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Aliases for CCL14 Gene

Aliases for CCL14 Gene

  • Chemokine (C-C Motif) Ligand 14 2 3
  • SCYA14 3 4 6
  • NCC2 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14 2 3
  • Small-Inducible Cytokine A14 3 4
  • Chemokine CC-1/CC-3 3 4
  • HCC-1(1-74) 3 4
  • HCC-1/HCC-3 3 4
  • NCC-2 3 4
  • Hemofiltrate CC Chemokine 1 3
  • C-C Motif Chemokine 14 3
  • New CC Chemokine 2 3
  • Chemokine CC-3 3
  • HCC-1 3
  • HCC-3 3
  • SCYL2 3
  • CC-1 3
  • CC-3 3
  • CKB1 3
  • MCIF 3
  • SY14 3

External Ids for CCL14 Gene

Previous HGNC Symbols for CCL14 Gene

  • SCYA14

Previous GeneCards Identifiers for CCL14 Gene

  • GC17M034081
  • GC17M036346
  • GC17M034161
  • GC17M034457
  • GC17M034459
  • GC17M031335
  • GC17M034311
  • GC17M030495
  • GC17M034314
  • GC17M034343
  • GC17M034389

Summaries for CCL14 Gene

Entrez Gene Summary for CCL14 Gene

  • This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]

GeneCards Summary for CCL14 Gene

CCL14 (Chemokine (C-C Motif) Ligand 14) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CCL14 Gene

  • Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL14 Gene

Genomics for CCL14 Gene

Regulatory Elements for CCL14 Gene

Genomic Location for CCL14 Gene

Start:
35,983,291 bp from pter
End:
35,987,004 bp from pter
Size:
3,714 bases
Orientation:
Minus strand

Genomic View for CCL14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL14 Gene

Proteins for CCL14 Gene

  • Protein details for CCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16627-CCL14_HUMAN
    Recommended name:
    C-C motif chemokine 14
    Protein Accession:
    Q16627
    Secondary Accessions:
    • E1P649
    • E1P650
    • Q13954

    Protein attributes for CCL14 Gene

    Size:
    93 amino acids
    Molecular mass:
    10678 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL14 Gene

    Alternative splice isoforms for CCL14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL14 Gene

Proteomics data for CCL14 Gene at MOPED

Post-translational modifications for CCL14 Gene

  • HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood
  • Glycosylation at Ser26
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL14 Gene

Antibody Products

  • R&D Systems Antibodies for CCL14 (CCL14/HCC-1/HCC-3)
  • R&D Systems Antibodies for CCL14 (CCL14a/HCC-1)

No data available for DME Specific Peptides for CCL14 Gene

Domains for CCL14 Gene

Gene Families for CCL14 Gene

HGNC:
  • CCL :Chemokine ligands
  • ENDOLIG :Endogenous ligands

Protein Domains for CCL14 Gene

Suggested Antigen Peptide Sequences for CCL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16627

UniProtKB/Swiss-Prot:

CCL14_HUMAN :
  • Q16627
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL14: view

Function for CCL14 Gene

Molecular function for CCL14 Gene

UniProtKB/Swiss-Prot Function: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
genes like me logo Genes that share ontologies with CCL14: view

Animal Model Products

CRISPR Products

miRNA for CCL14 Gene

miRTarBase miRNAs that target CCL14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCL14 Gene

Localization for CCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL14 Gene COMPARTMENTS Subcellular localization image for CCL14 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL14: view

Pathways for CCL14 Gene

genes like me logo Genes that share pathways with CCL14: view

Pathways by source for CCL14 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat

Interacting Proteins for CCL14 Gene

Selected Interacting proteins: Q16627-CCL14_HUMAN for CCL14 Gene via I2D

Gene Ontology (GO) - Biological Process for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 8551235
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation TAS 8551235
GO:0060326 cell chemotaxis IEA --
genes like me logo Genes that share ontologies with CCL14: view

Compounds for CCL14 Gene

(1) Novoseek inferred chemical compound relationships for CCL14 Gene

Compound -log(P) Hits PubMed IDs
rantes 68.9 5
genes like me logo Genes that share compounds with CCL14: view

Transcripts for CCL14 Gene

mRNA/cDNA for CCL14 Gene

Unigene Clusters for CCL14 Gene

Chemokine (C-C motif) ligand 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL14 Gene

No ASD Table

Relevant External Links for CCL14 Gene

GeneLoc Exon Structure for
CCL14
ECgene alternative splicing isoforms for
CCL14

Expression for CCL14 Gene

mRNA expression in normal human tissues for CCL14 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCL14 Gene

SOURCE GeneReport for Unigene cluster for CCL14 Gene Hs.740501

mRNA Expression by UniProt/SwissProt for CCL14 Gene

Q16627-CCL14_HUMAN
Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
genes like me logo Genes that share expressions with CCL14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCL14 Gene

Orthologs for CCL14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL14 35
  • 98.92 (n)
  • 97.85 (a)
cow
(Bos Taurus)
Mammalia CCL14 35
  • 76.81 (n)
  • 66.3 (a)
dog
(Canis familiaris)
Mammalia CCL14 35
  • 79.57 (n)
  • 69.89 (a)
Species with no ortholog for CCL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL14 Gene

ENSEMBL:
Gene Tree for CCL14 (if available)
TreeFam:
Gene Tree for CCL14 (if available)

Paralogs for CCL14 Gene

genes like me logo Genes that share paralogs with CCL14: view

No data available for Paralogs for CCL14 Gene

Variants for CCL14 Gene

Sequence variations from dbSNP and Humsavar for CCL14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_048707 -

Structural Variations from Database of Genomic Variants (DGV) for CCL14 Gene

Variant ID Type Subtype PubMed ID
nsv833424 CNV Gain 17160897
nsv833427 CNV Loss 17160897
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850

Relevant External Links for CCL14 Gene

HapMap Linkage Disequilibrium report
CCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL14 Gene

Disorders for CCL14 Gene

Relevant External Links for CCL14

Genetic Association Database (GAD)
CCL14
Human Genome Epidemiology (HuGE) Navigator
CCL14
genes like me logo Genes that share disorders with CCL14: view

No data available for UniProtKB/Swiss-Prot for CCL14 Gene

Publications for CCL14 Gene

  1. HCC-1, a novel chemokine from human plasma. (PMID: 8551235) Schulz-Knappe P. … Forssmann W.-G. (J. Exp. Med. 1996) 3 4 23
  2. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PMID: 8661057) Naruse K. … Miura R. (Genomics 1996) 2 3 23
  3. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A. … Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  4. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 4 23
  5. CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation. (PMID: 18367676) Hannan N.J. … Salamonsen L.A. (Biol. Reprod. 2008) 3 23

Products for CCL14 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCL14
    • Block miRNA regulation of CCL14 using miScript Target Protectors

    Sources for CCL14 Gene

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