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CCL15 Gene

protein-coding   GIFtS: 54
GCID: GC17M034391

Chemokine (C-C Motif) Ligand 15

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 15)
(Previous symbol: SCYA15)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 151 2     LKN12 5
SCYA151 2 3 5     CC Chemokine 31
MIP-1 Delta1 2 3     HMRP-2B2
Chemokine CC-21 2 3     MIP-1D2
Macrophage Inflammatory Protein 51 2 3     MRP-2B2
NCC32 3 5     SCYL32
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 151 2     SY152
Leukotactin 11 2     C-C Motif Chemokine 152
Small-Inducible Cytokine A152 3     New CC Chemokine 32
HCC-22 3     Leukotactin-13
LKN-12 3     MIP53
MIP-52 3     Mrp-2b3
NCC-32 3     

External Ids:    HGNC: 106131   Entrez Gene: 63592   Ensembl: ENSG000002675967   OMIM: 6013935   UniProtKB: Q166633   

Export aliases for CCL15 gene to outside databases

Previous GC identifers: GC17U990091 GC17M036348 GC17M034160 GC17M034458 GC17M034460 GC17M031336 GC17M034312 GC17M030509 GC17M034315 GC17M034345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL15 Gene:
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC
cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is
chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is
further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur
from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). (provided by RefSeq, Jan 2013)

GeneCards Summary for CCL15 Gene:
CCL15 (chemokine (C-C motif) ligand 15) is a protein-coding gene. Diseases associated with CCL15 include pulmonary sarcoidosis, and reactive arthritis. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is CCL16.

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663
Function: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells.
Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are
more potent chemoattractants than the small-inducible cytokine A15




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCL15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCL15 promoter sequence
   Search Chromatin IP Primers for CCL15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034391:  view genomic region     (about GC identifiers)

Start:
34,323,476 bp from pter      End:
34,329,084 bp from pter
Size:
5,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663 (See protein sequence)
Recommended Name: C-C motif chemokine 15 precursor  
Size: 113 amino acids; 12248 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for CCL15:
2HCC (3D)    
Secondary accessions: B2RU34 E1P651 Q9UM74

Explore the universe of human proteins at neXtProt for CCL15: NX_Q16663

Explore proteomics data for CCL15 at MOPED


See CCL15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_116741.2  
ENSEMBL proteins: 
 ENSP00000378014   ENSP00000293276  

CCL15 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CCL15 (CCL15/MIP-1 delta)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for CCL15
OriGene Protein Over-expression Lysate for CCL15
OriGene MassSpec for CCL15
OriGene Custom Protein Services for CCL15
GenScript Purified and Recombinant Proteins for CCL15
Novus Biologicals CCL15 Proteins
Novus Biologicals CCL15 Lysates
Sino Biological Recombinant Protein for CCL15
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for CCL15
Browse Proteins at Cloud-Clone Corp.

CCL15 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCL15 (CCL15/MIP-1 delta)
OriGene Antibodies for CCL15
OriGene Custom Antibody Services for CCL15
Novus Biologicals CCL15 Antibodies
Abcam antibodies for CCL15
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for CCL15
LSBio Antibodies in human, mouse, rat for CCL15

CCL15 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCL15
R&D Systems ELISAs for CCL15 (CCL15/MIP-1 delta)         (see all)
GenScript Custom Assay Services for CCL15
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands
CCL: Chemokine ligands

2 InterPro protein domains:
 IPR000827 Chemokine_CC_CS
 IPR001811 Chemokine_IL8-like_dom

Graphical View of Domain Structure for InterPro Entry Q16663

ProtoNet protein and cluster: Q16663

1 Blocks protein domain: IPB000827 Small chemokine

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663
Similarity: Belongs to the intercrine beta (chemokine CC) family


CCL15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCL15_HUMAN, Q16663
Function: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells.
Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are
more potent chemoattractants than the small-inducible cytokine A15

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS9346309
GO:0008009chemokine activity IEA--
GO:0008201heparin binding IEA--
GO:0042056chemoattractant activity IDA15001559
     
