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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL18 Gene

protein-coding   GIFtS: 55
GCID: GC17P034391

chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA18)
 Explore 55 diseases affiliated with
CCL18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL18    

Aliases
for CCL18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)1 2     Dendritic Cell Chemokine 12 3
DCCK11 2 3 5     Macrophage Inflammatory Protein 42 3
PARC1 2 3 5     Pulmonary And Activation-Regulated Chemokine2 3
SCYA181 2 3 5     Small-Inducible Cytokine A182 3
AMAC-11 2 3     CC Chemokine PARC2 3
DC-CK11 2 3     C-C Motif Chemokine 182
MIP-41 2 3     CC Chemokine Ligand 182
AMAC12 3 5     Chemokine (C-C), Dendritic2
CKb71 2     Small Inducible Cytokine A182
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And
Activation-Regulated1 2
     MIP43
Alternative Macrophage Activation-Associated CC Chemokine 12 3     

External Ids:    HGNC: 106161   Entrez Gene: 63622   Ensembl: ENSG000000060747   OMIM: 6037575   UniProtKB: P557743   

Export aliases for CCL18 gene to outside databases

Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576


Summaries
for CCL18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL18:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family
of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T
cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine
attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in
both humoral and cell-mediated immunity responses. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell
migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated
macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role
in both humoral and cell-mediated immunity responses




Genomic Views
for CCL18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL18 gene promoter:
         POU2F2 (Oct-2.1)   TBP   AML1a   p53   POU2F2   YY1   POU2F2C   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL18 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

Start:
 34,391,640 bp from pter      End:
 34,399,392 bp from pter
Size:
 7,753 bases      Orientation:
 plus strand

Proteins
for CCL18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774 (See protein sequence)
Recommended Name: C-C motif chemokine 18 precursor  
Size: 89 amino acids; 9849 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396;
Secondary accessions: B5BUM2 Q53X71

Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

CCL18 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_002979.1  
ENSEMBL proteins: 
 ENSP00000004921  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL18 (CCL18/PARC)
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OriGene Purified Protein: CCL18
OriGene Protein Over-expression Lysate: CCL18
OriGene Custom Protein Services for CCL18 
GenScript Purified and Recombinant Proteins for CCL18
Novus Biologicals CCL18 Proteins
Novus Biologicals CCL18 Lysate
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for CCL18
Uscn Proteins for CCL18

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--


CCL18 for ontologies           About GeneDecksing



CCL18 Antibody Products: 
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Novus Biologicals CCL18 Antibodies
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Uscn Antibodies for CCL18
Search ThermoFisher Antibodies for CCL18

Assay Products for CCL18: 
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R&D Systems ELISAs for CCL18 (CCL18/PARC)         (see all)
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Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CCL18

Protein Domains /
Families
for CCL18 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
CCL18 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P55774

ProtoNet protein and cluster: P55774

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Similarity: Belongs to the intercrine beta (chemokine CC) family


Function
for CCL18 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell
migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated
macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role
in both humoral and cell-mediated immunity responses
Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10.
Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in
combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by
phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmid: CCL18 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL18
OriGene shRNA RFP: CCL18
OriGene siRNA: CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for CCL18

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL18
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
Sino Biological Human cDNA Clone for CCL18
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for CCL18
Search LifeMap BioReagents cell lines for CCL18

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0008009chemokine activity IEA--


CCL18 for ontologies           About GeneDecksing



Pathways & Interactions
for CCL18 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1PEDF Induced Signaling
8/12 pathways (see all 12)
PEDF Induced Signaling1.00
STAT3 Pathway0.47
MIF Mediated Glucocorticoid Regulation0.73
Endothelin-1 Signaling Pathway0.44
MIF Regulation of Innate Immune Cells0.71
NFAT Signaling and Lymphocyte Interactions0.37
IL-6 Pathway0.61
PGC1Alpha Pathway0.33
2TGF-Beta Pathway
TGF-Beta Pathway1.00
JNK Pathway0.50
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.29
3Akt Signaling
Akt Signaling1.00
Tec Kinases Signaling0.55
p38 Signaling0.60
4Rho Family GTPases
Rho Family GTPases1.00
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5PAK Pathway
PAK Pathway1.00
Antioxidant Action of Vitamin-C0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL18 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway


2         Kegg Pathways  (Kegg details for CCL18):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway


CCL18 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCL18

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/31 Interacting proteins for CCL18 (P557741, 2, 3 ENSP000000049214) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
InteractantInteraction Details
GeneCardExternal ID(s)
C14orf1Q9UKR52, 3MINT-63888 I2D: score=6 
TP53P046372, 3MINT-63883 I2D: score=6 
UNC119Q134322, 3MINT-63885 I2D: score=6 
CRMP1Q141942, 3MINT-63886 I2D: score=5 
TLE1Q047242, 3MINT-63884 I2D: score=5 
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007154cell communication TAS9192897
GO:0007165signal transduction TAS9233607


CCL18 for ontologies           About GeneDecksing



Drugs & Compounds
for CCL18 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL18 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL18
10 Novoseek chemical compound relationships for CCL18 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 79.7 9 9365118 (2), 11358988 (2), 11159181 (1), 18086588 (1) (see all 6)
larc 75.2 6 9365118 (2), 10027395 (2), 12239608 (1)
ccl3 71 5 16773571 (2), 17369706 (1), 15588486 (1)
rantes 54.8 9 10744077 (4), 17909104 (2), 10559506 (1), 11576227 (1) (see all 5)
ofloxacin 25.8 2 12878509 (1), 19745030 (1)
ccl4 18.3 3 16773571 (2), 17369706 (1)
vegf 3.95 2 16671879 (1), 17082335 (1)
calcium 0 2 10087196 (1), 16601239 (1)
alanine 0 1 10744077 (1)
dexamethasone 0 3 12161279 (2), 12673080 (1)

Search CenterWatch for drugs/clinical trials and news about CCL18 

Transcripts
for CCL18 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for CCL18 gene: 
NM_002988.2  

Unigene Cluster for CCL18:

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Hs.143961  [show with all ESTs]
Unigene Representative Sequence: Y13710
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000004921(uc002hku.3) ENST00000586857

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmid: CCL18 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL18
OriGene shRNA RFP: CCL18
OriGene siRNA: CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL18
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL18
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18

Additional cDNA sequence: 

AB000221.1 AB451458.1 BC069700.1 BC096124.3 BC096125.3 BC096126.1 BC096127.1 CR407660.1 
Y13710.1 

2 DOTS entries:

DT.314426  DT.100748759 

24/73 AceView cDNA sequences (see all 73):

CA440845 NM_002988 AA729801 CA435401 BM991019 CR407660 BX116770 AW264712 
AA425047 BQ025756 AA296912 AB000221 N44551 Y13710 AI274247 BC069700 
AW662706 BU617136 CA428280 CA428234 AA031820 AW269476 BU617575 AI969253 

GeneLoc Exon Structure


Expression
for CCL18 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCAATCAG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See CCL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL18

SOURCE GeneReport for Unigene cluster: Hs.143961

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in
germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood
monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite
for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian
carcinoma ascitic fluid

    SABiosciences Expression via Pathway-Focused PCR Arrays including CCL18: 
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

Orthologs
for CCL18 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for CCL18 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii zgc:1937066
si:dkeyp-59a8.36
(see all 6)		 si:dkeyp-59a8.3
(see all 6)		 32(a)
26(a)
(see all 6)		 many ↔ many
many ↔ many
(see all 6)		 25(25902180-25904281)
20(38310380-38311158)


ENSEMBL Gene Tree for CCL18 (if available)
TreeFam Gene Tree for CCL18 (if available) 

Paralogs
for CCL18 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CCL18 gene
CCL152  CCL162  CCL22  CCL142  CCL242  CCL4L12  CCL112  CCL4L22  
CCL72  CCL3L12  CCL52  CCL232  CCL3L32  CCL42  CCL82  CCL132  
CCL262  CCL32  
18/28 SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):
CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4
CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15
CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

