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Aliases for CCL19 Gene

Aliases for CCL19 Gene

  • C-C Motif Chemokine Ligand 19 2 3
  • Chemokine (C-C Motif) Ligand 19 2 3 5
  • CK Beta-11 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19 2 3
  • Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine 3 4
  • Macrophage Inflammatory Protein 3-Beta 2 3
  • Macrophage Inflammatory Protein 3 Beta 3 4
  • Small-Inducible Cytokine A19 3 4
  • Beta Chemokine Exodus-3 2 3
  • Beta-Chemokine Exodus-3 3 4
  • CC Chemokine Ligand 19 2 3
  • EBI1-Ligand Chemokine 2 3
  • EBI1 Ligand Chemokine 3 4
  • MIP-3-Beta 3 4
  • SCYA19 3 4
  • MIP3B 3 4
  • ELC 3 4
  • Exodus-3 3
  • MIP-3b 3
  • CKb11 3

External Ids for CCL19 Gene

Previous HGNC Symbols for CCL19 Gene

  • SCYA19

Previous GeneCards Identifiers for CCL19 Gene

  • GC09M035001
  • GC09M034859
  • GC09M034680
  • GC09M034681
  • GC09M034682
  • GC09M034683
  • GC09M034685
  • GC09M034688
  • GC09M034643

Summaries for CCL19 Gene

Entrez Gene Summary for CCL19 Gene

  • This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL19 Gene

CCL19 (C-C Motif Chemokine Ligand 19) is a Protein Coding gene. Diseases associated with CCL19 include Chronic Lymphocytic Leukemia. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include chemokine activity and CCR10 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL19 Gene

  • May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Gene Wiki entry for CCL19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL19 Gene

Genomics for CCL19 Gene

Regulatory Elements for CCL19 Gene

Enhancers for CCL19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL19 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL19 Gene

Chromosome:
9
Start:
34,689,567 bp from pter
End:
34,691,277 bp from pter
Size:
1,711 bases
Orientation:
Minus strand

Genomic View for CCL19 Gene

Genes around CCL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL19 Gene

Proteins for CCL19 Gene

  • Protein details for CCL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99731-CCL19_HUMAN
    Recommended name:
    C-C motif chemokine 19
    Protein Accession:
    Q99731
    Secondary Accessions:
    • O00697
    • O00736

    Protein attributes for CCL19 Gene

    Size:
    98 amino acids
    Molecular mass:
    10993 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL19 Gene

neXtProt entry for CCL19 Gene

Proteomics data for CCL19 Gene at MOPED

Post-translational modifications for CCL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL19 Gene

Domains & Families for CCL19 Gene

Gene Families for CCL19 Gene

Protein Domains for CCL19 Gene

Suggested Antigen Peptide Sequences for CCL19 Gene

Graphical View of Domain Structure for InterPro Entry

Q99731

UniProtKB/Swiss-Prot:

CCL19_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL19: view

Function for CCL19 Gene

Molecular function for CCL19 Gene

UniProtKB/Swiss-Prot Function:
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Gene Ontology (GO) - Molecular Function for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048020 CCR chemokine receptor binding IPI 20002784
genes like me logo Genes that share ontologies with CCL19: view
genes like me logo Genes that share phenotypes with CCL19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL19

miRNA for CCL19 Gene

miRTarBase miRNAs that target CCL19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL19 Gene

Localization for CCL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL19 Gene COMPARTMENTS Subcellular localization image for CCL19 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
plasma membrane 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CCL19 Gene

Pathways & Interactions for CCL19 Gene

genes like me logo Genes that share pathways with CCL19: view

Gene Ontology (GO) - Biological Process for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IDA 12729902
GO:0001771 immunological synapse formation ISS --
GO:0002407 dendritic cell chemotaxis IDA 15778365
GO:0002408 myeloid dendritic cell chemotaxis IDA 14592837
GO:0002548 monocyte chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL19: view

No data available for SIGNOR curated interactions for CCL19 Gene

Drugs & Compounds for CCL19 Gene

(3) Drugs for CCL19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL19: view

Transcripts for CCL19 Gene

mRNA/cDNA for CCL19 Gene

Unigene Clusters for CCL19 Gene

Chemokine (C-C motif) ligand 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL19 Gene

No ASD Table

Relevant External Links for CCL19 Gene

GeneLoc Exon Structure for
CCL19
ECgene alternative splicing isoforms for
CCL19

Expression for CCL19 Gene

mRNA expression in normal human tissues for CCL19 Gene

mRNA differential expression in normal tissues according to GTEx for CCL19 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x15.5) and Artery - Coronary (x5.5).

