Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL13 Gene

protein-coding   GIFtS: 64
GCID: GC17P032684

chemokine (C-C motif) ligand 13

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member...)
(Previous symbol: SCYA13)
 Explore 32 diseases affiliated with
CCL13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCL13    

Aliases
for CCL13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Ligand 131 2     Monocyte Chemoattractant Protein 42 3
SCYA131 2 3 5     Monocyte Chemotactic Protein 42 3
MCP-41 2 3     Small-Inducible Cytokine A132 3
NCC-11 2 3     CK-Beta-101
NCC12 3 5     MGC171341
CKb101 2     C-C Motif Chemokine 132
SCYL11 2     New CC Chemokine 12
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 131 2     MCP43

External Ids:    HGNC: 106111   Entrez Gene: 63572   Ensembl: ENSG000001813747   OMIM: 6013915   UniProtKB: Q996163   

Export aliases for CCL13 gene to outside databases

Previous GC identifers: GC17P032453 GC17P034723 GC17P032829 GC17P029707 GC17P028869


Summaries
for CCL13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCL13:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family
of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins
characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for
monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of
leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during
artherosclerosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and
non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease
process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous
pathogens




Genomic Views
for CCL13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL13 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   Meis-1b   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032684:  view genomic region     (about GC identifiers)

Start:
 32,683,471 bp from pter      End:
 32,685,629 bp from pter
Size:
 2,159 bases      Orientation:
 plus strand

Proteins
for CCL13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616 (See protein sequence)
Recommended Name: C-C motif chemokine 13 precursor  
Size: 98 amino acids; 10986 Da
Subcellular location: Secreted
Mass spectrometry: Mass=9314; Mass_error=30; Method=MALDI; Range=17-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8760; Mass_error=30; Method=MALDI; Range=22-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8575; Mass_error=30; Method=MALDI; Range=24-98; Source=PubMed:8642349;
Miscellaneous: This protein can bind heparin
1 PDB 3D structure from and Proteopedia for CCL13:
2RA4 (3D)    
Secondary accessions: O95689 Q6ICQ6

Explore the universe of human proteins at neXtProt for CCL13: NX_Q99616

Post-translational modifications:

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal
    • peptide cleavage. The medium chain is about 30-fold less active than the long chain1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99616

    • CCL13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005399.1  
    ENSEMBL proteins: 
     ENSP00000225844   ENSP00000463667  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL13 (CCL13/MCP-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CCL13
    OriGene Custom Protein Services for CCL13 
    GenScript Purified and Recombinant Proteins for CCL13
    Novus Biologicals CCL13 Proteins
    Novus Biologicals CCL13 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CCL13
    Uscn Proteins for CCL13

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--


    CCL13 for ontologies           About GeneDecksing



    CCL13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL13 (CCL13/MCP-4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCL13 
    GenScript Superior Antibodies for CCL13
    Novus Biologicals CCL13 Antibodies
    Search for Antibodies for CCL13 at Abcam  
    Uscn Antibodies for CCL13
    ThermoFisher Antibodies for CCL13

    Assay Products for CCL13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for CCL13 (CCL13/MCP-4)
    GenScript Custom Assay Services for CCL13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCL13

    Protein Domains /
    Families
    for CCL13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCL13 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99616

    ProtoNet protein and cluster: Q99616

    1 Blocks protein family: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Function
    for CCL13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
    Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and
    non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease
    process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous
    pathogens
    Induction: By IL1/interleukin-1 and TNF

    miRNA
    Products:            		miRTarBase miRNAs that target CCL13:
    hsa-let-7b (MIRT001596)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmid: CCL13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL13
    OriGene shRNA RFP: CCL13
    OriGene siRNA: CCL13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCL13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    Sino Biological Human cDNA Clone for CCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCL13
    Search LifeMap BioReagents cell lines for CCL13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9558100
    GO:0008009chemokine activity IDA10072545


    CCL13 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCL13:
     Increased cell number in G2M,  


    Pathways & Interactions
    for CCL13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5Immune response _CCR3 signaling in eosinophils
    		Immune response _CCR3 signaling in eosinophils1.00
    		Immune response CCR3 signaling in eosinophils1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCL13
        Immune response CCR3 signaling in eosinophils

    17/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL13 (see all 28) (see first 5)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway
    Tec Kinases Signaling
    Transendothelial Migration of Leukocytes
    MAPK Family Pathway
    Renin-Angiotensin Pathway
    MIF Mediated Glucocorticoid Regulation
    Rho Family GTPases
    Akt Signaling
    PAK Pathway
    Chemokine Signaling
    MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    JAK-STAT Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL13
        Immune response CCR3 signaling in eosinophils


