CCL20 Gene
protein-coding GIFtS : 62
GCID: GC02 P228678
chemokine (C-C motif) ligand 20 (Previous names: small inducible cytokine subfamily A (Cys-Cys), member... ) (Previous symbol: SCYA20 )
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Aliasesfor CCL20 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chemokine (C-C Motif) Ligand 20 1 2 Macrophage Inflammatory Protein 3 Alpha2 3 LARC1 2 3 5 Small-Inducible Cytokine A202 3 SCYA201 2 3 5 MIP-3-Alpha1 MIP3A2 3 5 CC Chemokine LARC2 3 CKb41 2 Exodus-11 MIP-3a1 2 Beta Chemokine Exodus-12 ST381 2 C-C Motif Chemokine 202 Small Inducible Cytokine Subfamily A (Cys-Cys), Member 201 2 Beta-Chemokine Exodus-13 Liver And Activation-Regulated Chemokine2 3
Export aliases for CCL20 gene to outside databases Previous GC identifers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520
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Summariesfor CCL20 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 Function : Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibitsproliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213 Gene Wiki entry for CCL20
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Genomic Viewsfor CCL20 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCL20 gene promoter: HFH-3 Pax-5 Nkx2-2 NF-kappaB E47 C/EBPalpha FOXI1 Chx10 NF-kappaB1 LyF-1 Other transcription factors Search SABiosciences Chromatin IP Primers for CCL20 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL20
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3 CCL20 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P228678: view genomic region
(about GC identifiers )
Start:
228,678,558 bp from pter
End:
228,682,280 bp from pter
Size:
3,723 bases
Orientation:
plus strand
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Proteinsfor CCL20 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See
protein sequence )Recommended Name: C-C motif chemokine 20 precursor Size : 96 amino acids; 10762 Da
Subunit : Binds to and activate CCR6
Subcellular location : Secreted
3 PDB 3D structures from and Proteopedia for CCL20 :1M8A (3D)
  2HCI (3D)
  2JYO (3D)
 
Secondary accessions : Q53S51 Q99664Alternative splicing : 2 isoforms : P78556-1 P78556-2 Explore the universe of human proteins at neXtProt for CCL20: NX_P78556 Post-translational modifications:
C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes1
View neXtProt modification sites for NX_P78556 CCL20 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001123518.1 NP_004582.1 ENSEMBL proteins: ENSP00000386273 ENSP00000351671 Reactome Protein details: P78556 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
TAS -- GO:0005615 extracellular space
IEA --
CCL20 for ontologies About GeneDecksing CCL20 Antibody Products: Assay Products for CCL20:
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Protein
Domains / Familiesfor CCL20 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CCL20 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P78556 ProtoNet protein and cluster: P78556
1 Blocks protein family : IPB000827 Small chemokine UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 Similarity : Belongs to the intercrine beta (chemokine CC) family
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Functionfor CCL20 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 Function : Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibitsproliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213 Induction : By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA)in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CCL20 (NM_004591 ) Sino Biological Human cDNA Clone for CCL20 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCL20 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCL20
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
CCL20 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for CCL20 :
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Pathways & Interactionsfor CCL20 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/14 super-pathways (see all 14 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 PEDF Induced Signaling 2 TGF-Beta Pathway 3 Class A/1 (Rhodopsin-like receptors) 4 Akt Signaling 5 Rho Family GTPases
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for CCL20 5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL20 (see all 27 )2 GeneGo (Thomson Reuters) Pathways for CCL20 1 BioSystems Pathway for CCL20 5/8
Reactome Pathways for CCL20 (see all 8 )3
Kegg Pathways (Kegg details for CCL20) :
