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CCL18 Gene

protein-coding   GIFtS: 54
GCID: GC17P034391

Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated)

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 18,...)
(Previous symbol: SCYA18)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 18 (Pulmonary And
Activation-Regulated)1 2
     AMAC-12 3
SCYA181 2 3 5     DC-CK12 3
AMAC12 3 5     MIP-42 3
DCCK12 3 5     CC Chemokine PARC2 3
PARC2 3 5     CKb72
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And
Activation-Regulated1 2
     C-C Motif Chemokine 182
Alternative Macrophage Activation-Associated CC Chemokine 12 3     CC Chemokine Ligand 182
Dendritic Cell Chemokine 12 3     Chemokine (C-C), Dendritic2
Macrophage Inflammatory Protein 42 3     Small Inducible Cytokine A182
Pulmonary And Activation-Regulated Chemokine2 3     MIP43
Small-Inducible Cytokine A182 3     

External Ids:    HGNC: 106161   Entrez Gene: 63622   Ensembl: ENSG000000060747   OMIM: 6037575   UniProtKB: P557743   

Export aliases for CCL18 gene to outside databases

Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL18 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes.
This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It
may play a role in both humoral and cell-mediated immunity responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL18 Gene:
CCL18 (chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)) is a protein-coding gene. Diseases associated with CCL18 include septic arthritis, and interstitial lung disease. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
may play a role in both humoral and cell-mediated immunity responses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  NT_187614.1  NT_187661.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL18 gene promoter:
         POU2F2 (Oct-2.1)   TBP   AML1a   p53   POU2F2   YY1   POU2F2C   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL18 promoter sequence
   Search Chromatin IP Primers for CCL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL18 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

Start:
34,391,640 bp from pter      End:
34,399,392 bp from pter
Size:
7,753 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774 (See protein sequence)
Recommended Name: C-C motif chemokine 18 precursor  
Size: 89 amino acids; 9849 Da
Mass spectrometry: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396;
Mass spectrometry: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396;
Secondary accessions: B5BUM2 Q53X71

Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

Explore proteomics data for CCL18 at MOPED

Post-translational modifications: 

  • The Cys-30/Cys-54 disulfide bond is required for activity1
  • Modification sites at neXtProt

  • See CCL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002979.1  
    ENSEMBL proteins: 
     ENSP00000004921  

    CCL18 Human Recombinant Protein Products:

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    Novus Biologicals CCL18 Lysate
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    Browse Proteins at Cloud-Clone Corp.

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    CCL18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P55774

    ProtoNet protein and cluster: P55774

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL18_HUMAN, P55774
    Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in
    B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and
    activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus
    may play a role in both humoral and cell-mediated immunity responses
    Induction: Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10.
    Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in
    combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937
    cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008009chemokine activity IEA--
         
    CCL18 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL18

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    GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
    Sino Biological Human cDNA Clone for CCL18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL18_HUMAN, P55774: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CCL18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL18 About   (see all 8)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL18
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL18 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    2 Kegg Pathways  (Kegg details for CCL18):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL18 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL18: 
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CCL18 (P557741, 2, 3 ENSP000000049214) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1Q9UKR52, 3MINT-63888 I2D: score=6 
    TP53P046372, 3MINT-63883 I2D: score=6 
    UNC119Q134322, 3MINT-63885 I2D: score=6 
    CRMP1Q141942, 3MINT-63886 I2D: score=5 
    TLE1Q047242, 3MINT-63884 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS9192897
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007154cell communication TAS9192897
    GO:0007165signal transduction TAS9233607

    CCL18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL18

    10 Novoseek inferred chemical compound relationships for CCL18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 79.7 9 9365118 (2), 11358988 (2), 11159181 (1), 18086588 (1) (see all 6)
    larc 75.2 6 9365118 (2), 10027395 (2), 12239608 (1)
    ccl3 71 5 16773571 (2), 17369706 (1), 15588486 (1)
    rantes 54.8 9 10744077 (4), 17909104 (2), 10559506 (1), 11576227 (1) (see all 5)
    ofloxacin 25.8 2 12878509 (1), 19745030 (1)
    ccl4 18.3 3 16773571 (2), 17369706 (1)
    vegf 3.95 2 16671879 (1), 17082335 (1)
    calcium 0 2 10087196 (1), 16601239 (1)
    alanine 0 1 10744077 (1)
    dexamethasone 0 3 12161279 (2), 12673080 (1)



