Free for academic non-profit institutions. Other users need a Commercial license

CCL18 Gene(Protein Coding)

C-C Motif Chemokine Ligand 18

GCID:
GC17P036064
GIFtS:
45
Genes Participants
UDN Logo

Aliases for CCL18 Gene

Aliases for CCL18 Gene

  • C-C Motif Chemokine Ligand 18 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And Activation-Regulated 2 3
  • Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated) 2 3
  • Alternative Macrophage Activation-Associated CC Chemokine 1 3 4
  • Pulmonary And Activation-Regulated Chemokine 3 4
  • Macrophage Inflammatory Protein 4 3 4
  • Dendritic Cell Chemokine 1 3 4
  • CC Chemokine PARC 3 4
  • SCYA18 3 4
  • AMAC-1 3 4
  • DC-CK1 3 4
  • AMAC1 3 4
  • DCCK1 3 4
  • MIP-4 3 4
  • PARC 3 4
  • Pulmonary And Activation-Regulated 2
  • Chemokine (C-C Motif) Ligand 18 2
  • Small Inducible Cytokine A18 3
  • Small-Inducible Cytokine A18 4
  • Chemokine (C-C), Dendritic 3
  • C-C Motif Chemokine 18 3
  • CC Chemokine Ligand 18 3
  • CKb7 3
  • MIP4 4

External Ids for CCL18 Gene

Previous HGNC Symbols for CCL18 Gene

  • SCYA18

Previous GeneCards Identifiers for CCL18 Gene

  • GC17P034161
  • GC17P036427
  • GC17P034537
  • GC17P031415
  • GC17P034391
  • GC17P030576

Summaries for CCL18 Gene

Entrez Gene Summary for CCL18 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL18 Gene

CCL18 (C-C Motif Chemokine Ligand 18) is a Protein Coding gene. Diseases associated with CCL18 include Gaucher's Disease and Pulmonary Fibrosis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.

UniProtKB/Swiss-Prot for CCL18 Gene

  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

Additional gene information for CCL18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL18 Gene

Genomics for CCL18 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CCL18 Gene

Promoters and enhancers for CCL18 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I036064 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 550.8 +0.0 12 0.4 ZNF354B ATF2 CCL18 LOC105371746 ENSG00000277089
GH17I036102 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 11.2 +41.7 41733 6.2 PKNOX1 ATF1 SMAD1 KLF17 BMI1 SCRT2 ZNF143 ATF7 IKZF2 RUNX3 CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L MYO19 GGNBP2
GH17I036088 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.1 +25.6 25641 3.8 HDGF PKNOX1 SMAD1 RB1 NSD2 BMI1 YBX1 BATF KLF5 IRF4 CCL3 CCL18 CCL4 SLFN12L ENSG00000277089
GH17I035971 Enhancer 1.1 Ensembl ENCODE 10.9 -90.8 -90758 3.2 PKNOX1 FOXA2 MLX ZFP64 ZNF133 ARID4B ZNF48 ETS1 YY1 TCF12 GC17M036105 CCL18 GAS2L2 CCL14 ENSG00000273736
GH17I036092 Enhancer 0.9 FANTOM5 ENCODE 11.1 +28.1 28080 0.5 SRF BACH1 MAFG BATF ATF2 RELA IKZF1 ATF7 NFE2 ETV6 CCL3 CCL3L3 CCL4 CCL18 CCL5 GGNBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL18 gene promoter:

Genomic Locations for CCL18 Gene

Genomic Locations for CCL18 Gene
chr17:36,064,272-36,072,032
(GRCh38/hg38)
Size:
7,761 bases
Orientation:
Plus strand
chr17:34,391,640-34,399,392
(GRCh37/hg19)

Genomic View for CCL18 Gene

Genes around CCL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL18 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL18 Gene

Proteins for CCL18 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55774-CCL18_HUMAN
    Recommended name:
    C-C motif chemokine 18
    Protein Accession:
    P55774
    Secondary Accessions:
    • B5BUM2
    • Q53X71

    Protein attributes for CCL18 Gene

    Size:
    89 amino acids
    Molecular mass:
    9849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL18 Gene

neXtProt entry for CCL18 Gene

Protein Expression for CCL18 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCL18 Gene

Other Protein References for CCL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL18 Gene

Domains & Families for CCL18 Gene

Gene Families for CCL18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCL18 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55774

UniProtKB/Swiss-Prot:

CCL18_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL18: view

Function for CCL18 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CCL18 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
UniProtKB/Swiss-Prot Induction:
Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.

