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CCL14 Gene

protein-coding   GIFtS: 51
GCID: GC17M034389

Chemokine (C-C Motif) Ligand 14

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 14)
(Previous symbol: SCYA14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 141 2     CKB12
SCYA141 2 3 5     HCC-12
NCC22 3 5     HCC-32
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 141 2     MCIF2
Chemokine CC-1/CC-32 3     SCYL22
Small-Inducible Cytokine A142 3     SY142
HCC-1(1-74)2 3     C-C Motif Chemokine 142
HCC-1/HCC-32 3     Chemokine CC-32
NCC-22 3     Hemofiltrate CC Chemokine 12
CC-12     New CC Chemokine 22
CC-32     

External Ids:    HGNC: 106121   Entrez Gene: 63582   Ensembl: ENSG000002134947   OMIM: 6013925   UniProtKB: Q166273   

Export aliases for CCL14 gene to outside databases

Previous GC identifers: GC17M034081 GC17M036346 GC17M034161 GC17M034457 GC17M034459 GC17M031335 GC17M034311 GC17M030495 GC17M034314 GC17M034343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL14 Gene:
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC
cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene
induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript
variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed
that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as
GeneID: 348249. (provided by RefSeq, Dec 2009)

GeneCards Summary for CCL14 Gene:
CCL14 (chemokine (C-C motif) ligand 14) is a protein-coding gene. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It
induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM,
and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34
myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes
eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CCL14 gene promoter:
         ER-alpha   GR   GR-beta   RelA   GR-alpha   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL14 promoter sequence
   Search Chromatin IP Primers for CCL14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034389:  view genomic region     (about GC identifiers)

Start:
34,310,327 bp from pter      End:
34,329,100 bp from pter
Size:
18,774 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627 (See protein sequence)
Recommended Name: C-C motif chemokine 14 precursor  
Size: 93 amino acids; 10678 Da
2 PDB 3D structures from and Proteopedia for CCL14:
2Q8R (3D)        2Q8T (3D)    
Secondary accessions: E1P649 E1P650 Q13954
Alternative splicing: 2 isoforms:  Q16627-1   Q16627-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCL14: NX_Q16627

Explore proteomics data for CCL14 at MOPED

Post-translational modifications: 

  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by
    proteolytic cleavage after secretion in blood1
  • HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one
    Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids1
  • Glycosylation2 at Ser26

  • See CCL14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_116738.1  NP_116739.1  

    ENSEMBL proteins: 
     ENSP00000466893   ENSP00000378017   ENSP00000409197   ENSP00000468526   ENSP00000441771  

    CCL14 Human Recombinant Protein Products:

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    Novus Biologicals CCL14 Proteins
    Novus Biologicals CCL14 Lysates
    Sino Biological Recombinant Protein for CCL14
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL14
    Cloud-Clone Corp. Proteins for CCL14

     
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    antibodies-online proteins for CCL14 (40 products) 

     
    Search antibodies-online for peptides for CCL14

    CCL14 Antibody Products:

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    antibodies-online antibodies for CCL14 (56 products) 

    CCL14 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q16627

    ProtoNet protein and cluster: Q16627

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL14_HUMAN, Q16627
    Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It
    induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM,
    and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34
    myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes
    eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CCL14           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL14

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL14:
    hsa-mir-1 (MIRT023694), hsa-mir-335-5p (MIRT017688)

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    Sino Biological Human cDNA Clone for CCL14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL14

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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL14_HUMAN, Q16627: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL14 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL14
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL14 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    2 Kegg Pathways  (Kegg details for CCL14):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including CCL14: 
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CCL14 (Q166273 ENSP000004091974) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    DDX39AO001483, ENSP000002427764I2D: score=2 STRING: ENSP00000242776
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CCR1P322463, ENSP000002961404I2D: score=2 STRING: ENSP00000296140
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS8551235
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation TAS8551235

    Find genes that share ontologies with CCL14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL14

