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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL20 Gene

protein-coding GIFtS: 64
GCID: GC02P228678

Chemokine (C-C Motif) Ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 2...)
(Previous symbol: SCYA20)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 20¹ ²		MIP-3-alpha² ³
SCYA20¹ ² ³ ⁵		CC Chemokine LARC² ³
LARC² ³ ⁵		CKb4²
MIP3A² ³ ⁵		MIP-3a²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20¹ ²		ST38²
Liver And Activation-Regulated Chemokine² ³		Beta Chemokine Exodus-1²
Macrophage Inflammatory Protein 3 Alpha² ³		C-C Motif Chemokine 20²
Small-Inducible Cytokine A20² ³		Beta-Chemokine Exodus-1³

External Ids:	HGNC: 10619¹	Entrez Gene: 6364²	Ensembl: ENSG00000115009⁷	OMIM: 601960⁵	UniProtKB: P78556³

Export aliases for CCL20 gene to outside databases

Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCL20 Gene:

CCL20 (chemokine (C-C motif) ligand 20) is a protein-coding gene. Diseases associated with CCL20 include hordeolum, and smallpox, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal

processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial

activity E.coli ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.2 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL20 gene promoter:
HFH-3 Pax-5 Nkx2-2 NF-kappaB E47 C/EBPalpha FOXI1 Chx10 NF-kappaB1 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL20 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P228678: view genomic region (about GC identifiers)

Start:	228,678,558 bp from pter	End:	228,682,280 bp from pter
Size:	3,723 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)

Recommended Name: C-C motif chemokine 20 precursor

Size: 96 amino acids; 10762 Da

Subunit: Binds to and activate CCR6

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for CCL20:

1M8A (3D)

2HCI (3D)

2JYO (3D)

Secondary accessions: Q53S51 Q99664

Alternative splicing: 2 isoforms: P78556-1 P78556-2

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Explore proteomics data for CCL20 at MOPED

Post-translational modifications:

UniProtKB: C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion

from peripheral blood monocytes

View neXtProt modification sites for NX_P78556

CCL20 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123518.1 NP_004582.1

ENSEMBL proteins:

ENSP00000386273 ENSP00000351671

Reactome Protein details: P78556
Human Recombinant Protein Products for CCL20:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL20 (CCL20/MIP-3 alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Purified and Recombinant Proteins for CCL20
	Novus Biologicals CCL20 Proteins Novus Biologicals CCL20 Lysates
	Sino Biological Recombinant Protein for CCL20 Sino Biological Cell Lysate for CCL20
	ProSpec Recombinant Protein for CCL20
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL20 for ontologies About GeneDecksing

CCL20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals CCL20 Antibodies
	Abcam antibodies for CCL20
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	ThermoFisher Antibodies for CCL20
	LSBio Antibodies in human, mouse, rat for CCL20

Assay Products for CCL20:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCL20
	R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha) (see all)
	GenScript Custom Assay Services for CCL20
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ENDOLIG: Endogenous ligands

CCL: Chemokine ligands

2 InterPro protein domains:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P78556

ProtoNet protein and cluster: P78556

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Similarity: Belongs to the intercrine beta (chemokine CC) family

CCL20 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal

processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial

activity E.coli ATCC 25922 and S.aureus ATCC 29213

Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate

(PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	--	--
GO:0005515	protein binding	IPI	17703191
GO:0008009	chemokine activity	IEA	--

CCL20 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CCL20:

Increased cell number in G2M,

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL20

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL20

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL20

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL20

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL20
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL20:
		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: CCL20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CCL20
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CCL20
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CCL20 (see all 9) OriGene ORF clones in mouse, rat for CCL20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
		Sino Biological Human cDNA Clone for CCL20
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		Sirion Biotech Customized lentivirus for stable overexpression of CCL20 Customized lentivirus expression plasmids for stable overexpression of CCL20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL20
		Search LifeMap BioReagents cell lines for CCL20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CCL20 About (see all 15)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Mediated Glucocorticoid Regulation	0.94	NFAT Signaling and Lymphocyte Interactions	0.57
MIF Regulation of Innate Immune Cells	0.94	PGC1Alpha Pathway	0.51
PEDF Induced Signaling	0.73	STAT3 Pathway	0.47
all-trans-Retinoic Acid Signaling in Brain	0.71	Endothelin-1 Signaling Pathway	0.46

