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Aliases for CCL19 Gene

Aliases for CCL19 Gene

  • Chemokine (C-C Motif) Ligand 19 2 3
  • CK Beta-11 2 3 4
  • SCYA19 3 4 6
  • MIP3B 3 4 6
  • ELC 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19 2 3
  • Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine 3 4
  • Macrophage Inflammatory Protein 3-Beta 2 3
  • Macrophage Inflammatory Protein 3 Beta 3 4
  • Small-Inducible Cytokine A19 3 4
  • Beta Chemokine Exodus-3 2 3
  • Beta-Chemokine Exodus-3 3 4
  • CC Chemokine Ligand 19 2 3
  • EBI1-Ligand Chemokine 2 3
  • EBI1 Ligand Chemokine 3 4
  • MIP-3-Beta 3 4
  • C-C Motif Chemokine 19 3
  • Exodus-3 3
  • MIP-3b 3
  • CKb11 3

External Ids for CCL19 Gene

Previous HGNC Symbols for CCL19 Gene

  • SCYA19

Previous GeneCards Identifiers for CCL19 Gene

  • GC09M035001
  • GC09M034859
  • GC09M034680
  • GC09M034681
  • GC09M034682
  • GC09M034683
  • GC09M034685
  • GC09M034688
  • GC09M034643

Summaries for CCL19 Gene

Entrez Gene Summary for CCL19 Gene

  • This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL19 Gene

CCL19 (Chemokine (C-C Motif) Ligand 19) is a Protein Coding gene. Diseases associated with CCL19 include chronic inflammatory demyelinating polyradiculoneuropathy and polyradiculoneuropathy. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity and CCR7 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL19 Gene

  • May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Gene Wiki entry for CCL19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL19 Gene

Genomics for CCL19 Gene

Regulatory Elements for CCL19 Gene

Genomic Location for CCL19 Gene

Start:
34,689,567 bp from pter
End:
34,691,277 bp from pter
Size:
1,711 bases
Orientation:
Minus strand

Genomic View for CCL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL19 Gene

Proteins for CCL19 Gene

  • Protein details for CCL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99731-CCL19_HUMAN
    Recommended name:
    C-C motif chemokine 19
    Protein Accession:
    Q99731
    Secondary Accessions:
    • O00697
    • O00736

    Protein attributes for CCL19 Gene

    Size:
    98 amino acids
    Molecular mass:
    10993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL19 Gene

Proteomics data for CCL19 Gene at MOPED

Post-translational modifications for CCL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL19 (CCL19/MIP-3 beta)

Protein Products

No data available for DME Specific Peptides for CCL19 Gene

Domains for CCL19 Gene

Gene Families for CCL19 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL19 Gene

Suggested Antigen Peptide Sequences for CCL19 Gene

Graphical View of Domain Structure for InterPro Entry

Q99731

UniProtKB/Swiss-Prot:

CCL19_HUMAN :
  • Q99731
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL19: view

Function for CCL19 Gene

Molecular function for CCL19 Gene

UniProtKB/Swiss-Prot Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Gene Ontology (GO) - Molecular Function for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 15778365
GO:0031732 CCR7 chemokine receptor binding ISS --
GO:0031735 CCR10 chemokine receptor binding IDA 10706668
GO:0042379 chemokine receptor binding IDA 23341447
GO:0048020 CCR chemokine receptor binding IPI 20002784
genes like me logo Genes that share ontologies with CCL19: view

Phenotypes for CCL19 Gene

genes like me logo Genes that share phenotypes with CCL19: view

Animal Model Products

CRISPR Products

miRNA for CCL19 Gene

miRTarBase miRNAs that target CCL19

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL19 Gene

Localization for CCL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL19 Gene COMPARTMENTS Subcellular localization image for CCL19 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL19: view

Pathways for CCL19 Gene

genes like me logo Genes that share pathways with CCL19: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IDA 12729902
GO:0001771 immunological synapse formation ISS --
GO:0002407 dendritic cell chemotaxis IDA 15778365
GO:0002408 myeloid dendritic cell chemotaxis IDA 14592837
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
genes like me logo Genes that share ontologies with CCL19: view

