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Aliases for CCL13 Gene

Aliases for CCL13 Gene

  • Chemokine (C-C Motif) Ligand 13 2 3
  • SCYA13 3 4 6
  • NCC1 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13 2 3
  • Monocyte Chemoattractant Protein 4 3 4
  • Monocyte Chemotactic Protein 4 3 4
  • Small-Inducible Cytokine A13 3 4
  • CK-Beta-10 3 4
  • MCP-4 3 4
  • NCC-1 3 4
  • C-C Motif Chemokine 13 3
  • New CC Chemokine 1 3
  • CKb10 3
  • SCYL1 3
  • MCP4 4

External Ids for CCL13 Gene

Previous Symbols for CCL13 Gene

  • SCYA13

Summaries for CCL13 Gene

Entrez Gene Summary for CCL13 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL13 Gene

CCL13 (Chemokine (C-C Motif) Ligand 13) is a Protein Coding gene. Diseases associated with CCL13 include far eastern spotted fever and spotted fever. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL13 Gene

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL13 Gene

Genomics for CCL13 Gene

Genomic Location for CCL13 Gene

Start:
34,356,452 bp from pter
End:
34,358,610 bp from pter
Size:
2,159 bases
Orientation:
Plus strand

Genomic View for CCL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL13 Gene

Regulatory Elements for CCL13 Gene

Proteins for CCL13 Gene

  • Protein details for CCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99616-CCL13_HUMAN
    Recommended name:
    C-C motif chemokine 13
    Protein Accession:
    Q99616
    Secondary Accessions:
    • O95689
    • Q6ICQ6

    Protein attributes for CCL13 Gene

    Size:
    98 amino acids
    Molecular mass:
    10986 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein can bind heparin

    Three dimensional structures from OCA and Proteopedia for CCL13 Gene

neXtProt entry for CCL13 Gene

Proteomics data for CCL13 Gene at MOPED

Post-translational modifications for CCL13 Gene

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL13 Gene

Domains for CCL13 Gene

Gene Families for CCL13 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL13 Gene

UniProtKB/Swiss-Prot:

CCL13_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • Q99616
genes like me logo Genes that share domains with CCL13: view

Function for CCL13 Gene

Molecular function for CCL13 Gene

UniProtKB/Swiss-Prot Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens
UniProtKB/Swiss-Prot Induction: By IL1/interleukin-1 and TNF

Gene Ontology (GO) - Molecular Function for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9195948
GO:0008009 chemokine activity IDA 10072545
genes like me logo Genes that share ontologies with CCL13: view

Phenotypes for CCL13 Gene

GenomeRNAi human phenotypes for CCL13:
genes like me logo Genes that share phenotypes with CCL13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCL13 Gene

Localization for CCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL13 Gene COMPARTMENTS Subcellular localization image for CCL13 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL13: view

Pathways for CCL13 Gene

genes like me logo Genes that share pathways with CCL13: view

Pathways by source for CCL13 Gene

Gene Ontology (GO) - Biological Process for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 9195948
GO:0006935 chemotaxis TAS 9195948
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007010 cytoskeleton organization IDA 10072545
genes like me logo Genes that share ontologies with CCL13: view

Compounds for CCL13 Gene

(7) Novoseek inferred chemical compound relationships for CCL13 Gene

Compound -log(P) Hits PubMed IDs
rantes 90.5 72
tarc 76.1 5
histamine 31.9 2
calcium 26.6 12
dexamethasone 0.655 1
genes like me logo Genes that share compounds with CCL13: view

Transcripts for CCL13 Gene

mRNA/cDNA for CCL13 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL13 Gene

Chemokine (C-C motif) ligand 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL13 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3
SP1:
SP2: -

Relevant External Links for CCL13 Gene

GeneLoc Exon Structure for
CCL13
ECgene alternative splicing isoforms for
CCL13

Expression for CCL13 Gene

mRNA expression in normal human tissues for CCL13 Gene

mRNA differential expression in normal tissues according to GTEx for CCL13 Gene

This gene is overexpressed in Nerve - Tibial (10.9), Colon - Transverse (5.7), and Lung (4.6).

SOURCE GeneReport for Unigene cluster for CCL13 Gene Hs.414629

mRNA Expression by UniProt/SwissProt for CCL13 Gene

Q99616-CCL13_HUMAN
Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells
genes like me logo Genes that share expressions with CCL13: view

Orthologs for CCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL13 36
  • 89.35 (n)
  • 85.57 (a)
CCL13 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCL13 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl2 36
  • 70.7 (n)
  • 56.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 19 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ccl2 36
  • 68.12 (n)
  • 52.17 (a)
Species with no ortholog for CCL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL13 Gene

ENSEMBL:
Gene Tree for CCL13 (if available)
TreeFam:
Gene Tree for CCL13 (if available)

Paralogs for CCL13 Gene

Paralogs for CCL13 Gene

genes like me logo Genes that share paralogs with CCL13: view

Variants for CCL13 Gene

Sequence variations from dbSNP and Humsavar for CCL13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs159314 -- 34,359,065(+) GAAGT(A/G)TGGTC downstream-variant-500B
rs1431991 -- 34,355,487(+) ACTGG(A/G)CTTAT upstream-variant-2KB
rs2072069 -- 34,357,972(+) CTCCT(A/G)GGTAA intron-variant
rs2072070 -- 34,358,987(+) CCAGA(C/T)GACCA downstream-variant-500B
rs3136674 -- 34,355,597(+) CCATT(C/T)TAAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCL13 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Relevant External Links for CCL13 Gene

HapMap Linkage Disequilibrium report
CCL13
Human Gene Mutation Database (HGMD)
CCL13

Disorders for CCL13 Gene

(4) University of Copenhagen DISEASES for CCL13 Gene

(14) Novoseek inferred disease relationships for CCL13 Gene

Disease -log(P) Hits PubMed IDs
inflammation 54.5 16
asthma 48.5 17
eosinophilia 41.1 2
nasal polyps 38.4 5
allergic reaction 35.5 2

Relevant External Links for CCL13

Genetic Association Database (GAD)
CCL13
Human Genome Epidemiology (HuGE) Navigator
CCL13
genes like me logo Genes that share disorders with CCL13: view

No data available for UniProtKB/Swiss-Prot for CCL13 Gene

Publications for CCL13 Gene

  1. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PMID: 9195948) Berkhout T.A. … Macphee C. (J. Biol. Chem. 1997) 3 4 23
  2. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PMID: 9060459) Godiska R. … Gray P.W. (J. Leukoc. Biol. 1997) 3 4 23
  3. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PMID: 8642349) Uguccioni M. … Baggiolini M. (J. Exp. Med. 1996) 3 4 23
  4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PMID: 8955214) Garcia-Zepeda E.A. … Luster A.D. (J. Immunol. 1996) 3 4 23
  5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PMID: 10049733) Hein H. … Bartels J. (Biochem. Biophys. Res. Commun. 1999) 3 4 23

Products for CCL13 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCL13
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CCL13
  • Block miRNA regulation of CCL13 using miScript Target Protectors

Sources for CCL13 Gene

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