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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL19 Gene

protein-coding GIFtS: 57
GCID: GC09M034692

chemokine (C-C motif) ligand 19

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA19)

Explore 46 diseases affiliated with
CCL19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 19¹ ²		Macrophage Inflammatory Protein 3 Beta² ³
ELC¹ ² ³ ⁵		Small-Inducible Cytokine A19² ³
SCYA19¹ ² ³ ⁵		MIP-3-Beta¹
MIP3B² ³ ⁵		CK Beta-11² ³
CKb11¹ ²		EBI1 Ligand Chemokine² ³
MIP-3b¹ ²		Beta Chemokine Exodus-3²
Exodus-3¹		C-C Motif Chemokine 19²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19¹ ²		CC Chemokine Ligand 19²
Beta-Chemokine Exodus-3² ³		EBI1-Ligand Chemokine²
Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine² ³		Macrophage Inflammatory Protein 3-Beta²

External Ids:	HGNC: 10617¹	Entrez Gene: 6363²	Ensembl: ENSG00000172724⁷	OMIM: 602227⁵	UniProtKB: Q99731³

Export aliases for CCL19 gene to outside databases

Previous GC identifers: GC09M035001 GC09M034859 GC09M034680 GC09M034681 GC09M034682 GC09M034683 GC09M034685 GC09M034688 GC09M034643

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL19:

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of

secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized

by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and

homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to

secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731

Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte

recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell

migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent

chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes

Gene Wiki entry for CCL19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL19 gene promoter:
AML1a p53 SREBP-1c FOXD1 IRF-1 SREBP-1b SREBP-1a ARP-1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL19 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13

CCL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL19 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M034692: view genomic region (about GC identifiers)

Start:	34,689,564 bp from pter	End:	34,691,274 bp from pter
Size:	1,711 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731 (See protein sequence)

Recommended Name: C-C motif chemokine 19 precursor

Size: 98 amino acids; 10993 Da

Subcellular location: Secreted

Secondary accessions: O00697 O00736

Explore the universe of human proteins at neXtProt for CCL19: NX_Q99731

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99731

CCL19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006265.1

ENSEMBL proteins:

ENSP00000308815 ENSP00000368077

Reactome Protein details: Q99731
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL19 (CCL19/MIP-3 beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CCL19 OriGene Custom Protein Services for CCL19
	GenScript Purified and Recombinant Proteins for CCL19
	Novus Biologicals CCL19 Proteins Novus Biologicals CCL19 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL19
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL19 for ontologies About GeneDecksing

CCL19 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL19 (CCL19/MIP-3 beta)
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	GenScript Custom Superior Antibodies Services for CCL19
	Novus Biologicals CCL19 Antibodies
	Search for Antibodies for CCL19 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for CCL19

Assay Products for CCL19:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for CCL19 (CCL19/MIP-3 beta) (see all)
	GenScript Custom Assay Services for CCL19
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL19 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q99731

ProtoNet protein and cluster: Q99731

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731

Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte

recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell

migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent

chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes

miRNA Products:		OriGene 3'-UTR Clone: CCL19 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL19
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL19:
		hsa-miR-2355-5p hsa-miR-342-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CCL19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL19 (see all 7) OriGene shRNA RFP: CCL19 OriGene siRNA: CCL19
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL19

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL19

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL19 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL19 (NM_006274)
		Sino Biological Human cDNA Clone for CCL19
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL19
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL19

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL19
		Search LifeMap BioReagents cell lines for CCL19

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL19

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IDA	15778365
GO:0031732	CCR7 chemokine receptor binding	ISS	--
GO:0031735	CCR10 chemokine receptor binding	IDA	10706668
GO:0048020	CCR chemokine receptor binding	IPI	--

CCL19 for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccl19):

hematopoietic system

immune system

CCL19 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Apoptosis and survival_Lymphotoxin-beta receptor signaling

	Apoptosis and survival Lymphotoxin-beta receptor signaling	1.00			LT-BetaR Pathway	0.46
	Apoptosis and survival_Lymphotoxin-beta receptor signaling	1.00

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCL19

Apoptosis and survival Lymphotoxin-beta receptor signaling

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL19 (see all 28)

	LT-BetaR Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions

1 GeneGo (Thomson Reuters) Pathway for CCL19

Apoptosis and survival Lymphotoxin-beta receptor signaling

5/8 Reactome Pathways for CCL19 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2 Kegg Pathways (Kegg details for CCL19):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCL19 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL19