Protein differential expression in normal tissues from HIPED for CCL19 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCL19 Gene



SOURCE GeneReport for Unigene cluster for CCL19 Gene Hs.50002

mRNA Expression by UniProt/SwissProt for CCL19 Gene

Q99731-CCL19_HUMAN
Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
genes like me logo Genes that share expression patterns with CCL19: view

Protein tissue co-expression partners for CCL19 Gene

Primer Products

Orthologs for CCL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCL19 35
  • 80.9 (n)
  • 73.03 (a)
CCL19 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL19 35
  • 85.32 (n)
  • 83.33 (a)
CCL19 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm2023 35
  • 82.56 (n)
  • 76.74 (a)
Gm2564 16
Ccl19 36
  • 69 (a)
OneToMany
CCL19 36
  • 69 (a)
OneToMany
CR974586.2 36
  • 69 (a)
OneToMany
CR974586.5 36
  • 68 (a)
OneToMany
Gm2564 36
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCL19 35
  • 98.98 (n)
  • 98.98 (a)
CCL19 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl19 35
  • 82.56 (n)
  • 74.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CCL19 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCL19 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccl19 36
  • 28 (a)
OneToMany
CCL19 (1 of 2) 36
  • 29 (a)
OneToMany
Species with no ortholog for CCL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCL19 Gene

ENSEMBL:
Gene Tree for CCL19 (if available)
TreeFam:
Gene Tree for CCL19 (if available)

Paralogs for CCL19 Gene

(12) SIMAP similar genes for CCL19 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL19: view

No data available for Paralogs for CCL19 Gene

Variants for CCL19 Gene

Sequence variations from dbSNP and Humsavar for CCL19 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113701785 -- 34,689,303(+) CTTAG(A/T)GTCGC downstream-variant-500B
rs115247090 -- 34,691,225(+) AGGGC(A/G)ACTGG utr-variant-5-prime
rs2227302 -- 34,689,698(-) CCTGA(C/T)CAGCC utr-variant-3-prime
rs2233870 -- 34,691,932(-) CCAGT(A/C)TCCCT upstream-variant-2KB
rs2233871 -- 34,691,913(-) TCCTT(C/T)GACCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL19 Gene

Variant ID Type Subtype PubMed ID
nsv831544 CNV Gain 17160897
nsv893040 CNV Gain 21882294

Variation tolerance for CCL19 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCL19 Gene

Disorders for CCL19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCL19 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CCL19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL19

Genetic Association Database (GAD)
CCL19
Human Genome Epidemiology (HuGE) Navigator
CCL19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL19
genes like me logo Genes that share disorders with CCL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL19 Gene

Publications for CCL19 Gene

  1. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PMID: 9153236) Yoshida R. … Yoshie O. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. (PMID: 20015995) Nobile C. … Sol-Foulon N. (J. Virol. 2010) 3 23
  3. Chemokine redundancy in BOS pathogenesis. A possible role also for the CC chemokines: MIP3-beta, MIP3-alpha, MDC and their specific receptors. (PMID: 18047937) Meloni F. … Fietta A.M. (Transpl. Immunol. 2008) 3 23
  4. CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. (PMID: 17825430) Krumbholz M. … Meinl E. (J. Neuroimmunol. 2007) 3 23
  5. Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19. (PMID: 16249377) Giordano D. … Clark E.A. (Blood 2006) 3 23

Products for CCL19 Gene

Sources for CCL19 Gene

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