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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL17 Gene

protein-coding GIFtS: 61
GCID: GC16P057438

chemokine (C-C motif) ligand 17

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA17)

Explore 67 diseases affiliated with
CCL17 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 17¹ ²		Thymus And Activation-Regulated Chemokine² ³
SCYA17¹ ² ³ ⁵		CC Chemokine TARC² ³
TARC¹ ² ³ ⁵		A-152E5.3²
ABCD-2¹ ²		C-C Motif Chemokine 17²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17¹ ²		T Cell-Directed CC Chemokine²
Small-Inducible Cytokine A17² ³

External Ids:	HGNC: 10615¹	Entrez Gene: 6361²	Ensembl: ENSG00000102970⁷	OMIM: 601520⁵	UniProtKB: Q92583³

Export aliases for CCL17 gene to outside databases

Previous GC identifers: GC16P047843 GC16P057498 GC16P057173 GC16P057214 GC16P055996 GC16P043306

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL17:

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family

of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins

characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T

lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8.

This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of

mature T cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583

Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development

in thymus and in trafficking and activation of mature T-cells. Binds to CCR4

Gene Wiki entry for CCL17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCL17 gene promoter:
STAT5B RelA CUTL1 C/EBPalpha PPAR-alpha CREB c-Rel deltaCREB FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL17 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL17

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q13

CCL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL17 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P057438: view genomic region (about GC identifiers)

Start:	57,438,679 bp from pter	End:	57,449,974 bp from pter
Size:	11,296 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583 (See protein sequence)

Recommended Name: C-C motif chemokine 17 precursor

Size: 94 amino acids; 10507 Da

Subcellular location: Secreted

Caution: Was originally (PubMed:9521068) thought to be a ligand for CCR8

2 PDB 3D structures from and Proteopedia for CCL17:

1NR2 (3D)

1NR4 (3D)

Secondary accessions: A0N0Q9 Q2M287

Explore the universe of human proteins at neXtProt for CCL17: NX_Q92583

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92583

CCL17 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002978.1

ENSEMBL proteins:

ENSP00000219244

Reactome Protein details: Q92583
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CCL17 Proteins Novus Biologicals CCL17 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL17
	Uscn Proteins for CCL17

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CCL17 for ontologies About GeneDecksing

CCL17 Antibody Products:

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	Novus Biologicals CCL17 Antibodies
	Search for Antibodies for CCL17 at Abcam
	Uscn Antibodies for CCL17
	ThermoFisher Antibodies for CCL17

Assay Products for CCL17:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL17

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL17 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q92583

ProtoNet protein and cluster: Q92583

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583

Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development

in thymus and in trafficking and activation of mature T-cells. Binds to CCR4

Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL17
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		SwitchGear 3'UTR luciferase reporter plasmid: CCL17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL17 (see all 7) OriGene shRNA RFP: CCL17 OriGene siRNA: CCL17
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL17

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CCL17 (NM_002987)
		Sino Biological Human cDNA Clone for CCL17
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL17
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL17

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL17
		Search LifeMap BioReagents cell lines for CCL17

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL17

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	9743322
GO:0008009	chemokine activity	IEA	--

CCL17 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CCL17:

Decreased G3BP1 protein expres

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ccl17):

immune system

CCL17 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL17 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 BioSystems Pathway for CCL17

IL4-mediated signaling events

5/6 Reactome Pathways for CCL17 (see all 6)

	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding

2 Kegg Pathways (Kegg details for CCL17):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCL17 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL17

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/26 Interacting proteins for CCL17 (Q92583³ ENSP00000219244⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCR4	P51679³, ENSP00000332659⁴	I2D: score=2 STRING: ENSP00000332659
CCR8	P51685³, ENSP00000326432⁴	I2D: score=1 STRING: ENSP00000326432
VCAM1	P19320³, ENSP00000294728⁴	I2D: score=4 STRING: ENSP00000294728
DARC	Q16570³, ENSP00000357103⁴	I2D: score=2 STRING: ENSP00000357103
CCL11	ENSP00000302234⁴	STRING: ENSP00000302234

