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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL17 Gene

protein-coding   GIFtS: 61
GCID: GC16P057438

Chemokine (C-C Motif) Ligand 17

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 17)
(Previous symbol: SCYA17)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 171 2     CC Chemokine TARC2 3
SCYA171 2 3 5     A-152E5.32
TARC2 3 5     ABCD-22
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 171 2     C-C Motif Chemokine 172
Small-Inducible Cytokine A172 3     T Cell-Directed CC Chemokine2
Thymus And Activation-Regulated Chemokine2 3     

External Ids:    HGNC: 106151   Entrez Gene: 63612   Ensembl: ENSG000001029707   OMIM: 6015205   UniProtKB: Q925833   

Export aliases for CCL17 gene to outside databases

Previous GC identifers: GC16P047843 GC16P057498 GC16P057173 GC16P057214 GC16P055996 GC16P043306


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL17 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4
and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and
activation of mature T cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL17 Gene: 
CCL17 (chemokine (C-C motif) ligand 17) is a protein-coding gene. Diseases associated with CCL17 include allergic bronchopulmonary aspergillosis, and paragonimiasis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity and receptor binding.

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell
development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4

Gene Wiki entry for CCL17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL17 gene promoter:
         STAT5B   RelA   CUTL1   C/EBPalpha   PPAR-alpha   CREB   c-Rel   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL17 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

CCL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL17 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057438:  view genomic region     (about GC identifiers)

Start:
57,438,679 bp from pter      End:
57,449,974 bp from pter
Size:
11,296 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583 (See protein sequence)
Recommended Name: C-C motif chemokine 17 precursor  
Size: 94 amino acids; 10507 Da
Subcellular location: Secreted
Caution: Was originally (PubMed:9521068) thought to be a ligand for CCR8
2 PDB 3D structures from and Proteopedia for CCL17:
1NR2 (3D)        1NR4 (3D)    
Secondary accessions: A0N0Q9 Q2M287

Explore the universe of human proteins at neXtProt for CCL17: NX_Q92583

Explore proteomics data for CCL17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92583

  • CCL17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL17 Protein Expression
    REFSEQ proteins: NP_002978.1  
    ENSEMBL proteins: 
     ENSP00000219244  
    Reactome Protein details: Q92583
    Human Recombinant Protein Products for CCL17: 
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    OriGene Protein Over-expression Lysate for CCL17
    OriGene Custom MassSpec 
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    GenScript Purified and Recombinant Proteins for CCL17
    Novus Biologicals CCL17 Proteins
    Novus Biologicals CCL17 Lysate
    Sino Biological Recombinant Protein for CCL17
    Sino Biological Cell Lysate for CCL17 
    ProSpec Recombinant Protein for CCL17
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL17 for ontologies           About GeneDecksing



    CCL17 Antibody Products: 
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    Novus Biologicals CCL17 Antibodies
    Abcam antibodies for CCL17
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    ThermoFisher Antibodies for CCL17
    LSBio Antibodies in human, mouse, rat for CCL17 

    Assay Products for CCL17: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for CCL17 (CCL17/TARC)         (see all)
    GenScript Custom Assay Services for CCL17
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q92583

    ProtoNet protein and cluster: Q92583

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL17_HUMAN, Q92583
    Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell
    development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4
    Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8702936
    GO:0008009chemokine activity IEA--
         
    CCL17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL17:
     Decreased G3BP1 protein expres 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccl17):
     immune system 

    CCL17 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL17 

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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CCL17

    Clone
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    GenScript: all cDNA clones in your preferred vector: CCL17 (NM_002987)
    Sino Biological Human cDNA Clone for CCL17
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL17
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                         Customized lentivirus expression plasmids for stable overexpression of CCL17 

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    Search LifeMap BioReagents cell lines for CCL17
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL17 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL17 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 BioSystems Pathway for CCL17
        IL4-mediated signaling events


    5/6        Reactome Pathways for CCL17 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for CCL17):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for CCL17 (Q925833 ENSP000002192444) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR4P516793, ENSP000003326594I2D: score=2 STRING: ENSP00000332659
    CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
    VCAM1P193203, ENSP000002947284I2D: score=4 STRING: ENSP00000294728
    DARCQ165703, ENSP000003571034I2D: score=2 STRING: ENSP00000357103
    CCL11ENSP000003022344STRING: ENSP00000302234
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS8702936
    GO:0007267cell-cell signaling TAS8702936

    CCL17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL17

    10/17 Novoseek inferred chemical compound relationships for CCL17 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 99.5 1017 15194145 (11), 14767451 (10), 12522366 (10), 12588369 (9) (see all 99)
    larc 80.4 10 9365118 (3), 9153236 (1), 9169459 (1), 12239608 (1) (see all 7)
    rantes 79.5 38 17460400 (2), 16802769 (2), 17165591 (2), 12832759 (2) (see all 30)
    ccl3 68.5 6 12851650 (1), 16905241 (1), 17369706 (1), 17168792 (1) (see all 5)
    [alcl] 50.3 7 11420464 (2), 12181269 (2)
    olopatadine 49.5 6 15541638 (3), 15864020 (2)
    ccl4 46.5 3 16905241 (1), 17369706 (1), 19421322 (1)
    roxithromycin 39.9 5 19251402 (2), 14679761 (1)
    il 10 30.1 3 15975968 (2), 11323220 (1)
    allergens 28.2 4 17023689 (1), 17548604 (1), 15194145 (1), 17898016 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL17 gene: 
    NM_002987.2  

    Unigene Cluster for CCL17:

    Chemokine (C-C motif) ligand 17
    Hs.546294
    Unigene Representative Sequence: NM_002987
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000219244(uc002elj.1 uc010ccz.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL17
    SwitchGear 3'UTR luciferase reporter plasmidCCL17 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL17

    Additional mRNA sequence: 

    BC069107.1 BC112066.1 BC112068.1 D43767.1 

    1 DOTS entry:

    DT.91916166 

    4 AceView cDNA sequences:

    D43767 BC069107 NM_002987 BE061171 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL17 expression in normal human tissues (normalized intensities)      CCL17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACAAAGG
    CCL17 Expression
    About this image


    CCL17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             Seminiferous Tubules
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocyte-derived dendritic cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   

    See CCL17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL17

    SOURCE GeneReport for Unigene cluster: Hs.546294

    UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583
    Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL17 (see all 7): 
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL17 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl171 , 5 chemokine (C-C motif) ligand 171, 5 73.7(n)1
    64.44(a)1
      8 (46.85 cM)5
    202951  NM_011332.31  NP_035462.21 
     948104535 
    chicken
    (Gallus gallus)
    Aves CCL176
    Uncharacterized protein
    44(a)
    1 ↔ 1
    11(777104-778328)


    ENSEMBL Gene Tree for CCL17 (if available)
    TreeFam Gene Tree for CCL17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL17 gene
    18/23 SIMAP similar genes for CCL17 using alignment to 1 protein entry:     CCL17_HUMAN(see all similar genes):
    CCL23    CCL15    CCL14    CCL26    CCL16    CCL8
    CCL3    CCL11    CCL3L1    CCL3L3    CCL5    CCL22
    CCL7    MCP-3    CCL18    CX3CL1    CCL2    CCL4L2

    CCL17 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCL17
    PGOHUM00000248925


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/316 SNPs in CCL17 are shown (see all 316)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907604871,2
    --57436775(+) GTGCCA/GAGATA 1 -- us2k10--------
    rs727929651,2
    C,F--57436888(+) ACATAA/CGTAAG 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1829976851,2
    --57437056(+) ATTATA/CTATAA 1 -- us2k10--------
    rs1880692371,2
    --57437099(+) TATAAC/TATATA 1 -- us2k10--------
    rs116421961,2
    H--57437208(+) atataA/Taatat 1 -- us2k10--------
    rs116410951,2
    H--57437209(+) tatatA/Tatata 1 -- us2k10--------
    rs1925256481,2
    --57437239(+) TATAAC/TATATA 1 -- us2k10--------
    rs1855211801,2
    --57437294(+) ACATAC/TATTAT 1 -- us2k10--------
    rs1876492871,2
    --57437301(+) TTATAG/TATAAT 1 -- us2k10--------
    rs1926162881,2
    --57437342(+) AATATA/GTATTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL17 (57438679 - 57449974 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCL17: --

    Human Gene Mutation Database (HGMD): CCL17
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL17
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601520    OMIM disorders: --

    20/74 diseases for CCL17 (see all 74):    About MalaCards
    allergic bronchopulmonary aspergillosis    paragonimiasis    lymphomatoid papulosis    mycosis fungoides
    cutaneous lupus erythematosus    atopic dermatitis    erythema multiforme    peripheral t-cell lymphoma
    vernal keratoconjunctivitis    eosinophilic pneumonia    anaplastic large cell lymphoma    pulmonary fibrosis
    toxic epidermal necrolysis    stevens-johnson syndrome    contact dermatitis    allergic contact dermatitis
    aspergillosis    allergic rhinitis    eczema    pulmonary eosinophilia

    6 diseases from the University of Copenhagen DISEASES database for CCL17:
    Atopic dermatitis     Asthma     Eosinophilia     Hypersensitivity reaction type I disease
    Allergic rhinitis     Contact dermatitis

    CCL17 for disorders           About GeneDecksing

    10/40 Novoseek inferred disease relationships for CCL17 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 80.3 34 10998136 (4), 12715916 (2), 15194145 (2), 11323220 (2) (see all 21)
    skin diseases 56 6 16859899 (3)
    pneumonia eosinophilic 53.6 8 11956056 (3), 15751278 (1), 12757454 (1)
    asthma 51.5 20 16387595 (2), 16543550 (2), 12645858 (2), 11929424 (2) (see all 13)
    inflammation 49.6 25 17023689 (3), 15993846 (2), 17848804 (1), 11737030 (1) (see all 19)
    eczema 45 3 16499646 (2), 12269940 (1)
    fibrosis idiopathic pulmonary 43.4 4 11956056 (1), 15383605 (1), 19715610 (1)
    hodgkin disease 42.3 11 15994922 (4), 19591376 (1), 11420464 (1), 18541724 (1) (see all 5)
    bronchoalveolar lavage fluid 42 7 12757454 (2), 12750406 (1), 16387607 (1), 11306430 (1) (see all 5)
    allergic rhinitis 41.8 7 16261952 (3), 11737045 (2), 12445798 (1), 17982926 (1)

    Genetic Association Database (GAD): CCL17
    Human Genome Epidemiology (HuGE) Navigator: CCL17 (8 documents)

    Export disorders for CCL17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL17 gene, integrated from 9 sources (see all 310):
    (articles sorted by number of sources associating them with CCL17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PubMed id 8702936)1, 2, 3 Imai T.... Yoshie O. (1996)
    2. Structures of thymus and activation-regulated chemokine (TARC). (PubMed id 12832759)1, 2, 9 Asojo O.A.... Lubkowski J. (2003)
    3. The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PubMed id 15500644)1, 4, 9 Tsunemi Y....Tamaki K. (2004)
    4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)1, 2, 9 Garlisi C.G....Umland S.P. (1999)
    5. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PubMed id 18691306)1, 4, 9 Chan I.H....Lam C.W. (2008)
    6. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)1, 2, 9 Bernardini G....Napolitano M. (1998)
    7. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    9. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis. (PubMed id 17967467)1, 4 Galimberti D....Scarpini E. (2008)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6361 HGNC: 10615 AceView: CCL17 Ensembl:ENSG00000102970 euGenes: HUgn6361
    ECgene: CCL17 Kegg: 6361 H-InvDB: CCL17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL17 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL17

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL17 gene:
    Search GeneIP for patents involving CCL17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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