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Aliases for CCL17 Gene

Aliases for CCL17 Gene

  • Chemokine (C-C Motif) Ligand 17 2 3
  • SCYA17 3 4 6
  • TARC 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17 2 3
  • Thymus And Activation-Regulated Chemokine 3 4
  • Small-Inducible Cytokine A17 3 4
  • CC Chemokine TARC 3 4
  • T Cell-Directed CC Chemokine 3
  • C-C Motif Chemokine 17 3
  • A-152E5.3 3
  • ABCD-2 3

External Ids for CCL17 Gene

Previous HGNC Symbols for CCL17 Gene

  • SCYA17

Previous GeneCards Identifiers for CCL17 Gene

  • GC16P047843
  • GC16P057498
  • GC16P057173
  • GC16P057214
  • GC16P055996
  • GC16P057438
  • GC16P043306

Summaries for CCL17 Gene

Entrez Gene Summary for CCL17 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL17 Gene

CCL17 (Chemokine (C-C Motif) Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include mycosis fungoides and paragonimiasis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and chemokine activity.

UniProtKB/Swiss-Prot for CCL17 Gene

  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Gene Wiki entry for CCL17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL17 Gene

Genomics for CCL17 Gene

Regulatory Elements for CCL17 Gene

Genomic Location for CCL17 Gene

Start:
57,404,767 bp from pter
End:
57,416,062 bp from pter
Size:
11,296 bases
Orientation:
Plus strand

Genomic View for CCL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL17 Gene

Proteins for CCL17 Gene

  • Protein details for CCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92583-CCL17_HUMAN
    Recommended name:
    C-C motif chemokine 17
    Protein Accession:
    Q92583
    Secondary Accessions:
    • A0N0Q9
    • Q2M287

    Protein attributes for CCL17 Gene

    Size:
    94 amino acids
    Molecular mass:
    10507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL17 Gene

neXtProt entry for CCL17 Gene

Proteomics data for CCL17 Gene at MOPED

Post-translational modifications for CCL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL17 Gene

Domains for CCL17 Gene

Gene Families for CCL17 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL17 Gene

Suggested Antigen Peptide Sequences for CCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92583

UniProtKB/Swiss-Prot:

CCL17_HUMAN :
  • Q92583
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL17: view

Function for CCL17 Gene

Molecular function for CCL17 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
UniProtKB/Swiss-Prot Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes

Gene Ontology (GO) - Molecular Function for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8702936
GO:0008009 chemokine activity IEA --
GO:0031729 CCR4 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with CCL17: view
genes like me logo Genes that share phenotypes with CCL17: view

miRNA for CCL17 Gene

miRTarBase miRNAs that target CCL17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL17 Gene

Localization for CCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL17 Gene COMPARTMENTS Subcellular localization image for CCL17 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL17: view

Pathways for CCL17 Gene

genes like me logo Genes that share pathways with CCL17: view

Gene Ontology (GO) - Biological Process for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 9743322
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8702936
GO:0007267 cell-cell signaling TAS 8702936
genes like me logo Genes that share ontologies with CCL17: view

Compounds for CCL17 Gene

(17) Novoseek inferred chemical compound relationships for CCL17 Gene

Compound -log(P) Hits PubMed IDs
tarc 99.5 603
larc 80.4 9
rantes 79.5 36
ccl3 68.5 5
[alcl] 50.3 4
genes like me logo Genes that share compounds with CCL17: view

Transcripts for CCL17 Gene

mRNA/cDNA for CCL17 Gene

(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL17 Gene

Chemokine (C-C motif) ligand 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL17 Gene

No ASD Table

Relevant External Links for CCL17 Gene

GeneLoc Exon Structure for
CCL17
ECgene alternative splicing isoforms for
CCL17

Expression for CCL17 Gene

mRNA expression in normal human tissues for CCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL17 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (7.1), Lung (6.1), and Esophagus - Mucosa (4.1).

SOURCE GeneReport for Unigene cluster for CCL17 Gene Hs.546294

mRNA Expression by UniProt/SwissProt for CCL17 Gene

Q92583-CCL17_HUMAN
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine
genes like me logo Genes that share expressions with CCL17: view

No data available for Protein expression for CCL17 Gene

Orthologs for CCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL17 35
  • 99.65 (n)
  • 100 (a)
CCL17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL17 35
  • 71.99 (n)
  • 59.57 (a)
CCL17 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL17 35
  • 82.02 (n)
  • 77.53 (a)
CCL17 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl17 35
  • 73.7 (n)
  • 64.44 (a)
Ccl17 16
Ccl17 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL17 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCL17 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl17 35
  • 75.93 (n)
  • 65.56 (a)
Species with no ortholog for CCL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL17 Gene

ENSEMBL:
Gene Tree for CCL17 (if available)
TreeFam:
Gene Tree for CCL17 (if available)

Paralogs for CCL17 Gene

Selected SIMAP similar genes for CCL17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CCL17 Gene

genes like me logo Genes that share paralogs with CCL17: view

No data available for Paralogs for CCL17 Gene

Variants for CCL17 Gene

Sequence variations from dbSNP and Humsavar for CCL17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs170367 -- 57,404,435(+) GTCAG(A/G)GATAG upstream-variant-2KB
rs170368 -- 57,411,481(+) GAAAG(C/T)GAAGA intron-variant
rs184402 -- 57,411,342(+) CCAGC(C/T)AGGCA intron-variant
rs223827 -- 57,412,095(+) AGGCC(C/T)ACCAA intron-variant
rs223828 -- 57,413,502(+) CTGGT(C/T)GACTC intron-variant

Relevant External Links for CCL17 Gene

HapMap Linkage Disequilibrium report
CCL17
Human Gene Mutation Database (HGMD)
CCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL17 Gene

Disorders for CCL17 Gene

(40) Novoseek inferred disease relationships for CCL17 Gene

Disease -log(P) Hits PubMed IDs
dermatitis atopic 80.3 30
skin diseases 56 3
pneumonia eosinophilic 53.6 5
asthma 51.5 18
inflammation 49.6 22

Relevant External Links for CCL17

Genetic Association Database (GAD)
CCL17
Human Genome Epidemiology (HuGE) Navigator
CCL17
genes like me logo Genes that share disorders with CCL17: view

No data available for UniProtKB/Swiss-Prot for CCL17 Gene

Publications for CCL17 Gene

  1. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi C.G. … Umland S.P. (Eur. J. Immunol. 1999) 3 4 23
  2. Structures of thymus and activation-regulated chemokine (TARC). (PMID: 12832759) Asojo O.A. … Lubkowski J. (Acta Crystallogr. D 2003) 3 4 23
  3. The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PMID: 15500644) Tsunemi Y. … Tamaki K. (Exp. Dermatol. 2004) 3 23 48
  4. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PMID: 8702936) Imai T. … Yoshie O. (J. Biol. Chem. 1996) 2 3 4
  5. Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13. (PMID: 9070951) Nomiyama H. … Yoshie O. (Genomics 1997) 2 3

Products for CCL17 Gene

Sources for CCL17 Gene

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