CCL20 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL20 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/158 Interacting proteins for CCL20 (P78556 2 , 3 ENSP00000351671 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 158 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
CCL20 for ontologies About GeneDecksing
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Drugs & Compoundsfor CCL20 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
CCL20 for compounds About GeneDecksing Browse Tocris compounds for CCL20 10/20 Novoseek chemical compound relationships for CCL20 gene (see all 20 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
larc
95.7
108
9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32 )
mip-3alpha
86.4
9
15069060 (7), 11352563 (1), 17928889 (1)
tarc
76.2
12
9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9 )
ccl3
76.1
11
18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9 )
rantes
68.8
25
18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22 )
ccl4
60
15
18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13 )
flagellin
51.8
8
15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5 )
il-12
43.4
1
15860229 (1)
poly(i-c)
33
1
16911361 (1)
imac
32
7
16034074 (4)
Search CenterWatch for drugs/clinical trials and news about CCL20
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Transcriptsfor CCL20 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCL20 gene (2 alternative transcripts): NM_001130046.1 NM_004591.2 Unigene Cluster for CCL20:
Chemokine (C-C motif) ligand 20 Hs.75498 [show with all ESTs ] Unigene Representative Sequence: BC020698 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000409189 (uc002vpl.2 uc002vpm.2 ) ENST00000489160 ENST00000358813 ENST00000473642 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CCL20 (NM_004591 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCL20 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCL20
Additional cDNA sequence: BC020698.1 D86955.1 U64197.1 U77035.1
5 DOTS entries : DT.211225 DT.95102901
DT.100777315 DT.91717429 DT.100777317 24/76 AceView cDNA sequences (see all 76 ):
AA297433 AA983599 D17012 BM833314 AW965098 AW168095 D17181 CD640247 BM955557 BM955559 BG534134 CD523297 CD521287 CD641783 AA514362 AI285199 AI718638 D86955 BM956129 BM955558 U77035 AU185348 NM_004591 AW084987 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b SP1 :     -         SP2 :     -         SP3 :            
ECgene alternative splicing isoforms for CCL20
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Expression for CCL20 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCL20 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAGGGTTTAG
About this image CCL20 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CCL20 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCL20 SOURCE GeneReport for Unigene cluster: Hs.75498 UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 Tissue specificity : Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, andfetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon SABiosciences Expression via Pathway-Focused PCR Arrays including CCL20 (see all 8 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCL20Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCL20 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCL20 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL20 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20
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Orthologsfor CCL20 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CCL20 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for CCL20 (if available)TreeFam Gene Tree for CCL20 (if available)
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Paralogsfor CCL20 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor CCL20 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CCL20 1 CNV : 32395
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCL20
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Disorders
/ Diseasesfor CCL20 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCL20 for disorders About GeneDecksing
OMIM gene information: 601960
OMIM disorders : --20/71 diseases for CCL20 (see all 71 ): About MalaCards middle ear cholesteatoma inflammatory bowel disease hordeolum chronic obstructive pulmonary disease smallpox intrauterine infections obstructive jaundice acute liver failure cystic fibrosis allergic rhinitis peripheral t-cell lymphoma cholesteatoma atopic dermatitis jaundice rheumatoid arthritis pulmonary disease hepatitis c periodontal disease ulcerative colitis viral hepatitis 3 diseases from the University of Copenhagen DISEASES database for CCL20 :Psoriasis Hordeolum Inflammatory bowel disease 10/32 Novoseek disease relationships for CCL20 gene (see all 32 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation
