Aliases for CCL2 Gene
Subcategory (RNA class) for CCL2 Gene
lncRNA
Aliases for CCL2 Gene
- C-C Motif Chemokine Ligand 2 2 3 5
- Monocyte Chemotactic And Activating Factor 2 3 4
- Monocyte Secretory Protein JE 2 3 4
- Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je) 2 3
- Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2 2 3
- Monocyte Chemoattractant Protein-1 2 3
- Chemokine (C-C Motif) Ligand 2 2 3
- Monocyte Chemotactic Protein 1 3 4
- Small-Inducible Cytokine A2 3 4
- SCYA2 3 4
- MCP-1 3 4
External Ids for CCL2 Gene
- HGNC: 10618
- Entrez Gene: 6347
- Ensembl: ENSG00000108691
- OMIM: 158105
- UniProtKB: P13500
ORGUL Members for CCL2 Gene
Previous HGNC Symbols for CCL2 Gene
- SCYA2
Previous GeneCards Identifiers for CCL2 Gene
- GC17P032352
- GC17P034621
- GC17P032727
- GC17P029606
- GC17P032582
- GC17P028767
Summaries for CCL2 Gene
-
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
GeneCards Summary for CCL2 Gene
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included and Neural Tube Defects. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and PEDF Induced Signaling. GO annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.
UniProtKB/Swiss-Prot for CCL2 Gene
-
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL2 Gene
Genomics for CCL2 Gene
Regulatory Elements for CCL2 Gene
Enhancers for CCL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G034387 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 44.3 | +132.2 | 132239 | 0.9 | PKNOX1 ZNF146 ATF1 FOSL1 ZNF316 SCRT2 NFE2 FOS CREM SMARCE1 | CCL1 CCL2 CCL7 CCL8 GC17M034364 GC17P034446 |
| GH17G034386 | 0.8 | FANTOM5 dbSUPER | 43.8 | +131.5 | 131516 | 0.2 | ZNF316 ATF3 ZKSCAN8 ZBTB11 | CCL1 CCL2 GC17M034364 GC17P034446 |
| GH17G034233 | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 17.8 | -19.8 | -19805 | 3.2 | MAX REST ZIC2 RAD21 NR2F2 YY1 FOXA1 JUND ATF3 GLIS1 | CCL2 CCL1 CCL7 CCL8 GC17M034278 GC17P034213 |
| GH17G034412 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 13.9 | +158.0 | 157952 | 1.8 | PKNOX1 NFRKB TCF12 GATA2 FOS ZNF280D CAVIN1 ELF4 ELF1 ZNF592 | CCL2 CCL7 C17orf102 TMEM132E ASIC2 CCL1 CCL8 GC17P034446 GC17M034364 |
| GH17G034400 | 0.6 | FANTOM5 dbSUPER | 29.6 | +145.7 | 145676 | 0.2 | ZNF263 | CCL1 CCL2 GC17M034364 GC17P034446 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCL2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCL2 gene promoter:
Regulatory Element Products
Genomic Location for CCL2 Gene
- Chromosome:
- 17
- Start:
- 34,255,218 bp from pter
- End:
- 34,257,203 bp from pter
- Size:
- 1,986 bases
- Orientation:
- Plus strand
Genomic View for CCL2 Gene
Genes around CCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
CCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL2 Gene
Proteins for CCL2 Gene
-
Protein details for CCL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13500-CCL2_HUMAN
- Recommended name:
- C-C motif chemokine 2
- Protein Accession:
- P13500
- B2R4V3
- Q9UDF3
Protein attributes for CCL2 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11025 Da
- Quaternary structure:
-
- Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
Protein Expression for CCL2 Gene
Post-translational modifications for CCL2 Gene
- Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
- Glycosylation at Asn37
Other Protein References for CCL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CCL2
- R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
- Cell Signaling Technology (CST) Antibodies for CCL2 (CCL2)
-
Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
- AM06749PU-N
- AM26297PU-N
- AM31289AF-N
- AM31290AF-N
- AP09164PU-N
- AP09164PU-S
- AP26385PU-N
- DM2030
- DM2031
- DM2032
- DM2033
- DM2034
- DM2034B
- DM2034HRP
- PM1006A
- PP020B1
- PP020B2
- PP020P1
- PP020P2
- PP037B1
- PP037B2
- PP037P1
- PP037P2
- PP1044B1
- PP1044B2
- PP1044P1
- PP1044P2
- SM2289P
- TA319166
- TA319701
- TA320225
- TA320226
- TA320227
- TA321546
- TA321547
- TA324861
- TA328374
- TA328375
- TA336723
- TA336724
- TA336914
- TA352601
- TA352602
- TA590148
- TA805016
- CF805016
- TA600025
- TA700025
- Novus Biologicals Antibodies for CCL2
-
Cloud-Clone Corp. Antibodies for CCL2
- Invitrogen Antibodies for CCL2
- antibodies-online Antibodies for CCL2: See all 493
- GeneTex CCL2 antibody for CCL2
-
Custom Antibody ServicesProSci Antibodies for CCL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
Protein Products
- EMD Millipore Purified and/or Recombinant CCL2 Protein
- R&D Systems Proteins and Enzymes for CCL2 (CCL2/JE/MCP-1)
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
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- Sino Biological Recombinant Proteins for CCL2
- Sino Biological Cell Lysates for CCL2