    1 Novoseek inferred chemical compound relationship for CCL14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 68.9 6 10213461 (3), 11897579 (1), 12381680 (1)



    Find genes that share compounds with CCL14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL14 gene (3 alternative transcripts): 
    NM_032962.4  NM_032963.3  NM_004166.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480944 ENST00000394509 ENST00000435911(uc010wcq.1 uc010wcr.1 uc002hkn.2)
    ENST00000586216 ENST00000536149(uc010wcs.2 uc010wct.2 uc010wcu.2)

    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CCL14

    Selected AceView cDNA sequences (see all 135):

    AA699362 AW117461 H22089 NM_005064 NM_032963 AA345971 BX284026 NM_145898 
    AF039955 BM677878 NM_004590 AW827147 BI837334 BC050647 BC038289 CD743105 
    AA515108 AK122606 BC045165 AI225077 AF031587 BI823564 BM853193 NM_032964 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAAAAAAA
    CCL14 Expression
    About this image

    CCL14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL14 Protein Expression

    UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
    Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle,
    gut, and bone marrow, present at high concentrations (1-80 nM) in plasma

        Pathway & Disease-focused RT2 Profiler PCR Array including CCL14: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCL14 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CCL141 chemokine (C-C motif) ligand 14 79.57(n)
    69.89(a)
      480603  XM_537723.4  XP_537723.3 
    zebrafish
    (Danio rerio)
    Actinopterygii ZGC:1937066
    chemokine CCL-C25y-like (LOC100000034), mRNA
    32(a)
    1 → many
    25(25902180-25904281) ENSDARG00000070378


    ENSEMBL Gene Tree for CCL14 (if available)
    TreeFam Gene Tree for CCL14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL14 gene
    CCL152  CCL162  CCL4L12  CCL3L12  CCL4L22  CCL262  CCL32  CCL52  
    CCL232  CCL3L32  CCL15-CCL142  CCL182  CCL42  
    Selected SIMAP similar genes for CCL14 using alignment to 2 protein entries:     CCL14_HUMAN (see all proteins) (see all similar genes):
    CCL3    CCL3L1    CCL3L3    CCL18    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL24    CCL23    CCL15    CCL16
    CCL17    CCL5    CCL7    MCP-3    CCL13    CCL8

    Find genes that share paralogs with CCL14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for CCL14    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169718021,2,4
    ----see VAR_0487072 mis40--------

    HapMap Linkage Disequilibrium report for CCL14 (34310327 - 34329100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCL14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833427CNV Loss17160897
    nsv833424CNV Gain17160897
    nsv428340CNV Gain18775914
    dgv945e1CNV Complex17122850
    dgv946e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL14
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601392    OMIM disorders: --


    Find genes that share disorders with CCL14           About GenesLikeMe

    Genetic Association Database (GAD): CCL14
    Human Genome Epidemiology (HuGE) Navigator: CCL14 (6 documents)

    Export disorders for CCL14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL14 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CCL14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HCC-1, a novel chemokine from human plasma. (PubMed id 8551235)1, 2, 9 Schulz-Knappe P.... Forssmann W.-G. (J. Exp. Med. 1996)
    2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (J. Interferon Cytokine Res. 1999)
    3. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PubMed id 9600961)1, 2, 9 Pardigol A.... Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)1, 3, 9 Naruse K....Miura R. (Genomics 1996)
    5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. CCL genes in multiple sclerosis and systemic lupus erythematosus. (PubMed id 18602166)1, 4 Vyshkina T....Kalman B. (J. Neuroimmunol. 2008)
    9. Structural and functional characterization of CC chemokine CCL14. (PubMed id 17691823)1, 2 Blain K.Y.... Choe S. (Biochemistry 2007)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6358 HGNC: 10612 AceView: CCL16andCCL23 Ensembl:ENSG00000213494 euGenes: HUgn6358
    ECgene: CCL14 Kegg: 6358 H-InvDB: CCL14

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL14

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL14 gene:
    Search GeneIP for patents involving CCL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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