CCL15 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL15
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL15

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL15
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL15

miRNA
Products:
    
miRTarBase miRNAs that target CCL15:
hsa-mir-335-5p (MIRT016769)

Block miRNA regulation of human, mouse, rat CCL15 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCL15
SwitchGear 3'UTR luciferase reporter plasmidCCL15 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CCL15
Predesigned siRNA for gene silencing in human, mouse, rat CCL15

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCL15

Clone
Products:
     
OriGene clones in human, mouse for CCL15 (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL15 (NM_032965)
Sino Biological Human cDNA Clone for CCL15
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL15

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCL15
Browse ESI BIO Cell Lines and PureStem Progenitors for CCL15 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL15


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CCL15_HUMAN, Q16663: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

CCL15 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCL15 About   (see all 8)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
3TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCL15
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL15 (see all 27)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
JNK Pathway



2 Kegg Pathways  (Kegg details for CCL15):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway


CCL15 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL15: 
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Chemokines & Receptors in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CCL15

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for CCL15 (Q166633 ENSP000002932764) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
InteractantInteraction Details
GeneCardExternal ID(s)
CCR1P322463, ENSP000002961404I2D: score=3 STRING: ENSP00000296140
CCR3P516773, ENSP000003500034I2D: score=2 STRING: ENSP00000350003
CTSGP083113I2D: score=1 
ELANEP082463I2D: score=1 
CCR10ENSP000003325044STRING: ENSP00000332504
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006874cellular calcium ion homeostasis TAS9346309
GO:0006935chemotaxis TAS9600961
GO:0006955immune response IEA--
GO:0007165signal transduction TAS9548457
GO:0007267cell-cell signaling TAS9548457

CCL15 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCL15

6 Novoseek inferred chemical compound relationships for CCL15 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ccl3 65.6 1 17178797 (1)
rantes 61.4 7 10213461 (3), 17178797 (1), 15950960 (1), 9639518 (1)
ccl4 31.5 1 17178797 (1)
cysteine 13.4 6 15894113 (3), 11832479 (2)
calcium 12.9 7 9548457 (1), 9624581 (1), 9346309 (1), 10202040 (1) (see all 6)
cholesterol 0 1 15135248 (1)



CCL15 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CCL15 gene (3 alternative transcripts): 
NM_004167.4  NM_032964.3  NM_032965.5  

Unigene Cluster for CCL15:

Chemokine (C-C motif) ligand 15
Hs.272493  [show with all ESTs]
Unigene Representative Sequence: NR_027921
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394506 ENST00000354059

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CCL15 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCL15
SwitchGear 3'UTR luciferase reporter plasmidCCL15 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CCL15
Predesigned siRNA for gene silencing in human, mouse, rat CCL15
Clone
Products:
     
OriGene clones in human, mouse for CCL15 (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCL15 (NM_032965)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL15
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CCL15
OriGene qSTAR qPCR primer pairs in human, mouse for CCL15
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL15
  QuantiTect SYBR Green Assays in human, mouse, rat CCL15
  QuantiFast Probe-based Assays in human, mouse, rat CCL15

Additional mRNA sequence: 

AF031587.1 NR_027921.2 NR_027922.2 U58914.1 

7 DOTS entries:

DT.75127237  DT.92418395  DT.316727  DT.100021993  DT.121004691  DT.95176090  DT.121004700 

Selected AceView cDNA sequences (see all 135):

NM_032963 NM_005064 BC045165 BX284026 AA345971 BC038289 AW117461 CD743105 
H22089 NM_145898 AF039955 AW827147 AA515108 AA699362 BC050647 BM677878 
AK122606 BI837334 NM_004590 BE220149 Z70293 BM853193 AI225077 Z49270 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCL15 expression in normal human tissues (normalized intensities)      CCL15 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CCL15 Expression
About this image


CCL15 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone marrow-derived mesenchymal stem cells (Stempeucel)
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells (Stempeucel)
CCL15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCL15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.272493

UniProtKB/Swiss-Prot: CCL15_HUMAN, Q16663
Tissue specificity: Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver,
pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids
from rheumatoid patients

