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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL2 Gene

protein-coding GIFtS: 70
GCID: GC17P032582

chemokine (C-C motif) ligand 2

(Previous names: small inducible cytokine A2 (monocyte chemotactic protein...)
(Previous symbol: SCYA2)

Explore 353 diseases affiliated with
CCL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 2¹ ²		Monocyte Chemotactic And Activating Factor² ³
MCAF¹ ² ³ ⁵		Monocyte Chemotactic Protein 1² ³
MCP1¹ ² ³ ⁵		Monocyte Secretory Protein JE² ³
SCYA2¹ ² ³ ⁵		Small-Inducible Cytokine A2² ³
HC11¹ ² ³		MGC9434¹
MCP-1¹ ² ³		HSMCR30²
GDCF-2¹ ²		C-C Motif Chemokine 2²
SMC-CF¹ ²		Monocyte Chemoattractant Protein-1²
Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je)¹ ²		Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2²
Monocyte Chemoattractant Protein 1² ³

External Ids:	HGNC: 10618¹	Entrez Gene: 6347²	Ensembl: ENSG00000108691⁷	OMIM: 158105⁵	UniProtKB: P13500³

Export aliases for CCL2 gene to outside databases

Previous GC identifers: GC17P032352 GC17P034621 GC17P032727 GC17P029606 GC17P028767

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL2:

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted

proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally

related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a

single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or

eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like

psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments

monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic

infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes

into the arterial wall during the disease process of atherosclerosis

Gene Wiki entry for CCL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL2 gene promoter:
c-Fos STAT1 AP-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL2 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q21.1

CCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P032582: view genomic region (about GC identifiers)

Start:	32,582,237 bp from pter	End:	32,584,222 bp from pter
Size:	1,986 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500 (See protein sequence)

Recommended Name: C-C motif chemokine 2 precursor

Size: 99 amino acids; 11025 Da

Subunit: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by

glycosaminoglycan (GAG) side chains of proteoglycans

Subcellular location: Secreted

6/10 PDB 3D structures from and Proteopedia for CCL2 (see all 10):

1DOK (3D)

1DOL (3D)

1DOM (3D)

1DON (3D)

1MCA (3D)

1ML0 (3D)

Secondary accessions: B2R4V3 Q9UDF3

Explore the universe of human proteins at neXtProt for CCL2: NX_P13500

Post-translational modifications:

Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue

converts it from an activator of basophil to an eosinophil chemoattractant¹

View neXtProt modification sites for NX_P13500

CCL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002973.1

ENSEMBL proteins:

ENSP00000462156 ENSP00000225831

Reactome Protein details: P13500
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CCL2 Protein
	R&D Systems Recombinant & Natural Proteins for CCL2 (CCL2/JE/MCP-1)
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	OriGene Purified Protein: CCL2 OriGene Protein Over-expression Lysate: CCL2 OriGene Custom Protein Services for CCL2
	GenScript Purified and Recombinant Proteins for CCL2
	Novus Biologicals CCL2 Proteins Novus Biologicals CCL2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL2
	Uscn Proteins for CCL2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0043025	neuronal cell body	IEA	--

CCL2 for ontologies About GeneDecksing

CCL2 Antibody Products:

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	Novus Biologicals CCL2 Antibodies
	Abcam antibodies for CCL2
	Uscn Antibodies for CCL2
	ThermoFisher Antibody for CCL2

Assay Products for CCL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for CCL2 (CCL2/JE/MCP-1) (see all)
	GenScript Custom Assay Services for CCL2
	Enzo Life Sciences assays for CCL2
	Uscn ELISAs and CLIAs for CCL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P13500

ProtoNet protein and cluster: P13500

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments

monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic

infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes

into the arterial wall during the disease process of atherosclerosis

miRNA Products:		miRTarBase miRNAs that target CCL2: hsa-mir-124 (MIRT004284)

		OriGene 3'-UTR Clone: CCL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL2:
		hsa-miR-577 hsa-miR-323-3p hsa-miR-3910 hsa-miR-374b hsa-miR-3143 hsa-miR-374a hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: CCL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL2 (see all 7) OriGene shRNA RFP: CCL2 OriGene siRNA: CCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL2 (NM_002982)
		Sino Biological Human cDNA Clone for CCL2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL2
		Search LifeMap BioReagents cell lines for CCL2