57.2
25
17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19 )
necrosis
56.7
34
16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32 )
inflammatory bowel diseases
49.3
11
12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7 )
psoriasis
48.2
14
15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5 )
tumors
38.9
63
19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37 )
dermatitis atopic
35.6
2
11133838 (1), 17369706 (1)
rheumatoid arthritis
34.1
10
19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7 )
colitis ulcerative
30.1
4
12427784 (2), 16306769 (1), 18340639 (1)
pathological processes
22.7
1
12356943 (1)
skin lesion
19.9
2
15315355 (1), 19659772 (1)
Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents) Export disorders for CCL20 gene to outside databases
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Publicationsfor CCL20 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCL20 gene, integrated from 9 sources (see all 348 ) (see top 10 ): (articles sorted by number of sources associating them with CCL20) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201) 1 , 2 , 3, 9 Hieshima K.... Nomiyama H. (1997) Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563) 1 , 2 , 3, 9 Nelson R.T.... McColl S.R. (2001) The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255) 1 , 2 , 9 Hoover D.M....Lubkowski J. (2002) Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086) 1 , 2 , 9 Schutyser E.... Van Damme J. (2000) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939) 1 , 2 Rossi D.L.... Zlotnik A. (1997) Cloning and characterization of Exodus, a novel beta-chemokine. (PubMed id 9129037) 1 , 2 Hromas R.A.... Klemsz M.J. (1997) Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like syno vial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modi fying antirheumatic drugs. (PubMed id 19797510) 1 , 9 Kawashiri S.Y....Eguchi K. (2009) Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. (PubMed id 18980993) 1 , 9 Chang K.P....Yu J.S. (2008) CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients. (PubMed id 17133360) 1 , 9 Lisignoli G....Facchini A. (2007) Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. (PubMed id 16215992) 1 , 9 Brand S....Dambacher J. (2006) Selective early production of CCL20, or macrophage inflammatory protein 3alpha, by human mast cells in response to Pseudomonas aeruginosa. (PubMed id 12496186) 1 , 9 Lin T.J....Marshall J.S. (2003) Increased serum levels of macrophage inflammatory protein-3alpha in hepatocellular carcinoma: relationship with clinical factors and prognostic importance during therapy. (PubMed id 12684696) 1 , 9 Yamauchi K....Onji M. (2003) Production of macrophage inflammatory protein-3alpha in human follicular fluid and cultured granulosa cells. (PubMed id 15474097) 1 , 9 Kawano Y....Miyakawa I. (2004) Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. (PubMed id 19350575) 1 , 9 Kanda N....Watanabe S. (2009) Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis. (PubMed id 18512817) 1 , 9 Bosco M.C....Varesio L. (2008) Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages. (PubMed id 16034074) 1 , 9 Hausmann M....Rogler G. (2005) Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. (PubMed id 12427784) 1 , 9 Kwon J.H....Keates A.C. (2002) Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma. (PubMed id 12239608) 1 , 9 Kimura T....Ushio Y. (2002) Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC. (PubMed id 9169459) 1 , 9 Baba M.... Yoshie O. (1997) Interaction between CXCR4 and CCL20 pathways regulates tumor growth. (PubMed id 19340288) 1 , 9 Beider K....Peled A. (2009) Chlamydophila pneumoniae triggers release of CCL20 an d vascular endothelial growth factor from human bronchial epithelial cells thro ugh enhanced intracellular oxidative stress and MAPK activation. (PubMed id 19479364) 1 , 9 Kim T.B....Cho Y.S. (2009) Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties. (PubMed id 18086840) 1 , 9 Chan D.I....Vogel H.J. (2008) Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells. (PubMed id 12821122) 1 , 9 Shiba H....Kurihara H. (2003) Induction of CCL20 production by Kaposi sarcoma-assoc iated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. (PubMed id 19324905) 1 , 9 Punj V....Chaudhary P.M. (2009) Seminal plasma promotes the attraction of Langerhans cells via the secretion of CCL20 by vaginal epithelial cells: involvement in the sexual transmission of HIV. (PubMed id 16531471) 1 , 9 Berlier W....Delezay