    2         Kegg Pathways  (Kegg details for CCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCL13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for CCL13 (Q996162, 3 ENSP000002258444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH3P319422, 3MINT-63662 I2D: score=4 
    CCBP2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    CCR5P516813, ENSP000002923034I2D: score=2 STRING: ENSP00000292303
    CCRL1Q9NPB93, ENSP000002498874I2D: score=2 STRING: ENSP00000249887
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS9195948
    GO:0006935chemotaxis TAS9195948
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007010cytoskeleton organization IDA10072545


    CCL13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCL13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL13
    7 Novoseek chemical compound relationships for CCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.5 86 10570327 (4), 10725746 (4), 9276730 (4), 10553092 (3) (see all 49)
    tarc 76.1 6 10419874 (1), 19236470 (1), 9430724 (1), 15644118 (1) (see all 5)
    histamine 31.9 2 8955214 (1), 9276730 (1)
    calcium 26.6 17 10069890 (2), 8955214 (1), 9365122 (1), 10072545 (1) (see all 11)
    dexamethasone 0.655 1 11597922 (1)
    oxygen 0 3 9367876 (1), 9551887 (1), 11286614 (1)
    steroid 0 3 15523430 (2)

    Search CenterWatch for drugs/clinical trials and news about CCL13 

    Transcripts
    for CCL13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCL13 gene: 
    NM_005408.2  

    Unigene Cluster for CCL13:

    Chemokine (C-C motif) ligand 13
    Hs.414629  [show with all ESTs]
    Unigene Representative Sequence: NM_005408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225844(uc002hic.3) ENST00000577681

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmid: CCL13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL13
    OriGene shRNA RFP: CCL13
    OriGene siRNA: CCL13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13

    Additional cDNA sequence: 

    AJ001634.1 BC008621.1 BT007385.1 CR450337.1 U46767.1 U59808.1 X98306.1 Z77650.1 
    Z77651.1 

    1 DOTS entry:

    DT.110724 

    24/28 AceView cDNA sequences (see all 28):

    BC008621 CR450337 CK902425 U59808 BX119227 AA403048 BU071409 NM_005408 
    Z77651 AJ001634 BM991948 AW204819 BG620880 AI459919 U46767 AW015321 
    AA760939 AA404346 AA426245 BF339001 Z77650 BT007385 BU071645 AI925360 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL13    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for CCL13

    Expression
    for CCL13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGGATGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL13

    SOURCE GeneReport for Unigene cluster: Hs.414629

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node.
    Low levels seen in the pulmonary artery smooth muscle cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

    Orthologs
    for CCL13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCL13 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkeyp-59a8.36
    si:dkeyp-59a8.16
    (see all 6)    		 si:dkeyp-59a8.1
    (see all 6)    		 32(a)
    31(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 20(38310380-38311158)
    20(38282475-38302293)


    ENSEMBL Gene Tree for CCL13 (if available)
    TreeFam Gene Tree for CCL13 (if available) 

    Paralogs
    for CCL13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL13 gene
    CCL152  CCL162  CCL22  CCL142  CCL242  CCL4L12  CCL112  CCL72  
    CCL4L22  CCL3L12  CCL52  CCL232  CCL3L32  CCL42  CCL82  CCL262  
    CCL32  CCL182  
    18/28 SIMAP similar genes for CCL13 using alignment to 3 protein entries:     CCL13_HUMAN (see all proteins) (see all similar genes):
    CCL2    CCL11    CCL7    MCP-3    CCL8    XCL1
    XCL2    CCL3L1    CCL3L3    CCL3    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL18    CCL14    CCL5    CCL1

    CCL13 for paralogs           About GeneDecksing



    Genomic Variants
    for CCL13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 NCBI SNPs in CCL13 are shown (see all 96)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1178604541,2
    		--32681505(+) GGAGAC/TAACAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143110701,2
    		F,--32681562(+) AGAAGC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1494938441,2
    		--32681582(+) ACCCAA/GTCAGA 1 -- us2k10--------
    rs1148537051,2
    		--32681621(+) TAACCC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1885869581,2
    		--32681693(+) AGCTTA/GTAATA 1 -- us2k10--------
    rs1929586551,2
    		--32681782(+) CTTTTG/TATATT 1 -- us2k10--------
    rs728270141,2
    		C,F,--32681871(+) CCCAGA/GGAATG 1 -- us2k13Minor allele frequency- G:0.07WA NA EA 358
    rs1459717661,2
    		--32681888(+) GGGAAG/TATTTT 1 -- us2k10--------
    rs1398399891,2
    		--32681890(+) GAAGAC/TTTTCA 1 -- us2k10--------
    rs1848696971,2
    		--32681915(+) TTCTTC/TAATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL13 (32683471 - 32685629 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CCL13
         1 CNV: 49841
    Human Gene Mutation Database (HGMD): CCL13

