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CCL19 Gene

protein-coding   GIFtS: 59
GCID: GC09M034692

Chemokine (C-C Motif) Ligand 19

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 19)
(Previous symbol: SCYA19)
  See CCL19-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 191 2     Beta-Chemokine Exodus-32 3
SCYA191 2 3 5     Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine2 3
CK Beta-111 2 3     Macrophage Inflammatory Protein 3 Beta2 3
ELC2 3 5     Small-Inducible Cytokine A192 3
MIP3B2 3 5     MIP-3-beta2 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 191 2     EBI1 Ligand Chemokine2 3
Beta Chemokine Exodus-31 2     CKb112
CC Chemokine Ligand 191 2     MIP-3b2
EBI1-Ligand Chemokine1 2     C-C Motif Chemokine 192
Macrophage Inflammatory Protein 3-Beta1 2     exodus-32

External Ids:    HGNC: 106171   Entrez Gene: 63632   Ensembl: ENSG000001727247   OMIM: 6022275   UniProtKB: Q997313   

Export aliases for CCL19 gene to outside databases

Previous GC identifers: GC09M035001 GC09M034859 GC09M034680 GC09M034681 GC09M034682 GC09M034683 GC09M034685 GC09M034688 GC09M034643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL19 Gene:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte
recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and
B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCL19 Gene:
CCL19 (chemokine (C-C motif) ligand 19) is a protein-coding gene. Diseases associated with CCL19 include chronic inflammatory demyelinating polyradiculoneuropathy, and polyradiculoneuropathy. GO annotations related to this gene include CCR7 chemokine receptor binding and chemokine activity.

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte
recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell
migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent
chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine
receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

Gene Wiki entry for CCL19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL19 gene promoter:
         AML1a   p53   SREBP-1c   FOXD1   IRF-1   SREBP-1b   SREBP-1a   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL19 promoter sequence
   Search Chromatin IP Primers for CCL19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

CCL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL19 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034692:  view genomic region     (about GC identifiers)

Start:
34,689,564 bp from pter      End:
34,691,274 bp from pter
Size:
1,711 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731 (See protein sequence)
Recommended Name: C-C motif chemokine 19 precursor  
Size: 98 amino acids; 10993 Da
Secondary accessions: O00697 O00736

Explore the universe of human proteins at neXtProt for CCL19: NX_Q99731

REFSEQ proteins: NP_006265.1  
ENSEMBL proteins: 
 ENSP00000308815   ENSP00000368077  
Reactome Protein details: Q99731

CCL19 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL19 (CCL19/MIP-3 beta)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CCL19
OriGene Custom MassSpec
OriGene Custom Protein Services for CCL19
GenScript Purified and Recombinant Proteins for CCL19
Novus Biologicals CCL19 Proteins
Novus Biologicals CCL19 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for CCL19
Browse Proteins at Cloud-Clone Corp.

 
eBioscience Proteins for CCL19: (see all 2
                    Human CCL19 (MIP-3 beta) Recombinant Protein Carrier-Free 100 ug

 
antibodies-online proteins for CCL19 (51 products) 

 
Search antibodies-online for peptides for CCL19

CCL19 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL19 (CCL19/MIP-3 beta)
OriGene Antibodies for CCL19
OriGene Custom Antibody Services for CCL19
Novus Biologicals CCL19 Antibodies
Abcam antibodies for CCL19 (Q6IBD6, Q99731)
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CCL19
LSBio Antibodies in human, mouse, rat for CCL19
antibodies-online antibodies for CCL19 (61 products) 

CCL19 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL19
R&D Systems Flow Cytometry Kits for CCL19 (CCL19/MIP-3 beta)         (see all)
GenScript Custom Assay Services for CCL19
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CCL19 
antibodies-online kits for CCL19 (37 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q99731

ProtoNet protein and cluster: Q99731

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
Similarity: Belongs to the intercrine beta (chemokine CC) family


Find genes that share domains with CCL19           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL19_HUMAN, Q99731
Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte
recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell
migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent
chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine
receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IDA15778365
GO:0031732CCR7 chemokine receptor binding ISS--
GO:0031735CCR10 chemokine receptor binding IDA10706668
GO:0042379chemokine receptor binding IDA--
GO:0048020CCR chemokine receptor binding IPI--
     
Find genes that share ontologies with CCL19           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl19):
 hematopoietic system  immune system 

Find genes that share phenotypes with CCL19           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL19
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL19

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL19
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL19

miRNA
Products:
    
miRTarBase miRNAs that target CCL19:
hsa-mir-148b-3p (MIRT019331), hsa-mir-9-5p (MIRT021321), hsa-mir-335-5p (MIRT018017)

Block miRNA regulation of human, mouse, rat CCL19 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CCL19:
hsa-miR-2355-5p hsa-miR-342-3p
SwitchGear 3'UTR luciferase reporter plasmidCCL19 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CCL19
Predesigned siRNA for gene silencing in human, mouse, rat CCL19

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL19

Clone
Products:
     
