Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCL17 Gene

protein-coding   GIFtS: 60
GCID: GC16P057438

Chemokine (C-C Motif) Ligand 17

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 17)
(Previous symbol: SCYA17)
  See CCL17-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chemokine (C-C Motif) Ligand 171 2     CC Chemokine TARC2 3
SCYA171 2 3 5     A-152E5.32
TARC2 3 5     ABCD-22
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 171 2     C-C Motif Chemokine 172
Small-Inducible Cytokine A172 3     T Cell-Directed CC Chemokine2
Thymus And Activation-Regulated Chemokine2 3     

External Ids:    HGNC: 106151   Entrez Gene: 63612   Ensembl: ENSG000001029707   OMIM: 6015205   UniProtKB: Q925833   

Export aliases for CCL17 gene to outside databases

Previous GC identifers: GC16P047843 GC16P057498 GC16P057173 GC16P057214 GC16P055996 GC16P043306


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCL17 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4
and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and
activation of mature T cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL17 Gene:
CCL17 (chemokine (C-C motif) ligand 17) is a protein-coding gene. Diseases associated with CCL17 include paragonimiasis, and mycosis fungoides. GO annotations related to this gene include chemokine activity and receptor binding.

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell
development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4

Gene Wiki entry for CCL17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL17 gene promoter:
         STAT5B   RelA   CUTL1   C/EBPalpha   PPAR-alpha   CREB   c-Rel   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL17 promoter sequence
   Search Chromatin IP Primers for CCL17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

CCL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL17 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057438:  view genomic region     (about GC identifiers)

Start:
57,438,679 bp from pter      End:
57,449,974 bp from pter
Size:
11,296 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583 (See protein sequence)
Recommended Name: C-C motif chemokine 17 precursor  
Size: 94 amino acids; 10507 Da
Caution: Was originally (PubMed:9521068) thought to be a ligand for CCR8
2 PDB 3D structures from and Proteopedia for CCL17:
1NR2 (3D)        1NR4 (3D)    
Secondary accessions: A0N0Q9 Q2M287

Explore the universe of human proteins at neXtProt for CCL17: NX_Q92583

Explore proteomics data for CCL17 at MOPED


See CCL17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002978.1  
ENSEMBL proteins: 
 ENSP00000219244  
Reactome Protein details: Q92583

CCL17 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL17 (CCL17/TARC)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CCL17
OriGene Custom MassSpec
OriGene Custom Protein Services for CCL17
GenScript Purified and Recombinant Proteins for CCL17
Novus Biologicals CCL17 Proteins
Novus Biologicals CCL17 Lysate
Sino Biological Recombinant Protein for CCL17
Sino Biological Cell Lysate for CCL17
ProSpec Recombinant Protein for CCL17
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CCL17 

 
antibodies-online proteins for CCL17 (45 products) 

 
antibodies-online peptides for CCL17

CCL17 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL17 (CCL17/TARC)
OriGene Antibodies for CCL17
OriGene Custom Antibody Services for CCL17
Novus Biologicals CCL17 Antibodies
Abcam antibodies for CCL17
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CCL17
antibodies-online antibodies for CCL17 (62 products) 

CCL17 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL17
R&D Systems Flow Cytometry Kits for CCL17 (CCL17/TARC)         (see first)
R&D Systems ELISAs for CCL17 (CCL17/TARC)
R&D Systems Luminex Assays for CCL17 (CCL17/TARC)
R&D Systems Proteome Profiler Antibody Arrays for CCL17 (CCL17/TARC)
See all other biochemical assays at R&D Systems
GenScript Custom Assay Services for CCL17
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CCL17 
antibodies-online kits for CCL17 (37 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
ENDOLIG: Endogenous ligands
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q92583

ProtoNet protein and cluster: Q92583

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
Similarity: Belongs to the intercrine beta (chemokine CC) family


Find genes that share domains with CCL17           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL17_HUMAN, Q92583
Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell
development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4
Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS8702936
GO:0008009chemokine activity IEA--
GO:0031729CCR4 chemokine receptor binding IEA--
     
Find genes that share ontologies with CCL17           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CCL17:
 Decreased G3BP1 protein expres 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccl17):
 cellular  hematopoietic system  immune system 