    CCL18 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCL18 gene: 
    NM_002988.2  

    Unigene Cluster for CCL18:

    Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
    Hs.143961  [show with all ESTs]
    Unigene Representative Sequence: Y13710
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000004921(uc002hku.3) ENST00000586857
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB000221.1 AB451458.1 BC069700.1 BC096124.3 BC096125.3 BC096126.1 BC096127.1 CR407660.1 
    Y13710.1 

    2 DOTS entries:

    DT.314426  DT.100748759 

    Selected AceView cDNA sequences (see all 73):

    AA425047 CA440845 AA296912 BM991019 CA435401 CR407660 BX116770 AA729801 
    AW264712 AB000221 NM_002988 BQ025756 CA428280 BU617136 BQ447593 AI969253 
    AI828910 N44551 AU100459 BC069700 CD366385 AI299310 BQ772229 BU617575 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAATCAG
    CCL18 Expression
    About this image

    CCL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143961

    UniProtKB/Swiss-Prot: CCL18_HUMAN, P55774
    Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present
    in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood
    monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a
    prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and
    in ovarian carcinoma ascitic fluid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL18: 
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL18 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CCLI86
    Gallus gallus chemokine ah221 (LOC417536), mRNA.
    38(a)
    many ↔ many
    19(4812218-4813843)
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    31(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378
            Species with no ortholog for CCL18

    ENSEMBL Gene Tree for CCL18 (if available)
    TreeFam Gene Tree for CCL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL18 gene
    CCL152  CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  
    CCL52  CCL232  CCL3L32  CCL42  CCL15-CCL142  
    Selected SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):
    CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4
    CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15
    CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

    CCL18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for CCL18    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355110821,2
    C--34395689(+) TTTTA-/AAAAAA 1 -- int10--------
    rs3770536801,2
    ----34395745(+) TTTTT-/TCAGGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CCL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833427CNV Loss17160897
    dgv120e55CNV Gain17911159
    nsv833424CNV Gain17160897
    nsv428340CNV Gain18775914
    dgv945e1CNV Complex17122850
    dgv946e1CNV Complex17122850
    dgv947e1CNV Complex17122850
    dgv948e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL18
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603757    OMIM disorders: --

    Selected diseases for CCL18 (see all 58):    About MalaCards
    septic arthritis    interstitial lung disease    allergic asthma    pterygium
    angina pectoris    atopic dermatitis    niemann-pick disease    pick's disease
    pulmonary fibrosis    gaucher's disease    human t-cell leukemia virus type 1    idiopathic interstitial pneumonia
    idiopathic pulmonary fibrosis    pneumonia    skin disease    measles
    influenza    dermatitis    sarcoidosis    psoriasis

    2 diseases from the University of Copenhagen DISEASES database for CCL18:
    Gaucher's disease     Atopic dermatitis

    CCL18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CCL18 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaucher disease 66 5 16125420 (2), 15702402 (2), 15895712 (1)
    dermatitis atopic 58.5 5 15494534 (2), 15967069 (1), 17369706 (1), 17979978 (1)
    pulmonary fibrosis 53.6 5 12805086 (2), 17569779 (1), 16142750 (1)
    dermatitis 38.7 1 15494534 (1)
    skin diseases 35.6 2 15784687 (1), 15494534 (1)
    necrosis 30.9 10 17545016 (1), 16671879 (1), 17569779 (1), 10569653 (1) (see all 8)
    inflammation 24.3 6 17569779 (1), 19017877 (1), 19958819 (1)
    sarcoidosis 21.2 5 19808030 (4), 12161279 (1)
    tumors 7.61 10 10961902 (1), 17545016 (1), 16671879 (1), 17569779 (1) (see all 8)
    atherosclerotic plaque 7.31 2 10027395 (2)

    Genetic Association Database (GAD): CCL18
    Human Genome Epidemiology (HuGE) Navigator: CCL18 (12 documents)

    Export disorders for CCL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCL18 gene, integrated from 10 sources (see all 154) (see top 10):
    (articles sorted by number of sources associating them with CCL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)1, 2, 3, 9 Hieshima K.... Nomiyama H. (J. Immunol. 1997)
    2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)1, 2, 3, 9 Tasaki Y.... Nomiyama H. (Genomics 1999)
    3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)1, 2, 9 Schutyser E.... Van Damme J. (Eur. J. Immunol. 2001)
    4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)1, 2, 9 Guan P.... McColl S.R. (Genomics 1999)
    5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)1, 2, 9 Adema G.J....Figdor C.G. (Nature 1997)
    6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)1, 2, 9 Kodelja V.... Goerdt S. (J. Immunol. 1998)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    11. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    12. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    14. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. (PubMed id 11978786)1, 2 Schutyser E.... Van Damme J. (J. Biol. Chem. 2002)
    15. The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)1, 2 Wells T.N.C. and Peitsch M.C. (J. Leukoc. Biol. 1997)
    16. Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. (PubMed id 12716654)1, 9 Schraufstatter I....DiScipio R.G. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
    17. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. (PubMed id 15494534)1, 9 Pivarcsi A....Homey B. (J. Immunol. 2004)
    18. Increased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients. (PubMed id 17979978)1, 9 Park C.O....Lee K.H. (Exp. Dermatol. 2008)
    19. Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis. (PubMed id 19808030)1, 9 Boot R.G....Aerts J.M. ( international journal of clinical chemistry 2010)
    20. Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis. (PubMed id 17875202)1, 9 Auer J....Beuscher H.U. (amp 2007)
    21. CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. (PubMed id 17909104)1, 9 Kraaijeveld A.O....Biessen E.A. (Circulation 2007)
    22. CCL18: a urinary marker of Gaucher cell burden in Gaucher patients. (PubMed id 16736095)1, 9 Boot R.G....Aerts J.M. (J. Inherit. Metab. Dis. 2006)
    23. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease. (PubMed id 15702402)1, 9 Brinkman J....Aerts J.M. (J. Inherit. Metab. Dis. 2005)
    24. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. (PubMed id 12805086)1, 9 Atamas S.P....White B. (Am. J. Respir. Cell Mol. Biol. 2003)
    25. Expression of the chemokine PARC mRNA in bronchoalveolar cells of patients with sarcoidosis. (PubMed id 12161279)1, 9 Mrazek F....Petrek M. (Immunol. Lett. 2002)
    26. Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum. (PubMed id 19017877)1, 9 Kim H.B....Kita H. (Chest 2009)
    27. CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders. (PubMed id 19958819)1, 9 Chang C.Y....Wu C.H. (Neuroscience 2010)
    28. Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia virus type 1-associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis. (PubMed id 17900259)1, 9 Shimizu K....Ohshima K. (Cancer Sci. 2007)
    29. Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. (PubMed id 16773571)1, 9 Modi W.S....Winkler C. (Am. J. Hum. Genet. 2006)
    30. CCL18 production is decreased in alveolar macrophages from cigarette smokers. (PubMed id 19357939)1, 9 Kollert F....Prasse A. (Inflammation 2009)
    31. Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications. (PubMed id 17181634)1, 9 Plager D.A....Pittelkow M.R. (Exp. Dermatol. 2007)
    32. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. (PubMed id 16415274)1, 9 Prasse A....Zissel G. (Am. J. Respir. Crit. Care Med. 2006)
