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Aliases for CCL16 Gene

Aliases for CCL16 Gene

  • Chemokine (C-C Motif) Ligand 16 2 3
  • SCYA16 3 4 6
  • NCC4 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16 2 3
  • Lymphocyte And Monocyte Chemoattractant 3 4
  • Small-Inducible Cytokine A16 3 4
  • Liver-Expressed Chemokine 3 4
  • IL-10-Inducible Chemokine 3 4
  • Chemokine LEC 3 4
  • Monotactin-1 3 4
  • ILINCK 3 4
  • HCC-4 3 4
  • Mtn-1 3 4
  • LCC-1 3 4
  • NCC-4 3 4
  • LMC 3 4
  • C-C Motif Chemokine 16 3
  • Liver CC Chemokine-1 3
  • New CC Chemokine 4 3
  • Chemokine CC-4 4
  • CKb12 3
  • SCYL4 3
  • LEC 3

External Ids for CCL16 Gene

Previous HGNC Symbols for CCL16 Gene

  • SCYA16

Previous GeneCards Identifiers for CCL16 Gene

  • GC17M034073
  • GC17M036339
  • GC17M034152
  • GC17M034449
  • GC17M031327
  • GC17M034303
  • GC17M030488

Summaries for CCL16 Gene

Entrez Gene Summary for CCL16 Gene

  • This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL16 Gene

CCL16 (Chemokine (C-C Motif) Ligand 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity and chemoattractant activity.

UniProtKB/Swiss-Prot for CCL16 Gene

  • Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL16 Gene

Genomics for CCL16 Gene

Regulatory Elements for CCL16 Gene

Genomic Location for CCL16 Gene

Start:
35,976,493 bp from pter
End:
35,982,360 bp from pter
Size:
5,868 bases
Orientation:
Minus strand

Genomic View for CCL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL16 Gene

Proteins for CCL16 Gene

  • Protein details for CCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15467-CCL16_HUMAN
    Recommended name:
    C-C motif chemokine 16
    Protein Accession:
    O15467
    Secondary Accessions:
    • Q4KKU0

    Protein attributes for CCL16 Gene

    Size:
    120 amino acids
    Molecular mass:
    13600 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL16 Gene

Proteomics data for CCL16 Gene at MOPED

Post-translational modifications for CCL16 Gene

No Post-translational modifications

Other Protein References for CCL16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL16 Gene

Domains for CCL16 Gene

Gene Families for CCL16 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL16 Gene

Suggested Antigen Peptide Sequences for CCL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15467

UniProtKB/Swiss-Prot:

CCL16_HUMAN :
  • O15467
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL16: view

Function for CCL16 Gene

Molecular function for CCL16 Gene

UniProtKB/Swiss-Prot Function: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES
UniProtKB/Swiss-Prot Induction: By IL10/interleukin-10

Gene Ontology (GO) - Molecular Function for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
GO:0042056 chemoattractant activity IDA 15001559
genes like me logo Genes that share ontologies with CCL16: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL16 Gene

Localization for CCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL16 Gene COMPARTMENTS Subcellular localization image for CCL16 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL16: view

Pathways for CCL16 Gene

genes like me logo Genes that share pathways with CCL16: view

Interacting Proteins for CCL16 Gene

Selected Interacting proteins: O15467-CCL16_HUMAN for CCL16 Gene via I2D

Gene Ontology (GO) - Biological Process for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 9642106
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007154 cell communication TAS 9642106
GO:0007267 cell-cell signaling TAS 9642106
genes like me logo Genes that share ontologies with CCL16: view

Compounds for CCL16 Gene

(1) HMDB Compounds for CCL16 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for CCL16 Gene

Compound -log(P) Hits PubMed IDs
rantes 77.8 8
ccl3 66 1
calcium 0 4
genes like me logo Genes that share compounds with CCL16: view

Transcripts for CCL16 Gene

mRNA/cDNA for CCL16 Gene

Unigene Clusters for CCL16 Gene

Chemokine (C-C motif) ligand 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL16 Gene

No ASD Table

Relevant External Links for CCL16 Gene

GeneLoc Exon Structure for
CCL16
ECgene alternative splicing isoforms for
CCL16

Expression for CCL16 Gene

mRNA expression in normal human tissues for CCL16 Gene

mRNA differential expression in normal tissues according to GTEx for CCL16 Gene

This gene is overexpressed in Liver (42.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCL16 Gene

SOURCE GeneReport for Unigene cluster for CCL16 Gene Hs.10458

mRNA Expression by UniProt/SwissProt for CCL16 Gene

O15467-CCL16_HUMAN
Tissue specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones
genes like me logo Genes that share expressions with CCL16: view

Orthologs for CCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL16 35
  • 99.17 (n)
  • 99.17 (a)
cow
(Bos Taurus)
Mammalia CCL16 35
  • 85 (n)
  • 74 (a)
dog
(Canis familiaris)
Mammalia CCL16 35
  • 81.16 (n)
  • 63.04 (a)
Species with no ortholog for CCL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL16 Gene

ENSEMBL:
Gene Tree for CCL16 (if available)
TreeFam:
Gene Tree for CCL16 (if available)

Paralogs for CCL16 Gene

genes like me logo Genes that share paralogs with CCL16: view

No data available for Paralogs for CCL16 Gene

Variants for CCL16 Gene

Sequence variations from dbSNP and Humsavar for CCL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs854680 -- 35,982,014(-) TGACA(G/T)GAAAG intron-variant, upstream-variant-2KB
rs917015 -- 35,978,489(+) GACTT(A/G)GTTAT intron-variant
rs1127790 -- 35,977,211(-) CCTCC(C/T)GAGTA utr-variant-3-prime
rs1734967 -- 35,976,945(-) CCATT(C/T)TAAAT utr-variant-3-prime
rs2063979 -- 35,976,530(-) CCCAA(A/G)CATGC utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCL16 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850

Relevant External Links for CCL16 Gene

HapMap Linkage Disequilibrium report
CCL16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL16 Gene

Disorders for CCL16 Gene

(1) Novoseek inferred disease relationships for CCL16 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for CCL16

Genetic Association Database (GAD)
CCL16
Human Genome Epidemiology (HuGE) Navigator
CCL16
genes like me logo Genes that share disorders with CCL16: view

No data available for UniProtKB/Swiss-Prot for CCL16 Gene

Publications for CCL16 Gene

  1. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. (PMID: 9596672) Hedrick J.A. … Zlotnik A. (Blood 1998) 3 4 23
  2. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. (PMID: 9642106) Youn B.-S. … Kwon B.S. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 4 23
  4. Genomic organization of the genes for human and mouse CC chemokine LEC. (PMID: 10235110) Fukuda S. … Nomiyama H. (DNA Cell Biol. 1999) 3 4 23
  5. Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. (PMID: 10671294) Yang J.-Y. … Widmer U. (Cytokine 2000) 3 4 23

Products for CCL16 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antigen Presenting Cells in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL16
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL16
  • Block miRNA regulation of CCL16 using miScript Target Protectors

Sources for CCL16 Gene

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