Find genes that share phenotypes with CCL17           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CCL17

miRNA
Products:
    
miRTarBase miRNAs that target CCL17:
hsa-mir-148b-3p (MIRT019326), hsa-mir-128-3p (MIRT021928)

Block miRNA regulation of human, mouse, rat CCL17 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCL17
SwitchGear 3'UTR luciferase reporter plasmidCCL17 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CCL17
Predesigned siRNA for gene silencing in human, mouse, rat CCL17

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL17

Clone
Products:
     
OriGene clones in human, mouse for CCL17 (see all 5)
OriGene ORF clones in mouse, rat for CCL17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL17 (NM_002987)
Sino Biological Human cDNA Clone for CCL17
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL17
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL17

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCL17
Browse ESI BIO Cell Lines and PureStem Progenitors for CCL17 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL17


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
CCL17_HUMAN, Q92583: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CCL17           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CCL17 About   (see all 11)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
4TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
5Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71


Find genes that share SuperPaths with CCL17           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCL17
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL17 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway

1 BioSystems Pathway for CCL17
    IL4-mediated signaling events


1 Reactome Pathway for CCL17
    Chemokine receptors bind chemokines


2 Kegg Pathways  (Kegg details for CCL17):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL17 (see all 7): 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CCL17

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCL17 (Q925833 ENSP000002192444) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
InteractantInteraction Details
GeneCardExternal ID(s)
CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
VCAM1P193203, ENSP000002947284I2D: score=4 STRING: ENSP00000294728
DARCQ165703, ENSP000003571034I2D: score=2 STRING: ENSP00000357103
CCL11ENSP000003022344STRING: ENSP00000302234
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis TAS9743322
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007186G-protein coupled receptor signaling pathway TAS8702936
GO:0007267cell-cell signaling TAS8702936

Find genes that share ontologies with CCL17           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCL17

Selected Novoseek inferred chemical compound relationships for CCL17 gene (see all 17)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 99.5 1017 15194145 (11), 14767451 (10), 12522366 (10), 12588369 (9) (see all 99)
larc 80.4 10 9365118 (3), 9153236 (1), 9169459 (1), 12239608 (1) (see all 7)
rantes 79.5 38 17460400 (2), 16802769 (2), 17165591 (2), 12832759 (2) (see all 30)
ccl3 68.5 6 12851650 (1), 16905241 (1), 17369706 (1), 17168792 (1) (see all 5)
[alcl] 50.3 7 11420464 (2), 12181269 (2)
olopatadine 49.5 6 15541638 (3), 15864020 (2)
ccl4 46.5 3 16905241 (1), 17369706 (1), 19421322 (1)
roxithromycin 39.9 5 19251402 (2), 14679761 (1)
il 10 30.1 3 15975968 (2), 11323220 (1)
allergens 28.2 4 17023689 (1), 17548604 (1), 15194145 (1), 17898016 (1)



Find genes that share compounds with CCL17           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CCL17 gene: 
NM_002987.2  

Unigene Cluster for CCL17:

Chemokine (C-C motif) ligand 17
Hs.546294
Unigene Representative Sequence: NM_002987
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000219244(uc002elj.1 uc010ccz.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CCL17 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCL17
SwitchGear 3'UTR luciferase reporter plasmidCCL17 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CCL17
Predesigned siRNA for gene silencing in human, mouse, rat CCL17
Clone
Products:
     
OriGene clones in human, mouse for CCL17 (see all 5)
OriGene ORF clones in mouse, rat for CCL17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL17 (NM_002987)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL17
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL17
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CCL17
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL17
  QuantiTect SYBR Green Assays in human, mouse, rat CCL17
  QuantiFast Probe-based Assays in human, mouse, rat CCL17

Additional mRNA sequence: 

BC069107.1 BC112066.1 BC112068.1 D43767.1 

1 DOTS entry:

DT.91916166 

4 AceView cDNA sequences:

BC069107 NM_002987 D43767 BE061171 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CCL17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCACAAAGG
CCL17 Expression
About this image


CCL17 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Ovary (Reproductive System)
         Oviduct
 
 Testis (Reproductive System)
         Seminiferous Tubules
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Brain (Nervous System)
         Cerebellum
CCL17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCL17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.546294

