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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL14 Gene

protein-coding   GIFtS: 54
GCID: GC17M034314

chemokine (C-C motif) ligand 14

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA14)
 Explore 12 diseases affiliated with
CCL14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL14    

Aliases
for CCL14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 141 2     HCC-1(1-74)2 3
SCYA141 2 3 5     HCC-1/HCC-32 3
NCC-21 2 3     CKb11
NCC22 3 5     CC-12
HCC-11 2     CC-32
HCC-31 2     CKB12
MCIF1 2     SY142
SCYL21 2     C-C Motif Chemokine 142
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 141 2     Chemokine CC-32
Chemokine CC-1/CC-32 3     Hemofiltrate CC Chemokine 12
Small-Inducible Cytokine A142 3     New CC Chemokine 22

External Ids:    HGNC: 106121   Entrez Gene: 63582   Ensembl: ENSG000002134947   OMIM: 6013925   UniProtKB: Q166273   

Export aliases for CCL14 gene to outside databases

Previous GC identifers: GC17M034081 GC17M036346 GC17M034161 GC17M034457 GC17M034459 GC17M031335 GC17M034311 GC17M030495


Summaries
for CCL14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL14:
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines
are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in
intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different
isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the
upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. (provided by RefSeq,
Dec 2009)

UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced
intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was
inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid
progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and
T-cells and is a ligand for CCR1, CCR3 and CCR5




Genomic Views
for CCL14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL14 gene promoter:
         ER-alpha   GR   GR-beta   RelA   GR-alpha   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034314:  view genomic region     (about GC identifiers)

Start:
 34,310,327 bp from pter      End:
 34,329,100 bp from pter
Size:
 18,774 bases      Orientation:
 minus strand

Proteins
for CCL14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627 (See protein sequence)
Recommended Name: C-C motif chemokine 14 precursor  
Size: 93 amino acids; 10678 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CCL14:
2Q8R (3D)        2Q8T (3D)    
Secondary accessions: E1P649 E1P650 Q13954
Alternative splicing: 2 isoforms:  Q16627-1   Q16627-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCL14: NX_Q16627

Post-translational modifications:

  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic
    • cleavage after secretion in blood1
  • HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one
    • Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16627

    • CCL14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_116738.1  NP_116739.1  

    ENSEMBL proteins: 
     ENSP00000466893   ENSP00000378017   ENSP00000409197   ENSP00000468526   ENSP00000441771  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): CCL14
    OriGene Protein Over-expression Lysate (see all 2): CCL14
    OriGene Custom Protein Services for CCL14 
    GenScript Purified and Recombinant Proteins for CCL14
    Novus Biologicals CCL14 Proteins
    Novus Biologicals CCL14 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL14
    Uscn Proteins for CCL14

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--


    CCL14 for ontologies           About GeneDecksing



    CCL14 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCL14

    Protein Domains /
    Families
    for CCL14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCL14 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q16627

    ProtoNet protein and cluster: Q16627

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Function
    for CCL14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
    Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced
    intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was
    inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid
    progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and
    T-cells and is a ligand for CCR1, CCR3 and CCR5

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL14
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    SwitchGear 3'UTR luciferase reporter plasmid: CCL14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL14
    OriGene shRNA RFP: CCL14
    OriGene siRNA: CCL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCL14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL14 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CCL14 (NM_032962)
    Sino Biological Human cDNA Clone for CCL14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL14 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCL14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL14

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--


    CCL14 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CCL14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL14 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    2         Kegg Pathways  (Kegg details for CCL14):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for CCL14 (Q166273 ENSP000004091974) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCBP2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    DDX39AO001483, ENSP000002427764I2D: score=2 STRING: ENSP00000242776
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CCR1P322463, ENSP000002961404I2D: score=2 STRING: ENSP00000296140
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS8551235
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation TAS8551235


    CCL14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCL14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL14
    1 Novoseek chemical compound relationship for CCL14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 68.9 6 10213461 (3), 11897579 (1), 12381680 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL14 

    Transcripts
    for CCL14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCL14 gene (3 alternative transcripts): 
    NM_032962.4  NM_032963.3  NM_004166.4  

    Unigene Cluster for CCL14:

    Chemokine (C-C motif) ligand 14
    Hs.740501  [show with all ESTs]
    Unigene Representative Sequence: BI836019
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480944 ENST00000394509 ENST00000435911(uc010wcq.1 uc010wcr.1 uc002hkn.2)
    ENST00000586216 ENST00000536149(uc010wcs.2 uc010wct.2 uc010wcu.2)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL14
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    SwitchGear 3'UTR luciferase reporter plasmid: CCL14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL14
    OriGene shRNA RFP: CCL14
    OriGene siRNA: CCL14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL14 (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCL14 (NM_032962)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL14 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL14

    Additional cDNA sequence: 

    BC038289.1 BC045165.1 Z49270.1 

    5 DOTS entries:

    DT.316727  DT.121004691  DT.121004700  DT.102822962  DT.100021993 

    24/135 AceView cDNA sequences (see all 135):

    AW117461 AW827147 CD743105 NM_145898 NM_005064 AK122606 AF039955 AA515108 
    BI837334 NM_032963 AA345971 BM677878 NM_004590 H22089 BX284026 BC050647 
    BC045165 BC038289 AA699362 NM_032965 BM853193 AX772826 U91746 AJ709798 

