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CCL2 Gene

protein-coding   GIFtS: 70
GCID: GC17P032582

Chemokine (C-C Motif) Ligand 2

(Previous names: small inducible cytokine A2 (monocyte chemotactic protein...)
(Previous symbol: SCYA2)
  See CCL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 21 2     HC112 3
SCYA21 2 3 5     MCP-12 3
Monocyte Chemotactic And Activating Factor1 2 3     Homologous To Mouse Sig-Je1
Monocyte Chemotactic Protein 11 2 3     Member 21
Monocyte Secretory Protein JE1 2 3     Small Inducible Cytokine Subfamily A (Cys-Cys)1
MCAF2 3 5     GDCF-22
MCP12 3 5     HSMCR302
Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To
Mouse Sig-Je)1 2
     SMC-CF2
Monocyte Chemoattractant Protein-11 2     C-C Motif Chemokine 22
Monocyte Chemoattractant Protein 12 3     Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22
Small-Inducible Cytokine A22 3     

External Ids:    HGNC: 106181   Entrez Gene: 63472   Ensembl: ENSG000001086917   OMIM: 1581055   UniProtKB: P135003   
ORGUL members:         

Export aliases for CCL2 gene to outside databases

Previous GC identifers: GC17P032352 GC17P034621 GC17P032727 GC17P029606 GC17P028767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL2 Gene:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine
is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays
chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated
in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and
atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (provided by RefSeq, Jul 2013)

GeneCards Summary for CCL2 Gene:
CCL2 (chemokine (C-C motif) ligand 2) is a protein-coding gene. Diseases associated with CCL2 include coronary artery disease, modifier of, and spina bifida. GO annotations related to this gene include heparin binding and receptor binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500
Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments
monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic
infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of
monocytes into the arterial wall during the disease process of atherosclerosis

Gene Wiki entry for CCL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL2 gene promoter:
         c-Fos   STAT1   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL2 promoter sequence
   Search Chromatin IP Primers for CCL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q21.1

CCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032582:  view genomic region     (about GC identifiers)

Start:
32,582,296 bp from pter      End:
32,584,222 bp from pter
Size:
1,927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500 (See protein sequence)
Recommended Name: C-C motif chemokine 2 precursor  
Size: 99 amino acids; 11025 Da
Subunit: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by
glycosaminoglycan (GAG) side chains of proteoglycans
Selected PDB 3D structures from and Proteopedia for CCL2 (see all 10):
1DOK (3D)        1DOL (3D)        1DOM (3D)        1DON (3D)        1MCA (3D)        1ML0 (3D)    
Secondary accessions: B2R4V3 Q9UDF3

Explore the universe of human proteins at neXtProt for CCL2: NX_P13500

Explore proteomics data for CCL2 at MOPED

Post-translational modifications: 

  • Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue
    converts it from an activator of basophil to an eosinophil chemoattractant1
  • Glycosylation2 at Asn37

  • See CCL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002973.1  
    ENSEMBL proteins: 
     ENSP00000462156   ENSP00000225831  
    Reactome Protein details: P13500

    CCL2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCL2 Protein
    R&D Systems Recombinant & Natural Proteins for CCL2 (CCL2/JE/MCP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL2
    OriGene Protein Over-expression Lysate for CCL2
    OriGene MassSpec for CCL2
    OriGene Custom Protein Services for CCL2
    GenScript Purified and Recombinant Proteins for CCL2
    Novus Biologicals CCL2 Proteins
    Novus Biologicals CCL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for CCL2
    ProSpec Recombinant Protein for CCL2
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for CCL2:  
                        Human CCL2 (MCP-1) Recombinant Protein 5 ug

    CCL2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL2
    R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
    OriGene Antibodies for CCL2
    OriGene Custom Antibody Services for CCL2
    Novus Biologicals CCL2 Antibodies
    Abcam antibodies for CCL2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CCL2
    LSBio Antibodies in human, mouse, rat for CCL2

    CCL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL2
    R&D Systems Flow Cytometry Kits for CCL2 (CCL2/JE/MCP-1)         (see all)
    GenScript Custom Assay Services for CCL2
    Enzo Life Sciences assays for CCL2
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CCL2: (see all 6
                        Human CCL2 (MCP-1) ELISA Ready-SET-Go! 2 x 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P13500

    ProtoNet protein and cluster: P13500

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL2_HUMAN, P13500
    Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments
    monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic
    infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of
    monocytes into the arterial wall during the disease process of atherosclerosis
    Induction: Up-regulated upon hypertonic conditions

