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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL20 Gene

protein-coding GIFtS: 62
GCID: GC02P228678

chemokine (C-C motif) ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA20)

Explore 71 diseases affiliated with
CCL20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 20¹ ²		Macrophage Inflammatory Protein 3 Alpha² ³
LARC¹ ² ³ ⁵		Small-Inducible Cytokine A20² ³
SCYA20¹ ² ³ ⁵		MIP-3-Alpha¹
MIP3A² ³ ⁵		CC Chemokine LARC² ³
CKb4¹ ²		Exodus-1¹
MIP-3a¹ ²		Beta Chemokine Exodus-1²
ST38¹ ²		C-C Motif Chemokine 20²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20¹ ²		Beta-Chemokine Exodus-1³
Liver And Activation-Regulated Chemokine² ³

External Ids:	HGNC: 10619¹	Entrez Gene: 6364²	Ensembl: ENSG00000115009⁷	OMIM: 601960⁵	UniProtKB: P78556³

Export aliases for CCL20 gene to outside databases

Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed

forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli

ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL20 gene promoter:
HFH-3 Pax-5 Nkx2-2 NF-kappaB E47 C/EBPalpha FOXI1 Chx10 NF-kappaB1 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL20 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P228678: view genomic region (about GC identifiers)

Start:	228,678,558 bp from pter	End:	228,682,280 bp from pter
Size:	3,723 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)

Recommended Name: C-C motif chemokine 20 precursor

Size: 96 amino acids; 10762 Da

Subunit: Binds to and activate CCR6

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for CCL20:

1M8A (3D)

2HCI (3D)

2JYO (3D)

Secondary accessions: Q53S51 Q99664

Alternative splicing: 2 isoforms: P78556-1 P78556-2

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Post-translational modifications:

C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from

peripheral blood monocytes¹

View neXtProt modification sites for NX_P78556

CCL20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123518.1 NP_004582.1

ENSEMBL proteins:

ENSP00000386273 ENSP00000351671

Reactome Protein details: P78556
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL20 (CCL20/MIP-3 alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CCL20 OriGene Custom Protein Services for CCL20
	GenScript Purified and Recombinant Proteins for CCL20
	Novus Biologicals CCL20 Proteins Novus Biologicals CCL20 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL20
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL20 for ontologies About GeneDecksing

CCL20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL20 (CCL20/MIP-3 alpha)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CCL20
	GenScript Custom Superior Antibodies Services for CCL20
	Novus Biologicals CCL20 Antibodies
	Search for Antibodies for CCL20 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for CCL20

Assay Products for CCL20:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha) (see all)
	GenScript Custom Assay Services for CCL20
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL20 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P78556

ProtoNet protein and cluster: P78556

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed

forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli

ATCC 25922 and S.aureus ATCC 29213

Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA)

in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL20
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL20:
		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: CCL20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL20 (see all 7) OriGene shRNA RFP: CCL20 OriGene siRNA: CCL20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL20

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL20 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL20 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
		Sino Biological Human cDNA Clone for CCL20
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL20
		Search LifeMap BioReagents cell lines for CCL20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	--	--
GO:0005515	protein binding	--	--
GO:0008009	chemokine activity	IEA	--

CCL20 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CCL20:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCL20

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL20 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 GeneGo (Thomson Reuters) Pathways for CCL20

	Immune response TLR signaling pathways
	Bacterial infections in CF airways

1 BioSystems Pathway for CCL20

EBV LMP1 signaling

5/8 Reactome Pathways for CCL20 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