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL2

Gene Ontology (GO): 7 molecular function terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	--	--
GO:0004672	protein kinase activity	TAS	9973507
GO:0005102	receptor binding	TAS	10542238
GO:0005515	protein binding	--	--
GO:0008009	chemokine activity	IEA	--
GO:0008201	heparin binding	IEA	--
GO:0031727	CCR2 chemokine receptor binding	TAS	18021937

CCL2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CCL2:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
Mouse knock-outs for CCL2: Ccl2^tm1Lex Ccl2^tm1Rol Ccl2^tm1.1Tyos
15/20 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ccl2) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	liver/biliary system	mortality/aging	muscle	nervous system

CCL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CCL2

	Immune response Oncostatin M signaling via MAPK in human cells
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Development VEGF signaling via VEGFR2 - generic cascades

1 R&D Systems Pathway for CCL2

A-beta Uptake & Degradation

5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL2 (see all 30)

	MSP-RON Signaling
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions

3 GeneGo (Thomson Reuters) Pathways for CCL2

	Development VEGF signaling via VEGFR2 - generic cascades
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Immune response Oncostatin M signaling via MAPK in human cells

5 BioSystems Pathways for CCL2

	Oncostatin M Signaling Pathway
	TWEAK Signaling Pathway
	Selenium Pathway
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	IL23-mediated signaling events

5/11 Reactome Pathways for CCL2 (see all 11)

	Peptide ligand-binding receptors
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Chemokine receptors bind chemokines

5/7 Kegg Pathways (Kegg details for CCL2) (see all 7):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	NOD-like receptor signaling pathway
	Chagas disease (American trypanosomiasis)
	Malaria

CCL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for CCL2 (P13500³ ENSP00000225831⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCBP2	O00590³, ENSP00000273145⁴	I2D: score=3 STRING: ENSP00000273145
CCR3	P51677³, ENSP00000350003⁴	I2D: score=2 STRING: ENSP00000350003
CCL11	P51671³, ENSP00000302234⁴	I2D: score=1 STRING: ENSP00000302234
CCR10	P46092³, ENSP00000332504⁴	I2D: score=1 STRING: ENSP00000332504
MMP1	P03956³, ENSP00000322788⁴	I2D: score=1 STRING: ENSP00000322788

About this table

Gene Ontology (GO): 5/68 biological process terms (GO ID links to tree view) (see all 68): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IMP	--
GO:0001525	angiogenesis	TAS	18334747
GO:0001666	response to hypoxia	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0002548	monocyte chemotaxis	IDA	12207323

CCL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL2

3 HMDB Compounds for CCL2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--
Danazol	(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)	17230-88-5	--
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

2 DrugBank Compounds for CCL2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Danazol	--	17230-88-5	target	inhibitor	11216879 11056242
Mimosine	L-Mimosine (see all 6)	500-44-7	target	inhibitor	11936838 15698514

10/150 Novoseek chemical compound relationships for CCL2 gene (see all 150) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	96	1626	11750041 (8), 8616572 (7), 15631778 (7), 17353158 (7) (see all 99)
mcp 1	85	69	20497022 (5), 16091493 (4), 18045859 (3), 20032813 (3) (see all 34)
ccl3	83.4	145	20047691 (5), 16105698 (5), 18070228 (4), 18270300 (4) (see all 81)
groalpha	79.1	60	10540194 (4), 16213701 (4), 16869002 (4), 15044249 (3) (see all 30)
tarc	71	41	12911508 (2), 19536139 (2), 14630994 (2), 11533168 (2) (see all 24)
grogamma	70.8	8	15832427 (2), 10467937 (2), 15972545 (1), 11808935 (1) (see all 5)
vegf	66.3	386	14574083 (8), 15627719 (7), 16273763 (6), 18385799 (6) (see all 99)
mip 1alpha	64.7	9	20205697 (2), 16211583 (1), 15932509 (1), 19506561 (1) (see all 8)
grobeta	62.7	6	15832427 (2), 12556377 (1), 11808935 (1), 17442617 (1)
bindarit	56.9	13	18827968 (4), 10477401 (2), 17460736 (1), 9507220 (1)