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL15: 
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CCL15
OriGene qSTAR qPCR primer pairs in human, mouse for CCL15
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCL15
QuantiTect SYBR Green Assays in human, mouse, rat CCL15
QuantiFast Probe-based Assays in human, mouse, rat CCL15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCL15 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii ZGC:1937066
chemokine CCL-C25y-like (LOC100000034), mRNA
30(a)
1 → many
25(25902180-25904281) ENSDARG00000070378
        Species with no ortholog for CCL15

ENSEMBL Gene Tree for CCL15 (if available)
TreeFam Gene Tree for CCL15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCL15 gene
CCL162  CCL142  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  CCL52  
CCL232  CCL3L32  CCL15-CCL142  CCL182  CCL42  
Selected SIMAP similar genes for CCL15 using alignment to 2 protein entries:     CCL15_HUMAN (see all proteins) (see all similar genes):
CCL23    CCL5    CCL3L1    CCL3L3    CCL14    CCL17
CCL3    CCL18    CCL16    CCL4L2    LOC728835    CCL4
CCL4L1    CCL22    CCL11    CCL7    CCL8    MCP-3

CCL15 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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1 SNPs for CCL15    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs8546251,2,4
----see VAR_0116402 mis40--------

HapMap Linkage Disequilibrium report for CCL15 (34323476 - 34329084 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CCL15:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833427CNV Loss17160897
nsv833424CNV Gain17160897
nsv428340CNV Gain18775914
dgv945e1CNV Complex17122850
dgv946e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCL15
DNA2.0 Custom Variant and Variant Library Synthesis for CCL15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601393    OMIM disorders: --

Selected diseases for CCL15 (see all 22):    About MalaCards
pulmonary sarcoidosis    reactive arthritis    pertussis    tonsillitis
osteosarcoma    sarcoidosis    bronchiolitis    atherosclerosis
hypoxia    osteoarthritis    renal cell carcinoma    hepatitis b
arthritis    tuberculosis    obesity    asthma
alzheimer's disease    rheumatoid arthritis    hepatocellular carcinoma    hepatitis

1 disease from the University of Copenhagen DISEASES database for CCL15:
Hepatocellular carcinoma

CCL15 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

2 Novoseek inferred disease relationships for CCL15 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma 20.6 3 12759139 (1), 11943214 (1)
atherosclerosis 17.3 5 15135248 (3), 11888507 (2)

Genetic Association Database (GAD): CCL15
Human Genome Epidemiology (HuGE) Navigator: CCL15 (6 documents)

Export disorders for CCL15 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCL15 gene, integrated from 10 sources (see all 65):
(articles sorted by number of sources associating them with CCL15)
    Utopia: connect your pdf to the dynamic
world of online information

  1. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PubMed id 9600961)1, 2, 9 Pardigol A.... Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
  2. Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10. (PubMed id 9624581)1, 2, 9 Wang W.... Schall T.J. (J. Clin. Immunol. 1998)
  3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (J. Interferon Cytokine Res. 1999)
  4. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. (PubMed id 9548457)1, 2, 9 Youn B.-S.... Kwon B.S. (J. Immunol. 1997)
  5. Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype. (PubMed id 10320325)1, 2, 9 Sticht H....Adermann K. (Biochemistry 1999)
  6. Proteolytic activation of alternative CCR1 ligands in inflammation. (PubMed id 15905581)1, 2, 9 Berahovich R.D....Schall T.J. (J. Immunol. 2005)
  7. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PubMed id 9558365)1, 2, 9 Youn B.-S.... Kwon B.S. (Blood 1998)
  8. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)1, 3, 9 Naruse K....Miura R. (Genomics 1996)
  9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6359 HGNC: 10613 AceView: CCL16andCCL23 Ensembl:ENSG00000267596 euGenes: HUgn6359
ECgene: CCL15 Kegg: 6359 H-InvDB: CCL15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCL15 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCL15 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/CCL15

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCL15 gene:
Search GeneIP for patents involving CCL15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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