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Aliases for CCL15-CCL14 Gene

Subcategory (RNA class) for CCL15-CCL14 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for CCL15-CCL14 Gene

  • CCL15-CCL14 Readthrough (NMD Candidate) 2 3 5

External Ids for CCL15-CCL14 Gene

Previous GeneCards Identifiers for CCL15-CCL14 Gene

  • GC17M034316
  • GC17M034348
  • GC17M034392

Summaries for CCL15-CCL14 Gene

Entrez Gene Summary for CCL15-CCL14 Gene

  • A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts, but they are represented as non-coding because they are candidates for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Dec 2009]

GeneCards Summary for CCL15-CCL14 Gene

CCL15-CCL14 (CCL15-CCL14 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

Additional gene information for CCL15-CCL14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL15-CCL14 Gene

Genomics for CCL15-CCL14 Gene

Genomic Location for CCL15-CCL14 Gene

Chromosome:
17
Start:
35,983,656 bp from pter
End:
36,002,038 bp from pter
Size:
18,383 bases
Orientation:
Minus strand

Genomic View for CCL15-CCL14 Gene

Genes around CCL15-CCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL15-CCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL15-CCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL15-CCL14 Gene

No data available for Regulatory Elements for CCL15-CCL14 Gene

Proteins for CCL15-CCL14 Gene

  • Protein details for CCL15-CCL14 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J2E2
    Recommended name:
    C-C motif chemokine
    Protein Accession:
    A0A0B4J2E2

    Protein attributes for CCL15-CCL14 Gene

    Size:
    113 amino acids
    Molecular mass:
    12236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL15-CCL14 Gene

Post-translational modifications for CCL15-CCL14 Gene

No Post-translational modifications

Other Protein References for CCL15-CCL14 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for CCL15-CCL14 Gene

Domains & Families for CCL15-CCL14 Gene

Protein Domains for CCL15-CCL14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCL15-CCL14: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCL15-CCL14 Gene

Function for CCL15-CCL14 Gene

Phenotypes From GWAS Catalog for CCL15-CCL14 Gene

Gene Ontology (GO) - Molecular Function for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL15-CCL14 Gene

Localization for CCL15-CCL14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL15-CCL14 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CCL15-CCL14 Gene

Pathways & Interactions for CCL15-CCL14 Gene

SuperPathways for CCL15-CCL14 Gene

No Data Available

Interacting Proteins for CCL15-CCL14 Gene

Gene Ontology (GO) - Biological Process for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0030593 neutrophil chemotaxis IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

No data available for Pathways by source and SIGNOR curated interactions for CCL15-CCL14 Gene

Drugs & Compounds for CCL15-CCL14 Gene

No Compound Related Data Available

Transcripts for CCL15-CCL14 Gene

mRNA/cDNA for CCL15-CCL14 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CCL15-CCL14 Gene

No ASD Table

Relevant External Links for CCL15-CCL14 Gene

GeneLoc Exon Structure for
CCL15-CCL14
ECgene alternative splicing isoforms for
CCL15-CCL14

Expression for CCL15-CCL14 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL15-CCL14 Gene

Orthologs for CCL15-CCL14 Gene

Evolution for CCL15-CCL14 Gene

ENSEMBL:
Gene Tree for CCL15-CCL14 (if available)
TreeFam:
Gene Tree for CCL15-CCL14 (if available)

No data available for Orthologs for CCL15-CCL14 Gene

Paralogs for CCL15-CCL14 Gene

Paralogs for CCL15-CCL14 Gene

genes like me logo Genes that share paralogs with CCL15-CCL14: view

Variants for CCL15-CCL14 Gene

Sequence variations from dbSNP and Humsavar for CCL15-CCL14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000058564 -- 35,996,059(+) CTACA(-/GGAG)GGAGG intron-variant
rs1000067753 -- 35,990,780(+) CCTTC(C/T)AAGTA intron-variant
rs1000098149 -- 35,990,506(+) TCACC(A/C)TGTTG intron-variant
rs1000240361 -- 35,987,142(+) CATTG(A/G)TCAAG intron-variant, upstream-variant-2KB
rs1000335053 -- 35,984,683(+) TCAAC(A/C)CCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL15-CCL14 Gene

Variant ID Type Subtype PubMed ID
esv3640462 CNV gain 21293372
nsv1055760 CNV gain 25217958
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Relevant External Links for CCL15-CCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL15-CCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CCL15-CCL14 Gene

Disorders for CCL15-CCL14 Gene

Relevant External Links for CCL15-CCL14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL15-CCL14

No disorders were found for CCL15-CCL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL15-CCL14 Gene

Publications for CCL15-CCL14 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  3. Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. (PMID: 11527984) Forssmann U … Forssmann WG (Journal of leukocyte biology 2001) 3 60
  4. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 60
  5. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A … Mägert HJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 60

Products for CCL15-CCL14 Gene

Sources for CCL15-CCL14 Gene

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