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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCL15 Gene

protein-coding GIFtS: 56
GCID: GC17M034315

chemokine (C-C motif) ligand 15

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA15)

Explore 24 diseases affiliated with
CCL15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Ligand 15¹ ²		MIP-1 Delta² ³
SCYA15¹ ² ³ ⁵		LKN1² ⁵
HCC-2¹ ² ³		Lkn-1¹
MIP-5¹ ² ³		MIP-1d¹
NCC-3¹ ² ³		MIP-1D²
NCC3² ³ ⁵		MRP-2B²
HMRP-2B¹ ²		SY15²
SCYL3¹ ²		C-C Motif Chemokine 15²
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15¹ ²		Leukotactin 1²
Chemokine CC-2² ³		New CC Chemokine 3²
Macrophage Inflammatory Protein 5² ³		Leukotactin-1³
Small-Inducible Cytokine A15² ³		MIP5³
LKN-1² ³		Mrp-2b³

External Ids:	HGNC: 10613¹	Entrez Gene: 6359²	Ensembl: ENSG00000161574⁷	OMIM: 601393⁵	UniProtKB: Q16663³

ORGUL members:
	NONCODE:n408069

Export aliases for CCL15 gene to outside databases

Previous GC identifers: GC17U990091 GC17M036348 GC17M034160 GC17M034458 GC17M034460 GC17M031336 GC17M034312 GC17M030509

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL15:

This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC

cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is

chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is

further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from

this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663

Function: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts

mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent

chemoattractants than the small-inducible cytokine A15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CCL15
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL15 promoter sequence

Search SABiosciences Chromatin IP Primers for CCL15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2

CCL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL15 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M034315: view genomic region (about GC identifiers)

Start:	34,310,692 bp from pter	End:	34,329,100 bp from pter
Size:	18,409 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663 (See protein sequence)

Recommended Name: C-C motif chemokine 15 precursor

Size: 113 amino acids; 12248 Da

Subunit: Monomer

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for CCL15:

2HCC (3D)

Secondary accessions: B2RU34 E1P651 Q9UM74

Explore the universe of human proteins at neXtProt for CCL15: NX_Q16663

CCL15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_116741.1

ENSEMBL proteins:

ENSP00000435993 ENSP00000432034

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL15 (CCL15/MIP-1 delta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CCL15 OriGene Protein Over-expression Lysate (see all 5): CCL15 OriGene Custom Protein Services for CCL15
	GenScript Purified and Recombinant Proteins for CCL15
	Novus Biologicals CCL15 Proteins Novus Biologicals CCL15 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL15
	Uscn Proteins for CCL15

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

CCL15 for ontologies About GeneDecksing

CCL15 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCL15
	R&D Systems Antibodies for CCL15 (CCL15/MIP-1 delta)
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	GenScript Custom Superior Antibodies Services for CCL15
	Novus Biologicals CCL15 Antibodies
	Search for Antibodies for CCL15 at Abcam
	Uscn Antibodies for CCL15
	Search ThermoFisher Antibodies for CCL15

Assay Products for CCL15:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CCL15 (CCL15/MIP-1 delta) (see all)
	GenScript Custom Assay Services for CCL15
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL15

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCL15 for domains About GeneDecksing

2 InterPro domains/families:

IPR000827 Chemokine_CC_CS

IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q16663

ProtoNet protein and cluster: Q16663

1 Blocks protein family: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663

Similarity: Belongs to the intercrine beta (chemokine CC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663

Function: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts

mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent

chemoattractants than the small-inducible cytokine A15

miRNA Products:		OriGene 3'-UTR Clone: CCL15 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL15
		SwitchGear 3'UTR luciferase reporter plasmid: CCL15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL15 OriGene shRNA RFP: CCL15 OriGene siRNA: CCL15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL15

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCL15

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL15 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL15 (NM_032965)
		Sino Biological Human cDNA Clone for CCL15
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL15
		Search LifeMap BioReagents cell lines for CCL15

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL15

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	9548457
GO:0008009	chemokine activity	IEA	--
GO:0008201	heparin binding	IEA	--
GO:0042056	chemoattractant activity	IDA	15001559

CCL15 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL15 (see all 27)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 Kegg Pathways (Kegg details for CCL15):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCL15 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCL15