O. (2006) MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. (PubMed id 15069060) 1 , 9 Rhee S.H....Pothoulakis C. (2004) ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. (PubMed id 12414801) 1 , 9 Kwon J.H....Keates A.C. (2003) Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. (PubMed id 10064080) 1 , 9 Tanaka Y....Yoshie O. (1999) Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis. (PubMed id 17562763) 1 , 9 Wu Y.Y....Hsu P.N. (2007) A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. (PubMed id 17241869) 1 , 9 Caruso R....Monteleone G. (2007) Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells. (PubMed id 17295217) 1 , 9 Marcet B....Communi D. (2007) Expression of macrophage inflammatory protein-3alpha in an endometrial epithelial cell line, HHUA, and cultured human endometrial stromal cells. (PubMed id 12356943) 1 , 9 Sun B....Miyakawa I. (2002) Increased serum levels of macrophage inflammatory protein-3alpha in chronic viral hepatitis: prognostic importance of macrophage inflammatory protein-3alpha during interferon therapy in chronic hepatitis C. (PubMed id 12010510) 1 , 9 Yamauchi K....Onji M. (2002) Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. (PubMed id 10601351) 1 , 9 Charbonnier A.S....Maurer D. (1999) CCL20/CCR6 expression profile in pancreatic cancer. (PubMed id 20459729) 1 , 9 Rubie C....Schilling M.K. (2010) Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis. (PubMed id 19006683) 1 , 9 Yoshida A....Kohno S. (2009) Adipocyte culture medium stimulates invasiveness of M DA-MB-231 cell via CCL20 production. (PubMed id 19885605) 1 , 9 Kim K.Y....Yang Y. (2009) Macrophage-inflammatory protein-3alpha mediates epidermal growth factor receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin. (PubMed id 17548638) 1 , 9 Keates S....Keates A.C. (2007) BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially. (PubMed id 11877260) 1 , 9 Casamayor-Palleja M....Defrance T. (2002) Differentiated keratinocytes are responsible for TNF-alpha regulated production of macrophage inflammatory protein 3alpha/CCL20, a potent chemokine for Langerhans cells. (PubMed id 11532377) 1 , 9 Tohyama M....Hashimoto K. (2001) Regulation of the psoriatic chemokine CCL20 by E3 lig ases Trim32 and Piasy in keratinocytes. (PubMed id 20054338) 1 , 9 Liu Y....Kulesz-Martin M.F. (2010) Enhanced expression and clinical significance of CC-chemokine MIP-3 alpha in hepatocellular carcinoma. (PubMed id 16764701) 1 , 9 Rubie C....Schilling M. (2006) Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases. (PubMed id 17075975) 1 , 9 Rubie C....Schilling M. (2006) Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. (PubMed id 15679580) 1 , 9 Spiekstra S.W....Gibbs S. (2005) Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells. (PubMed id 9294137) 1 , 9 Power C.A....Wells T.N. (1997) CCL20/CCR6 chemokine/receptor expression in bone tiss ue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups. (PubMed id 19492413) 1 , 9 Lisignoli G....Facchini A. (2009) HIV type 1 glycoprotein 120 inhibits human B cell che motaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL 21. (PubMed id 15972662) 1 , 9 Badr G....Richard Y. (2005) Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes. (PubMed id 14714554) 1 , 9 Pernet I....Viac J. (2003) Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. (PubMed id 11133838) 1 , 9 Nakayama T....Yoshie O. (2001) Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6. (PubMed id 10438902) 1 , 9 Yang D....Oppenheim J.J. (1999) STRL22 is a receptor for the CC chemokine MIP-3alpha. (PubMed id 9223454) 1 , 9 Liao F....Farber J.M. (1997) Modulation of expression of innate immunity markers C XCL5/ENA-78 and CCL20/MIP3alpha by protease-activated receptors (PARs) in human gingival epithelial cells. (PubMed id 19567485) 1 , 9 Rohani M.G....Chung W.O. (2010) CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells. (PubMed id 19233848) 1 , 9 Vongsa R.A....Dwinell M.B. (2009) Th17 cytokines stimulate CCL20 expression in keratino cytes in vitro and in vivo: implications for psoriasis pathogenesis. (PubMed id 19295614) 1 , 9 Harper E.G....Blauvelt A. (2009) CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions. (PubMed id 18703490) 1 , 9 Giuliani N....Rizzoli V. (2008) Chemokine redundancy in BOS pathogenesis. A possible role also for the CC chemokines: MIP3-beta, MIP3-alpha, MDC and their specific receptors. (PubMed id 18047937) 1 , 9 Meloni F....Fietta A.M. (2008) Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue. (PubMed id 15671814) 1 , 9 Nakanishi T....Matsuo T. (2005) Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function. (PubMed