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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

CCL18 Gene

protein-coding   GIFtS: 56
GCID: GC17P034391

Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 18,...)
(Previous symbol: SCYA18)
Microbiology & Infectious Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Chemokine (C-C Motif) Ligand 18 (Pulmonary And
Activation-Regulated)1 2
     AMAC-12 3
SCYA181 2 3 5     DC-CK12 3
AMAC12 3 5     MIP-42 3
DCCK12 3 5     CC Chemokine PARC2 3
PARC2 3 5     CKb72
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And
Activation-Regulated1 2
     C-C Motif Chemokine 182
Alternative Macrophage Activation-Associated CC Chemokine 12 3     CC Chemokine Ligand 182
Dendritic Cell Chemokine 12 3     Chemokine (C-C), Dendritic2
Macrophage Inflammatory Protein 42 3     Small Inducible Cytokine A182
Pulmonary And Activation-Regulated Chemokine2 3     MIP43
Small-Inducible Cytokine A182 3     

External Ids:    HGNC: 106161   Entrez Gene: 63622   Ensembl: ENSG000000060747   OMIM: 6037575   UniProtKB: P557743   

Export aliases for CCL18 gene to outside databases

Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL18 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes.
This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It
may play a role in both humoral and cell-mediated immunity responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL18 Gene: 
CCL18 (chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)) is a protein-coding gene. Diseases associated with CCL18 include septic arthritis, and gaucher's disease, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include protein binding and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL18 gene promoter:
         POU2F2 (Oct-2.1)   TBP   AML1a   p53   POU2F2   YY1   POU2F2C   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL18

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL18 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

34,391,640 bp from pter      End:
34,399,392 bp from pter
7,753 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774 (See protein sequence)
Recommended Name: C-C motif chemokine 18 precursor  
Size: 89 amino acids; 9849 Da
Subcellular location: Secreted
Mass spectrometry: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396;
Secondary accessions: B5BUM2 Q53X71

Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

Explore proteomics data for CCL18 at MOPED 

CCL18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CCL18 Protein Expression

REFSEQ proteins: NP_002979.1  
ENSEMBL proteins: 

Human Recombinant Protein Products for CCL18: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL18 (CCL18/PARC)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CCL18
OriGene Protein Over-expression Lysate for CCL18
OriGene MassSpec for CCL18 
OriGene Custom Protein Services for CCL18
GenScript Purified and Recombinant Proteins for CCL18
Novus Biologicals CCL18 Proteins
Novus Biologicals CCL18 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for CCL18
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

CCL18 for ontologies           About GeneDecksing

CCL18 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL18 (CCL18/PARC)
Browse OriGene Antibodies
OriGene Custom Antibody Services for CCL18
GenScript Custom Superior Antibodies Services for CCL18
Novus Biologicals CCL18 Antibodies
Abcam antibodies for CCL18
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibodies for CCL18
LSBio Antibodies in human, mouse, rat for CCL18 

Assay Products for CCL18: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL18
R&D Systems ELISAs for CCL18 (CCL18/PARC)         (see all)
GenScript Custom Assay Services for CCL18
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry P55774

ProtoNet protein and cluster: P55774

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Similarity: Belongs to the intercrine beta (chemokine CC) family

CCL18 for domains           About GeneDecksing

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses
Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10.
Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in
combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937
cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0008009chemokine activity IEA--
CCL18 for ontologies           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL18 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL18

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL18 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL18 

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
Inhib. RNA
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18

Gene Editing
DNA2.0 Custom Protein Engineering Service for CCL18
Sirion Biotech Customized adenovirus for overexpression of CCL18

Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CCL18 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
Sino Biological Human cDNA Clone for CCL18
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
Sirion Biotech Customized lentivirus for stable overexpression of CCL18 
                     Customized lentivirus expression plasmids for stable overexpression of CCL18 

Cell Line
GenScript Custom overexpressing Cell Line Services for CCL18
Search LifeMap BioReagents cell lines for CCL18
In Situ Assay

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CCL18 About   (see all 7)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
3TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL18 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway

2         Kegg Pathways  (Kegg details for CCL18):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

CCL18 for pathways           About GeneDecksing


    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCL18

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/31 Interacting proteins for CCL18 (P557741, 2, 3 ENSP000000049214) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
InteractantInteraction Details
GeneCardExternal ID(s)
C14orf1Q9UKR52, 3MINT-63888 I2D: score=6 
TP53P046372, 3MINT-63883 I2D: score=6 
UNC119Q134322, 3MINT-63885 I2D: score=6 
CRMP1Q141942, 3MINT-63886 I2D: score=5 
TLE1Q047242, 3MINT-63884 I2D: score=5 
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007154cell communication TAS9192897
GO:0007165signal transduction TAS9233607

CCL18 for ontologies           About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL18 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL18

10 Novoseek inferred chemical compound relationships for CCL18 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 79.7 9 9365118 (2), 11358988 (2), 11159181 (1), 18086588 (1) (see all 6)
larc 75.2 6 9365118 (2), 10027395 (2), 12239608 (1)
ccl3 71 5 16773571 (2), 17369706 (1), 15588486 (1)
rantes 54.8 9 10744077 (4), 17909104 (2), 10559506 (1), 11576227 (1) (see all 5)
ofloxacin 25.8 2 12878509 (1), 19745030 (1)
ccl4 18.3 3 16773571 (2), 17369706 (1)
vegf 3.95 2 16671879 (1), 17082335 (1)
calcium 0 2 10087196 (1), 16601239 (1)
alanine 0 1 10744077 (1)
dexamethasone 0 3 12161279 (2), 12673080 (1)

Search CenterWatch for drugs/clinical trials and news about CCL18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL18 gene: 

Unigene Cluster for CCL18:

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Hs.143961  [show with all ESTs]
Unigene Representative Sequence: Y13710
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000004921(uc002hku.3) ENST00000586857
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL18
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL18
SwitchGear 3'UTR luciferase reporter plasmidCCL18 3' UTR sequence
Inhib. RNA
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CCL18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18
OriGene clones in human, mouse for CCL18 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
Sirion Biotech Customized lentivirus for stable overexpression of CCL18 
                     Customized lentivirus expression plasmids for stable overexpression of CCL18 
OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18

Additional mRNA sequence: 

AB000221.1 AB451458.1 BC069700.1 BC096124.3 BC096125.3 BC096126.1 BC096127.1 CR407660.1 

2 DOTS entries:

DT.314426  DT.100748759 

24/73 AceView cDNA sequences (see all 73):

AW264712 AA425047 BM991019 AA729801 BQ025756 BX116770 CR407660 NM_002988 
AB000221 AA296912 CA440845 CA435401 CA428234 AI828910 BU617575 CA428280 
BM987388 AA421837 CD368696 Y13710 D79909 AI887150 N44551 AA973804 

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CCL18 Expression
About this image

See CCL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL18

SOURCE GeneReport for Unigene cluster: Hs.143961

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present
in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood
monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a
prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and
in ovarian carcinoma ascitic fluid

    SABiosciences Expression via Pathway-Focused PCR Arrays including CCL18: 
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL18
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18
In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL18 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
Gene Description Human
(Canis familiaris)
Mammalia CCL186
1 ↔ 1
possible ortholog
(Gallus gallus)
Aves --
Chemokine; Uncharacterized protein
many ↔ many
many ↔ many
(Danio rerio)
Actinopterygii si:dkeyp-59a8.36
(see all 5)
(see all 5)
(see all 5)
many ↔ many
many ↔ many
(see all 5)

ENSEMBL Gene Tree for CCL18 (if available)
TreeFam Gene Tree for CCL18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
About This Section
Paralogs for CCL18 gene
CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
CCL52  CCL232  CCL3L32  CCL42  CCL15-CCL142  
18/27 SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):
CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4
CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15
CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

CCL18 for paralogs           About GeneDecksing

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in CCL18 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
Chr 17 posSequence#AA
C--34395689(+) TTTTA-/AAAAAA 1 -- int10--------
----34395745(+) TTTTT-/TCAGGT 1 -- int10--------

HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for CCL18:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833427CNV Loss17160897
dgv120e55CNV Gain17911159
nsv833424CNV Gain17160897
nsv428340CNV Gain18775914
dgv945e1CNV Complex17122850
dgv946e1CNV Complex17122850
dgv947e1CNV Complex17122850
dgv948e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CCL18
DNA2.0 Custom Variant and Variant Library Synthesis for CCL18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603757    OMIM disorders: --

