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CCL20 Gene

protein-coding   GIFtS: 65
GCID: GC02P228678

Chemokine (C-C Motif) Ligand 20

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 2...)
(Previous symbol: SCYA20)
  See CCL20-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Chemokine (C-C Motif) Ligand 201 2     MIP-3-alpha2 3
SCYA201 2 3 5     CC Chemokine LARC2 3
LARC2 3 5     CKb42
MIP3A2 3 5     MIP-3a2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 201 2     ST382
Liver And Activation-Regulated Chemokine2 3     Beta Chemokine Exodus-12
Macrophage Inflammatory Protein 3 Alpha2 3     C-C Motif Chemokine 202
Small-Inducible Cytokine A202 3     Beta-Chemokine Exodus-13

External Ids:    HGNC: 106191   Entrez Gene: 63642   Ensembl: ENSG000001150097   OMIM: 6019605   UniProtKB: P785563   
ORGUL members:         

Export aliases for CCL20 gene to outside databases

Previous GC identifiers: GC02P226699 GC02P227410 GC02P228642 GC02P228881 GC02P228504 GC02P228386 GC02P220520

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCL20 Gene:
CCL20 (chemokine (C-C motif) ligand 20) is a protein-coding gene. Diseases associated with CCL20 include smallpox, and pancreatic cancer. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
activity E.coli ATCC 25922 and S.aureus ATCC 29213

Gene Wiki entry for CCL20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL20 gene promoter:
         HFH-3   Pax-5   Nkx2-2   NF-kappaB   E47   C/EBPalpha   FOXI1   Chx10   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL20 promoter sequence
   Search Chromatin IP Primers for CCL20

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

CCL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL20 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P228678:  view genomic region     (about GC identifiers)

228,678,558 bp from pter      End:
228,682,280 bp from pter
3,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556 (See protein sequence)
Recommended Name: C-C motif chemokine 20 precursor  
Size: 96 amino acids; 10762 Da
Subunit: Binds to and activate CCR6
3 PDB 3D structures from and Proteopedia for CCL20:
1M8A (3D)        2HCI (3D)        2JYO (3D)    
Secondary accessions: Q53S51 Q99664
Alternative splicing: 2 isoforms:  P78556-1   P78556-2   

Explore the universe of human proteins at neXtProt for CCL20: NX_P78556

Explore proteomics data for CCL20 at MOPED

Post-translational modifications: 

  • C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion
    from peripheral blood monocytes1
  • Modification sites at neXtProt

  • See CCL20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123518.1  NP_004582.1  

    ENSEMBL proteins: 
     ENSP00000386273   ENSP00000351671  
    Reactome Protein details: P78556

    CCL20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL20 (CCL20/MIP-3 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL20
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL20
    GenScript Purified and Recombinant Proteins for CCL20
    Novus Biologicals CCL20 Proteins
    Novus Biologicals CCL20 Lysates
    Sino Biological Recombinant Protein for CCL20
    Sino Biological Cell Lysate for CCL20
    ProSpec Recombinant Protein for CCL20
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for CCL20 

    antibodies-online proteins for CCL20 (64 products) 

    antibodies-online peptides for CCL20

    GeneTex Proteins for CCL20: (see all 2
                        MIP-3 alpha Recombinant Protein (Active) (GTX48366-PRO)

    CCL20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL20 (CCL20/MIP-3 alpha)
    OriGene Antibodies for CCL20
    OriGene Custom Antibody Services for CCL20
    Novus Biologicals CCL20 Antibodies
    Abcam antibodies for CCL20
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL20
    antibodies-online antibodies for CCL20 (105 products) 

    GeneTex Antibodies for CCL20:  
                        CCL20 Antibodies

    CCL20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL20
    R&D Systems ELISAs for CCL20 (CCL20/MIP-3 alpha)         (see all)
    GenScript Custom Assay Services for CCL20
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL20 
    antibodies-online kits for CCL20 (50 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P78556

    ProtoNet protein and cluster: P78556

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Similarity: Belongs to the intercrine beta (chemokine CC) family

    Find genes that share domains with CCL20           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL20_HUMAN, P78556
    Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits
    proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the
    mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal
    processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial
    activity E.coli ATCC 25922 and S.aureus ATCC 29213
    Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate
    (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005515protein binding IPI17703191
    GO:0008009chemokine activity IEA--
    Find genes that share ontologies with CCL20           About GenesLikeMe

         1 GenomeRNAi human phenotype for CCL20:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL20

        Taconic Biosciences Mouse Models for CCL20:  
                        TF3194 - Ccl20

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for CCL20

    miRTarBase miRNAs that target CCL20:
    hsa-mir-335-5p (MIRT017837), hsa-mir-21-5p (MIRT006199)

    Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CCL20:
    hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidCCL20 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for CCL20
    Predesigned siRNA for gene silencing in human, mouse, rat CCL20

    OriGene clones in human, mouse for CCL20 (see all 11)
    OriGene ORF clones in mouse, rat for CCL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
    Sino Biological Human cDNA Clone for CCL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20

    Cell Line
    GenScript Custom overexpressing Cell Line Services for CCL20
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL20 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    CCL20_HUMAN, P78556: Secreted
    Subcellular locations from COMPARTMENTS: 


    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL20           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for CCL20 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44

    Find genes that share SuperPaths with CCL20           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL20
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL20 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for CCL20
        Immune response TLR signaling pathways
    Bacterial infections in CF airways

    1 BioSystems Pathway for CCL20
        EBV LMP1 signaling

    2 Reactome Pathways for CCL20
        Chemokine receptors bind chemokines
    G alpha (i) signalling events

    4 Kegg Pathways  (Kegg details for CCL20):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway
    Rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL20 (see all 8): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat


        GeneGlobe Interaction Network for CCL20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL20 (P785561, 2, 3 ENSP000003516714) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K32, 3MINT-6505246 I2D: score=1 
    RALBP1Q153111, 2, 3, ENSP000000193174EBI-3913209,EBI-749285 MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000019317
    CCR6P516843, ENSP000003393934I2D: score=3 STRING: ENSP00000339393
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    CTSBP078583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10438902
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9038201
    GO:0007267cell-cell signaling TAS9038201

    Find genes that share ontologies with CCL20           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL20

    Selected Novoseek inferred chemical compound relationships for CCL20 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    larc 95.7 108 9038201 (8), 9169459 (8), 12239608 (7), 10064080 (6) (see all 32)
    mip-3alpha 86.4 9 15069060 (7), 11352563 (1), 17928889 (1)
    tarc 76.2 12 9365118 (3), 9153236 (1), 12799214 (1), 11001915 (1) (see all 9)
    ccl3 76.1 11 18565769 (2), 18625197 (1), 19001077 (1), 17369706 (1) (see all 9)
    rantes 68.8 25 18492658 (3), 11022002 (2), 11160208 (1), 11797102 (1) (see all 22)
    ccl4 60 15 18565769 (2), 18625197 (1), 19120450 (1), 17369706 (1) (see all 13)
    flagellin 51.8 8 15069060 (3), 19814810 (2), 11717433 (1), 20471126 (1) (see all 5)
    il-12 43.4 1 15860229 (1)
    poly(i-c) 33 1 16911361 (1)
    imac 32 7 16034074 (4)

    Find genes that share compounds with CCL20           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for CCL20 gene (2 alternative transcripts): 
    NM_001130046.1  NM_004591.2  

    Unigene Cluster for CCL20:

    Chemokine (C-C motif) ligand 20
    Hs.75498  [show with all ESTs]
    Unigene Representative Sequence: BC020698
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409189(uc002vpl.2 uc002vpm.2) ENST00000489160 ENST00000358813
    Block miRNA regulation of human, mouse, rat CCL20 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CCL20:
    hsa-miR-3163 hsa-miR-21 hsa-miR-590-5p hsa-miR-330-3p hsa-miR-15b* hsa-miR-1322 hsa-miR-635 hsa-miR-1272
    SwitchGear 3'UTR luciferase reporter plasmidCCL20 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for CCL20
    Predesigned siRNA for gene silencing in human, mouse, rat CCL20
    OriGene clones in human, mouse for CCL20 (see all 11)
    OriGene ORF clones in mouse, rat for CCL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL20 (NM_004591)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL20
    OriGene qPCR primer pairs and template standards for CCL20
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL20
      QuantiTect SYBR Green Assays in human, mouse, rat CCL20
      Search QuantiFast Probe-based Assays in human, mouse, rat CCL20

    Additional mRNA sequence: 

    BC020698.1 D86955.1 U64197.1 U77035.1 

    5 DOTS entries:

    DT.211225  DT.95102901  DT.100777315  DT.91717429  DT.100777317 

    Selected AceView cDNA sequences (see all 76):

    BM833314 D17012 AA983599 D17181 AW965098 AA297433 AW168095 CD365673 
    CD641783 CD523297 AW072796 BM956130 AA527293 U77035 AW014484 BG563672 
    AU185348 AI285199 BE439997 D86955 BM955557 BG950969 AW084987 BC020698 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCL20    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:              -                     
    SP2:              -                     

    ECgene alternative splicing isoforms for CCL20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CCL20 Expression
    About this image

    CCL20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     Lung (Respiratory System)
             Alveolar type II cells
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     Colon (Gastrointestinal Tract)
     Tonsil (Hematopoietic System)
    CCL20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75498

    UniProtKB/Swiss-Prot: CCL20_HUMAN, P78556
    Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and
    fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL20 (see all 8): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    OriGene qPCR primer pairs and template standards for CCL20
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL20
    QuantiTect SYBR Green Assays in human, mouse, rat CCL20
    Search QuantiFast Probe-based Assays in human, mouse, rat CCL20
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL20 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ccl201 , 5 chemokine (C-C motif) ligand 201, 5 72.7(n)1
      1 (42.69 cM)5
    202971  NM_016960.21  NP_058656.11 
    (Gallus gallus)
    Aves CCL201 chemokine (C-C motif) ligand 20 61.96(n)
      395082  NM_204438.2  NP_989769.1 
    (Anolis carolinensis)
    Reptilia CCL206
    chemokine (C-C motif) ligand 20
    1 ↔ 1

    ENSEMBL Gene Tree for CCL20 (if available)
    TreeFam Gene Tree for CCL20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for CCL20 gene
    18 SIMAP similar genes for CCL20 using alignment to 1 protein entry:     CCL20_HUMAN:
    CCL16    CCL26    CCL2    CCL21    CCL11    CCL18
    CCL23    CCL3    CCL4    CCL3L1    CCL3L3    CCL5
    CCL7    MCP-3    CCL8    CCL24    IL8    LOC728835

    Find genes that share paralogs with CCL20           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for CCL20 (see all 168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 2 posSequence#AA
    --228676559(+) GTTGGC/TCAGGT 2 -- us2k10--------
    C,F--228676591(+) CGGCTC/TGCCGT 2 -- us2k11Minor allele frequency- T:0.08EA 120
    C,F,H--228676594(+) ctcgcC/Tgtaac 2 -- us2k113Minor allele frequency- T:0.35NS EA NA WA CSA 784
    --228676769(+) CACCTC/TGGCCT 2 -- us2k10--------
    C--228676770(+) ACCTCA/GGCCTC 2 -- us2k10--------
    --228676796(+) TACAGG/TCATGA 2 -- us2k10--------
    C,F--228676856(+) CTTTCT/CGTCTG 2 -- us2k11Minor allele frequency- C:0.04WA 118
    C--228676922(+) CAGTCG/AGTTTA 2 -- us2k15Minor allele frequency- A:0.24NA WA EA 362
    --228676974(+) CCTAGA/GGAACA 2 -- us2k10--------
    --228676976(+) TAGAGA/TACATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL20 (228678558 - 228682280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv10221CNV Loss18304495
    nsv834562CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 601960    OMIM disorders: --

    4 diseases for CCL20:    
    About MalaCards
    smallpox    pancreatic cancer    stromal keratitis    pustulosis palmaris et plantaris

    2 inferred disease relationships from the University of Copenhagen DISEASES database for CCL20:
    Psoriasis     Inflammatory bowel disease