id 11994140) 1 , 9 Schmuth M....Heufler C. (2002) Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. (PubMed id 10521347) 1 , 9 Yang D....Oppenheim J.J. (1999) ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. (PubMed id 23011799) 1 Miller M....Broide D.H. (2012) The role of chemokine CC ligand 20 in patients with li ver cirrhosis and hepatocellular carcinoma. (PubMed id 22388957) 1 Soliman H.H....Alm El-Din M.A. (2012) MIP-3a expression in macrophages is NOD dependent. (PubMed id 22286692) 1 Hausmann M....Rogler G. (2012) miR-21 functionally interacts with the 3'UTR of chemok ine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal c ancer cells. (PubMed id 22099878) 1 Vicinus B....Schilling M.K. (2012) Human keratinocytes' response to injury upregulates C CL20 and other genes linking innate and adaptive immunity. (PubMed id 21881590) 1 Kennedy-Crispin M....Krueger J.G. (2012) Human papillomavirus type 8 interferes with a novel C/ EBPb-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhan s cell migration. (PubMed id 22911498) 1 Sperling T....Smola S. (2012) MiR-21 is involved in cervical squamous cell tumorigen esis and regulates CCL20. (PubMed id 22001440) 1 Yao T. and Lin Z. (2012) CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents. (PubMed id 22857950) 1 Ouwehand K....Gibbs S. (2012) PI16 is expressed by a subset of human memory Treg wit h enhanced migration to CCL17 and CCL20. (PubMed id 22533972) 1 Nicholson I.C....Krumbiegel D. (2012) Brucella invasion of human intestinal epithelial cells elicits a weak proinflammatory response but a significant CCL20 secretion. (PubMed id 22553918) 1 Ferrero M.C....Baldi P.C. (2012) Interleukin (IL)-17A synergistically enhances CC chemo kine ligand 20 production in IL-1b-stimulated human gingival fibroblasts. (PubMed id 22019504) 1 Hosokawa Y....Matsuo T. (2012) Epigenetic regulation of human I^-defensin 2 and CC ch emokine ligand 20 expression in gingival epithelial cells in response to oral b acteria. (PubMed id 21248725) 1 Yin L. and Chung W.O. (2011) IL-22, but not IL-17, dominant environment in cutaneou s T-cell lymphoma. (PubMed id 22048239) 1 Miyagaki T....Sato S. (2011) CCL20 and I^-defensin-2 induce arrest of human Th17 ce lls on inflamed endothelium in vitro under flow conditions. (PubMed id 21178014) 1 Ghannam S....PA"ne J. (2011) Fusobacterium nucleatum and human beta-defensins modu late the release of antimicrobial chemokine CCL20/macrophage inflammatory prote in 3I+. (PubMed id 21911466) 1 Ghosh S.K....Weinberg A. (2011) Chemokine (C-C) motif ligand 20 is regulated by PGF(2 I+)-F-prostanoid receptor signalling in endometrial adenocarcinoma and promotes cell proliferation. (PubMed id 20816914) 1 Wallace A.E....Jabbour H.N. (2011) Effect of preoperative FOLFOX chemotherapy on CCL20/C CR6 expression in colorectal liver metastases. (PubMed id 21912453) 1 Rubie C....Schilling M.K. (2011) CCL20 stimulates proinflammatory mediator synthesis in human fibroblast-like synoviocytes through a MAP kinase-dependent process with transcriptional and posttranscriptional control. (PubMed id 21724701) 1 Alaaeddine N....Di Battista J.A. (2011) Control of cell migration and inflammatory mediators p roduction by CORM-2 in osteoarthritic synoviocytes. (PubMed id 21961038) 1 Garcia-Arnandis I....Alcaraz M.J. (2011) Selective recruitment of regulatory T cell through CCR 6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. (PubMed id 21935436) 1 Chen K.J....Zheng S.S. (2011) CCL20/CCR6 feedback exaggerates epidermal growth fact or receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H 292) cells. (PubMed id 21300824) 1 Kim S....Nadel J.A. (2011) Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression. (PubMed id 21949768) 1 Kirshberg S....Wald O. (2011) Exogenous HIV-1 Nef upsets the IFN-g-induced impairmen t of human intestinal epithelial integrity. (PubMed id 21858117) 1 Quaranta M.G....Viora M. (2011) Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964) 1 Rajaraman P....Inskip P.D. (2010) Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785) 1 Han S....Kang D. (2010) Chemokine-mediated distribution of dendritic cell sub sets in renal cell carcinoma. (PubMed id 20969772) 1 Middel P....Radzun H.J. (2010) CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce anti-tumor immunity against gastric cancer ex vi vo and in vivo. (PubMed id 20420712) 1 He S....Zhang Y. (2010) Response of corneal epithelial cells to Staphylococcu s aureus. (PubMed id 21178448) 1 Heimer S.R....Gilmore M. (2010) CCR6 ligands inhibit HIV by inducing APOBEC3G. (PubMed id 20023216) 