OriGene clones in human, mouse for CCL19 (see all 6)
OriGene ORF clones in mouse, rat for CCL19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL19 (NM_006274)
Sino Biological Human cDNA Clone for CCL19
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL19
Addgene plasmids for CCL19 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCL19
Browse ESI BIO Cell Lines and PureStem Progenitors for CCL19 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL19


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CCL19_HUMAN, Q99731: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton1
nucleus1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CCL19           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCL19 About   (see all 12)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3LT-BetaR Pathway
Apoptosis and survival Lymphotoxin beta receptor signaling0.46
LT-BetaR Pathway0.46
4Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
5TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40


Find genes that share SuperPaths with CCL19           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCL19
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL19 (see all 28)
    LT-BetaR Pathway
Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions

1 GeneGo (Thomson Reuters) Pathway for CCL19
    Apoptosis and survival Lymphotoxin-beta receptor signaling


2 Reactome Pathways for CCL19
    Chemokine receptors bind chemokines
G alpha (i) signalling events


3 Kegg Pathways  (Kegg details for CCL19):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NF-kappa B signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL19 (see all 6): 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CCL19

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCL19 (Q997313 ENSP000003088154) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
InteractantInteraction Details
GeneCardExternal ID(s)
CCR7P322483, ENSP000002466574I2D: score=5 STRING: ENSP00000246657
CCR10P460923, ENSP000003325044I2D: score=3 STRING: ENSP00000332504
ACKR2O005903, ENSP000002731454I2D: score=2 STRING: ENSP00000273145
CXCL13O439273, ENSP000002867584I2D: score=2 STRING: ENSP00000286758
ACKR4Q9NPB93, ENSP000002498874I2D: score=3 STRING: ENSP00000249887
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Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001768establishment of T cell polarity IDA12729902
GO:0001771immunological synapse formation ISS--
GO:0002407dendritic cell chemotaxis IDA15778365
GO:0002408myeloid dendritic cell chemotaxis IDA14592837
GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--

Find genes that share ontologies with CCL19           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCL19

Selected Novoseek inferred chemical compound relationships for CCL19 gene (see all 11)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
mip-3beta 85.6 3 12437666 (1), 15142882 (1)
larc 80.9 8 9365118 (3), 10027395 (2), 10934220 (1), 10967023 (1)
tarc 77.1 10 9365118 (3), 11358988 (2), 15890946 (2), 11154210 (1)
ccl3 70.9 6 15256380 (2), 20015995 (1), 15784733 (1), 19726994 (1) (see all 5)
peg-10 69.6 3 16225771 (2)
teck 69.1 4 10706668 (3), 10967023 (1)
rantes 65.5 5 10559506 (1), 11160268 (1), 14512544 (1), 15233729 (1) (see all 5)
calcium 16.6 6 9507024 (2), 12351815 (1), 10201891 (1), 19012040 (1)
pge2 14.2 4 12149218 (1)
dextran 10 2 14742992 (1), 14512544 (1)



Find genes that share compounds with CCL19           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCL19 gene: 
NM_006274.2  

Unigene Cluster for CCL19:

Chemokine (C-C motif) ligand 19
Hs.50002  [show with all ESTs]
Unigene Representative Sequence: BI521023
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000311925(uc003zvn.3 uc010mkf.3) ENST00000485502 ENST00000378800

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CCL19 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CCL19:
hsa-miR-2355-5p hsa-miR-342-3p
SwitchGear 3'UTR luciferase reporter plasmidCCL19 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CCL19
Predesigned siRNA for gene silencing in human, mouse, rat CCL19
Clone
Products:
     
OriGene clones in human, mouse for CCL19 (see all 6)
OriGene ORF clones in mouse, rat for CCL19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL19 (NM_006274)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL19
Addgene plasmids for CCL19 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CCL19
OriGene qSTAR qPCR primer pairs in human, mouse for CCL19
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL19
  QuantiTect SYBR Green Assays in human, mouse, rat CCL19
  QuantiFast Probe-based Assays in human, mouse, rat CCL19

Additional mRNA sequence: 

AB000887.1 AK311945.1 BC027968.1 CR456868.1 U77180.1 U88321.1 

3 DOTS entries:

DT.412582  DT.121194064  DT.92005478 

Selected AceView cDNA sequences (see all 84):

BI837646 BF001364 AI096411 CR456868 BM768365 AI718724 BM720436 NM_006274 
AV727235 BX105269 AI707962 AI719120 AB000887 BQ005590 N80273 CD696746 
BC027968 CR623730 W07401 AI719843 CD689032 AI581755 BI521023 BM688801 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCL19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCTGCTAC
CCL19 Expression
About this image


CCL19 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 11) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Visceral White Adipocytes Visceral White Adipose
         Body Subcutaneous White Adipose
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone marrow-derived mesenchymal stem cells
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Epithelial Cells
         Outer Root Sheath Cells Outer Root Sheath
CCL19 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.50002

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in
colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL19 (see all 6): 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CCL19
OriGene qSTAR qPCR primer pairs in human, mouse for CCL19
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL19
QuantiTect SYBR Green Assays in human, mouse, rat CCL19
QuantiFast Probe-based Assays in human, mouse, rat CCL19
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL19