- ProSpec Recombinant Proteins for CCL2
-
Cloud-Clone Corp. Proteins for CCL2
- eBioscience Human CCL2 (MCP-1) Recombinant Protein 5 ug for CCL2
- antibodies-online Proteins for CCL2: See all 164
- Search antibodies-online for peptides
- GeneTex Proteins for CCL2
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL2 (CCL2/JE/MCP-1)
- Enzo Life Sciences assays for CCL2
- antibodies-online Kits for CCL2: See all 182
No data available for DME Specific Peptides for CCL2 Gene
Domains & Families for CCL2 Gene
Gene Families for CCL2 Gene
Protein Domains for CCL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13500- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL2 Gene
Molecular function for CCL2 Gene
- UniProtKB/Swiss-Prot Function:
- Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated upon hypertonic conditions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IEA | -- |
| GO:0004672 | protein kinase activity | TAS | 9973507 |
| GO:0005102 | receptor binding | TAS | 10542238 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0008009 | chemokine activity | IBA,TAS | -- |
Phenotypes for CCL2 Gene
- MGI mutant phenotypes for CCL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCL2:
Animal Model Products
-
Taconic Biosciences Mouse Models for CCL2
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL2 gene
- Search ViGene Biosciences for CCL2
CRISPR Products
-
OriGene CRISPR knockouts for CCL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- GenScript: Design CRISPR guide RNA sequences for CCL2
miRNA for CCL2 Gene
- miRTarBase miRNAs that target CCL2
miRNA Products
- Search ViGene Biosciences for CCL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL2 gene
Clone Products
- Sino Biological Human cDNA Clone for CCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCL2
Cell Line Products
-
Horizon Cell Lines for CCL2
-
ViGene Biosciences adenoviral particle packaged cDNA for CCL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL2 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11041 ) for CCL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL2 Gene
Localization for CCL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,IBA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for CCL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | ERK Signaling |
.61
|
|
| 5 | Folate Metabolism | ||
Pathways by source for CCL2 Gene
1 GeneTex pathway for CCL2 Gene
2 Cell Signaling Technology pathways for CCL2 Gene
13 BioSystems pathways for CCL2 Gene
9 Reactome pathways for CCL2 Gene
12 KEGG pathways for CCL2 Gene
3 GeneGo (Thomson Reuters) pathways for CCL2 Gene
4 R&D Systems pathways for CCL2 Gene
30 Qiagen pathways for CCL2 Gene
Interacting Proteins for CCL2 Gene
Selected Interacting proteins:
ENSP00000225831
P13500-CCL2_HUMAN
for CCL2 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0001525 | angiogenesis | TAS | 18334747 |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | IEA | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for CCL2 Gene
Drugs & Compounds for CCL2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Danazol | Approved | Pharma | Target, inhibitor | 16 | ||
| Mimosine | Approved | Pharma | Target, inhibitor | 0 | ||
| atorvastatin | Approved | Pharma | Competitive, Inhibitor | 0 | ||
| Simvastatin | Approved | Pharma | Competitive, Inhibitor | HMG-CoA reductase inhibitor | 519 | |
| Risperidone | Approved, Investigational | Pharma | Antagonist | SR-2A inhibitor | 492 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CCL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bindarit | 130641-38-2 |
Drug Products
- ApexBio compounds for CCL2
Transcripts for CCL2 Gene
mRNA/cDNA for CCL2 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (231) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- GenScript: Design CRISPR guide RNA sequences for CCL2
miRNA Products
- Search ViGene Biosciences for CCL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
-
ViGene Biosciences ready-to-package AAV shRNAs for CCL2 gene
Clone Products
- Sino Biological Human cDNA Clone for CCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCL2
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11041 ) for CCL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: |
Expression for CCL2 Gene
mRNA differential expression in normal tissues according to GTEx for CCL2 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).
This gene is overexpressed in Amniocyte (39.5) and Islet of Langerhans (29.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCL2 Gene:
CCL2SOURCE GeneReport for Unigene cluster for CCL2 Gene:
Hs.303649mRNA Expression by UniProt/SwissProt for CCL2 Gene:
P13500-CCL2_HUMAN
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level).