20/52 diseases for CCL18 (see all 52):    About MalaCards
septic arthritis    gaucher's disease    interstitial lung disease    pulmonary fibrosis
idiopathic interstitial pneumonia    allergic asthma    pterygium    atopic dermatitis
human t-cell leukemia virus type 1    niemann-pick disease    pick's disease    idiopathic pulmonary fibrosis
pneumonia    hiv type 1    skin disease    eczema
measles    dermatitis    behcet's disease    sarcoidosis

2 diseases from the University of Copenhagen DISEASES database for CCL18:
Gaucher's disease     Atopic dermatitis

CCL18 for disorders           About GeneDecksing

Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/15 Novoseek inferred disease relationships for CCL18 gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gaucher disease 66 5 16125420 (2), 15702402 (2), 15895712 (1)
dermatitis atopic 58.5 5 15494534 (2), 15967069 (1), 17369706 (1), 17979978 (1)
pulmonary fibrosis 53.6 5 12805086 (2), 17569779 (1), 16142750 (1)
dermatitis 38.7 1 15494534 (1)
skin diseases 35.6 2 15784687 (1), 15494534 (1)
necrosis 30.9 10 17545016 (1), 16671879 (1), 17569779 (1), 10569653 (1) (see all 8)
inflammation 24.3 6 17569779 (1), 19017877 (1), 19958819 (1)
sarcoidosis 21.2 5 19808030 (4), 12161279 (1)
tumors 7.61 10 10961902 (1), 17545016 (1), 16671879 (1), 17569779 (1) (see all 8)
atherosclerotic plaque 7.31 2 10027395 (2)

Genetic Association Database (GAD): CCL18
Human Genome Epidemiology (HuGE) Navigator: CCL18 (12 documents)

