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Aliases for CCL14 Gene

Aliases for CCL14 Gene

  • C-C Motif Chemokine Ligand 14 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14 2 3
  • Chemokine (C-C Motif) Ligand 14 2 3
  • Small-Inducible Cytokine A14 3 4
  • Chemokine CC-1/CC-3 3 4
  • HCC-1(1-74) 3 4
  • HCC-1/HCC-3 3 4
  • SCYA14 3 4
  • NCC-2 3 4
  • NCC2 3 4
  • Hemofiltrate CC Chemokine 1 3
  • C-C Motif Chemokine 14 3
  • New CC Chemokine 2 3
  • Chemokine CC-3 3
  • HCC-1 3
  • HCC-3 3
  • SCYL2 3
  • CC-1 3
  • CC-3 3
  • CKB1 3
  • MCIF 3
  • SY14 3

External Ids for CCL14 Gene

Previous HGNC Symbols for CCL14 Gene

  • SCYA14

Previous GeneCards Identifiers for CCL14 Gene

  • GC17M034081
  • GC17M036346
  • GC17M034161
  • GC17M034457
  • GC17M034459
  • GC17M031335
  • GC17M034311
  • GC17M030495
  • GC17M034314
  • GC17M034343
  • GC17M034389
  • GC17M035984
  • GC17M035986
  • GC17M036005

Summaries for CCL14 Gene

Entrez Gene Summary for CCL14 Gene

  • This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]

GeneCards Summary for CCL14 Gene

CCL14 (C-C Motif Chemokine Ligand 14) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3.

UniProtKB/Swiss-Prot for CCL14 Gene

  • Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL14 Gene

Genomics for CCL14 Gene

Regulatory Elements for CCL14 Gene

Enhancers for CCL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F036030 0.2 ENCODE 6 -44.0 -43990 1.6 CTCF GATA3 CCL18 CCL15 CCL14 GC17M036029 LOC105371746
GH17F035875 1 Ensembl ENCODE 5.4 +110.7 110664 2.2 HDGF BCOR ELF3 ZMYM3 THRB RARA TEAD3 CTBP1 ETV6 NR2F6 TAF15 ENSG00000267744 CCL14 HEATR9 CCL5 ENSG00000270240
GH17F035971 1.3 Ensembl ENCODE 4.8 +13.5 13491 3.2 PKNOX1 ATF1 MLX ZNF133 ZFP64 ARID4B ZNF48 YY1 FOS SP5 CCL18 GAS2L2 CCL14 GC17M036032 ENSG00000273736
GH17F035533 1.7 FANTOM5 Ensembl ENCODE 4.8 +449.3 449332 9.0 HDGF PKNOX1 ATF1 WRNIP1 ZNF2 YY1 ZNF143 KLF13 JUNB REST AP2B1 SLFN12L CCL5 PEX12 SLFN5 TAF5LP1 GAS2L2 SLFN11 CCL14 RFFL
GH17F036848 1.1 FANTOM5 Ensembl ENCODE 4.8 -863.5 -863521 3.1 PKNOX1 RAD21 GLIS2 ETV6 FOS CREM EGR2 SMARCA5 ZNF280D OVOL3 DDX52 CCL14 DUSP14 GC17P036813 LOC102723471
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL14 Gene

Chromosome:
17
Start:
35,983,291 bp from pter
End:
35,987,004 bp from pter
Size:
3,714 bases
Orientation:
Minus strand

Genomic View for CCL14 Gene

Genes around CCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL14 Gene

Proteins for CCL14 Gene

  • Protein details for CCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16627-CCL14_HUMAN
    Recommended name:
    C-C motif chemokine 14
    Protein Accession:
    Q16627
    Secondary Accessions:
    • E1P649
    • E1P650
    • Q13954

    Protein attributes for CCL14 Gene

    Size:
    93 amino acids
    Molecular mass:
    10678 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL14 Gene

    Alternative splice isoforms for CCL14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL14 Gene

Post-translational modifications for CCL14 Gene

  • HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
  • Glycosylation at Ser 26
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL14 Gene

Antibody Products

  • R&D Systems Antibodies for CCL14 (CCL14a/HCC-1)
  • R&D Systems Antibodies for CCL14 (CCL14/HCC-1/HCC-3)
  • Abcam antibodies for CCL14

