V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CCL2 Gene

protein-coding GIFtS: 69

GC17P029606

chemokine (C-C motif) ligand 2
(Previous names: small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SCYA2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GDCF-2 ^¹, ²
HC11 ^¹, ², ³
HSMCR30 ^²
MCAF ^¹, ², ³, ⁵
MCP-1 ^¹, ², ³
MCP1 ^¹, ², ³, ⁵
MGC9434 ^¹, ²
SCYA2 ^², ³, ⁵
SMC-CF ^¹, ²

Descriptions
Monocyte chemoattractant protein 1 ^³
Monocyte chemotactic and activating factor ^², ³
Monocyte chemotactic protein 1 ^³
Monocyte secretory protein JE ^², ³
Small-inducible cytokine A2 ^³
chemokine (C-C motif) ligand 2 ^²
monocyte chemoattractant protein-1 ^²
small inducible cytokine A2 ^²
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) ^¹, ²
small inducible cytokine subfamily A (Cys-Cys), member 2 ^²

External Ids
HGNC: 10618¹
Entrez Gene: 6347²
UniProtKB: P13500³
Ensembl: ENSG00000108691⁷

Search outside databases for aliases for CCL2 gene

Previous GC identifers: GC17P032352 GC17P034621 GC17P032727

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCL2:

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a

family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein

encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this

subfamily are characterized by two cysteines separated by a single amino acid. This cytokine

displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils.

It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates,

like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and

CCR4. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or

eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of

diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or

atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the

disease process of atherosclerosis

Gene Wiki entry for CCL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCL2 gene

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q21.1

CCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P029606: (about GC identifiers)

Start:	29,606,409 bp from pter
End:	29,608,335 bp from pter
Size:	1,927 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500 (See protein sequence)

Recommended Name: C-C motif chemokine 2 precursor

Size: 99 amino acids; 11025 Da

Subunit: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial

cells by glycosaminoglycan (GAG) side chains of proteoglycans

Subcellular location: Secreted

PDB structures from and Proteopedia :

1DOK (3D)

1DOL (3D)

1DOM (3D)

1DON (3D)

1MCA (3D)

1ML0 (3D)

2BDN (3D)

2NZ1 (3D)

Secondary accessions: Q9UDF3

Post-translational modifications:

Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the

N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant¹

REFSEQ proteins: NP_002973.1

ENSEMBL proteins:

ENSP00000225831

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CCL2
	Millipore Purified and/or Recombinant CCL2 Protein
	Sigma-Aldrich AQUA Peptides for CCL2
	R&D Systems Recombinant & Natural Proteins for CCL2 (CCL2/JE/MCP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MCP1)
	Human Recombinant Proteins from Abnova (CCL2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10942204
GO:0005737	cytoplasm	IEA	--
GO:0043025	cell soma	IEA	--

About this table

Antibodies for CCL2:

	Invitrogen Antibodies for CCL2
	Millipore Mono- and Polyclonal Antibodies for the study of CCL2
	Sigma-Aldrich Antibodies for CCL2
	R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
	Cell Signaling Technology (CST) Antibodies for CCL2
	Antibodies from Abcam (MCP1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CCL2

Assays for CCL2:

	Invitrogen Assays for CCL2
	Millipore Kits and Assays for the Analysis of CCL2
	R&D Systems Flow Cytometry Kits for CCL2 (CCL2/JE/MCP-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13500

ProtoNet protein and cluster: P13500

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCL2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002982

Applied Biosystems Silencer® siRNAs for CCL2

Sigma-Aldrich siRNA and siRNA Panels for CCL2

Sigma-Aldrich shRNA Panels and shRNA for CCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002982
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002982
untagged cDNA clone in CMV expression vector: NM_002982

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002982

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or

eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of

diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or

atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the

disease process of atherosclerosis

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccl2):

	hematopoietic system	immune system	nervous system	pigmentation
reproductive system	skin/coat/nails	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein-coupled receptor binding	IEA	--
GO:0004672	protein kinase activity	TAS	9973507
GO:0004871	signal transducer activity	TAS	10198043 10770925
GO:0008009	chemokine activity	TAS	10623817
GO:0031727	CCR2 chemokine receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for CCL2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Renin-Angiotensin Signaling
HMGB1 Signaling
IL-17 Signaling
LXR/RXR Activation
Glucocorticoid Receptor Signaling