    Find genes that share disorders with CCL20           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL20 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 57.2 25 17272517 (3), 16215992 (2), 10974036 (2), 12821122 (1) (see all 19)
    necrosis 56.7 34 16232215 (1), 17068485 (1), 18492658 (1), 16045736 (1) (see all 32)
    inflammatory bowel diseases 49.3 11 12427784 (4), 14997037 (1), 16306769 (1), 17272517 (1) (see all 7)
    psoriasis 48.2 14 15315354 (3), 15315355 (2), 19295614 (2), 10843722 (1) (see all 5)
    tumors 38.9 63 19340288 (5), 15470034 (3), 15652956 (3), 18465142 (2) (see all 37)
    dermatitis atopic 35.6 2 11133838 (1), 17369706 (1)
    rheumatoid arthritis 34.1 10 19535263 (2), 17619881 (2), 17133360 (2), 19797510 (1) (see all 7)
    colitis ulcerative 30.1 4 12427784 (2), 16306769 (1), 18340639 (1)
    pathological processes 22.7 1 12356943 (1)
    skin lesion 19.9 2 15315355 (1), 19659772 (1)

    Genetic Association Database (GAD): CCL20
    Human Genome Epidemiology (HuGE) Navigator: CCL20 (9 documents)

    Export disorders for CCL20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL20 gene, integrated from 10 sources (see all 360) (see top 10):
    (articles sorted by number of sources associating them with CCL20)

