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CCL16 Gene

protein-coding   GIFtS: 57
GCID: GC17M034303

Chemokine (C-C Motif) Ligand 16

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 16)
(Previous symbol: SCYA16)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 161 2     NCC-42 3
SCYA161 2 3 5     IL-10-Inducible Chemokine2 3
NCC42 3 5     CKb122
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 161 2     LEC2
Chemokine CC-42 3     Mtn-12
Chemokine LEC2 3     SCYL42
Liver-Expressed Chemokine2 3     C-C Motif Chemokine 162
Lymphocyte And Monocyte Chemoattractant2 3     Liver CC Chemokine-12
Small-Inducible Cytokine A162 3     monotactin-12
HCC-42 3     New CC Chemokine 42
ILINCK2 3     MTN-13
LCC-12 3     Monotactin-13
LMC2 3     

External Ids:    HGNC: 106141   Entrez Gene: 63602   Ensembl: ENSG000001615737   OMIM: 6013945   UniProtKB: O154673   

Export aliases for CCL16 gene to outside databases

Previous GC identifers: GC17M034073 GC17M036339 GC17M034152 GC17M034449 GC17M031327 GC17M030488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL16 Gene:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of
secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for
lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity
and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CCL16 Gene:
CCL16 (chemokine (C-C motif) ligand 16) is a protein-coding gene. GO annotations related to this gene include chemoattractant activity and chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL16_HUMAN, O15467
Function: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent
myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows
chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces
a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL16 gene promoter:
         GR   LHX3b/Lhx3b   GR-beta   MyoD   E4BP4   YY1   C/EBPalpha   HOXA5   LHX3a/Lhx3a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL16 promoter sequence
   Search Chromatin IP Primers for CCL16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL16 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034303:  view genomic region     (about GC identifiers)

Start:
34,303,529 bp from pter      End:
34,308,532 bp from pter
Size:
5,004 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL16_HUMAN, O15467 (See protein sequence)
Recommended Name: C-C motif chemokine 16 precursor  
Size: 120 amino acids; 13600 Da
Secondary accessions: Q4KKU0

Explore the universe of human proteins at neXtProt for CCL16: NX_O15467

Explore proteomics data for CCL16 at MOPED


See CCL16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004581.1  
ENSEMBL proteins: 
 ENSP00000431339   ENSP00000293275   ENSP00000466279  
Reactome Protein details: O15467

CCL16 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for CCL16 (CCL16/HCC-4)
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OriGene Purified Protein for CCL16
OriGene Protein Over-expression Lysate for CCL16
OriGene Custom MassSpec
OriGene Custom Protein Services for CCL16
GenScript Purified and Recombinant Proteins for CCL16
Novus Biologicals CCL16 Proteins
Novus Biologicals CCL16 Lysate
Sino Biological Recombinant Protein for CCL16
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ProSpec Recombinant Protein for CCL16
Cloud-Clone Corp. Proteins for CCL16

 
Search eBioscience for Proteins for CCL16 

CCL16 Antibody Products:

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R&D Systems Antibodies for CCL16 (CCL16/HCC-4)
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Novus Biologicals CCL16 Antibodies
Abcam antibodies for CCL16 (Q4KKU0, O15467)
Cloud-Clone Corp. Antibodies for CCL16
ThermoFisher Antibodies for CCL16
LSBio Antibodies in human, mouse, rat for CCL16

CCL16 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL16
R&D Systems ELISAs for CCL16 (CCL16/HCC-4)
GenScript Custom Assay Services for CCL16
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CCL16
Cloud-Clone Corp. CLIAs for CCL16
Search eBioscience for ELISAs for CCL16 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry O15467

ProtoNet protein and cluster: O15467

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL16_HUMAN, O15467
Similarity: Belongs to the intercrine beta (chemokine CC) family


Find genes that share domains with CCL16           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL16_HUMAN, O15467
Function: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent
myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows
chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces
a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES
Induction: By IL10/interleukin-10

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IEA--
GO:0042056chemoattractant activity IDA15001559
     
Find genes that share ontologies with CCL16           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL16
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL16

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL16
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL16