Search CenterWatch for drugs/clinical trials and news about CCL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL2 gene:

NM_002982.3

Unigene Cluster for CCL2:

Chemokine (C-C motif) ligand 2

Hs.303649 [show with all ESTs]

Unigene Representative Sequence: BU570769

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000578429 ENST00000580907 ENST00000225831(uc002hhy.3) ENST00000582017

miRNA Products:		OriGene 3'-UTR Clone: CCL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL2:
		hsa-miR-577 hsa-miR-323-3p hsa-miR-3910 hsa-miR-374b hsa-miR-3143 hsa-miR-374a hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: CCL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL2 (see all 7) OriGene shRNA RFP: CCL2 OriGene siRNA: CCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL2 (NM_002982)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL2

Additional cDNA sequence:

AK311308.1 AK311960.1 BC009716.1 BT007329.1 M24545.1 M28226.1 S69738.1 S71513.1

X14768.1

5 DOTS entries:

DT.217745 DT.100795505 DT.100795508 DT.100795510 DT.91845238

24/231 AceView cDNA sequences (see all 231):

R80529 AL697816 NM_002982 CK902136 BI793067 AA047099 AW772091 AI075862

S71513 AI692798 CK902135 AI817756 AW241657 BC009716 BE671641 BQ224954

BM708613 X14768 AI927247 AI097531 BF850412 AW849229 BM704915 BE858648

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:

ECgene alternative splicing isoforms for CCL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACTAGTGT

About this image

CCL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Epicardium

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12)

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

See CCL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL2

SOURCE GeneReport for Unigene cluster: Hs.303649

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL2 (see all 29):

HIV Host Response in human mouse rat

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

Cancer PathwayFinder in human mouse rat

Inflammasomes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL2 gene from 1/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:dkeyp-59a8.3⁶ si:dkeyp-59a8.1⁶ (see all 6)	si:dkeyp-59a8.1 (see all 6)	32(a) 31(a) (see all 6)	many ↔ many many ↔ many (see all 6)	20(38310380-38311158) 20(38282475-38302293)

ENSEMBL Gene Tree for CCL2 (if available)
TreeFam Gene Tree for CCL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL2 gene

CCL15² CCL16² CCL14² CCL24² CCL4L1² CCL11² CCL7² CCL4L2²

CCL3L1² CCL5² CCL23² CCL3L3² CCL4² CCL8² CCL13² CCL26²

CCL3² CCL18²

18/27 SIMAP similar genes for CCL2 using alignment to 2 protein entries: CCL2_HUMAN (see all proteins) (see all similar genes):

MCP1 CCL11 CCL8 CCL7 MCP-3 CCL13

CCL3L1 CCL3L3 CCL4 CCL4L2 LOC728835 CCL4L1

CCL3 CX3CL1 CCL18 CCL26 CCL14 CCL1

CCL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Polymorphism: Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3917886^1,2	C,	--	28765945(+)	`GAGATT/ACTGGA`	1	--	us2k¹		5	NS NA WA	216
rs2857655^1,2	C,F,H,	--	28766555(+)	`GTCCCT/ATGGAA`	1	--	us2k¹		25	NS EA NA	2309
rs1014542^1,2	C	--	28766581(+)	`AGGAGA/CATAGC`	1	--	us2k¹		2	NA	4
rs3760398^1,2	C,F,	--	28766700(-)	`GGGCAG/CACAGC`	1	--	us2k¹		1	EA	120
rs3760397^1,2	C,H	--	28766720(-)	`GTCCTC/TAGCAT`	1	--	us2k¹		3	NS NA	230
rs11575010^1,2	F,	--	28767242(+)	`TAAGCT/CGGCAG`	1	--	us2k¹		3	NA CSA WA	162
rs3917904^1,2	C	--	28767273(+)	`CTAGTT/ATCCTC`	1	--	us2k¹		4	NS NA	96
rs74988151^1,2	F,	--	28767539(+)	`CCTCCT/CGCTTG`	1	--	us2k¹		1	WA	118
rs11575011^1,2	F	--	28767550(+)	`ACTCCG/TCCCTC`	1	--	us2k¹		1	NA	38
rs11575012^1,2	F	--	28767553(+)	`CCGCCC/TTCTCT`	1	--	us2k¹ trp³		1	NA	40

