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CCL20 Gene

protein-coding GIFtS: 65
GCID: GC02P228678

Chemokine (C-C Motif) Ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 2...)
(Previous symbol: SCYA20)

See CCL20-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 20¹ ²		MIP-3-alpha² ³
SCYA20¹ ² ³ ⁵		CC Chemokine LARC² ³
LARC² ³ ⁵		CKb4²
MIP3A² ³ ⁵		MIP-3a²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20¹ ²		ST38²
Liver And Activation-Regulated Chemokine² ³		Beta Chemokine Exodus-1²
Macrophage Inflammatory Protein 3 Alpha² ³		C-C Motif Chemokine 20²
Small-Inducible Cytokine A20² ³		Beta-Chemokine Exodus-1³

External Ids:	HGNC: 10619¹	Entrez Gene: 6364²	Ensembl: ENSG00000115009⁷	OMIM: 601960⁵	UniProtKB: P78556³

ORGUL members:

Export aliases for CCL20 gene to outside databases

Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCL20 Gene:

CCL20 (chemokine (C-C motif) ligand 20) is a protein-coding gene. Diseases associated with CCL20 include smallpox, and pancreatic cancer. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal

processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial

activity E.coli ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NC_018913.2 NT_005403.18

Regulatory elements:

Regulatory transcription factor binding sites in the CCL20 gene promoter:
HFH-3 Pax-5 Nkx2-2 NF-kappaB E47 C/EBPalpha FOXI1 Chx10 NF-kappaB1 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL20 promoter sequence

Search Chromatin IP Primers for CCL20

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P228678: view genomic region (about GC identifiers)

Start:	228,678,558 bp from pter	End:	228,682,280 bp from pter
Size:	3,723 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)

Recommended Name: C-C motif chemokine 20 precursor

Size: 96 amino acids; 10762 Da

Subunit: Binds to and activate CCR6

3 PDB 3D structures from and Proteopedia for CCL20:

1M8A (3D)

2HCI (3D)

2JYO (3D)

Secondary accessions: Q53S51 Q99664

Alternative splicing: 2 isoforms: P78556-1 P78556-2

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Explore proteomics data for CCL20 at MOPED

Post-translational modifications:

C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion

from peripheral blood monocytes¹

Modification sites at neXtProt

See CCL20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001123518.1 NP_004582.1

ENSEMBL proteins:

ENSP00000386273 ENSP00000351671

Reactome Protein details: P78556

CCL20 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL20 (CCL20/MIP-3 alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CCL20 OriGene Custom MassSpec OriGene Custom Protein Services for CCL20
	GenScript Purified and Recombinant Proteins for CCL20
	Novus Biologicals CCL20 Proteins Novus Biologicals CCL20 Lysates
	Sino Biological Recombinant Protein for CCL20 Sino Biological Cell Lysate for CCL20
	ProSpec Recombinant Protein for CCL20
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CCL20
	antibodies-online proteins for CCL20 (64 products)
	antibodies-online peptides for CCL20

CCL20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL20 (CCL20/MIP-3 alpha)
	OriGene Antibodies for CCL20 OriGene Custom Antibody Services for CCL20
	Novus Biologicals CCL20 Antibodies
	Abcam antibodies for CCL20
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CCL20
	antibodies-online antibodies for CCL20 (105 products)

CCL20 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCL20
	R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha) (see all)
	GenScript Custom Assay Services for CCL20
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CCL20
	antibodies-online kits for CCL20 (50 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

CCL: Chemokine ligands

2 InterPro protein domains:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P78556

ProtoNet protein and cluster: P78556

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Similarity: Belongs to the intercrine beta (chemokine CC) family

Find genes that share domains with CCL20 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CCL20_HUMAN, P78556

Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits

proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the

mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal

processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial

activity E.coli ATCC 25922 and S.aureus ATCC 29213

Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate

(PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	--	--
GO:0005515	protein binding	IPI	17703191
GO:0008009	chemokine activity	IEA	--

Find genes that share ontologies with CCL20 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for CCL20:

Increased cell number in G2M,

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CCL20

miRNA Products:		miRTarBase miRNAs that target CCL20: hsa-mir-335-5p (MIRT017837), hsa-mir-21-5p (MIRT006199)

		Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate CCL20:
		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: CCL20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCL20
		Predesigned siRNA for gene silencing in human, mouse, rat CCL20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL20

Clone Products:		OriGene clones in human, mouse for CCL20 (see all 11) OriGene ORF clones in mouse, rat for CCL20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
		Sino Biological Human cDNA Clone for CCL20
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL20
		Browse ESI BIO Cell Lines and PureStem Progenitors for CCL20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CCL20_HUMAN, P78556: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
nucleus	2

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

Find genes that share ontologies with CCL20 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCL20 About (see all 14)

See pathways by source

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SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Regulation of Innate Immune Cells	0.94	NFAT Signaling and Lymphocyte Interactions	0.57
MIF Mediated Glucocorticoid Regulation	0.94	PGC1Alpha Pathway	0.51
PEDF Induced Signaling	0.73	STAT3 Pathway	0.47
all-trans-Retinoic Acid Signaling in Brain	0.71	Endothelin-1 Signaling Pathway	0.46

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Chemokine receptors bind chemokines

0.81

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

0.81

Chemokine Signaling

Chemokine Signaling

0.33

Chemokine signaling pathway

0.33

TGF-Beta Pathway

TGF-Beta Pathway	0.60	JNK Pathway	0.51
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.40

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.44

Find genes that share SuperPaths with CCL20 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCL20

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL20 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 GeneGo (Thomson Reuters) Pathways for CCL20

	Immune response TLR signaling pathways
	Bacterial infections in CF airways

1 BioSystems Pathway for CCL20

EBV LMP1 signaling

2 Reactome Pathways for CCL20

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

4 Kegg Pathways (Kegg details for CCL20):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	TNF signaling pathway
	Rheumatoid arthritis

Pathway & Disease-focused RT² Profiler PCR Arrays including CCL20 (see all 8):

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antigen Presenting Cells in human mouse rat

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Interactions:

GeneGlobe Interaction Network for CCL20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCL20 (P78556^{1, 2, 3} ENSP00000351671⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 158)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF6	Q9Y4K3²^,³	MINT-6505246 I2D: score=1
RALBP1	Q15311¹^,²^,³, ENSP00000019317⁴	EBI-3913209,EBI-749285 MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
CCR6	P51684³, ENSP00000339393⁴	I2D: score=3 STRING: ENSP00000339393
VCAN	P13611³, ENSP00000265077⁴	I2D: score=3 STRING: ENSP00000265077
CTSB	P07858³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	10438902
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	9038201
GO:0007267	cell-cell signaling	TAS	9038201

Find genes that share ontologies with CCL20 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CCL20

Selected Novoseek inferred chemical compound relationships for CCL20 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
larc	95.7	108	9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
mip-3alpha	86.4	9	15069060 (7), 11352563 (1), 17928889 (1)
tarc	76.2	12	9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
ccl3	76.1	11	18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
rantes	68.8	25	18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
ccl4	60	15	18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
flagellin	51.8	8	15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
il-12	43.4	1	15860229 (1)
poly(i-c)	33	1	16911361 (1)
imac	32	7	16034074 (4)

Find genes that share compounds with CCL20 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCL20 gene (2 alternative transcripts):

NM_001130046.1 NM_004591.2

Unigene Cluster for CCL20:

Chemokine (C-C motif) ligand 20

Hs.75498 [show with all ESTs]

Unigene Representative Sequence: BC020698

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813

ENST00000473642

miRNA Products:		Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate CCL20:
		hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272

		SwitchGear 3'UTR luciferase reporter plasmid: CCL20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCL20
		Predesigned siRNA for gene silencing in human, mouse, rat CCL20

Clone Products:		OriGene clones in human, mouse for CCL20 (see all 11) OriGene ORF clones in mouse, rat for CCL20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see first 1): CCL20 (NM_004591 NM_001130046)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20

Primer Products:		OriGene qPCR primer pairs and template standards for CCL20 OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CCL20
		QuantiTect SYBR Green Assays in human, mouse, rat CCL20
		Search QuantiFast Probe-based Assays in human, mouse, rat CCL20

Additional mRNA sequence:

BC020698.1 D86955.1 U64197.1 U77035.1

5 DOTS entries:

DT.211225 DT.95102901 DT.100777315 DT.91717429 DT.100777317

Selected AceView cDNA sequences (see all 76):

BM833314 D17012 AA983599 D17181 AW965098 AA297433 AW168095 CD365673

CD641783 CD523297 AW072796 BM956130 AA527293 U77035 AW014484 BG563672

AU185348 AI285199 BE439997 D86955 BM955557 BG950969 AW084987 BC020698

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b
SP1:					-
SP2:					-
SP3:

ECgene alternative splicing isoforms for CCL20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGGGTTTAG

About this image

CCL20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Lung (Respiratory System)
Alveolar type II cells

Bone (Muscoskeletal System)
TGFbeta3+BMP7-induced chondrocytes

Cartilage (Muscoskeletal System)
TGFbeta3+BMP7-induced chondrocytes

Colon (Gastrointestinal Tract)

Tonsil (Hematopoietic System)

CCL20 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CCL20 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.75498

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556

Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and

fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

Pathway & Disease-focused RT² Profiler PCR Arrays including CCL20 (see all 8):

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antigen Presenting Cells in human mouse rat