GeneDecks CCL2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CCL2

5/152 Interacting proteins for CCL2 (ENSP00000225831³ P13500¹) via UniProtKB, MINT, and/or STRING (see all 152 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAMMAHV.M3 GAMMAHV.M3 (xeno)	O41925¹	EBI-1034732, EBI-1034728
CCR2	ENSP00000292301³	STRING (score=.999)
CCR5	ENSP00000292303³	STRING (score=.994)
IL1B	ENSP00000263341³	STRING (score=.985)
IL10	ENSP00000356066³	STRING (score=.984)

About this table

5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0002548	monocyte chemotaxis	IDA	12207323
GO:0006468	protein amino acid phosphorylation	TAS	9670957
GO:0006874	cellular calcium ion homeostasis	TAS	9670957
GO:0006916	anti-apoptosis	IDA	12753088

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CCL2
10/49 Novoseek chemical compound relationships for CCL2 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	96.03	1518	11750041 (8), 8616572 (7), 15631778 (7), 17353158 (7) (see all 99)
mcp 1	82.98	45	16091493 (4), 18045859 (3), 18353886 (3), 19243600 (2) (see all 25)
ccl3	81.85	114	16105698 (5), 18070228 (4), 18270300 (4), 12010572 (3) (see all 64)
groalpha	79.10	58	10540194 (4), 16213701 (4), 16869002 (4), 15044249 (3) (see all 28)
grogamma	69.38	8	15832427 (2), 10467937 (2), 15972545 (1), 11808935 (1) (see all 5)
tarc	68.87	35	12911508 (2), 11533168 (2), 15142882 (2), 14630994 (2) (see all 20)
grobeta	61.63	6	15832427 (2), 12556377 (1), 11808935 (1), 17442617 (1)
bindarit	61.34	13	18827968 (4), 10477401 (2), 17460736 (1), 9507220 (1)
mip 1alpha	56.76	4	16211583 (1), 15932509 (1), 10559777 (1), 19308263 (1)
il 10	53.76	25	15975968 (3), 15544634 (3), 15281432 (2), 16205314 (1) (see all 14)

About this table

1 PharmGKB drug compound relationship for CCL2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	10502563

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCL2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002982

Sigma-Aldrich siRNA and siRNA Panels for CCL2

Sigma-Aldrich shRNA Panels and shRNA for CCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002982

REFSEQ mRNAs for CCL2 gene:

NM_002982.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002982

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002982
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002982
                                 untagged cDNA clone in CMV expression vector: NM_002982

Additional cDNA sequence:

AK311308.1 AK311960.1 BC009716.1 BT007329.1 M24545.1 M28226.1 S69738.1 S71513.1

X14768.1

5 DOTS entries:

DT.217745 DT.100795505 DT.100795508 DT.100795510 DT.91845238

24/231 AceView cDNA sequences (see all 231 ):

AW849229 BU192217 AI692798 AL697816 R80529 T29155 H99781 AW772091

X14768 BI793067 BC009716 AA047099 BM704915 S71513 NM_002982 BM708613

AW241657 BE671641 AI927247 AI097531 CK902135 AI817756 BQ224954 AI075862

highest scoring ESTs for CCL2:

AA024753 AA024754 AA047099 AA047236 AA317121 AA327711 AA362116 AA425102 AA429323 AA614521

Unigene Cluster for CCL2:

Chemokine (C-C motif) ligand 2

Hs.303649 [show with all ESTs]

Unigene Representative Sequence: BU570769

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL2

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for CCL2

1 Ensembl transcript including schematic representation:

ENST00000225831

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCL2

¹ / ² / ³

5 probe-sets matching CCL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
874_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.78	M26683	0.80	1.00	0.91	1
875_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.19	M26683	0.80	1.00	0.91	1
34375_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.04	M28225	0.20	1.00	0.72	1
216598_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S69738	0.60	1.00	0.82	1
216598_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CCL2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTACTAGTGT

SOURCE GeneReport for Unigene cluster: Hs.303649
Expression variation in blood from EXPOLDB for CCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCL2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCL2¹	--	chemokine (C-C motif) ligand 2	84.37(n) 79.17(a)	403981 NM_001003297.1 NP_001003297.1
chimpanzee (Pan troglodytes)	CCL2¹	--	chemokine (C-C motif) ligand 2	98.65(n) 100(a)	748205 XM_001174551.1 XP_001174551.1
cow (Bos taurus)	CCL2¹	--	chemokine (C-C motif) ligand 2	81.29(n) 72.45(a)	281043 NM_174006.2 NP_776431.1
rat (Rattus norvegicus)	Ccl12¹	--	chemokine (C-C motif) ligand 12	75.09(n) 64.21(a)	287562 XM_213425.2 XP_213425.1
mouse (Mus musculus)	Ccl2⁵ Ccl12¹	11 (46.50 cM)⁵	chemokine (C-C motif) ligand 2⁵ chemokine (C-C motif) ligand 12¹	74.74(n)¹ 68.42(a)¹	20293¹ NM_011331.2¹ NP_035461.2¹ AC012294⁵ AF065929⁵ (see all 23)

About this table Species with no ortholog for CCL2

ENSEMBL Gene Tree for CCL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCL2 gene

CCL11² CCL13² CCL7² CCL26² CCL8² CCL16² CCL24²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: CCL2_HUMAN, P13500

Polymorphism: Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility

[MIM:607948]

10/30 NCBI SNPs in CCL2 are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 51)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2857656^1,2	A,C,F,H,O	29606120(+)	`CTTCAG/CAGAAA`	1	--	ng5¹		14		NS NA EU EA WA	1246
	rs13900^1,2	A,C,F	29608024(+)	`ACACCC/TTGTTT`	1	--	ut3¹ ese³		6		MN NA NS	548
	rs2190971^1,2	A,C,O	29608548(-)	`AAGACT/GGGAAG`	1	--	ng3¹		2		NS	92
	rs3760396^1,2	C,F,H	29605554(-)	`GTTGCC/GTGCTT`	1	--	ng5¹		15		EA NS NA EU WA	2744
	rs2857655^1,2	C,F,H	29605365(+)	`GTCCCT/ATGGAA`	1	--	ng5¹		18		NS EU EA WA NA	1701
	rs3760399^1,2	C,F,H	29604671(-)	`TGGAGT/CGGCCA`	1	--	ng5¹		12		NS EU EA WA	1134
	rs2215182^1,2	A,C	29608184(-)	`CTGTGA/GTTCAA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs3091332^1,2	C,F	29604933(+)	`ATGCCA/TTTACT`	1	--	ng5¹		9		NA NS	792
--	rs3917886^1,2	C	29604755(+)	`GAGATT/ACTGGA`	1	--	ng5¹		2		NS	94
--	rs11575012^1,2	F	29606363(+)	`CCGCCC/TTCTCT`	1	--	ng5¹ trp³		1		NA	40

About this table

HapMap Linkage Disequilibrium images for CCL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 158105

10/97 Novoseek disease relationships for CCL2 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	85.43	497	15104334 (4), 11739289 (4), 17977946 (4), 7891256 (3) (see all 99)
necrosis	82.01	916	15626982 (5), 7635182 (3), 15223398 (3), 16407046 (3) (see all 99)
atherosclerosis	78.49	250	17521622 (5), 15894320 (4), 15519012 (4), 12578870 (3) (see all 99)
tumors	66.50	1055	15883814 (5), 9111518 (5), 15626982 (5), 16278381 (5) (see all 99)
atherosclerotic plaque	64.27	26	14739122 (2), 16934270 (1), 15514167 (1), 17276989 (1) (see all 16)
rheumatoid arthritis	56.17	56	16740681 (3), 12826377 (2), 11411959 (2), 14626631 (2) (see all 37)
bronchoalveolar lavage fluid	54.74	40	8890891 (3), 10515417 (2), 10489845 (2), 8616572 (1) (see all 28)
fibrosis idiopathic pulmonary	52.79	24	10515417 (2), 8118632 (2), 11031344 (1), 19060230 (1) (see all 14)
lupus nephritis	51.93	39	11780369 (7), 8558841 (6), 16334978 (4), 15119544 (2) (see all 14)
diabetic nephropathies	50.88	65	11835523 (7), 11012884 (6), 17045117 (4), 10916091 (3) (see all 31)

About this table

Human Gene Mutation Database: CCL2
Genetic Association Database: CCL2
Human Genome Epidemiology Navigator: CCL2 (159 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2848 PubMed articles for CCL2 gene (see all 2848 ):