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL17 (see all 7): 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CCL17
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL17
QuantiTect SYBR Green Assays in human, mouse, rat CCL17
QuantiFast Probe-based Assays in human, mouse, rat CCL17
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for CCL17 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccl171 , 5 chemokine (C-C motif) ligand 171, 5 73.7(n)1
64.44(a)1
  8 (46.85 cM)5
202951  NM_011332.31  NP_035462.21 
 948104535 


ENSEMBL Gene Tree for CCL17 (if available)
TreeFam Gene Tree for CCL17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CCL17 gene
Selected SIMAP similar genes for CCL17 using alignment to 1 protein entry:     CCL17_HUMAN(see all similar genes):
CCL23    CCL15    CCL14    CCL26    CCL16    CCL8
CCL3    CCL11    CCL3L1    CCL3L3    CCL5    CCL22
CCL7    MCP-3    CCL18    CX3CL1    CCL2    CCL4L2

Find genes that share paralogs with CCL17           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CCL17
PGOHUM00000248925


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CCL17 (see all 316)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1907604871,2
--57436775(+) GTGCCA/GAGATA 1 -- us2k10--------
rs727929651,2
C,F--57436888(+) ACATAA/CGTAAG 1 -- us2k11Minor allele frequency- C:0.03NA 120
rs1829976851,2
--57437056(+) ATTATA/CTATAA 1 -- us2k10--------
rs1880692371,2
--57437099(+) TATAAC/TATATA 1 -- us2k10--------
rs116421961,2
H--57437208(+) atataA/Taatat 1 -- us2k10--------
rs116410951,2
H--57437209(+) tatatA/Tatata 1 -- us2k10--------
rs1925256481,2
--57437239(+) TATAAC/TATATA 1 -- us2k10--------
rs1855211801,2
--57437294(+) ACATAC/TATTAT 1 -- us2k10--------
rs1876492871,2
--57437301(+) TTATAG/TATAAT 1 -- us2k10--------
rs1926162881,2
--57437342(+) AATATA/GTATTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CCL17 (57438679 - 57449974 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CCL17: --
Human Gene Mutation Database (HGMD): CCL17
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCL17
DNA2.0 Custom Variant and Variant Library Synthesis for CCL17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 601520    OMIM disorders: --

Selected diseases for CCL17 (see all 23):    
About MalaCards
paragonimiasis    mycosis fungoides    stenotrophomonas maltophilia    lymphomatoid papulosis
allergic bronchopulmonary aspergillosis    atopic dermatitis    vernal keratoconjunctivitis    erythema multiforme
allergic contact dermatitis    pemphigus vulgaris    cutaneous t cell lymphoma    autoimmune thyroiditis
peripheral t-cell lymphoma    contact dermatitis    interstitial lung disease    pulmonary fibrosis
allergic rhinitis    eosinophilia    pneumonia    atopy

6 diseases from the University of Copenhagen DISEASES database for CCL17:
Atopic dermatitis     Asthma     Eosinophilia     Hypersensitivity reaction type I disease
Allergic rhinitis     Contact dermatitis

Find genes that share disorders with CCL17           About GenesLikeMe

Selected Novoseek inferred disease relationships for CCL17 gene (see all 40)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dermatitis atopic 80.3 34 10998136 (4), 12715916 (2), 15194145 (2), 11323220 (2) (see all 21)
skin diseases 56 6 16859899 (3)
pneumonia eosinophilic 53.6 8 11956056 (3), 15751278 (1), 12757454 (1)
asthma 51.5 20 16387595 (2), 16543550 (2), 12645858 (2), 11929424 (2) (see all 13)
inflammation 49.6 25 17023689 (3), 15993846 (2), 17848804 (1), 11737030 (1) (see all 19)
eczema 45 3 16499646 (2), 12269940 (1)
fibrosis idiopathic pulmonary 43.4 4 11956056 (1), 15383605 (1), 19715610 (1)
hodgkin disease 42.3 11 15994922 (4), 19591376 (1), 11420464 (1), 18541724 (1) (see all 5)
bronchoalveolar lavage fluid 42 7 12757454 (2), 12750406 (1), 16387607 (1), 11306430 (1) (see all 5)
allergic rhinitis 41.8 7 16261952 (3), 11737045 (2), 12445798 (1), 17982926 (1)

