Aliases for CCL15-CCL14 Gene
Subcategory (RNA class) for CCL15-CCL14 Gene
ncRNA
Quality Score for this RNA gene is
3
External Ids for CCL15-CCL14 Gene
- HGNC: 44436
- Entrez Gene: 348249
- Ensembl: ENSG00000275688
Previous GeneCards Identifiers for CCL15-CCL14 Gene
- GC17M034316
- GC17M034348
- GC17M034392
Summaries for CCL15-CCL14 Gene
-
A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts, but they are represented as non-coding because they are candidates for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Dec 2009]
GeneCards Summary for CCL15-CCL14 Gene
CCL15-CCL14 (CCL15-CCL14 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL15-CCL14 Gene
Genomics for CCL15-CCL14 Gene
Regulatory Element Products
Genomic Location for CCL15-CCL14 Gene
- Chromosome:
- 17
- Start:
- 35,983,656 bp from pter
- End:
- 36,002,038 bp from pter
- Size:
- 18,383 bases
- Orientation:
- Minus strand
Genomic View for CCL15-CCL14 Gene
Genes around CCL15-CCL14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
CCL15-CCL14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL15-CCL14 Gene
No data available for Regulatory Elements for CCL15-CCL14 Gene
Proteins for CCL15-CCL14 Gene
-
Protein details for CCL15-CCL14 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0B4J2E2
- Recommended name:
- C-C motif chemokine
- Protein Accession:
- A0A0B4J2E2
Protein attributes for CCL15-CCL14 Gene
- Size:
- 113 amino acids
- Molecular mass:
- 12236 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CCL15-CCL14 Gene
No Post-translational modifications
Other Protein References for CCL15-CCL14 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for CCL15-CCL14
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCL15-CCL14
- Origene Custom Protein Services for CCL15-CCL14
- Search GeneTex for Proteins for CCL15-CCL14
Assay Products
No data available for DME Specific Peptides for CCL15-CCL14 Gene
Domains & Families for CCL15-CCL14 Gene
Protein Domains for CCL15-CCL14 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCL15-CCL14 Gene
Function for CCL15-CCL14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IEA | -- |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0008009 | chemokine activity | IEA | -- |
| GO:0048020 | CCR chemokine receptor binding | IBA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL15-CCL14
-
- Search ViGene Biosciences for CCL15-CCL14
CRISPR Products
- Browse CRISPR knockouts for CCL15-CCL14
miRNA Products
- Search ViGene Biosciences for CCL15-CCL14
Inhibitory RNA Products
- Search ViGene Biosciences for CCL15-CCL14
Clone Products
- GenScript: Custom all cDNA clones Services for CCL15-CCL14
- VectorBuilder custom plasmid, inducible vectors for CCL15-CCL14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL15-CCL14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for CCL15-CCL14
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL15-CCL14 Gene
Localization for CCL15-CCL14 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCL15-CCL14 Gene
Pathways & Interactions for CCL15-CCL14 Gene
No Data Available
Interacting Proteins for CCL15-CCL14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006935 | chemotaxis | IEA | -- |
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IBA | -- |
| GO:0030593 | neutrophil chemotaxis | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CCL15-CCL14 Gene
Transcripts for CCL15-CCL14 Gene
mRNA/cDNA for CCL15-CCL14 Gene
- (135) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CCL15-CCL14
miRNA Products
- Search ViGene Biosciences for CCL15-CCL14
Inhibitory RNA Products
- Search ViGene Biosciences for CCL15-CCL14
Clone Products
- GenScript: Custom all cDNA clones Services for CCL15-CCL14
- VectorBuilder custom plasmid, inducible vectors for CCL15-CCL14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL15-CCL14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for CCL15-CCL14 Gene
- GeneLoc Exon Structure for
- CCL15-CCL14
- ECgene alternative splicing isoforms for
- CCL15-CCL14
Expression for CCL15-CCL14 Gene
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL15-CCL14 Gene
Orthologs for CCL15-CCL14 Gene
Evolution for CCL15-CCL14 Gene
- ENSEMBL:
- Gene Tree for CCL15-CCL14 (if available)
- TreeFam:
- Gene Tree for CCL15-CCL14 (if available)
No data available for Orthologs for CCL15-CCL14 Gene
Paralogs for CCL15-CCL14 Gene
Variants for CCL15-CCL14 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000058564 | -- | 35,996,059(+) | CTACA(-/GGAG)GGAGG | intron-variant | |
| rs1000067753 | -- | 35,990,780(+) | CCTTC(C/T)AAGTA | intron-variant | |
| rs1000098149 | -- | 35,990,506(+) | TCACC(A/C)TGTTG | intron-variant | |
| rs1000240361 | -- | 35,987,142(+) | CATTG(A/G)TCAAG | intron-variant, upstream-variant-2KB | |
| rs1000335053 | -- | 35,984,683(+) | TCAAC(A/C)CCTCT | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640462 | CNV | gain | 21293372 |
| nsv1055760 | CNV | gain | 25217958 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv833424 | CNV | gain | 17160897 |
| nsv833427 | CNV | loss | 17160897 |
Relevant External Links for CCL15-CCL14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCL15-CCL14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CCL15-CCL14 Gene
Disorders for CCL15-CCL14 Gene
Relevant External Links for CCL15-CCL14
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCL15-CCL14
No disorders were found for CCL15-CCL14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL15-CCL14 Gene
Publications for CCL15-CCL14 Gene
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
- Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. (PMID: 11527984) Forssmann U. … Forssmann W.G. (J. Leukoc. Biol. 2001) 3 64
- Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 64
- HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A. … Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 64
Products for CCL15-CCL14 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCL15-CCL14
- Origene Custom Protein Services for CCL15-CCL14
- Browse OriGene Inhibitory RNA Products For CCL15-CCL14
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for CCL15-CCL14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL15-CCL14
- GenScript: Custom all cDNA clones Services for CCL15-CCL14
- GenScript Custom Purified and Recombinant Proteins Services for CCL15-CCL14
- GenScript Custom Assay Services for CCL15-CCL14
- GenScript Custom overexpressing Cell Line Services for CCL15-CCL14
- Browse GenScript CRISPR for CCL15-CCL14
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL15-CCL14
- Browse Sino Biological cDNA Clones
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- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL15-CCL14
- VectorBuilder custom plasmid, inducible vectors for CCL15-CCL14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL15-CCL14
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCL15-CCL14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer