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CCL13 Gene

protein-coding   GIFtS: 62
GCID: GC17P032684

Chemokine (C-C Motif) Ligand 13

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 13)
(Previous symbol: SCYA13)
  See CCL13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 131 2     MCP-42 3
SCYA131 2 3 5     NCC-12 3
NCC12 3 5     CKb102
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 131 2     SCYL12
Monocyte Chemoattractant Protein 42 3     C-C Motif Chemokine 132
Monocyte Chemotactic Protein 42 3     New CC Chemokine 12
Small-Inducible Cytokine A132 3     MCP43
CK-beta-102 3     

External Ids:    HGNC: 106111   Entrez Gene: 63572   Ensembl: ENSG000001813747   OMIM: 6013915   UniProtKB: Q996163   

Export aliases for CCL13 gene to outside databases

Previous GC identifers: GC17P032453 GC17P034723 GC17P032829 GC17P029707 GC17P028869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL13 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in
accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the
arterial wall during artherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL13 Gene:
CCL13 (chemokine (C-C motif) ligand 13) is a protein-coding gene. Diseases associated with CCL13 include far eastern spotted fever, and spotted fever. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
exposed to exogenous pathogens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL13 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   Meis-1b   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL13 promoter sequence
   Search Chromatin IP Primers for CCL13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032684:  view genomic region     (about GC identifiers)

Start:
32,683,471 bp from pter      End:
32,685,629 bp from pter
Size:
2,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616 (See protein sequence)
Recommended Name: C-C motif chemokine 13 precursor  
Size: 98 amino acids; 10986 Da
Mass spectrometry: Mass=9314; Mass_error=30; Method=MALDI; Range=17-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8760; Mass_error=30; Method=MALDI; Range=22-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8575; Mass_error=30; Method=MALDI; Range=24-98; Source=PubMed:8642349;
Miscellaneous: This protein can bind heparin
1 PDB 3D structure from and Proteopedia for CCL13:
2RA4 (3D)    
Secondary accessions: O95689 Q6ICQ6

Explore the universe of human proteins at neXtProt for CCL13: NX_Q99616

Explore proteomics data for CCL13 at MOPED

Post-translational modifications: 

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal
    peptide cleavage. The medium chain is about 30-fold less active than the long chain1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCL13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005399.1  
    ENSEMBL proteins: 
     ENSP00000225844   ENSP00000463667  

    CCL13 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCL13
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL13
    GenScript Purified and Recombinant Proteins for CCL13
    Novus Biologicals CCL13 Proteins
    Novus Biologicals CCL13 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL13
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL13 

     
    antibodies-online proteins for CCL13 (37 products) 

     
    antibodies-online peptides for CCL13

    CCL13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CCL13 Antibodies
    Abcam antibodies for CCL13
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL13
    antibodies-online antibodies for CCL13 (66 products) 

    CCL13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL13 (CCL13/MCP-4)         (see all)
    GenScript Custom Assay Services for CCL13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL13 
    antibodies-online kits for CCL13 (28 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99616

    ProtoNet protein and cluster: Q99616

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL13_HUMAN, Q99616
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
    Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
    allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
    during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
    exposed to exogenous pathogens
    Induction: By IL1/interleukin-1 and TNF

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9195948
    GO:0008009chemokine activity IDA10072545
         
    Find genes that share ontologies with CCL13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL13:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCL13

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CCL13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL13
    Predesigned siRNA for gene silencing in human, mouse, rat CCL13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL13

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    Sino Biological Human cDNA Clone for CCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL13
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL13_HUMAN, Q99616: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL13 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL13
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL13 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL13
        Immune response CCR3 signaling in eosinophils



    3 Kegg Pathways  (Kegg details for CCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CCL13 (Q996162, 3 ENSP000002258444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH3P319422, 3MINT-63662 I2D: score=4 
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    ACKR4Q9NPB93, ENSP000002498874I2D: score=2 STRING: ENSP00000249887
    CCR5P516813, ENSP000002923034I2D: score=2 STRING: ENSP00000292303
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS9195948
    GO:0006935chemotaxis TAS9195948
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007010cytoskeleton organization IDA10072545

    Find genes that share ontologies with CCL13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL13

    7 Novoseek inferred chemical compound relationships for CCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.5 86 10570327 (4), 10725746 (4), 9276730 (4), 10553092 (3) (see all 49)
    tarc 76.1 6 10419874 (1), 19236470 (1), 9430724 (1), 15644118 (1) (see all 5)
    histamine 31.9 2 8955214 (1), 9276730 (1)
    calcium 26.6 17 10069890 (2), 8955214 (1), 9365122 (1), 10072545 (1) (see all 11)
    dexamethasone 0.655 1 11597922 (1)
    oxygen 0 3 9367876 (1), 9551887 (1), 11286614 (1)
    steroid 0 3 15523430 (2)



    Find genes that share compounds with CCL13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL13 gene: 
    NM_005408.2  

    Unigene Cluster for CCL13:

    Chemokine (C-C motif) ligand 13
    Hs.414629  [show with all ESTs]
    Unigene Representative Sequence: NM_005408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225844(uc002hic.3) ENST00000577681
    miRNA
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    Block miRNA regulation of human, mouse, rat CCL13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CCL13
      QuantiFast Probe-based Assays in human, mouse, rat CCL13