    33. Genome-wide association study of lung function phenotypes in a founder population. (PubMed id 23932459)1 Yao T.C....Ober C. (J. Allergy Clin. Immunol. 2014)
    34. Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3I^/Snail signalling pathway. (PubMed id 24001613)1 Zhang B....Qi Y. (Eur. J. Cancer 2013)
    35. The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity. (PubMed id 23742785)2 Legendre B....Lassalle P. (Cytokine 2013)
    36. CC-chemokine ligand 18 induces epithelial to mesenchymal transition in lung cancer A549 cells and elevates the invasive potential. (PubMed id 23349697)1 Ploenes T....Zissel G. (PLoS ONE 2013)
    37. CCL18 as an independent favorable prognostic biomarker in patients with colorectal cancer. (PubMed id 23433718)1 Yuan R....Lan P. (J. Surg. Res. 2013)
    38. Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma. (PubMed id 23331560)1 Gavala M.L....Jarjour N.N. (Clin. Exp. Allergy 2013)
    39. Role of CCL18 in asthma and lung immunity. (PubMed id 23786278)1 Tsicopoulos A....Chenivesse C. (Clin. Exp. Allergy 2013)
    40. Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? (PubMed id 23588945)1 Elhaj M....Assassi S. (J. Rheumatol. 2013)
    41. Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis. (PubMed id 22404649)1 Miyagaki T....Sato S. (J Eur Acad Dermatol Venereol 2013)
    42. Identification of human CCR8 as a CCL18 receptor. (PubMed id 23999500)1 Islam S.A....Luster A.D. (J. Exp. Med. 2013)
    43. Gene expression profiles in paired gingival biopsies from periodontitis-affected and healthy tissues revealed by massively parallel sequencing. (PubMed id 23029519)1 Davanian H....Yucel-Lindberg T. (PLoS ONE 2012)
    44. CCL18 in a multiplex urine-based assay for the detection of bladder cancer. (PubMed id 22629457)1 Urquidi V....Goodison S. (PLoS ONE 2012)
    45. Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity. (PubMed id 23102918)1 Bellinghausen I....Saloga J. (J. Allergy Clin. Immunol. 2012)
    46. Serum level of CC-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas. (PubMed id 22848587)1 PlAPnes T....Zissel G. (PLoS ONE 2012)
    47. The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum. (PubMed id 22117697)1 Schraufstatter I.U....Discipio R.G. (Immunology 2012)
    48. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. (PubMed id 21943944)1 Peterson S....Kato A. (J. Allergy Clin. Immunol. 2012)
    49. Chemokines CCL3/MIP1I+, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes. (PubMed id 23029252)1 de Jager S.C....Biessen E.A. (PLoS ONE 2012)
    50. CCL18 -- potential biomarker of fibroinflammatory activity in chronic periaortitis. (PubMed id 22589264)1 Kollert F....Warnatz K. (J. Rheumatol. 2012)
    51. Pulmonary CCL18 recruits human regulatory T cells. (PubMed id 22649201)1 Chenivesse C....Tsicopoulos A. (J. Immunol. 2012)
    52. Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls. (PubMed id 22203932)1 NariALa D....Anghel A. (Rom J Morphol Embryol 2011)
    53. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. (PubMed id 21928244)1 Wang Q....Li L. (Int. J. Biol. Markers 2011)
    54. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. (PubMed id 21481794)1 Chen J....Song E. (Cancer Cell 2011)
    55. Serum CC chemokine ligand-18 predicts lung disease worsening in systemic sclerosis. (PubMed id 21778167)1 Tiev K.P....Dinh-Xuan A.T. (Eur. Respir. J. 2011)
    56. Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis. (PubMed id 21324976)1 BellA^n T....Bajo M.A. (Nephrol. Dial. Transplant. 2011)
    57. CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts. (PubMed id 21251883)1 Mendez A....Rook G.A. (Tuberculosis (Edinb) 2011)
    58. Exploring CCL18, eczema severity and atopy. (PubMed id 21539615)1 Hon K.L....Leung T.F. (Pediatr Allergy Immunol 2011)
    59. Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants. (PubMed id 20608885)1 Kallankari H....Hallman M. (Ann. Med. 2010)