    1. Molecular cloning of a novel human CC chemokine liver and activation- regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PubMed id 9038201)1, 2, 3, 9 Hieshima K.... Nomiyama H. (J. Biol. Chem. 1997)
    2. Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PubMed id 11352563)1, 2, 3, 9 Nelson R.T.... McColl S.R. (Genomics 2001)
    3. The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PubMed id 12149255)1, 2, 9 Hoover D.M....Lubkowski J. (J. Biol. Chem. 2002)
    4. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PubMed id 11035086)1, 2, 9 Schutyser E.... Van Damme J. (J. Immunol. 2000)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)1, 4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    11. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939)1, 2 Rossi D.L.... Zlotnik A. (J. Immunol. 1997)
    12. Cloning and characterization of Exodus, a novel beta-chemokine. (PubMed id 9129037)1, 2 Hromas R.A.... Klemsz M.J. (Blood 1997)
    13. Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs. (PubMed id 19797510)1, 9 Kawashiri S.Y....Eguchi K. (J. Rheumatol. 2009)
    14. Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. (PubMed id 18980993)1, 9 Chang K.P....Yu J.S. (Clin. Cancer Res. 2008)
    15. CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients. (PubMed id 17133360)1, 9 Lisignoli G....Facchini A. (J. Cell. Physiol. 2007)
    16. Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. (PubMed id 16215992)1, 9 Brand S....Dambacher J. (J. Cell. Biochem. 2006)
    17. Selective early production of CCL20, or macrophage inflammatory protein 3alpha, by human mast cells in response to Pseudomonas aeruginosa. (PubMed id 12496186)1, 9 Lin T.J....Marshall J.S. (Infect. Immun. 2003)
    18. Increased serum levels of macrophage inflammatory protein-3alpha in hepatocellular carcinoma: relationship with clinical factors and prognostic importance during therapy. (PubMed id 12684696)1, 9 Yamauchi K....Onji M. (Int. J. Mol. Med. 2003)
    19. Production of macrophage inflammatory protein-3alpha in human follicular fluid and cultured granulosa cells. (PubMed id 15474097)1, 9 Kawano Y....Miyakawa I. (Fertil. Steril. 2004)
    20. Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. (PubMed id 19350575)1, 9 Kanda N....Watanabe S. (Eur. J. Immunol. 2009)
    21. Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis. (PubMed id 18512817)1, 9 Bosco M.C....Varesio L. (Arthritis Rheum. 2008)
    22. Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages. (PubMed id 16034074)1, 9 Hausmann M....Rogler G. (J. Immunol. 2005)
    23. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. (PubMed id 12427784)1, 9 Kwon J.H....Keates A.C. (Gut 2002)
    24. Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma. (PubMed id 12239608)1, 9 Kimura T....Ushio Y. (Int. J. Oncol. 2002)
    25. Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC. (PubMed id 9169459)1, 9 Baba M.... Yoshie O. (J. Biol. Chem. 1997)
    26. Interaction between CXCR4 and CCL20 pathways regulates tumor growth. (PubMed id 19340288)1, 9 Beider K....Peled A. (PLoS ONE 2009)
    27. Chlamydophila pneumoniae triggers release of CCL20 and vascular endothelial growth factor from human bronchial epithelial cells through enhanced intracellular oxidative stress and MAPK activation. (PubMed id 19479364)1, 9 Kim T.B....Cho Y.S. (J. Clin. Immunol. 2009)
    28. Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties. (PubMed id 18086840)1, 9 Chan D.I....Vogel H.J. (Antimicrob. Agents Chemother. 2008)
    29. Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells. (PubMed id 12821122)1, 9 Shiba H....Kurihara H. (Biochem. Biophys. Res. Commun. 2003)
    30. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. (PubMed id 19324905)1, 9 Punj V....Chaudhary P.M. (Blood 2009)
    31. Seminal plasma promotes the attraction of Langerhans cells via the secretion of CCL20 by vaginal epithelial cells: involvement in the sexual transmission of HIV. (PubMed id 16531471)1, 9 Berlier W....DelAczay O. (Hum. Reprod. 2006)
    32. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. (PubMed id 15069060)1, 9 Rhee S.H....Pothoulakis C. (J. Biol. Chem. 2004)
    33. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. (PubMed id 12414801)1, 9 Kwon J.H....Keates A.C. (J. Biol. Chem. 2003)
    34. Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. (PubMed id 10064080)1, 9 Tanaka Y....Yoshie O. (Eur. J. Immunol. 1999)
    35. Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis. (PubMed id 17562763)1, 9 Wu Y.Y....Hsu P.N. (Infect. Immun. 2007)
    36. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. (PubMed id 17241869)1, 9 Caruso R....Monteleone G. (Gastroenterology 2007)
    37. Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells. (PubMed id 17295217)1, 9 Marcet B....Communi D. (J. Cell. Physiol. 2007)
    38. Expression of macrophage inflammatory protein-3alpha in an endometrial epithelial cell line, HHUA, and cultured human endometrial stromal cells. (PubMed id 12356943)1, 9 Sun B....Miyakawa I. (Mol. Hum. Reprod. 2002)
    39. Increased serum levels of macrophage inflammatory protein-3alpha in chronic viral hepatitis: prognostic importance of macrophage inflammatory protein-3alpha during interferon therapy in chronic hepatitis C. (PubMed id 12010510)1, 9 Yamauchi K....Onji M. (J. Viral Hepat. 2002)
    40. Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. (PubMed id 10601351)1, 9 Charbonnier A.S....Maurer D. (J. Exp. Med. 1999)
    41. CCL20/CCR6 expression profile in pancreatic cancer. (PubMed id 20459729)1, 9 Rubie C....Schilling M.K. (J Transl Med 2010)
    42. Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis. (PubMed id 19006683)1, 9 Yoshida A....Kohno S. (Clin. Immunol. 2009)
    43. Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production. (PubMed id 19885605)1, 9 Kim K.Y....Yang Y. (Oncol. Rep. 2009)
    44. Macrophage-inflammatory protein-3alpha mediates epidermal growth factor receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin. (PubMed id 17548638)1, 9 Keates S....Keates A.C. (J. Immunol. 2007)
    45. BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially. (PubMed id 11877260)1, 9 Casamayor-PallejA M....Defrance T. (Blood 2002)
    46. Differentiated keratinocytes are responsible for TNF-alpha regulated production of macrophage inflammatory protein 3alpha/CCL20, a potent chemokine for Langerhans cells. (PubMed id 11532377)1, 9 Tohyama M....Hashimoto K. (J. Dermatol. Sci. 2001)
    47. Regulation of the psoriatic chemokine CCL20 by E3 ligases Trim32 and Piasy in keratinocytes. (PubMed id 20054338)1, 9 Liu Y....Kulesz-Martin M.F. (J. Invest. Dermatol. 2010)
    48. Enhanced expression and clinical significance of CC-chemokine MIP-3 alpha in hepatocellular carcinoma. (PubMed id 16764701)1, 9 Rubie C....Schilling M. (Scand. J. Immunol. 2006)
    49. Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases. (PubMed id 17075975)1, 9 Rubie C....Schilling M. (World J. Gastroenterol. 2006)
    50. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. (PubMed id 15679580)1, 9 Spiekstra S.W....Gibbs S. (Exp. Dermatol. 2005)
    51. Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells. (PubMed id 9294137)1, 9 Power C.A....Wells T.N. (J. Exp. Med. 1997)
    52. CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups. (PubMed id 19492413)1, 9 Lisignoli G....Facchini A. (J. Cell. Physiol. 2009)
    53. HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. (PubMed id 15972662)1, 9 Badr G....Richard Y. (J. Immunol. 2005)