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding ----
    GO:0004672protein kinase activity TAS9973507
    GO:0005102receptor binding TAS10542238
    GO:0005515protein binding ----
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CCL2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCL2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ccl2) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with CCL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCL2: Ccl2tm1Lex Ccl2tm1Rol Ccl2tm1.1Tyos

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL2:
    hsa-mir-26b-5p (MIRT030277), hsa-mir-155-5p (MIRT021047), hsa-mir-1 (MIRT024058), hsa-mir-124-3p (MIRT004284), hsa-mir-24-3p (MIRT030558)

    Block miRNA regulation of human, mouse, rat CCL2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCL2:
    hsa-miR-577 hsa-miR-323-3p hsa-miR-3910 hsa-miR-374b hsa-miR-3143 hsa-miR-374a hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCCL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL2
    Predesigned siRNA for gene silencing in human, mouse, rat CCL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL2

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL2 (see all 6)
    OriGene ORF clones in mouse, rat for CCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL2 (NM_002982)
    Sino Biological Human cDNA Clone for CCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL2
    Addgene plasmids for CCL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11041) for CCL2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL2_HUMAN, P13500: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    peroxisome2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with CCL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL2 About   (see all 31)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40


    Find genes that share SuperPaths with CCL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CCL2
        A-beta Uptake & Degradation
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL2 (see all 30)
        MSP-RON Signaling
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions

    3 GeneGo (Thomson Reuters) Pathways for CCL2
        Development VEGF signaling via VEGFR2 - generic cascades
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response Oncostatin M signaling via MAPK in human cells

    Selected BioSystems Pathways for CCL2 (see all 6)
        Oncostatin M Signaling Pathway
    Spinal Cord Injury
    Selenium Pathway
    TWEAK Signaling Pathway
    IL23-mediated signaling events


    2 Reactome Pathways for CCL2
        Chemokine receptors bind chemokines
    ATF4 activates genes


    Selected Kegg Pathways  (Kegg details for CCL2) (see all 9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway
    Chagas disease (American trypanosomiasis)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL2 (see all 29): 
              HIV Host Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCL2 (P135003 ENSP000002258314) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    CCR3P516773, ENSP000003500034I2D: score=2 STRING: ENSP00000350003
    CCL11P516713, ENSP000003022344I2D: score=1 STRING: ENSP00000302234
    CCR10P460923, ENSP000003325044I2D: score=1 STRING: ENSP00000332504
    MMP1P039563, ENSP000003227884I2D: score=1 STRING: ENSP00000322788
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 70):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0001525angiogenesis TAS18334747
    GO:0001666response to hypoxia IEA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0002548monocyte chemotaxis IDA12207323

    Find genes that share ontologies with CCL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL2

    3 HMDB Compounds for CCL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Danazol(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)17230-88-5--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    2 DrugBank Compounds for CCL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Danazol-- 17230-88-5targetinhibitor11216879 11056242
    MimosineL-Mimosine (see all 6)500-44-7targetinhibitor11936838 15698514

    Selected Novoseek inferred chemical compound relationships for CCL2 gene (see all 150)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 96 1626 11750041 (8), 8616572 (7), 15631778 (7), 17353158 (7) (see all 99)
    mcp 1 85 69 20497022 (5), 16091493 (4), 18045859 (3), 20032813 (3) (see all 34)
    ccl3 83.4 145 20047691 (5), 16105698 (5), 18070228 (4), 18270300 (4) (see all 81)
    groalpha 79.1 60 10540194 (4), 16213701 (4), 16869002 (4), 15044249 (3) (see all 30)
    tarc 71 41 12911508 (2), 19536139 (2), 14630994 (2), 11533168 (2) (see all 24)
    grogamma 70.8 8 15832427 (2), 10467937 (2), 15972545 (1), 11808935 (1) (see all 5)
    vegf 66.3 386 14574083 (8), 15627719 (7), 16273763 (6), 18385799 (6) (see all 99)
    mip 1alpha 64.7 9 20205697 (2), 16211583 (1), 15932509 (1), 19506561 (1) (see all 8)
    grobeta 62.7 6 15832427 (2), 12556377 (1), 11808935 (1), 17442617 (1)
    bindarit 56.9 13 18827968 (4), 10477401 (2), 17460736 (1), 9507220 (1)



