CCL16 Gene

Aliases
for CCL16 gene

Previous GC identifers: GC17M034073 GC17M036339 GC17M034152 GC17M034449 GC17M031327 GC17M030488

Summaries
for CCL16 gene

Genomic Views
for CCL16 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010799.15  

SwitchGear Promoter luciferase reporter plasmid: CCL16 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL16

CCL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034303:  view genomic region     (about GC identifiers)

Proteins
for CCL16 gene

Explore the universe of human proteins at neXtProt for CCL16: NX_O15467

CCL16 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL16 (CCL16/HCC-4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CCL16 OriGene Custom Protein Services for CCL16
	GenScript Purified and Recombinant Proteins for CCL16
	Novus Biologicals CCL16 Proteins Novus Biologicals CCL16 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL16
	Uscn Proteins for CCL16

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL16 (CCL16/HCC-4)
	OriGene Antibodies (see all 2): CCL16 OriGene Custom Antibody Services for CCL16
	GenScript Custom Superior Antibodies Services for CCL16
	Novus Biologicals CCL16 Antibodies
	Abcam antibodies for CCL16
	Uscn Antibodies for CCL16
	ThermoFisher Antibodies for CCL16

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CCL16 (CCL16/HCC-4)
	GenScript Custom Assay Services for CCL16
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL16

Protein Domains /
Families
for CCL16 gene

ProtoNet protein and cluster: O15467

Function
for CCL16 gene

miRNA Products:		OriGene 3'-UTR Clone: CCL16 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL16
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CCL16:
		hsa-miR-539 hsa-miR-2115 hsa-miR-1238 hsa-miR-7
		SwitchGear 3'UTR luciferase reporter plasmid: CCL16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL16 OriGene shRNA RFP: CCL16 OriGene siRNA: CCL16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL16

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CCL16

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL16 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL16 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL16 (NM_004590)
		Sino Biological Human cDNA Clone for CCL16
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL16

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL16
		Search LifeMap BioReagents cell lines for CCL16

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL16

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for CCL16 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/12 pathways (see all 12) PEDF Induced Signaling 1.00 STAT3 Pathway 0.47 MIF Mediated Glucocorticoid Regulation 0.73 Endothelin-1 Signaling Pathway 0.44 MIF Regulation of Innate Immune Cells 0.71 NFAT Signaling and Lymphocyte Interactions 0.37 IL-6 Pathway 0.61 PGC1Alpha Pathway 0.33
2	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JNK Pathway 0.50 MAPK Family Pathway 0.60 Regulation of eIF4 and p70S6K 0.43 JAK-STAT Pathway 0.57 SOCS Pathway 0.29
3	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 Peptide ligand-binding receptors 0.61 GPCR ligand binding 0.75 G alpha (i) signalling events 0.44
4	Akt Signaling	Akt Signaling 1.00 Tec Kinases Signaling 0.55 p38 Signaling 0.60
5	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL16

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

5/8        Reactome Pathways for CCL16

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2         Kegg Pathways  (Kegg details for CCL16)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for CCL16 gene

Transcripts
for CCL16 gene

Expression
for CCL16 gene

CCL16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATAAATAA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCL16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL16

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL16

Orthologs
for CCL16 gene

Paralogs
for CCL16 gene

Paralogs for CCL16 gene

CCL15²  CCL2²  CCL14²  CCL24²  CCL4L1²  CCL11²  CCL7²  CCL4L2²  

CCL3L1²  CCL5²  CCL23²  CCL3L3²  CCL4²  CCL8²  CCL13²  CCL26²  

CCL3²  CCL18²  

18/24 SIMAP similar genes for CCL16 using alignment to 3 protein entries:     CCL16_HUMAN (see all proteins) (see all similar genes):

KLHDC1    CCL3    CCL3L1    CCL3L3    CCL14    CCL4

CCL4L2    LOC728835    CCL4L1    CCL17    CCL18    CCL7

MCP-3    CCL15    CCL20    CCL21    CCL19    CCL8

CCL16 for paralogs           About GeneDecksing

Genomic Variants
for CCL16 gene

10/154 NCBI SNPs in CCL16 are shown (see all 154)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1449311991,2		--	34303044(+)	TCACCC/GTGTTA	1	--	ds5001		0	--	--	--	--
rs1860120361,2		--	34303060(+)	GATGGG/TCTCGA	1	--	ds5001		0	--	--	--	--
rs1479199861,2		--	34303131(+)	GCCACC/TGCGCC	1	--	ds5001		0	--	--	--	--
rs1144234621,2	F,	--	34303132(+)	CCACCG/ACGCCG	1	--	ds5001		1		WA	118
rs1903320221,2		--	34303151(+)	AGGAGC/GCTCGG	1	--	ds5001		0	--	--	--	--
rs1812043401,2		--	34303169(+)	CAACAA/TGGCCA	1	--	ds5001		0	--	--	--	--
rs765702611,2	C,	--	34303283(+)	AATTAC/TCTGTC	1	--	ds5001		3		NA EA	242
rs803296141,2	C,	--	34303312(+)	TTACCT/CGGCTT	1	--	ds5001		5		NA WA EA	362
rs20639791,2	C,F,O,A,H,	--	34303566(-)	CCCAAG/ACATGC	1	--	ut31		21		MN NS EA NA CSA WA	2529
rs1453118551,2	C,	--	34303677(+)	CTTCT-/TCTCTCT	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL16 (34303529 - 34308532 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCL16
     1 CNV: 4031

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL16

DNA2.0 Custom Variant and Variant Library Synthesis for CCL16

Disorders / Diseases
for CCL16 gene

16 diseases for CCL16

1 Novoseek disease relationship for CCL16 gene    About this table

Publications
for CCL16 gene

PubMed articles for CCL16 gene, integrated from 9 sources (see all 36): (articles sorted by number of sources associating them with CCL16)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. (PubMed id 10671294)^{1, 2, 9} Yang J.-Y.... Widmer U. (2000)
2. Genomic organization of the genes for human and mouse CC chemokine LEC. (PubMed id 10235110)^{1, 2, 9} Fukuda S.... Nomiyama H. (1999)
3. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. (PubMed id 9642106)^{1, 2, 9} Youn B.-S.... Kwon B.S. (1998)
4. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. (PubMed id 9596672)^{1, 2, 9} Hedrick J.A.... Zlotnik A. (1998)
5. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)^{1, 2, 9} Nomiyama H.... Yoshie O. (1999)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC. (PubMed id 9545580)^{1, 2} Shoudai K.... Nomiyama H. (1998)
8. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)^{1, 3} Naruse K....Miura R. (1996)
9. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. (PubMed id 10910894)^{1, 9} Howard O.M....Oppenheim J.J. (2000)
10. Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. (PubMed id 16226254)^{1, 9} Kim I.S....Ko J. (2005)

External Searches for CCL16 gene

Genome Databases showing CCL16 gene

Other Databases showing CCL16 gene

Specialized Databases showing CCL16 gene

Products
for CCL16 gene