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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL20 Gene

protein-coding   GIFtS: 64
GCID: GC02P228678

Chemokine (C-C Motif) Ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 2...)
(Previous symbol: SCYA20)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 201 2     MIP-3-alpha2 3
SCYA201 2 3 5     CC Chemokine LARC2 3
LARC2 3 5     CKb42
MIP3A2 3 5     MIP-3a2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 201 2     ST382
Liver And Activation-Regulated Chemokine2 3     Beta Chemokine Exodus-12
Macrophage Inflammatory Protein 3 Alpha2 3     C-C Motif Chemokine 202
Small-Inducible Cytokine A202 3     Beta-Chemokine Exodus-13

External Ids:    HGNC: 106191   Entrez Gene: 63642   Ensembl: ENSG000001150097   OMIM: 6019605   UniProtKB: P785563   

Export aliases for CCL20 gene to outside databases

Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCL20 Gene: 
CCL20 (chemokine (C-C motif) ligand 20) is a protein-coding gene. Diseases associated with CCL20 include hordeolum, and smallpox, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
activity E.coli ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL20 gene promoter:
         HFH-3   Pax-5   Nkx2-2   NF-kappaB   E47   C/EBPalpha   FOXI1   Chx10   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL20 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P228678:  view genomic region     (about GC identifiers)

Start:
228,678,558 bp from pter      End:
228,682,280 bp from pter
Size:
3,723 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)
Recommended Name: C-C motif chemokine 20 precursor  
Size: 96 amino acids; 10762 Da
Subunit: Binds to and activate CCR6
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for CCL20:
1M8A (3D)        2HCI (3D)        2JYO (3D)    
Secondary accessions: Q53S51 Q99664
Alternative splicing: 2 isoforms:  P78556-1   P78556-2   

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Explore proteomics data for CCL20 at MOPED 

Post-translational modifications:

  • UniProtKB: C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion
    from peripheral blood monocytes
  • View neXtProt modification sites for NX_P78556

  • CCL20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL20 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123518.1  NP_004582.1  

    ENSEMBL proteins: 
     ENSP00000386273   ENSP00000351671  
    Reactome Protein details: P78556
    Human Recombinant Protein Products for CCL20: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL20 (CCL20/MIP-3 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL20
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCL20
    GenScript Purified and Recombinant Proteins for CCL20
    Novus Biologicals CCL20 Proteins
    Novus Biologicals CCL20 Lysates
    Sino Biological Recombinant Protein for CCL20
    Sino Biological Cell Lysate for CCL20 
    ProSpec Recombinant Protein for CCL20
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL20 for ontologies           About GeneDecksing



    CCL20 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL20 (CCL20/MIP-3 alpha)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL20
    GenScript Custom Superior Antibodies Services for CCL20
    Novus Biologicals CCL20 Antibodies
    Abcam antibodies for CCL20
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CCL20
    LSBio Antibodies in human, mouse, rat for CCL20 

    Assay Products for CCL20: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL20
    R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha)         (see all)
    GenScript Custom Assay Services for CCL20
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P78556

    ProtoNet protein and cluster: P78556

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL20_HUMAN, P78556
    Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
    proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
    mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
    processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
    activity E.coli ATCC 25922 and S.aureus ATCC 29213
    Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate
    (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005515protein binding IPI17703191
    GO:0008009chemokine activity IEA--
         
    CCL20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL20:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL20 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL20 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL20
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL20:
    hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidCCL20 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL20
    Sirion Biotech Customized adenovirus for overexpression of CCL20

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL20 (see all 9)
    OriGene ORF clones in mouse, rat for CCL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
    Sino Biological Human cDNA Clone for CCL20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20
    Sirion Biotech Customized lentivirus for stable overexpression of CCL20 
                         Customized lentivirus expression plasmids for stable overexpression of CCL20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL20
    Search LifeMap BioReagents cell lines for CCL20
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL20 About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL20
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL20 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL20
        Immune response TLR signaling pathways
    Bacterial infections in CF airways

    1 BioSystems Pathway for CCL20
        EBV LMP1 signaling


    5/8        Reactome Pathways for CCL20 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    4         Kegg Pathways  (Kegg details for CCL20):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway
    Rheumatoid arthritis