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/156 Interacting proteins for CCL19 (Q99731³ ENSP00000308815⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 156)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCR7	P32248³, ENSP00000246657⁴	I2D: score=5 STRING: ENSP00000246657
CCR10	P46092³, ENSP00000332504⁴	I2D: score=3 STRING: ENSP00000332504
CCBP2	O00590³, ENSP00000273145⁴	I2D: score=2 STRING: ENSP00000273145
CXCL13	O43927³, ENSP00000286758⁴	I2D: score=2 STRING: ENSP00000286758
CCL22	O00626³, ENSP00000219235⁴	I2D: score=3 STRING: ENSP00000219235

About this table

Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001768	establishment of T cell polarity	IDA	12729902
GO:0001771	immunological synapse formation	ISS	--
GO:0002407	dendritic cell chemotaxis	IDA	15778365
GO:0002408	myeloid dendritic cell chemotaxis	IDA	14592837
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	ISS	--

CCL19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL19 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL19
10/11 Novoseek chemical compound relationships for CCL19 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mip-3beta	85.6	3	12437666 (1), 15142882 (1)
larc	80.9	8	9365118 (3), 10027395 (2), 10934220 (1), 10967023 (1)
tarc	77.1	10	9365118 (3), 11358988 (2), 15890946 (2), 11154210 (1)
ccl3	70.9	6	15256380 (2), 20015995 (1), 15784733 (1), 19726994 (1) (see all 5)
peg-10	69.6	3	16225771 (2)
teck	69.1	4	10706668 (3), 10967023 (1)
rantes	65.5	5	10559506 (1), 11160268 (1), 14512544 (1), 15233729 (1) (see all 5)
calcium	16.6	6	9507024 (2), 12351815 (1), 10201891 (1), 19012040 (1)
pge2	14.2	4	12149218 (1)
dextran	10	2	14742992 (1), 14512544 (1)

Search CenterWatch for drugs/clinical trials and news about CCL19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL19 gene:

NM_006274.2

Unigene Cluster for CCL19:

Chemokine (C-C motif) ligand 19

Hs.50002 [show with all ESTs]

Unigene Representative Sequence: BI521023

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311925(uc003zvn.3 uc010mkf.3) ENST00000485502 ENST00000378800

miRNA Products:		OriGene 3'-UTR Clone: CCL19 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL19
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL19:
		hsa-miR-2355-5p hsa-miR-342-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CCL19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL19 (see all 7) OriGene shRNA RFP: CCL19 OriGene siRNA: CCL19
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL19

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL19 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL19 (NM_006274)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL19
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL19

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL19 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL19
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL19

Additional cDNA sequence:

AB000887.1 AK311945.1 BC027968.1 CR456868.1 U77180.1 U88321.1

3 DOTS entries:

DT.412582 DT.121194064 DT.92005478

24/84 AceView cDNA sequences (see all 84):

BQ005590 NM_006274 AI707962 CR623730 AI718724 AB000887 BF001364 BI837646

AI096411 BX105269 CD696746 N80273 BC027968 AI719120 CR456868 AV727235

BM768365 BM720436 W07401 AI707984 BU740359 AI253509 U77180 CD706787

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGCTAC

About this image

CCL19 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCL19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL19

SOURCE GeneReport for Unigene cluster: Hs.50002

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731

Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon

and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL19 (see all 6):

Antigen Presenting Cells in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL19 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCL19
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL19

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL19 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCL19⁶	--	43(a)	1 → many	Un(17081160-17083683)
zebrafish (Danio rerio)	Actinopterygii	zgc:194112⁶ si:dkey-200l5.2⁶ (see all 3)	si:dkey-200l5.2 (see all 3)	28(a) 27(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(14575941-14578542) 10(17807201-17810322)

ENSEMBL Gene Tree for CCL19 (if available)
TreeFam Gene Tree for CCL19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL19 gene