    Additional mRNA sequence: 

    AJ001634.1 BC008621.1 BT007385.1 CR450337.1 U46767.1 U59808.1 X98306.1 Z77650.1 
    Z77651.1 

    1 DOTS entry:

    DT.110724 

    Selected AceView cDNA sequences (see all 28):

    AA403048 CK902425 CR450337 U59808 BU071409 BX119227 NM_005408 BC008621 
    AJ001634 AW015321 AA760939 BF339001 Z77650 BG620880 Z77651 U46767 
    AA426245 BM991948 AW204819 BT007385 AA404346 AI459919 BU071645 T64262 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL13    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for CCL13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGATGCT
    CCL13 Expression
    About this image

    CCL13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414629

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph
    node. Low levels seen in the pulmonary artery smooth muscle cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL13
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    QuantiTect SYBR Green Assays in human, mouse, rat CCL13
    QuantiFast Probe-based Assays in human, mouse, rat CCL13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL13 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl21 chemokine (C-C motif) ligand 2 70.7(n)
    56.04(a)
      20296  NM_011333.3  NP_035463.1 


    ENSEMBL Gene Tree for CCL13 (if available)
    TreeFam Gene Tree for CCL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCL13 gene
    CCL112  CCL72  CCL82  CCL22  CCL242  
    Selected SIMAP similar genes for CCL13 using alignment to 3 protein entries:     CCL13_HUMAN (see all proteins) (see all similar genes):
    CCL2    CCL11    CCL7    MCP-3    CCL8    XCL1
    XCL2    CCL3L1    CCL3L3    CCL3    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL18    CCL14    CCL5    CCL1

    Find genes that share paralogs with CCL13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL13 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178604541,2
    F--32681505(+) GGAGAC/TAACAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143110701,2
    F--32681562(+) AGAAGC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1494938441,2
    --32681582(+) ACCCAA/GTCAGA 1 -- us2k10--------
    rs1148537051,2
    F--32681621(+) TAACCC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1885869581,2
    --32681693(+) AGCTTA/GTAATA 1 -- us2k10--------
    rs1929586551,2
    --32681782(+) CTTTTG/TATATT 1 -- us2k10--------
    rs728270141,2
    C,F--32681871(+) CCCAGA/GGAATG 1 -- us2k13Minor allele frequency- G:0.07WA NA EA 358
    rs1459717661,2
    --32681888(+) GGGAAG/TATTTT 1 -- us2k10--------
    rs1398399891,2
    --32681890(+) GAAGAC/TTTTCA 1 -- us2k10--------
    rs1848696971,2
    C--32681915(+) TTCTTC/TAATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL13 (32683471 - 32685629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CCL13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL13
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601391    OMIM disorders: --

    4 diseases for CCL13 (see first 20):    
    About MalaCards
    far eastern spotted fever    spotted fever    bullous pemphigoid    allergic rhinitis

    4 diseases from the University of Copenhagen DISEASES database for CCL13:
    Asthma     Atopic dermatitis     Eosinophilia     Far Eastern spotted fever

    Find genes that share disorders with CCL13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL13 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 54.5 21 11400154 (2), 8955214 (1), 10808183 (1), 11391951 (1) (see all 15)
    asthma 48.5 34 15046375 (8), 10934112 (4), 10069883 (3), 12805085 (1) (see all 5)
    eosinophilia 41.1 2 10415058 (1), 10491000 (1)
    nasal polyps 38.4 6 15523430 (2), 17851891 (2), 10415058 (1)
    allergic reaction 35.5 2 10934112 (1), 10491000 (1)
    necrosis 30.8 8 10934112 (1), 9060459 (1), 20139115 (1), 19643942 (1) (see all 7)
    allergy 29.5 3 9800627 (1), 10875484 (1), 10640766 (1)
    allergic rhinitis 23.5 2 10359883 (1), 17982926 (1)
    asthma allergic 18.4 2 10934112 (1)
    dermatitis atopic 4.84 1 10808183 (1)

    Genetic Association Database (GAD): CCL13
    Human Genome Epidemiology (HuGE) Navigator: CCL13 (13 documents)

    Export disorders for CCL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL13 gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with CCL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PubMed id 8642349)1, 2, 9 Uguccioni M.... Baggiolini M. (J. Exp. Med. 1996)
    2. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PubMed id 9195948)1, 2, 9 Berkhout T.A.... Macphee C. (J. Biol. Chem. 1997)
    3. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PubMed id 9060459)1, 2, 9 Godiska R....Gray P.W. (J. Leukoc. Biol. 1997)
    4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PubMed id 8955214)1, 2, 9 Garcia-Zepeda E.A.... Luster A.D. (J. Immunol. 1996)
    5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PubMed id 10049733)1, 2, 9 Hein H....Bartels J. (Biochem. Biophys. Res. Commun. 1999)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (Genes Immun. 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6357 HGNC: 10611 AceView: CCL13 Ensembl:ENSG00000181374 euGenes: HUgn6357
    ECgene: CCL13 Kegg: 6357 H-InvDB: CCL13

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCL13 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCL13 gene:
    Search GeneIP for patents involving CCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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