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CCL18 Gene(Protein Coding)

C-C Motif Chemokine Ligand 18

GCID:
GC17P036064
GIFtS:
54
Genes Participants
UDN Logo

Aliases for CCL18 Gene

Aliases for CCL18 Gene

  • C-C Motif Chemokine Ligand 18 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18, Pulmonary And Activation-Regulated 2 3
  • Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated) 2 3
  • Alternative Macrophage Activation-Associated CC Chemokine 1 3 4
  • Pulmonary And Activation-Regulated Chemokine 3 4
  • Macrophage Inflammatory Protein 4 3 4
  • Chemokine (C-C Motif) Ligand 18 2 5
  • Small-Inducible Cytokine A18 3 4
  • Dendritic Cell Chemokine 1 3 4
  • CC Chemokine PARC 3 4
  • SCYA18 3 4
  • AMAC-1 3 4
  • DC-CK1 3 4
  • AMAC1 3 4
  • DCCK1 3 4
  • MIP-4 3 4
  • PARC 3 4
  • Pulmonary And Activation-Regulated 2
  • Small Inducible Cytokine A18 3
  • Chemokine (C-C), Dendritic 3
  • CC Chemokine Ligand 18 3
  • CKb7 3
  • MIP4 4

External Ids for CCL18 Gene

Previous HGNC Symbols for CCL18 Gene

  • SCYA18

Previous GeneCards Identifiers for CCL18 Gene

  • GC17P034161
  • GC17P036427
  • GC17P034537
  • GC17P031415
  • GC17P034391
  • GC17P030576

Summaries for CCL18 Gene

Entrez Gene Summary for CCL18 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL18 Gene

CCL18 (C-C Motif Chemokine Ligand 18) is a Protein Coding gene. Diseases associated with CCL18 include Gaucher's Disease and Pulmonary Fibrosis. Among its related pathways are ERK Signaling and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot for CCL18 Gene

  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL18 Gene

Genomics for CCL18 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCL18 Gene

Enhancers for CCL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCL18 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CCL18 gene promoter:

Genomic Location for CCL18 Gene

Chromosome:
17
Start:
36,064,272 bp from pter
End:
36,072,032 bp from pter
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for CCL18 Gene

Genes around CCL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL18 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL18 Gene

Proteins for CCL18 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55774-CCL18_HUMAN
    Recommended name:
    C-C motif chemokine 18
    Protein Accession:
    P55774
    Secondary Accessions:
    • B5BUM2
    • Q53X71

    Protein attributes for CCL18 Gene

    Size:
    89 amino acids
    Molecular mass:
    9849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL18 Gene

neXtProt entry for CCL18 Gene

Proteomics data for CCL18 Gene at MOPED

Protein Expression for CCL18 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCL18 Gene

Other Protein References for CCL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL18 Gene

Domains & Families for CCL18 Gene

Gene Families for CCL18 Gene

HGNC:

Protein Domains for CCL18 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55774

UniProtKB/Swiss-Prot:

CCL18_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL18: view

Function for CCL18 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CCL18 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
UniProtKB/Swiss-Prot Induction:
Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.

Phenotypes for CCL18 Gene

GenomeRNAi human phenotypes for CCL18:
genes like me logo Genes that share phenotypes with CCL18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL18 Gene

Localization for CCL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL18 Gene COMPARTMENTS Subcellular localization image for CCL18 gene
Compartment Confidence
extracellular 5
lysosome 2
vacuole 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for CCL18 Gene

Pathways & Interactions for CCL18 Gene

genes like me logo Genes that share pathways with CCL18: view

Gene Ontology (GO) - Biological Process for CCL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9192897
GO:0006955 immune response IEA,TAS 9192897
GO:0007165 signal transduction TAS 9233607
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CCL18: view

No data available for SIGNOR curated interactions for CCL18 Gene

Drugs & Compounds for CCL18 Gene

Products:

  1. Drug

(6) Drugs for CCL18 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CCL18 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL18: view

Transcripts for CCL18 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCL18 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL18 Gene

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL18 Gene

No ASD Table

Relevant External Links for CCL18 Gene

GeneLoc Exon Structure for
CCL18
ECgene alternative splicing isoforms for
CCL18

Expression for CCL18 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CCL18 Gene

mRNA expression in normal human tissues for CCL18 Gene
mRNA expression by BioGPS for CCL18 GenemRNA expression by GTEx for CCL18 Gene

mRNA differential expression in normal tissues according to GTEx for CCL18 Gene

This gene is overexpressed in Lung (x25.8) and Artery - Aorta (x4.6).

Protein differential expression in normal tissues from HIPED for CCL18 Gene

This gene is overexpressed in Spinal cord (53.8) and Placenta (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL18 Gene



SOURCE GeneReport for Unigene cluster for CCL18 Gene Hs.143961

mRNA Expression by UniProt/SwissProt for CCL18 Gene

P55774-CCL18_HUMAN
Tissue specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.
genes like me logo Genes that share expression patterns with CCL18: view

Protein tissue co-expression partners for CCL18 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCL18 Gene

Orthologs for CCL18 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCL18 35
  • 99.25 (n)
  • 97.75 (a)
Species with no ortholog for CCL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL18 Gene

ENSEMBL:
Gene Tree for CCL18 (if available)
TreeFam:
Gene Tree for CCL18 (if available)

Paralogs for CCL18 Gene

Paralogs for CCL18 Gene

(27) SIMAP similar genes for CCL18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL18: view

Variants for CCL18 Gene

Sequence variations from dbSNP and Humsavar for CCL18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs14304 -- 36,071,135(-) GAGGT(A/G)GCCTC utr-variant-3-prime
rs712041 -- 36,065,173(+) AAATC(C/T)TATGA intron-variant
rs712042 -- 36,065,520(+) GACTG(A/G)TGCTG intron-variant
rs712043 -- 36,069,307(+) CTCCT(C/T)TCACT intron-variant
rs712044 -- 36,069,424(+) CACCA(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL18 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv120e55 CNV Gain 17911159
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850

Variation tolerance for CCL18 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCL18 Gene

Disorders for CCL18 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCL18 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gaucher's disease
  • lipoid histiocytosis
pulmonary fibrosis
  • fibrosis of lung
atopic dermatitis
  • eczema
interstitial lung disease
  • ild
sarcoidosis 1
  • sarcoidosis
- elite association - COSMIC cancer census association via MalaCards
Search CCL18 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL18

Genetic Association Database (GAD)
CCL18
Human Genome Epidemiology (HuGE) Navigator
CCL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL18
genes like me logo Genes that share disorders with CCL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL18 Gene

Publications for CCL18 Gene

  1. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. (PMID: 9233607) Hieshima K. … Nomiyama H. (J. Immunol. 1997) 2 3 4 23 67
  2. Chemokine PARC gene (SCYA18) generated by fusion of two MIP- 1alpha/LD78alpha-like genes. (PMID: 10049593) Tasaki Y. … Nomiyama H. (Genomics 1999) 2 3 23
  3. Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis. (PMID: 19808030) Boot R.G. … Aerts J.M. (Clin. Chim. Acta 2010) 3 23
  4. CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders. (PMID: 19958819) Chang C.Y. … Wu C.H. (Neuroscience 2010) 3 23
  5. Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum. (PMID: 19017877) Kim H.B. … Kita H. (Chest 2009) 3 23

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