    54. Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes. (PubMed id 14714554)1, 9 Pernet I....Viac J. (Exp. Dermatol. 2003)
    55. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. (PubMed id 11133838)1, 9 Nakayama T....Yoshie O. (Int. Immunol. 2001)
    56. Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6. (PubMed id 10438902)1, 9 Yang D....Oppenheim J.J. (J. Immunol. 1999)
    57. STRL22 is a receptor for the CC chemokine MIP-3alpha. (PubMed id 9223454)1, 9 Liao F....Farber J.M. (Biochem. Biophys. Res. Commun. 1997)
    58. Modulation of expression of innate immunity markers CXCL5/ENA-78 and CCL20/MIP3alpha by protease-activated receptors (PARs) in human gingival epithelial cells. (PubMed id 19567485)1, 9 Rohani M.G....Chung W.O. (Innate Immun 2010)
    59. CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells. (PubMed id 19233848)1, 9 Vongsa R.A....Dwinell M.B. (J. Biol. Chem. 2009)
    60. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. (PubMed id 19295614)1, 9 Harper E.G....Blauvelt A. (J. Invest. Dermatol. 2009)
    61. CC-chemokine ligand 20/macrophage inflammatory protein-3I+ and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions. (PubMed id 18703490)1, 9 Giuliani N....Rizzoli V. (Cancer Res. 2008)
    62. Chemokine redundancy in BOS pathogenesis. A possible role also for the CC chemokines: MIP3-beta, MIP3-alpha, MDC and their specific receptors. (PubMed id 18047937)1, 9 Meloni F....Fietta A.M. (Transpl. Immunol. 2008)
    63. Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue. (PubMed id 15671814)1, 9 Nakanishi T....Matsuo T. (J Endod 2005)
    64. Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function. (PubMed id 11994140)1, 9 Schmuth M....Heufler C. (Exp. Dermatol. 2002)
    65. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. (PubMed id 10521347)1, 9 Yang D....Oppenheim J.J. (Science 1999)
    66. CCL20 induces migration and proliferation on breast epithelial cells. (PubMed id 23460117)1 Marsigliante S....Muscella A. (J. Cell. Physiol. 2013)
    67. Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages. (PubMed id 23681234)1 Li Q....Simmet T. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)
    68. CCR6/CCL20 chemokine expression profile in distinct colorectal malignancies. (PubMed id 23790181)1 Frick V.O....Glanemann M. (Scand. J. Immunol. 2013)
    69. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    70. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin. (PubMed id 23717583)1 Li X....Wang S. (PLoS ONE 2013)
    71. Macrophage inflammatory protein-3 alpha (MIP-3a) is a novel serum prognostic marker in patients with colorectal cancer. (PubMed id 22926691)1 Iwata T....Kusunoki M. (J Surg Oncol 2013)
    72. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. (PubMed id 23011799)1 Miller M....Broide D.H. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    73. CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. (PubMed id 22796894)1 Oo Y.H....Adams D.H. (J. Hepatol. 2012)
    74. The role of chemokine CC ligand 20 in patients with liver cirrhosis and hepatocellular carcinoma. (PubMed id 22388957)1 Soliman H.H....Alm El-Din M.A. (Int. J. Biol. Markers 2012)
    75. MIP-3I+ expression in macrophages is NOD dependent. (PubMed id 22286692)1 Hausmann M....Rogler G. (Digestion 2012)
    76. miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. (PubMed id 22099878)1 Vicinus B....Schilling M.K. (Cancer Lett. 2012)
    77. Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunity. (PubMed id 21881590)1 Kennedy-Crispin M....Krueger J.G. (J. Invest. Dermatol. 2012)
    78. Antimicrobial responses of primary gingival cells to Porphyromonas gingivalis. (PubMed id 22860513)1 Dommisch H....Jepsen S. (J. Clin. Periodontol. 2012)
    79. Overexpression of CCL20 and its receptor CCR6 predicts poor clinical prognosis in human gliomas. (PubMed id 22926920)1 Wang L....Gao G. (Med. Oncol. 2012)
    80. Human papillomavirus type 8 interferes with a novel C/EBPI^-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration. (PubMed id 22911498)1 Sperling T....Smola S. (PLoS Pathog. 2012)
    81. MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20. (PubMed id 22001440)1 Yao T. and Lin Z. (Biochim. Biophys. Acta 2012)
    82. CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents. (PubMed id 22857950)1 Ouwehand K....Gibbs S. (Eur. J. Cell Biol. 2012)
    83. PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. (PubMed id 22533972)1 Nicholson I.C....Krumbiegel D. (Cell. Immunol. 2012)
    84. Brucella invasion of human intestinal epithelial cells elicits a weak proinflammatory response but a significant CCL20 secretion. (PubMed id 22553918)1 Ferrero M.C....Baldi P.C. (FEMS Immunol. Med. Microbiol. 2012)
    85. Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1I^-stimulated human gingival fibroblasts. (PubMed id 22019504)1 Hosokawa Y....Matsuo T. (Hum. Immunol. 2012)
    86. The serine protease plasmin triggers expression of the CC-chemokine ligand 20 in dendritic cells via Akt/NF-I_B-dependent pathways. (PubMed id 23118497)1 Li X....Simmet T. (amp 2012)
    87. Epigenetic regulation of human I^-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteria. (PubMed id 21248725)1 Yin L. and Chung W.O. (Mucosal Immunol 2011)
    88. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. (PubMed id 22048239)1 Miyagaki T....Sato S. (Clin. Cancer Res. 2011)
    89. CCL20 and I^-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions. (PubMed id 21178014)1 Ghannam S....PA"ne J. (J. Immunol. 2011)
    90. Fusobacterium nucleatum and human beta-defensins modulate the release of antimicrobial chemokine CCL20/macrophage inflammatory protein 3I+. (PubMed id 21911466)1 Ghosh S.K....Weinberg A. (Infect. Immun. 2011)
    91. Chemokine (C-C) motif ligand 20 is regulated by PGF(2I+)-F-prostanoid receptor signalling in endometrial adenocarcinoma and promotes cell proliferation. (PubMed id 20816914)1 Wallace A.E....Jabbour H.N. (Mol. Cell. Endocrinol. 2011)
    92. Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases. (PubMed id 21912453)1 Rubie C....Schilling M.K. (World J. Gastroenterol. 2011)
    93. CCL20 stimulates proinflammatory mediator synthesis in human fibroblast-like synoviocytes through a MAP kinase-dependent process with transcriptional and posttranscriptional control. (PubMed id 21724701)1 Alaaeddine N....Di Battista J.A. (J. Rheumatol. 2011)
    94. Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes. (PubMed id 21961038)1 GarcA-a-Arnandis I....Alcaraz M.J. (PLoS ONE 2011)
    95. Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. (PubMed id 21935436)1 Chen K.J....Zheng S.S. (PLoS ONE 2011)
    96. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. (PubMed id 21300824)1 Kim S....Nadel J.A. (J. Immunol. 2011)
    97. Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression. (PubMed id 21949768)1 Kirshberg S....Wald O. (PLoS ONE 2011)
    98. Exogenous HIV-1 Nef upsets the IFN-I^-induced impairment of human intestinal epithelial integrity. (PubMed id 21858117)1 Quaranta M.G....Viora M. (PLoS ONE 2011)
    99. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    100. Chemokine-mediated distribution of dendritic cell subsets in renal cell carcinoma. (PubMed id 20969772)1 Middel P....Radzun H.J. (BMC Cancer 2010)
    101. CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce anti-tumor immunity against gastric cancer ex vivo and in vivo. (PubMed id 20420712)1 He S....Zhang Y. (amp 2010)