Compounds for CCL19 Gene

(11) Novoseek inferred chemical compound relationships for CCL19 Gene

Compound -log(P) Hits PubMed IDs
mip-3beta 85.6 2
larc 80.9 7
tarc 77.1 8
ccl3 70.9 6
peg-10 69.6 2
genes like me logo Genes that share compounds with CCL19: view

Transcripts for CCL19 Gene

mRNA/cDNA for CCL19 Gene

Unigene Clusters for CCL19 Gene

Chemokine (C-C motif) ligand 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL19 Gene

No ASD Table

Relevant External Links for CCL19 Gene

GeneLoc Exon Structure for
CCL19
ECgene alternative splicing isoforms for
CCL19

Expression for CCL19 Gene

mRNA expression in normal human tissues for CCL19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL19 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (15.5) and Artery - Coronary (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCL19 Gene

SOURCE GeneReport for Unigene cluster for CCL19 Gene Hs.50002

mRNA Expression by UniProt/SwissProt for CCL19 Gene

Q99731-CCL19_HUMAN
Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach
genes like me logo Genes that share expressions with CCL19: view

In Situ Assay Products

Orthologs for CCL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL19 35
  • 98.98 (n)
  • 98.98 (a)
CCL19 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL19 35
  • 80.9 (n)
  • 73.03 (a)
CCL19 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL19 35
  • 85.32 (n)
  • 83.33 (a)
CCL19 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl19 16
Ccl19 36
  • 69 (a)
OneToMany
CCL19 36
  • 69 (a)
OneToMany
CR974586.2 36
  • 69 (a)
OneToMany
CR974586.5 36
  • 68 (a)
OneToMany
Gm2023 35
  • 82.56 (n)
  • 76.74 (a)
Gm2564 36
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCL19 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl19 35
  • 82.56 (n)
  • 74.42 (a)
chicken
(Gallus gallus)
Aves CCL19 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccl19 36
  • 28 (a)
OneToMany
CCL19 (1 of 2) 36
  • 29 (a)
OneToMany
Species with no ortholog for CCL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCL19 Gene

ENSEMBL:
Gene Tree for CCL19 (if available)
TreeFam:
Gene Tree for CCL19 (if available)

Paralogs for CCL19 Gene

Selected SIMAP similar genes for CCL19 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCL19: view

No data available for Paralogs for CCL19 Gene

Variants for CCL19 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL19 Gene

Variant ID Type Subtype PubMed ID
nsv831544 CNV Gain 17160897
nsv893040 CNV Gain 21882294

Relevant External Links for CCL19 Gene

HapMap Linkage Disequilibrium report
CCL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CCL19 Gene

Disorders for CCL19 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCL19 Gene including...

Search for CCL19 Gene in MalaCards »

(14) Novoseek inferred disease relationships for CCL19 Gene

Disease -log(P) Hits PubMed IDs
b-all 44.4 3
inflammation 34.7 3
leukemia lymphocytic chronic 32.2 1
autoimmune diseases 27.8 1
necrosis 23.3 5

Relevant External Links for CCL19

Genetic Association Database (GAD)
CCL19
Human Genome Epidemiology (HuGE) Navigator
CCL19
genes like me logo Genes that share disorders with CCL19: view

No data available for UniProtKB/Swiss-Prot for CCL19 Gene

Publications for CCL19 Gene

  1. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PMID: 9153236) Yoshida R. … Yoshie O. (J. Biol. Chem. 1997) 2 3 4 23
  2. Molecular cloning of a novel human CC chemokine secondary lymphoid- tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. (PMID: 9235955) Nagira M. … Yoshie O. (J. Biol. Chem. 1997) 3 23
  3. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. (PMID: 10861057) Annunziato F. … Romagnani S. (J. Immunol. 2000) 3 23
  4. The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. (PMID: 11929789) Till K.J. … Cawley J.C. (Blood 2002) 3 23
  5. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. (PMID: 12729902) Bardi G. … Loetscher P. (FEBS Lett. 2003) 3 23

Products for CCL19 Gene

  • Addgene plasmids for CCL19

Sources for CCL19 Gene

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