Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL16 Gene

Aliases for CCL16 Gene

  • C-C Motif Chemokine Ligand 16 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16 2 3
  • Lymphocyte And Monocyte Chemoattractant 3 4
  • Chemokine (C-C Motif) Ligand 16 2 3
  • Small-Inducible Cytokine A16 3 4
  • Liver-Expressed Chemokine 3 4
  • IL-10-Inducible Chemokine 3 4
  • Chemokine LEC 3 4
  • Monotactin-1 3 4
  • SCYA16 3 4
  • ILINCK 3 4
  • Mtn-1 3 4
  • HCC-4 3 4
  • LCC-1 3 4
  • NCC-4 3 4
  • NCC4 3 4
  • LMC 3 4
  • C-C Motif Chemokine 16 3
  • Liver CC Chemokine-1 3
  • New CC Chemokine 4 3
  • Chemokine CC-4 4
  • CKb12 3
  • SCYL4 3
  • LEC 3

External Ids for CCL16 Gene

Previous HGNC Symbols for CCL16 Gene

  • SCYA16

Previous GeneCards Identifiers for CCL16 Gene

  • GC17M034073
  • GC17M036339
  • GC17M034152
  • GC17M034449
  • GC17M031327
  • GC17M034303
  • GC17M030488

Summaries for CCL16 Gene

Entrez Gene Summary for CCL16 Gene

  • This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL16 Gene

CCL16 (C-C Motif Chemokine Ligand 16) is a Protein Coding gene. Diseases associated with CCL16 include Corneal Dystrophy, Lisch Epithelial. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include chemokine activity and chemoattractant activity. An important paralog of this gene is CCL14.

UniProtKB/Swiss-Prot for CCL16 Gene

  • Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL16 Gene

Genomics for CCL16 Gene

Regulatory Elements for CCL16 Gene

Enhancers for CCL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F035981 0.9 ENCODE 0.8 +0.9 872 1.4 ELF3 ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA YY1 MIXL1 SP5 SLFN12 CCL16 GC17M036032
GH17F035976 0.7 Ensembl 0.4 +6.7 6689 0.4 BCOR CTCF ZNF654 REST ZNF2 RAD21 ZNF121 ZNF316 ZNF580 SMC3 CCL18 GC17M036032 CCL16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL16 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL16 Gene

Chromosome:
17
Start:
35,976,493 bp from pter
End:
35,982,889 bp from pter
Size:
6,397 bases
Orientation:
Minus strand

Genomic View for CCL16 Gene

Genes around CCL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL16 Gene

Proteins for CCL16 Gene

  • Protein details for CCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15467-CCL16_HUMAN
    Recommended name:
    C-C motif chemokine 16
    Protein Accession:
    O15467
    Secondary Accessions:
    • Q4KKU0

    Protein attributes for CCL16 Gene

    Size:
    120 amino acids
    Molecular mass:
    13600 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL16 Gene

Post-translational modifications for CCL16 Gene

No Post-translational modifications

Other Protein References for CCL16 Gene

No data available for DME Specific Peptides for CCL16 Gene

Domains & Families for CCL16 Gene

Gene Families for CCL16 Gene

Protein Domains for CCL16 Gene

Suggested Antigen Peptide Sequences for CCL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15467

UniProtKB/Swiss-Prot:

CCL16_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL16: view

Function for CCL16 Gene

Molecular function for CCL16 Gene

UniProtKB/Swiss-Prot Function:
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
UniProtKB/Swiss-Prot Induction:
By IL10/interleukin-10.

Gene Ontology (GO) - Molecular Function for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA --
GO:0042056 chemoattractant activity IDA 15001559
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL16: view
genes like me logo Genes that share phenotypes with CCL16: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL16 Gene

Localization for CCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL16 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL16: view

Pathways & Interactions for CCL16 Gene

genes like me logo Genes that share pathways with CCL16: view

Interacting Proteins for CCL16 Gene

Selected Interacting proteins: O15467-CCL16_HUMAN for CCL16 Gene via IID

Gene Ontology (GO) - Biological Process for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA,TAS 9642106
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007154 cell communication TAS 9642106
genes like me logo Genes that share ontologies with CCL16: view

No data available for SIGNOR curated interactions for CCL16 Gene

Drugs & Compounds for CCL16 Gene

(2) Drugs for CCL16 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CCL16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL16: view

Transcripts for CCL16 Gene

Unigene Clusters for CCL16 Gene

Chemokine (C-C motif) ligand 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL16 Gene

No ASD Table

Relevant External Links for CCL16 Gene

GeneLoc Exon Structure for
CCL16
ECgene alternative splicing isoforms for
CCL16

Expression for CCL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL16 Gene

mRNA differential expression in normal tissues according to GTEx for CCL16 Gene

This gene is overexpressed in Liver (x42.2).

Protein differential expression in normal tissues from HIPED for CCL16 Gene

This gene is overexpressed in Plasma (50.0) and Serum (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL16 Gene



Protein tissue co-expression partners for CCL16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL16 Gene:

CCL16

SOURCE GeneReport for Unigene cluster for CCL16 Gene:

Hs.10458

mRNA Expression by UniProt/SwissProt for CCL16 Gene:

O15467-CCL16_HUMAN
Tissue specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
genes like me logo Genes that share expression patterns with CCL16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCL16 Gene

Orthologs for CCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL16 34
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia CCL16 34
  • 85 (n)
dog
(Canis familiaris)
Mammalia CCL16 34
  • 81.16 (n)
Species where no ortholog for CCL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL16 Gene

ENSEMBL:
Gene Tree for CCL16 (if available)
TreeFam:
Gene Tree for CCL16 (if available)

Paralogs for CCL16 Gene

genes like me logo Genes that share paralogs with CCL16: view

Variants for CCL16 Gene

Sequence variations from dbSNP and Humsavar for CCL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10445391 -- 35,979,070(+) ttgca(A/G)tgagc intron-variant
rs11080368 -- 35,978,035(+) TTAGC(A/C)ACTGC intron-variant
rs11080369 -- 35,978,128(+) ATCTA(A/C)AAGGA intron-variant
rs111316280 -- 35,978,236(+) AGGTG(A/G/T)ATGGG reference, missense
rs111361236 -- 35,983,021(+) CCATC(-/CATT)CCTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL16 Gene

Variant ID Type Subtype PubMed ID
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL16 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL16 Gene

Disorders for CCL16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCL16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, lisch epithelial
  • lisch epithelial corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search CCL16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL16

Genetic Association Database (GAD)
CCL16
Human Genome Epidemiology (HuGE) Navigator
CCL16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL16
genes like me logo Genes that share disorders with CCL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL16 Gene

Publications for CCL16 Gene

  1. Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. (PMID: 10671294) Yang J.-Y. … Widmer U. (Cytokine 2000) 3 4 22 64
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 4 22 64
  3. Genomic organization of the genes for human and mouse CC chemokine LEC. (PMID: 10235110) Fukuda S. … Nomiyama H. (DNA Cell Biol. 1999) 3 4 22 64
  4. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. (PMID: 9596672) Hedrick J.A. … Zlotnik A. (Blood 1998) 3 4 22 64
  5. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. (PMID: 9642106) Youn B.-S. … Kwon B.S. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64

Products for CCL16 Gene

Sources for CCL16 Gene

Content
Loading form....