    Find genes that share compounds with CCL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CCL2 gene: 
    NM_002982.3  

    Unigene Cluster for CCL2:

    Chemokine (C-C motif) ligand 2
    Hs.303649  [show with all ESTs]
    Unigene Representative Sequence: BU570769
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580907 ENST00000225831(uc002hhy.3) ENST00000582017
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCL2:
    hsa-miR-577 hsa-miR-323-3p hsa-miR-3910 hsa-miR-374b hsa-miR-3143 hsa-miR-374a hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidCCL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCL2
    Predesigned siRNA for gene silencing in human, mouse, rat CCL2
    Clone
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    OriGene clones in human, mouse for CCL2 (see all 6)
    OriGene ORF clones in mouse, rat for CCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL2 (NM_002982)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL2
    Addgene plasmids for CCL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL2
      QuantiTect SYBR Green Assays in human, mouse, rat CCL2
      QuantiFast Probe-based Assays in human, mouse, rat CCL2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11041) for CCL2 

    Additional mRNA sequence: 

    AK311308.1 AK311960.1 BC009716.1 BT007329.1 M24545.1 M28226.1 S69738.1 S71513.1 
    X14768.1 

    5 DOTS entries:

    DT.217745  DT.100795505  DT.100795508  DT.100795510  DT.91845238 

    Selected AceView cDNA sequences (see all 231):

    CK902136 R80529 AI097531 BU192217 AL697816 BE671641 T29155 BE858648 
    AW849229 AI692798 BC009716 BM708613 AA047099 X14768 AI927247 NM_002982 
    BI793067 BQ224954 AI075862 BF850412 AI817756 CK902135 S71513 BM704915 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CCL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTAGTGT
    CCL2 Expression
    About this image


    CCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells (family)
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             PureStem E15, Meso-prx/latp Progenitor
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    CCL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.303649
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL2 (see all 29): 
              HIV Host Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat

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    OriGene qSTAR qPCR primer pairs in human, mouse for CCL2
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    QuantiTect SYBR Green Assays in human, mouse, rat CCL2
    QuantiFast Probe-based Assays in human, mouse, rat CCL2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl25
    Ccl121
    chemokine (C-C motif) ligand 25
    chemokine (C-C motif) ligand 121
    74.49(n)1
    66.67(a)1
      11 (49.82 cM)5
    202931  NM_011331.21  NP_035461.21 
     820355715 


    ENSEMBL Gene Tree for CCL2 (if available)
    TreeFam Gene Tree for CCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL2 gene
    CCL112  CCL132  CCL72  CCL82  CCL242  
    Selected SIMAP similar genes for CCL2 using alignment to 2 protein entries:     CCL2_HUMAN (see all proteins) (see all similar genes):
    MCP1    CCL11    CCL8    CCL7    MCP-3    CCL13
    CCL3L1    CCL3L3    CCL4    CCL4L2    LOC728835    CCL4L1
    CCL3    CX3CL1    CCL18    CCL26    CCL14    CCL1

    Find genes that share paralogs with CCL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CCL2_HUMAN, P13500: Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]


    Selected SNPs for CCL2 (see all 100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133067501,2
    C--28768301(+) TTTAACAGCTCCT
    CCTTCT
    /-
    CTCTG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs39178871,2
    C,F--28768302(+) TTAACAGCTCCTC
    CTTCTC
    /-
    TCTGT
    1 -- int13Minor allele frequency- -:0.36NS NA 136
    rs37603991,2
    C,F,H--32642751(-) TGGAGT/CGGCCA 1 -- us2k118Minor allele frequency- C:0.05NS EA NA 1726
    rs1869603791,2
    --32642814(+) CAAGTC/TTAGTC 1 -- us2k10--------
    rs39178861,2
    C,F--32642835(+) GAGATT/ACTGGA 1 -- us2k15Minor allele frequency- A:0.03NS NA WA 216
    rs1468606061,2
    C--32643006(+) CTCAAC/TAATGC 1 -- us2k10--------
    rs30913321,2
    C,F--32643013(+) ATGCCA/TTTACT 1 -- us2k114Minor allele frequency- T:0.10NA NS WA 918
    rs1393459651,2
    --32643089(+) GAAAAG/TTGTTT 1 -- us2k10--------
    rs1928506641,2
    --32643286(+) CTATCA/GTATTT 1 -- us2k10--------
    rs1500700221,2
    --32643345(+) TATCAA/GTGTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL2 (32582296 - 32584222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CCL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 158105   
    OMIM disorders: 609423  182940  607948  
    Selected diseases for CCL2 (see all 45):    
    About MalaCards
    coronary artery disease, modifier of    spina bifida    proliferative glomerulonephritis    scleritis
    hiv-1    pneumoconiosis    xanthogranulomatous pyelonephritis    rapidly progressive glomerulonephritis
    encephalitis    peritonitis    psoriasis    temporal arteritis
    idiopathic pulmonary alveolar proteinosis    dengue shock syndrome    relapsing polychondritis    mesangial proliferative glomerulonephritis
    lupus nephritis    ureteral disease    sympathetic ophthalmia    diabetic angiopathy

