Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCL18 Gene

protein-coding   GIFtS: 54
GCID: GC17P034391

Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 18,...)
(Previous symbol: SCYA18)
  See CCL18-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chemokine (C-C Motif) Ligand 18 (Pulmonary And
Activation-Regulated)1 2
     AMAC-12 3
SCYA181 2 3 5     DC-CK12 3
AMAC12 3 5     MIP-42 3
DCCK12 3 5     CC Chemokine PARC2 3
PARC2 3 5     CKb72
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And
Activation-Regulated1 2
     C-C Motif Chemokine 182
Alternative Macrophage Activation-Associated CC Chemokine 12 3     CC Chemokine Ligand 182
Dendritic Cell Chemokine 12 3     Chemokine (C-C), Dendritic2
Macrophage Inflammatory Protein 42 3     Small Inducible Cytokine A182
Pulmonary And Activation-Regulated Chemokine2 3     MIP43
Small-Inducible Cytokine A182 3     

External Ids:    HGNC: 106161   Entrez Gene: 63622   Ensembl: ENSG000000060747   OMIM: 6037575   UniProtKB: P557743   

Export aliases for CCL18 gene to outside databases

Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCL18 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes.
This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It
may play a role in both humoral and cell-mediated immunity responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL18 Gene:
CCL18 (chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)) is a protein-coding gene. Diseases associated with CCL18 include allergic asthma, and pulmonary fibrosis. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  NT_187661.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL18 gene promoter:
         POU2F2 (Oct-2.1)   TBP   AML1a   p53   POU2F2   YY1   POU2F2C   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL18 promoter sequence
   Search Chromatin IP Primers for CCL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL18 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

Start:
34,391,640 bp from pter      End:
34,399,392 bp from pter
Size:
7,753 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774 (See protein sequence)
Recommended Name: C-C motif chemokine 18 precursor  
Size: 89 amino acids; 9849 Da
Mass spectrometry: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396;
Secondary accessions: B5BUM2 Q53X71

Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

Explore proteomics data for CCL18 at MOPED

Post-translational modifications: 

  • The Cys-30/Cys-54 disulfide bond is required for activity1
  • Modification sites at neXtProt

  • See CCL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002979.1  
    ENSEMBL proteins: 
     ENSP00000004921  

    CCL18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL18 (CCL18/PARC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCL18
    OriGene Protein Over-expression Lysate for CCL18
    OriGene MassSpec for CCL18
    OriGene Custom Protein Services for CCL18
    GenScript Purified and Recombinant Proteins for CCL18
    Novus Biologicals CCL18 Proteins
    Novus Biologicals CCL18 Lysate
    Sino Biological Recombinant Protein for CCL18
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL18
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL18 

     
    antibodies-online proteins for CCL18 (2 products) 

     
    antibodies-online peptides for CCL18

    CCL18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL18 (CCL18/PARC)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL18
    Novus Biologicals CCL18 Antibodies
    Search for Antibodies for CCL18 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL18
    antibodies-online antibodies for CCL18 (39 products) 

    CCL18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL18
    R&D Systems ELISAs for CCL18 (CCL18/PARC)         (see all)
    GenScript Custom Assay Services for CCL18
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL18 
    antibodies-online kits for CCL18 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P55774

    ProtoNet protein and cluster: P55774

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL18_HUMAN, P55774
    Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
    B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
    activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
    may play a role in both humoral and cell-mediated immunity responses
    Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10.
    Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in
    combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937
    cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CCL18           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL18

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CCL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCL18
    SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL18
    Predesigned siRNA for gene silencing in human, mouse, rat CCL18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL18

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL18 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
    Sino Biological Human cDNA Clone for CCL18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL18
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CCL18_HUMAN, P55774: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CCL18 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL18
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL18 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    2 Kegg Pathways  (Kegg details for CCL18):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL18: 
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CCL18 (P557741, 2, 3 ENSP000000049214) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1Q9UKR52, 3MINT-63888 I2D: score=6 
    TP53P046372, 3MINT-63883 I2D: score=6 
    UNC119Q134322, 3MINT-63885 I2D: score=6 
    CRMP1Q141942, 3MINT-63886 I2D: score=5 
    TLE1Q047242, 3MINT-63884 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS9192897
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007154cell communication TAS9192897
    GO:0007165signal transduction TAS9233607