Evidence on tissue expression from TISSUES for CCL2 Gene
- Pancreas(4.6)
- Blood(4)
- Nervous system(3.7)
- Heart(3.6)
- Lung(3.6)
- Kidney(3.5)
- Liver(3.4)
- Intestine(3.3)
- Lymph node(3.3)
- Muscle(3.3)
- Spleen(3.2)
- Bone marrow(3.1)
- Skin(3.1)
- Eye(2.6)
- Gall bladder(2.2)
- Stomach(2.1)
- Urine(2.1)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCL2
-
OriGene qPCR primer pairs for CCL2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL2 Gene
Orthologs for CCL2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCL2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCL2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccl12 34 16 |
|
||
| Ccl2 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ccl12 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for CCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CCL2 Gene
Paralogs for CCL2 Gene
(26) SIMAP similar genes for CCL2 Gene using alignment to 2 proteins:
Variants for CCL2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL2 Gene
- CCL2_HUMAN-P13500
- Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000097225 | -- | 34,254,063(+) | CTCAA(A/G/T)TACTC | upstream-variant-2KB | |
| rs1003064174 | -- | 34,254,653(+) | TTCCT(A/G)GCAGA | upstream-variant-2KB | |
| rs1003236569 | -- | 34,257,364(+) | GTCTC(C/T)GTAGA | downstream-variant-500B | |
| rs1003310038 | -- | 34,257,642(+) | GGAAA(C/G)AGTTA | downstream-variant-500B | |
| rs1004292278 | -- | 34,254,684(+) | ACACT(C/G)GCATT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3141n100 | CNV | gain | 25217958 |
| esv3572553 | CNV | gain | 25503493 |
| nsv517423 | CNV | gain+loss | 19592680 |
| nsv519297 | CNV | gain | 19592680 |
| nsv574714 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCL2 Gene
Disorders for CCL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mycobacterium tuberculosis, susceptibility to mycobacterium tuberculosis, protection against, included |
|
|
| neural tube defects |
|
|
| hiv-1 |
|
|
| atherosclerosis |
|
|
| proliferative glomerulonephritis |
|
Search CCL2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCL2
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL2 Gene
Publications for CCL2 Gene
- A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PMID: 16352737) Flores-Villanueva P.O. … Granados J. (J. Exp. Med. 2005) 3 4 22 46 64
- CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. (PMID: 20339010) Hubal M.J. … Clarkson P.M. (J. Appl. Physiol. 2010) 3 22 46 64
- MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. (PMID: 20497022) Liu S.F. … Lin M.C. (Exp. Lung Res. 2010) 3 22 46 64
- Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. (PMID: 19844201) Cavestro G.M. … Di Mario F. (Am. J. Gastroenterol. 2010) 3 22 46 64
- Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness. (PMID: 19148342) Alioglu E. … Ercan E. (Can J Cardiol 2009) 3 22 46 64
Products for CCL2 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CCL2
- EMD Millipore Purified and/or Recombinant CCL2 Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
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- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL2 (CCL2/JE/MCP-1)
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- Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
- AM06749PU-N
- AM26297PU-N
- AM31289AF-N
- AM31290AF-N
- AP09164PU-N
- AP09164PU-S
- AP26385PU-N
- DM2030
- DM2031
- DM2032
- DM2033
- DM2034
- DM2034B
- DM2034HRP
- PM1006A
- PP020B1
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- PP1044B1
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- SM2289P
- TA319166
- TA319701
- TA320225
- TA320226
- TA320227
- TA321546
- TA321547
- TA324861
- TA328374
- TA328375
- TA336723
- TA336724
- TA336914
- TA352601
- TA352602
- TA590148
- TA805016
- CF805016
- TA600025
- TA700025
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
- Origene Custom Protein Services for CCL2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCL2
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- OriGene qPCR primer pairs and template standards for CCL2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL2
- Cell Signaling Technology (CST) Antibodies for CCL2 (CCL2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CCL2
- Sino Biological Recombinant Proteins for CCL2
- Sino Biological Cell Lysates for CCL2
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCL2
- Novus Biologicals proteins and lysates for CCL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CCL2
- Cloud-Clone Corp. Antibodies for CCL2
- Cloud-Clone Corp. Proteins for CCL2
- Taconic Biosciences Mouse Models for CCL2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CCL2
- Addgene plasmids for CCL2
- eBioscience Human CCL2 (MCP-1) Recombinant Protein 5 ug for CCL2
- eBioscience Human CCL2 (MCP-1) ELISA Ready-SET-Go! 2 x 96 tests, Human MCP-1 Instant ELISA 128 tests, Human MCP-1 Instant ELISA 128 tests, Human MCP-1 Platinum ELISA 96 tests, Human MCP-1 Platinum ELISA 96 tests, and Human CCL2 (MCP-1) Single-Use ELISA RSG Standard 4 pack for CCL2
- eBioscience FlowRNA Probe Sets (VA1-11041 ) for CCL2
- antibodies-online Antibodies for CCL2: See all 493
- antibodies-online Kits for CCL2: See all 182
- antibodies-online Proteins for CCL2: See all 164
- Search antibodies-online for peptides
- GeneTex CCL2 antibody for CCL2
- GeneTex Proteins for CCL2
- ViGene Biosciences adenoviral particle packaged cDNA for CCL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCL2 gene
- Search ViGene Biosciences for CCL2
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
- Search Santa Cruz Biotechnology (SCBT) for CCL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- Horizon Cell Lines for CCL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL2
- VectorBuilder custom plasmid, inducible vectors for CCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer