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Aliases for CCL17 Gene

Aliases for CCL17 Gene

  • C-C Motif Chemokine Ligand 17 2 3
  • Chemokine (C-C Motif) Ligand 17 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17 2 3
  • Thymus And Activation-Regulated Chemokine 3 4
  • Small-Inducible Cytokine A17 3 4
  • CC Chemokine TARC 3 4
  • SCYA17 3 4
  • TARC 3 4
  • T Cell-Directed CC Chemokine 3
  • A-152E5.3 3
  • ABCD-2 3

External Ids for CCL17 Gene

Previous HGNC Symbols for CCL17 Gene

  • SCYA17

Previous GeneCards Identifiers for CCL17 Gene

  • GC16P047843
  • GC16P057498
  • GC16P057173
  • GC16P057214
  • GC16P055996
  • GC16P057438
  • GC16P043306

Summaries for CCL17 Gene

Entrez Gene Summary for CCL17 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL17 Gene

CCL17 (C-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include eosinophilic pneumonia and churg-strauss syndrome. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include receptor binding and CCR4 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL17 Gene

  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Gene Wiki entry for CCL17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL17 Gene

Genomics for CCL17 Gene

Regulatory Elements for CCL17 Gene

Genomic Location for CCL17 Gene

Chromosome:
16
Start:
57,396,190 bp from pter
End:
57,416,063 bp from pter
Size:
19,874 bases
Orientation:
Plus strand

Genomic View for CCL17 Gene

Genes around CCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL17 Gene

Proteins for CCL17 Gene

  • Protein details for CCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92583-CCL17_HUMAN
    Recommended name:
    C-C motif chemokine 17
    Protein Accession:
    Q92583
    Secondary Accessions:
    • A0N0Q9
    • Q2M287

    Protein attributes for CCL17 Gene

    Size:
    94 amino acids
    Molecular mass:
    10507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL17 Gene

neXtProt entry for CCL17 Gene

Proteomics data for CCL17 Gene at MOPED

Post-translational modifications for CCL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL17 Gene

Domains & Families for CCL17 Gene

Gene Families for CCL17 Gene

Protein Domains for CCL17 Gene

Suggested Antigen Peptide Sequences for CCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92583

UniProtKB/Swiss-Prot:

CCL17_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL17: view

Function for CCL17 Gene

Molecular function for CCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene Ontology (GO) - Molecular Function for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL17: view
genes like me logo Genes that share phenotypes with CCL17: view

Animal Models for CCL17 Gene

MGI Knock Outs for CCL17:

Animal Model Products

CRISPR Products

miRNA for CCL17 Gene

miRTarBase miRNAs that target CCL17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL17 Gene

Localization for CCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL17 Gene COMPARTMENTS Subcellular localization image for CCL17 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CCL17 Gene

Pathways & Interactions for CCL17 Gene

genes like me logo Genes that share pathways with CCL17: view

Gene Ontology (GO) - Biological Process for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9743322
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8702936
GO:0007275 multicellular organism development TAS 8702936
genes like me logo Genes that share ontologies with CCL17: view

No data available for SIGNOR curated interactions for CCL17 Gene

Drugs & Compounds for CCL17 Gene

(9) Drugs for CCL17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL17: view

Transcripts for CCL17 Gene

mRNA/cDNA for CCL17 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL17 Gene

Chemokine (C-C motif) ligand 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL17 Gene

No ASD Table

Relevant External Links for CCL17 Gene

GeneLoc Exon Structure for
CCL17
ECgene alternative splicing isoforms for
CCL17

Expression for CCL17 Gene

mRNA expression in normal human tissues for CCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL17 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.1), Lung (x6.1), and Esophagus - Mucosa (x4.1).

SOURCE GeneReport for Unigene cluster for CCL17 Gene Hs.546294

mRNA Expression by UniProt/SwissProt for CCL17 Gene

Q92583-CCL17_HUMAN
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
genes like me logo Genes that share expression patterns with CCL17: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL17 Gene

Orthologs for CCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL17 35
  • 99.65 (n)
  • 100 (a)
CCL17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL17 36
  • 55 (a)
OneToOne
CCL17 35
  • 71.99 (n)
  • 59.57 (a)
dog
(Canis familiaris)
Mammalia CCL17 35
  • 82.02 (n)
  • 77.53 (a)
CCL17 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl17 36
  • 56 (a)
OneToOne
Ccl17 16
Ccl17 35
  • 73.7 (n)
  • 64.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CCL17 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCL17 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl17 35
  • 75.93 (n)
  • 65.56 (a)
Species with no ortholog for CCL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL17 Gene

ENSEMBL:
Gene Tree for CCL17 (if available)
TreeFam:
Gene Tree for CCL17 (if available)

Paralogs for CCL17 Gene

(23) SIMAP similar genes for CCL17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CCL17 Gene

genes like me logo Genes that share paralogs with CCL17: view

No data available for Paralogs for CCL17 Gene

Variants for CCL17 Gene

Sequence variations from dbSNP and Humsavar for CCL17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34693308 - 57,413,947(+) CTGAA(G/T)ATGCT reference, missense
rs34379253 - 57,415,775(+) TAACT(A/G)TGCAG reference, missense
rs170367 -- 57,404,435(+) GTCAG(A/G)GATAG intron-variant, upstream-variant-2KB
rs170368 -- 57,411,481(+) GAAAG(C/T)GAAGA intron-variant
rs686014 -- 57,400,815(+) actac(A/C)aaaat intron-variant

Variation tolerance for CCL17 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL17 Gene

HapMap Linkage Disequilibrium report
CCL17
Human Gene Mutation Database (HGMD)
CCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL17 Gene

Disorders for CCL17 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CCL17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
churg-strauss syndrome
  • allergic granulomatosis angiitis
paragonimiasis
  • infection by paragonimus
allergic bronchopulmonary aspergillosis
  • pulmonary aspergillus disease
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search CCL17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL17

Genetic Association Database (GAD)
CCL17
Human Genome Epidemiology (HuGE) Navigator
CCL17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL17
genes like me logo Genes that share disorders with CCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL17 Gene

Publications for CCL17 Gene

  1. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PMID: 8702936) Imai T. … Yoshie O. (J. Biol. Chem. 1996) 2 3 4 67
  2. The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes. (PMID: 19371952) Qi X.F. … Lee K.J. (Mol. Immunol. 2009) 3 23
  3. Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. (PMID: 17898016) Latzin P. … Casaulta C. (Eur. Respir. J. 2008) 3 23
  4. Induction of TARC production by lipopolysaccharide and interleukin-4 in nasal fibroblasts. (PMID: 18004070) Fukumoto A. … Pawankar R. (Int. Arch. Allergy Immunol. 2008) 3 23
  5. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. (PMID: 18266834) Nakazato J. … Shinomiya N. (Pediatr Allergy Immunol 2008) 3 23

Products for CCL17 Gene

Sources for CCL17 Gene

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