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Aliases for CCL17 Gene

Aliases for CCL17 Gene

  • C-C Motif Chemokine Ligand 17 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17 2 3
  • Thymus And Activation-Regulated Chemokine 3 4
  • Chemokine (C-C Motif) Ligand 17 2 3
  • Small-Inducible Cytokine A17 3 4
  • CC Chemokine TARC 3 4
  • SCYA17 3 4
  • TARC 3 4
  • T Cell-Directed CC Chemokine 3
  • C-C Motif Chemokine 17 3
  • A-152E5.3 3
  • ABCD-2 3

External Ids for CCL17 Gene

Previous HGNC Symbols for CCL17 Gene

  • SCYA17

Previous GeneCards Identifiers for CCL17 Gene

  • GC16P047843
  • GC16P057498
  • GC16P057173
  • GC16P057214
  • GC16P055996
  • GC16P057438
  • GC16P043306

Summaries for CCL17 Gene

Entrez Gene Summary for CCL17 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL17 Gene

CCL17 (C-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include Eosinophilic Pneumonia and Paragonimiasis. Among its related pathways are PEDF Induced Signaling and Th2 Differentiation Pathway. GO annotations related to this gene include receptor binding and CCR4 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL17 Gene

  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Gene Wiki entry for CCL17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL17 Gene

Genomics for CCL17 Gene

Regulatory Elements for CCL17 Gene

Enhancers for CCL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G057633 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +240.6 240593 7.0 HDGF PKNOX1 CREB3L1 MLX ARID4B DMAP1 SLC30A9 ZNF766 FOS ZNF263 ADGRG1 ADGRG3 CCL17 PLLP CX3CL1 GC16P057639 GC16M057629
GH16G058125 1.8 FANTOM5 ENCODE dbSUPER 4.9 +731.8 731777 4.6 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 RSPRY1 CFAP20 POLR2C LOC101927556 CCL17 ENSG00000260545
GH16G057394 1 FANTOM5 ENCODE 5.9 -1.6 -1596 0.9 NFIB MAX CEBPG ZNF776 RCOR1 PRDM10 TRIM24 EZH2 CHD2 NFIA CX3CL1 CCL22 NUDT21 PLLP CNGB1 CCL17 ADGRG1 GC16M057389
GH16G057387 1.2 FANTOM5 ENCODE 3.5 -8.0 -7988 1.3 HDGF PKNOX1 ARID4B ZNF121 ZNF207 DEK ZNF263 MXD4 JUNB REST RSPRY1 LOC105371286 CCL22 LOC101927556 NUDT21 CIAPIN1 POLR2C CCL17 GC16M057308 CX3CL1
GH16G056631 0.7 ENCODE 4.4 -763.7 -763717 1.5 SCRT1 RNF2 SUZ12 HLF CBX2 YY1 JUND ZFHX2 MXD3 SCRT2 MT1L MT1E CCL17 MT1M MT1JP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL17 Gene

Chromosome:
16
Start:
57,396,190 bp from pter
End:
57,416,063 bp from pter
Size:
19,874 bases
Orientation:
Plus strand

Genomic View for CCL17 Gene

Genes around CCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL17 Gene

Proteins for CCL17 Gene

  • Protein details for CCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92583-CCL17_HUMAN
    Recommended name:
    C-C motif chemokine 17
    Protein Accession:
    Q92583
    Secondary Accessions:
    • A0N0Q9
    • Q2M287

    Protein attributes for CCL17 Gene

    Size:
    94 amino acids
    Molecular mass:
    10507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL17 Gene

neXtProt entry for CCL17 Gene

Post-translational modifications for CCL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL17 Gene

Antibody Products

  • Abcam antibodies for CCL17
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCL17

Protein Products

  • Abcam proteins for CCL17

Assay Products

  • Cloud-Clone Corp. Assay Kits for CCL17
  • Abcam assays for CCL17

No data available for DME Specific Peptides for CCL17 Gene

Domains & Families for CCL17 Gene

Gene Families for CCL17 Gene

Protein Domains for CCL17 Gene

Suggested Antigen Peptide Sequences for CCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92583

UniProtKB/Swiss-Prot:

CCL17_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL17: view

Function for CCL17 Gene

Molecular function for CCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene Ontology (GO) - Molecular Function for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8702936
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity TAS,IBA --
GO:0031729 CCR4 chemokine receptor binding IEA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL17: view
genes like me logo Genes that share phenotypes with CCL17: view