HapMap Linkage Disequilibrium report for CCL2 (32582237 - 32584222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCL2: --
Human Gene Mutation Database (HGMD): CCL2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL2

DNA2.0 Custom Variant and Variant Library Synthesis for CCL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL2 for disorders           About GeneDecksing

OMIM gene information: 158105
OMIM disorders: 609423  182940  607948
20/353 diseases for CCL2 (see all 353):    About MalaCards

rheumatoid arthritis erdheim-chester disease alpha 1-antitrypsin deficiency tick-borne encephalitis

psoriasis pulmonary alveolar proteinosis adult-onset still's disease atherosclerosis

steroid-resistant nephrotic syndrome relapsing-remitting multiple sclerosis arthritis periapical granuloma

coronary artery disease, modifier of venezuelan equine encephalitis spina bifida hermansky-pudlak syndrome

arterial occlusive disease hypersensitivity reaction type ii disease migraine without aura sympathetic ophthalmia

15 diseases from the University of Copenhagen DISEASES database for CCL2:

Atherosclerosis Kidney disease Diabetes mellitus Arthritis

Heart disease Hypersensitivity reaction type II disease Asthma Cancer

Multiple sclerosis Connective tissue disease Hypertension Pneumonia

Interstitial lung disease Endometriosis Encephalitis

10/96 Novoseek disease relationships for CCL2 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	86.3	568	15104334 (4), 11739289 (4), 17977946 (4), 7891256 (3) (see all 99)
necrosis	82.7	1069	15626982 (5), 7635182 (3), 15223398 (3), 16407046 (3) (see all 99)
atherosclerosis	79.6	284	17521622 (5), 15894320 (4), 15519012 (4), 12578870 (3) (see all 99)
tumors	67.6	1198	15883814 (5), 9111518 (5), 16278381 (5), 15626982 (5) (see all 99)
atherosclerotic plaque	65.6	35	14739122 (2), 16934270 (1), 19566488 (1), 19656094 (1) (see all 23)
bronchoalveolar lavage fluid	56.3	42	8890891 (3), 10515417 (2), 10489845 (2), 8616572 (1) (see all 30)
rheumatoid arthritis	56.3	60	16740681 (3), 12826377 (2), 11411959 (2), 14626631 (2) (see all 40)
lupus nephritis	53.8	45	11780369 (7), 8558841 (6), 16334978 (4), 15119544 (2) (see all 17)
cardiovascular diseases	53.7	39	19566488 (3), 15030267 (3), 15627719 (2), 11919402 (1) (see all 20)
insulin resistance	53.6	86	18762729 (5), 15349727 (4), 19361458 (4), 15063799 (3) (see all 33)

Genetic Association Database (GAD): CCL2
Human Genome Epidemiology (HuGE) Navigator: CCL2 (260 documents)

Export disorders for CCL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL2 gene, integrated from 9 sources (see all 3690):
(articles sorted by number of sources associating them with CCL2)

Utopia: connect your pdf to the dynamic
world of online information

A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PubMed id 16352737)^{1, 2, 4, 9} Flores-Villanueva P.O.... Granados J. (2005)
Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness. (PubMed id 14620921)^{1, 4, 9} Tabara Y....Miki T. (2003)
CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. (PubMed id 16116069)^{1, 4, 9} McDermott D.H....Benjamin E.J. (2005)
MCP-1 gene (SCYA2) and schizophrenia: a case-control association study. (PubMed id 15389752)^{1, 4, 9} Mundo E....Gennarelli M. (2005)
Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians. (PubMed id 15288699)^{1, 4, 9} Pola R....Pola P. (2004)
Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism. (PubMed id 16050950)^{1, 4, 9} Zietz B....Schaffler A. (2005)
Association study of functional genetic variants of innate immunity related genes in celiac disease. (PubMed id 16078996)^{1, 4, 9} Rueda B....Koeleman B.P. (2005)
MCP-1 gene regulatory region polymorphism in Chinese children with mild, moderate and near-fatal asthma. (PubMed id 15005768)^{1, 4, 9} Yao T.C....Huang J.L. (2004)
Polymorphism of monocyte chemoattractant protein 1 in Crohn's disease. (PubMed id 12904997)^{1, 4, 9} Herfarth H....Rogler G. (2003)
Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. (PubMed id 11544456)^{1, 4, 9} Szalai C....Falus A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6347	HGNC: 10618	AceView: CCL2	Ensembl:ENSG00000108691	euGenes: HUgn6347
ECgene: CCL2	Kegg: 6347	H-InvDB: CCL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCL2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CCL2
SeattleSNPs	http://pga.gs.washington.edu/data/scya2/

