CCL18 Gene

Aliases
for CCL18 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17P034161 GC17P036427 GC17P034537 GC17P031415 GC17P030576

Summaries
for CCL18 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CCL18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  NT_187661.1  

SwitchGear Promoter luciferase reporter plasmid: CCL18 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL18

CCL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034391:  view genomic region     (about GC identifiers)

Proteins
for CCL18 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CCL18: NX_P55774

Explore proteomics data for CCL18 at MOPED

Post-translational modifications: 

CCL18 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL18 (CCL18/PARC)
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	OriGene Purified Protein for CCL18 OriGene Protein Over-expression Lysate for CCL18 OriGene MassSpec for CCL18 OriGene Custom Protein Services for CCL18
	GenScript Purified and Recombinant Proteins for CCL18
	Novus Biologicals CCL18 Proteins Novus Biologicals CCL18 Lysate
	Sino Biological Recombinant Protein for CCL18 Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CCL18
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CCL18
	GeneTex Proteins for CCL18:                       MIP-4 Recombinant Protein (Active) (GTX48368-PRO)
	antibodies-online proteins for CCL18 (2 products)
	antibodies-online peptides for CCL18

CCL18 Antibody Products:

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	R&D Systems Antibodies for CCL18 (CCL18/PARC)
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	Novus Biologicals CCL18 Antibodies
	Search for Antibodies for CCL18 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CCL18
	antibodies-online antibodies for CCL18 (39 products)

CCL18 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCL18
	R&D Systems ELISAs for CCL18 (CCL18/PARC)         (see all)
	GenScript Custom Assay Services for CCL18
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CCL18
	antibodies-online kits for CCL18 (10 products)

Domains /
Families
for CCL18 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P55774

Find genes that share domains with CCL18           About GenesLikeMe

Function
for CCL18 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for CCL18

miRNA Products:		Block miRNA regulation of human, mouse, rat CCL18 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CCL18
		SwitchGear 3'UTR luciferase reporter plasmid: CCL18 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCL18
		Predesigned siRNA for gene silencing in human, mouse, rat CCL18

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CCL18

Clone Products:		OriGene clones in human, mouse for CCL18 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL18 (NM_002988)
		Sino Biological Human cDNA Clone for CCL18
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL18
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL18

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL18
		Browse ESI BIO Cell Lines and PureStem Progenitors for CCL18

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

Localization
for CCL18 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CCL18 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CCL18 About   (see all 8)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	PEDF Induced Signaling	MIF Regulation of Innate Immune Cells 0.94 NFAT Signaling and Lymphocyte Interactions 0.57 MIF Mediated Glucocorticoid Regulation 0.94 PGC1Alpha Pathway 0.51 PEDF Induced Signaling 0.73 STAT3 Pathway 0.47 all-trans-Retinoic Acid Signaling in Brain 0.71 Endothelin-1 Signaling Pathway 0.46
2	Chemokine Signaling	Chemokine Signaling 0.33 Chemokine signaling pathway 0.33
3	TGF-Beta Pathway	TGF-Beta Pathway 0.60 JNK Pathway 0.51 MAPK Family Pathway 0.60 Regulation of eIF4 and p70S6K 0.43 JAK-STAT Pathway 0.57 SOCS Pathway 0.40
4	Akt Signaling	Akt Signaling 0.60 Tec Kinases Signaling 0.55 p38 Signaling 0.60
5	ERK Signaling	ERK Signaling 0.61 Molecular Mechanisms of Cancer 0.51 Rho Family GTPases 0.61

1 R&D Systems Pathway for CCL18

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL18

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 Kegg Pathways  (Kegg details for CCL18)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for CCL18 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CCL18 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CCL18 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATCAATCAG

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CCL18
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL18
		QuantiTect SYBR Green Assays in human, mouse, rat CCL18
		QuantiFast Probe-based Assays in human, mouse, rat CCL18

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL18

Orthologs
for CCL18 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CCL18 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CCL18 gene

CCL15²  CCL16²  CCL14²  CCL4L1²  CCL3L1²  CCL4L2²  CCL26²  CCL3²  

CCL5²  CCL23²  CCL3L3²  CCL4²  CCL15-CCL14²  

Selected SIMAP similar genes for CCL18 using alignment to 1 protein entry:     CCL18_HUMAN(see all similar genes):