    CCL20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    133/158 Interacting proteins for CCL20 (P785562, 3 ENSP000003516714) via UniProtKB, MINT, STRING, and/or I2D (see all 158) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K32, 3MINT-6505246 I2D: score=1 
    RALBP1Q153112, 3, ENSP000000193174MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
    CCR6P516843, ENSP000003393934I2D: score=3 STRING: ENSP00000339393
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CTSBP078583I2D: score=1 
    CTSDP073393I2D: score=1 
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ANXA1ENSP000002574974STRING: ENSP00000257497
    C3ENSP000002459074STRING: ENSP00000245907
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR7ENSP000002466574STRING: ENSP00000246657
    CCR8ENSP000003264324STRING: ENSP00000326432
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    HCAR2ENSP000003750664STRING: ENSP00000375066
    KNG1ENSP000002650234STRING: ENSP00000265023
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRM1ENSP000003946244STRING: ENSP00000394624
    P2RY14ENSP000003083614STRING: ENSP00000308361
    POMCENSP000002647084STRING: ENSP00000264708
    PPBPENSP000002960284STRING: ENSP00000296028
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    RGS1ENSP000003564294STRING: ENSP00000356429
    RGS14ENSP000003862294STRING: ENSP00000386229
    SSTENSP000002876414STRING: ENSP00000287641
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    AGTR2ENSP000003609734STRING: ENSP00000360973
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5ENSP000002236424STRING: ENSP00000223642
    CASRENSP000002961544STRING: ENSP00000296154
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    DRD4ENSP000001761834STRING: ENSP00000176183
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH3ENSP000003425604STRING: ENSP00000342560
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1AENSP000003028114STRING: ENSP00000302811
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPYENSP000002421524STRING: ENSP00000242152
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PDYNENSP000002173054STRING: ENSP00000217305
    PENKENSP000003242484STRING: ENSP00000324248
    PMCHENSP000003322254STRING: ENSP00000332225
    PNOCENSP000003019084STRING: ENSP00000301908
    PPYENSP000002259924STRING: ENSP00000225992
    PTGER3ENSP000003490034STRING: ENSP00000349003
    PYYENSP000003531984STRING: ENSP00000353198
    RGS10ENSP000003580994STRING: ENSP00000358099
    RGS18ENSP000003564304STRING: ENSP00000356430
    RGS19ENSP000003331944STRING: ENSP00000333194
    RGS20ENSP000002973134STRING: ENSP00000297313
    RGS4ENSP000003971814STRING: ENSP00000397181
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9038201
    GO:0007267cell-cell signaling TAS9038201

    CCL20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL20

    10/20 Novoseek inferred chemical compound relationships for CCL20 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    larc 95.7 108 9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
    mip-3alpha 86.4 9 15069060 (7), 11352563 (1), 17928889 (1)
    tarc 76.2 12 9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
    ccl3 76.1 11 18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
    rantes 68.8 25 18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
    ccl4 60 15 18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
    flagellin 51.8 8 15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
    il-12 43.4 1 15860229 (1)
    poly(i-c) 33 1 16911361 (1)
    imac 32 7 16034074 (4)

    Search CenterWatch for drugs/clinical trials and news about CCL20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL20 gene (2 alternative transcripts): 
    NM_001130046.1  NM_004591.2  

    Unigene Cluster for CCL20:

    Chemokine (C-C motif) ligand 20
    Hs.75498  [show with all ESTs]
    Unigene Representative Sequence: BC020698
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813
    ENST00000473642
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    BC020698.1 D86955.1 U64197.1 U77035.1 

    5 DOTS entries:

    DT.211225  DT.95102901  DT.100777315  DT.91717429  DT.100777317 

    24/76 AceView cDNA sequences (see all 76):

    AA983599 BM833314 AW168095 AA297433 D17181 D17012 AW965098 BG950969 
    BE042488 CD641783 CD521287 BM955561 BG534134 NM_004591 AA527293 CD523297 
    U77035 BE439997 BM956129 AW072796 D86955 BM956130 AU185348 CD640247 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:              -                     
    SP2:              -                     
    SP3:                                    


    ECgene alternative splicing isoforms for CCL20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL20 expression in normal human tissues (normalized intensities)      CCL20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTTTAG
    CCL20 Expression
    About this image


    CCL20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
             Human Annulus Fibrosus Cells (HAFC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
             Human Calvarial Osteoblasts (HCO)   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Epithelium (Endocrine System)    fully expand to see all 3 entries
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Lymphatic Fibroblasts (HLF)   