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8702936
GO:0007267	cell-cell signaling	TAS	8702936

CCL17 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL17 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL17
10/17 Novoseek chemical compound relationships for CCL17 gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tarc	99.5	1017	15194145 (11), 14767451 (10), 12522366 (10), 12588369 (9) (see all 99)
larc	80.4	10	9365118 (3), 9153236 (1), 9169459 (1), 12239608 (1) (see all 7)
rantes	79.5	38	17460400 (2), 16802769 (2), 17165591 (2), 12832759 (2) (see all 30)
ccl3	68.5	6	12851650 (1), 16905241 (1), 17369706 (1), 17168792 (1) (see all 5)
[alcl]	50.3	7	11420464 (2), 12181269 (2)
olopatadine	49.5	6	15541638 (3), 15864020 (2)
ccl4	46.5	3	16905241 (1), 17369706 (1), 19421322 (1)
roxithromycin	39.9	5	19251402 (2), 14679761 (1)
il 10	30.1	3	15975968 (2), 11323220 (1)
allergens	28.2	4	17023689 (1), 17548604 (1), 15194145 (1), 17898016 (1)

Search CenterWatch for drugs/clinical trials and news about CCL17

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL17 gene:

NM_002987.2

Unigene Cluster for CCL17:

Chemokine (C-C motif) ligand 17

Hs.546294

Unigene Representative Sequence: NM_002987

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000219244(uc002elj.1 uc010ccz.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL17
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL17
		SwitchGear 3'UTR luciferase reporter plasmid: CCL17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL17 (see all 7) OriGene shRNA RFP: CCL17 OriGene siRNA: CCL17
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL17 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL17 (NM_002987)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL17

Additional cDNA sequence:

BC069107.1 BC112066.1 BC112068.1 D43767.1

1 DOTS entry:

DT.91916166

4 AceView cDNA sequences:

BC069107 NM_002987 D43767 BE061171

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCACAAAGG

About this image

CCL17 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCL17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL17

SOURCE GeneReport for Unigene cluster: Hs.546294

UniProtKB/Swiss-Prot: CCL17_HUMAN, Q92583

Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL17 (see all 7):

Antigen Presenting Cells in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL17 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL17

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CCL17

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL17 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccl17^{1 , 5}	chemokine (C-C motif) ligand 17^{1, 5}	73.7(n)¹ 64.44(a)¹		8 (46.85 cM)⁵ 20295¹ NM_011332.3¹ NP_035462.2¹ 94810453⁵
chicken (Gallus gallus)	Aves	CCL17⁶	Uncharacterized protein	46(a)	1 ↔ 1	11(770879-771850)

ENSEMBL Gene Tree for CCL17 (if available)
TreeFam Gene Tree for CCL17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL17 gene

18/23 SIMAP similar genes for CCL17 using alignment to 1 protein entry: CCL17_HUMAN(see all similar genes):

CCL23 CCL15 CCL14 CCL26 CCL16 CCL8

CCL3 CCL11 CCL3L1 CCL3L3 CCL5 CCL22

CCL7 MCP-3 CCL18 CX3CL1 CCL2 CCL4L2

CCL17 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CCL17
PGOHUM00000248925

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190760487^1,2		--	57436775(+)	`GTGCCA/GAGATA`	1	--	us2k¹		0	--	--	--	--
rs72792965^1,2	C,F,	--	57436888(+)	`ACATAA/CGTAAG`	1	--	us2k¹		1		NA	120
rs182997685^1,2		--	57437056(+)	`ATTATA/CTATAA`	1	--	us2k¹		0	--	--	--	--
rs188069237^1,2		--	57437099(+)	`TATAAC/TATATA`	1	--	us2k¹		0	--	--	--	--
rs11642196^1,2	H	--	57437208(+)	`atataA/Taatat`	1	--	us2k¹		0	--	--	--	--
rs11641095^1,2	H	--	57437209(+)	`tatatA/Tatata`	1	--	us2k¹		0	--	--	--	--
rs192525648^1,2		--	57437239(+)	`TATAAC/TATATA`	1	--	us2k¹		0	--	--	--	--
rs185521180^1,2		--	57437294(+)	`ACATAC/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs187649287^1,2		--	57437301(+)	`TTATAG/TATAAT`	1	--	us2k¹		0	--	--	--	--
rs192616288^1,2		--	57437342(+)	`AATATA/GTATTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL17 (57438679 - 57449974 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCL17: --
Human Gene Mutation Database (HGMD): CCL17