CCL21²

14 SIMAP similar genes for CCL19 using alignment to 3 protein entries: CCL19_HUMAN (see all proteins):

CCL16 CCL26 CCL21 CCL22 CCL3 CCL5

CCL15 CCL24 CCL4 CCL17 CCL3L1 CCL3L3

CCL20 CCL18

CCL19 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145844478^1,2		--	34689266(+)	`TGAGAC/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs145242602^1,2		--	34689470(+)	`GACAGA/CTCTAT`	1	--	ds500¹		0	--	--	--	--
rs149173661^1,2		--	34689515(+)	`TAGTTA/CAGCAG`	1	--	ds500¹		0	--	--	--	--
rs2227302^1,2	C,F,H,	--	34689695(-)	`CCTGAC/TCAGCC`	1	--	ut3¹ ese³		15		MN NS EA NA	1670
rs143226048^1,2		--	34689724(+)	`GAAGCC/TTGGTC`	1	--	ut3¹		0	--	--	--	--
rs148292070^1,2	C,F,	--	34689791(+)	`GACTCC/TGGGCT`	1	--	ut3¹		1		EU	1071
rs2233877^1,2	C,H,	--	34689792(-)	`GAGCCC/TGGAGT`	1	--	ut3¹		4		NS EA	420
rs200348934^1,2	F	--	34689801(+)	`TCCCTC/TTGCAC`	1	--	ut3¹		1		EU	1111
rs192142582^1,2	C,	--	34689815(+)	`CATAGC/GTTAAC`	1	--	ut3¹		0	--	--	--	--
rs146255999^1,2	C,F,	--	34689830(+)	`GCGGCG/ACTTCA`	2	/R /C	mis¹		1		NA	4552

HapMap Linkage Disequilibrium report for CCL19 (34689564 - 34691274 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCL19: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL19

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL19 for disorders           About GeneDecksing

OMIM gene information: 602227    OMIM disorders: --

20/46 diseases for CCL19 (see all 46):    About MalaCards

chronic inflammatory demyelinating polyradiculoneuropathy guillain-barre syndrome inclusion body myositis central nervous system lymphoma

allergic contact dermatitis common variable immunodeficiency contact dermatitis polyradiculoneuropathy

klebsiella mantle cell lymphoma fatty liver disease lymphocytic leukemia

squamous cell carcinoma peripheral t-cell lymphoma adult t-cell leukemia liver disease

chronic lymphocytic leukemia acute lymphocytic leukemia myositis herpes simplex

10/14 Novoseek disease relationships for CCL19 gene (see all 14) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
b-all	44.4	3	16225771 (3)
inflammation	34.7	4	16118351 (1), 19747210 (1), 16618517 (1)
leukemia lymphocytic chronic	32.2	1	17082584 (1)
autoimmune diseases	27.8	1	16887149 (1)
necrosis	23.3	5	12949243 (1), 10027395 (1), 16282532 (1), 11298554 (1) (see all 5)
lymphadenopathy	17.1	1	11929789 (1)
atherosclerotic plaque	15.1	2	10027395 (2)
tumors	5.61	7	10754294 (2), 10786686 (1), 10027395 (1), 16618517 (1) (see all 6)
asthma	0	1	16959919 (1)
liver diseases	0	2	17075975 (1)

Human Genome Epidemiology (HuGE) Navigator: CCL19 (4 documents)

Export disorders for CCL19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL19 gene, integrated from 9 sources (see all 173):
(articles sorted by number of sources associating them with CCL19)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PubMed id 9153236)^{1, 2, 3, 9} Yoshida R.... Yoshie O. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Recombinant human CK beta-11/MIP-3 beta/ELC expressed from a mammalian cell system showed potent chemotactic activity for T cells and B cells but not for granulocytes and monocyte. (PubMed id 9498785)^{1, 2} Kim C.H....Broxmeyer H.E. (1998)
Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939)^{1, 2} Rossi D.L.... Zlotnik A. (1997)
Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. (PubMed id 10861057)^{1, 9} Annunziato F....Romagnani S. (2000)
Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. (PubMed id 15019823)^{1, 9} Daikoku N....Honjo H. (2004)
Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. (PubMed id 12474232)^{1, 9} Katou F....Motegi K. (2003)
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. (PubMed id 17825430)^{1, 9} Krumbholz M....Meinl E. (2007)
Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. (PubMed id 10706668)^{1, 9} Gosling J....Schall T.J. (2000)
Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis. (PubMed id 16887149)^{1, 9} Tateyama M....Itoyama Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6363	HGNC: 10617	AceView: CCL19	Ensembl:ENSG00000172724	euGenes: HUgn6363
ECgene: CCL19	Kegg: 6363	H-InvDB: CCL19

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL19	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL19

Intellectual Property for CCL19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCL19 gene:
Search GeneIP for patents involving CCL19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CCL19 Gene

chemokine (C-C motif) ligand 19

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CCL19 (Gene Symbol)
Chemokine (C-C Motif) Ligand 19
ELC
SCYA19
MIP3B
CKb11
MIP-3b
Exodus-3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19
Beta-Chemokine Exodus-3
Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine
Macrophage Inflammatory Protein 3 Beta
Small-Inducible Cytokine A19
MIP-3-Beta
CK Beta-11
EBI1 Ligand Chemokine
Beta Chemokine Exodus-3
C-C Motif Chemokine 19
CC Chemokine Ligand 19
EBI1-Ligand Chemokine
Macrophage Inflammatory Protein 3-Beta

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CCL19 Gene

chemokine (C-C motif) ligand 19

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