CCL18 for paralogs           About GeneDecksing



Genomic Variants
for CCL18 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

120/166 NCBI SNPs in CCL18 are shown (see all 166)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 17 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1504894801,2
--34389654(+) ATTATC/GATATC 1 -- us2k10--------
rs1809662931,2
--34389736(+) CTCAAC/GCAGGT 1 -- us2k10--------
rs1837240391,2
--34389810(+) TGTACC/TTATTG 1 -- us2k10--------
rs1383437251,2
--34389826(+) GCAAAC/TGCATT 1 -- us2k10--------
rs11029341,2
C,F,H,--34389914(+) CCTGTA/GGACTA 1 -- us2k1 tfbs322Minor allele frequency- G:0.32NS EA NA CSA WA 2354
rs579392061,2
C,F,--34389969(+) TTTCAT/CGTATC 1 -- us2k13Minor allele frequency- C:0.06WA 122
rs1154051801,2
F,--34390003(+) TTACAT/CTGGTG 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs1413417171,2
--34390035(+) ATAGAA/CAAGAA 1 -- us2k10--------
rs1451313541,2
--34390117(+) CAGCAC/TTTTGG 1 -- us2k10--------
rs1385904661,2
--34390257(+) CACAGG/TAGGCT 1 -- us2k10--------
rs45349011,2
C,F,--34390278(+) AATCGC/TTTAAA 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
rs1444238711,2
--34390281(+) CGCTTA/GAACCC 1 -- us2k10--------
rs1123701701,2
--34390340(+) CTAGAT/CGACAA 1 -- us2k14Minor allele frequency- C:0.10CSA WA NA EA 360
rs25221271,2
C,--34390392(+) AAAAAT/GACAAA 1 -- us2k14Minor allele frequency- G:0.09CSA WA NA EA 360
rs588433791,2
C,F,--34390537(+) TTAACA/TTAATG 1 -- us2k15Minor allele frequency- T:0.16WA CSA NA 244
rs620796961,2
F,--34390628(+) TAAACC/TGAGTA 1 -- us2k15Minor allele frequency- T:0.10NA CSA WA EA 362
rs1896185851,2
--34390648(+) GCCCTC/TTCTAA 1 -- us2k10--------
rs1479871311,2
--34390656(+) TAATGC/TGGTGG 1 -- us2k10--------
rs1820825711,2
--34390676(+) AATTAC/GTTGAA 1 -- us2k10--------
rs1869689201,2
--34390798(+) GAAACA/GTCATC 1 -- us2k10--------
rs578443921,2
C,F,--34390902(+) ACCCTG/TCAGAT 1 -- us2k13Minor allele frequency- T:0.07WA 122
rs1416445421,2
--34390966(+) TTTTTA/GTACAC 1 -- us2k10--------
rs1149261091,2
F,--34391013(+) TATACA/GATGGT 1 -- us2k11Minor allele frequency- G:0.05WA 118
rs1125792001,2
C,--34391034(+) AGTTGC/TCAAGG 1 -- us2k12Minor allele frequency- T:0.06CSA WA 120
rs1505842121,2
--34391043(+) GGTCCA/TTTGGG 1 -- us2k10--------
rs27029521,2
H--34391073(+) aaatcT/Ctgaat 1 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 418
rs26875001,2
H--34391205(-) gagaaA/Gtcttc 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NS EA 420
rs728317861,2
C,F,--34391237(+) CTGTAT/CATAAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
rs19672931,2
C,F,A,H,--34391274(+) AGGAAA/TAACAA 1 -- us2k1 trp322Minor allele frequency- T:0.07NS EA NA WA 2588
rs1914120261,2
--34391306(+) TTCTGA/CTCTAT 1 -- us2k10--------
rs1814264231,2
--34391448(+) TCTCCA/GTAAGC 1 -- us2k10--------
rs1855924031,2
--34391479(+) CACTCA/GTTTGT 1 -- us2k10--------
rs20150861,2
C,F,O,A,H,--34391617(-) GCTGTT/CGTCTC 1 -- us2k131Minor allele frequency- C:0.19NS EA NA WA CSA 4408
rs732907721,2
C,F,--34391721(+) CAGCTG/ACCCTC 2 /T /A mis15Minor allele frequency- A:0.01WA NA EU 5997
rs20150701,2
C,F,O,A,H,--34391783(-) ACATGG/AATGAC 1 -- int139Minor allele frequency- A:0.08NA EA NS MN WA EU 6724