    See CCL20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL20

    SOURCE GeneReport for Unigene cluster: Hs.75498

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and
    fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL20 (see all 8): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL20 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl201 , 5 chemokine (C-C motif) ligand 201, 5 72.98(n)1
    64.21(a)1
      1 (42.69 cM)5
    202971  NM_016960.21  NP_058656.11 
     831167665 
    chicken
    (Gallus gallus)
    Aves CCL201 chemokine (C-C motif) ligand 20 61.65(n)
    55.91(a)
      395082  NM_204438.1  NP_989769.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCL206
    chemokine (C-C motif) ligand 20
    44(a)
    1 ↔ 1
    3(23292927-23296252)
    zebrafish
    (Danio rerio)
    Actinopterygii ccl206
    CCL20 (2 of 2)6
    chemokine (C-C motif) ligand 20
    31(a)
    30(a)
    many → 1
    many → 1
    24(26803332-26806214)
    2(45241704-45243634)


    ENSEMBL Gene Tree for CCL20 (if available)
    TreeFam Gene Tree for CCL20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL20 gene
    18 SIMAP similar genes for CCL20 using alignment to 1 protein entry:     CCL20_HUMAN:
    CCL16    CCL26    CCL2    CCL21    CCL11    CCL18
    CCL23    CCL3    CCL4    CCL3L1    CCL3L3    CCL5
    CCL7    MCP-3    CCL8    CCL24    IL8    LOC728835

    CCL20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 SNPs in CCL20 are shown (see all 168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838241781,2
    --228676559(+) GTTGGC/TCAGGT 2 -- us2k10--------
    rs784997631,2
    C,F--228676591(+) CGGCTC/TGCCGT 2 -- us2k11Minor allele frequency- T:0.08EA 120
    rs101796001,2
    C,F,H--228676594(+) ctcgcC/Tgtaac 2 -- us2k113Minor allele frequency- T:0.35NS EA NA WA CSA 784
    rs1460017321,2
    --228676769(+) CACCTC/TGGCCT 2 -- us2k10--------
    rs1892745961,2
    C--228676770(+) ACCTCA/GGCCTC 2 -- us2k10--------
    rs1486805811,2
    --228676796(+) TACAGG/TCATGA 2 -- us2k10--------
    rs1150855381,2
    C,F--228676856(+) CTTTCT/CGTCTG 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs621900051,2
    C--228676922(+) CAGTCG/AGTTTA 2 -- us2k15Minor allele frequency- A:0.24NA WA EA 362
    rs1925789321,2
    --228676974(+) CCTAGA/GGAACA 2 -- us2k10--------
    rs1851337991,2
    --228676976(+) TAGAGA/TACATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL20:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv10221CNV Loss18304495
    nsv834562CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601960    OMIM disorders: --

    20/70 diseases for CCL20 (see all 70):    About MalaCards
    hordeolum    smallpox    stromal keratitis    pustulosis palmaris et plantaris
    middle ear cholesteatoma    periodontal disease    obstructive jaundice    acute liver failure
    intrauterine infections    peripheral t-cell lymphoma    cholesteatoma    jaundice
    endometrial adenocarcinoma    vaginitis    keratitis    papillary carcinoma
    inflammatory bowel disease    viral hepatitis    periodontitis    hiv type 1

    2 diseases from the University of Copenhagen DISEASES database for CCL20:
    Psoriasis     Inflammatory bowel disease

    CCL20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/32 Novoseek inferred disease relationships for CCL20 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 57.2 25 17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
    necrosis 56.7 34 16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
    inflammatory bowel diseases 49.3 11 12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
    psoriasis 48.2 14 15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
    tumors 38.9 63 19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
    dermatitis atopic 35.6 2 11133838 (1), 17369706 (1)
    rheumatoid arthritis 34.1 10 19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
    colitis ulcerative 30.1 4 12427784 (2), 16306769 (1), 18340639 (1)
    pathological processes 22.7 1 12356943 (1)
    skin lesion 19.9 2 15315355 (1), 19659772 (1)

    Genetic Association Database (GAD): CCL20
    Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

    Export disorders for CCL20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL20 gene, integrated from 9 sources (see all 357):
    (articles sorted by number of sources associating them with CCL20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)1, 2, 3, 9 Hieshima K.... Nomiyama H. (1997)
    2. Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)1, 2, 3, 9 Nelson R.T.... McColl S.R. (2001)
    3. The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)1, 2, 9 Hoover D.M....Lubkowski J. (2002)
    4. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)1, 2, 9 Schutyser E.... Van Damme J. (2000)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)1, 4 Levy D....Mitchell G.F. (2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6364 HGNC: 10619 AceView: CCL20 Ensembl:ENSG00000115009 euGenes: HUgn6364
    ECgene: CCL20 Kegg: 6364 H-InvDB: CCL20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL20 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL20

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL20 gene:
    Search GeneIP for patents involving CCL20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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