A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PubMed id 16352737)^{1, 3, 4, 6} Flores-Villanueva P.O.... Granados J. (2005)
Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness. (PubMed id 14620921)^{1, 3, 6} Tabara Y....Miki T. (2003)
CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. (PubMed id 16116069)^{1, 3, 6} McDermott D.H....Benjamin E.J. (2005)
MCP-1 gene (SCYA2) and schizophrenia: a case-control association study. (PubMed id 15389752)^{1, 3, 6} Mundo E....Gennarelli M. (2005)
Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians. (PubMed id 15288699)^{1, 3, 6} Pola R....Pola P. (2004)
Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism. (PubMed id 16050950)^{1, 3, 6} Zietz B....Schaffler A. (2005)
The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese. (PubMed id 15611878)^{1, 3, 6} Ye D.Q....Zhang X.J. (2005)
Association study of functional genetic variants of innate immunity related genes in celiac disease. (PubMed id 16078996)^{1, 3, 6} Rueda B....Koeleman B.P. (2005)
MCP-1 gene regulatory region polymorphism in Chinese children with mild, moderate and near-fatal asthma. (PubMed id 15005768)^{1, 3, 6} Yao T.C....Huang J.L. (2004)
Polymorphism of monocyte chemoattractant protein 1 in Crohn's disease. (PubMed id 12904997)^{1, 3, 6} Herfarth H....Rogler G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6347	HGNC: 10618	AceView: CCL2	Ensembl:ENSG00000108691	euGenes: HUgn6347
ECgene: CCL2	H-InvDB: CCL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CCL2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CCL2
SeattleSNPs	http://pga.gs.washington.edu/data/scya2/

Licensable Technologies for CCL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CCL2 gene:

Weizmann Institute:

CCL2 for the Treatment of Inflammation

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CCL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCL2		Antibodies for CCL2
	Explore super-pooled esiRNAs		Proteins for CCL2
	Lentivirus-delivered shRNAs for CCL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CCL2)
	Search for Antibodies
	Chimera RNAi (CCL2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CCL2

	Recombinant Proteins (MCP1)
	Antibodies (MCP1)

Search OriGene for CCL2

Search Tocris compounds for CCL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCL2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CCL2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

CCL2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CCL2

Summaries
for CCL2

Genomic Location
for CCL2

Proteins
for CCL2

Protein Domains/
Families
for CCL2

Gene Function
for CCL2

Pathways & Interactions
for CCL2

Drugs & Compounds
for CCL2

Transcripts
for CCL2

Expression
for CCL2

Orthologs
for CCL2

Paralogs
for CCL2

SNPs/Variants
for CCL2

Disorders & Mutations
for CCL2

Medical News
for CCL2

Publications
for CCL2

Search for CCL2

Genome Databases showing CCL2

Other Databases showing CCL2

Specialized Databases showing CCL2

Licensable Technologies
for CCL2

Services
for CCL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCL2 (Gene Symbol)
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
MGC9434
SCYA2
SMC-CF
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Monocyte chemotactic protein 1
Monocyte secretory protein JE
Small-inducible cytokine A2
chemokine (C-C motif) ligand 2
monocyte chemoattractant protein-1
small inducible cytokine A2
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
small inducible cytokine subfamily A (Cys-Cys), member 2

CCL2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CCL2

Summariesfor CCL2

Genomic Locationfor CCL2

Proteinsfor CCL2

Protein Domains/Familiesfor CCL2

Gene Functionfor CCL2

Pathways & Interactionsfor CCL2

Drugs & Compoundsfor CCL2

Transcriptsfor CCL2

Expression for CCL2

Orthologsfor CCL2

Paralogsfor CCL2

SNPs/Variantsfor CCL2

Disorders & Mutationsfor CCL2

Medical Newsfor CCL2

Publicationsfor CCL2

Search for CCL2

Genome Databases showing CCL2

Other Databases showing CCL2

Specialized Databases showing CCL2

Licensable Technologiesfor CCL2

Servicesfor CCL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCL2

Summaries
for CCL2

Genomic Location
for CCL2

Proteins
for CCL2

Protein Domains/
Families
for CCL2

Gene Function
for CCL2

Pathways & Interactions
for CCL2

Drugs & Compounds
for CCL2

Transcripts
for CCL2

Expression
for CCL2

Orthologs
for CCL2

Paralogs
for CCL2

SNPs/Variants
for CCL2

Disorders & Mutations
for CCL2

Medical News
for CCL2

Publications
for CCL2

Licensable Technologies
for CCL2

Services
for CCL2