    GeneLoc Exon Structure


    Expression
    for CCL14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCL14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL14

    SOURCE GeneReport for Unigene cluster: Hs.740501

    UniProtKB/Swiss-Prot: CCL14_HUMAN, Q16627
    Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut,
    and bone marrow, present at high concentrations (1-80 nM) in plasma

        SABiosciences Expression via Pathway-Focused PCR Array including CCL14: 
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL14

    Orthologs
    for CCL14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCL14 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCL46
    		 chemokine K203
    		 47(a)
    		 1 → many
    		 19(355105-375322)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1937066
    si:dkeyp-59a8.26
    (see all 6)    		 si:dkeyp-59a8.2
    (see all 6)    		 29(a)
    28(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 25(25902180-25904281)
    20(38304232-38305101)


    ENSEMBL Gene Tree for CCL14 (if available)
    TreeFam Gene Tree for CCL14 (if available) 

    Paralogs
    for CCL14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL14 gene
    CCL152  CCL162  CCL22  CCL242  CCL4L12  CCL112  CCL72  CCL4L22  
    CCL3L12  CCL52  CCL232  CCL3L32  CCL42  CCL82  CCL132  CCL262  
    CCL32  CCL182  
    18/27 SIMAP similar genes for CCL14 using alignment to 2 protein entries:     CCL14_HUMAN (see all proteins) (see all similar genes):
    CCL3    CCL3L1    CCL3L3    CCL18    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL24    CCL23    CCL15    CCL16
    CCL17    CCL5    CCL7    MCP-3    CCL13    CCL8

    CCL14 for paralogs           About GeneDecksing



    Genomic Variants
    for CCL14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in CCL14 are shown (see all 90)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1894540961,2
    		--34310224(+) TAAGCA/GAAGGG 5 -- us2k1 ds50010--------
    rs761901261,2
    		C,--34310256(+) TCATGC/AATCAT 5 -- us2k1 ds50014Minor allele frequency- A:0.09CSA WA NA EA 359
    rs1137153271,2
    		--34310293(+) GGCCTG/TGAAAA 5 -- ds5001 us2k12Minor allele frequency- T:0.33CSA 3
    rs1390027941,2
    		--34310374(+) CAAATA/GATGAT 5 -- us2k1 ds50010--------
    rs1429731751,2
    		--34310375(+) AAATGA/GTGATT 5 -- us2k1 ds50010--------
    rs1474657861,2
    		--34310406(+) TGAAGC/TTTAAA 5 -- ds5001 us2k10--------
    rs1818104451,2
    		--34310449(+) GCTTGA/GAGTAT 5 -- ds5001 us2k10--------
    rs713814881,2
    		C,F,--34310490(+) TGTTGT/CTGCTG 5 -- ds5001 us2k15Minor allele frequency- C:0.12NA EA 246
    rs783394591,2
    		--34310507(+) AGACGA/GTCTTT 5 -- us2k1 ds50010--------
    rs1420326621,2
    		--34310539(+) TTCTGC/TTTCTC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCL14 (34310327 - 34329100 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CCL14
         1 CNV: 4031

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL14
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    Disorders / Diseases
    for CCL14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCL14 for disorders           About GeneDecksing

    OMIM gene information: 601392    OMIM disorders: --

    12 diseases for CCL14:    About MalaCards
    systemic lupus erythematosus    allergic rhinitis    reactive arthritis    lupus erythematosus
    rhinitis    bronchiolitis    rheumatoid arthritis    multiple sclerosis
    arthritis    osteoarthritis    breast cancer    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: CCL14 (6 documents)

    Export disorders for CCL14 gene to outside databases

    Publications
    for CCL14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL14 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with CCL14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HCC-1, a novel chemokine from human plasma. (PubMed id 8551235)1, 2, 9 Schulz-Knappe P.... Forssmann W.-G. (1996)
    2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PubMed id 10213461)1, 2, 9 Nomiyama H.... Yoshie O. (1999)
    3. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PubMed id 9600961)1, 2, 9 Pardigol A.... Maegert H.-J. (1998)
    4. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)1, 3, 9 Naruse K....Miura R. (1996)
    5. Structural and functional characterization of CC chemokine CCL14. (PubMed id 17691823)1, 2 Blain K.Y.... Choe S. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Posttranslationally processed forms of the human chemokine HCC-1. (PubMed id 10978165)1, 2 Richter R.... Forssmann W.-G. (2000)
    8. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. (PubMed id 11085751)1, 2 Detheux M....Forssmann W.-G. (2000)
    9. CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation. (PubMed id 18367676)1, 9 Hannan N.J. and Salamonsen L.A. (2008)
    10. Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. (PubMed id 11527984)1, 9 Forssmann U....Forssmann W.G. (2001)

    External Searches for CCL14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CCL14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6358 HGNC: 10612 AceView: CCL16andCCL23 Ensembl:ENSG00000213494 euGenes: HUgn6358
    ECgene: CCL14 Kegg: 6358 H-InvDB: CCL14

    Other Databases showing CCL14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCL14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CCL14

    Intellectual Property
    for CCL14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCL14 gene:
    Search GeneIP for patents involving CCL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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