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCL19 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccl195
Gm20231
chemokine (C-C motif) ligand 195
predicted gene 20231
82.56(n)1
76.74(a)1
  4 (22.80 cM)5
1000390531  XM_001472168.41  XP_001472218.11 
 427545255 
chicken
(Gallus gallus)
Aves CCL196
chemokine (C-C motif) ligand 19
40(a)
1 ↔ 1
Z(8222635-8225085)
zebrafish
(Danio rerio)
Actinopterygii CCL19 (1 of 2)6
ccl196
chemokine (C-C motif) ligand 19
29(a)
28(a)
many → 1
many → 1
5(14575941-14578542) ENSDARG00000035632
10(17807201-17810322) ENSDARG00000039351


ENSEMBL Gene Tree for CCL19 (if available)
TreeFam Gene Tree for CCL19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCL19 gene
12 SIMAP similar genes for CCL19 using alignment to 3 protein entries:     CCL19_HUMAN (see all proteins):
CCL16    CCL26    CCL21    CCL22    CCL3    CCL5
CCL15    CCL24    CCL4    CCL17    CCL3L1    CCL3L3

Find genes that share paralogs with CCL19           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCL19 (see all 96)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1458444781,2
C--34689266(+) TGAGAC/TGCTGG 1 -- ds50010--------
rs1452426021,2
--34689470(+) GACAGA/CTCTAT 1 -- ds50010--------
rs1491736611,2
--34689515(+) TAGTTA/CAGCAG 1 -- ds50010--------
rs22273021,2
C,F,H--34689695(-) CCTGAC/TCAGCC 1 -- ut31 ese315Minor allele frequency- T:0.05MN NS EA NA 1670
rs1432260481,2
C--34689724(+) GAAGCC/TTGGTC 1 -- ut310--------
rs1482920701,2
C,F--34689791(+) GACTCC/TGGGCT 1 -- ut311Minor allele frequency- T:0.00EU 1071
rs22338771,2
C,H--34689792(-) GAGCCC/TGGAGT 1 -- ut314Minor allele frequency- T:0.00NS EA 420
rs2003489341,2
C,F--34689801(+) TCCCTC/TTGCAC 1 -- ut311Minor allele frequency- T:0.00EU 1111
rs1921425821,2
C--34689815(+) CATAGC/GTTAAC 1 -- ut310--------
rs1462559991,2
C,F--34689830(+) GCGGCG/ACTTCA 2 /R /C mis11Minor allele frequency- A:0.00NA 4552

HapMap Linkage Disequilibrium report for CCL19 (34689564 - 34691274 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CCL19:    About this table    
Variant IDTypeSubtypePubMed ID
nsv893040CNV Gain21882294
nsv831544CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602227    OMIM disorders: --

2 diseases for CCL19:    
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chronic inflammatory demyelinating polyradiculoneuropathy    polyradiculoneuropathy


Find genes that share disorders with CCL19           About GenesLikeMe

Selected Novoseek inferred disease relationships for CCL19 gene (see all 14)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
b-all 44.4 3 16225771 (3)
inflammation 34.7 4 16118351 (1), 19747210 (1), 16618517 (1)
leukemia lymphocytic chronic 32.2 1 17082584 (1)
autoimmune diseases 27.8 1 16887149 (1)
necrosis 23.3 5 12949243 (1), 10027395 (1), 16282532 (1), 11298554 (1) (see all 5)
lymphadenopathy 17.1 1 11929789 (1)
atherosclerotic plaque 15.1 2 10027395 (2)
tumors 5.61 7 10754294 (2), 10786686 (1), 10027395 (1), 16618517 (1) (see all 6)
asthma 0 1 16959919 (1)
liver diseases 0 2 17075975 (1)

Genetic Association Database (GAD): CCL19
Human Genome Epidemiology (HuGE) Navigator: CCL19 (4 documents)

Export disorders for CCL19 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCL19 gene, integrated from 10 sources (see all 178):
(articles sorted by number of sources associating them with CCL19)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PubMed id 9153236)1, 2, 3, 9 Yoshida R.... Yoshie O. (J. Biol. Chem. 1997)
  2. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  3. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. (PubMed id 9498785)1, 2 Kim C.H....Broxmeyer H.E. (J. Immunol. 1998)
  7. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939)1, 2 Rossi D.L.... Zlotnik A. (J. Immunol. 1997)
  8. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. (PubMed id 10861057)1, 9 Annunziato F....Romagnani S. (J. Immunol. 2000)
  9. Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. (PubMed id 15019823)1, 9 Daikoku N....Honjo H. (Fertil. Steril. 2004)
  10. Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. (PubMed id 12474232)1, 9 Katou F....Motegi K. (J. Pathol. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6363 HGNC: 10617 AceView: CCL19 Ensembl:ENSG00000172724 euGenes: HUgn6363
ECgene: CCL19 Kegg: 6363 H-InvDB: CCL19

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCL19 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL19

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCL19 gene:
Search GeneIP for patents involving CCL19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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