    18 diseases from the University of Copenhagen DISEASES database for CCL2:
    Atherosclerosis     Kidney disease     Arthritis     Diabetes mellitus
    Heart disease     Hypersensitivity reaction type II disease     Asthma     Cancer
    Eye disease     Multiple sclerosis     Connective tissue disease     Hypertension
    Pneumonia     Interstitial lung disease     Endometriosis     Ureteral disease
    Encephalitis     Peritonitis

    Find genes that share disorders with CCL2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 86.3 568 15104334 (4), 11739289 (4), 17977946 (4), 7891256 (3) (see all 99)
    necrosis 82.7 1069 15626982 (5), 7635182 (3), 15223398 (3), 16407046 (3) (see all 99)
    atherosclerosis 79.6 284 17521622 (5), 15894320 (4), 15519012 (4), 12578870 (3) (see all 99)
    tumors 67.6 1198 15883814 (5), 9111518 (5), 16278381 (5), 15626982 (5) (see all 99)
    atherosclerotic plaque 65.6 35 14739122 (2), 16934270 (1), 19566488 (1), 19656094 (1) (see all 23)
    bronchoalveolar lavage fluid 56.3 42 8890891 (3), 10515417 (2), 10489845 (2), 8616572 (1) (see all 30)
    rheumatoid arthritis 56.3 60 16740681 (3), 12826377 (2), 11411959 (2), 14626631 (2) (see all 40)
    lupus nephritis 53.8 45 11780369 (7), 8558841 (6), 16334978 (4), 15119544 (2) (see all 17)
    cardiovascular diseases 53.7 39 19566488 (3), 15030267 (3), 15627719 (2), 11919402 (1) (see all 20)
    insulin resistance 53.6 86 18762729 (5), 15349727 (4), 19361458 (4), 15063799 (3) (see all 33)

    Genetic Association Database (GAD): CCL2
    Human Genome Epidemiology (HuGE) Navigator: CCL2 (260 documents)

    Export disorders for CCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL2 gene, integrated from 10 sources (see all 3777):
    (articles sorted by number of sources associating them with CCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PubMed id 16352737)1, 2, 4, 9 Flores-Villanueva P.O.... Granados J. (J. Exp. Med. 2005)
    2. Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness. (PubMed id 14620921)1, 4, 9 Tabara Y....Miki T. (Hypertens. Res. 2003)
    3. The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis. (PubMed id 18069114)1, 4, 9 Kim J.Y....Kim J.G. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008)
    4. Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes. (PubMed id 18762729)1, 4, 9 Kouyama K....Kasuga M. (Kobe J Med Sci 2007)
    5. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. (PubMed id 16116069)1, 4, 9 McDermott D.H....Benjamin E.J. (Circulation 2005)
    6. MCP-1 gene (SCYA2) and schizophrenia: a case-control association study. (PubMed id 15389752)1, 4, 9 Mundo E....Gennarelli M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    7. Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians. (PubMed id 15288699)1, 4, 9 Pola R....Pola P. (Exp. Gerontol. 2004)
    8. MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. (PubMed id 20497022)1, 4, 9 Liu S.F....Lin M.C. (Exp. Lung Res. 2010)
    9. MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease. (PubMed id 17728497)1, 4, 9 Joo K.W....Ahn C. (J. Korean Med. Sci. 2007)
    10. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6347 HGNC: 10618 AceView: CCL2 Ensembl:ENSG00000108691 euGenes: HUgn6347
    ECgene: CCL2 Kegg: 6347 H-InvDB: CCL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL2
    SeattleSNPshttp://pga.gs.washington.edu/data/scya2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL2 gene:
    Search GeneIP for patents involving CCL2

    Licensable Technologies for CCL2 gene:
    Weizmann Institute:CCL2 for the Treatment of Inflammation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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