CCL14    CCL3    CCL3L1    CCL3L3    CCL23    CCL4

CCL4L2    LOC728835    CCL4L1    CCL2    CCL13    CCL15

CCL16    CCL24    CCL5    CX3CL1    CCL26    CCL7

Find genes that share paralogs with CCL18           About GenesLikeMe

Genomic Variants
for CCL18 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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2 SNPs for CCL18    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs355110821,2	C	--	34395689(+)	TTTTA-/AAAAAA	1	--	int1		0	--	--	--	--
rs3770536801,2	--	--	34395745(+)	TTTTT-/TCAGGT	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL18 (34391640 - 34399392 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for CCL18:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv833427	CNV	Loss	17160897
dgv120e55	CNV	Gain	17911159
nsv833424	CNV	Gain	17160897
nsv428340	CNV	Gain	18775914
dgv945e1	CNV	Complex	17122850
dgv946e1	CNV	Complex	17122850
dgv947e1	CNV	Complex	17122850
dgv948e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CCL18

DNA2.0 Custom Variant and Variant Library Synthesis for CCL18

Disorders / Diseases
for CCL18 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

4 diseases for CCL18

Selected Novoseek inferred disease relationships for CCL18 gene (see all 15)    About this table

Publications
for CCL18 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCL18 gene, integrated from 10 sources (see all 154) (see top 10): (articles sorted by number of sources associating them with CCL18)