4 Interacting proteins for CCL15 (Q16663³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCR1	P32246³	I2D: score=3
CCR3	P51677³	I2D: score=2
CTSG	P08311³	I2D: score=1
ELANE	P08246³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006874	cellular calcium ion homeostasis	TAS	9346309
GO:0006935	chemotaxis	TAS	9600961
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	9548457
GO:0007267	cell-cell signaling	TAS	9548457

CCL15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCL15 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCL15
6 Novoseek chemical compound relationships for CCL15 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ccl3	65.6	1	17178797 (1)
rantes	61.4	7	10213461 (3), 17178797 (1), 15950960 (1), 9639518 (1)
ccl4	31.5	1	17178797 (1)
cysteine	13.4	6	15894113 (3), 11832479 (2)
calcium	12.9	7	9548457 (1), 9624581 (1), 9346309 (1), 10202040 (1) (see all 6)
cholesterol	0	1	15135248 (1)

Search CenterWatch for drugs/clinical trials and news about CCL15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCL15 gene (3 alternative transcripts):

NM_004167.4 NM_032964.3 NM_032965.4

Unigene Cluster for CCL15:

Chemokine (C-C motif) ligand 15

Hs.272493 [show with all ESTs]

Unigene Representative Sequence: NR_027921

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495214 ENST00000481427

miRNA Products:		OriGene 3'-UTR Clone: CCL15 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL15
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCL15
		SwitchGear 3'UTR luciferase reporter plasmid: CCL15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL15 OriGene shRNA RFP: CCL15 OriGene siRNA: CCL15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL15

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL15 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL15 (NM_032965)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL15

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CCL15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL15

Additional cDNA sequence:

AF031587.1 NR_027921.2 NR_027922.2 U58914.1

7 DOTS entries:

DT.75127237 DT.92418395 DT.316727 DT.100021993 DT.121004691 DT.95176090 DT.121004700

24/135 AceView cDNA sequences (see all 135):

AF039955 H22089 NM_032963 AA345971 AA699362 CD743105 NM_004590 AW117461

BC038289 BC050647 BM677878 BI837334 AA515108 NM_005064 AW827147 AK122606

NM_145898 BX284026 BC045165 Z70293 NM_032965 F18119 AI225077 AI935058

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCL15 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:									-								-
SP2:									-						-		-
SP3:
SP4:															-		-
SP5:

ECgene alternative splicing isoforms for CCL15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCL15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CCL15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCL15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCL15

SOURCE GeneReport for Unigene cluster: Hs.272493

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663

Tissue specificity: Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver,

pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from

rheumatoid patients

SABiosciences Expression via Pathway-Focused PCR Arrays including CCL15:

Angiogenic Growth Factors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Chemokines & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CCL15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL15

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCL15 gene from 2/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCL4⁶	chemokine K203	41(a)	1 → many	19(355105-375322)
zebrafish (Danio rerio)	Actinopterygii	si:dkeyp-59a8.2⁶ si:dkeyp-59a8.3⁶ (see all 6)	si:dkeyp-59a8.3 (see all 6)	30(a) 29(a) (see all 6)	many ↔ many many ↔ many (see all 6)	20(38304232-38305101) 20(38310380-38311158)

ENSEMBL Gene Tree for CCL15 (if available)
TreeFam Gene Tree for CCL15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCL15 gene

CCL16² CCL2² CCL14² CCL24² CCL4L1² CCL11² CCL7² CCL4L2²

CCL3L1² CCL5² CCL23² CCL3L3² CCL4² CCL8² CCL13² CCL26²

CCL3² CCL18²

18/23 SIMAP similar genes for CCL15 using alignment to 2 protein entries: CCL15_HUMAN (see all proteins) (see all similar genes):

