Aliases for CCL20 Gene
External Ids for CCL20 Gene
Previous HGNC Symbols for CCL20 Gene
Previous GeneCards Identifiers for CCL20 Gene
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL20 Gene
CCL20 (Chemokine (C-C Motif) Ligand 20) is a Protein Coding gene. Diseases associated with CCL20 include hordeolum and stromal keratitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and chemokine activity.
UniProtKB/Swiss-Prot for CCL20 Gene
Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.