rs1998921631,2
--34391786(+) ATCCAC/TGTGCT 1 -- int10--------
rs790204371,2
C,F,--34391990(+) GAGATG/AGTTGA 1 -- int11Minor allele frequency- A:0.05EA 120
rs20150521,2
C,F,A,H,--34392013(-) CTAATA/CACCCA 1 -- int121Minor allele frequency- C:0.10NS EA NA WA CSA 1702
rs779759171,2
C,--34392020(+) TTAGCG/ATGAGG 1 -- int12Minor allele frequency- A:0.06CSA WA 120
rs1150397041,2
F,--34392033(+) GAATCT/CAGGTC 1 -- int11Minor allele frequency- C:0.02WA 118
rs1406484981,2
--34392152(+) GTGATC/TTAATC 1 -- int10--------
rs99096141,2
C,--34392172(+) AAAAAA/TTCCCC 1 -- int10--------
rs1900504621,2
--34392206(+) AGACTA/GTTCAG 1 -- int10--------
rs1823423711,2
--34392215(+) AGGGAC/GCTTGA 1 -- int10--------
rs1474051711,2
--34392298(+) GCCAGA/GTTATT 1 -- int10--------
rs1157231541,2
F,--34392485(+) ATTTTC/TGGTTG 1 -- int11Minor allele frequency- T:0.03WA 118
rs1866489631,2
--34392510(+) AGTGGG/TGAGCG 1 -- int10--------
rs7120411,2
C,F,A,H,--34392533(+) AAATCC/TTATGA 1 -- int113Minor allele frequency- T:0.10NA WA CSA EA 375
rs28401621,2
C,F,--34392547(-) GTAATT/CAAAAT 1 -- int15Minor allele frequency- C:0.09NA WA EA 362
rs753006001,2
--34392587(+) ATCACA/GTATTT 1 -- int10--------
rs1447398751,2
--34392594(+) ATTTGC/TTCTTC 1 -- int10--------
rs1456963971,2
--34392615(+) AAATTA/CTTCTG 1 -- int10--------
rs1489234531,2
--34392655(+) TCTTCC/TGCCTA 1 -- int10--------
rs1923092371,2
--34392739(+) ATGTCC/TTCATT 1 -- int10--------
rs1428301281,2
--34392810(+) TGTGCG/TTACGT 1 -- int10--------
rs1511142571,2
--34392814(+) CTTACA/GTGCTC 1 -- int10--------
rs7120421,2
C,F,O,A,H,--34392880(+) GACTGA/GTGCTG 1 -- int134Minor allele frequency- G:0.23EA NA NS CSA WA 4205
rs1414775581,2
--34392986(+) TAACCA/GTGAGG 1 -- int10--------
rs604133141,2
C,F,--34393019(+) AAAAAC/ACAAGT 1 -- int13Minor allele frequency- A:0.07WA 122
rs620796971,2
--34393028(+) GTAAAT/CTTCTT 1 -- int14Minor allele frequency- C:0.09NA WA EA 360
rs1836745471,2
--34393177(+) TTACTC/GTCACT 1 -- int10--------
rs27358351,2
C,F,H,--34393296(+) CCATCA/GTCTCT 1 -- int118Minor allele frequency- G:0.31NS EA NA 2224
rs1887278241,2
--34393305(+) CTAAAC/TCGCTG 1 -- int10--------
rs1928500671,2
--34393455(+) TCCTGA/CCTTTC 1 -- int10--------
rs1829548911,2
--34393828(+) CAACTC/GTAAAC 1 -- int10--------
rs1450864451,2
--34393879(+) GTTAAA/GTGCAT 1 -- int10--------
rs1389715981,2
--34393932(+) CCCCAA/GGGGTT 1 -- int10--------
rs72090921,2
C,--34393970(+) TCACTT/CGTTGG 1 -- int13Minor allele frequency- C:0.17NA WA 6
rs1503177381,2
--34394046(+) TACAAA/GGAGAG 1 -- int10--------
rs1142340161,2
F,--34394212(+) GTGTTA/TATCGG 1 -- int11Minor allele frequency- T:0.03WA 118
rs1872998881,2
--34394233(+) AGAAAG/TGCTTA 1 -- int10--------
rs1917485961,2
--34394337(+) ATGGTC/GATTTC 1 -- int10--------
rs1148794811,2
F,--34394489(+) TATGGG/TAATGA 1 -- int11Minor allele frequency- T:0.03WA 118
rs1172137031,2
--34394528(+) GCTGTT/ATGATT 1 -- int11Minor allele frequency- A:0.01NA 120
rs1839617061,2
--34394565(+) TATGCC/TATCAT 1 -- int10--------
rs1889748141,2
--34394612(+) GACATA/GTGGGG 1 -- int10--------
rs732907831,2
C,F,--34394754(+) ATAACA/CATGAA 1 -- int13Minor allele frequency- C:0.07WA 122
rs1379988781,2
--34394816(+) CCGAGA/GCAAGC 1 -- int10--------