3 Kegg Pathways (Kegg details for CCL20):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Rheumatoid arthritis

CCL20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

133/158 Interacting proteins for CCL20 (P78556^{2, 3} ENSP00000351671⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 158) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF6	Q9Y4K3²^,³	MINT-6505246 I2D: score=1
RALBP1	Q15311²^,³, ENSP00000019317⁴	MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
CCR6	P51684³, ENSP00000339393⁴	I2D: score=3 STRING: ENSP00000339393
VCAN	P13611³, ENSP00000265077⁴	I2D: score=3 STRING: ENSP00000265077
CTSB	P07858³	I2D: score=1
CTSD	P07339³	I2D: score=1
ANXA1	ENSP00000257497⁴	STRING: ENSP00000257497
C3	ENSP00000245907⁴	STRING: ENSP00000245907
C5AR1	ENSP00000347197⁴	STRING: ENSP00000347197
CCL16	ENSP00000293275⁴	STRING: ENSP00000293275
CCL19	ENSP00000308815⁴	STRING: ENSP00000308815
CCL21	ENSP00000259607⁴	STRING: ENSP00000259607
CCL25	ENSP00000375086⁴	STRING: ENSP00000375086
CCL27	ENSP00000259631⁴	STRING: ENSP00000259631
CCL28	ENSP00000354416⁴	STRING: ENSP00000354416
CCL5	ENSP00000293272⁴	STRING: ENSP00000293272
CCR1	ENSP00000296140⁴	STRING: ENSP00000296140
CCR3	ENSP00000350003⁴	STRING: ENSP00000350003
CCR5	ENSP00000292303⁴	STRING: ENSP00000292303
CCR7	ENSP00000246657⁴	STRING: ENSP00000246657
CCR8	ENSP00000326432⁴	STRING: ENSP00000326432
CXCL1	ENSP00000379110⁴	STRING: ENSP00000379110
CXCL10	ENSP00000305651⁴	STRING: ENSP00000305651
CXCL11	ENSP00000306884⁴	STRING: ENSP00000306884
CXCL13	ENSP00000286758⁴	STRING: ENSP00000286758
CXCL16	ENSP00000293778⁴	STRING: ENSP00000293778
CXCL3	ENSP00000296026⁴	STRING: ENSP00000296026
CXCL5	ENSP00000296027⁴	STRING: ENSP00000296027
CXCL6	ENSP00000226317⁴	STRING: ENSP00000226317
CXCL9	ENSP00000354901⁴	STRING: ENSP00000354901
CXCR1	ENSP00000295683⁴	STRING: ENSP00000295683
CXCR2	ENSP00000319635⁴	STRING: ENSP00000319635
CXCR5	ENSP00000292174⁴	STRING: ENSP00000292174
CXCR6	ENSP00000304414⁴	STRING: ENSP00000304414
CXCR7	ENSP00000272928⁴	STRING: ENSP00000272928
FPR1	ENSP00000302707⁴	STRING: ENSP00000302707
FPR2	ENSP00000340191⁴	STRING: ENSP00000340191
HCAR2	ENSP00000375066⁴	STRING: ENSP00000375066
KNG1	ENSP00000265023⁴	STRING: ENSP00000265023
OPRK1	ENSP00000265572⁴	STRING: ENSP00000265572
OPRM1	ENSP00000394624⁴	STRING: ENSP00000394624
P2RY14	ENSP00000308361⁴	STRING: ENSP00000308361
POMC	ENSP00000264708⁴	STRING: ENSP00000264708
PPBP	ENSP00000296028⁴	STRING: ENSP00000296028
PTGDR2	ENSP00000332812⁴	STRING: ENSP00000332812
RGS1	ENSP00000356429⁴	STRING: ENSP00000356429
RGS14	ENSP00000386229⁴	STRING: ENSP00000386229
SST	ENSP00000287641⁴	STRING: ENSP00000287641
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361
ADCY6	ENSP00000311405⁴	STRING: ENSP00000311405
ADCY7	ENSP00000254235⁴	STRING: ENSP00000254235
ADCY8	ENSP00000286355⁴	STRING: ENSP00000286355
ADCY9	ENSP00000294016⁴	STRING: ENSP00000294016
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549
ADORA3	ENSP00000358730⁴	STRING: ENSP00000358730
ADRA2A	ENSP00000280155⁴	STRING: ENSP00000280155
ADRA2B	ENSP00000387281⁴	STRING: ENSP00000387281
ADRA2C	ENSP00000386069⁴	STRING: ENSP00000386069
AGTR2	ENSP00000360973⁴	STRING: ENSP00000360973
APLN	ENSP00000305464⁴	STRING: ENSP00000305464
APLNR	ENSP00000257254⁴	STRING: ENSP00000257254
APP	ENSP00000284981⁴	STRING: ENSP00000284981
BDKRB1	ENSP00000216629⁴	STRING: ENSP00000216629
BDKRB2	ENSP00000307713⁴	STRING: ENSP00000307713
C3AR1	ENSP00000302079⁴	STRING: ENSP00000302079
C5	ENSP00000223642⁴	STRING: ENSP00000223642
CASR	ENSP00000296154⁴	STRING: ENSP00000296154
CHRM2	ENSP00000319984⁴	STRING: ENSP00000319984
CHRM4	ENSP00000409378⁴	STRING: ENSP00000409378
DRD2	ENSP00000354859⁴	STRING: ENSP00000354859
DRD3	ENSP00000373169⁴	STRING: ENSP00000373169
DRD4	ENSP00000176183⁴	STRING: ENSP00000176183
FPR3	ENSP00000341821⁴	STRING: ENSP00000341821
GAL	ENSP00000265643⁴	STRING: ENSP00000265643
GALR1	ENSP00000299727⁴	STRING: ENSP00000299727
GALR2	ENSP00000329684⁴	STRING: ENSP00000329684
GALR3	ENSP00000249041⁴	STRING: ENSP00000249041
GNAI2	ENSP00000312999⁴	STRING: ENSP00000312999
GNG2	ENSP00000334448⁴	STRING: ENSP00000334448
GPER	ENSP00000297469⁴	STRING: ENSP00000297469
GPR17	ENSP00000272644⁴	STRING: ENSP00000272644
GPR18	ENSP00000343428⁴	STRING: ENSP00000343428
GPR55	ENSP00000375893⁴	STRING: ENSP00000375893
HEBP1	ENSP00000014930⁴	STRING: ENSP00000014930
HRH3	ENSP00000342560⁴	STRING: ENSP00000342560
HRH4	ENSP00000256906⁴	STRING: ENSP00000256906
HTR1A	ENSP00000316244⁴	STRING: ENSP00000316244
HTR1B	ENSP00000358963⁴	STRING: ENSP00000358963
HTR1D	ENSP00000313661⁴	STRING: ENSP00000313661
HTR1E	ENSP00000307766⁴	STRING: ENSP00000307766
HTR1F	ENSP00000322924⁴	STRING: ENSP00000322924
HTR5A	ENSP00000287907⁴	STRING: ENSP00000287907
LPAR1	ENSP00000351755⁴	STRING: ENSP00000351755
LPAR2	ENSP00000384665⁴	STRING: ENSP00000384665
LPAR3	ENSP00000359643⁴	STRING: ENSP00000359643
MCHR1	ENSP00000249016⁴	STRING: ENSP00000249016
MCHR2	ENSP00000281806⁴	STRING: ENSP00000281806
MTNR1A	ENSP00000302811⁴	STRING: ENSP00000302811
MTNR1B	ENSP00000257068⁴	STRING: ENSP00000257068
NMS	ENSP00000366061⁴	STRING: ENSP00000366061
NMU	ENSP00000264218⁴	STRING: ENSP00000264218
NMUR1	ENSP00000305877⁴	STRING: ENSP00000305877
NMUR2	ENSP00000255262⁴	STRING: ENSP00000255262
NPB	ENSP00000332766⁴	STRING: ENSP00000332766
NPBWR1	ENSP00000330284⁴	STRING: ENSP00000330284
NPBWR2	ENSP00000358783⁴	STRING: ENSP00000358783
NPW	ENSP00000330070⁴	STRING: ENSP00000330070
NPY	ENSP00000242152⁴	STRING: ENSP00000242152
NPY1R	ENSP00000354652⁴	STRING: ENSP00000354652
NPY2R	ENSP00000332591⁴	STRING: ENSP00000332591
NPY5R	ENSP00000339377⁴	STRING: ENSP00000339377
OPRD1	ENSP00000234961⁴	STRING: ENSP00000234961
OPRL1	ENSP00000336764⁴	STRING: ENSP00000336764
OXER1	ENSP00000367930⁴	STRING: ENSP00000367930
P2RY12	ENSP00000307259⁴	STRING: ENSP00000307259
P2RY13	ENSP00000320376⁴	STRING: ENSP00000320376
P2RY4	ENSP00000363643⁴	STRING: ENSP00000363643
PDYN	ENSP00000217305⁴	STRING: ENSP00000217305
PENK	ENSP00000324248⁴	STRING: ENSP00000324248
PMCH	ENSP00000332225⁴	STRING: ENSP00000332225
PNOC	ENSP00000301908⁴	STRING: ENSP00000301908
PPY	ENSP00000225992⁴	STRING: ENSP00000225992
PPYR1	ENSP00000363431⁴	STRING: ENSP00000363431
PTGER3	ENSP00000349003⁴	STRING: ENSP00000349003
PYY	ENSP00000353198⁴	STRING: ENSP00000353198
RGS10	ENSP00000358099⁴	STRING: ENSP00000358099
RGS18	ENSP00000356430⁴	STRING: ENSP00000356430
RGS19	ENSP00000333194⁴	STRING: ENSP00000333194
RGS20	ENSP00000297313⁴	STRING: ENSP00000297313
RGS4	ENSP00000397181⁴	STRING: ENSP00000397181