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CCL16 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate CCL16:
hsa-miR-539 hsa-miR-2115 hsa-miR-1238 hsa-miR-7
SwitchGear 3'UTR luciferase reporter plasmidCCL16 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CCL16
Predesigned siRNA for gene silencing in human, mouse, rat CCL16

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL16

Clone
Products:
     
OriGene clones in human, mouse for CCL16 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL16 (NM_004590)
Sino Biological Human cDNA Clone for CCL16
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL16

Cell Line
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GenScript Custom overexpressing Cell Line Services for CCL16
Browse ESI BIO Cell Lines and PureStem Progenitors for CCL16 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL16


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CCL16_HUMAN, O15467: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CCL16           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCL16 About   (see all 10)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
4TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
5Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44


Find genes that share SuperPaths with CCL16           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCL16
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL16 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway


2 Reactome Pathways for CCL16
    Chemokine receptors bind chemokines
G alpha (i) signalling events


2 Kegg Pathways  (Kegg details for CCL16):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL16: 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CCL16

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCL16 (O154673 ENSP000002932754) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
InteractantInteraction Details
GeneCardExternal ID(s)
CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
HRH4Q9H3N83, ENSP000002569064I2D: score=1 STRING: ENSP00000256906
CCR1P322463, ENSP000002961404I2D: score=2 STRING: ENSP00000296140
CCR2P415973, ENSP000002923014I2D: score=1 STRING: ENSP00000292301
CCR5P516813, ENSP000002923034I2D: score=2 STRING: ENSP00000292303
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis TAS9642106
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0007154cell communication TAS9642106
GO:0007267cell-cell signaling TAS9642106

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCL16

1 HMDB Compound for CCL16    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

3 Novoseek inferred chemical compound relationships for CCL16 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rantes 77.8 9 10213461 (3), 10910894 (1), 15832427 (1), 15001559 (1) (see all 6)
ccl3 66 1 16226254 (1)
calcium 0 4 16226254 (2), 11470772 (2)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCL16 gene: 
NM_004590.2  

Unigene Cluster for CCL16:

Chemokine (C-C motif) ligand 16
Hs.10458  [show with all ESTs]
Unigene Representative Sequence: AB007454
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000483259 ENST00000293275(uc002hkl.3 uc002hkm.3) ENST00000586567

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CCL16 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate CCL16:
hsa-miR-539 hsa-miR-2115 hsa-miR-1238 hsa-miR-7
SwitchGear 3'UTR luciferase reporter plasmidCCL16 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CCL16
Predesigned siRNA for gene silencing in human, mouse, rat CCL16
Clone
Products:
     
OriGene clones in human, mouse for CCL16 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL16 (NM_004590)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL16
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CCL16
OriGene qSTAR qPCR primer pairs in human, mouse for CCL16
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL16
  QuantiTect SYBR Green Assays in human, mouse, rat CCL16
  QuantiFast Probe-based Assays in human, mouse, rat CCL16

Additional mRNA sequence: 

AB007454.1 AF039955.1 AF055467.1 BC099662.3 U91746.1 

2 DOTS entries:

DT.406665  DT.120953741 

Selected AceView cDNA sequences (see all 135):

AW827147 BI837334 AF039955 H22089 BM677878 BX284026 NM_005064 BC045165 
NM_004590 AA515108 BC050647 NM_032963 AK122606 AA345971 AA699362 AW117461 
CD743105 BC038289 NM_145898 NM_032964 BQ186446 BM853193 BQ026575 U58914 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCL16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATAAATAA
CCL16 Expression
About this image


CCL16 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone marrow-derived mesenchymal stem cells (Stempeucel)
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells (Stempeucel)
 
 Liver (Hepatobiliary System)
CCL16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCL16 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.10458

UniProtKB/Swiss-Prot: CCL16_HUMAN, O15467
Tissue specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and
IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells,
and some T-cell clones