Export disorders for CCL18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CCL18 gene, integrated from 9 sources (see all 148) (see top 10):
(articles sorted by number of sources associating them with CCL18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)1, 2, 3, 9 Hieshima K.... Nomiyama H. (1997)
  2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)1, 2, 3, 9 Tasaki Y.... Nomiyama H. (1999)
  3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)1, 2, 9 Schutyser E.... Van Damme J. (2001)
  4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)1, 2, 9 Guan P.... McColl S.R. (1999)
  5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)1, 2, 9 Adema G.J....Figdor C.G. (1997)
  6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)1, 2, 9 Kodelja V.... Goerdt S. (1998)
  7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  8. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  10. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  11. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  12. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
  13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  14. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. (PubMed id 11978786)1, 2 Schutyser E.... Van Damme J. (2002)
  15. The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)1, 2 Wells T.N.C. and Peitsch M.C. (1997)
  16. Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. (PubMed id 12716654)1, 9 Schraufstatter I....DiScipio R.G. (2004)
  17. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. (PubMed id 15494534)1, 9 Pivarcsi A....Homey B. (2004)
  18. Increased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients. (PubMed id 17979978)1, 9 Park C.O....Lee K.H. (2008)
  19. Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis. (PubMed id 19808030)1, 9 Boot R.G....Aerts J.M. (2010)
  20. Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis. (PubMed id 17875202)1, 9 Auer J....Beuscher H.U. (2007)
  21. CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. (PubMed id 17909104)1, 9 Kraaijeveld A.O....Biessen E.A. (2007)
  22. CCL18: a urinary marker of Gaucher cell burden in Gaucher patients. (PubMed id 16736095)1, 9 Boot R.G....Aerts J.M. (2006)
  23. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease. (PubMed id 15702402)1, 9 Brinkman J....Aerts J.M. (2005)
  24. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. (PubMed id 12805086)1, 9 Atamas S.P....White B. (2003)
  25. Expression of the chemokine PARC mRNA in bronchoalveolar cells of patients with sarcoidosis. (PubMed id 12161279)1, 9 Mrazek F....Petrek M. (2002)
  26. Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum. (PubMed id 19017877)1, 9 Kim H.B....Kita H. (2009)
  27. CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain inju ries and neoplastic disorders. (PubMed id 19958819)1, 9 Chang C.Y....Wu C.H. (2010)
  28. Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia virus type 1-associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis. (PubMed id 17900259)1, 9 Shimizu K....Ohshima K. (2007)
  29. Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. (PubMed id 16773571)1, 9 Modi W.S....Winkler C. (2006)
  30. CCL18 production is decreased in alveolar macrophages from cigarette smokers. (PubMed id 19357939)1, 9 Kollert F....Prasse A. (2009)
  31. Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications. (PubMed id 17181634)1, 9 Plager D.A....Pittelkow M.R. (2007)
  32. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. (PubMed id 16415274)1, 9 Prasse A....Zissel G. (2006)
  33. CC-chemokine ligand 18 induces epithelial to mesenchym al transition in lung cancer A549 cells and elevates the invasive potential. (PubMed id 23349697)1 Ploenes T....Zissel G. (2013)
  34. CCL18 as an independent favorable prognostic biomarker in patients with colorectal cancer. (PubMed id 23433718)1 Yuan R....Lan P. (2013)
  35. Segmental allergen challenge enhances chitinase activi ty and levels of CCL18 in mild atopic asthma. (PubMed id 23331560)1 Gavala M.L....Jarjour N.N. (2013)
  36. Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis. (PubMed id 22404649)1 Miyagaki T....Sato S. (2013)
  37. Gene expression profiles in paired gingival biopsies f rom periodontitis-affected and healthy tissues revealed by massively parallel se quencing. (PubMed id 23029519)1 Davanian H....Yucel-Lindberg T. (2012)
  38. CCL18 in a multiplex urine-based assay for the detecti on of bladder cancer. (PubMed id 22629457)1 Urquidi V....Goodison S. (2012)
  39. Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity. (PubMed id 23102918)1 Bellinghausen I....Saloga J. (2012)
  40. Serum level of CC-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in ad enocarcinomas. (PubMed id 22848587)1 Plones T....Zissel G. (2012)
  41. The chemokine CCL18 causes maturation of cultured mono cytes to macrophages in the M2 spectrum. (PubMed id 22117697)1 Schraufstatter I.U....Discipio R.G. (2012)
  42. Increased expression of CC chemokine ligand 18 in pati ents with chronic rhinosinusitis with nasal polyps. (PubMed id 21943944)1 Peterson S....Kato A. (2012)
  43. Chemokines CCL3/MIP1a, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coron ary syndromes. (PubMed id 23029252)1 de Jager S.C....Biessen E.A. (2012)
  44. CCL18 -- potential biomarker of fibroinflammatory acti vity in chronic periaortitis. (PubMed id 22589264)1 Kollert F....Warnatz K. (2012)
  45. Pulmonary CCL18 recruits human regulatory T cells. (PubMed id 22649201)1 Chenivesse C....Tsicopoulos A. (2012)
  46. Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy contr ols. (PubMed id 22203932)1 Narita D....Anghel A. (2011)
  47. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. (PubMed id 21928244)1 Wang Q....Li L. (2011)
  48. CCL18 from tumor-associated macrophages promotes brea st cancer metastasis via PITPNM3. (PubMed id 21481794)1 Chen J....Song E. (2011)
  49. Serum CC chemokine ligand-18 predicts lung disease wor sening in systemic sclerosis. (PubMed id 21778167)1 Tiev K.P....Dinh-Xuan A.T. (2011)
  50. Alternative activation of macrophages in human perito neum: implications for peritoneal fibrosis. (PubMed id 21324976)1 BellA^n T....Bajo M.A. (2011)
  51. CCL2, CCL18 and sIL-4R in renal, meningeal and pulmon ary TB; a 2 year study of patients and contacts. (PubMed id 21251883)1 Mendez A....Rook G.A. (2011)
  52. Exploring CCL18, eczema severity and atopy. (PubMed id 21539615)1 Hon K.L....Leung T.F. (2011)
  53. Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants. (PubMed id 20608885)1 Kallankari H....Hallman M. (2010)
  54. Cardiovascular determinants and prognostic significan ce of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary arte ry disease. (PubMed id 20674579)1 De Sutter J....Van Damme J. (2010)
  55. Clinical utility of circulating matrix metalloprotein ase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11 ) as markers for diagnosis of epithelial ovarian cancer. (PubMed id 19937162)1 Zohny S.F. and Fayed S.T. (2010)
  56. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
  57. Attenuation of CXCR4 responses by CCL18 in acute lymp hocytic leukemia B cells. (PubMed id 20568229)1 Catusse J....Burger M. (2010)
  58. Expression of chemokine (C-C motif) ligand 18 in huma n macrophages and atherosclerotic plaques. (PubMed id 19036375)1 HAogg D.A....Svensson P.A. (2009)
  59. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (2009)
  60. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  61. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
  62. CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. (PubMed id 17469163)1 Prasse A....Muller-Quernheim J. (2007)
  63. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  64. Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid. (PubMed id 16984635)1 van Lieshout A.W....Radstake T.R. (2006)
  65. Involvement of CCL18 in allergic asthma. (PubMed id 16670340)1 de Nadai P....Tsicopoulos A. (2006)
  66. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  67. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. (PubMed id 15661937)1 Gunther C....Carballido J.M. (2005)
  68. PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia. (PubMed id 14578205)1 Struyf S....Laureys G. (2003)
  69. The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria. (PubMed id 12626578)1 Bruna-Romero O....Tsuji M. (2003)
  70. Unique regulation of CCL18 production by maturing dendritic cells. (PubMed id 12646652)1 Vulcano M....Sozzani S. (2003)
  71. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  72. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  73. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. (PubMed id 15784687)9 Schutyser E....Van Damme J. (2005)
  74. Pseudoexons and regulatory elements in the genomic sequence of the beta-chemokine, alternative macrophage activation-associated CC-chemokine (AMAC)-1. (PubMed id 10671296)9 Politz O....Goerdt S. (2000)
  75. Complex regulation of pulmonary inflammation and fibrosis by CCL18. (PubMed id 17569779)9 Pochetuhen K....Atamas S.P. (2007)
  76. Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis. (PubMed id 16142750)9 Kodera M....Sato S. (2005)
  77. The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes. (PubMed id 11207283)9 Lindhout E....Adema G.J. (2001)
  78. Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques. (PubMed id 10027395)9 Reape T.J....Groot P.H. (1999)
  79. Mycobacterium tuberculosis induces CCL18 expression i n human macrophages. (PubMed id 18959625)9 Ferrara G....Condos R. (2008)
  80. Mechanism of DNA segregation in prokaryotes: replicon pairing by parC of plasmid R1. (PubMed id 9671715)9 Jensen R.B....Gerdes K. (1998)
  81. PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblasts. (PubMed id 16601239)9 Luzina I.G....Atamas S.P. (2006)
  82. Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease. (PubMed id 16125420)9 Deegan P.B....Cox T.M. (2005)
  83. Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1. (PubMed id 9851514)9 Kodelja V....Goerdt S. (1998)
  84. [Evaluation of the chemokine variation in tears of contact lens wearers] (PubMed id 17025230)9 Iwasaki Y....Sawa M. (2006)
  85. C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. (PubMed id 10640766)9 Nibbs R.J....Graham G.J. (2000)
  86. Lactic acid bacteria enhance autophagic ability of mo nonuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. (PubMed id 20381647)9 Ghadimi D....Schrezenmeir J. (2010)
  87. Influence of measles vaccination on the progression of atopic dermatitis in infants. (PubMed id 17617807)9 Hennino A....Horvat B. (2007)
  88. Expression of C-C chemokines is associated with portal and periportal inflammation in the liver of patients with chronic hepatitis C. (PubMed id 10744077)9 Kusano F....Sato C. (2000)
  89. Circulating monocytes from systemic sclerosis patient s with interstitial lung disease show an enhanced profibrotic phenotype. (PubMed id 20404807)9 Mathai S.K....Herzog E.L. (2010)
  90. Alternatively activated and immunoregulatory monocyte s in human filarial infections. (PubMed id 19456233)9 Babu S....Nutman T.B. (2009)
  91. A pilot study to explore the usefulness of antibody array in childhood atopic dermatitis. (PubMed id 18507202)9 Hon K.L....Leung A.K. (2008)
  92. Clinical evaluation of biomarkers in Gaucher disease. (PubMed id 15895712)9 Deegan P.B. and Cox T.M. (2005)
  93. BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo. (PubMed id 11465112)9 Vissers J.L....Adema G.J. (2001)
  94. The divergent promoters mediating transcription of th e par locus of plasmid RP4 are subject to autoregulation. (PubMed id 1508044)9 Eberl L....Schwab H. (1992)
  95. New topoisomerase essential for chromosome segregation in E. coli. (PubMed id 2170028)9 Kato J....Suzuki H. (1990)
  96. CC chemokines as potential immunologic markers correl ated with clinical improvement of atopic dermatitis patients by immunotherapy. (PubMed id 19758316)9 Kwon Y.S....Lee K.H. (2010)
  97. Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes. (PubMed id 19404954)9 Luzina I.G....Atamas S.P. (2009)
  98. Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis. (PubMed id 19179488)9 Prasse A....MA1ller-Quernheim J. (2009)
  99. Interplay in the selection of fluoroquinolone resista nce and bacterial fitness. (PubMed id 19662169)9 Marcusson L.L....Hughes D. (2009)
  100. The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion. (PubMed id 18188522)9 Rodel F....Beuscher H.U. (2008)
  101. Distinct effect of CD40 and TNF-signaling on the chemokine/chemokine receptor expression and function of the human monocyte-derived dendritic cells. (PubMed id 18445342)9 Xia Y....Zhang X. (2008)
  102. Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. (PubMed id 17472813)9 Guttman-Yassky E....Krueger J.G. (2007)
  103. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). (PubMed id 16735693)9 Sironi M....Mantovani A. (2006)
  104. Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study. (PubMed id 17082335)9 Matsumoto K....Otsuka K. (2006)
  105. Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. (PubMed id 16671879)9 Sakai A....Ito K. (2006)
  106. Infiltration of activated dendritic cells and T cells in renal cell carcinoma following combined cytokine immunotherapy. (PubMed id 16115526)9 Verra N....Vyth-Dreese F. (2005)
  107. Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes. (PubMed id 15588486)9 Clark V.J. and Dean M. (2004)
  108. Phenotypical and functional characterization of clinical grade dendritic cells. (PubMed id 12218781)9 de Vries I.J....Figdor C.G. (2002)
  109. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. (PubMed id 11358988)9 Vissers J.L....Adema G.J. (2001)
  110. Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor. (PubMed id 9834229)9 Brossart P....Brugger W. (1998)
  111. Novel lymphocyte-specific CC chemokines and their receptors. (PubMed id 9365118)9 Yoshie O....Nomiyama H. (1997)
  112. Activation of human eosinophils and epidermal keratin ocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis. (PubMed id 20410259)9 Cheung P.F....Lam C.W. (2010)
  113. Transferable quinolone resistance in Vibrio cholerae. (PubMed id 19949057)9 Kim H.B....Hooper D.C. (2010)
  114. Molecular emm genotyping and antibiotic susceptibilit y of Streptococcus dysgalactiae subsp. equisimilis isolated from invasive and n on-invasive infections. (PubMed id 19745030)9 Sunaoshi K....Ubukata K. (2010)
  115. The effects of inhaled and oral corticosteroids on se rum inflammatory biomarkers in COPD: an exploratory study. (PubMed id 19465442)9 Man S.F....Sin D.D. (2009)
  116. Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell. (PubMed id 18803662)9 Lee H.J....Lee K.H. (2009)
  117. Remodeling phenotype of human subcutaneous adipose tissue macrophages. (PubMed id 18227385)9 Bourlier V....Bouloumie A. (2008)
  118. CD30 expression on CD1a+ and CD8+ cells in atopic dermatitis and correlation with disease severity. (PubMed id 18086588)9 Oflazoglu E....Gerber H.P. (2008)
  119. Plasma glucosylceramide and ceramide in type 1 Gaucher disease patients: correlations with disease severity and response to therapeutic intervention. (PubMed id 18155675)9 Groener J.E....Aerts J.M. (2008)
  120. [Alternatively activated macrophages/mononuclear phagocytes promote growth and invasion of breast cancer cell line SKBR3] (PubMed id 17545016)9 Guo J.J....Chen J.S. (2007)
  121. High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis. (PubMed id 17304652)9 Momohara S....Tomatsu T. (2007)
  122. Modulation of chemokines by staphylococcal superantigen in atopic dermatitis. (PubMed id 17369706)9 Homey B....Lauerma A. (2007)
  123. Short-term effect of miglustat in every day clinical use in treatment-naive or previously treated patients with type 1 Gaucher's disease. (PubMed id 16627252)9 Giraldo P....Pocovi M. (2006)
  124. Identification of genes involved in the suppression of antibody production from human peripheral blood lymphocytes. (PubMed id 16636465)9 Aiba Y....Shirahata S. (2006)
  125. Microarray and protein analysis of human pterygium. (PubMed id 16446702)9 John-Aryankalayil M....Carper D.A. (2006)
  126. Chemokine networks in atopic dermatitis: traffic signals of disease. (PubMed id 15967069)9 Pivarcsi A. and Homey B. (2005)
  127. Patterns of protein expression in infectious meningitis: a cerebrospinal fluid protein array analysis. (PubMed id 15885808)9 Kastenbauer S....Koedel U. (2005)
  128. Chemokines and gelatinases in the aqueous humor of patients with active uveitis. (PubMed id 15364222)9 Abu El-Asrar A.M....Geboes K. (2004)
  129. The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094)9 De Ceuninck F....Anract P. (2004)
  130. Transcriptional analysis of human peripheral blood mononuclear cells after influenza immunization. (PubMed id 15364265)9 Diaz-Mitoma F....Giulivi A. (2004)
  131. Emergence of levofloxacin-resistant pneumococci in im munocompromised adults after therapy for community-acquired pneumonia. (PubMed id 12884162)9 Anderson K.B....Low D.E. (2003)
  132. Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro. (PubMed id 12878509)9 Kuhn F....Cottagnoud P. (2003)
  133. Serum of patients with Behcet's disease induces classical (pro-inflammatory) activation of human macrophages in vitro. (PubMed id 12673080)9 Alpsoy E....Zouboulis C.h.C. (2003)
  134. High expression of chemokines Gro-alpha (CXCL-1), IL-8 (CXCL-8), and MCP-1 (CCL-2) in inflamed human corneas in vivo. (PubMed id 12796254)9 Spandau U.H....Kruse F.E. (2003)
  135. Cytokine regulation of pulmonary fibrosis in scleroderma. (PubMed id 14563355)9 Atamas S.P. and White B. (2003)
  136. Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. (PubMed id 11912289)9 Marvin K.W....Mitchell M.D. (2002)
  137. Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. (PubMed id 11830501)9 Tzachanis D....Boussiotis V.A. (2002)
  138. Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma. (PubMed id 12239608)9 Kimura T....Ushio Y. (2002)