rs1932600241,2
--34394851(+) AGACCA/TGCCTG 1 -- int10--------
rs20142991,2
H--34394852(+) gaccaG/Ccctgg 1 -- int14Minor allele frequency- C:0.00NS EA 418
rs713778771,2
C,--34394857(+) GCCTGA/GCCAAC 1 -- int12Minor allele frequency- G:0.25NA 4
rs1854148121,2
--34394937(+) AGCTAC/TTCAGG 1 -- int10--------
rs1143435811,2
--34395005(+) TCACAC/TCACTG 1 -- int11Minor allele frequency- T:0.01WA 118
rs99445131,2
C,F,H,--34395061(+) gaaaaA/GTTGAA 1 -- int1 trp37Minor allele frequency- G:0.13NS EA WA CSA 540
rs118673831,2
H--34395185(+) CAcagG/Tcatat 1 -- int10--------
rs713778781,2
C,F,--34395192(+) ATATGC/TTGCAT 1 -- int13Minor allele frequency- T:0.06NA WA 122
rs8544701,2
C,F,A,H,--34395239(+) TACAGC/TGGTGG 1 -- int17Minor allele frequency- T:0.30NA EA 256
rs1430514201,2
--34395343(+) CTACAA/GTATTC 1 -- int10--------
rs747464151,2
--34395390(+) AGCTAC/AAGGCT 1 -- int13Minor allele frequency- A:0.02CSA WA NA 240
rs1905575111,2
--34395485(+) AATGAA/CAAGTT 1 -- int10--------
rs2016445901,2
--34395683(+) AACTG-/TTTTTT 1 -- int10--------
rs355807351,2
C,F,--34395690(+) TTTTTA/TAAAAA 1 -- int13Minor allele frequency- T:0.10NA WA 122
rs1816560141,2
--34395739(+) CTTCAA/GTGAAA 1 -- int10--------
rs1388800781,2
--34395846(+) CCCAGC/TTTTGA 1 -- int10--------
rs1170424071,2
--34395895(+) TGTTTT/CCAAAA 1 -- int11Minor allele frequency- C:0.01EA 120
rs1429048321,2
--34395938(+) TTCACA/GTAACA 1 -- int10--------
rs1442777621,2
C--34396380(+) ACTTT-/AAAAAA 1 -- int10--------
rs1858413111,2
--34396393(+) AAAAAA/TTTATA 1 -- int10--------
rs1161286291,2
F,--34396590(+) GAAAGG/CCTTTA 1 -- int11Minor allele frequency- C:0.03WA 118
rs7120431,2
C,F,H,--34396667(+) CTCCTC/TTCACT 1 -- int136Minor allele frequency- T:0.22EA NA NS CSA 3471
rs1473962881,2
--34396696(+) CCAAGA/GGATCA 1 -- int10--------
rs7120441,2
C,F,O,H,--34396784(+) CACCAA/GTATCA 1 -- int124Minor allele frequency- G:0.20NS EA NA WA 2768
rs728317891,2
C,--34396802(+) AAAATT/ATTCCC 1 -- int12Minor allele frequency- A:0.05NA 122
rs1396901631,2
--34396853(+) AATATC/GTGGGT 1 -- int10--------
rs1417506301,2
--34397076(+) GAGTTC/TAGCTC 1 -- int10--------
rs1508470531,2
--34397117(+) CCCAGA/CATCCT 1 -- int10--------
rs1393282481,2
--34397133(+) CCCCTG/TCAGTT 1 -- int10--------
rs1499828371,2
--34397215(+) TTGCTA/CTTGTG 1 -- int10--------
rs732907851,2
C,F,--34397227(+) CCCTAC/ATGTCT 1 -- int13Minor allele frequency- A:0.07WA 122
rs8544711,2
C,F,O,--34397258(+) TGCCCA/GAGTCT 1 -- int15Minor allele frequency- G:0.23NA WA EA 362
rs1465483301,2
--34397297(+) CAGAGA/GGATTT 1 -- int10--------
rs1401634141,2
--34397422(+) GCCCAC/TGGGGA 1 -- int10--------
rs1887391621,2
--34397455(+) GGTCCA/TATTGG 1 -- int10--------
rs1439227331,2
--34397456(+) GTCCAA/GTTGGT 1 -- int10--------
rs1810395011,2
--34397551(+) AAACTA/GAATTT 1 -- int10--------
rs1851188561,2
--34397554(+) CTAAAC/TTTCCA 1 -- int10--------
rs8544721,2
C,F,A,H,--34397608(-) TTGGTA/GTTTCT 1 -- int114Minor allele frequency- G:0.26EA NA 705
rs2020273331,2
--34397771(+) GTGAAC/TAATGA 1 -- int10--------
rs2010081801,2
C,--34397865(+) CAAAAG/ATTCAT 2 /K syn11Minor allele frequency- A:0.00EU 1323
rs1152447061,2
C,--34397947(+) CCCCTC/TGGGAG 1 -- int11Minor allele frequency- T:0.01WA 118

HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CCL18
     3 CNVs: 34507 8842 4031

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL18
DNA2.0 Custom Variant and Variant Library Synthesis for CCL18

Disorders / Diseases
for CCL18 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
CCL18 for disorders           About GeneDecksing

OMIM gene information: 603757    OMIM disorders: --

20/55 diseases for CCL18 (see all 55):    About MalaCards
niemann-pick disease    human t-cell leukemia virus type 1    idiopathic interstitial pneumonia    pulmonary fibrosis
gaucher's disease    pick's disease    idiopathic pulmonary fibrosis    septic arthritis
interstitial lung disease    atopic dermatitis    acute lymphoblastic leukemia    rheumatoid arthritis
dermatitis    lymphoblastic leukemia    allergic asthma    epithelial ovarian cancer
skin disease    malignant glioma    sarcoidosis    bronchiolitis

2 diseases from the University of Copenhagen DISEASES database for CCL18:
Gaucher's disease     Atopic dermatitis

10/15 Novoseek disease relationships for CCL18 gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gaucher disease 66 5 16125420 (2), 15702402 (2), 15895712 (1)
dermatitis atopic 58.5 5 15494534 (2), 15967069 (1), 17369706 (1), 17979978 (1)
pulmonary fibrosis 53.6 5 12805086 (2), 17569779 (1), 16142750 (1)
dermatitis 38.7 1 15494534 (1)
skin diseases 35.6 2 15784687 (1), 15494534 (1)
necrosis 30.9 10 17545016 (1), 16671879 (1), 17569779 (1), 10569653 (1) (see all 8)
inflammation 24.3 6 17569779 (1), 19017877 (1), 19958819 (1)
sarcoidosis 21.2 5 19808030 (4), 12161279 (1)
tumors 7.61 10 10961902 (1), 17545016 (1), 16671879 (1), 17569779 (1) (see all 8)
atherosclerotic plaque 7.31 2 10027395 (2)

Human Genome Epidemiology (HuGE) Navigator: CCL18 (12 documents)

Export disorders for CCL18 gene to outside databases

Publications
for CCL18 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CCL18 gene, integrated from 9 sources (see all 141):
(articles sorted by number of sources associating them with CCL18)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)1, 2, 3, 9 Hieshima K.... Nomiyama H. (1997)
  2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)1, 2, 3, 9 Tasaki Y.... Nomiyama H. (1999)
  3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)1, 2, 9 Schutyser E.... Van Damme J. (2001)
  4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)1, 2, 9 Guan P.... McColl S.R. (1999)
  5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)1, 2, 9 Adema G.J....Figdor C.G. (1997)
  6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)1, 2, 9 Kodelja V.... Goerdt S. (1998)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. (PubMed id 11978786)1, 2 Schutyser E.... Van Damme J. (2002)
  9. The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)1, 2 Wells T.N.C. and Peitsch M.C. (1997)
  10. Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. (PubMed id 12716654)1, 9 Schraufstatter I....DiScipio R.G. (2004)

External Searches for CCL18 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing CCL18 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6362 HGNC: 10616 AceView: CCL18 Ensembl:ENSG00000006074 euGenes: HUgn6362
ECgene: CCL18 Kegg: 6362 H-InvDB: CCL18

Other Databases showing CCL18 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing CCL18 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CCL18 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL18

Intellectual Property
for CCL18 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CCL18 gene:
Search GeneIP for patents involving CCL18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for CCL18 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section

 
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