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL17

DNA2.0 Custom Variant and Variant Library Synthesis for CCL17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL17 for disorders           About GeneDecksing

OMIM gene information: 601520    OMIM disorders: --

20/67 diseases for CCL17 (see all 67):    About MalaCards

lymphomatoid papulosis toxic epidermal necrolysis stevens-johnson syndrome anaplastic large cell lymphoma

diffuse large b-cell lymphoma human t-cell leukemia virus type 1 allergic bronchopulmonary aspergillosis otitis media

mycosis fungoides b-cell lymphomas paragonimiasis vernal keratoconjunctivitis

allergic rhinitis erythema multiforme bullous pemphigoid lupus erythematosus

bronchiolitis obliterans pulmonary fibrosis cutaneous lupus erythematosus idiopathic pulmonary fibrosis

6 diseases from the University of Copenhagen DISEASES database for CCL17:

Atopic dermatitis Asthma Eosinophilia Hypersensitivity reaction type I disease

Allergic rhinitis Allergic contact dermatitis

10/40 Novoseek disease relationships for CCL17 gene (see all 40) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatitis atopic	80.3	34	10998136 (4), 12715916 (2), 15194145 (2), 11323220 (2) (see all 21)
skin diseases	56	6	16859899 (3)
pneumonia eosinophilic	53.6	8	11956056 (3), 15751278 (1), 12757454 (1)
asthma	51.5	20	16387595 (2), 16543550 (2), 12645858 (2), 11929424 (2) (see all 13)
inflammation	49.6	25	17023689 (3), 15993846 (2), 17848804 (1), 11737030 (1) (see all 19)
eczema	45	3	16499646 (2), 12269940 (1)
fibrosis idiopathic pulmonary	43.4	4	11956056 (1), 15383605 (1), 19715610 (1)
hodgkin disease	42.3	11	15994922 (4), 19591376 (1), 11420464 (1), 18541724 (1) (see all 5)
bronchoalveolar lavage fluid	42	7	12757454 (2), 12750406 (1), 16387607 (1), 11306430 (1) (see all 5)
allergic rhinitis	41.8	7	16261952 (3), 11737045 (2), 12445798 (1), 17982926 (1)

Genetic Association Database (GAD): CCL17
Human Genome Epidemiology (HuGE) Navigator: CCL17 (8 documents)

Export disorders for CCL17 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCL17 gene, integrated from 9 sources (see all 307):
(articles sorted by number of sources associating them with CCL17)

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Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PubMed id 8702936)^{1, 2, 3} Imai T.... Yoshie O. (1996)
Structures of thymus and activation-regulated chemokine (TARC). (PubMed id 12832759)^{1, 2, 9} Asojo O.A.... Lubkowski J. (2003)
The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PubMed id 15500644)^{1, 4, 9} Tsunemi Y....Tamaki K. (2004)
The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)^{1, 2, 9} Garlisi C.G....Umland S.P. (1999)
Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)^{1, 2, 9} Bernardini G....Napolitano M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosus. (PubMed id 14677179)^{1, 4} Okamoto H....Kamatani N. (2003)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)
Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13. (PubMed id 9070951)^{1, 3} Nomiyama H....Yoshie O. (1997)
Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. (PubMed id 14767451)^{1, 9} Hijnen D....Knol E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6361	HGNC: 10615	AceView: CCL17	Ensembl:ENSG00000102970	euGenes: HUgn6361
ECgene: CCL17	Kegg: 6361	H-InvDB: CCL17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCL17	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CCL17

Intellectual Property for CCL17 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCL17 gene:
Search GeneIP for patents involving CCL17

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chemokine (C-C motif) ligand 17

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CCL17 Gene

chemokine (C-C motif) ligand 17

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