    102. Response of corneal epithelial cells to Staphylococcus aureus. (PubMed id 21178448)1 Heimer S.R....Gilmore M. (Virulence 2010)
    103. CCR6 ligands inhibit HIV by inducing APOBEC3G. (PubMed id 20023216)1 Lafferty M.K....Garzino-Demo A. (Blood 2010)
    104. Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. (PubMed id 20595617)1 Ivison S.M....Steiner T.S. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010)
    105. Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer. (PubMed id 20439195)1 Raynaud C.M....Soria J.C. (Clin Lung Cancer 2010)
    106. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. (PubMed id 20511548)1 Ghannam S....Yssel H. (J. Immunol. 2010)
    107. Chemokine control of HIV-1 infection: beyond a binding competition. (PubMed id 20942936)1 Wu Y. (Retrovirology 2010)
    108. OX40 induces CCL20 expression in the context of antigen stimulation: an expanding role of co-stimulatory molecules in chemotaxis. (PubMed id 20400327)1 Zhong W....Rosenbaum J.T. (Cytokine 2010)
    109. Higher levels of CCL20 expression on peripheral blood mononuclear cells of chinese patients with inflammatory bowel disease. (PubMed id 20064082)1 He C....Li Y.Z. (Immunol. Invest. 2010)
    110. CCL20 is overexpressed in Mycobacterium tuberculosis-infected monocytes and inhibits the production of reactive oxygen species (ROS). (PubMed id 20819093)1 Rivero-Lezcano O.M....Diez-TascA^n C. (Clin. Exp. Immunol. 2010)
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    114. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)
    115. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. (PubMed id 19305396)1 Reboldi A....Sallusto F. (Nat. Immunol. 2009)
    116. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    117. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. (PubMed id 18757306)1 Medoff B.D....Xavier R.J. (Am. J. Respir. Cell Mol. Biol. 2009)
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    119. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    120. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. (PubMed id 18684866)1 Lamprecht B....Mathas S. (Blood 2008)
    121. Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection. (PubMed id 18576931)1 Hamill N....Hassan S.S. (J Perinat Med 2008)
    122. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
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    125. High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism. (PubMed id 17664181)1 Qi W....Pollock C.A. (Nephrol. Dial. Transplant. 2007)
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    129. Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3alpha)-induced dendritic cell migration. (PubMed id 15618437)1 Thorley A.J....Tetley T.D. (Am. J. Respir. Cell Mol. Biol. 2005)
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    131. Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. (PubMed id 12528183)1 Ambrosini E....Aloisi F. (Glia 2003)
    132. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. (PubMed id 12760962)1 Reibman J....Gordon T. (Am. J. Respir. Cell Mol. Biol. 2003)
    133. Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding. (PubMed id 11994436)1 Liao F....Farber J.M. (J. Immunol. 2002)
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    139. The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. (PubMed id 8076819)1 Matoba R....Matsubara K. (Gene 1994)
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    146. CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6. (PubMed id 19535263)9 Tanida S....Nakamura T. (Cytokine 2009)
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    148. CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines. (PubMed id 18582332)9 Takahashi K....Matsuo T. (Oral Microbiol. Immunol. 2008)
    149. Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritis. (PubMed id 16331752)9 Schlenk J....Beuscher H.U. (J. Rheumatol. 2005)
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    154. Serum amyloid A protein stimulates CCL20 production in rheumatoid synoviocytes. (PubMed id 19447772)9 Migita K....Ishibashi H. (Rheumatology (Oxford) 2009)
    155. Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells. (PubMed id 17924972)9 Lee S.K....Kim E.C. (Clin. Exp. Immunol. 2007)
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    158. Induction of macrophage-inflammatory protein-3alpha gene expression by TNF-dependent NF-kappaB activation. (PubMed id 12023359)9 Sugita S....Matsuyama T. (J. Immunol. 2002)
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    166. Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. (PubMed id 10225458)9 Kleeff J....Korc M. (Int. J. Cancer 1999)
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    175. Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts. (PubMed id 19910679)9 Hosokawa Y....Matsuo T. (Cell. Physiol. Biochem. 2009)
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    179. A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation. (PubMed id 9916893)9 Utans-Schneitz U....Lesslauer W. (J. Neuroimmunol. 1998)
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    181. The NF-kappaB, p38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes. (PubMed id 18492658)9 Dai X....Hashimoto K. (Int. Immunol. 2008)
    182. Ocular surface expression and in vitro activity of antimicrobial peptides. (PubMed id 17852183)9 Huang L.C....McDermott A.M. (Curr. Eye Res. 2007)
    183. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. (PubMed id 17272517)9 Katchar K....Keates A.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
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    185. Down-regulation of tristetraprolin expression results in enhanced IL-12 and MIP-2 production and reduced MIP-3alpha synthesis in activated macrophages. (PubMed id 17392586)9 Jalonen U....Moilanen E. (Mediators Inflamm. 2006)
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    187. Epigallocatechin-3-gallate impairs chemokine production in human colon epithelial cell lines. (PubMed id 16123309)9 Porath D....Schwager J. (J. Pharmacol. Exp. Ther. 2005)
    188. Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins. (PubMed id 15845500)9 Zughaier S.M....Stephens D.S. (Infect. Immun. 2005)
    189. Characterization of CCL20 secretion by human epithelial vaginal cells: involvement in Langerhans cell precursor attraction. (PubMed id 15831560)9 Cremel M....DelAczay O. (J. Leukoc. Biol. 2005)
    190. MIP-3alpha transfection into a rodent tumor cell line increases intratumoral dendritic cell infiltration but enhances (facilitates) tumor growth and decreases immunogenicity. (PubMed id 15470034)9 Bonnotte B....Vile R.G. (J. Immunol. 2004)
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    198. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. (PubMed id 16217013)9 Mahajan M.C....Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
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    240. Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. (PubMed id 19835594)9 Winder A.A....McCray P.B. (Respir. Res. 2009)
    241. TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner. (PubMed id 19434100)9 Tang W....Zheng D. (Cell Res. 2009)
    242. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. (PubMed id 19178937)9 Nathan A.T....Wills-Karp M. (J. Allergy Clin. Immunol. 2009)