    Find genes that share ontologies with CCL18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL18

    10 Novoseek inferred chemical compound relationships for CCL18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 79.7 9 9365118 (2), 11358988 (2), 11159181 (1), 18086588 (1) (see all 6)
    larc 75.2 6 9365118 (2), 10027395 (2), 12239608 (1)
    ccl3 71 5 16773571 (2), 17369706 (1), 15588486 (1)
    rantes 54.8 9 10744077 (4), 17909104 (2), 10559506 (1), 11576227 (1) (see all 5)
    ofloxacin 25.8 2 12878509 (1), 19745030 (1)
    ccl4 18.3 3 16773571 (2), 17369706 (1)
    vegf 3.95 2 16671879 (1), 17082335 (1)
    calcium 0 2 10087196 (1), 16601239 (1)
    alanine 0 1 10744077 (1)
    dexamethasone 0 3 12161279 (2), 12673080 (1)



    Find genes that share compounds with CCL18           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCL18 gene: 
    NM_002988.2  

    Unigene Cluster for CCL18:

    Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
    Hs.143961  [show with all ESTs]
    Unigene Representative Sequence: Y13710
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000004921(uc002hku.3) ENST00000586857
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCL18
    SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCL18
    Predesigned siRNA for gene silencing in human, mouse, rat CCL18
    Clone
    Products:
         
    OriGene clones in human, mouse for CCL18 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL18
      QuantiTect SYBR Green Assays in human, mouse, rat CCL18
      QuantiFast Probe-based Assays in human, mouse, rat CCL18

    Additional mRNA sequence: 

    AB000221.1 AB451458.1 BC069700.1 BC096124.3 BC096125.3 BC096126.1 BC096127.1 CR407660.1 
    Y13710.1 

    2 DOTS entries:

    DT.314426  DT.100748759 

    73 AceView cDNA sequences (see top 24):

    AA425047 CA440845 AA296912 BM991019 CA435401 CR407660 BX116770 AA729801 
    AW264712 AB000221 NM_002988 BQ025756 CA428280 BU617136 BQ447593 AI969253 
    AI828910 N44551 AU100459 BC069700 CD366385 AI299310 BQ772229 BU617575 
    CD368040 BQ575232 AW269476 BM987388 CA308169 AA031820 BU616134 AI971607 
    BU623510 BF813962 CA428234 CA412963 CD368696 Y13710 CD368336 AI887150 
    AA421837 CD368969 D79909 AW662706 AI274247 C16714 AA973804 D61983 
    AW967045 BQ183732 AI814602 AA495985 AA296910 AA303043 AA296914 AI800568 
    D79975 BE550826 T89961 AA988143 AA298074 AA031821 CD366066 N33793 
    AW206566 R83915 T89325 AI262817 D62820 CD616057 AA877344 BF770098 
    AV713928 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAATCAG
    CCL18 Expression
    About this image

    CCL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143961

    UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
    Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present
    in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood
    monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a
    prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and
    in ovarian carcinoma ascitic fluid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL18: 
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL18
    QuantiTect SYBR Green Assays in human, mouse, rat CCL18
    QuantiFast Probe-based Assays in human, mouse, rat CCL18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL18 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CCLI86
    Gallus gallus chemokine ah221 (LOC417536), mRNA.
    38(a)
    many ↔ many
    19(4812218-4813843)
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    31(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378
            Species with no ortholog for CCL18

    ENSEMBL Gene Tree for CCL18 (if available)
    TreeFam Gene Tree for CCL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CCL18 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
    CCL52  CCL232  CCL3L32  CCL42  CCL15-CCL142  
    Selected SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):
    CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4
    CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15
    CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

    Find genes that share paralogs with CCL18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for CCL18    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355110821,2
    C--34395689(+) TTTTA-/AAAAAA 1 -- int10--------
    rs3770536801,2
    ----34395745(+) TTTTT-/TCAGGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CCL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833427CNV Loss17160897
    dgv120e55CNV Gain17911159
    nsv833424CNV Gain17160897
    nsv428340CNV Gain18775914
    dgv945e1CNV Complex17122850
    dgv946e1CNV Complex17122850
    dgv947e1CNV Complex17122850
    dgv948e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL18
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603757    OMIM disorders: --

    4 diseases for CCL18:    
    About MalaCards
    allergic asthma    pulmonary fibrosis    atopic dermatitis    idiopathic pulmonary fibrosis

    2 diseases from the University of Copenhagen DISEASES database for CCL18:
    Gaucher's disease     Atopic dermatitis

    Find genes that share disorders with CCL18           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL18 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaucher disease 66 5 16125420 (2), 15702402 (2), 15895712 (1)
    dermatitis atopic 58.5 5 15494534 (2), 15967069 (1), 17369706 (1), 17979978 (1)
    pulmonary fibrosis 53.6 5 12805086 (2), 17569779 (1), 16142750 (1)
    dermatitis 38.7 1 15494534 (1)
    skin diseases 35.6 2 15784687 (1), 15494534 (1)
    necrosis 30.9 10 17545016 (1), 16671879 (1), 17569779 (1), 10569653 (1) (see all 8)
    inflammation 24.3 6 17569779 (1), 19017877 (1), 19958819 (1)
    sarcoidosis 21.2 5 19808030 (4), 12161279 (1)
    tumors 7.61 10 10961902 (1), 17545016 (1), 16671879 (1), 17569779 (1) (see all 8)
    atherosclerotic plaque 7.31 2 10027395 (2)

    Genetic Association Database (GAD): CCL18
    Human Genome Epidemiology (HuGE) Navigator: CCL18 (12 documents)

    Export disorders for CCL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCL18 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with CCL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)1, 2, 3, 9 Hieshima K.... Nomiyama H. (J. Immunol. 1997)
    2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)1, 2, 3, 9 Tasaki Y.... Nomiyama H. (Genomics 1999)
    3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)1, 2, 9 Schutyser E.... Van Damme J. (Eur. J. Immunol. 2001)
    4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)1, 2, 9 Guan P.... McColl S.R. (Genomics 1999)
    5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)1, 2, 9 Adema G.J....Figdor C.G. (Nature 1997)
    6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)1, 2, 9 Kodelja V.... Goerdt S. (J. Immunol. 1998)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6362 HGNC: 10616 AceView: CCL18 Ensembl:ENSG00000006074 euGenes: HUgn6362
    ECgene: CCL18 Kegg: 6362 H-InvDB: CCL18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCL18 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL18

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCL18 gene:
    Search GeneIP for patents involving CCL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CCL18 (CCL18/PARC)   Browse Cell Culture Products  
     ELISAs for CCL18 (CCL18/PARC)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for CCL18 (CCL18/PARC)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CCL18 (CCL18/PARC)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CCL18 (CCL18/PARC)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCL18  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CCL18  
     OriGene MassSpec for CCL18   OriGene clones in human, mouse for CCL18  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCL18   OriGene Purified Protein for CCL18  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCL18   OriGene Custom Protein Services for CCL18  

     
     
     Block miRNA regulation of human, mouse, rat CCL18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCL18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL18 Predesigned siRNA for gene silencing in human, mouse, rat CCL18
     QuantiFast Probe-based Assays in human, mouse, rat CCL18 QuantiTect SYBR Green Assays in human, mouse, rat CCL18
     PCR Arrays including human, mouse / rat CCL18 Search Chromatin IP Primers for CCL18
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL18  Search GeneGlobe Interaction Network for CCL18
     Regulatory tfbs in CCL18 promoter
     GenScript Purified and Recombinant Proteins for CCL18 GenScript cDNA clones with any tag delivered in your preferred vector for CCL18
     GenScript Custom Assay Services for CCL18 GenScript Custom overexpressing Cell Line Services for CCL18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CCL18
     Proteins for CCL18
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCL18
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCL18 antibodies
     CCL18 proteins
     CCL18 lysates
     Search for Antibodies for CCL18 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CCL18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CCL18
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCL18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18
     SwitchGear 3'UTR luciferase reporter plasmids for CCL18
     SwitchGear Promoter luciferase reporter plasmids for CCL18
     ThermoFisher Antibodies for CCL18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
     Browse compounds at ApexBio
     Search Addgene for plasmids for CCL18
      Search eBioscience for proteins for CCL18
      Search eBioscience for elisas for CCL18
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CCL18
     antibodies-online antibodies for CCL18 (39 products)
     antibodies-online kits for CCL18 (10 products)
     antibodies-online peptides for CCL18
     antibodies-online proteins for CCL18 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCL18 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4