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

0.94

Immune response TLR signaling pathways

0.94

Chemokine Signaling

Chemokine Signaling

0.33

Chemokine signaling pathway

0.33

TGF-Beta Pathway

TGF-Beta Pathway	0.60	JNK Pathway	0.51
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.40

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.46

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for CCL20

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL20 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 GeneGo (Thomson Reuters) Pathways for CCL20

	Immune response TLR signaling pathways
	Bacterial infections in CF airways

1 BioSystems Pathway for CCL20

EBV LMP1 signaling

5/8 Reactome Pathways for CCL20 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

4 Kegg Pathways (Kegg details for CCL20):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	TNF signaling pathway
	Rheumatoid arthritis

CCL20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/158 Interacting proteins for CCL20 (P78556^{2, 3} ENSP00000351671⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 158)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF6	Q9Y4K3²^,³	MINT-6505246 I2D: score=1
RALBP1	Q15311²^,³, ENSP00000019317⁴	MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
CCR6	P51684³, ENSP00000339393⁴	I2D: score=3 STRING: ENSP00000339393
VCAN	P13611³, ENSP00000265077⁴	I2D: score=3 STRING: ENSP00000265077
CTSB	P07858³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	9038201
GO:0007267	cell-cell signaling	TAS	9038201

CCL20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL20

10/20 Novoseek inferred chemical compound relationships for CCL20 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
larc	95.7	108	9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
mip-3alpha	86.4	9	15069060 (7), 11352563 (1), 17928889 (1)
tarc	76.2	12	9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
ccl3	76.1	11	18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
rantes	68.8	25	18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
ccl4	60	15	18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
flagellin	51.8	8	15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
il-12	43.4	1	15860229 (1)
poly(i-c)	33	1	16911361 (1)
imac	32	7	16034074 (4)

Search CenterWatch for drugs/clinical trials and news about CCL20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL20 gene (2 alternative transcripts):

NM_001130046.1 NM_004591.2

Unigene Cluster for CCL20:

Chemokine (C-C motif) ligand 20

Hs.75498 [show with all ESTs]

Unigene Representative Sequence: BC020698

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813

ENST00000473642

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL20
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL20:
		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: CCL20 3' UTR sequence

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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
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		Sirion Biotech Customized lentivirus for stable overexpression of CCL20 Customized lentivirus expression plasmids for stable overexpression of CCL20

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL20
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL20

Additional mRNA sequence:

BC020698.1 D86955.1 U64197.1 U77035.1

5 DOTS entries:

DT.211225 DT.95102901 DT.100777315 DT.91717429 DT.100777317

24/76 AceView cDNA sequences (see all 76):

AA983599 BM833314 AW168095 AA297433 D17181 D17012 AW965098 BG950969

BE042488 CD641783 CD521287 BM955561 BG534134 NM_004591 AA527293 CD523297

U77035 BE439997 BM956129 AW072796 D86955 BM956130 AU185348 CD640247

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b
SP1:					-
SP2:					-
SP3:

ECgene alternative splicing isoforms for CCL20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL20 expression in normal human tissues (normalized intensities) CCL20 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGGGTTTAG

About this image

CCL20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/18 selected tissues (see all 18) fully expand


Cartilage (Muscoskeletal System) fully expand to see all 3 entries
TGFbeta3+BMP7-induced chondrocytes
Human Annulus Fibrosus Cells (HAFC)

Bone (Muscoskeletal System) fully expand to see all 3 entries
TGFbeta3+BMP7-induced chondrocytes
Human Calvarial Osteoblasts (HCO)

Lung (Respiratory System) fully expand to see all 3 entries
Human Pulmonary Artery Smooth Muscle Cells (HPASMC)

Epithelium (Endocrine System) fully expand to see all 3 entries
Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)

Fibroblast (Uncategorized) fully expand to see all 2 entries
Human Lymphatic Fibroblasts (HLF)

See CCL20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL20

SOURCE GeneReport for Unigene cluster: Hs.75498

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and

fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL20 (see all 8):

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antigen Presenting Cells in human mouse rat

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CCL20 OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL20 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccl20^{1 , 5}	chemokine (C-C motif) ligand 20^{1, 5}	72.98(n)¹ 64.21(a)¹		1 (42.69 cM)⁵ 20297¹ NM_016960.2¹ NP_058656.1¹ 83116766⁵
chicken (Gallus gallus)	Aves	CCL20¹	chemokine (C-C motif) ligand 20	61.65(n) 55.91(a)		395082 NM_204438.1 NP_989769.1
lizard (Anolis carolinensis)	Reptilia	CCL20⁶	chemokine (C-C motif) ligand 20	44(a)	1 ↔ 1	3(23292927-23296252)
zebrafish (Danio rerio)	Actinopterygii	ccl20⁶ CCL20 (2 of 2)⁶	chemokine (C-C motif) ligand 20	31(a) 30(a)	many → 1 many → 1	24(26803332-26806214) 2(45241704-45243634)