    243. Liver transcriptome profiles associated with strain-specific Ehrlichia chaffeensis-induced hepatitis in SCID mice. (PubMed id 19001077)9 Miura K. and Rikihisa Y. (Infect. Immun. 2009)
    244. Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus. (PubMed id 19054079)9 Holland D.B....Holland K.T. (FEMS Microbiol. Lett. 2009)
    245. Interaction analyses of human monocytes co-cultured with different forms of Aspergillus fumigatus. (PubMed id 19074652)9 Loeffler J....Hebart H. (J. Med. Microbiol. 2009)
    246. Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium. (PubMed id 19713460)9 Tripathi A.K....Sullivan D.J. (Blood 2009)
    247. [Regulation of immune suppressive cytokines by TLR4 activation in colon cancer cells]. (PubMed id 19598032)9 Qi H.M....Wang J. (Zhonghua Wei Chang Wai Ke Za Zhi 2009)
    248. Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris. (PubMed id 19659772)9 Yoshizaki T....Harabuchi Y. (Clin. Exp. Immunol. 2009)
    249. Lactobacillus rhamnosus GG and Lactobacillus casei suppress Escherichia coli-induced chemokine expression in intestinal epithelial cells. (PubMed id 18716403)9 Toki S....Matsumoto K. (Int. Arch. Allergy Immunol. 2009)
    250. CXC and CC chemokines induced in human renal epithelial cells by inflammatory cytokines. (PubMed id 19594487)9 Thorburn E....Striz I. (APMIS 2009)
    251. Conditioning vaccination site with irradiated MIP-3alpha-transfected tumor cells enhances efficacy of dendritic cell-based cancer vaccine. (PubMed id 19342969)9 Shih N.Y....Liu K.J. (J. Immunother. 2009)
    252. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. (PubMed id 19359427)9 Ungaro R....Abreu M.T. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    253. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B. (PubMed id 19120450)9 Tang W....Zheng D. (FEBS J. 2009)
    254. Interleukin-1 regulates keratinocyte expression of T cell targeting chemokines through interleukin-1 receptor associated kinase-1 (IRAK1) dependent and independent pathways. (PubMed id 19166933)9 Sanmiguel J.C....Jensen L.E. (Cell. Signal. 2009)
    255. Development and function of TH17 cells in health and disease. (PubMed id 19410689)9 Louten Waal Malefyt R. (J. Allergy Clin. Immunol. 2009)
    256. Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (PubMed id 19716548)9 Wang Y....McArthur C. (Arch. Oral Biol. 2009)
    257. Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. (PubMed id 19428942)9 Ovrevik J....Refsnes M. (Toxicology 2009)
    258. The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion. (PubMed id 18188522)9 RAPdel F....Beuscher H.U. (Strahlenther Onkol 2008)
    259. Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. (PubMed id 18205922)9 Andreas K....Sittinger M. (amp 2008)
    260. Microarray analysis of amphotericin B-treated THP-1 monocytic cells identifies unique gene expression profiles among lipid and non-lipid drug formulations. (PubMed id 18606588)9 Turtinen L.W....Obr A. (J Chemother 2008)
    261. Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease. (PubMed id 18340639)9 Mitsuhashi M. and Targan S.R. (Inflamm. Bowel Dis. 2008)
    262. Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils. (PubMed id 18941247)9 Tamassia N....Cassatella M.A. (J. Immunol. 2008)
    263. CCR6 regulates the migration of inflammatory and regulatory T cells. (PubMed id 19050256)9 Yamazaki T....Dong C. (J. Immunol. 2008)
    264. Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage. (PubMed id 18592157)9 Matsumoto T....Ku Y. (J. Gastroenterol. 2008)
    265. Identification of cellular pathways of &quot;type 1,&quot; Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis. (PubMed id 18209089)9 Haider A.S....Krueger J.G. (J. Immunol. 2008)
    266. Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor. (PubMed id 18282300)9 Wang M....Ghannoum M.A. (BMC Microbiol. 2008)
    267. Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection. (PubMed id 19075290)9 Rao D.A....Pober J.S. (J. Exp. Med. 2008)
    268. Capture of an activated receptor complex from the surface of live cells by affinity receptor chromatography. (PubMed id 18601892)9 Jankowski A....Marshall J.G. (Anal. Biochem. 2008)
    269. Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. (PubMed id 18725395)9 Elia A.R....Giovarelli M. (J. Leukoc. Biol. 2008)
    270. Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway. (PubMed id 18315734)9 Vroling A.B....van Drunen C.M. (Allergy 2008)
    271. Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion. (PubMed id 18698005)9 Chizzolini C....Dayer J.M. (Blood 2008)
    272. Decreased cytokine and chemokine mRNA expression in bronchoalveolar lavage in asymptomatic smoking subjects. (PubMed id 18230951)9 Meuronen A....Laitinen A. ( international review of thoracic diseases 2008)
    273. Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium. (PubMed id 18523807)9 Sawa Y....Yoshida S. (Cell Tissue Res. 2008)
    274. Expression analysis of CCL27 and CCL28 mRNA in lesional and non-lesional skin of dogs with atopic dermatitis. (PubMed id 18250572)9 Maeda S....Kitagawa H. (J. Vet. Med. Sci. 2008)
    275. A pilot study to explore the usefulness of antibody array in childhood atopic dermatitis. (PubMed id 18507202)9 Hon K.L....Leung A.K. (J Natl Med Assoc 2008)
    276. Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypes. (PubMed id 18248761)9 Gobert A.P....Martin C. (Microbes Infect. 2008)
    277. Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor. (PubMed id 17928889)9 Travers J.B....Konger R.L. (J. Invest. Dermatol. 2008)
    278. Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. (PubMed id 18441283)9 Cho Y.S....Zhu Z. (Am. J. Respir. Cell Mol. Biol. 2008)
    279. S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes. (PubMed id 18044712)9 Nukui T....Huh N.H. (J. Cell. Biochem. 2008)
    280. Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. (PubMed id 18364398)9 Spadaro M....Giovarelli M. (FASEB J. 2008)
    281. [Gene expression profiles in human nasal polyps studied by DNA microarray]. (PubMed id 18727517)9 Liu B....Peng Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    282. Anthrax lethal toxin suppresses chemokine production in human neutrophil NB-4 cells. (PubMed id 18625197)9 Barson H.V....Rijpkema S. (Biochem. Biophys. Res. Commun. 2008)
    283. Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells. (PubMed id 18502823)9 Baumforth K.R....Murray P.G. (Am. J. Pathol. 2008)
    284. Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. (PubMed id 16891627)9 Fenton J.I....Hord N.G. (Carcinogenesis 2007)
    285. Dissecting genetic predisposition to inflammatory bowel disease: current progress and prospective application. (PubMed id 20477673)9 Annese V....Andriulli A. (Expert Rev Clin Immunol 2007)
    286. Shiga toxin produced by enterohemorrhagic Escherichia coli inhibits PI3K/NF-kappaB signaling pathway in globotriaosylceramide-3-negative human intestinal epithelial cells. (PubMed id 17548655)9 Gobert A.P....Martin C. (J. Immunol. 2007)
    287. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. (PubMed id 17712227)9 Son D.S....Khabele D. (amp 2007)
    288. Protease-activated receptor 2 mediates human beta-defensin 2 and CC chemokine ligand 20 mRNA expression in response to proteases secreted by Porphyromonas gingivalis. (PubMed id 17591792)9 Dommisch H....Dale B.A. (Infect. Immun. 2007)
    289. Dendritic cells accumulate in human fibrotic interstitial lung disease. (PubMed id 17717200)9 Marchal-SommAc J....Soler P. (Am. J. Respir. Crit. Care Med. 2007)