Utopia: connect your pdf to the dynamic world of online information

1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PubMed id 9233607)^{1, 2, 3, 9} Hieshima K.... Nomiyama H. (J. Immunol. 1997)
2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PubMed id 10049593)^{1, 2, 3, 9} Tasaki Y.... Nomiyama H. (Genomics 1999)
3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PubMed id 11745396)^{1, 2, 9} Schutyser E.... Van Damme J. (Eur. J. Immunol. 2001)
4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PubMed id 10087196)^{1, 2, 9} Guan P.... McColl S.R. (Genomics 1999)
5. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. (PubMed id 9192897)^{1, 2, 9} Adema G.J....Figdor C.G. (Nature 1997)
6. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PubMed id 9570561)^{1, 2, 9} Kodelja V.... Goerdt S. (J. Immunol. 1998)
7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
11. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
12. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)
13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
14. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. (PubMed id 11978786)^{1, 2} Schutyser E.... Van Damme J. (J. Biol. Chem. 2002)
15. The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)^{1, 2} Wells T.N.C. and Peitsch M.C. (J. Leukoc. Biol. 1997)
16. Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. (PubMed id 12716654)^{1, 9} Schraufstatter I....DiScipio R.G. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
17. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. (PubMed id 15494534)^{1, 9} Pivarcsi A....Homey B. (J. Immunol. 2004)
18. Increased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients. (PubMed id 17979978)^{1, 9} Park C.O....Lee K.H. (Exp. Dermatol. 2008)
19. Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis. (PubMed id 19808030)^{1, 9} Boot R.G....Aerts J.M. ( international journal of clinical chemistry 2010)
20. Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis. (PubMed id 17875202)^{1, 9} Auer J....Beuscher H.U. (amp 2007)
21. CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. (PubMed id 17909104)^{1, 9} Kraaijeveld A.O....Biessen E.A. (Circulation 2007)
22. CCL18: a urinary marker of Gaucher cell burden in Gaucher patients. (PubMed id 16736095)^{1, 9} Boot R.G....Aerts J.M. (J. Inherit. Metab. Dis. 2006)
23. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease. (PubMed id 15702402)^{1, 9} Brinkman J....Aerts J.M. (J. Inherit. Metab. Dis. 2005)
24. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. (PubMed id 12805086)^{1, 9} Atamas S.P....White B. (Am. J. Respir. Cell Mol. Biol. 2003)
25. Expression of the chemokine PARC mRNA in bronchoalveolar cells of patients with sarcoidosis. (PubMed id 12161279)^{1, 9} Mrazek F....Petrek M. (Immunol. Lett. 2002)
26. Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum. (PubMed id 19017877)^{1, 9} Kim H.B....Kita H. (Chest 2009)
27. CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders. (PubMed id 19958819)^{1, 9} Chang C.Y....Wu C.H. (Neuroscience 2010)
28. Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia virus type 1-associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis. (PubMed id 17900259)^{1, 9} Shimizu K....Ohshima K. (Cancer Sci. 2007)
29. Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. (PubMed id 16773571)^{1, 9} Modi W.S....Winkler C. (Am. J. Hum. Genet. 2006)
30. CCL18 production is decreased in alveolar macrophages from cigarette smokers. (PubMed id 19357939)^{1, 9} Kollert F....Prasse A. (Inflammation 2009)
31. Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications. (PubMed id 17181634)^{1, 9} Plager D.A....Pittelkow M.R. (Exp. Dermatol. 2007)
32. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. (PubMed id 16415274)^{1, 9} Prasse A....Zissel G. (Am. J. Respir. Crit. Care Med. 2006)
33. Genome-wide association study of lung function phenotypes in a founder population. (PubMed id 23932459)¹ Yao T.C....Ober C. (J. Allergy Clin. Immunol. 2014)
34. Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3I^/Snail signalling pathway. (PubMed id 24001613)¹ Zhang B....Qi Y. (Eur. J. Cancer 2013)
35. The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity. (PubMed id 23742785)² Legendre B....Lassalle P. (Cytokine 2013)
36. CC-chemokine ligand 18 induces epithelial to mesenchymal transition in lung cancer A549 cells and elevates the invasive potential. (PubMed id 23349697)¹ Ploenes T....Zissel G. (PLoS ONE 2013)
37. CCL18 as an independent favorable prognostic biomarker in patients with colorectal cancer. (PubMed id 23433718)¹ Yuan R....Lan P. (J. Surg. Res. 2013)
38. Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma. (PubMed id 23331560)¹ Gavala M.L....Jarjour N.N. (Clin. Exp. Allergy 2013)
39. Role of CCL18 in asthma and lung immunity. (PubMed id 23786278)¹ Tsicopoulos A....Chenivesse C. (Clin. Exp. Allergy 2013)
40. Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? (PubMed id 23588945)¹ Elhaj M....Assassi S. (J. Rheumatol. 2013)
41. Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis. (PubMed id 22404649)¹ Miyagaki T....Sato S. (J Eur Acad Dermatol Venereol 2013)
42. Identification of human CCR8 as a CCL18 receptor. (PubMed id 23999500)¹ Islam S.A....Luster A.D. (J. Exp. Med. 2013)
43. Gene expression profiles in paired gingival biopsies from periodontitis-affected and healthy tissues revealed by massively parallel sequencing. (PubMed id 23029519)¹ Davanian H....Yucel-Lindberg T. (PLoS ONE 2012)
44. CCL18 in a multiplex urine-based assay for the detection of bladder cancer. (PubMed id 22629457)¹ Urquidi V....Goodison S. (PLoS ONE 2012)
45. Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity. (PubMed id 23102918)¹ Bellinghausen I....Saloga J. (J. Allergy Clin. Immunol. 2012)
46. Serum level of CC-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas. (PubMed id 22848587)¹ PlAPnes T....Zissel G. (PLoS ONE 2012)
47. The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum. (PubMed id 22117697)¹ Schraufstatter I.U....Discipio R.G. (Immunology 2012)
48. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. (PubMed id 21943944)¹ Peterson S....Kato A. (J. Allergy Clin. Immunol. 2012)
49. Chemokines CCL3/MIP1I+, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes. (PubMed id 23029252)¹ de Jager S.C....Biessen E.A. (PLoS ONE 2012)
50. CCL18 -- potential biomarker of fibroinflammatory activity in chronic periaortitis. (PubMed id 22589264)¹ Kollert F....Warnatz K. (J. Rheumatol. 2012)
51. Pulmonary CCL18 recruits human regulatory T cells. (PubMed id 22649201)¹ Chenivesse C....Tsicopoulos A. (J. Immunol. 2012)
52. Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls. (PubMed id 22203932)¹ NariALa D....Anghel A. (Rom J Morphol Embryol 2011)
53. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. (PubMed id 21928244)¹ Wang Q....Li L. (Int. J. Biol. Markers 2011)
54. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. (PubMed id 21481794)¹ Chen J....Song E. (Cancer Cell 2011)
55. Serum CC chemokine ligand-18 predicts lung disease worsening in systemic sclerosis. (PubMed id 21778167)¹ Tiev K.P....Dinh-Xuan A.T. (Eur. Respir. J. 2011)
56. Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis. (PubMed id 21324976)¹ BellA^n T....Bajo M.A. (Nephrol. Dial. Transplant. 2011)
57. CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts. (PubMed id 21251883)¹ Mendez A....Rook G.A. (Tuberculosis (Edinb) 2011)
58. Exploring CCL18, eczema severity and atopy. (PubMed id 21539615)¹ Hon K.L....Leung T.F. (Pediatr Allergy Immunol 2011)
59. Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants. (PubMed id 20608885)¹ Kallankari H....Hallman M. (Ann. Med. 2010)
60. Cardiovascular determinants and prognostic significance of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary artery disease. (PubMed id 20674579)¹ De Sutter J....Van Damme J. (J. Mol. Cell. Cardiol. 2010)
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62. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (Genes Immun. 2010)
63. Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells. (PubMed id 20568229)¹ Catusse J....Burger M. (J. Cell. Physiol. 2010)
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65. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)¹ Rajaraman P....Chanock S.J. (amp 2009)
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106. The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion. (PubMed id 18188522)⁹ RAPdel F....Beuscher H.U. (Strahlenther Onkol 2008)
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111. Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. (PubMed id 16671879)⁹ Sakai A....Ito K. (J. Periodontol. 2006)
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115. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. (PubMed id 11358988)⁹ Vissers J.L....Adema G.J. (J. Leukoc. Biol. 2001)
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