    60. Cardiovascular determinants and prognostic significance of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary artery disease. (PubMed id 20674579)1 De Sutter J....Van Damme J. (J. Mol. Cell. Cardiol. 2010)
    61. Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer. (PubMed id 19937162)1 Zohny S.F. and Fayed S.T. (Med. Oncol. 2010)
    62. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    63. Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells. (PubMed id 20568229)1 Catusse J....Burger M. (J. Cell. Physiol. 2010)
    64. Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaques. (PubMed id 19036375)1 HAogg D.A....Svensson P.A. (Atherosclerosis 2009)
    65. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)
    66. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    67. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (Nat. Methods 2008)
    68. CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. (PubMed id 17469163)1 Prasse A....MA1ller-Quernheim J. (Arthritis Rheum. 2007)
    69. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    70. Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid. (PubMed id 16984635)1 van Lieshout A.W....Radstake T.R. (BMC Immunol. 2006)
    71. Involvement of CCL18 in allergic asthma. (PubMed id 16670340)1 de NadaA^ P....Tsicopoulos A. (J. Immunol. 2006)
    72. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    73. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. (PubMed id 15661937)1 GA1nther C....Carballido J.M. (J. Immunol. 2005)
    74. PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia. (PubMed id 14578205)1 Struyf S....Laureys G. (Am. J. Pathol. 2003)
    75. The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria. (PubMed id 12626578)1 Bruna-Romero O....Tsuji M. (J. Immunol. 2003)
    76. Unique regulation of CCL18 production by maturing dendritic cells. (PubMed id 12646652)1 Vulcano M....Sozzani S. (J. Immunol. 2003)
    77. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    78. (PubMed id )2 
    79. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. (PubMed id 15784687)9 Schutyser E....Van Damme J. (J. Leukoc. Biol. 2005)
    80. Pseudoexons and regulatory elements in the genomic sequence of the beta-chemokine, alternative macrophage activation-associated CC-chemokine (AMAC)-1. (PubMed id 10671296)9 Politz O....Goerdt S. (Cytokine 2000)
    81. Complex regulation of pulmonary inflammation and fibrosis by CCL18. (PubMed id 17569779)9 Pochetuhen K....Atamas S.P. (Am. J. Pathol. 2007)
    82. Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis. (PubMed id 16142750)9 Kodera M....Sato S. (Arthritis Rheum. 2005)
    83. The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes. (PubMed id 11207283)9 Lindhout E....Adema G.J. (J. Immunol. 2001)
    84. Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques. (PubMed id 10027395)9 Reape T.J....Groot P.H. (Am. J. Pathol. 1999)
    85. Mycobacterium tuberculosis induces CCL18 expression in human macrophages. (PubMed id 18959625)9 Ferrara G....Condos R. (Scand. J. Immunol. 2008)
    86. Mechanism of DNA segregation in prokaryotes: replicon pairing by parC of plasmid R1. (PubMed id 9671715)9 Jensen R.B....Gerdes K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    87. PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblasts. (PubMed id 16601239)9 Luzina I.G....Atamas S.P. (Am. J. Respir. Cell Mol. Biol. 2006)
    88. Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease. (PubMed id 16125420)9 Deegan P.B....Cox T.M. (amp 2005)
    89. Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1. (PubMed id 9851514)9 Kodelja V....Goerdt S. (Res. Immunol. 1998)
    90. [Evaluation of the chemokine variation in tears of contact lens wearers]. (PubMed id 17025230)9 Iwasaki Y....Sawa M. (Nippon Ganka Gakkai Zasshi 2006)
    91. C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. (PubMed id 10640766)9 Nibbs R.J....Graham G.J. (J. Immunol. 2000)
    92. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. (PubMed id 20381647)9 Ghadimi D....Schrezenmeir J. (Int. Immunopharmacol. 2010)