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Entrez Gene: 6362 HGNC: 10616 AceView: CCL18 Ensembl:ENSG00000006074 euGenes: HUgn6362
ECgene: CCL18 Kegg: 6362 H-InvDB: CCL18

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PharmGKB entry for CCL18 Pharmacogenomics, SNPs, Pathways

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

 Antibodies for CCL18 (CCL18/PARC)   Browse Cell Culture Products  
 ELISAs for CCL18 (CCL18/PARC)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CCL18 (CCL18/PARC)  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Proteome Profiler Antibody Arrays for CCL18 (CCL18/PARC)  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCL18  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CCL18  
 OriGene MassSpec something-or-other for CCL18   OriGene clones in human, mouse for CCL18  
 OriGene qSTAR qPCR primer pairs in human, mouse for CCL18   OriGene Purified Protein for CCL18  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CCL18   OriGene Custom Protein Services for CCL18  

 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL18
 QIAGEN SeqTarget long-range PCR primers for resequencing CCL18
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL18
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL18
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL18
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL18
 GenScript Purified and Recombinant Proteins for CCL18 GenScript cDNA clones with any tag delivered in your preferred vector for CCL18
 GenScript Custom Assay Services for CCL18 GenScript Custom Superior Antibodies Services for CCL18
 GenScript Custom overexpressing Cell Line Services for CCL18 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in CCL18 promoter
 Search Chromatin IP Primers for CCL18
 RT2 qPCR Primer Assay in human, mouse / rat CCL18
 Search GNC Networks for CCL18
 SABiosciences PCR Arrays including human, mouse / rat CCL18
 Search Tocris compounds for CCL18
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 cDNA Clones for CCL18
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 CCL18 antibodies
 CCL18 proteins
 CCL18 lysates
 Antibodies for CCL18
 See all of Abcam's Antibodies, Kits and Proteins for CCL18
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for CCL18

 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for CCL18
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18
 SwitchGear 3'UTR luciferase reporter plasmids for CCL18
 SwitchGear Promoter luciferase reporter plasmids for CCL18
 ThermoFisher Antibodies for CCL18
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL18
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL18
 lentivirus for stable overexpression of CCL18
 lentivirus expression plasmids for stable overexpression of CCL18
 adenovirus for overexpression of CCL18
 LSBio Antibodies in human, mouse, rat for CCL18
Customized transgenic rodents for:
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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