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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL19 Gene

protein-coding   GIFtS: 60
GCID: GC09M034692

Chemokine (C-C Motif) Ligand 19

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 19)
(Previous symbol: SCYA19)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 191 2     Beta-Chemokine Exodus-32 3
SCYA191 2 3 5     Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine2 3
CK Beta-111 2 3     Macrophage Inflammatory Protein 3 Beta2 3
ELC2 3 5     Small-Inducible Cytokine A192 3
MIP3B2 3 5     MIP-3-beta2 3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 191 2     EBI1 Ligand Chemokine2 3
Beta Chemokine Exodus-31 2     CKb112
CC Chemokine Ligand 191 2     MIP-3b2
EBI1-Ligand Chemokine1 2     C-C Motif Chemokine 192
Macrophage Inflammatory Protein 3-Beta1 2     exodus-32

External Ids:    HGNC: 106171   Entrez Gene: 63632   Ensembl: ENSG000001727247   OMIM: 6022275   UniProtKB: Q997313   

Export aliases for CCL19 gene to outside databases

Previous GC identifers: GC09M035001 GC09M034859 GC09M034680 GC09M034681 GC09M034682 GC09M034683 GC09M034685 GC09M034688 GC09M034643


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL19 Gene:
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte
recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and
B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCL19 Gene: 
CCL19 (chemokine (C-C motif) ligand 19) is a protein-coding gene. Diseases associated with CCL19 include chronic inflammatory demyelinating polyradiculoneuropathy, and klebsiella, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and LT-BetaR Pathway. GO annotations related to this gene include CCR7 chemokine receptor binding and chemokine activity.

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte
recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell
migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows
potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes

Gene Wiki entry for CCL19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL19 gene promoter:
         AML1a   p53   SREBP-1c   FOXD1   IRF-1   SREBP-1b   SREBP-1a   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL19 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

CCL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL19 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034692:  view genomic region     (about GC identifiers)

Start:
34,689,564 bp from pter      End:
34,691,274 bp from pter
Size:
1,711 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731 (See protein sequence)
Recommended Name: C-C motif chemokine 19 precursor  
Size: 98 amino acids; 10993 Da
Subcellular location: Secreted
Secondary accessions: O00697 O00736

Explore the universe of human proteins at neXtProt for CCL19: NX_Q99731

Explore proteomics data for CCL19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99731

  • CCL19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL19 Protein Expression
    REFSEQ proteins: NP_006265.1  
    ENSEMBL proteins: 
     ENSP00000308815   ENSP00000368077  
    Reactome Protein details: Q99731
    Human Recombinant Protein Products for CCL19: 
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    GenScript Purified and Recombinant Proteins for CCL19
    Novus Biologicals CCL19 Proteins
    Novus Biologicals CCL19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL19
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL19 for ontologies           About GeneDecksing



    CCL19 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99731

    ProtoNet protein and cluster: Q99731

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL19_HUMAN, Q99731
    Function: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte
    recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell
    migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows
    potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IDA15778365
    GO:0031732CCR7 chemokine receptor binding ISS--
    GO:0031735CCR10 chemokine receptor binding IDA10706668
    GO:0048020CCR chemokine receptor binding IPI--
         
    CCL19 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl19):
     hematopoietic system  immune system 

    CCL19 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL19 

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    SwitchGear 3'UTR luciferase reporter plasmidCCL19 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCL19

    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL19 (NM_006274)
    Sino Biological Human cDNA Clone for CCL19
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                         Customized lentivirus expression plasmids for stable overexpression of CCL19 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL19 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL19
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL19 (see all 28)
        LT-BetaR Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions

    1 GeneGo (Thomson Reuters) Pathway for CCL19
        Apoptosis and survival Lymphotoxin-beta receptor signaling


    5/8        Reactome Pathways for CCL19 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCL19):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway


    CCL19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for CCL19 (Q997313 ENSP000003088154) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR7P322483, ENSP000002466574I2D: score=5 STRING: ENSP00000246657
    CCR10P460923, ENSP000003325044I2D: score=3 STRING: ENSP00000332504
    ACKR2O005903, ENSP000002731454I2D: score=2 STRING: ENSP00000273145
    CXCL13O439273, ENSP000002867584I2D: score=2 STRING: ENSP00000286758
    ACKR4Q9NPB93, ENSP000002498874I2D: score=3 STRING: ENSP00000249887
    About this table

    Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001768establishment of T cell polarity IDA12729902
    GO:0001771immunological synapse formation ISS--
    GO:0002407dendritic cell chemotaxis IDA15778365
    GO:0002408myeloid dendritic cell chemotaxis IDA14592837
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--

    CCL19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL19 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL19

    10/11 Novoseek inferred chemical compound relationships for CCL19 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mip-3beta 85.6 3 12437666 (1), 15142882 (1)
    larc 80.9 8 9365118 (3), 10027395 (2), 10934220 (1), 10967023 (1)
    tarc 77.1 10 9365118 (3), 11358988 (2), 15890946 (2), 11154210 (1)
    ccl3 70.9 6 15256380 (2), 20015995 (1), 15784733 (1), 19726994 (1) (see all 5)
    peg-10 69.6 3 16225771 (2)
    teck 69.1 4 10706668 (3), 10967023 (1)
    rantes 65.5 5 10559506 (1), 11160268 (1), 14512544 (1), 15233729 (1) (see all 5)
    calcium 16.6 6 9507024 (2), 12351815 (1), 10201891 (1), 19012040 (1)
    pge2 14.2 4 12149218 (1)
    dextran 10 2 14742992 (1), 14512544 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL19 gene: 
    NM_006274.2  

    Unigene Cluster for CCL19:

    Chemokine (C-C motif) ligand 19
    Hs.50002  [show with all ESTs]
    Unigene Representative Sequence: BI521023
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311925(uc003zvn.3 uc010mkf.3) ENST00000485502 ENST00000378800

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL19
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL19:
    hsa-miR-2355-5p hsa-miR-342-3p
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL19

    Additional mRNA sequence: 

    AB000887.1 AK311945.1 BC027968.1 CR456868.1 U77180.1 U88321.1 

    3 DOTS entries:

    DT.412582  DT.121194064  DT.92005478 

    24/84 AceView cDNA sequences (see all 84):

    NM_006274 BX105269 BC027968 AI096411 CR623730 AV727235 CD696746 BI837646 
    AI719120 AI718724 BQ005590 N80273 AB000887 CR456868 BM768365 AI707962 
    W07401 BM720436 BF001364 AA680186 AI719843 AI660682 D31431 AI880647 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL19 expression in normal human tissues (normalized intensities)      CCL19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGCTAC
    CCL19 Expression
    About this image


    CCL19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             Lymphnode   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus   
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells

    See CCL19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL19

    SOURCE GeneReport for Unigene cluster: Hs.50002

    UniProtKB/Swiss-Prot: CCL19_HUMAN, Q99731
    Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in
    colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL19 (see all 6): 
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL19 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl195
    Gm20231
    chemokine (C-C motif) ligand 195
    predicted gene 20231
    83.51(n)1
    77.89(a)1
      4 (22.80 cM)5
    1000390531  XM_001472168.31  XP_001472218.11 
     427545255 
    chicken
    (Gallus gallus)
    Aves CCL196
    Uncharacterized protein
    41(a)
    1 → many
    Z(8222635-8225085)


    ENSEMBL Gene Tree for CCL19 (if available)
    TreeFam Gene Tree for CCL19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL19 gene
    12 SIMAP similar genes for CCL19 using alignment to 3 protein entries:     CCL19_HUMAN (see all proteins):
    CCL16    CCL26    CCL21    CCL22    CCL3    CCL5
    CCL15    CCL24    CCL4    CCL17    CCL3L1    CCL3L3