Intellectual Property for CCL2 gene
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Patent Information for CCL2 gene:
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Licensable Technologies for CCL2 gene:

Weizmann Institute:

CCL2 for the Treatment of Inflammation

GeneCards and IP:
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CCL2 Gene

chemokine (C-C motif) ligand 2

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CCL2 (Gene Symbol)
Chemokine (C-C Motif) Ligand 2
MCAF
MCP1
SCYA2
HC11
MCP-1
GDCF-2
SMC-CF
Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je)
Monocyte Chemoattractant Protein 1
Monocyte Chemotactic And Activating Factor
Monocyte Chemotactic Protein 1
Monocyte Secretory Protein JE
Small-Inducible Cytokine A2
MGC9434
HSMCR30
C-C Motif Chemokine 2
Monocyte Chemoattractant Protein-1
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2

Microalbuminuria
Nephritis
sepsis
Endometriosis
Nephropathy Membranous
Dermatitis Atopic
insulin sensitivity
Vitreoretinopathy Proliferative
Atherosclerosis
Rh Incompatibility
Neovascularization
ALVEOLITIS
Asthma
cell damage
NEPHROPATHY OBSTRUCTIVE
Uveitis
Coronary Atherosclerosis
Dyslipidemia
RENAL DISEASE
Osteolysis
Nasal Polyps
Bronchoalveolar Lavage Fluid
Sarcoidosis Pulmonary
Nephropathy IGA
Multiple Sclerosis
HNSCC
Inflammation
glomerulosclerosis
Demyelinating Diseases
Diabetic Nephropathies
PULMONARY GRANULOMA
Proteinuria
Monocytic leukemia
Hyperhomocysteinemia
immunodeficiency
Psoriasis
HIV encephalitis
Pulmonary Disease Chronic Obstructive
Hepatitis Alcoholic
aqueous humor
Sarcoidosis
Rheumatoid Arthritis
Pneumonia
bacterial peritonitis
Tumors
Cardiovascular Diseases
Kawasaki Disease
Necrosis
Asthma allergic
Pulmonary Alveolar Proteinosis
Carotid Atherosclerosis
virus infection
TRANSFUSION REACTION HEMOLYTIC
FIBROSIS IDIOPATHIC PULMONARY
Coal workers pneumoconiosis
Nephrotic Syndrome Minimal Change
Encephalomyelitis
Autoimmune Diseases
Pulmonary Fibrosis
Vasculitis
Hyperplasia
atherosclerotic plaque
Liver Fibrosis
Lung Diseases Interstitial
Periapical Granuloma
Bacterial Infections
Osteoarthritis
Arterial Occlusive Diseases
Renal fibrosis
Myopathies Idiopathic Inflammatory
Leukemia Mast Cell
Arteriosclerosis
Proliferative glomerulonephritis
Albuminuria
Inflammatory Bowel Diseases
Coronary Artery Disease
Aortic Aneurysm Abdominal
Proliferative diabetic retinopathy
Response Acute Phase
Insulin Resistance
Chronic periodontitis
OBESITY
Lung diseases
restenosis
Vascular Diseases
Granuloma
Lupus Nephritis
Pleurisy Tuberculous
Glomerulonephritis
NIDDM
Sclerosis Systemic
Peritonitis
Encephalitis
CNS Diseases
Arthritis
Lupus Erythematosus Systemic

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CCL2 Gene

chemokine (C-C motif) ligand 2

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