    93. Influence of measles vaccination on the progression of atopic dermatitis in infants. (PubMed id 17617807)9 Hennino A....Horvat B. (Pediatr Allergy Immunol 2007)
    94. Expression of C-C chemokines is associated with portal and periportal inflammation in the liver of patients with chronic hepatitis C. (PubMed id 10744077)9 Kusano F....Sato C. ( a journal of technical methods and pathology 2000)
    95. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. (PubMed id 20404807)9 Mathai S.K....Herzog E.L. ( a journal of technical methods and pathology 2010)
    96. Alternatively activated and immunoregulatory monocytes in human filarial infections. (PubMed id 19456233)9 Babu S....Nutman T.B. (J. Infect. Dis. 2009)
    97. A pilot study to explore the usefulness of antibody array in childhood atopic dermatitis. (PubMed id 18507202)9 Hon K.L....Leung A.K. (J Natl Med Assoc 2008)
    98. Clinical evaluation of biomarkers in Gaucher disease. (PubMed id 15895712)9 Deegan P.B. and Cox T.M. (Acta Paediatr Suppl 2005)
    99. BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo. (PubMed id 11465112)9 Vissers J.L....Adema G.J. (Eur. J. Immunol. 2001)
    100. The divergent promoters mediating transcription of the par locus of plasmid RP4 are subject to autoregulation. (PubMed id 1508044)9 Eberl L....Schwab H. (Mol. Microbiol. 1992)
    101. New topoisomerase essential for chromosome segregation in E. coli. (PubMed id 2170028)9 Kato J....Suzuki H. (Cell 1990)
    102. CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy. (PubMed id 19758316)9 Kwon Y.S....Lee K.H. (Exp. Dermatol. 2010)
    103. Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes. (PubMed id 19404954)9 Luzina I.G....Atamas S.P. (Arthritis Rheum. 2009)
    104. Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis. (PubMed id 19179488)9 Prasse A....MA1ller-Quernheim J. (Am. J. Respir. Crit. Care Med. 2009)
    105. Interplay in the selection of fluoroquinolone resistance and bacterial fitness. (PubMed id 19662169)9 Marcusson L.L....Hughes D. (PLoS Pathog. 2009)
    106. The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion. (PubMed id 18188522)9 RAPdel F....Beuscher H.U. (Strahlenther Onkol 2008)
    107. Distinct effect of CD40 and TNF-signaling on the chemokine/chemokine receptor expression and function of the human monocyte-derived dendritic cells. (PubMed id 18445342)9 Xia Y....Zhang X. (amp 2008)
    108. Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. (PubMed id 17472813)9 Guttman-Yassky E....Krueger J.G. (J. Allergy Clin. Immunol. 2007)
    109. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). (PubMed id 16735693)9 Sironi M....Mantovani A. (J. Leukoc. Biol. 2006)
    110. Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study. (PubMed id 17082335)9 Matsumoto K....Otsuka K. (Dentomaxillofac Radiol 2006)
    111. Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. (PubMed id 16671879)9 Sakai A....Ito K. (J. Periodontol. 2006)
    112. Infiltration of activated dendritic cells and T cells in renal cell carcinoma following combined cytokine immunotherapy. (PubMed id 16115526)9 Verra N....Vyth-Dreese F. (Eur. Urol. 2005)
    113. Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes. (PubMed id 15588486)9 Clark V.J. and Dean M. (Hum. Genomics 2004)
    114. Phenotypical and functional characterization of clinical grade dendritic cells. (PubMed id 12218781)9 de Vries I.J....Figdor C.G. (J. Immunother. 2002)
    115. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. (PubMed id 11358988)9 Vissers J.L....Adema G.J. (J. Leukoc. Biol. 2001)
    116. Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor. (PubMed id 9834229)9 Brossart P....Brugger W. (Blood 1998)
    117. Novel lymphocyte-specific CC chemokines and their receptors. (PubMed id 9365118)9 Yoshie O....Nomiyama H. (J. Leukoc. Biol. 1997)
    118. Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis. (PubMed id 20410259)9 Cheung P.F....Lam C.W. (Int. Immunol. 2010)