1 Lafferty M.K....Garzino-Demo A. (2010) Oxidative stress enhances IL-8 and inhibits CCL20 pro duction from intestinal epithelial cells in response to bacterial flagellin. (PubMed id 20595617) 1 Ivison S.M....Steiner T.S. (2010) Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer. (PubMed id 20439195) 1 Raynaud C.M....Soria J.C. (2010) Mesenchymal stem cells inhibit human Th17 cell differ entiation and function and induce a T regulatory cell phenotype. (PubMed id 20511548) 1 Ghannam S....Yssel H. (2010) Chemokine control of HIV-1 infection: beyond a binding competition. (PubMed id 20942936) 1 Wu Y. (2010) OX40 induces CCL20 expression in the context of antig en stimulation: an expanding role of co-stimulatory molecules in chemotaxis. (PubMed id 20400327) 1 Zhong W....Rosenbaum J.T. (2010) Higher levels of CCL20 expression on peripheral blood mononuclear cells of chinese patients with inflammatory bowel disease. (PubMed id 20064082) 1 He C....Li Y.Z. (2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) CCL20 is overexpressed in Mycobacterium tuberculosis- infected monocytes and inhibits the production of reactive oxygen species (ROS) . (PubMed id 20819093) 1 Rivero-Lezcano O.M....Diez-TascA^n C. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) Upregulation of chemokine (C-C motif) ligand 20 in ad ult epidermal keratinocytes in direct current electric fields. (PubMed id 19784662) 1 Jennings J.A....Feldman D.S. (2010) Toll-like receptor 5- and lymphotoxin beta receptor-d ependent epithelial Ccl20 expression involves the same NF-kappaB binding site b ut distinct NF-kappaB pathways and dynamics. (PubMed id 19303953) 1 Sirard J.C....Rumbo M. (2009) Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540) 1 Rajaraman P....Chanock S.J. (2009) C-C chemokine receptor 6-regulated entry of TH-17 cel ls into the CNS through the choroid plexus is required for the initiation of EA E. (PubMed id 19305396) 1 Reboldi A....Sallusto F. (2009) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. (PubMed id 18757306) 1 Medoff B.D....Xavier R.J. (2009) Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulator s. (PubMed id 19644053) 1 Duffaut C....BouloumiAc A. (2009) Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029) 1 Luttrell L.M. (2008) Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. (PubMed id 18684866) 1 Lamprecht B....Mathas S. (2008) Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection. (PubMed id 18576931) 1 Hamill N....Hassan S.S. (2008) Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758) 1 Lambert N.A. (2008) Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines. (PubMed id 17356539) 1 Song R....Leong K.W. (2007) Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302) 1 Levy D....Mitchell G.F. (2007) High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism. (PubMed id 17664181) 1 Qi W....Pollock C.A. (2007) [Expression of CCL20 and CXCR4 in epidermal condyloma acuminatum lesions] (PubMed id 17545018) 1 Feng J.Y....Liu Y.P. (2007) Structure of human MIP-3alpha chemokine. (PubMed id 16820679) 1 Malik Z.A. and Tack B.F. (2006) MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection. (PubMed id 16095490) 1 Woltman A.M....van Kooten C. (2005) Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3alpha)-induced dendritic cell migration. (PubMed id 15618437) 1 Thorley A.J....Tetley T.D. (2005) Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro. (PubMed id 15336571) 1 Fujii H....Okanoue T. (2004) Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. (PubMed id 12528183) 1 Ambrosini E....Aloisi F. (2003) Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. (PubMed id 12760962) 1 Reibman J....Gordon T. (2003) Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding. (PubMed id 11994436) 1 Liao F....Farber J.M. (2002) HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. (PubMed id 12089333) 1 Cicala C....Fauci A.S. (2002) Influence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepitheli al lesions of the cervix. (PubMed id 11807793) 1 Giannini S.L....Delvenne P. (2002) Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. (PubMed id 12067311) 1 Hosokawa Y....Matsuo T. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Versican interacts with chemokines and modulates cellular responses. (PubMed id 11083865) 1 Hirose J....Miyasaka M. (2001) The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. (PubMed id 8076819) 1 Matoba R....Matsubara K. (1994) Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion. (PubMed id 15701269) 9 Kimsey T.F....Wang T.N. (2004) Helicobacter pylori induces CCL20 expression. (PubMed id 17724069) 9 Tomimori K....Mori N. (2007) Increase of CCL20 expression by human gingival fibroblasts upon stimulation with cytokines and bacterial endotoxin. (PubMed id 16232215) 9 Hosokawa Y....Matsuo T. (2005) CCL20 is an inducible product of human airway epithelia with innate immune properties. (PubMed id 12748059) 9 Starner T.D....McCray P.B. (2003) Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus. (PubMed id 17141855) 9 Kim B.E....Howell M.D. (2007) Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. (PubMed id 17332482) 9 Demedts I.K....Brusselle G.G. (2007) CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6. (PubMed id 19535263) 9 Tanida S....Nakamura T. (2009) Modulation of pathogen-induced CCL20 secretion from H T-29 human intestinal epithelial cells by commensal bacteria. (PubMed id 19814810) 9 Sibartie S....Shanahan F. (2009) CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines. (PubMed id 18582332) 9 Takahashi K....Matsuo T. (2008) Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritis. (PubMed id 16331752) 9 Schlenk J....Beuscher H.U. (2005) Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (PubMed id 15287366) 9 Shirane J....Yoshie O. (2004) Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium. (PubMed id 15236187) 9 Rumbo M....Finke D. (2004) Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis. (PubMed id 12695561) 9 Ruth J.H....Koch A.E. (2003) MCP-1 and MIP3-alpha serum levels in acute liver failure and molecular adsorbent recirculating system (MARS) treatment: a pilot study. (PubMed id 19247846) 9 Roth G.A....Krenn C.G. (2009) Serum amyloid A protein stimulates CCL20 production i n rheumatoid synoviocytes. (PubMed id 19447772) 9 Migita K....Ishibashi H. (2009) Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells. (PubMed id 17924972) 9 Lee S.K....Kim E.C. (2007) Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis. (PubMed id 17619881) 9 Kageyama Y....Nagano A. (2007) Increased expression of CCL20 in human inflammatory bowel disease. (PubMed id 14997037) 9 Kaser A....Tilg H. (2004) Induction of macrophage-inflammatory protein-3alpha g ene expression by TNF-dependent NF-kappaB activation. (PubMed id 12023359) 9 Sugita S....Matsuyama T. (2002) Iron chelator differentially activates macrophage inflammatory protein-3alpha/CCL20 in immortalized and malignant human oral keratinocytes. (PubMed id 18328460) 9 Lee S.K....Kim E.C. (2008) Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. (PubMed id 18052967) 9 Lee J.S....Jo E.K. (2008) Odontoblast marker gene expression is enhanced by a CC-chemokine family protein MIP-3alpha in human mesenchymal stem cells. (PubMed id 17532291) 9 Iejima D....Ueda M. (2007) Up-regulation of chemokine ligand 20 in chronic rhinosinusitis. (PubMed id 16702571) 9 Lee J.H....Lee H.M. (2006) Iron chelator induces MIP-alpha/CCL20 in human intestinal epithelial cells: implication for triggering mucosal adaptive immunity. (PubMed id 16155407) 9 Lee H.J....Jun C.D. (2005) Increased expression of MIP-3alpha/CCL20 in peripheral blood mononuclear cells from patients with ulcerative colitis and its down-regulation by sulfasalazine and glucocorticoid treatment. (PubMed id 16306769) 9 Lee H.J....Jun C.D. (2005) A combination of MIP-3alpha and TGF-beta1 is required for the attraction of human Langerhans precursor cells through a dermal-epidermal barrier. (PubMed id 11432723) 9 Godefroy S....Staquet M.J. (2001) Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. (PubMed id 10225458) 9 Kleeff J....Korc M. (1999) Macrophage-inflammatory protein-3alpha/CCL-20 is tran scriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaB. (PubMed id 19939449) 9 Varesio L....Bosco M.C. (2010) Macrophage inflammatory protein-3alpha promotes pancreatic cancer cell invasion. (PubMed id 15652956) 9 Campbell A.S....Wang T.N. (2005) Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis. (PubMed id 12667656) 9 Chevrel G....Miossec P. (2003) Effects of leptin on the production of cytokines by cultured human endometrial stromal and epithelial cells. (PubMed id 14505754) 9 Fukuda J....Miyakawa I. (2003) Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. (PubMed id 11254498) 9 Izadpanah A....Kagnoff M.F. (2001) Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines. (PubMed id 11698482) 9 Chabaud M....Miossec P. (2001) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. (PubMed id 9886385) 9 Liao F....Farber J.M. (1999) Increased migration of Langerhans cells in response to HPV16 E6 and E7 oncogene silencing: role of CCL20. (PubMed id 18438663) 9 Caberg J.H....Delvenne P. (2009) Catechins inhibit CCL20 production in IL-17A-stimulat ed human gingival fibroblasts. (PubMed id 19910679) 9 Hosokawa Y....Matsuo T. 