Assay Products

No data available for DME Specific Peptides for CCL14 Gene

Domains & Families for CCL14 Gene

Gene Families for CCL14 Gene

Protein Domains for CCL14 Gene

Suggested Antigen Peptide Sequences for CCL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16627

UniProtKB/Swiss-Prot:

CCL14_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL14: view

Function for CCL14 Gene

Molecular function for CCL14 Gene

UniProtKB/Swiss-Prot Function:
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Gene Ontology (GO) - Molecular Function for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL14: view

Phenotypes for CCL14 Gene

genes like me logo Genes that share phenotypes with CCL14: view

Animal Model Products

miRNA for CCL14 Gene

miRTarBase miRNAs that target CCL14

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL14 Gene

Localization for CCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL14 Gene COMPARTMENTS Subcellular localization image for CCL14 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,TAS --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL14: view

Pathways & Interactions for CCL14 Gene

genes like me logo Genes that share pathways with CCL14: view

Interacting Proteins for CCL14 Gene

Gene Ontology (GO) - Biological Process for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006874 cellular calcium ion homeostasis TAS 8551235
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL14: view

No data available for SIGNOR curated interactions for CCL14 Gene

Drugs & Compounds for CCL14 Gene

(1) Additional Compounds for CCL14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL14: view

Transcripts for CCL14 Gene

Unigene Clusters for CCL14 Gene

Chemokine (C-C motif) ligand 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL14 Gene

No ASD Table

Relevant External Links for CCL14 Gene

GeneLoc Exon Structure for
CCL14
ECgene alternative splicing isoforms for
CCL14

Expression for CCL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL14 Gene

Protein differential expression in normal tissues from HIPED for CCL14 Gene

This gene is overexpressed in Plasma (56.5) and Serum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL14 Gene



Protein tissue co-expression partners for CCL14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL14 Gene:

CCL14

SOURCE GeneReport for Unigene cluster for CCL14 Gene:

Hs.740501

mRNA Expression by UniProt/SwissProt for CCL14 Gene:

Q16627-CCL14_HUMAN
Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
genes like me logo Genes that share expression patterns with CCL14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCL14 Gene

Orthologs for CCL14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL14 34
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia CCL14 34
  • 79.57 (n)
cow
(Bos Taurus)
Mammalia CCL14 34
  • 76.81 (n)
Species where no ortholog for CCL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL14 Gene

ENSEMBL:
Gene Tree for CCL14 (if available)
TreeFam:
Gene Tree for CCL14 (if available)

Paralogs for CCL14 Gene

genes like me logo Genes that share paralogs with CCL14: view

Variants for CCL14 Gene

Sequence variations from dbSNP and Humsavar for CCL14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10491118 -- 35,987,850(-) GTGTG(A/C)ACATG intron-variant, upstream-variant-2KB
rs111856180 -- 35,984,587(+) AGTAG(G/T)CTTTC intron-variant, upstream-variant-2KB
rs112067627 -- 35,986,569(+) CACTC(A/C)CGTGA splice-donor-variant
rs112144652 -- 35,988,157(+) CATGG(C/T)TAGTT intron-variant, upstream-variant-2KB
rs112801225 -- 35,984,337(+) ACCTA(C/G)ACAAT upstream-variant-2KB, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL14 Gene

Variant ID Type Subtype PubMed ID
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL14 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL14 Gene

Disorders for CCL14 Gene

Relevant External Links for CCL14

Genetic Association Database (GAD)
CCL14
Human Genome Epidemiology (HuGE) Navigator
CCL14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL14

No disorders were found for CCL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL14 Gene

Publications for CCL14 Gene

  1. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. (PMID: 10213461) Nomiyama H. … Yoshie O. (J. Interferon Cytokine Res. 1999) 3 4 22 64
  2. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A. … Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64
  3. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PMID: 8661057) Naruse K. … Miura R. (Genomics 1996) 2 3 22 64
  4. HCC-1, a novel chemokine from human plasma. (PMID: 8551235) Schulz-Knappe P. … Forssmann W.-G. (J. Exp. Med. 1996) 3 4 22 64
  5. A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. (PMID: 19812544) Kotarsky K. … Agace W.W. (Mucosal Immunol 2010) 3 22 64

Products for CCL14 Gene

Sources for CCL14 Gene

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