    119. Transferable quinolone resistance in Vibrio cholerae. (PubMed id 19949057)9 Kim H.B....Hooper D.C. (Antimicrob. Agents Chemother. 2010)
    120. Molecular emm genotyping and antibiotic susceptibility of Streptococcus dysgalactiae subsp. equisimilis isolated from invasive and non-invasive infections. (PubMed id 19745030)9 Sunaoshi K....Ubukata K. (J. Med. Microbiol. 2010)
    121. The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study. (PubMed id 19465442)9 Man S.F....Sin D.D. (Ther Adv Respir Dis 2009)
    122. Corticotropin-releasing factor decreases IL-18 in the monocyte-derived dendritic cell. (PubMed id 18803662)9 Lee H.J....Lee K.H. (Exp. Dermatol. 2009)
    123. Remodeling phenotype of human subcutaneous adipose tissue macrophages. (PubMed id 18227385)9 Bourlier V....BouloumiAc A. (Circulation 2008)
    124. CD30 expression on CD1a+ and CD8+ cells in atopic dermatitis and correlation with disease severity. (PubMed id 18086588)9 Oflazoglu E....Gerber H.P. (Eur J Dermatol 2008)
    125. Plasma glucosylceramide and ceramide in type 1 Gaucher disease patients: correlations with disease severity and response to therapeutic intervention. (PubMed id 18155675)9 Groener J.E....Aerts J.M. (Biochim. Biophys. Acta 2008)
    126. [Alternatively activated macrophages/mononuclear phagocytes promote growth and invasion of breast cancer cell line SKBR3]. (PubMed id 17545016)9 Guo J.J....Chen J.S. (Nan Fang Yi Ke Da Xue Xue Bao 2007)
    127. High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis. (PubMed id 17304652)9 Momohara S....Tomatsu T. (J. Rheumatol. 2007)
    128. Modulation of chemokines by staphylococcal superantigen in atopic dermatitis. (PubMed id 17369706)9 Homey B....Lauerma A. (Chem Immunol Allergy 2007)
    129. Short-term effect of miglustat in every day clinical use in treatment-naA^ve or previously treated patients with type 1 Gaucher's disease. (PubMed id 16627252)9 Giraldo P....Pocovi M. (Haematologica 2006)
    130. Identification of genes involved in the suppression of antibody production from human peripheral blood lymphocytes. (PubMed id 16636465)9 Aiba Y....Shirahata S. (Biosci. Biotechnol. Biochem. 2006)
    131. Microarray and protein analysis of human pterygium. (PubMed id 16446702)9 John-Aryankalayil M....Carper D.A. (Mol. Vis. 2006)
    132. Chemokine networks in atopic dermatitis: traffic signals of disease. (PubMed id 15967069)9 Pivarcsi A. and Homey B. (Curr Allergy Asthma Rep 2005)
    133. Patterns of protein expression in infectious meningitis: a cerebrospinal fluid protein array analysis. (PubMed id 15885808)9 Kastenbauer S....Koedel U. (J. Neuroimmunol. 2005)
    134. Chemokines and gelatinases in the aqueous humor of patients with active uveitis. (PubMed id 15364222)9 Abu El-Asrar A.M....Geboes K. (Am. J. Ophthalmol. 2004)
    135. The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094)9 De Ceuninck F....Anract P. (Biochem. Biophys. Res. Commun. 2004)
    136. Transcriptional analysis of human peripheral blood mononuclear cells after influenza immunization. (PubMed id 15364265)9 Diaz-Mitoma F....Giulivi A. (J. Clin. Virol. 2004)
    137. Emergence of levofloxacin-resistant pneumococci in immunocompromised adults after therapy for community-acquired pneumonia. (PubMed id 12884162)9 Anderson K.B....Low D.E. (Clin. Infect. Dis. 2003)
    138. Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro. (PubMed id 12878509)9 KA1hn F....Cottagnoud P. (Antimicrob. Agents Chemother. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6362 HGNC: 10616 AceView: CCL18 Ensembl:ENSG00000006074 euGenes: HUgn6362
    ECgene: CCL18 Kegg: 6362 H-InvDB: CCL18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL18 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL18

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL18 gene:
    Search GeneIP for patents involving CCL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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