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(2005) An optimized method for intensive screening of molecules that stimulate beta-defensin 2 or 3 (hBD2 or hBD3) expression in cultured normal human keratinocytes. (PubMed id 18492183) 9 Pernet I....Perrier E. (2005) The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094) 9 De Ceuninck F....Anract P. (2004) Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. (PubMed id 15009427) 9 Niyonsaba F....Nagaoka I. (2004) Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection. (PubMed id 15257040) 9 Krukemeyer M.G....Krenn V. (2004) Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines. (PubMed id 15352210) 9 Yabe T....Schwartz J.P. 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(2003) LPS and Freund's adjuvant initiate different inflammatory circuits in experimental autoimmune thyroiditis. (PubMed id 12799214) 9 Damotte D....Carnaud C. (2003) IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. (PubMed id 11884467) 9 Zhu Z....Elias J.A. (2002) CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas. (PubMed id 12514792) 9 Rodig S.J....Dorfman D.M. (2002) Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells. (PubMed id 12147625) 9 Corcione A....Pistoia V. (2002) Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. (PubMed id 11897677) 9 Liu D....Eizirik D.L. (2002) Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood. (PubMed id 11792124) 9 Wakahara S....Ra C. (2001) Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach. (PubMed id 11576227) 9 Ragno S....Colston M.J. (2001) Identification, mapping, and phylogenetic analysis of three novel chicken CC chemokines. (PubMed id 11797102) 9 Hughes S....Bumstead N. (2001) Angioimmunoblastic lymphadenopathy-type peripheral T-cell lymphoma with cutaneous infiltration: report of a case and its gene expression profile. (PubMed id 11298554) 9 Murakami T....Nakagawa H. (2001) Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. (PubMed id 11717433) 9 Sierro F....Sirard J.C. (2001) Chemokine receptor expressions and responsiveness of cord blood T cells. (PubMed id 11160208) 9 Sato K....Takahashi T. (2001) Selective attraction of naive and memory B cells by dendritic cells. (PubMed id 11590201) 9 Dubois B....Caux C. (2001) TGF-beta 1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. (PubMed id 10679062) 9 Sato K....Takahashi T.A. (2000) Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS. (PubMed id 10781900) 9 Nelissen J.M....Figdor C.G. (2000) Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE. (PubMed id 11001915) 9 Suzuki T....Matsushima K. (2000) Expression of CCR6 and CD83 by cytokine-activated human neutrophils. (PubMed id 11090084) 9 Yamashiro S....Yoshimura T. (2000) Papillary carcinoma of the thyroid: hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells. (PubMed id 10702399) 9 Scarpino S....Ruco L.P. (2000) Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. (PubMed id 10934220) 9 Tilton B....Thelen M. (2000)
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PharmGKB entry for CCL20 Pharmacogenomics, SNPs, Pathways Wikipedia http://en.wikipedia.org/wiki/CCL20
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About This Section Patent Information for CCL20 gene: Search GeneIP for patents involving CCL20 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCL20 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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Browse OriGene Antibodies OriGene shRNA RFP for CCL20 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCL20 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCL20 OriGene Protein Over-expression Lysate for CCL20 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCL20 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCL20 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCL20 OriGene Custom Protein Services for CCL20 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL20 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCL20 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL20 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCL20 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL20 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCL20
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Recombinant Protein for CCL20
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20
ThermoFisher Antibodies for CCL20
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCL20
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