Phenotypes From GWAS Catalog for CCL18 Gene

Gene Ontology (GO) - Molecular Function for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21481794
GO:0008009 chemokine activity IBA,TAS --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL18: view
genes like me logo Genes that share phenotypes with CCL18: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL18 Gene

Localization for CCL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL18 gene
Compartment Confidence
extracellular 5
lysosome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL18 Gene

Pathways & Interactions for CCL18 Gene

genes like me logo Genes that share pathways with CCL18: view

Interacting Proteins for CCL18 Gene

Selected Interacting proteins: P55774-CCL18_HUMAN for CCL18 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9192897
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 9192897
GO:0007154 cell communication TAS 9192897
genes like me logo Genes that share ontologies with CCL18: view

No data available for SIGNOR curated interactions for CCL18 Gene

Drugs & Compounds for CCL18 Gene

Products:

  1. Drug

(6) Drugs for CCL18 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CCL18 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL18: view

Transcripts for CCL18 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCL18 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL18 Gene

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL18 Gene

No ASD Table

Relevant External Links for CCL18 Gene

GeneLoc Exon Structure for
CCL18
ECgene alternative splicing isoforms for
CCL18

Expression for CCL18 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL18 Gene

mRNA expression in normal human tissues for CCL18 Gene
mRNA expression by GTEx for CCL18 GenemRNA expression by BioGPS for CCL18 Gene

mRNA differential expression in normal tissues according to GTEx for CCL18 Gene

This gene is overexpressed in Lung (x25.8) and Artery - Aorta (x4.6).

Protein differential expression in normal tissues from HIPED for CCL18 Gene

This gene is overexpressed in Spinal cord (53.8) and Placenta (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL18 Gene



Protein tissue co-expression partners for CCL18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL18 Gene:

CCL18

SOURCE GeneReport for Unigene cluster for CCL18 Gene:

Hs.143961

mRNA Expression by UniProt/SwissProt for CCL18 Gene:

P55774-CCL18_HUMAN
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.

Evidence on tissue expression from TISSUES for CCL18 Gene

  • Lung(4.6)
  • Lymph node(4.6)
  • Spleen(4.5)
  • Blood(4.4)
genes like me logo Genes that share expression patterns with CCL18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL18 Gene

Orthologs for CCL18 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCL18 33
  • 99.25 (n)
Species where no ortholog for CCL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL18 Gene

ENSEMBL:
Gene Tree for CCL18 (if available)
TreeFam:
Gene Tree for CCL18 (if available)

Paralogs for CCL18 Gene

Paralogs for CCL18 Gene

(27) SIMAP similar genes for CCL18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL18: view

Variants for CCL18 Gene

Sequence variations from dbSNP and Humsavar for CCL18 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000201843 -- 36,063,621(+) G/A upstream_transcript_variant
rs1000304885 -- 36,063,049(+) A/G upstream_transcript_variant
rs1000358603 -- 36,063,372(+) C/G upstream_transcript_variant
rs1000930741 -- 36,062,339(+) G/T upstream_transcript_variant
rs1001058493 -- 36,068,151(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL18 Gene

Variant ID Type Subtype PubMed ID
dgv120e55 CNV gain 17911159
dgv3143n100 CNV gain 25217958
esv2762388 CNV gain+loss 21179565
nsv1059795 CNV gain 25217958
nsv574755 CNV gain 21841781
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL18 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL18 Gene

Disorders for CCL18 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCL18 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gaucher's disease
  • acid beta-glucosidase deficiency
pulmonary fibrosis
  • fibrosis of lung
dermatitis, atopic
  • atod
sarcoidosis 1
  • sarcoidosis, susceptibility to, 1
pulmonary fibrosis, idiopathic
  • ipf
- elite association - COSMIC cancer census association via MalaCards
Search CCL18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL18 Gene

Publications for CCL18 Gene

  1. Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes. (PMID: 10049593) Tasaki Y … Nomiyama H (Genomics 1999) 2 3 4 22 58
  2. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PMID: 9233607) Hieshima K … Nomiyama H (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 22 58
  3. Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis. (PMID: 11745396) Schutyser E … Van Damme J (European journal of immunology 2001) 3 4 22 58
  4. Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18. (PMID: 10087196) Guan P … McColl SR (Genomics 1999) 3 4 22 58
  5. Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. (PMID: 9570561) Kodelja V … Goerdt S (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 22 58

Products for CCL18 Gene

Sources for CCL18 Gene

Content
Loading form....