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Aliases for CCL2 Gene

Subcategory (RNA class) for CCL2 Gene

lncRNA

Aliases for CCL2 Gene

  • Chemokine (C-C Motif) Ligand 2 2 3
  • Monocyte Chemotactic And Activating Factor 2 3 4
  • Monocyte Chemotactic Protein 1 2 3 4
  • Monocyte Secretory Protein JE 2 3 4
  • SCYA2 3 4 6
  • MCAF 3 4 6
  • MCP1 3 4 6
  • Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je) 2 3
  • Monocyte Chemoattractant Protein-1 2 3
  • Monocyte Chemoattractant Protein 1 3 4
  • Small-Inducible Cytokine A2 3 4
  • MCP-1 3 4
  • HC11 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys) 2
  • Homologous To Mouse Sig-Je 2
  • C-C Motif Chemokine 2 3
  • Member 2 2
  • HSMCR30 3
  • GDCF-2 3
  • SMC-CF 3

External Ids for CCL2 Gene

ORGUL Members for CCL2 Gene

Previous HGNC Symbols for CCL2 Gene

  • SCYA2

Previous GeneCards Identifiers for CCL2 Gene

  • GC17P032352
  • GC17P034621
  • GC17P032727
  • GC17P029606
  • GC17P032582
  • GC17P028767

Summaries for CCL2 Gene

Entrez Gene Summary for CCL2 Gene

  • This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL2 Gene

CCL2 (Chemokine (C-C Motif) Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include tuberculosis and hiv-1. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and heparin binding. An important paralog of this gene is CCL8.

UniProtKB/Swiss-Prot for CCL2 Gene

  • Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis

Gene Wiki entry for CCL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL2 Gene

Genomics for CCL2 Gene

Regulatory Elements for CCL2 Gene

Genomic Location for CCL2 Gene

Start:
34,255,218 bp from pter
End:
34,257,203 bp from pter
Size:
1,986 bases
Orientation:
Plus strand

Genomic View for CCL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL2 Gene

Proteins for CCL2 Gene

  • Protein details for CCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13500-CCL2_HUMAN
    Recommended name:
    C-C motif chemokine 2
    Protein Accession:
    P13500
    Secondary Accessions:
    • B2R4V3
    • Q9UDF3

    Protein attributes for CCL2 Gene

    Size:
    99 amino acids
    Molecular mass:
    11025 Da
    Quaternary structure:
    • Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.

    Three dimensional structures from OCA and Proteopedia for CCL2 Gene

neXtProt entry for CCL2 Gene

Proteomics data for CCL2 Gene at MOPED

Post-translational modifications for CCL2 Gene

  • Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant
  • Glycosylation at Asn37

Other Protein References for CCL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCL2 (CCL2)

Protein Products

No data available for DME Specific Peptides for CCL2 Gene

Domains for CCL2 Gene

Gene Families for CCL2 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL2 Gene

Suggested Antigen Peptide Sequences for CCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13500

UniProtKB/Swiss-Prot:

CCL2_HUMAN :
  • P13500
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL2: view

Function for CCL2 Gene

Molecular function for CCL2 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis
UniProtKB/Swiss-Prot Induction: Up-regulated upon hypertonic conditions.

Gene Ontology (GO) - Molecular Function for CCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding --
GO:0004672 protein kinase activity TAS 9973507
GO:0005102 receptor binding TAS 10542238
GO:0005515 protein binding --
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL2: view
genes like me logo Genes that share phenotypes with CCL2: view

Animal Models for CCL2 Gene

MGI Knock Outs for CCL2:

Animal Model Products

CRISPR Products

miRNA for CCL2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCL2 Gene

Localization for CCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL2 Gene COMPARTMENTS Subcellular localization image for CCL2 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
peroxisome 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with CCL2: view

Pathways for CCL2 Gene

genes like me logo Genes that share pathways with CCL2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001525 angiogenesis TAS 18334747
GO:0001666 response to hypoxia IEA --
GO:0001912 positive regulation of leukocyte mediated cytotoxicity IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with CCL2: view

Compounds for CCL2 Gene

(3) HMDB Compounds for CCL2 Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5
Danazol
  • (17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
17230-88-5
Simvastatin
  • (+)-Simvastatin
79902-63-9

(2) Drugbank Compounds for CCL2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Danazol
17230-88-5 target inhibitor
Mimosine
  • L-Mimosine
500-44-7 target inhibitor

(150) Novoseek inferred chemical compound relationships for CCL2 Gene

Compound -log(P) Hits PubMed IDs
rantes 96 390
mcp 1 85 53
ccl3 83.4 109
groalpha 79.1 50
tarc 71 31
genes like me logo Genes that share compounds with CCL2: view

Transcripts for CCL2 Gene

mRNA/cDNA for CCL2 Gene

Unigene Clusters for CCL2 Gene

Chemokine (C-C motif) ligand 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CCL2 Gene

GeneLoc Exon Structure for
CCL2
ECgene alternative splicing isoforms for
CCL2

Expression for CCL2 Gene

mRNA expression in normal human tissues for CCL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCL2 Gene

SOURCE GeneReport for Unigene cluster for CCL2 Gene Hs.303649

genes like me logo Genes that share expressions with CCL2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCL2 Gene

Orthologs for CCL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL2 35
  • 98.65 (n)
  • 100 (a)
CCL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL2 35
  • 81.29 (n)
  • 72.45 (a)
CCL2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL2 35
  • 84.37 (n)
  • 79.17 (a)
CCL2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl12 35
  • 74.49 (n)
  • 66.67 (a)
Ccl2 16
Ccl2 36
  • 36 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ccl12 35
  • 74.36 (n)
  • 62.82 (a)
Species with no ortholog for CCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL2 Gene

ENSEMBL:
Gene Tree for CCL2 (if available)
TreeFam:
Gene Tree for CCL2 (if available)

Paralogs for CCL2 Gene

Paralogs for CCL2 Gene

Selected SIMAP similar genes for CCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL2: view

Variants for CCL2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL2 Gene

P13500-CCL2_HUMAN
Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]

Sequence variations from dbSNP and Humsavar for CCL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4586 -- 34,256,250(+) TGCTG(C/T)TATAA synonymous-codon, reference
rs13900 -- 34,256,892(+) ACACC(C/T)TGTTT utr-variant-3-prime
rs1014542 -- 34,254,259(+) AGGAG(A/C)ATAGC upstream-variant-2KB
rs2190971 -- 34,257,416(-) AAGAC(G/T)GGAAG downstream-variant-500B
rs2190972 -- 34,254,373(-) GACAG(A/C)TAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL2 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Relevant External Links for CCL2 Gene

HapMap Linkage Disequilibrium report
CCL2
Human Gene Mutation Database (HGMD)
CCL2

Disorders for CCL2 Gene

(3) OMIM Diseases for CCL2 Gene (158105)

(96) Novoseek inferred disease relationships for CCL2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 86.3 156
necrosis 82.7 152
atherosclerosis 79.6 138
tumors 67.6 244
atherosclerotic plaque 65.6 24

Relevant External Links for CCL2

Genetic Association Database (GAD)
CCL2
Human Genome Epidemiology (HuGE) Navigator
CCL2
genes like me logo Genes that share disorders with CCL2: view

No data available for UniProtKB/Swiss-Prot for CCL2 Gene

Publications for CCL2 Gene

  1. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PMID: 16352737) Flores-Villanueva P.O. … Granados J. (J. Exp. Med. 2005) 3 4 23 48
  2. Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy. (PMID: 16362156) Mori H. … Gejyo F. (Clin. Exp. Nephrol. 2005) 3 23 48
  3. Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis. (PMID: 16524739) Nadif R. … Kleeberger S.R. (Cytokine 2006) 3 23 48
  4. Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism. (PMID: 16050950) Zietz B. … SchAoffler A. (Diabetes Obes Metab 2005) 3 23 48
  5. Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. (PMID: 16280979) Wegscheider B.J. … El-Shabrawi Y. (Mol. Vis. 2005) 3 23 48

Products for CCL2 Gene

  • Addgene plasmids for CCL2

Sources for CCL2 Gene

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