (C-C Motif) Ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 2...)
(Previous symbol: SCYA20)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 201 2     MIP-3-alpha2 3
SCYA201 2 3 5     CC Chemokine LARC2 3
LARC2 3 5     CKb42
MIP3A2 3 5     MIP-3a2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 201 2     ST382
Liver And Activation-Regulated Chemokine2 3     Beta Chemokine Exodus-12
Macrophage Inflammatory Protein 3 Alpha2 3     C-C Motif Chemokine 202
Small-Inducible Cytokine A202 3     Beta-Chemokine Exodus-13

External Ids:    HGNC: 106191   Entrez Gene: 63642   Ensembl: ENSG000001150097   OMIM: 6019605   UniProtKB: P785563   
ORGUL members:         

Export aliases for CCL20 gene to outside databases

Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCL20 Gene:
CCL20 (chemokine (C-C motif) ligand 20) is a protein-coding gene. Diseases associated with CCL20 include hordeolum, and smallpox. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
activity E.coli ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL20 gene promoter:
         HFH-3   Pax-5   Nkx2-2   NF-kappaB   E47   C/EBPalpha   FOXI1   Chx10   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL20 promoter sequence
   Search Chromatin IP Primers for CCL20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P228678:  view genomic region     (about GC identifiers)

Start:
228,678,558 bp from pter      End:
228,682,280 bp from pter
Size:
3,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)
Recommended Name: C-C motif chemokine 20 precursor  
Size: 96 amino acids; 10762 Da
Subunit: Binds to and activate CCR6
3 PDB 3D structures from and Proteopedia for CCL20:
1M8A (3D)        2HCI (3D)        2JYO (3D)    
Secondary accessions: Q53S51 Q99664
Alternative splicing: 2 isoforms:  P78556-1   P78556-2   

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Explore proteomics data for CCL20 at MOPED

Post-translational modifications: 

  • C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion
    from peripheral blood monocytes1
  • Modification sites at neXtProt

  • See CCL20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123518.1  NP_004582.1  

    ENSEMBL proteins: 
     ENSP00000386273   ENSP00000351671  
    Reactome Protein details: P78556

    CCL20 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CCL20
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL20
    GenScript Purified and Recombinant Proteins for CCL20
    Novus Biologicals CCL20 Proteins
    Novus Biologicals CCL20 Lysates
    Sino Biological Recombinant Protein for CCL20
    Sino Biological Cell Lysate for CCL20
    ProSpec Recombinant Protein for CCL20
    Browse Proteins at Cloud-Clone Corp.

    CCL20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CCL20 Antibodies
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    ThermoFisher Antibodies for CCL20
    LSBio Antibodies in human, mouse, rat for CCL20

    CCL20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha)         (see all)
    GenScript Custom Assay Services for CCL20
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P78556

    ProtoNet protein and cluster: P78556

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL20_HUMAN, P78556
    Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
    proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
    mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
    processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
    activity E.coli ATCC 25922 and S.aureus ATCC 29213
    Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate
    (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005515protein binding IPI17703191
    GO:0008009chemokine activity IEA--
         
    CCL20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL20:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL20

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL20:
    hsa-mir-335-5p (MIRT017837), hsa-mir-21-5p (MIRT006199)

    Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CCL20:
    hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidCCL20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL20
    Predesigned siRNA for gene silencing in human, mouse, rat CCL20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL20

    Clone
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    OriGene clones in human, mouse for CCL20 (see all 11)
    OriGene ORF clones in mouse, rat for CCL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
    Sino Biological Human cDNA Clone for CCL20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL20_HUMAN, P78556: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL20 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Immune response Bacterial infections in normal airways
    Bacterial infections in CF airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL20
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL20 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL20
        Immune response TLR signaling pathways
    Bacterial infections in CF airways

    1 BioSystems Pathway for CCL20
        EBV LMP1 signaling


    2 Reactome Pathways for CCL20
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    4 Kegg Pathways  (Kegg details for CCL20):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway
    Rheumatoid arthritis


    CCL20 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL20 (see all 8): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL20 (P785561, 2, 3 ENSP000003516714) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K32, 3MINT-6505246 I2D: score=1 
    RALBP1Q153111, 2, 3, ENSP000000193174EBI-3913209,EBI-749285 MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
    CCR6P516843, ENSP000003393934I2D: score=3 STRING: ENSP00000339393
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CTSBP078583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10438902
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9038201
    GO:0007267cell-cell signaling TAS9038201

    CCL20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL20

    Selected Novoseek inferred chemical compound relationships for CCL20 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    larc 95.7 108 9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
    mip-3alpha 86.4 9 15069060 (7), 11352563 (1), 17928889 (1)
    tarc 76.2 12 9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
    ccl3 76.1 11 18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
    rantes 68.8 25 18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
    ccl4 60 15 18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
    flagellin 51.8 8 15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
    il-12 43.4 1 15860229 (1)
    poly(i-c) 33 1 16911361 (1)
    imac 32 7 16034074 (4)



    CCL20 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCL20 gene (2 alternative transcripts): 
    NM_001130046.1  NM_004591.2  

    Unigene Cluster for CCL20:

    Chemokine (C-C motif) ligand 20
    Hs.75498  [show with all ESTs]
    Unigene Representative Sequence: BC020698
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813
    ENST00000473642
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CCL20:
    hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidCCL20 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20
    Primer
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    OriGene qPCR primer pairs and template standards for CCL20
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL20
      QuantiTect SYBR Green Assays in human, mouse, rat CCL20
      Search QuantiFast Probe-based Assays in human, mouse, rat CCL20

