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Aliases for CCL18 Gene

Aliases for CCL18 Gene

  • Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated) 2 3
  • SCYA18 3 4 6
  • AMAC1 3 4 6
  • DCCK1 3 4 6
  • PARC 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And Activation-Regulated 2 3
  • Alternative Macrophage Activation-Associated CC Chemokine 1 3 4
  • Pulmonary And Activation-Regulated Chemokine 3 4
  • Macrophage Inflammatory Protein 4 3 4
  • Small-Inducible Cytokine A18 3 4
  • Dendritic Cell Chemokine 1 3 4
  • CC Chemokine PARC 3 4
  • AMAC-1 3 4
  • DC-CK1 3 4
  • MIP-4 3 4
  • Small Inducible Cytokine A18 3
  • Chemokine (C-C), Dendritic 3
  • C-C Motif Chemokine 18 3
  • CC Chemokine Ligand 18 3
  • CKb7 3
  • MIP4 4

External Ids for CCL18 Gene

Previous Symbols for CCL18 Gene

  • SCYA18

Summaries for CCL18 Gene

Entrez Gene Summary for CCL18 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL18 Gene

CCL18 (Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)) is a Protein Coding gene. Diseases associated with CCL18 include allergic asthma and pulmonary fibrosis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL18 Gene

  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL18 Gene

Genomics for CCL18 Gene

Genomic Location for CCL18 Gene

Start:
36,064,280 bp from pter
End:
36,072,032 bp from pter
Size:
7,753 bases
Orientation:
Plus strand

Genomic View for CCL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL18 Gene

Regulatory Elements for CCL18 Gene

Proteins for CCL18 Gene

  • Protein details for CCL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55774-CCL18_HUMAN
    Recommended name:
    C-C motif chemokine 18
    Protein Accession:
    P55774
    Secondary Accessions:
    • B5BUM2
    • Q53X71

    Protein attributes for CCL18 Gene

    Size:
    89 amino acids
    Molecular mass:
    9849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL18 Gene

neXtProt entry for CCL18 Gene

Proteomics data for CCL18 Gene at MOPED

Post-translational modifications for CCL18 Gene

Other Protein References for CCL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL18 Gene

Domains for CCL18 Gene

Gene Families for CCL18 Gene

HGNC:
  • CCL :Chemokine ligands

Protein Domains for CCL18 Gene

UniProtKB/Swiss-Prot:

CCL18_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • P55774
genes like me logo Genes that share domains with CCL18: view

Function for CCL18 Gene

Molecular function for CCL18 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
UniProtKB/Swiss-Prot Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.

Gene Ontology (GO) - Molecular Function for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21481794
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL18: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL18 Gene

Localization for CCL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL18 Gene COMPARTMENTS Subcellular localization image for CCL18 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL18: view

Pathways for CCL18 Gene

genes like me logo Genes that share pathways with CCL18: view

Pathways by source for CCL18 Gene

Gene Ontology (GO) - Biological Process for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 9192897
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007154 cell communication TAS 9192897
GO:0007165 signal transduction TAS 9233607
genes like me logo Genes that share ontologies with CCL18: view

Compounds for CCL18 Gene

(10) Novoseek inferred chemical compound relationships for CCL18 Gene

Compound -log(P) Hits PubMed IDs
tarc 79.7 8
larc 75.2 5
ccl3 71 4
rantes 54.8 9
ofloxacin 25.8 2
genes like me logo Genes that share compounds with CCL18: view

Transcripts for CCL18 Gene

mRNA/cDNA for CCL18 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL18 Gene

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL18 Gene

No ASD Table

Relevant External Links for CCL18 Gene

GeneLoc Exon Structure for
CCL18
ECgene alternative splicing isoforms for
CCL18

Expression for CCL18 Gene

mRNA expression in normal human tissues for CCL18 Gene

mRNA differential expression in normal tissues according to GTEx for CCL18 Gene

This gene is overexpressed in Lung (25.8) and Artery - Aorta (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCL18 Gene

SOURCE GeneReport for Unigene cluster for CCL18 Gene Hs.143961

mRNA Expression by UniProt/SwissProt for CCL18 Gene

P55774-CCL18_HUMAN
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.
genes like me logo Genes that share expressions with CCL18: view

Orthologs for CCL18 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL18 36
  • 99.25 (n)
  • 97.75 (a)
Species with no ortholog for CCL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL18 Gene

ENSEMBL:
Gene Tree for CCL18 (if available)
TreeFam:
Gene Tree for CCL18 (if available)

Paralogs for CCL18 Gene

Selected SIMAP similar genes for CCL18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL18: view

No data available for Paralogs for CCL18 Gene

Variants for CCL18 Gene

Sequence variations from dbSNP and Humsavar for CCL18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs712041 -- 36,065,173(+) AAATC(C/T)TATGA intron-variant
rs712042 -- 36,065,520(+) GACTG(A/G)TGCTG intron-variant
rs712043 -- 36,069,307(+) CTCCT(C/T)TCACT intron-variant
rs712044 -- 36,069,424(+) CACCA(A/G)TATCA intron-variant
rs766555 -- 36,071,292(-) GAAAG(A/G)ATGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCL18 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv120e55 CNV Gain 17911159
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850

Relevant External Links for CCL18 Gene

HapMap Linkage Disequilibrium report
CCL18

Disorders for CCL18 Gene

(2) University of Copenhagen DISEASES for CCL18 Gene

(15) Novoseek inferred disease relationships for CCL18 Gene

Disease -log(P) Hits PubMed IDs
gaucher disease 66 5
dermatitis atopic 58.5 5
pulmonary fibrosis 53.6 4
dermatitis 38.7 1
skin diseases 35.6 2

Relevant External Links for CCL18

Genetic Association Database (GAD)
CCL18
Human Genome Epidemiology (HuGE) Navigator
CCL18
genes like me logo Genes that share disorders with CCL18: view

No data available for UniProtKB/Swiss-Prot for CCL18 Gene

Publications for CCL18 Gene

  1. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PMID: 10049593) Tasaki Y. … Nomiyama H. (Genomics 1999) 2 3 4 23
  2. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PMID: 9233607) Hieshima K. … Nomiyama H. (J. Immunol. 1997) 2 3 4 23
  3. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PMID: 9570561) Kodelja V. … Goerdt S. (J. Immunol. 1998) 3 4 23
  4. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PMID: 11745396) Schutyser E. … Van Damme J. (Eur. J. Immunol. 2001) 3 4 23
  5. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PMID: 10087196) Guan P. … McColl S.R. (Genomics 1999) 3 4 23

Products for CCL18 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL18
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL18
    • Block miRNA regulation of CCL18 using miScript Target Protectors

    Sources for CCL18 Gene

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