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL16: 
          Antigen Presenting Cells in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CCL16
OriGene qSTAR qPCR primer pairs in human, mouse for CCL16
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL16
QuantiTect SYBR Green Assays in human, mouse, rat CCL16
QuantiFast Probe-based Assays in human, mouse, rat CCL16
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCL16 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia CCL161 chemokine (C-C motif) ligand 16 81.16(n)
63.04(a)
  480604  XM_537724.4  XP_537724.3 
chicken
(Gallus gallus)
Aves GGCL16
Gallus gallus chemokine-like ligand 1 (GGCL1), mRN...
28(a)
1 → many
19(352190-372634)
zebrafish
(Danio rerio)
Actinopterygii ZGC:1937066
chemokine CCL-C25y-like (LOC100000034), mRNA
29(a)
1 → many
25(25902180-25904281) ENSDARG00000070378


ENSEMBL Gene Tree for CCL16 (if available)
TreeFam Gene Tree for CCL16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCL16 gene
CCL152  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  CCL52  
CCL232  CCL3L32  CCL15-CCL142  CCL182  CCL42  
Selected SIMAP similar genes for CCL16 using alignment to 3 protein entries:     CCL16_HUMAN (see all proteins) (see all similar genes):
KLHDC1    CCL3    CCL3L1    CCL3L3    CCL14    CCL4
CCL4L2    LOC728835    CCL4L1    CCL17    CCL18    CCL7
MCP-3    CCL15    CCL20    CCL21    CCL19    CCL8

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCL16 (see all 192)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1449311991,2
--34303044(+) TCACCC/GTGTTA 1 -- ds50010--------
rs1860120361,2
--34303060(+) GATGGG/TCTCGA 1 -- ds50010--------
rs2010831431,2
C--34303085(+) CCCCC-/CTCGGC 1 -- ds50010--------
rs1479199861,2
C--34303131(+) GCCACC/TGCGCC 1 -- ds50010--------
rs1144234621,2
F--34303132(+) CCACCG/ACGCCG 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs1903320221,2
--34303151(+) AGGAGC/GCTCGG 1 -- ds50010--------
rs1812043401,2
--34303169(+) CAACAA/TGGCCA 1 -- ds50010--------
rs765702611,2
C--34303283(+) AATTAC/TCTGTC 1 -- ds50013Minor allele frequency- T:0.06NA EA 242
rs803296141,2
C--34303312(+) TTACCT/CGGCTT 1 -- ds50015Minor allele frequency- C:0.14NA WA EA 362
rs20639791,2
C,F,O,A,H--34303566(-) CCCAAG/ACATGC 1 -- ut3121Minor allele frequency- A:0.43MN NS EA NA CSA WA 2529

HapMap Linkage Disequilibrium report for CCL16 (34303529 - 34308532 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CCL16:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833427CNV Loss17160897
nsv833424CNV Gain17160897
nsv428340CNV Gain18775914
dgv945e1CNV Complex17122850
dgv946e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCL16
DNA2.0 Custom Variant and Variant Library Synthesis for CCL16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601394    OMIM disorders: --


Find genes that share disorders with CCL16           About GenesLikeMe

1 Novoseek inferred disease relationship for CCL16 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 5 12843794 (2), 10706711 (1), 15171818 (1)

Genetic Association Database (GAD): CCL16
Human Genome Epidemiology (HuGE) Navigator: CCL16 (6 documents)

Export disorders for CCL16 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCL16 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with CCL16)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. (PubMed id 10671294)1, 2, 9 Yang J.-Y.... Widmer U. (Cytokine 2000)
  2. Genomic organization of the genes for human and mouse CC chemokine LEC. (PubMed id 10235110)1, 2, 9 Fukuda S.... Nomiyama H. (DNA Cell Biol. 1999)
  3. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. (PubMed id 9642106)1, 2, 9 Youn B.-S.... Kwon B.S. (Biochem. Biophys. Res. Commun. 1998)
  4. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. (PubMed id 9596672)1, 2, 9 Hedrick J.A.... Zlotnik A. (Blood 1998)
  5. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (J. Interferon Cytokine Res. 1999)
  6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  8. Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazil. (PubMed id 17122780)1, 4 Jamieson S.E....Blackwell J.M. (Genes Immun. 2007)
  9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6360 HGNC: 10614 AceView: CCL16andCCL23 Ensembl:ENSG00000161573 euGenes: HUgn6360
ECgene: CCL16 Kegg: 6360 H-InvDB: CCL16

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCL16 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CCL16

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCL16 gene:
Search GeneIP for patents involving CCL16

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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