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CCL20 OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CCL20
		QuantiTect SYBR Green Assays in human, mouse, rat CCL20
		Search QuantiFast Probe-based Assays in human, mouse, rat CCL20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCL20 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccl20^{1 , 5}	chemokine (C-C motif) ligand 20^{1, 5}	72.7(n)¹ 63.83(a)¹		1 (42.69 cM)⁵ 20297¹ NM_016960.2¹ NP_058656.1¹ 83116766⁵
chicken (Gallus gallus)	Aves	CCL20¹	chemokine (C-C motif) ligand 20	61.96(n) 56.52(a)		395082 NM_204438.2 NP_989769.1
lizard (Anolis carolinensis)	Reptilia	CCL20⁶	chemokine (C-C motif) ligand 20	47(a)	1 ↔ 1	3(23292927-23296252)

ENSEMBL Gene Tree for CCL20 (if available)
TreeFam Gene Tree for CCL20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCL20 gene

18 SIMAP similar genes for CCL20 using alignment to 1 protein entry: CCL20_HUMAN:

CCL16 CCL26 CCL2 CCL21 CCL11 CCL18

CCL23 CCL3 CCL4 CCL3L1 CCL3L3 CCL5

CCL7 MCP-3 CCL8 CCL24 IL8 LOC728835

Find genes that share paralogs with CCL20 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183824178^1,2		--	228676559(+)	`GTTGGC/TCAGGT`	2	--	us2k¹		0	--	--	--	--
rs78499763^1,2	C,F	--	228676591(+)	`CGGCTC/TGCCGT`	2	--	us2k¹		1		EA	120
rs10179600^1,2	C,F,H	--	228676594(+)	`ctcgcC/Tgtaac`	2	--	us2k¹		13		NS EA NA WA CSA	784
rs146001732^1,2		--	228676769(+)	`CACCTC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs189274596^1,2	C	--	228676770(+)	`ACCTCA/GGCCTC`	2	--	us2k¹		0	--	--	--	--
rs148680581^1,2		--	228676796(+)	`TACAGG/TCATGA`	2	--	us2k¹		0	--	--	--	--
rs115085538^1,2	C,F	--	228676856(+)	`CTTTCT/CGTCTG`	2	--	us2k¹		1		WA	118
rs62190005^1,2	C	--	228676922(+)	`CAGTCG/AGTTTA`	2	--	us2k¹		5		NA WA EA	362
rs192578932^1,2		--	228676974(+)	`CCTAGA/GGAACA`	2	--	us2k¹		0	--	--	--	--
rs185133799^1,2		--	228676976(+)	`TAGAGA/TACATT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CCL20: About this table

Variant ID	Type	Subtype	PubMed ID
nsv10221	CNV	Loss	18304495
nsv834562	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CCL20

DNA2.0 Custom Variant and Variant Library Synthesis for CCL20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601960 OMIM disorders: --

4 diseases for CCL20:
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smallpox pancreatic cancer stromal keratitis pustulosis palmaris et plantaris

2 inferred disease relationships from the University of Copenhagen DISEASES database for CCL20:

Psoriasis Inflammatory bowel disease

Find genes that share disorders with CCL20 About GenesLikeMe

Selected Novoseek inferred disease relationships for CCL20 gene (see all 32) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	57.2	25	17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
necrosis	56.7	34	16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
inflammatory bowel diseases	49.3	11	12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
psoriasis	48.2	14	15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
tumors	38.9	63	19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
dermatitis atopic	35.6	2	11133838 (1), 17369706 (1)
rheumatoid arthritis	34.1	10	19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
colitis ulcerative	30.1	4	12427784 (2), 16306769 (1), 18340639 (1)
pathological processes	22.7	1	12356943 (1)
skin lesion	19.9	2	15315355 (1), 19659772 (1)

Genetic Association Database (GAD): CCL20
Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

Export disorders for CCL20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCL20 gene, integrated from 10 sources (see all 360):
(articles sorted by number of sources associating them with CCL20)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)^{1, 2, 3, 9} Hieshima K.... Nomiyama H. (J. Biol. Chem. 1997)
Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)^{1, 2, 3, 9} Nelson R.T.... McColl S.R. (Genomics 2001)
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)^{1, 2, 9} Hoover D.M....Lubkowski J. (J. Biol. Chem. 2002)
Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)^{1, 2, 9} Schutyser E.... Van Damme J. (J. Immunol. 2000)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)^{1, 4} Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6364	HGNC: 10619	AceView: CCL20	Ensembl:ENSG00000115009	euGenes: HUgn6364
ECgene: CCL20	Kegg: 6364	H-InvDB: CCL20

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCL20	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL20

Intellectual Property for CCL20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCL20 gene:
Search GeneIP for patents involving CCL20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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