    CCL19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 SNPs in CCL19 are shown (see all 96)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458444781,2
    C--34689266(+) TGAGAC/TGCTGG 1 -- ds50010--------
    rs1452426021,2
    --34689470(+) GACAGA/CTCTAT 1 -- ds50010--------
    rs1491736611,2
    --34689515(+) TAGTTA/CAGCAG 1 -- ds50010--------
    rs22273021,2
    C,F,H--34689695(-) CCTGAC/TCAGCC 1 -- ut31 ese315Minor allele frequency- T:0.05MN NS EA NA 1670
    rs1432260481,2
    C--34689724(+) GAAGCC/TTGGTC 1 -- ut310--------
    rs1482920701,2
    C,F--34689791(+) GACTCC/TGGGCT 1 -- ut311Minor allele frequency- T:0.00EU 1071
    rs22338771,2
    C,H--34689792(-) GAGCCC/TGGAGT 1 -- ut314Minor allele frequency- T:0.00NS EA 420
    rs2003489341,2
    C,F--34689801(+) TCCCTC/TTGCAC 1 -- ut311Minor allele frequency- T:0.00EU 1111
    rs1921425821,2
    C--34689815(+) CATAGC/GTTAAC 1 -- ut310--------
    rs1462559991,2
    C,F--34689830(+) GCGGCG/ACTTCA 2 /R /C mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for CCL19 (34689564 - 34691274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL19:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893040CNV Gain21882294
    nsv831544CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602227    OMIM disorders: --

    20/43 diseases for CCL19 (see all 43):    About MalaCards
    chronic inflammatory demyelinating polyradiculoneuropathy    klebsiella    central nervous system lymphoma    polyradiculoneuropathy
    allergic contact dermatitis    contact dermatitis    peripheral t-cell lymphoma    inclusion body myositis
    guillain-barre syndrome    common variable immunodeficiency    myositis    acute lymphocytic leukemia
    adult t-cell leukemia    mantle cell lymphoma    liver disease    fatty liver disease
    polymyositis    chronic lymphocytic leukemia    dermatomyositis    pertussis


    CCL19 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for CCL19 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b-all 44.4 3 16225771 (3)
    inflammation 34.7 4 16118351 (1), 19747210 (1), 16618517 (1)
    leukemia lymphocytic chronic 32.2 1 17082584 (1)
    autoimmune diseases 27.8 1 16887149 (1)
    necrosis 23.3 5 12949243 (1), 10027395 (1), 16282532 (1), 11298554 (1) (see all 5)
    lymphadenopathy 17.1 1 11929789 (1)
    atherosclerotic plaque 15.1 2 10027395 (2)
    tumors 5.61 7 10754294 (2), 10786686 (1), 10027395 (1), 16618517 (1) (see all 6)
    asthma 0 1 16959919 (1)
    liver diseases 0 2 17075975 (1)

    Genetic Association Database (GAD): CCL19
    Human Genome Epidemiology (HuGE) Navigator: CCL19 (4 documents)

    Export disorders for CCL19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL19 gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with CCL19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PubMed id 9153236)1, 2, 3, 9 Yoshida R.... Yoshie O. (1997)
    2. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    3. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Recombinant human CK beta-11/MIP-3 beta/ELC expressed from a mammalian cell system showed potent chemotactic activity for T cells and B cells but not for granulocytes and monocyte. (PubMed id 9498785)1, 2 Kim C.H....Broxmeyer H.E. (1998)
    7. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. (PubMed id 9013939)1, 2 Rossi D.L.... Zlotnik A. (1997)
    8. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. (PubMed id 10861057)1, 9 Annunziato F....Romagnani S. (2000)
    9. Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. (PubMed id 15019823)1, 9 Daikoku N....Honjo H. (2004)
    10. Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin. (PubMed id 12474232)1, 9 Katou F....Motegi K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6363 HGNC: 10617 AceView: CCL19 Ensembl:ENSG00000172724 euGenes: HUgn6363
    ECgene: CCL19 Kegg: 6363 H-InvDB: CCL19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL19 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL19

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL19 gene:
    Search GeneIP for patents involving CCL19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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