CCL23 CCL5 CCL3L1 CCL3L3 CCL14 CCL17

CCL3 CCL18 CCL16 CCL4L2 LOC728835 CCL4

CCL4L1 CCL22 CCL11 CCL7 CCL8 MCP-3

CCL15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114512707^1,2	F,	--	34324146(+)	`GCTACG/ATGTCA`	3	--	int¹ ds500¹		1		WA	118
rs192511802^1,2		--	34324172(+)	`AGGTGG/TGTGAT`	3	--	int¹ ds500¹		0	--	--	--	--
rs183841509^1,2		--	34324178(+)	`GTGATA/GAGAAG`	3	--	int¹ ds500¹		0	--	--	--	--
rs150969588^1,2	C,	--	34324199(+)	`ATGAC-/TTATTA TTATT`	3	--	int¹ ds500¹		0	--	--	--	--
rs187516351^1,2		--	34324205(+)	`TATTAC/TTATTA`	3	--	int¹ ds500¹		0	--	--	--	--
rs200908513^1,2		--	34324227(+)	`TTATT-/ATTGGC`	3	--	int¹ ds500¹		0	--	--	--	--
rs192034829^1,2		--	34324285(+)	`CTTGAA/GGACTG`	3	--	int¹ ds500¹		0	--	--	--	--
rs140583590^1,2		--	34324347(+)	`GCAAAC/TGTGGA`	3	--	int¹ ds500¹		0	--	--	--	--
rs73289048^1,2	C,F,	--	34324447(+)	`ATAATG/AGATCA`	3	--	int¹ ds500¹		3		WA	122
rs116112270^1,2	F,	--	34324545(+)	`ATTAGC/GTATTT`	3	--	int¹ ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for CCL15 (34310692 - 34329100 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCL15
1 CNV: 4031

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL15

DNA2.0 Custom Variant and Variant Library Synthesis for CCL15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCL15 for disorders           About GeneDecksing

OMIM gene information: 601393    OMIM disorders: --

20/24 diseases for CCL15 (see all 24):    About MalaCards

reactive arthritis pulmonary sarcoidosis sarcoidosis bronchiolitis

renal cell carcinoma rheumatoid arthritis osteosarcoma tonsillitis

hepatitis b arthritis atherosclerosis pertussis

hepatocellular carcinoma colon cancer osteoarthritis asthma

obesity hepatitis carcinoma cholesterol

1 disease from the University of Copenhagen DISEASES database for CCL15:

Hepatocellular carcinoma

2 Novoseek disease relationships for CCL15 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	20.6	3	12759139 (1), 11943214 (1)
atherosclerosis	17.3	5	15135248 (3), 11888507 (2)

Human Genome Epidemiology (HuGE) Navigator: CCL15 (6 documents)

Export disorders for CCL15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCL15 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with CCL15)

Utopia: connect your pdf to the dynamic
world of online information

HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PubMed id 9600961)^{1, 2, 9} Pardigol A.... Maegert H.-J. (1998)
Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10. (PubMed id 9624581)^{1, 2, 9} Wang W.... Schall T.J. (1998)
Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)^{1, 2, 9} Nomiyama H.... Yoshie O. (1999)
Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. (PubMed id 9548457)^{1, 2, 9} Youn B.-S.... Kwon B.S. (1997)
Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype. (PubMed id 10320325)^{1, 2, 9} Sticht H....Adermann K. (1999)
Proteolytic activation of alternative CCR1 ligands in inflammation. (PubMed id 15905581)^{1, 2, 9} Berahovich R.D....Schall T.J. (2005)
Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PubMed id 9558365)^{1, 2, 9} Youn B.-S.... Kwon B.S. (1998)
A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)^{1, 3, 9} Naruse K....Miura R. (1996)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. (PubMed id 9129202)^{1, 2} Wells T.N.C. and Peitsch M.C. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6359	HGNC: 10613	AceView: CCL16andCCL23	Ensembl:ENSG00000161574	euGenes: HUgn6359
ECgene: CCL15	Kegg: 6359	H-InvDB: CCL15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCL15	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCL15	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CCL15

Intellectual Property for CCL15 gene
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Patent Information for CCL15 gene:
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GeneCards and IP:
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CCL15 Gene

chemokine (C-C motif) ligand 15

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CCL15 (Gene Symbol)
Chemokine (C-C Motif) Ligand 15
SCYA15
HCC-2
MIP-5
NCC-3
NCC3
HMRP-2B
SCYL3
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15
Chemokine CC-2
Macrophage Inflammatory Protein 5
Small-Inducible Cytokine A15
LKN-1
MIP-1 Delta
LKN1
Lkn-1
MIP-1d
MIP-1D
MRP-2B
SY15
C-C Motif Chemokine 15
Leukotactin 1
New CC Chemokine 3
Leukotactin-1
MIP5
Mrp-2b

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CCL15 Gene

chemokine (C-C motif) ligand 15

Aliasesfor CCL15 gene

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