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Aliases for CCL13 Gene

Aliases for CCL13 Gene

  • Chemokine (C-C Motif) Ligand 13 2 3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13 2 3
  • Monocyte Chemoattractant Protein 4 3 4
  • Monocyte Chemotactic Protein 4 3 4
  • Small-Inducible Cytokine A13 3 4
  • CK-Beta-10 3 4
  • SCYA13 3 4
  • MCP-4 3 4
  • NCC-1 3 4
  • NCC1 3 4
  • New CC Chemokine 1 3
  • CKb10 3
  • SCYL1 3
  • MCP4 4

External Ids for CCL13 Gene

Previous HGNC Symbols for CCL13 Gene

  • SCYA13

Previous GeneCards Identifiers for CCL13 Gene

  • GC17P032453
  • GC17P034723
  • GC17P032829
  • GC17P029707
  • GC17P032684
  • GC17P028869

Summaries for CCL13 Gene

Entrez Gene Summary for CCL13 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL13 Gene

CCL13 (Chemokine (C-C Motif) Ligand 13) is a Protein Coding gene. Diseases associated with CCL13 include asthma. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL13 Gene

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL13 Gene

Genomics for CCL13 Gene

Regulatory Elements for CCL13 Gene

Genomic Location for CCL13 Gene

Chromosome:
17
Start:
34,356,452 bp from pter
End:
34,358,610 bp from pter
Size:
2,159 bases
Orientation:
Plus strand

Genomic View for CCL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL13 Gene

Proteins for CCL13 Gene

  • Protein details for CCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99616-CCL13_HUMAN
    Recommended name:
    C-C motif chemokine 13
    Protein Accession:
    Q99616
    Secondary Accessions:
    • O95689
    • Q6ICQ6

    Protein attributes for CCL13 Gene

    Size:
    98 amino acids
    Molecular mass:
    10986 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein can bind heparin

    Three dimensional structures from OCA and Proteopedia for CCL13 Gene

neXtProt entry for CCL13 Gene

Proteomics data for CCL13 Gene at MOPED

Post-translational modifications for CCL13 Gene

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL13 Gene

Domains & Families for CCL13 Gene

Gene Families for CCL13 Gene

Protein Domains for CCL13 Gene

Suggested Antigen Peptide Sequences for CCL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q99616

UniProtKB/Swiss-Prot:

CCL13_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL13: view

Function for CCL13 Gene

Molecular function for CCL13 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens
UniProtKB/Swiss-Prot Induction:
By IL1/interleukin-1 and TNF

Gene Ontology (GO) - Molecular Function for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9195948
GO:0008009 chemokine activity IDA 10072545
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL13: view

Phenotypes for CCL13 Gene

GenomeRNAi human phenotypes for CCL13:
genes like me logo Genes that share phenotypes with CCL13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL13 Gene

Localization for CCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL13 Gene COMPARTMENTS Subcellular localization image for CCL13 gene
Compartment Confidence
extracellular 5
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005623 cell TAS 9195948
genes like me logo Genes that share ontologies with CCL13: view

Pathways & Interactions for CCL13 Gene

genes like me logo Genes that share pathways with CCL13: view

Pathways by source for CCL13 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006874 cellular calcium ion homeostasis TAS 9195948
GO:0006935 chemotaxis TAS 9195948
GO:0006954 inflammatory response IEA --
GO:0006955 immune response --
genes like me logo Genes that share ontologies with CCL13: view

No data available for SIGNOR curated interactions for CCL13 Gene

Drugs & Compounds for CCL13 Gene

(3) Drugs for CCL13 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
histamine Pharma Full agonist, Agonist 852
Calcium Nutra 0

(4) Additional Compounds for CCL13 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
RANTES
Steroid
TARC
genes like me logo Genes that share compounds with CCL13: view

Transcripts for CCL13 Gene

mRNA/cDNA for CCL13 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL13 Gene

Chemokine (C-C motif) ligand 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL13 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3
SP1:
SP2: -

Relevant External Links for CCL13 Gene

GeneLoc Exon Structure for
CCL13
ECgene alternative splicing isoforms for
CCL13

Expression for CCL13 Gene

mRNA expression in normal human tissues for CCL13 Gene

mRNA differential expression in normal tissues according to GTEx for CCL13 Gene

This gene is overexpressed in Nerve - Tibial (x10.9), Colon - Transverse (x5.7), and Lung (x4.6).

SOURCE GeneReport for Unigene cluster for CCL13 Gene Hs.414629

mRNA Expression by UniProt/SwissProt for CCL13 Gene

Q99616-CCL13_HUMAN
Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells
genes like me logo Genes that share expression patterns with CCL13: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCL13 Gene

Orthologs for CCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL13 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ccl2 35
  • 70.7 (n)
  • 56.04 (a)
chimpanzee
(Pan troglodytes)
Mammalia CCL13 35
  • 89.35 (n)
  • 85.57 (a)
CCL13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl2 35
  • 68.12 (n)
  • 52.17 (a)
dog
(Canis familiaris)
Mammalia CCL13 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
Species with no ortholog for CCL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL13 Gene

ENSEMBL:
Gene Tree for CCL13 (if available)
TreeFam:
Gene Tree for CCL13 (if available)

Paralogs for CCL13 Gene

Paralogs for CCL13 Gene

genes like me logo Genes that share paralogs with CCL13: view

Variants for CCL13 Gene

Sequence variations from dbSNP and Humsavar for CCL13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs159313 -- 34,357,370(+) ATCTA(C/T)TTCTT intron-variant
rs159314 -- 34,359,065(+) GAAGT(A/G)TGGTC downstream-variant-500B
rs1431991 -- 34,355,487(+) ACTGG(A/G)CTTAT upstream-variant-2KB
rs2072069 -- 34,357,972(+) CTCCT(A/G)GGTAA intron-variant
rs2072070 -- 34,358,987(+) CCAGA(C/T)GACCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCL13 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Variation tolerance for CCL13 Gene

Residual Variation Intolerance Score: 75.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL13 Gene

HapMap Linkage Disequilibrium report
CCL13
Human Gene Mutation Database (HGMD)
CCL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL13 Gene

Disorders for CCL13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCL13 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association
Search CCL13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL13

Genetic Association Database (GAD)
CCL13
Human Genome Epidemiology (HuGE) Navigator
CCL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL13
genes like me logo Genes that share disorders with CCL13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL13 Gene

Publications for CCL13 Gene

  1. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. (PMID: 19643942) Eagan T.M. … Bakke P.S. (Eur. Respir. J. 2010) 23 67
  2. Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation. (PMID: 20139115) Breland U.M. … Aukrust P. (Cardiovasc. Res. 2010) 23 67
  3. Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. (PMID: 19236470) Kuhle J. … Czaplinski A. (Eur. J. Neurol. 2009) 23 67
  4. Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. (PMID: 19565514) Hintzen C. … Hermanns H.M. (Arthritis Rheum. 2009) 23 67
  5. Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor. (PMID: 18282300) Wang M. … Ghannoum M.A. (BMC Microbiol. 2008) 23 67

Products for CCL13 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL13
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL13
  • Block miRNA regulation of CCL13 using miScript Target Protectors

Sources for CCL13 Gene

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