    Additional mRNA sequence: 

    BC020698.1 D86955.1 U64197.1 U77035.1 

    5 DOTS entries:

    DT.211225  DT.95102901  DT.100777315  DT.91717429  DT.100777317 

    Selected AceView cDNA sequences (see all 76):

    BM833314 D17012 AA983599 D17181 AW965098 AA297433 AW168095 CD365673 
    CD641783 CD523297 AW072796 BM956130 AA527293 U77035 AW014484 BG563672 
    AU185348 AI285199 BE439997 D86955 BM955557 BG950969 AW084987 BC020698 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:              -                     
    SP2:              -                     
    SP3:                                    


    ECgene alternative splicing isoforms for CCL20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTTTAG
    CCL20 Expression
    About this image


    CCL20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Colon (Gastrointestinal Tract)
     
     Tonsil (Hematopoietic System)
    CCL20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75498

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and
    fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL20 (see first 5): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Antifungal Response in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CCL20
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    QuantiTect SYBR Green Assays in human, mouse, rat CCL20
    Search QuantiFast Probe-based Assays in human, mouse, rat CCL20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL20 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl201 , 5 chemokine (C-C motif) ligand 201, 5 72.7(n)1
    63.83(a)1
      1 (42.69 cM)5
    202971  NM_016960.21  NP_058656.11 
     831167665 
    chicken
    (Gallus gallus)
    Aves CCL201 chemokine (C-C motif) ligand 20 61.96(n)
    56.52(a)
      395082  NM_204438.2  NP_989769.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCL206
    chemokine (C-C motif) ligand 20
    47(a)
    1 ↔ 1
    3(23292927-23296252)


    ENSEMBL Gene Tree for CCL20 (if available)
    TreeFam Gene Tree for CCL20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL20 gene
    18 SIMAP similar genes for CCL20 using alignment to 1 protein entry:     CCL20_HUMAN:
    CCL16    CCL26    CCL2    CCL21    CCL11    CCL18
    CCL23    CCL3    CCL4    CCL3L1    CCL3L3    CCL5
    CCL7    MCP-3    CCL8    CCL24    IL8    LOC728835

    CCL20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL20 (see all 168)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838241781,2
    --228676559(+) GTTGGC/TCAGGT 2 -- us2k10--------
    rs784997631,2
    C,F--228676591(+) CGGCTC/TGCCGT 2 -- us2k11Minor allele frequency- T:0.08EA 120
    rs101796001,2
    C,F,H--228676594(+) ctcgcC/Tgtaac 2 -- us2k113Minor allele frequency- T:0.35NS EA NA WA CSA 784
    rs1460017321,2
    --228676769(+) CACCTC/TGGCCT 2 -- us2k10--------
    rs1892745961,2
    C--228676770(+) ACCTCA/GGCCTC 2 -- us2k10--------
    rs1486805811,2
    --228676796(+) TACAGG/TCATGA 2 -- us2k10--------
    rs1150855381,2
    C,F--228676856(+) CTTTCT/CGTCTG 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs621900051,2
    C--228676922(+) CAGTCG/AGTTTA 2 -- us2k15Minor allele frequency- A:0.24NA WA EA 362
    rs1925789321,2
    --228676974(+) CCTAGA/GGAACA 2 -- us2k10--------
    rs1851337991,2
    --228676976(+) TAGAGA/TACATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv10221CNV Loss18304495
    nsv834562CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL20
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601960    OMIM disorders: --

    Selected diseases for CCL20 (see all 69):    
    About MalaCards
    hordeolum    smallpox    stromal keratitis    pustulosis palmaris et plantaris
    obstructive jaundice    middle ear cholesteatoma    keratitis    periodontal disease
    peripheral t-cell lymphoma    acute liver failure    intrauterine infections    cholesteatoma
    endometrial adenocarcinoma    vaginitis    vaccinia    inflammatory bowel disease
    viral hepatitis    periodontitis    psoriasis    atopic dermatitis

    2 diseases from the University of Copenhagen DISEASES database for CCL20:
    Psoriasis     Inflammatory bowel disease

    CCL20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CCL20 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 57.2 25 17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
    necrosis 56.7 34 16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
    inflammatory bowel diseases 49.3 11 12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
    psoriasis 48.2 14 15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
    tumors 38.9 63 19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
    dermatitis atopic 35.6 2 11133838 (1), 17369706 (1)
    rheumatoid arthritis 34.1 10 19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
    colitis ulcerative 30.1 4 12427784 (2), 16306769 (1), 18340639 (1)
    pathological processes 22.7 1 12356943 (1)
    skin lesion 19.9 2 15315355 (1), 19659772 (1)

    Genetic Association Database (GAD): CCL20
    Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

    Export disorders for CCL20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL20 gene, integrated from 10 sources (see all 360):
    (articles sorted by number of sources associating them with CCL20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)1, 2, 3, 9 Hieshima K.... Nomiyama H. (J. Biol. Chem. 1997)
    2. Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)1, 2, 3, 9 Nelson R.T.... McColl S.R. (Genomics 2001)
    3. The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)1, 2, 9 Hoover D.M....Lubkowski J. (J. Biol. Chem. 2002)
    4. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)1, 2, 9 Schutyser E.... Van Damme J. (J. Immunol. 2000)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)1, 4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6364 HGNC: 10619 AceView: CCL20 Ensembl:ENSG00000115009 euGenes: HUgn6364
    ECgene: CCL20 Kegg: 6364 H-InvDB: CCL20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL20 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL20

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL20 gene:
    Search GeneIP for patents involving CCL20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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