Animal Models for CCL17 Gene

MGI Knock Outs for CCL17:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL17

CRISPR Products

miRNA for CCL17 Gene

miRTarBase miRNAs that target CCL17

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL17 Gene

Localization for CCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL17 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IEA --
genes like me logo Genes that share ontologies with CCL17: view

Pathways & Interactions for CCL17 Gene

genes like me logo Genes that share pathways with CCL17: view

Gene Ontology (GO) - Biological Process for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9743322
GO:0006954 inflammatory response IEA,IBA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8702936
genes like me logo Genes that share ontologies with CCL17: view

No data available for SIGNOR curated interactions for CCL17 Gene

Drugs & Compounds for CCL17 Gene

(9) Drugs for CCL17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL17: view

Transcripts for CCL17 Gene

mRNA/cDNA for CCL17 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL17 Gene

Chemokine (C-C motif) ligand 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL17 Gene

No ASD Table

Relevant External Links for CCL17 Gene

GeneLoc Exon Structure for
CCL17
ECgene alternative splicing isoforms for
CCL17

Expression for CCL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL17 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.1), Lung (x6.1), and Esophagus - Mucosa (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL17 Gene:

CCL17

SOURCE GeneReport for Unigene cluster for CCL17 Gene:

Hs.546294

mRNA Expression by UniProt/SwissProt for CCL17 Gene:

Q92583-CCL17_HUMAN
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Evidence on tissue expression from TISSUES for CCL17 Gene

  • Blood(4.6)
  • Skin(2.8)
  • Lymph node(2.6)
  • Lung(2.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with CCL17: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL17 Gene

Orthologs for CCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL17 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia CCL17 34 35
  • 82.02 (n)
rat
(Rattus norvegicus)
Mammalia Ccl17 34
  • 75.93 (n)
mouse
(Mus musculus)
Mammalia Ccl17 34 16 35
  • 73.7 (n)
cow
(Bos Taurus)
Mammalia CCL17 34 35
  • 71.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCL17 35
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL17 35
  • 35 (a)
OneToOne
Species where no ortholog for CCL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL17 Gene

ENSEMBL:
Gene Tree for CCL17 (if available)
TreeFam:
Gene Tree for CCL17 (if available)

Paralogs for CCL17 Gene

(23) SIMAP similar genes for CCL17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CCL17 Gene

genes like me logo Genes that share paralogs with CCL17: view

No data available for Paralogs for CCL17 Gene

Variants for CCL17 Gene

Sequence variations from dbSNP and Humsavar for CCL17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000174590 -- 57,412,720(+) CCTGG(A/G)GCTGC intron-variant
rs1000277812 -- 57,400,065(+) TATAA(A/G)AAAAC intron-variant
rs1000508239 -- 57,409,955(+) ATGCT(C/T)AATCC intron-variant
rs1000614522 -- 57,404,466(+) GTAAC(A/C/T)GGAAG intron-variant, upstream-variant-2KB
rs1000668281 -- 57,404,694(+) GTAAG(A/G)CAGTT intron-variant, upstream-variant-2KB

Variation tolerance for CCL17 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL17 Gene

Human Gene Mutation Database (HGMD)
CCL17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL17 Gene

Disorders for CCL17 Gene

MalaCards: The human disease database

(31) MalaCards diseases for CCL17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
paragonimiasis
  • infection by paragonimus
alveolar echinococcosis
  • alveolococcosis
stevens-johnson syndrome/toxic epidermal necrolysis
  • drug-induced stevens johnson syndrome
dermatitis
  • eczema
- elite association - COSMIC cancer census association via MalaCards
Search CCL17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL17

Genetic Association Database (GAD)
CCL17
Human Genome Epidemiology (HuGE) Navigator
CCL17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL17
genes like me logo Genes that share disorders with CCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL17 Gene

Publications for CCL17 Gene

  1. The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PMID: 15500644) Tsunemi Y. … Tamaki K. (Exp. Dermatol. 2004) 3 22 46 64
  2. Structures of thymus and activation-regulated chemokine (TARC). (PMID: 12832759) Asojo O.A. … Lubkowski J. (Acta Crystallogr. D 2003) 3 4 22 64
  3. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi C.G. … Umland S.P. (Eur. J. Immunol. 1999) 3 4 22 64
  4. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PMID: 8702936) Imai T. … Yoshie O. (J. Biol. Chem. 1996) 2 3 4 64
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64

Products for CCL17 Gene

Sources for CCL17 Gene

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