ENSEMBL Gene Tree for CCL20 (if available)
TreeFam Gene Tree for CCL20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL20 gene

18 SIMAP similar genes for CCL20 using alignment to 1 protein entry: CCL20_HUMAN:

CCL16 CCL26 CCL2 CCL21 CCL11 CCL18

CCL23 CCL3 CCL4 CCL3L1 CCL3L3 CCL5

CCL7 MCP-3 CCL8 CCL24 IL8 LOC728835

CCL20 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183824178^1,2		--	228676559(+)	`GTTGGC/TCAGGT`	2	--	us2k¹		0	--	--	--	--
rs78499763^1,2	C,F	--	228676591(+)	`CGGCTC/TGCCGT`	2	--	us2k¹		1		EA	120
rs10179600^1,2	C,F,H	--	228676594(+)	`ctcgcC/Tgtaac`	2	--	us2k¹		13		NS EA NA WA CSA	784
rs146001732^1,2		--	228676769(+)	`CACCTC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs189274596^1,2	C	--	228676770(+)	`ACCTCA/GGCCTC`	2	--	us2k¹		0	--	--	--	--
rs148680581^1,2		--	228676796(+)	`TACAGG/TCATGA`	2	--	us2k¹		0	--	--	--	--
rs115085538^1,2	C,F	--	228676856(+)	`CTTTCT/CGTCTG`	2	--	us2k¹		1		WA	118
rs62190005^1,2	C	--	228676922(+)	`CAGTCG/AGTTTA`	2	--	us2k¹		5		NA WA EA	362
rs192578932^1,2		--	228676974(+)	`CCTAGA/GGAACA`	2	--	us2k¹		0	--	--	--	--
rs185133799^1,2		--	228676976(+)	`TAGAGA/TACATT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CCL20: About this table

Variant ID	Type	Subtype	PubMed ID
nsv10221	CNV	Loss	18304495
nsv834562	CNV	Gain	17160897

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601960 OMIM disorders: --

20/70 diseases for CCL20 (see all 70): About MalaCards

hordeolum smallpox stromal keratitis pustulosis palmaris et plantaris

middle ear cholesteatoma periodontal disease obstructive jaundice acute liver failure

intrauterine infections peripheral t-cell lymphoma cholesteatoma jaundice

endometrial adenocarcinoma vaginitis keratitis papillary carcinoma

inflammatory bowel disease viral hepatitis periodontitis hiv type 1

2 diseases from the University of Copenhagen DISEASES database for CCL20:

Psoriasis Inflammatory bowel disease

CCL20 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/32 Novoseek inferred disease relationships for CCL20 gene (see all 32) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	57.2	25	17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
necrosis	56.7	34	16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
inflammatory bowel diseases	49.3	11	12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
psoriasis	48.2	14	15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
tumors	38.9	63	19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
dermatitis atopic	35.6	2	11133838 (1), 17369706 (1)
rheumatoid arthritis	34.1	10	19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
colitis ulcerative	30.1	4	12427784 (2), 16306769 (1), 18340639 (1)
pathological processes	22.7	1	12356943 (1)
skin lesion	19.9	2	15315355 (1), 19659772 (1)

Genetic Association Database (GAD): CCL20
Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

Export disorders for CCL20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCL20 gene, integrated from 9 sources (see all 357):
(articles sorted by number of sources associating them with CCL20)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)^{1, 2, 3, 9} Hieshima K.... Nomiyama H. (1997)
Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)^{1, 2, 3, 9} Nelson R.T.... McColl S.R. (2001)
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)^{1, 2, 9} Hoover D.M....Lubkowski J. (2002)
Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)^{1, 2, 9} Schutyser E.... Van Damme J. (2000)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (2010)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)^{1, 4} Levy D....Mitchell G.F. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6364	HGNC: 10619	AceView: CCL20	Ensembl:ENSG00000115009	euGenes: HUgn6364
ECgene: CCL20	Kegg: 6364	H-InvDB: CCL20

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCL20	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL20

Intellectual Property for CCL20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCL20 gene:
Search GeneIP for patents involving CCL20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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Chemokine (C-C Motif) Ligand 20

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