    290. Modulation of chemokines by staphylococcal superantigen in atopic dermatitis. (PubMed id 17369706)9 Homey B....Lauerma A. (Chem Immunol Allergy 2007)
    291. Hev b 6.01 and Hev b 5 induce pro-inflammatory cytokines and chemokines from peripheral blood mononuclear cells in latex allergy. (PubMed id 17210051)9 Lehto M....Alenius H. (Clin. Exp. Allergy 2007)
    292. Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1. (PubMed id 17498709)9 D'Cruz O.J. and Uckun F.M. (Fertil. Steril. 2007)
    293. Correlation of dendritic cell infiltration with active crypt inflammation in ulcerative colitis. (PubMed id 17178254)9 Watanabe S....Kimura O. (Clin. Immunol. 2007)
    294. CC-chemokine receptors in chronic obstructive pulmonary disease. (PubMed id 17692030)9 Bracke K.R....Brusselle G.G. (amp 2007)
    295. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. (PubMed id 17068485)9 Lebre Jong E.C. (J. Invest. Dermatol. 2007)
    296. Dual effect of butyrate on IL-1beta--mediated intestinal epithelial cell inflammatory response. (PubMed id 17417942)9 Blais M....Asselin C. (DNA Cell Biol. 2007)
    297. Malignant B cells from patients with primary central nervous system lymphoma express stromal cell-derived factor-1. (PubMed id 17369141)9 Smith J.R....Braziel R.M. (Am. J. Clin. Pathol. 2007)
    298. Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ). (PubMed id 18056395)9 Lakshmanan U. and Porter A.G. (J. Immunol. 2007)
    299. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. (PubMed id 17982039)9 Huang F....Wu R. (J. Immunol. 2007)
    300. Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus. (PubMed id 16552065)9 Cortez K.J....Walsh T.J. (Infect. Immun. 2006)
    301. Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. (PubMed id 17056573)9 Melikoglu M....Oliver S. (J. Immunol. 2006)
    302. Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism. (PubMed id 16118351)9 Middel P....Radzun H.J. (Gut 2006)
    303. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. (PubMed id 16982885)9 Hirahara K....Kupper T.S. (J. Immunol. 2006)
    304. Control of cytokine gene expression by PG101, a water-soluble extract prepared from Lentinus lepideus. (PubMed id 16344041)9 Choi J.J....Kim S. (Biochem. Biophys. Res. Commun. 2006)
    305. Tumor necrosis factor-alpha- and IL-4-independent development of Langerhans cell-like dendritic cells from M-CSF-conditioned precursors. (PubMed id 16417226)9 Barbaroux J.B....Mueller C.G. (J. Invest. Dermatol. 2006)
    306. Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. (PubMed id 16641550)9 Rubie C....Schilling M. (Tumour Biol. 2006)
    307. Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice. (PubMed id 16670374)9 Lin Y.L....Chiang B.L. (Mol. Pharmacol. 2006)
    308. Detection of up-regulated genes in thrombin-stimulated human umbilical vein endothelial cells. (PubMed id 16356540)9 Okada M....Shinohara T. (Thromb. Res. 2006)
    309. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. (PubMed id 16428770)9 Zhou Q. and Amar S. (Infect. Immun. 2006)
    310. Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses. (PubMed id 16540497)9 Hegmans J.P....Lambrecht B.N. (Eur. Respir. J. 2006)
    311. Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo. (PubMed id 17030562)9 Trifonova R.T....Fichorova R.N. (Antimicrob. Agents Chemother. 2006)
    312. The multifaceted roles of chemokines in malignancy. (PubMed id 17016763)9 Ben-Baruch A. (Cancer Metastasis Rev. 2006)
    313. Identification of specific gene expression profiles in fibroblasts derived from middle ear cholesteatoma. (PubMed id 16847181)9 Yoshikawa M....Moriyama H. (amp 2006)
    314. Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells. (PubMed id 16911361)9 Matsukura S....Adachi M. (Clin. Exp. Allergy 2006)
    315. Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy. (PubMed id 15860229)9 Ishii K....Seya T. (Immunol. Lett. 2005)
    316. Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions. (PubMed id 16106219)9 Ambrosini E....Coccia E.M. (J. Neuropathol. Exp. Neurol. 2005)
    317. Three-dimensional culture of melanoma cells profoundly affects gene expression profile: a high density oligonucleotide array study. (PubMed id 15744745)9 Ghosh S....Reschner A. (J. Cell. Physiol. 2005)
    318. TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. (PubMed id 16081850)9 Gottlieb A.B....Krueger J.G. (J. Immunol. 2005)
    319. CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease. (PubMed id 16045736)9 Hosokawa Y....Matsuo T. (Clin. Exp. Immunol. 2005)
    320. Patterns of protein expression in infectious meningitis: a cerebrospinal fluid protein array analysis. (PubMed id 15885808)9 Kastenbauer S....Koedel U. (J. Neuroimmunol. 2005)
    321. Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. (PubMed id 16316467)9 Ritter M....Seither P. (J Inflamm (Lond) 2005)
    322. Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissection. (PubMed id 16012957)9 Anderle P....Kraehenbuhl J.P. (Gastroenterology 2005)
    323. Cytokine interactions in mesenchymal stem cells from cord blood. (PubMed id 16377203)9 Liu C.H. and Hwang S.M. (Cytokine 2005)
    324. An optimized method for intensive screening of molecules that stimulate beta-defensin 2 or 3 (hBD2 or hBD3) expression in cultured normal human keratinocytes. (PubMed id 18492183)9 Pernet I....Perrier E. (Int J Cosmet Sci 2005)
    325. The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094)9 De Ceuninck F....Anract P. (Biochem. Biophys. Res. Commun. 2004)
    326. Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. (PubMed id 15009427)9 Niyonsaba F....Nagaoka I. (Immunology 2004)
    327. Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection. (PubMed id 15257040)9 Krukemeyer M.G....Krenn V. (Transplantation 2004)
    328. Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines. (PubMed id 15352210)9 Yabe T....Schwartz J.P. (J. Neurosci. Res. 2004)
    329. The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiation. (PubMed id 12829025)9 Cignetti A....Ghia P. (Exp. Hematol. 2003)
    330. Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin. (PubMed id 12925208)9 Kawase Y....Yoshino K. (J. Invest. Dermatol. 2003)
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    332. The CC chemokine CCL20 and its receptor CCR6. (PubMed id 12948524)9 Schutyser E....Van Damme J. (amp 2003)
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    336. CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas. (PubMed id 12514792)9 Rodig S.J....Dorfman D.M. (Hum. Pathol. 2002)
    337. Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells. (PubMed id 12147625)9 Corcione A....Pistoia V. (Int. Immunol. 2002)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6364 HGNC: 10619 AceView: CCL20 Ensembl:ENSG00000115009 euGenes: HUgn6364
    ECgene: CCL20 Kegg: 6364 H-InvDB: CCL20

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for CCL20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL20 gene:
    Search GeneIP for patents involving CCL20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
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     EMD Millipore genomic analysis products

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      GeneTex Antibodies for CCL20: CCL20 Antibodies
     Selected GeneTex Proteins for CCL20: MIP-3 alpha Recombinant Protein (Active) (GTX48366-PRO)
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