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	9038201
GO:0007267	cell-cell signaling	TAS	9038201

CCL20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL20
10/20 Novoseek chemical compound relationships for CCL20 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
larc	95.7	108	9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
mip-3alpha	86.4	9	15069060 (7), 11352563 (1), 17928889 (1)
tarc	76.2	12	9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
ccl3	76.1	11	18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
rantes	68.8	25	18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
ccl4	60	15	18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
flagellin	51.8	8	15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
il-12	43.4	1	15860229 (1)
poly(i-c)	33	1	16911361 (1)
imac	32	7	16034074 (4)

Search CenterWatch for drugs/clinical trials and news about CCL20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL20 gene (2 alternative transcripts):

NM_001130046.1 NM_004591.2

Unigene Cluster for CCL20:

Chemokine (C-C motif) ligand 20

Hs.75498 [show with all ESTs]

Unigene Representative Sequence: BC020698

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813

ENST00000473642

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		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

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Additional cDNA sequence:

BC020698.1 D86955.1 U64197.1 U77035.1

5 DOTS entries:

DT.211225 DT.95102901 DT.100777315 DT.91717429 DT.100777317

24/76 AceView cDNA sequences (see all 76):

AA297433 AA983599 D17012 BM833314 AW965098 AW168095 D17181 CD640247

BM955557 BM955559 BG534134 CD523297 CD521287 CD641783 AA514362 AI285199

AI718638 D86955 BM956129 BM955558 U77035 AU185348 NM_004591 AW084987

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b
SP1:					-
SP2:					-
SP3:

ECgene alternative splicing isoforms for CCL20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGTTTAG

About this image

CCL20 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCL20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL20

SOURCE GeneReport for Unigene cluster: Hs.75498

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and

fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL20 (see all 8):

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antigen Presenting Cells in human mouse rat

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL20 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccl20^{1 , 5}	chemokine (C-C motif) ligand 20^{1, 5}	72.98(n)¹ 64.21(a)¹		1 (42.69 cM)⁵ 20297¹ NM_016960.2¹ NP_058656.1¹ 83116766⁵
chicken (Gallus gallus)	Aves	CCL20¹	chemokine (C-C motif) ligand 20	61.65(n) 55.91(a)		395082 NM_204438.1 NP_989769.1
zebrafish (Danio rerio)	Actinopterygii	ccl20⁶ zgc:195209⁶	zgc:195209	32(a) 30(a)	many → 1 many → 1	24(26803332-26806214) 2(45241704-45243634)

ENSEMBL Gene Tree for CCL20 (if available)
TreeFam Gene Tree for CCL20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183824178^1,2		--	228676559(+)	`GTTGGC/TCAGGT`	2	--	us2k¹		0	--	--	--	--
rs78499763^1,2	C,F,	--	228676591(+)	`CGGCTC/TGCCGT`	2	--	us2k¹		1		EA	120
rs10179600^1,2	C,F,H,	--	228676594(+)	`CTCGCC/TGTAAC`	2	--	us2k¹		13		NS EA NA WA CSA	784
rs146001732^1,2		--	228676769(+)	`CACCTC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs189274596^1,2		--	228676770(+)	`ACCTCA/GGCCTC`	2	--	us2k¹		0	--	--	--	--
rs148680581^1,2		--	228676796(+)	`TACAGG/TCATGA`	2	--	us2k¹		0	--	--	--	--
rs115085538^1,2	F,	--	228676856(+)	`CTTTCT/CGTCTG`	2	--	us2k¹		1		WA	118
rs62190005^1,2	C,	--	228676922(+)	`CAGTCG/AGTTTA`	2	--	us2k¹		5		NA WA EA	362
rs192578932^1,2		--	228676974(+)	`CCTAGA/GGAACA`	2	--	us2k¹		0	--	--	--	--
rs185133799^1,2		--	228676976(+)	`TAGAGA/TACATT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCL20
1 CNV: 32395

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL20 for disorders           About GeneDecksing

OMIM gene information: 601960    OMIM disorders: --

20/71 diseases for CCL20 (see all 71):    About MalaCards

middle ear cholesteatoma inflammatory bowel disease hordeolum chronic obstructive pulmonary disease

smallpox intrauterine infections obstructive jaundice acute liver failure

cystic fibrosis allergic rhinitis peripheral t-cell lymphoma cholesteatoma

atopic dermatitis jaundice rheumatoid arthritis pulmonary disease

hepatitis c periodontal disease ulcerative colitis viral hepatitis

3 diseases from the University of Copenhagen DISEASES database for CCL20:

Psoriasis Hordeolum Inflammatory bowel disease

10/32 Novoseek disease relationships for CCL20 gene (see all 32) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	57.2	25	17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
necrosis	56.7	34	16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
inflammatory bowel diseases	49.3	11	12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
psoriasis	48.2	14	15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
tumors	38.9	63	19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
dermatitis atopic	35.6	2	11133838 (1), 17369706 (1)
rheumatoid arthritis	34.1	10	19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
colitis ulcerative	30.1	4	12427784 (2), 16306769 (1), 18340639 (1)
pathological processes	22.7	1	12356943 (1)
skin lesion	19.9	2	15315355 (1), 19659772 (1)

Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

Export disorders for CCL20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL20 gene, integrated from 9 sources (see all 348):
(articles sorted by number of sources associating them with CCL20)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)^{1, 2, 3, 9} Hieshima K.... Nomiyama H. (1997)
Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)^{1, 2, 3, 9} Nelson R.T.... McColl S.R. (2001)
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)^{1, 2, 9} Hoover D.M....Lubkowski J. (2002)
Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)^{1, 2, 9} Schutyser E.... Van Damme J. (2000)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939)^{1, 2} Rossi D.L.... Zlotnik A. (1997)
Cloning and characterization of Exodus, a novel beta-chemokine. (PubMed id 9129037)^{1, 2} Hromas R.A.... Klemsz M.J. (1997)
Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like syno vial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modi fying antirheumatic drugs. (PubMed id 19797510)^{1, 9} Kawashiri S.Y....Eguchi K. (2009)
Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. (PubMed id 18980993)^{1, 9} Chang K.P....Yu J.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6364	HGNC: 10619	AceView: CCL20	Ensembl:ENSG00000115009	euGenes: HUgn6364
ECgene: CCL20	Kegg: 6364	H-InvDB: CCL20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL20	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL20

Intellectual Property for CCL20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCL20 gene:
Search GeneIP for patents involving CCL20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CCL20 Gene

chemokine (C-C motif) ligand 20

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CCL20 Gene

chemokine (C-C motif) ligand 20

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