Genetic Association Database (GAD): CCL17
Human Genome Epidemiology (HuGE) Navigator: CCL17 (8 documents)

Export disorders for CCL17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CCL17 gene, integrated from 10 sources (see all 314):
(articles sorted by number of sources associating them with CCL17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PubMed id 8702936)1, 2, 3 Imai T.... Yoshie O. (J. Biol. Chem. 1996)
  2. Structures of thymus and activation-regulated chemokine (TARC). (PubMed id 12832759)1, 2, 9 Asojo O.A.... Lubkowski J. (Acta Crystallogr. D 2003)
  3. The -431C&gt;T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PubMed id 15500644)1, 4, 9 Tsunemi Y....Tamaki K. (Exp. Dermatol. 2004)
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)1, 2, 9 Garlisi C.G....Umland S.P. (Eur. J. Immunol. 1999)
  5. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PubMed id 18691306)1, 4, 9 Chan I.H....Lam C.W. (Allergy 2008)
  6. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)1, 2, 9 Bernardini G....Napolitano M. (Eur. J. Immunol. 1998)
  7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  9. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis. (PubMed id 17967467)1, 4 Galimberti D....Scarpini E. (J. Neurol. Sci. 2008)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 6361 HGNC: 10615 AceView: CCL17 Ensembl:ENSG00000102970 euGenes: HUgn6361
ECgene: CCL17 Kegg: 6361 H-InvDB: CCL17

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for CCL17 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL17

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for CCL17 gene:
Search GeneIP for patents involving CCL17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for CCL17 (CCL17/TARC)   Browse Cell Culture Products  
 ELISAs for CCL17 (CCL17/TARC)   Flow Cytometry Kits for CCL17 (CCL17/TARC)  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for CCL17 (CCL17/TARC)  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for CCL17 (CCL17/TARC)   Browse Stem Cell Products  
 Browse cDNA Clones   Proteome Profiler Antibody Arrays for CCL17 (CCL17/TARC)  
 OriGene Antibodies for CCL17   OriGene RNAi products in human, mouse, rat for CCL17  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CCL17  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CCL17  
 OriGene qSTAR qPCR primer pairs in human, mouse for CCL17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CCL17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CCL17   OriGene Custom Protein Services for CCL17  

 
 
 Block miRNA regulation of human, mouse, rat CCL17 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCL17
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL17 Predesigned siRNA for gene silencing in human, mouse, rat CCL17
 QuantiFast Probe-based Assays in human, mouse, rat CCL17 QuantiTect SYBR Green Assays in human, mouse, rat CCL17
 PCR Arrays including human, mouse, rat CCL17 Search Chromatin IP Primers for CCL17
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL17  GeneGlobe Interaction Network for CCL17
 Regulatory tfbs in CCL17 promoter
 GenScript Purified and Recombinant Proteins for CCL17 GenScript cDNA clones with any tag delivered in your preferred vector for CCL17
 GenScript Custom Assay Services for CCL17 GenScript Custom overexpressing Cell Line Services for CCL17
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for CCL17
 Proteins for CCL17
 Cell Lysates for CCL17
 cDNA Clones for CCL17
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CCL17 antibodies
 CCL17 proteins
 CCL17 lysates
 Antibodies for CCL17
 See all of Abcam's Antibodies, Kits and Proteins for CCL17
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for CCL17
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for CCL17
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL17
 SwitchGear 3'UTR luciferase reporter plasmids for CCL17
 SwitchGear Promoter luciferase reporter plasmids for CCL17
 ThermoFisher Antibodies for CCL17
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL17
 Browse compounds at ApexBio
 Search Addgene for plasmids for CCL17
  Search eBioscience for proteins for CCL17
  Search eBioscience for elisas for CCL17
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for CCL17
 antibodies-online antibodies for CCL17 (62 products)
 antibodies-online kits for CCL17 (37 products)
 antibodies-online peptides for CCL17
 antibodies-online proteins for CCL17 (45 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CCL17 gene at Home site.
Version: 3.12.250 16 Nov 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4