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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL18 Gene

protein-coding   GIFtS: 56
GCID: GC17P034391

Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 18,...)
(Previous symbol: SCYA18)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 18 (Pulmonary And
Activation-Regulated)1 2
     AMAC-12 3
SCYA181 2 3 5     DC-CK12 3
AMAC12 3 5     MIP-42 3
DCCK12 3 5     CC Chemokine PARC2 3
PARC2 3 5     CKb72
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And
Activation-Regulated1 2
     C-C Motif Chemokine 182
Alternative Macrophage Activation-Associated CC Chemokine 12 3     CC Chemokine Ligand 182
Dendritic Cell Chemokine 12 3     Chemokine (C-C), Dendritic2
Macrophage Inflammatory Protein 42 3     Small Inducible Cytokine A182
Pulmonary And Activation-Regulated Chemokine2 3     MIP43
Small-Inducible Cytokine A182 3     

External Ids:    HGNC: 106161   Entrez Gene: 63622   Ensembl: ENSG000000060747   OMIM: 6037575   UniProtKB: P557743   

Export aliases for CCL18 gene to outside databases

Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL18 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes.
This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It
may play a role in both humoral and cell-mediated immunity responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL18 Gene: 
CCL18 (chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)) is a protein-coding gene. Diseases associated with CCL18 include septic arthritis, and gaucher's disease, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include protein binding and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL18 gene promoter:
         POU2F2 (Oct-2.1)   TBP   AML1a   p53   POU2F2   YY1   POU2F2C   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL18 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

Start:
34,391,640 bp from pter      End:
34,399,392 bp from pter
Size:
7,753 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774 (See protein sequence)
Recommended Name: C-C motif chemokine 18 precursor  
Size: 89 amino acids; 9849 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396;
Secondary accessions: B5BUM2 Q53X71

Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

Explore proteomics data for CCL18 at MOPED 

CCL18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CCL18 Protein Expression

REFSEQ proteins: NP_002979.1  
ENSEMBL proteins: 
 ENSP00000004921  

Human Recombinant Protein Products for CCL18: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL18 (CCL18/PARC)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CCL18
OriGene Protein Over-expression Lysate for CCL18
OriGene MassSpec for CCL18 
OriGene Custom Protein Services for CCL18
GenScript Purified and Recombinant Proteins for CCL18
Novus Biologicals CCL18 Proteins
Novus Biologicals CCL18 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for CCL18
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

CCL18 for ontologies           About GeneDecksing



CCL18 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL18 (CCL18/PARC)
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Novus Biologicals CCL18 Antibodies
Abcam antibodies for CCL18
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ThermoFisher Antibodies for CCL18
LSBio Antibodies in human, mouse, rat for CCL18 

Assay Products for CCL18: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL18
R&D Systems ELISAs for CCL18 (CCL18/PARC)         (see all)
GenScript Custom Assay Services for CCL18
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Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P55774

ProtoNet protein and cluster: P55774

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Similarity: Belongs to the intercrine beta (chemokine CC) family


CCL18 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses
Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10.
Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in
combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937
cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0008009chemokine activity IEA--
     
CCL18 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL18 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL18

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL18 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL18 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL18
Sirion Biotech Customized adenovirus for overexpression of CCL18

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CCL18 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
Sino Biological Human cDNA Clone for CCL18
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
Sirion Biotech Customized lentivirus for stable overexpression of CCL18 
                     Customized lentivirus expression plasmids for stable overexpression of CCL18 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCL18
Search LifeMap BioReagents cell lines for CCL18
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CCL18 About   (see all 7)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
3TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL18 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway



2         Kegg Pathways  (Kegg details for CCL18):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway


CCL18 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCL18

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/31 Interacting proteins for CCL18 (P557741, 2, 3 ENSP000000049214) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
InteractantInteraction Details
GeneCardExternal ID(s)
C14orf1Q9UKR52, 3MINT-63888 I2D: score=6 
TP53P046372, 3MINT-63883 I2D: score=6 
UNC119Q134322, 3MINT-63885 I2D: score=6 
CRMP1Q141942, 3MINT-63886 I2D: score=5 
TLE1Q047242, 3MINT-63884 I2D: score=5 
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007154cell communication TAS9192897
GO:0007165signal transduction TAS9233607

CCL18 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL18 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL18

10 Novoseek inferred chemical compound relationships for CCL18 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 79.7 9 9365118 (2), 11358988 (2), 11159181 (1), 18086588 (1) (see all 6)
larc 75.2 6 9365118 (2), 10027395 (2), 12239608 (1)
ccl3 71 5 16773571 (2), 17369706 (1), 15588486 (1)
rantes 54.8 9 10744077 (4), 17909104 (2), 10559506 (1), 11576227 (1) (see all 5)
ofloxacin 25.8 2 12878509 (1), 19745030 (1)
ccl4 18.3 3 16773571 (2), 17369706 (1)
vegf 3.95 2 16671879 (1), 17082335 (1)
calcium 0 2 10087196 (1), 16601239 (1)
alanine 0 1 10744077 (1)
dexamethasone 0 3 12161279 (2), 12673080 (1)

Search CenterWatch for drugs/clinical trials and news about CCL18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL18 gene: 
NM_002988.2  

Unigene Cluster for CCL18:

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Hs.143961  [show with all ESTs]
Unigene Representative Sequence: Y13710
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000004921(uc002hku.3) ENST00000586857
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18
Clone
Products:
     
OriGene clones in human, mouse for CCL18 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
Sirion Biotech Customized lentivirus for stable overexpression of CCL18 
                     Customized lentivirus expression plasmids for stable overexpression of CCL18 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18

Additional mRNA sequence: 

AB000221.1 AB451458.1 BC069700.1 BC096124.3 BC096125.3 BC096126.1 BC096127.1 CR407660.1 
Y13710.1 

2 DOTS entries:

DT.314426  DT.100748759 

73 AceView cDNA sequences (see top 24):

AW264712 AA425047 BM991019 AA729801 BQ025756 BX116770 CR407660 NM_002988 
AB000221 AA296912 CA440845 CA435401 CA428234 AI828910 BU617575 CA428280 
BM987388 AA421837 CD368696 Y13710 D79909 AI887150 N44551 AA973804 
AA031820 CD368969 BU616134 BQ575232 AW269476 CD368336 CD366385 C16714 
AW662706 AU100459 BF813962 CA412963 AI299310 BQ447593 BQ772229 AI274247 
BC069700 BU623510 CD368040 AI971607 AI969253 CA308169 BU617136 AA031821 
AA303043 AI800568 AA296910 D61983 AA988143 AA296914 AA495985 BE550826 
AW967045 AI814602 T89961 D79975 BQ183732 AA298074 CD366066 N33793 
R83915 AW206566 T89325 D62820 AI262817 AA877344 CD616057 BF770098 
AV713928 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATCAATCAG
CCL18 Expression
About this image


See CCL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL18

SOURCE GeneReport for Unigene cluster: Hs.143961

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present
in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood
monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a
prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and
in ovarian carcinoma ascitic fluid

    SABiosciences Expression via Pathway-Focused PCR Arrays including CCL18: 
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL18 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia CCL186
--
--
57(a)
37(a)
1 ↔ 1
possible ortholog
9(37708572-37711005)
9(37734558-37740115)
chicken
(Gallus gallus)
Aves --
CCLI106
Chemokine; Uncharacterized protein
36(a)
35(a)
many ↔ many
many ↔ many
19(4812218-4813843)
19(4792410-4793550)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-59a8.36
si:dkeyp-59a8.16
(see all 5)
si:dkeyp-59a8.1
(see all 5)
26(a)
25(a)
(see all 5)
many ↔ many
many ↔ many
(see all 5)
20(38310380-38311158)
20(38282475-38302293)


ENSEMBL Gene Tree for CCL18 (if available)
TreeFam Gene Tree for CCL18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CCL18 gene
CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
CCL52  CCL232  CCL3L32  CCL42  CCL15-CCL142  
18/27 SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):
CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4
CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15
CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

CCL18 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in CCL18 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs355110821,2
C--34395689(+) TTTTA-/AAAAAA 1 -- int10--------
rs3770536801,2
----34395745(+) TTTTT-/TCAGGT 1 -- int10--------

HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for CCL18:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833427CNV Loss17160897
dgv120e55CNV Gain17911159
nsv833424CNV Gain17160897
nsv428340CNV Gain18775914
dgv945e1CNV Complex17122850
dgv946e1CNV Complex17122850
dgv947e1CNV Complex17122850
dgv948e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603757    OMIM disorders: --

20/52 diseases for CCL18 (see all 52):    About MalaCards
septic arthritis    gaucher's disease    interstitial lung disease    pulmonary fibrosis
idiopathic interstitial pneumonia    allergic asthma    pterygium    atopic dermatitis
human t-cell leukemia virus type 1    niemann-pick disease    pick's disease    idiopathic pulmonary fibrosis
pneumonia    hiv type 1    skin disease    eczema
measles    dermatitis    behcet's disease    sarcoidosis

2 diseases from the University of Copenhagen DISEASES database for CCL18:
Gaucher's disease     Atopic dermatitis

CCL18 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/15 Novoseek inferred disease relationships for CCL18 gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gaucher disease 66 5 16125420 (2), 15702402 (2), 15895712 (1)
dermatitis atopic 58.5 5 15494534 (2), 15967069 (1), 17369706 (1), 17979978 (1)
pulmonary fibrosis 53.6 5 12805086 (2), 17569779 (1), 16142750 (1)
dermatitis 38.7 1 15494534 (1)
skin diseases 35.6 2 15784687 (1), 15494534 (1)
necrosis 30.9 10 17545016 (1), 16671879 (1), 17569779 (1), 10569653 (1) (see all 8)
inflammation 24.3 6 17569779 (1), 19017877 (1), 19958819 (1)
sarcoidosis 21.2 5 19808030 (4), 12161279 (1)
tumors 7.61 10 10961902 (1), 17545016 (1), 16671879 (1), 17569779 (1) (see all 8)
atherosclerotic plaque 7.31 2 10027395 (2)

Genetic Association Database (GAD): CCL18
Human Genome Epidemiology (HuGE) Navigator: CCL18 (12 documents)

Export disorders for CCL18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCL18 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with CCL18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)1, 2, 3, 9 Hieshima K.... Nomiyama H. (1997)
  2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)1, 2, 3, 9 Tasaki Y.... Nomiyama H. (1999)
  3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)1, 2, 9 Schutyser E.... Van Damme J. (2001)
  4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)1, 2, 9 Guan P.... McColl S.R. (1999)
  5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)1, 2, 9 Adema G.J....Figdor C.G. (1997)
  6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)1, 2, 9 Kodelja V.... Goerdt S. (1998)
  7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  8. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  10. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6362 HGNC: 10616 AceView: CCL18 Ensembl:ENSG00000006074 euGenes: HUgn6362
ECgene: CCL18 Kegg: 6362 H-InvDB: CCL18

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CCL18 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL18

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CCL18 gene:
Search GeneIP for patents involving CCL18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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