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL13
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL13

    Disorders / Diseases
    for CCL13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCL13 for disorders           About GeneDecksing

    OMIM gene information: 601391    OMIM disorders: --

    20/32 diseases for CCL13 (see all 32):    About MalaCards
    far eastern spotted fever    human immunodeficiency virus infectious disease    allergic rhinitis    bullous pemphigoid
    amyotrophic lateral sclerosis    lateral sclerosis    atopic dermatitis    rhinitis
    eosinophilia    dermatitis    bronchiolitis    nephrotic syndrome
    rheumatoid arthritis    asthma    multiple sclerosis    atopy
    tonsillitis    gastric adenocarcinoma    hepatitis b    encephalomyelitis

    4 diseases from the University of Copenhagen DISEASES database for CCL13:
    Asthma     Atopic dermatitis     Eosinophilia     Far Eastern spotted fever

    10/14 Novoseek disease relationships for CCL13 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 54.5 21 11400154 (2), 8955214 (1), 10808183 (1), 11391951 (1) (see all 15)
    asthma 48.5 34 15046375 (8), 10934112 (4), 10069883 (3), 12805085 (1) (see all 5)
    eosinophilia 41.1 2 10415058 (1), 10491000 (1)
    nasal polyps 38.4 6 15523430 (2), 17851891 (2), 10415058 (1)
    allergic reaction 35.5 2 10934112 (1), 10491000 (1)
    necrosis 30.8 8 10934112 (1), 9060459 (1), 20139115 (1), 19643942 (1) (see all 7)
    allergy 29.5 3 9800627 (1), 10875484 (1), 10640766 (1)
    allergic rhinitis 23.5 2 10359883 (1), 17982926 (1)
    asthma allergic 18.4 2 10934112 (1)
    dermatitis atopic 4.84 1 10808183 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCL13 (13 documents)

    Export disorders for CCL13 gene to outside databases

    Publications
    for CCL13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL13 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with CCL13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PubMed id 8642349)1, 2, 9 Uguccioni M.... Baggiolini M. (1996)
    2. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PubMed id 9195948)1, 2, 9 Berkhout T.A.... Macphee C. (1997)
    3. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PubMed id 9060459)1, 2, 9 Godiska R....Gray P.W. (1997)
    4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PubMed id 8955214)1, 2, 9 Garcia-Zepeda E.A.... Luster A.D. (1996)
    5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PubMed id 10049733)1, 2, 9 Hein H....Bartels J. (1999)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)1, 3 Naruse K....Miura R. (1996)
    9. Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. (PubMed id 12805085)1, 9 Kalayci O....Lilly C.M. (2003)
    10. Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. (PubMed id 19565514)1, 9 Hintzen C....Hermanns H.M. (2009)

    External Searches for CCL13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCL13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6357 HGNC: 10611 AceView: CCL13 Ensembl:ENSG00000181374 euGenes: HUgn6357
    ECgene: CCL13 Kegg: 6357 H-InvDB: CCL13

    Other Databases showing CCL13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCL13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL13 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL13

    Intellectual Property
    for CCL13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCL13 gene:
    Search GeneIP for patents involving CCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCL13 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCL13 (CCL13/MCP-4)   Browse Cell Culture Products  
     ELISAs for CCL13 (CCL13/MCP-4)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CCL13 (CCL13/MCP-4)  
     Browse OriGene Antibodies   OriGene shRNA RFP for CCL13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL13  
     OriGene Protein Over-expression Lysate for CCL13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CCL13   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCL13   OriGene Custom Protein Services for CCL13  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCL13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL13
     GenScript Purified and Recombinant Proteins for CCL13 GenScript cDNA clones with any tag delivered in your preferred vector for CCL13
     GenScript Custom Assay Services for CCL13 GenScript Superior Antibodies for CCL13
     GenScript Custom overexpressing Cell Line Services for CCL13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCL13 promoter
     Search Chromatin IP Primers for CCL13
     RT2 qPCR Primer Assay in human, mouse, rat CCL13
     GNC Network for CCL13
     SABiosciences PCR Arrays including human, mouse, rat CCL13
     Search Tocris compounds for CCL13
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for CCL13
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCL13 antibodies
     CCL13 proteins
     CCL13 lysates
     Search for Antibodies for CCL13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CCL13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CCL13




     CCL13 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CCL13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13
     SwitchGear 3'UTR luciferase reporter plasmids for CCL13
     SwitchGear Promoter luciferase reporter plasmids for CCL13
     ThermoFisher Antibodies for CCL13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CCL13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4